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Fusion Protein:GPRC5B-C16orf96

Fusion Gene and Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: GPRC5B-C16orf96
	FusionPDB ID: 34497
	FusionGDB2.0 ID: 34497
		Hgene	Tgene
	Gene symbol	GPRC5B	C16orf96
	Gene ID	51704	342346
	Gene name	G protein-coupled receptor class C group 5 member B	chromosome 16 open reading frame 96
	Synonyms	RAIG-2\|RAIG2	-
	Cytomap	16p12.3	16p13.3
	Type of gene	protein-coding	protein-coding
	Description	G-protein coupled receptor family C group 5 member BG protein-coupled receptor, family C, group 1, member Bretinoic acid responsive gene proteinretinoic acid-induced gene 2 protein	uncharacterized protein C16orf96
	Modification date	20200322	20200313
	UniProtAcc	Q9NZH0 Main function of 5'-partner protein: FUNCTION: Unknown. This retinoic acid-inducible G-protein coupled receptor provide evidence for a possible interaction between retinoid and G-protein signaling pathways.	A6NNT2 Main function of 5'-partner protein:
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000569479, ENST00000569847, ENST00000300571, ENST00000535671, ENST00000537135, ENST00000569102,	ENST00000444310,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	3 X 4 X 3=36	4 X 8 X 6=192
	# samples	4	10
	** MAII score	log2(4/36*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0	log2(10/192*10)=-0.941106310946431 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Fusion gene context	PubMed: GPRC5B [Title/Abstract] AND C16orf96 [Title/Abstract] AND fusion [Title/Abstract]
Fusion neoantigen context	PubMed: GPRC5B [Title/Abstract] AND C16orf96 [Title/Abstract] AND neoantigen [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	GPRC5B(19873159)-C16orf96(4621562), # samples:3
Anticipated loss of major functional domain due to fusion event.	GPRC5B-C16orf96 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. GPRC5B-C16orf96 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. GPRC5B-C16orf96 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. GPRC5B-C16orf96 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr16:19873159/chr16:4621562)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Retention analysis results of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features, are available here.

Fusion gene breakpoints across GPRC5B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across C16orf96 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Amino Acid Sequences

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000300571	GPRC5B	chr16	19873159	-	ENST00000444310	C16orf96	chr16	4621562	+	4762	1359	12	4364	1450
ENST00000535671	GPRC5B	chr16	19873159	-	ENST00000444310	C16orf96	chr16	4621562	+	4570	1167	0	4172	1390
ENST00000537135	GPRC5B	chr16	19873159	-	ENST00000444310	C16orf96	chr16	4621562	+	4879	1476	93	4481	1462
ENST00000300571	GPRC5B	chr16	19873158	-	ENST00000444310	C16orf96	chr16	4621561	+	4762	1359	12	4364	1450
ENST00000535671	GPRC5B	chr16	19873158	-	ENST00000444310	C16orf96	chr16	4621561	+	4570	1167	0	4172	1390
ENST00000537135	GPRC5B	chr16	19873158	-	ENST00000444310	C16orf96	chr16	4621561	+	4879	1476	93	4481	1462

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000300571	ENST00000444310	GPRC5B	chr16	19873159	-	C16orf96	chr16	4621562	+	0.00392389	0.99607605
ENST00000535671	ENST00000444310	GPRC5B	chr16	19873159	-	C16orf96	chr16	4621562	+	0.003060669	0.9969393
ENST00000537135	ENST00000444310	GPRC5B	chr16	19873159	-	C16orf96	chr16	4621562	+	0.002887655	0.9971123
ENST00000300571	ENST00000444310	GPRC5B	chr16	19873158	-	C16orf96	chr16	4621561	+	0.00392389	0.99607605
ENST00000535671	ENST00000444310	GPRC5B	chr16	19873158	-	C16orf96	chr16	4621561	+	0.003060669	0.9969393
ENST00000537135	ENST00000444310	GPRC5B	chr16	19873158	-	C16orf96	chr16	4621561	+	0.002887655	0.9971123

Predicted full-length fusion amino acid sequences. For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among all the predicted ones.

Get the fusion protein sequences from here.

Fusion protein sequence information is available in the fasta format.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

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Fusion Protein Breakpoint Sequences for GPRC5B-C16orf96

+/-13 AA sequence from the breakpoints of the fusion protein sequences.

Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	Length(fusion protein)	BP in fusion protein	Peptide
GPRC5B	chr16	19873158	C16orf96	chr16	4621561	1167	389	QPTEMAVVLNGGTSMQTLQDLLTDLH
GPRC5B	chr16	19873158	C16orf96	chr16	4621561	1359	449	QPTEMAVVLNGGTSMQTLQDLLTDLH
GPRC5B	chr16	19873158	C16orf96	chr16	4621561	1476	461	QPTEMAVVLNGGTSMQTLQDLLTDLH
GPRC5B	chr16	19873159	C16orf96	chr16	4621562	1167	389	QPTEMAVVLNGGTSMQTLQDLLTDLH
GPRC5B	chr16	19873159	C16orf96	chr16	4621562	1359	449	QPTEMAVVLNGGTSMQTLQDLLTDLH
GPRC5B	chr16	19873159	C16orf96	chr16	4621562	1476	461	QPTEMAVVLNGGTSMQTLQDLLTDLH

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Potential FusionNeoAntigen Information of GPRC5B-C16orf96 in HLA I

Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.

GPRC5B-C16orf96_19873158_4621561.msa

Potential FusionNeoAntigen Information
* We used NetMHCpan v4.1 (%rank<0.5) and deepHLApan v1.1 (immunogenic score>0.5)

Fusion gene	Hchr	Hbp	Tgene	Tchr	Tbp	HLA I	FusionNeoAntigen peptide	Binding score	Immunogenic score	Neoantigen start (at BP 13)	Neoantigen end (at BP 13)
GPRC5B-C16orf96	chr16	19873158	chr16	4621561	1359	HLA-B15:25	VVLNGGTSM	0.9686	0.9615	6	15
GPRC5B-C16orf96	chr16	19873158	chr16	4621561	1359	HLA-B15:02	VVLNGGTSM	0.9629	0.9668	6	15
GPRC5B-C16orf96	chr16	19873158	chr16	4621561	1359	HLA-B46:01	VVLNGGTSM	0.8373	0.5392	6	15
GPRC5B-C16orf96	chr16	19873158	chr16	4621561	1359	HLA-C03:19	TSMQTLQDL	0.9987	0.9852	12	21
GPRC5B-C16orf96	chr16	19873158	chr16	4621561	1359	HLA-C03:08	TSMQTLQDL	0.9986	0.8792	12	21
GPRC5B-C16orf96	chr16	19873158	chr16	4621561	1359	HLA-C03:19	VVLNGGTSM	0.9939	0.9935	6	15
GPRC5B-C16orf96	chr16	19873158	chr16	4621561	1359	HLA-C03:08	VVLNGGTSM	0.9935	0.9202	6	15
GPRC5B-C16orf96	chr16	19873158	chr16	4621561	1359	HLA-C03:07	VVLNGGTSM	0.9865	0.9871	6	15
GPRC5B-C16orf96	chr16	19873158	chr16	4621561	1359	HLA-C08:13	VVLNGGTSM	0.7437	0.9877	6	15
GPRC5B-C16orf96	chr16	19873158	chr16	4621561	1359	HLA-C08:04	VVLNGGTSM	0.7437	0.9877	6	15
GPRC5B-C16orf96	chr16	19873158	chr16	4621561	1359	HLA-C03:14	VVLNGGTSM	0.5779	0.9874	6	15
GPRC5B-C16orf96	chr16	19873158	chr16	4621561	1359	HLA-C03:04	TSMQTLQDL	0.9986	0.9857	12	21
GPRC5B-C16orf96	chr16	19873158	chr16	4621561	1359	HLA-C03:03	TSMQTLQDL	0.9986	0.9857	12	21
GPRC5B-C16orf96	chr16	19873158	chr16	4621561	1359	HLA-C03:17	TSMQTLQDL	0.9973	0.9723	12	21
GPRC5B-C16orf96	chr16	19873158	chr16	4621561	1359	HLA-C03:04	VVLNGGTSM	0.9958	0.9927	6	15
GPRC5B-C16orf96	chr16	19873158	chr16	4621561	1359	HLA-C03:03	VVLNGGTSM	0.9958	0.9927	6	15
GPRC5B-C16orf96	chr16	19873158	chr16	4621561	1359	HLA-C03:02	VVLNGGTSM	0.9919	0.9791	6	15
GPRC5B-C16orf96	chr16	19873158	chr16	4621561	1359	HLA-C03:05	VVLNGGTSM	0.9851	0.9366	6	15
GPRC5B-C16orf96	chr16	19873158	chr16	4621561	1359	HLA-C03:17	VVLNGGTSM	0.9829	0.9805	6	15
GPRC5B-C16orf96	chr16	19873158	chr16	4621561	1359	HLA-B15:39	VVLNGGTSM	0.9668	0.9074	6	15
GPRC5B-C16orf96	chr16	19873158	chr16	4621561	1359	HLA-B35:11	VVLNGGTSM	0.9563	0.9315	6	15
GPRC5B-C16orf96	chr16	19873158	chr16	4621561	1359	HLA-C12:02	VVLNGGTSM	0.9554	0.9862	6	15
GPRC5B-C16orf96	chr16	19873158	chr16	4621561	1359	HLA-C03:06	TSMQTLQDL	0.9522	0.9873	12	21
GPRC5B-C16orf96	chr16	19873158	chr16	4621561	1359	HLA-B07:13	VVLNGGTSM	0.8908	0.7721	6	15
GPRC5B-C16orf96	chr16	19873158	chr16	4621561	1359	HLA-C03:06	VVLNGGTSM	0.8863	0.9939	6	15
GPRC5B-C16orf96	chr16	19873158	chr16	4621561	1359	HLA-B15:73	VVLNGGTSM	0.7849	0.9184	6	15
GPRC5B-C16orf96	chr16	19873158	chr16	4621561	1359	HLA-B15:30	VVLNGGTSM	0.6714	0.9083	6	15
GPRC5B-C16orf96	chr16	19873158	chr16	4621561	1359	HLA-B35:13	VVLNGGTSM	0.5874	0.9271	6	15
GPRC5B-C16orf96	chr16	19873158	chr16	4621561	1359	HLA-B15:30	AVVLNGGTSM	0.9559	0.9474	5	15

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Potential FusionNeoAntigen Information of GPRC5B-C16orf96 in HLA II

GPRC5B-C16orf96_19873158_4621561.msa

Potential FusionNeoAntigen Information
* We used NetMHCIIpan v4.1 (%rank<0.5).

Fusion gene	Hchr	Hbp	Tgene	Tchr	Tbp	HLA II	FusionNeoAntigen peptide	Neoantigen start (at BP 13)	Neoantigen end (at BP 13)
GPRC5B-C16orf96	chr16	19873158	chr16	4621561	1359	DRB3-0301	TEMAVVLNGGTSMQT	2	17
GPRC5B-C16orf96	chr16	19873158	chr16	4621561	1359	DRB3-0301	EMAVVLNGGTSMQTL	3	18

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Fusion breakpoint peptide structures of GPRC5B-C16orf96

3D structures of the fusion breakpoint peptide of 14AA sequence that have potential fusion neoantigens
* The minimum length of the amino acid sequence in RoseTTAFold is 14AA. Here, we predicted the 14AA fusion protein breakpoint sequence not the fusion neoantigen peptide, which is shorter than 14 AA.

File name	BPseq	Hgene	Tgene	Hchr	Hbp	Tchr	Tbp	AAlen
10360	VVLNGGTSMQTLQD	GPRC5B	C16orf96	chr16	19873158	chr16	4621561	1359

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Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D of GPRC5B-C16orf96

Virtual screening between 25 HLAs (from PDB) and FusionNeoAntigens
* We used Glide to predict the interaction between HLAs and neoantigens.

HLA allele	PDB ID	File name	BPseq	Docking score	Glide score
HLA-B14:02	3BVN	10360	VVLNGGTSMQTLQD	-7.69222	-7.69942
HLA-B52:01	3W39	10360	VVLNGGTSMQTLQD	-7.60148	-7.60868
HLA-A11:01	4UQ2	10360	VVLNGGTSMQTLQD	-6.66327	-6.67047
HLA-A24:02	5HGA	10360	VVLNGGTSMQTLQD	-9.4375	-9.4447
HLA-B27:05	6PYJ	10360	VVLNGGTSMQTLQD	-4.77117	-4.77837
HLA-B44:05	3DX8	10360	VVLNGGTSMQTLQD	-6.68497	-6.69217
HLA-B35:01	1A1N	10360	VVLNGGTSMQTLQD	-4.9044	-4.9116

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Vaccine Design for the FusionNeoAntigens of GPRC5B-C16orf96

mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-Is.

Fusion gene	Hchr	Hbp	Tchr	Tbp	Start in +/-13AA	End in +/-13AA	FusionNeoAntigen peptide sequence	FusionNeoAntigen RNA sequence
GPRC5B-C16orf96	chr16	19873158	chr16	4621561	12	21	TSMQTLQDL	ACCTCAATGCAGACCCTGCAGGACTTG
GPRC5B-C16orf96	chr16	19873158	chr16	4621561	5	15	AVVLNGGTSM	GCCGTCGTGCTCAACGGTGGGACCTCAATG
GPRC5B-C16orf96	chr16	19873158	chr16	4621561	6	15	VVLNGGTSM	GTCGTGCTCAACGGTGGGACCTCAATG

mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-IIs.

Fusion gene	Hchr	Hbp	Tchr	Tbp	Start in +/-13AA	End in +/-13AA	FusionNeoAntigen peptide	FusionNEoAntigen RNA sequence
GPRC5B-C16orf96	chr16	19873158	chr16	4621561	2	17	TEMAVVLNGGTSMQT	ACTGAGATGGCCGTCGTGCTCAACGGTGGGACCTCAATGCAGACC
GPRC5B-C16orf96	chr16	19873158	chr16	4621561	3	18	EMAVVLNGGTSMQTL	GAGATGGCCGTCGTGCTCAACGGTGGGACCTCAATGCAGACCCTG

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Information of the samples that have these potential fusion neoantigens of GPRC5B-C16orf96

These samples were reported as having these fusion breakpoints. For individual breakpoints, we checked the open reading frames considering multiple gene isoforms and chose the in-frame fusion genes only. Then, we made fusion protein sequences and predicted the fusion neoantigens. These fusion-positive samples may have these potential fusion neoantigens.

Cancer type	Fusion gene	Hchr	Hbp	Henst	Tchr	Tbp	Tenst	Sample
BRCA	GPRC5B-C16orf96	chr16	19873158	ENST00000300571	chr16	4621561	ENST00000444310	TCGA-S3-AA0Z

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Potential target of CAR-T therapy development for GPRC5B-C16orf96

Predicted 3D structure. We used RoseTTAFold.

213_GPRC5B-C16orf96_t000_.e2e.pdb

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, to provide the retention of the transmembrane domain, we only show the protein feature retention information of those transmembrane features

* Minus value of BPloci means that the break point is located before the CDS.

- In-frame and retained 'Transmembrane'.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

GPRC5B

chr16:19873158

chr16:4621561

ENST00000300571

127_147

389

404.0

Transmembrane

Helical%3B Name%3D3

Hgene

GPRC5B

chr16:19873158

chr16:4621561

ENST00000300571

163_183

389

404.0

Transmembrane

Helical%3B Name%3D4

Hgene

GPRC5B

chr16:19873158

chr16:4621561

ENST00000300571

200_220

389

404.0

Transmembrane

Helical%3B Name%3D5

Hgene

GPRC5B

chr16:19873158

chr16:4621561

ENST00000300571

235_255

389

404.0

Transmembrane

Helical%3B Name%3D6

Hgene

GPRC5B

chr16:19873158

chr16:4621561

ENST00000300571

272_292

389

404.0

Transmembrane

Helical%3B Name%3D7

Hgene

GPRC5B

chr16:19873158

chr16:4621561

ENST00000300571

57_77

389

404.0

Transmembrane

Helical%3B Name%3D1

Hgene

GPRC5B

chr16:19873158

chr16:4621561

ENST00000300571

95_115

389

404.0

Transmembrane

Helical%3B Name%3D2

Hgene

GPRC5B

chr16:19873158

chr16:4621561

ENST00000535671

127_147

389

405.0

Transmembrane

Helical%3B Name%3D3

Hgene

GPRC5B

chr16:19873158

chr16:4621561

ENST00000535671

163_183

389

405.0

Transmembrane

Helical%3B Name%3D4

Hgene

GPRC5B

chr16:19873158

chr16:4621561

ENST00000535671

200_220

389

405.0

Transmembrane

Helical%3B Name%3D5

Hgene

GPRC5B

chr16:19873158

chr16:4621561

ENST00000535671

235_255

389

405.0

Transmembrane

Helical%3B Name%3D6

Hgene

GPRC5B

chr16:19873158

chr16:4621561

ENST00000535671

272_292

389

405.0

Transmembrane

Helical%3B Name%3D7

Hgene

GPRC5B

chr16:19873158

chr16:4621561

ENST00000535671

57_77

389

405.0

Transmembrane

Helical%3B Name%3D1

Hgene

GPRC5B

chr16:19873158

chr16:4621561

ENST00000535671

95_115

389

405.0

Transmembrane

Helical%3B Name%3D2

Hgene

GPRC5B

chr16:19873158

chr16:4621561

ENST00000569479

127_147

389

404.0

Transmembrane

Helical%3B Name%3D3

Hgene

GPRC5B

chr16:19873158

chr16:4621561

ENST00000569479

163_183

389

404.0

Transmembrane

Helical%3B Name%3D4

Hgene

GPRC5B

chr16:19873158

chr16:4621561

ENST00000569479

200_220

389

404.0

Transmembrane

Helical%3B Name%3D5

Hgene

GPRC5B

chr16:19873158

chr16:4621561

ENST00000569479

235_255

389

404.0

Transmembrane

Helical%3B Name%3D6

Hgene

GPRC5B

chr16:19873158

chr16:4621561

ENST00000569479

272_292

389

404.0

Transmembrane

Helical%3B Name%3D7

Hgene

GPRC5B

chr16:19873158

chr16:4621561

ENST00000569479

57_77

389

404.0

Transmembrane

Helical%3B Name%3D1

Hgene

GPRC5B

chr16:19873158

chr16:4621561

ENST00000569479

95_115

389

404.0

Transmembrane

Helical%3B Name%3D2

Hgene

GPRC5B

chr16:19873158

chr16:4621561

ENST00000569847

127_147

389

404.0

Transmembrane

Helical%3B Name%3D3

Hgene

GPRC5B

chr16:19873158

chr16:4621561

ENST00000569847

163_183

389

404.0

Transmembrane

Helical%3B Name%3D4

Hgene

GPRC5B

chr16:19873158

chr16:4621561

ENST00000569847

200_220

389

404.0

Transmembrane

Helical%3B Name%3D5

Hgene

GPRC5B

chr16:19873158

chr16:4621561

ENST00000569847

235_255

389

404.0

Transmembrane

Helical%3B Name%3D6

Hgene

GPRC5B

chr16:19873158

chr16:4621561

ENST00000569847

272_292

389

404.0

Transmembrane

Helical%3B Name%3D7

Hgene

GPRC5B

chr16:19873158

chr16:4621561

ENST00000569847

57_77

389

404.0

Transmembrane

Helical%3B Name%3D1

Hgene

GPRC5B

chr16:19873158

chr16:4621561

ENST00000569847

95_115

389

404.0

Transmembrane

Helical%3B Name%3D2

Hgene

GPRC5B

chr16:19873159

chr16:4621562

ENST00000300571

127_147

389

404.0

Transmembrane

Helical%3B Name%3D3

Hgene

GPRC5B

chr16:19873159

chr16:4621562

ENST00000300571

163_183

389

404.0

Transmembrane

Helical%3B Name%3D4

Hgene

GPRC5B

chr16:19873159

chr16:4621562

ENST00000300571

200_220

389

404.0

Transmembrane

Helical%3B Name%3D5

Hgene

GPRC5B

chr16:19873159

chr16:4621562

ENST00000300571

235_255

389

404.0

Transmembrane

Helical%3B Name%3D6

Hgene

GPRC5B

chr16:19873159

chr16:4621562

ENST00000300571

272_292

389

404.0

Transmembrane

Helical%3B Name%3D7

Hgene

GPRC5B

chr16:19873159

chr16:4621562

ENST00000300571

57_77

389

404.0

Transmembrane

Helical%3B Name%3D1

Hgene

GPRC5B

chr16:19873159

chr16:4621562

ENST00000300571

95_115

389

404.0

Transmembrane

Helical%3B Name%3D2

Hgene

GPRC5B

chr16:19873159

chr16:4621562

ENST00000535671

127_147

389

405.0

Transmembrane

Helical%3B Name%3D3

Hgene

GPRC5B

chr16:19873159

chr16:4621562

ENST00000535671

163_183

389

405.0

Transmembrane

Helical%3B Name%3D4

Hgene

GPRC5B

chr16:19873159

chr16:4621562

ENST00000535671

200_220

389

405.0

Transmembrane

Helical%3B Name%3D5

Hgene

GPRC5B

chr16:19873159

chr16:4621562

ENST00000535671

235_255

389

405.0

Transmembrane

Helical%3B Name%3D6

Hgene

GPRC5B

chr16:19873159

chr16:4621562

ENST00000535671

272_292

389

405.0

Transmembrane

Helical%3B Name%3D7

Hgene

GPRC5B

chr16:19873159

chr16:4621562

ENST00000535671

57_77

389

405.0

Transmembrane

Helical%3B Name%3D1

Hgene

GPRC5B

chr16:19873159

chr16:4621562

ENST00000535671

95_115

389

405.0

Transmembrane

Helical%3B Name%3D2

Hgene

GPRC5B

chr16:19873159

chr16:4621562

ENST00000569479

127_147

389

404.0

Transmembrane

Helical%3B Name%3D3

Hgene

GPRC5B

chr16:19873159

chr16:4621562

ENST00000569479

163_183

389

404.0

Transmembrane

Helical%3B Name%3D4

Hgene

GPRC5B

chr16:19873159

chr16:4621562

ENST00000569479

200_220

389

404.0

Transmembrane

Helical%3B Name%3D5

Hgene

GPRC5B

chr16:19873159

chr16:4621562

ENST00000569479

235_255

389

404.0

Transmembrane

Helical%3B Name%3D6

Hgene

GPRC5B

chr16:19873159

chr16:4621562

ENST00000569479

272_292

389

404.0

Transmembrane

Helical%3B Name%3D7

Hgene

GPRC5B

chr16:19873159

chr16:4621562

ENST00000569479

57_77

389

404.0

Transmembrane

Helical%3B Name%3D1

Hgene

GPRC5B

chr16:19873159

chr16:4621562

ENST00000569479

95_115

389

404.0

Transmembrane

Helical%3B Name%3D2

Hgene

GPRC5B

chr16:19873159

chr16:4621562

ENST00000569847

127_147

389

404.0

Transmembrane

Helical%3B Name%3D3

Hgene

GPRC5B

chr16:19873159

chr16:4621562

ENST00000569847

163_183

389

404.0

Transmembrane

Helical%3B Name%3D4

Hgene

GPRC5B

chr16:19873159

chr16:4621562

ENST00000569847

200_220

389

404.0

Transmembrane

Helical%3B Name%3D5

Hgene

GPRC5B

chr16:19873159

chr16:4621562

ENST00000569847

235_255

389

404.0

Transmembrane

Helical%3B Name%3D6

Hgene

GPRC5B

chr16:19873159

chr16:4621562

ENST00000569847

272_292

389

404.0

Transmembrane

Helical%3B Name%3D7

Hgene

GPRC5B

chr16:19873159

chr16:4621562

ENST00000569847

57_77

389

404.0

Transmembrane

Helical%3B Name%3D1

Hgene

GPRC5B

chr16:19873159

chr16:4621562

ENST00000569847

95_115

389

404.0

Transmembrane

Helical%3B Name%3D2

Subcellular localization prediction of the transmembrane domain retained fusion proteins
* We used DeepLoc 1.0. The order of the X-axis of the barplot is as follows: Entry_ID, Localization, Type, Nucleus, Cytoplasm, Extracellular, Mitochondrion, Cell_membrane, Endoplasmic_reticulum, Plastid, Golgi.apparatus, Lysosome.Vacuole, Peroxisome. Y-axis is the output score of DeepLoc. Clicking the image will open a new tab with a large image.

Hgene	Hchr	Hbp	Henst	Tgene	Tchr	Tbp	Tenst	DeepLoc result
GPRC5B	chr16	19873158	ENST00000300571	C16orf96	chr16	4621561	ENST00000444310
GPRC5B	chr16	19873158	ENST00000535671	C16orf96	chr16	4621561	ENST00000444310
GPRC5B	chr16	19873158	ENST00000537135	C16orf96	chr16	4621561	ENST00000444310

Top

Related Drugs to GPRC5B-C16orf96

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to GPRC5B-C16orf96

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source

	Fusion Gene and Fusion Protein Summary
	Fusion Amino Acid Sequences (multiple BPs and multiple gene isoforms)
	Fusion Protein Breakpoint Sequences - (for the Screening of the FusionNeoAntigens)
	Potential FusionNeoAntigens in HLA I - (netMHCpan v4.1 + deepHLApan v1.1)
	Potential FusionNeoAntigens in HLA II - (netMHCIIpan v4.1)
	Fusion Breakpoint 14 AA Peptide Structure - (RoseTTAFold)
	Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D - (Glide)
	Vaccine Design for the FusionNeoAntigens (RNA/protein sequences)
	Potential target of CAR-T therapy development
	Information on the samples that have these potential fusion neoantigens
	Fusion Protein Targeting Drugs - (Manual Curation)
	Fusion Protein Related diseases - (Manual Curation)