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Fusion Protein:IDO1-TAX1BP1

Fusion Gene and Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: IDO1-TAX1BP1
	FusionPDB ID: 38269
	FusionGDB2.0 ID: 38269
		Hgene	Tgene
	Gene symbol	IDO1	TAX1BP1
	Gene ID	3620	8887
	Gene name	indoleamine 2,3-dioxygenase 1	Tax1 binding protein 1
	Synonyms	IDO\|IDO-1\|INDO	CALCOCO3\|T6BP\|TXBP151
	Cytomap	8p11.21	7p15.2
	Type of gene	protein-coding	protein-coding
	Description	indoleamine 2,3-dioxygenase 1indolamine 2,3 dioxygenaseindole 2,3-dioxygenaseindoleamine-pyrrole 2,3-dioxygenase	tax1-binding protein 1TRAF6-binding proteinTax1 (human T-cell leukemia virus type I) binding protein 1
	Modification date	20200322	20200327
	UniProtAcc	P14902 Main function of 5'-partner protein: FUNCTION: Catalyzes the first and rate limiting step of the catabolism of the essential amino acid tryptophan along the kynurenine pathway (PubMed:17671174). Involved in the peripheral immune tolerance, contributing to maintain homeostasis by preventing autoimmunity or immunopathology that would result from uncontrolled and overreacting immune responses (PubMed:25691885). Tryptophan shortage inhibits T lymphocytes division and accumulation of tryptophan catabolites induces T-cell apoptosis and differentiation of regulatory T-cells (PubMed:25691885). Acts as a suppressor of anti-tumor immunity (PubMed:23103127, PubMed:25157255, PubMed:14502282, PubMed:25691885). Limits the growth of intracellular pathogens by depriving tryptophan (PubMed:25691885). Protects the fetus from maternal immune rejection (PubMed:25691885). {ECO:0000269\|PubMed:14502282, ECO:0000269\|PubMed:17671174, ECO:0000303\|PubMed:23103127, ECO:0000303\|PubMed:25157255, ECO:0000303\|PubMed:25691885}.	.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000518237, ENST00000522495,	ENST00000494033, ENST00000265393, ENST00000396319, ENST00000409980, ENST00000433216, ENST00000543117,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	3 X 3 X 2=18	22 X 14 X 9=2772
	# samples	3	26
	** MAII score	log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0	log2(26/2772*10)=-3.41434372910876 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Fusion gene context	PubMed: IDO1 [Title/Abstract] AND TAX1BP1 [Title/Abstract] AND fusion [Title/Abstract]
Fusion neoantigen context	PubMed: IDO1 [Title/Abstract] AND TAX1BP1 [Title/Abstract] AND neoantigen [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	IDO1(39771528)-TAX1BP1(27855967), # samples:1
Anticipated loss of major functional domain due to fusion event.	IDO1-TAX1BP1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. IDO1-TAX1BP1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. IDO1-TAX1BP1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. IDO1-TAX1BP1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:39771528/chr7:27855967)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Retention analysis results of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features, are available here.

Fusion gene breakpoints across IDO1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across TAX1BP1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Amino Acid Sequences

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000522495	IDO1	chr8	39771528	+	ENST00000543117	TAX1BP1	chr7	27855967	+	1087	343	256	822	188
ENST00000522495	IDO1	chr8	39771528	+	ENST00000265393	TAX1BP1	chr7	27855967	+	875	343	256	822	188
ENST00000522495	IDO1	chr8	39771528	+	ENST00000409980	TAX1BP1	chr7	27855967	+	1001	343	256	948	230
ENST00000522495	IDO1	chr8	39771528	+	ENST00000433216	TAX1BP1	chr7	27855967	+	858	343	256	822	188
ENST00000522495	IDO1	chr8	39771528	+	ENST00000396319	TAX1BP1	chr7	27855967	+	1381	343	256	948	230
ENST00000518237	IDO1	chr8	39771528	+	ENST00000543117	TAX1BP1	chr7	27855967	+	1470	726	639	1205	188
ENST00000518237	IDO1	chr8	39771528	+	ENST00000265393	TAX1BP1	chr7	27855967	+	1258	726	639	1205	188
ENST00000518237	IDO1	chr8	39771528	+	ENST00000409980	TAX1BP1	chr7	27855967	+	1384	726	639	1331	230
ENST00000518237	IDO1	chr8	39771528	+	ENST00000433216	TAX1BP1	chr7	27855967	+	1241	726	639	1205	188
ENST00000518237	IDO1	chr8	39771528	+	ENST00000396319	TAX1BP1	chr7	27855967	+	1764	726	639	1331	230

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000522495	ENST00000543117	IDO1	chr8	39771528	+	TAX1BP1	chr7	27855967	+	0.000485869	0.9995141
ENST00000522495	ENST00000265393	IDO1	chr8	39771528	+	TAX1BP1	chr7	27855967	+	0.000562953	0.99943703
ENST00000522495	ENST00000409980	IDO1	chr8	39771528	+	TAX1BP1	chr7	27855967	+	0.000640684	0.9993593
ENST00000522495	ENST00000433216	IDO1	chr8	39771528	+	TAX1BP1	chr7	27855967	+	0.00059659	0.99940336
ENST00000522495	ENST00000396319	IDO1	chr8	39771528	+	TAX1BP1	chr7	27855967	+	0.000445611	0.99955434
ENST00000518237	ENST00000543117	IDO1	chr8	39771528	+	TAX1BP1	chr7	27855967	+	0.000452627	0.9995473
ENST00000518237	ENST00000265393	IDO1	chr8	39771528	+	TAX1BP1	chr7	27855967	+	0.000465273	0.9995347
ENST00000518237	ENST00000409980	IDO1	chr8	39771528	+	TAX1BP1	chr7	27855967	+	0.000519722	0.9994803
ENST00000518237	ENST00000433216	IDO1	chr8	39771528	+	TAX1BP1	chr7	27855967	+	0.000495623	0.9995043
ENST00000518237	ENST00000396319	IDO1	chr8	39771528	+	TAX1BP1	chr7	27855967	+	0.000446708	0.99955326

Predicted full-length fusion amino acid sequences. For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among all the predicted ones.

Get the fusion protein sequences from here.

Fusion protein sequence information is available in the fasta format.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

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Fusion Protein Breakpoint Sequences for IDO1-TAX1BP1

+/-13 AA sequence from the breakpoints of the fusion protein sequences.

Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	Length(fusion protein)	BP in fusion protein	Peptide
IDO1	chr8	39771528	TAX1BP1	chr7	27855967	343	29	IDEEVGFALPNPQELKRSLENPAERK
IDO1	chr8	39771528	TAX1BP1	chr7	27855967	726	29	IDEEVGFALPNPQELKRSLENPAERK

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Potential FusionNeoAntigen Information of IDO1-TAX1BP1 in HLA I

Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.

IDO1-TAX1BP1_39771528_27855967.msa

Potential FusionNeoAntigen Information
* We used NetMHCpan v4.1 (%rank<0.5) and deepHLApan v1.1 (immunogenic score>0.5)

Fusion gene	Hchr	Hbp	Tgene	Tchr	Tbp	HLA I	FusionNeoAntigen peptide	Binding score	Immunogenic score	Neoantigen start (at BP 13)	Neoantigen end (at BP 13)
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-B35:03	FALPNPQEL	0.9945	0.8926	6	15
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-B35:08	FALPNPQEL	0.9938	0.9014	6	15
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-B15:10	FALPNPQEL	0.991	0.7166	6	15
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-B35:05	FALPNPQEL	0.9894	0.6978	6	15
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-B52:01	FALPNPQEL	0.9891	0.984	6	15
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-B15:18	FALPNPQEL	0.9886	0.8466	6	15
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-B35:01	FALPNPQEL	0.9879	0.9293	6	15
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-B08:01	NPQELKRSL	0.986	0.6794	10	19
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-B39:24	FALPNPQEL	0.9835	0.5118	6	15
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-B35:04	FALPNPQEL	0.9833	0.9524	6	15
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-B35:02	FALPNPQEL	0.9833	0.9524	6	15
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-B14:02	FALPNPQEL	0.9828	0.9193	6	15
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-B14:01	FALPNPQEL	0.9828	0.9193	6	15
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-B51:01	FALPNPQEL	0.978	0.6942	6	15
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-B15:16	FALPNPQEL	0.9725	0.7915	6	15
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-B08:09	NPQELKRSL	0.967	0.6608	10	19
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-B35:01	NPQELKRSL	0.9599	0.7525	10	19
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-B35:08	NPQELKRSL	0.9571	0.8038	10	19
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-B39:01	FALPNPQEL	0.9551	0.9535	6	15
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-B35:03	NPQELKRSL	0.9546	0.79	10	19
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-A02:21	FALPNPQEL	0.9439	0.6929	6	15
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-A02:04	FALPNPQEL	0.9354	0.7096	6	15
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-A02:30	FALPNPQEL	0.9351	0.5846	6	15
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-A02:24	FALPNPQEL	0.9351	0.5846	6	15
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-A02:67	FALPNPQEL	0.9351	0.5846	6	15
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-A02:60	FALPNPQEL	0.9331	0.5716	6	15
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-A02:17	FALPNPQEL	0.9326	0.5295	6	15
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-B15:37	FALPNPQEL	0.9303	0.7193	6	15
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-A02:29	FALPNPQEL	0.9197	0.584	6	15
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-A02:11	FALPNPQEL	0.9189	0.6382	6	15
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-A02:20	FALPNPQEL	0.9137	0.5923	6	15
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-A02:22	FALPNPQEL	0.9034	0.6073	6	15
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-B39:13	FALPNPQEL	0.8941	0.965	6	15
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-A02:35	FALPNPQEL	0.8918	0.6066	6	15
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-B35:02	NPQELKRSL	0.8086	0.714	10	19
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-B35:04	NPQELKRSL	0.8086	0.714	10	19
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-A02:38	FALPNPQEL	0.7382	0.6114	6	15
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-B08:01	FALPNPQEL	0.696	0.6039	6	15
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-A02:16	FALPNPQEL	0.6559	0.5971	6	15
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-B08:09	FALPNPQEL	0.6328	0.6911	6	15
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-A02:27	FALPNPQEL	0.6183	0.5778	6	15
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-A02:13	FALPNPQEL	0.5542	0.7161	6	15
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-B13:01	FALPNPQEL	0.5073	0.9426	6	15
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-B35:03	LPNPQELKRSL	0.9921	0.7927	8	19
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-B35:02	LPNPQELKRSL	0.9765	0.8349	8	19
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-B35:04	LPNPQELKRSL	0.9765	0.8349	8	19
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-C01:17	ALPNPQEL	0.9791	0.9677	7	15
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-C01:30	ALPNPQEL	0.9177	0.9703	7	15
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-C03:08	FALPNPQEL	0.9999	0.9394	6	15
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-C03:19	FALPNPQEL	0.9999	0.9955	6	15
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-C03:07	FALPNPQEL	0.9999	0.9879	6	15
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-C15:06	FALPNPQEL	0.9998	0.9453	6	15
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-C15:04	FALPNPQEL	0.9998	0.9473	6	15
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-C04:06	FALPNPQEL	0.9996	0.9161	6	15
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-C08:04	FALPNPQEL	0.9993	0.9888	6	15
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-C08:13	FALPNPQEL	0.9993	0.9888	6	15
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-C03:14	FALPNPQEL	0.9987	0.9921	6	15
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-C12:16	FALPNPQEL	0.9983	0.9864	6	15
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-C12:12	FALPNPQEL	0.998	0.9757	6	15
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-C06:03	FALPNPQEL	0.9977	0.9967	6	15
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-C08:03	FALPNPQEL	0.9973	0.9942	6	15
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-C12:04	FALPNPQEL	0.9972	0.9962	6	15
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-C07:05	FALPNPQEL	0.9954	0.9805	6	15
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-C05:09	FALPNPQEL	0.9952	0.9467	6	15
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-C04:14	FALPNPQEL	0.9949	0.8944	6	15
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-C07:13	FALPNPQEL	0.9943	0.9595	6	15
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-C07:46	FALPNPQEL	0.9933	0.9474	6	15
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-C04:10	FALPNPQEL	0.9932	0.8238	6	15
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-C07:10	FALPNPQEL	0.9931	0.9834	6	15
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-C07:27	FALPNPQEL	0.9929	0.9773	6	15
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-B42:02	NPQELKRSL	0.9927	0.6814	10	19
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-C04:07	FALPNPQEL	0.9918	0.8266	6	15
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-C07:80	FALPNPQEL	0.9915	0.9818	6	15
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-C07:67	FALPNPQEL	0.9915	0.9818	6	15
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-C07:29	FALPNPQEL	0.9904	0.9619	6	15
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-B42:01	NPQELKRSL	0.989	0.6731	10	19
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-B15:21	FALPNPQEL	0.9874	0.9513	6	15
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-C08:15	FALPNPQEL	0.9864	0.9594	6	15
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-B15:31	FALPNPQEL	0.985	0.9357	6	15
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-C07:95	FALPNPQEL	0.9833	0.8054	6	15
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-B35:12	FALPNPQEL	0.9833	0.9524	6	15
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-B51:07	FALPNPQEL	0.9824	0.965	6	15
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-C07:19	FALPNPQEL	0.9823	0.8769	6	15
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-B39:08	FALPNPQEL	0.981	0.8048	6	15
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-C02:06	FALPNPQEL	0.9807	0.9873	6	15
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-C01:17	FALPNPQEL	0.9771	0.9569	6	15
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-B39:09	FALPNPQEL	0.9765	0.7389	6	15
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-B78:01	FALPNPQEL	0.9693	0.7966	6	15
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-B39:10	FALPNPQEL	0.961	0.9459	6	15
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-B14:03	NPQELKRSL	0.9514	0.6935	10	19
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-B39:12	FALPNPQEL	0.9474	0.9568	6	15
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-A02:07	FALPNPQEL	0.9392	0.5968	6	15
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-A02:01	FALPNPQEL	0.9351	0.5846	6	15
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-A02:05	FALPNPQEL	0.9153	0.522	6	15
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-B14:03	FALPNPQEL	0.9112	0.8507	6	15
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-C01:30	FALPNPQEL	0.8932	0.9616	6	15
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-B42:02	FALPNPQEL	0.8613	0.6037	6	15
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-B39:05	FALPNPQEL	0.85	0.9488	6	15
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-B35:12	NPQELKRSL	0.8086	0.714	10	19
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-B39:10	NPQELKRSL	0.7931	0.7789	10	19
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-B51:08	FALPNPQEL	0.6411	0.5259	6	15
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-C03:19	GFALPNPQEL	0.9329	0.9938	5	15
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-C03:19	FALPNPQELK	0.8327	0.9888	6	16
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-B07:12	LPNPQELKRSL	0.9994	0.5578	8	19
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-B42:02	LPNPQELKRSL	0.9962	0.7969	8	19
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-B42:01	LPNPQELKRSL	0.9957	0.7871	8	19
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-B35:12	LPNPQELKRSL	0.9765	0.8349	8	19
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-B39:10	LPNPQELKRSL	0.9588	0.8591	8	19
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-C01:03	ALPNPQEL	0.9931	0.9417	7	15
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-C01:02	ALPNPQEL	0.9889	0.9661	7	15
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-C03:67	FALPNPQEL	0.9999	0.9903	6	15
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-C03:02	FALPNPQEL	0.9999	0.9876	6	15
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-C03:03	FALPNPQEL	0.9999	0.9952	6	15
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-C03:04	FALPNPQEL	0.9999	0.9952	6	15
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-C15:09	FALPNPQEL	0.9998	0.9473	6	15
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-C03:17	FALPNPQEL	0.9998	0.986	6	15
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-C03:05	FALPNPQEL	0.9998	0.9705	6	15
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-C15:02	FALPNPQEL	0.9997	0.9244	6	15
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-C15:05	FALPNPQEL	0.9997	0.9168	6	15
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-C12:02	FALPNPQEL	0.9995	0.9889	6	15
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-C16:04	FALPNPQEL	0.9993	0.9928	6	15
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-C12:03	FALPNPQEL	0.9993	0.9919	6	15
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-C03:06	FALPNPQEL	0.9992	0.9959	6	15
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-C04:04	FALPNPQEL	0.9992	0.9079	6	15
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-C06:17	FALPNPQEL	0.9977	0.9959	6	15
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-C06:02	FALPNPQEL	0.9977	0.9959	6	15
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-C08:01	FALPNPQEL	0.9973	0.9942	6	15
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-C16:01	FALPNPQEL	0.9971	0.9873	6	15
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-C16:02	FALPNPQEL	0.9959	0.9948	6	15
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-C04:03	FALPNPQEL	0.9954	0.8436	6	15
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-C14:02	FALPNPQEL	0.9952	0.961	6	15
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-C05:01	FALPNPQEL	0.9952	0.9467	6	15
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-C14:03	FALPNPQEL	0.9952	0.961	6	15
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-B35:13	FALPNPQEL	0.9942	0.8967	6	15
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-C18:01	FALPNPQEL	0.9942	0.8359	6	15
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-C04:01	FALPNPQEL	0.9918	0.8266	6	15
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-C01:03	FALPNPQEL	0.9915	0.9349	6	15
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-C07:02	FALPNPQEL	0.9915	0.9818	6	15
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-C07:04	FALPNPQEL	0.9913	0.9157	6	15
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-C07:22	FALPNPQEL	0.9904	0.7979	6	15
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-C07:17	FALPNPQEL	0.9899	0.986	6	15
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-B35:17	FALPNPQEL	0.9898	0.854	6	15
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-B35:30	FALPNPQEL	0.9898	0.854	6	15
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-B35:77	FALPNPQEL	0.9879	0.9293	6	15
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-B35:23	FALPNPQEL	0.9875	0.9054	6	15
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-C06:06	FALPNPQEL	0.9873	0.9927	6	15
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-B35:11	FALPNPQEL	0.9867	0.9366	6	15
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-C08:02	FALPNPQEL	0.9864	0.9594	6	15
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-B08:18	NPQELKRSL	0.986	0.6794	10	19
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-C02:02	FALPNPQEL	0.9855	0.9899	6	15
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-C02:10	FALPNPQEL	0.9855	0.9899	6	15
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-C07:01	FALPNPQEL	0.9852	0.7883	6	15
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-B35:20	FALPNPQEL	0.9849	0.9552	6	15
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-B56:05	FALPNPQEL	0.9837	0.5252	6	15
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-B35:09	FALPNPQEL	0.9833	0.9524	6	15
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-B78:02	FALPNPQEL	0.9813	0.9099	6	15
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-B15:73	FALPNPQEL	0.9811	0.9077	6	15
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-B35:28	FALPNPQEL	0.9806	0.9529	6	15
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-C01:02	FALPNPQEL	0.9797	0.9564	6	15
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-B15:30	FALPNPQEL	0.9786	0.9131	6	15
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-B39:11	FALPNPQEL	0.9779	0.7863	6	15
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-B67:01	FALPNPQEL	0.9726	0.764	6	15
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-B51:14	FALPNPQEL	0.9682	0.6283	6	15
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-C06:08	FALPNPQEL	0.9622	0.9947	6	15
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-B15:13	FALPNPQEL	0.9618	0.8374	6	15
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-B51:06	FALPNPQEL	0.9612	0.6606	6	15
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-B39:02	FALPNPQEL	0.9604	0.9617	6	15
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-B39:31	FALPNPQEL	0.9604	0.9542	6	15
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-B35:77	NPQELKRSL	0.9599	0.7525	10	19
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-B35:23	NPQELKRSL	0.9569	0.6594	10	19
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-C17:01	FALPNPQEL	0.9564	0.9557	6	15
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-B15:11	FALPNPQEL	0.9463	0.9143	6	15
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-A02:14	FALPNPQEL	0.9459	0.6607	6	15
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-B15:08	FALPNPQEL	0.9453	0.9048	6	15
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-B51:09	FALPNPQEL	0.9444	0.6975	6	15
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-B51:21	FALPNPQEL	0.9442	0.665	6	15
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-A02:06	FALPNPQEL	0.9439	0.6929	6	15
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-B35:43	FALPNPQEL	0.9429	0.9039	6	15
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-B58:06	FALPNPQEL	0.9423	0.9209	6	15
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-B15:09	FALPNPQEL	0.9279	0.6685	6	15
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-B35:11	NPQELKRSL	0.9108	0.7377	10	19
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-B35:30	NPQELKRSL	0.8623	0.5766	10	19
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-B35:17	NPQELKRSL	0.8623	0.5766	10	19
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-A69:01	FALPNPQEL	0.8429	0.7522	6	15
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-B35:24	NPQELKRSL	0.8368	0.7328	10	19
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-B08:12	NPQELKRSL	0.8305	0.8148	10	19
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-B08:12	FALPNPQEL	0.8186	0.7374	6	15
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-B35:09	NPQELKRSL	0.8086	0.714	10	19
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-B67:01	NPQELKRSL	0.7903	0.5841	10	19
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-B35:24	FALPNPQEL	0.7875	0.9363	6	15
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-B07:13	FALPNPQEL	0.7516	0.8643	6	15
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-B08:18	FALPNPQEL	0.696	0.6039	6	15
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-B53:02	FALPNPQEL	0.685	0.6721	6	15
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-B18:07	FALPNPQEL	0.0872	0.9129	6	15
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-B18:07	NPQELKRSL	0.0833	0.7547	10	19
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-B35:43	NPQELKRSL	0.0324	0.6784	10	19
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-C03:04	GFALPNPQEL	0.9521	0.992	5	15
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-C03:03	GFALPNPQEL	0.9521	0.992	5	15
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-C03:04	FALPNPQELK	0.8613	0.9887	6	16
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-C03:03	FALPNPQELK	0.8613	0.9887	6	16
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-C03:06	GFALPNPQEL	0.7118	0.9931	5	15
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-C03:06	FALPNPQELK	0.6255	0.9888	6	16
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-B35:13	GFALPNPQEL	0.4075	0.8797	5	15
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-C03:04	VGFALPNPQEL	0.998	0.9918	4	15
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-C03:03	VGFALPNPQEL	0.998	0.9918	4	15
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-B35:13	LPNPQELKRSL	0.9938	0.7986	8	19
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-C03:06	VGFALPNPQEL	0.9795	0.9923	4	15
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-B35:09	LPNPQELKRSL	0.9765	0.8349	8	19
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	HLA-B67:01	LPNPQELKRSL	0.9705	0.6569	8	19

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Potential FusionNeoAntigen Information of IDO1-TAX1BP1 in HLA II

IDO1-TAX1BP1_39771528_27855967.msa

Potential FusionNeoAntigen Information
* We used NetMHCIIpan v4.1 (%rank<0.5).

Fusion gene	Hchr	Hbp	Tgene	Tchr	Tbp	HLA II	FusionNeoAntigen peptide	Neoantigen start (at BP 13)	Neoantigen end (at BP 13)
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	726	DRB1-0906	PQELKRSLENPAERK	11	26

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Fusion breakpoint peptide structures of IDO1-TAX1BP1

3D structures of the fusion breakpoint peptide of 14AA sequence that have potential fusion neoantigens
* The minimum length of the amino acid sequence in RoseTTAFold is 14AA. Here, we predicted the 14AA fusion protein breakpoint sequence not the fusion neoantigen peptide, which is shorter than 14 AA.

File name	BPseq	Hgene	Tgene	Hchr	Hbp	Tchr	Tbp	AAlen
2293	FALPNPQELKRSLE	IDO1	TAX1BP1	chr8	39771528	chr7	27855967	726

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Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D of IDO1-TAX1BP1

Virtual screening between 25 HLAs (from PDB) and FusionNeoAntigens
* We used Glide to predict the interaction between HLAs and neoantigens.

HLA allele	PDB ID	File name	BPseq	Docking score	Glide score
HLA-B14:02	3BVN	2293	FALPNPQELKRSLE	-8.55667	-8.74867
HLA-B14:02	3BVN	2293	FALPNPQELKRSLE	-3.49457	-4.25557
HLA-B52:01	3W39	2293	FALPNPQELKRSLE	-7.26725	-7.45925
HLA-B52:01	3W39	2293	FALPNPQELKRSLE	-4.01461	-4.77561
HLA-A24:02	5HGA	2293	FALPNPQELKRSLE	-7.65911	-8.42011
HLA-A24:02	5HGA	2293	FALPNPQELKRSLE	-7.10204	-7.29404
HLA-B44:05	3DX8	2293	FALPNPQELKRSLE	-7.5556	-8.3166
HLA-B44:05	3DX8	2293	FALPNPQELKRSLE	-2.76159	-2.95359

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Vaccine Design for the FusionNeoAntigens of IDO1-TAX1BP1

mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-Is.

Fusion gene	Hchr	Hbp	Tchr	Tbp	Start in +/-13AA	End in +/-13AA	FusionNeoAntigen peptide sequence	FusionNeoAntigen RNA sequence
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	10	19	NPQELKRSL	AATCCACAGGAACTTAAAAGGAGTCTA
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	4	15	VGFALPNPQEL	GTGGGCTTTGCTCTGCCAAATCCACAGGAACTT
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	5	15	GFALPNPQEL	GGCTTTGCTCTGCCAAATCCACAGGAACTT
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	6	15	FALPNPQEL	TTTGCTCTGCCAAATCCACAGGAACTT
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	6	16	FALPNPQELK	TTTGCTCTGCCAAATCCACAGGAACTTAAA
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	7	15	ALPNPQEL	GCTCTGCCAAATCCACAGGAACTT
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	8	19	LPNPQELKRSL	CTGCCAAATCCACAGGAACTTAAAAGGAGTCTA

mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-IIs.

Fusion gene	Hchr	Hbp	Tchr	Tbp	Start in +/-13AA	End in +/-13AA	FusionNeoAntigen peptide	FusionNEoAntigen RNA sequence
IDO1-TAX1BP1	chr8	39771528	chr7	27855967	11	26	PQELKRSLENPAERK	CCACAGGAACTTAAAAGGAGTCTAGAAAATCCAGCAGAAAGGAAA

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Information of the samples that have these potential fusion neoantigens of IDO1-TAX1BP1

These samples were reported as having these fusion breakpoints. For individual breakpoints, we checked the open reading frames considering multiple gene isoforms and chose the in-frame fusion genes only. Then, we made fusion protein sequences and predicted the fusion neoantigens. These fusion-positive samples may have these potential fusion neoantigens.

Cancer type	Fusion gene	Hchr	Hbp	Henst	Tchr	Tbp	Tenst	Sample
STAD	IDO1-TAX1BP1	chr8	39771528	ENST00000518237	chr7	27855967	ENST00000265393	TCGA-D7-A4YX

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Potential target of CAR-T therapy development for IDO1-TAX1BP1

Predicted 3D structure. We used RoseTTAFold.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, to provide the retention of the transmembrane domain, we only show the protein feature retention information of those transmembrane features

* Minus value of BPloci means that the break point is located before the CDS.

- In-frame and retained 'Transmembrane'.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Subcellular localization prediction of the transmembrane domain retained fusion proteins
* We used DeepLoc 1.0. The order of the X-axis of the barplot is as follows: Entry_ID, Localization, Type, Nucleus, Cytoplasm, Extracellular, Mitochondrion, Cell_membrane, Endoplasmic_reticulum, Plastid, Golgi.apparatus, Lysosome.Vacuole, Peroxisome. Y-axis is the output score of DeepLoc. Clicking the image will open a new tab with a large image.

Hgene

Hchr

Hbp

Henst

Tgene

Tchr

Tbp

Tenst

DeepLoc result

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Related Drugs to IDO1-TAX1BP1

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to IDO1-TAX1BP1

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source

	Fusion Gene and Fusion Protein Summary
	Fusion Amino Acid Sequences (multiple BPs and multiple gene isoforms)
	Fusion Protein Breakpoint Sequences - (for the Screening of the FusionNeoAntigens)
	Potential FusionNeoAntigens in HLA I - (netMHCpan v4.1 + deepHLApan v1.1)
	Potential FusionNeoAntigens in HLA II - (netMHCIIpan v4.1)
	Fusion Breakpoint 14 AA Peptide Structure - (RoseTTAFold)
	Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D - (Glide)
	Vaccine Design for the FusionNeoAntigens (RNA/protein sequences)
	Potential target of CAR-T therapy development
	Information on the samples that have these potential fusion neoantigens
	Fusion Protein Targeting Drugs - (Manual Curation)
	Fusion Protein Related diseases - (Manual Curation)