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Fusion Protein:IKZF1-B2M

Fusion Gene and Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: IKZF1-B2M
	FusionPDB ID: 39386
	FusionGDB2.0 ID: 39386
		Hgene	Tgene
	Gene symbol	IKZF1	B2M
	Gene ID	10320	567
	Gene name	IKAROS family zinc finger 1	beta-2-microglobulin
	Synonyms	CVID13\|Hs.54452\|IK1\|IKAROS\|LYF1\|LyF-1\|PPP1R92\|PRO0758\|ZNFN1A1	IMD43
	Cytomap	7p12.2	15q21.1
	Type of gene	protein-coding	protein-coding
	Description	DNA-binding protein IkarosCLL-associated antigen KW-6ikaros family zinc finger protein 1lymphoid transcription factor LyF-1protein phosphatase 1, regulatory subunit 92zinc finger protein, subfamily 1A, 1 (Ikaros)	beta-2-microglobulinbeta chain of MHC class I moleculesbeta-2-microglobin
	Modification date	20200329	20200329
	UniProtAcc	Q13422 Main function of 5'-partner protein: FUNCTION: Transcription regulator of hematopoietic cell differentiation (PubMed:17934067). Binds gamma-satellite DNA (PubMed:17135265, PubMed:19141594). Plays a role in the development of lymphocytes, B- and T-cells. Binds and activates the enhancer (delta-A element) of the CD3-delta gene. Repressor of the TDT (fikzfterminal deoxynucleotidyltransferase) gene during thymocyte differentiation. Regulates transcription through association with both HDAC-dependent and HDAC-independent complexes. Targets the 2 chromatin-remodeling complexes, NuRD and BAF (SWI/SNF), in a single complex (PYR complex), to the beta-globin locus in adult erythrocytes. Increases normal apoptosis in adult erythroid cells. Confers early temporal competence to retinal progenitor cells (RPCs) (By similarity). Function is isoform-specific and is modulated by dominant-negative inactive isoforms (PubMed:17135265, PubMed:17934067). {ECO:0000250\|UniProtKB:Q03267, ECO:0000269\|PubMed:10204490, ECO:0000269\|PubMed:17135265, ECO:0000269\|PubMed:17934067, ECO:0000269\|PubMed:19141594}.	P61769 Main function of 5'-partner protein: FUNCTION: Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. Exogenously applied M.tuberculosis EsxA or EsxA-EsxB (or EsxA expressed in host) binds B2M and decreases its export to the cell surface (total protein levels do not change), probably leading to defects in class I antigen presentation (PubMed:25356553). {ECO:0000269\|PubMed:25356553}.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000492782, ENST00000331340, ENST00000343574, ENST00000346667, ENST00000349824, ENST00000357364, ENST00000359197, ENST00000413698, ENST00000438033, ENST00000439701, ENST00000440768,	ENST00000544417, ENST00000558401, ENST00000559916, ENST00000559220,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	8 X 7 X 6=336	64 X 31 X 17=33728
	# samples	8	71
	** MAII score	log2(8/336*10)=-2.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(71/33728*10)=-5.56998393724517 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Fusion gene context	PubMed: IKZF1 [Title/Abstract] AND B2M [Title/Abstract] AND fusion [Title/Abstract]
Fusion neoantigen context	PubMed: IKZF1 [Title/Abstract] AND B2M [Title/Abstract] AND neoantigen [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	IKZF1(50367356)-B2M(45007620), # samples:1
Anticipated loss of major functional domain due to fusion event.	IKZF1-B2M seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. IKZF1-B2M seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. IKZF1-B2M seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. IKZF1-B2M seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. IKZF1-B2M seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF. IKZF1-B2M seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF. IKZF1-B2M seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. IKZF1-B2M seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF. IKZF1-B2M seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF. IKZF1-B2M seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	B2M	GO:0002726	positive regulation of T cell cytokine production	24643698
Tgene	B2M	GO:0007611	learning or memory	26147761
Tgene	B2M	GO:0050680	negative regulation of epithelial cell proliferation	28213472
Tgene	B2M	GO:0050768	negative regulation of neurogenesis	26147761
Tgene	B2M	GO:0090647	modulation of age-related behavioral decline	26147761
Tgene	B2M	GO:1900121	negative regulation of receptor binding	9465039
Tgene	B2M	GO:1990000	amyloid fibril formation	28468825
Tgene	B2M	GO:2000774	positive regulation of cellular senescence	28213472
Tgene	B2M	GO:2000978	negative regulation of forebrain neuron differentiation	26147761

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:50367356/chr15:45007620)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Retention analysis results of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features, are available here.

Fusion gene breakpoints across IKZF1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across B2M (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Amino Acid Sequences

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000440768	IKZF1	chr7	50367356	+	ENST00000558401	B2M	chr15	45007620	+	1893	315	53	607	184
ENST00000440768	IKZF1	chr7	50367356	+	ENST00000559916	B2M	chr15	45007620	+	1295	315	53	607	184
ENST00000359197	IKZF1	chr7	50367356	+	ENST00000558401	B2M	chr15	45007620	+	1893	315	53	607	184
ENST00000359197	IKZF1	chr7	50367356	+	ENST00000559916	B2M	chr15	45007620	+	1295	315	53	607	184
ENST00000343574	IKZF1	chr7	50367356	+	ENST00000558401	B2M	chr15	45007620	+	1893	315	53	607	184
ENST00000343574	IKZF1	chr7	50367356	+	ENST00000559916	B2M	chr15	45007620	+	1295	315	53	607	184
ENST00000331340	IKZF1	chr7	50367356	+	ENST00000558401	B2M	chr15	45007620	+	1893	315	53	607	184
ENST00000331340	IKZF1	chr7	50367356	+	ENST00000559916	B2M	chr15	45007620	+	1295	315	53	607	184
ENST00000349824	IKZF1	chr7	50367356	+	ENST00000558401	B2M	chr15	45007620	+	1893	315	53	607	184
ENST00000349824	IKZF1	chr7	50367356	+	ENST00000559916	B2M	chr15	45007620	+	1295	315	53	607	184
ENST00000357364	IKZF1	chr7	50367356	+	ENST00000558401	B2M	chr15	45007620	+	1893	315	53	607	184
ENST00000357364	IKZF1	chr7	50367356	+	ENST00000559916	B2M	chr15	45007620	+	1295	315	53	607	184
ENST00000346667	IKZF1	chr7	50367356	+	ENST00000558401	B2M	chr15	45007620	+	1893	315	53	607	184
ENST00000346667	IKZF1	chr7	50367356	+	ENST00000559916	B2M	chr15	45007620	+	1295	315	53	607	184
ENST00000438033	IKZF1	chr7	50367356	+	ENST00000558401	B2M	chr15	45007620	+	1938	360	128	652	174
ENST00000438033	IKZF1	chr7	50367356	+	ENST00000559916	B2M	chr15	45007620	+	1340	360	128	652	174
ENST00000439701	IKZF1	chr7	50367356	+	ENST00000558401	B2M	chr15	45007620	+	1937	359	127	651	174
ENST00000439701	IKZF1	chr7	50367356	+	ENST00000559916	B2M	chr15	45007620	+	1339	359	127	651	174
ENST00000413698	IKZF1	chr7	50367356	+	ENST00000558401	B2M	chr15	45007620	+	1947	369	29	661	210
ENST00000413698	IKZF1	chr7	50367356	+	ENST00000559916	B2M	chr15	45007620	+	1349	369	29	661	210

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000440768	ENST00000558401	IKZF1	chr7	50367356	+	B2M	chr15	45007620	+	0.001503023	0.998497
ENST00000440768	ENST00000559916	IKZF1	chr7	50367356	+	B2M	chr15	45007620	+	0.002862587	0.9971374
ENST00000359197	ENST00000558401	IKZF1	chr7	50367356	+	B2M	chr15	45007620	+	0.001503023	0.998497
ENST00000359197	ENST00000559916	IKZF1	chr7	50367356	+	B2M	chr15	45007620	+	0.002862587	0.9971374
ENST00000343574	ENST00000558401	IKZF1	chr7	50367356	+	B2M	chr15	45007620	+	0.001503023	0.998497
ENST00000343574	ENST00000559916	IKZF1	chr7	50367356	+	B2M	chr15	45007620	+	0.002862587	0.9971374
ENST00000331340	ENST00000558401	IKZF1	chr7	50367356	+	B2M	chr15	45007620	+	0.001503023	0.998497
ENST00000331340	ENST00000559916	IKZF1	chr7	50367356	+	B2M	chr15	45007620	+	0.002862587	0.9971374
ENST00000349824	ENST00000558401	IKZF1	chr7	50367356	+	B2M	chr15	45007620	+	0.001503023	0.998497
ENST00000349824	ENST00000559916	IKZF1	chr7	50367356	+	B2M	chr15	45007620	+	0.002862587	0.9971374
ENST00000357364	ENST00000558401	IKZF1	chr7	50367356	+	B2M	chr15	45007620	+	0.001503023	0.998497
ENST00000357364	ENST00000559916	IKZF1	chr7	50367356	+	B2M	chr15	45007620	+	0.002862587	0.9971374
ENST00000346667	ENST00000558401	IKZF1	chr7	50367356	+	B2M	chr15	45007620	+	0.001503023	0.998497
ENST00000346667	ENST00000559916	IKZF1	chr7	50367356	+	B2M	chr15	45007620	+	0.002862587	0.9971374
ENST00000438033	ENST00000558401	IKZF1	chr7	50367356	+	B2M	chr15	45007620	+	0.001693822	0.99830616
ENST00000438033	ENST00000559916	IKZF1	chr7	50367356	+	B2M	chr15	45007620	+	0.002406512	0.99759346
ENST00000439701	ENST00000558401	IKZF1	chr7	50367356	+	B2M	chr15	45007620	+	0.001653154	0.9983468
ENST00000439701	ENST00000559916	IKZF1	chr7	50367356	+	B2M	chr15	45007620	+	0.002530461	0.99746954
ENST00000413698	ENST00000558401	IKZF1	chr7	50367356	+	B2M	chr15	45007620	+	0.00190691	0.99809307
ENST00000413698	ENST00000559916	IKZF1	chr7	50367356	+	B2M	chr15	45007620	+	0.003942355	0.9960576

Predicted full-length fusion amino acid sequences. For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among all the predicted ones.

Get the fusion protein sequences from here.

Fusion protein sequence information is available in the fasta format.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

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Fusion Protein Breakpoint Sequences for IKZF1-B2M

+/-13 AA sequence from the breakpoints of the fusion protein sequences.

Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	Length(fusion protein)	BP in fusion protein	Peptide
IKZF1	chr7	50367356	B2M	chr15	45007620	315	87	SGGQQSSKSDRVVGTPKIQVYSRHPA
IKZF1	chr7	50367356	B2M	chr15	45007620	359	77	SGGQQSSKSDRVVGTPKIQVYSRHPA
IKZF1	chr7	50367356	B2M	chr15	45007620	360	77	SGGQQSSKSDRVVGTPKIQVYSRHPA
IKZF1	chr7	50367356	B2M	chr15	45007620	369	113	SGGQQSSKSDRVVGTPKIQVYSRHPA

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Potential FusionNeoAntigen Information of IKZF1-B2M in HLA I

Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.

IKZF1-B2M_50367356_45007620.msa

Potential FusionNeoAntigen Information
* We used NetMHCpan v4.1 (%rank<0.5) and deepHLApan v1.1 (immunogenic score>0.5)

Fusion gene	Hchr	Hbp	Tgene	Tchr	Tbp	HLA I	FusionNeoAntigen peptide	Binding score	Immunogenic score	Neoantigen start (at BP 13)	Neoantigen end (at BP 13)
IKZF1-B2M	chr7	50367356	chr15	45007620	315	HLA-B14:01	DRVVGTPKI	0.9972	0.6315	9	18
IKZF1-B2M	chr7	50367356	chr15	45007620	315	HLA-B14:02	DRVVGTPKI	0.9972	0.6315	9	18
IKZF1-B2M	chr7	50367356	chr15	45007620	315	HLA-B15:25	VGTPKIQVY	0.9953	0.8543	12	21
IKZF1-B2M	chr7	50367356	chr15	45007620	315	HLA-B39:06	DRVVGTPKI	0.9747	0.7305	9	18
IKZF1-B2M	chr7	50367356	chr15	45007620	315	HLA-B15:03	VGTPKIQVY	0.9365	0.6108	12	21
IKZF1-B2M	chr7	50367356	chr15	45007620	315	HLA-B58:02	VGTPKIQVY	0.9206	0.7842	12	21
IKZF1-B2M	chr7	50367356	chr15	45007620	315	HLA-B15:01	VVGTPKIQVY	0.9989	0.7672	11	21
IKZF1-B2M	chr7	50367356	chr15	45007620	315	HLA-A30:08	KSDRVVGTPK	0.9884	0.7939	7	17
IKZF1-B2M	chr7	50367356	chr15	45007620	315	HLA-B15:01	RVVGTPKIQVY	0.9999	0.7865	10	21
IKZF1-B2M	chr7	50367356	chr15	45007620	315	HLA-B15:25	RVVGTPKIQVY	0.9997	0.8447	10	21
IKZF1-B2M	chr7	50367356	chr15	45007620	315	HLA-B15:17	RVVGTPKIQVY	0.9994	0.7999	10	21
IKZF1-B2M	chr7	50367356	chr15	45007620	315	HLA-C15:06	VVGTPKIQV	0.9932	0.7828	11	20
IKZF1-B2M	chr7	50367356	chr15	45007620	315	HLA-B15:05	VGTPKIQVY	0.9676	0.752	12	21
IKZF1-B2M	chr7	50367356	chr15	45007620	315	HLA-B39:12	DRVVGTPKI	0.9584	0.7266	9	18
IKZF1-B2M	chr7	50367356	chr15	45007620	315	HLA-B73:01	DRVVGTPKI	0.9138	0.5187	9	18
IKZF1-B2M	chr7	50367356	chr15	45007620	315	HLA-C15:04	VGTPKIQVY	0.9039	0.7828	12	21
IKZF1-B2M	chr7	50367356	chr15	45007620	315	HLA-C07:67	VGTPKIQVY	0.8815	0.8655	12	21
IKZF1-B2M	chr7	50367356	chr15	45007620	315	HLA-C07:80	VGTPKIQVY	0.8815	0.8655	12	21
IKZF1-B2M	chr7	50367356	chr15	45007620	315	HLA-C07:10	VGTPKIQVY	0.8775	0.8933	12	21
IKZF1-B2M	chr7	50367356	chr15	45007620	315	HLA-C12:16	VGTPKIQVY	0.8355	0.9045	12	21
IKZF1-B2M	chr7	50367356	chr15	45007620	315	HLA-C07:27	VGTPKIQVY	0.7663	0.9225	12	21
IKZF1-B2M	chr7	50367356	chr15	45007620	315	HLA-C03:14	VGTPKIQVY	0.482	0.9475	12	21
IKZF1-B2M	chr7	50367356	chr15	45007620	315	HLA-C06:03	VGTPKIQVY	0.4148	0.9772	12	21
IKZF1-B2M	chr7	50367356	chr15	45007620	315	HLA-C12:04	VGTPKIQVY	0.3994	0.9806	12	21
IKZF1-B2M	chr7	50367356	chr15	45007620	315	HLA-C12:12	VGTPKIQVY	0.3622	0.8273	12	21
IKZF1-B2M	chr7	50367356	chr15	45007620	315	HLA-C15:04	RVVGTPKIQVY	0.9985	0.8701	10	21
IKZF1-B2M	chr7	50367356	chr15	45007620	315	HLA-B15:05	RVVGTPKIQVY	0.9964	0.7645	10	21
IKZF1-B2M	chr7	50367356	chr15	45007620	315	HLA-C15:02	VVGTPKIQV	0.9974	0.7846	11	20
IKZF1-B2M	chr7	50367356	chr15	45007620	315	HLA-C15:05	VVGTPKIQV	0.9964	0.8086	11	20
IKZF1-B2M	chr7	50367356	chr15	45007620	315	HLA-B15:39	VGTPKIQVY	0.9935	0.7248	12	21
IKZF1-B2M	chr7	50367356	chr15	45007620	315	HLA-B35:11	VGTPKIQVY	0.9868	0.8186	12	21
IKZF1-B2M	chr7	50367356	chr15	45007620	315	HLA-B39:31	DRVVGTPKI	0.971	0.7254	9	18
IKZF1-B2M	chr7	50367356	chr15	45007620	315	HLA-B35:28	VGTPKIQVY	0.9547	0.8388	12	21
IKZF1-B2M	chr7	50367356	chr15	45007620	315	HLA-B58:06	VGTPKIQVY	0.954	0.6847	12	21
IKZF1-B2M	chr7	50367356	chr15	45007620	315	HLA-C03:02	VGTPKIQVY	0.953	0.9436	12	21
IKZF1-B2M	chr7	50367356	chr15	45007620	315	HLA-B15:27	VGTPKIQVY	0.9412	0.7672	12	21
IKZF1-B2M	chr7	50367356	chr15	45007620	315	HLA-B15:135	VGTPKIQVY	0.9355	0.797	12	21
IKZF1-B2M	chr7	50367356	chr15	45007620	315	HLA-B15:50	VGTPKIQVY	0.9348	0.7122	12	21
IKZF1-B2M	chr7	50367356	chr15	45007620	315	HLA-B15:12	VGTPKIQVY	0.9285	0.7652	12	21
IKZF1-B2M	chr7	50367356	chr15	45007620	315	HLA-B15:11	VGTPKIQVY	0.9153	0.7002	12	21
IKZF1-B2M	chr7	50367356	chr15	45007620	315	HLA-B15:08	VGTPKIQVY	0.9108	0.6921	12	21
IKZF1-B2M	chr7	50367356	chr15	45007620	315	HLA-C15:09	VGTPKIQVY	0.9039	0.7828	12	21
IKZF1-B2M	chr7	50367356	chr15	45007620	315	HLA-C07:02	VGTPKIQVY	0.8815	0.8655	12	21
IKZF1-B2M	chr7	50367356	chr15	45007620	315	HLA-B35:43	VGTPKIQVY	0.8734	0.6953	12	21
IKZF1-B2M	chr7	50367356	chr15	45007620	315	HLA-C07:17	VGTPKIQVY	0.8688	0.9211	12	21
IKZF1-B2M	chr7	50367356	chr15	45007620	315	HLA-B15:35	VGTPKIQVY	0.8082	0.7616	12	21
IKZF1-B2M	chr7	50367356	chr15	45007620	315	HLA-C12:02	VGTPKIQVY	0.5957	0.919	12	21
IKZF1-B2M	chr7	50367356	chr15	45007620	315	HLA-C16:04	VGTPKIQVY	0.5052	0.9521	12	21
IKZF1-B2M	chr7	50367356	chr15	45007620	315	HLA-C06:06	VGTPKIQVY	0.4514	0.9841	12	21
IKZF1-B2M	chr7	50367356	chr15	45007620	315	HLA-C12:03	VGTPKIQVY	0.4314	0.9363	12	21
IKZF1-B2M	chr7	50367356	chr15	45007620	315	HLA-C16:01	VGTPKIQVY	0.3744	0.9662	12	21
IKZF1-B2M	chr7	50367356	chr15	45007620	315	HLA-C16:02	VGTPKIQVY	0.2937	0.982	12	21
IKZF1-B2M	chr7	50367356	chr15	45007620	315	HLA-C02:10	VGTPKIQVY	0.1774	0.9545	12	21
IKZF1-B2M	chr7	50367356	chr15	45007620	315	HLA-C02:02	VGTPKIQVY	0.1774	0.9545	12	21
IKZF1-B2M	chr7	50367356	chr15	45007620	315	HLA-B15:33	VVGTPKIQVY	0.9989	0.7672	11	21
IKZF1-B2M	chr7	50367356	chr15	45007620	315	HLA-B15:125	VVGTPKIQVY	0.9989	0.7672	11	21
IKZF1-B2M	chr7	50367356	chr15	45007620	315	HLA-B15:34	VVGTPKIQVY	0.9989	0.7672	11	21
IKZF1-B2M	chr7	50367356	chr15	45007620	315	HLA-B15:27	VVGTPKIQVY	0.9988	0.7786	11	21
IKZF1-B2M	chr7	50367356	chr15	45007620	315	HLA-B15:135	VVGTPKIQVY	0.9987	0.8129	11	21
IKZF1-B2M	chr7	50367356	chr15	45007620	315	HLA-B15:35	VVGTPKIQVY	0.9982	0.7708	11	21
IKZF1-B2M	chr7	50367356	chr15	45007620	315	HLA-B15:12	VVGTPKIQVY	0.9943	0.8197	11	21
IKZF1-B2M	chr7	50367356	chr15	45007620	315	HLA-A30:01	KSDRVVGTPK	0.9894	0.916	7	17
IKZF1-B2M	chr7	50367356	chr15	45007620	315	HLA-B15:125	RVVGTPKIQVY	0.9999	0.7865	10	21
IKZF1-B2M	chr7	50367356	chr15	45007620	315	HLA-B15:34	RVVGTPKIQVY	0.9999	0.7865	10	21
IKZF1-B2M	chr7	50367356	chr15	45007620	315	HLA-B15:24	RVVGTPKIQVY	0.9999	0.7546	10	21
IKZF1-B2M	chr7	50367356	chr15	45007620	315	HLA-B15:35	RVVGTPKIQVY	0.9999	0.7898	10	21
IKZF1-B2M	chr7	50367356	chr15	45007620	315	HLA-B15:50	RVVGTPKIQVY	0.9999	0.7595	10	21
IKZF1-B2M	chr7	50367356	chr15	45007620	315	HLA-B15:135	RVVGTPKIQVY	0.9999	0.8026	10	21
IKZF1-B2M	chr7	50367356	chr15	45007620	315	HLA-B15:12	RVVGTPKIQVY	0.9999	0.7197	10	21
IKZF1-B2M	chr7	50367356	chr15	45007620	315	HLA-B15:27	RVVGTPKIQVY	0.9999	0.8149	10	21
IKZF1-B2M	chr7	50367356	chr15	45007620	315	HLA-B15:33	RVVGTPKIQVY	0.9999	0.7865	10	21
IKZF1-B2M	chr7	50367356	chr15	45007620	315	HLA-B15:39	RVVGTPKIQVY	0.9998	0.7112	10	21
IKZF1-B2M	chr7	50367356	chr15	45007620	315	HLA-B58:06	RVVGTPKIQVY	0.999	0.7161	10	21
IKZF1-B2M	chr7	50367356	chr15	45007620	315	HLA-C15:09	RVVGTPKIQVY	0.9985	0.8701	10	21
IKZF1-B2M	chr7	50367356	chr15	45007620	315	HLA-B15:20	RVVGTPKIQVY	0.9968	0.8366	10	21
IKZF1-B2M	chr7	50367356	chr15	45007620	315	HLA-A32:01	RVVGTPKIQVY	0.9935	0.8212	10	21
IKZF1-B2M	chr7	50367356	chr15	45007620	315	HLA-B35:28	RVVGTPKIQVY	0.9928	0.8427	10	21

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Potential FusionNeoAntigen Information of IKZF1-B2M in HLA II

IKZF1-B2M_50367356_45007620.msa

Potential FusionNeoAntigen Information
* We used NetMHCIIpan v4.1 (%rank<0.5).

Fusion gene	Hchr	Hbp	Tgene	Tchr	Tbp	HLA II	FusionNeoAntigen peptide	Neoantigen start (at BP 13)	Neoantigen end (at BP 13)
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-0324	SDRVVGTPKIQVYSR	8	23
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1102	VVGTPKIQVYSRHPA	11	26
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1103	VVGTPKIQVYSRHPA	11	26
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1113	SDRVVGTPKIQVYSR	8	23
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1113	KSDRVVGTPKIQVYS	7	22
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1116	VVGTPKIQVYSRHPA	11	26
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1117	SDRVVGTPKIQVYSR	8	23
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1117	KSDRVVGTPKIQVYS	7	22
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1117	SKSDRVVGTPKIQVY	6	21
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1117	DRVVGTPKIQVYSRH	9	24
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1121	VVGTPKIQVYSRHPA	11	26
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1134	SDRVVGTPKIQVYSR	8	23
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1136	VVGTPKIQVYSRHPA	11	26
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1148	VVGTPKIQVYSRHPA	11	26
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1148	SDRVVGTPKIQVYSR	8	23
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1152	SDRVVGTPKIQVYSR	8	23
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1152	KSDRVVGTPKIQVYS	7	22
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1152	SKSDRVVGTPKIQVY	6	21
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1152	DRVVGTPKIQVYSRH	9	24
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1155	VVGTPKIQVYSRHPA	11	26
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1157	SDRVVGTPKIQVYSR	8	23
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1159	VVGTPKIQVYSRHPA	11	26
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1163	VVGTPKIQVYSRHPA	11	26
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1165	VVGTPKIQVYSRHPA	11	26
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1170	VVGTPKIQVYSRHPA	11	26
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1176	VVGTPKIQVYSRHPA	11	26
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1185	VVGTPKIQVYSRHPA	11	26
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1189	SDRVVGTPKIQVYSR	8	23
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1189	KSDRVVGTPKIQVYS	7	22
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1301	VVGTPKIQVYSRHPA	11	26
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1304	VVGTPKIQVYSRHPA	11	26
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1304	SDRVVGTPKIQVYSR	8	23
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1308	VVGTPKIQVYSRHPA	11	26
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1308	SDRVVGTPKIQVYSR	8	23
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1309	VVGTPKIQVYSRHPA	11	26
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1309	SDRVVGTPKIQVYSR	8	23
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-13100	SDRVVGTPKIQVYSR	8	23
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1315	VVGTPKIQVYSRHPA	11	26
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1317	VVGTPKIQVYSRHPA	11	26
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1319	VVGTPKIQVYSRHPA	11	26
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1320	VVGTPKIQVYSRHPA	11	26
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1322	VVGTPKIQVYSRHPA	11	26
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1324	VVGTPKIQVYSRHPA	11	26
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1327	VVGTPKIQVYSRHPA	11	26
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1331	SDRVVGTPKIQVYSR	8	23
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1331	KSDRVVGTPKIQVYS	7	22
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1332	VVGTPKIQVYSRHPA	11	26
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1332	SDRVVGTPKIQVYSR	8	23
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1335	VVGTPKIQVYSRHPA	11	26
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1343	SDRVVGTPKIQVYSR	8	23
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1343	VVGTPKIQVYSRHPA	11	26
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1343	KSDRVVGTPKIQVYS	7	22
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1344	SDRVVGTPKIQVYSR	8	23
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1346	SDRVVGTPKIQVYSR	8	23
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1348	VVGTPKIQVYSRHPA	11	26
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1348	SDRVVGTPKIQVYSR	8	23
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1351	VVGTPKIQVYSRHPA	11	26
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1352	VVGTPKIQVYSRHPA	11	26
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1353	VVGTPKIQVYSRHPA	11	26
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1354	SDRVVGTPKIQVYSR	8	23
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1354	VVGTPKIQVYSRHPA	11	26
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1354	KSDRVVGTPKIQVYS	7	22
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1357	VVGTPKIQVYSRHPA	11	26
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1359	VVGTPKIQVYSRHPA	11	26
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1361	VVGTPKIQVYSRHPA	11	26
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1364	VVGTPKIQVYSRHPA	11	26
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1368	VVGTPKIQVYSRHPA	11	26
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1369	VVGTPKIQVYSRHPA	11	26
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1370	VVGTPKIQVYSRHPA	11	26
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1370	SDRVVGTPKIQVYSR	8	23
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1372	VVGTPKIQVYSRHPA	11	26
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1372	SDRVVGTPKIQVYSR	8	23
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1375	VVGTPKIQVYSRHPA	11	26
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1376	SDRVVGTPKIQVYSR	8	23
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1376	VVGTPKIQVYSRHPA	11	26
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1376	KSDRVVGTPKIQVYS	7	22
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1377	SDRVVGTPKIQVYSR	8	23
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1377	KSDRVVGTPKIQVYS	7	22
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1378	VVGTPKIQVYSRHPA	11	26
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1379	VVGTPKIQVYSRHPA	11	26
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1380	VVGTPKIQVYSRHPA	11	26
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1381	SDRVVGTPKIQVYSR	8	23
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1383	VVGTPKIQVYSRHPA	11	26
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1384	VVGTPKIQVYSRHPA	11	26
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1384	SDRVVGTPKIQVYSR	8	23
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1387	VVGTPKIQVYSRHPA	11	26
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1391	VVGTPKIQVYSRHPA	11	26
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1392	VVGTPKIQVYSRHPA	11	26
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1393	VVGTPKIQVYSRHPA	11	26
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1393	SDRVVGTPKIQVYSR	8	23
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1394	SDRVVGTPKIQVYSR	8	23
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1398	VVGTPKIQVYSRHPA	11	26
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1401	SDRVVGTPKIQVYSR	8	23
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1401	KSDRVVGTPKIQVYS	7	22
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1401	SKSDRVVGTPKIQVY	6	21
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1401	DRVVGTPKIQVYSRH	9	24
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1404	SDRVVGTPKIQVYSR	8	23
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1404	KSDRVVGTPKIQVYS	7	22
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1404	SKSDRVVGTPKIQVY	6	21
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1404	DRVVGTPKIQVYSRH	9	24
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1405	SDRVVGTPKIQVYSR	8	23
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1405	KSDRVVGTPKIQVYS	7	22
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1405	SKSDRVVGTPKIQVY	6	21
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1405	DRVVGTPKIQVYSRH	9	24
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1406	SDRVVGTPKIQVYSR	8	23
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1407	SDRVVGTPKIQVYSR	8	23
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1407	KSDRVVGTPKIQVYS	7	22
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1407	SKSDRVVGTPKIQVY	6	21
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1407	DRVVGTPKIQVYSRH	9	24
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1408	SDRVVGTPKIQVYSR	8	23
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1408	KSDRVVGTPKIQVYS	7	22
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1408	SKSDRVVGTPKIQVY	6	21
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1408	DRVVGTPKIQVYSRH	9	24
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1411	SDRVVGTPKIQVYSR	8	23
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1411	KSDRVVGTPKIQVYS	7	22
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1411	SKSDRVVGTPKIQVY	6	21
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1411	DRVVGTPKIQVYSRH	9	24
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1412	SDRVVGTPKIQVYSR	8	23
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1414	SDRVVGTPKIQVYSR	8	23
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1414	KSDRVVGTPKIQVYS	7	22
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1416	SDRVVGTPKIQVYSR	8	23
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1416	VVGTPKIQVYSRHPA	11	26
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1416	KSDRVVGTPKIQVYS	7	22
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1417	SDRVVGTPKIQVYSR	8	23
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1418	SDRVVGTPKIQVYSR	8	23
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1418	KSDRVVGTPKIQVYS	7	22
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1418	DRVVGTPKIQVYSRH	9	24
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1418	SKSDRVVGTPKIQVY	6	21
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1420	SDRVVGTPKIQVYSR	8	23
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1421	SDRVVGTPKIQVYSR	8	23
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1423	SDRVVGTPKIQVYSR	8	23
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1423	KSDRVVGTPKIQVYS	7	22
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1423	SKSDRVVGTPKIQVY	6	21
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1423	DRVVGTPKIQVYSRH	9	24
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1426	SDRVVGTPKIQVYSR	8	23
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1426	KSDRVVGTPKIQVYS	7	22
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1426	SKSDRVVGTPKIQVY	6	21
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1426	DRVVGTPKIQVYSRH	9	24
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1428	SDRVVGTPKIQVYSR	8	23
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1428	KSDRVVGTPKIQVYS	7	22
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1428	SKSDRVVGTPKIQVY	6	21
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1428	DRVVGTPKIQVYSRH	9	24
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1429	SDRVVGTPKIQVYSR	8	23
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1429	KSDRVVGTPKIQVYS	7	22
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1431	SDRVVGTPKIQVYSR	8	23
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1431	KSDRVVGTPKIQVYS	7	22
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1431	SKSDRVVGTPKIQVY	6	21
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1432	SDRVVGTPKIQVYSR	8	23
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1432	KSDRVVGTPKIQVYS	7	22
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1432	SKSDRVVGTPKIQVY	6	21
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1432	DRVVGTPKIQVYSRH	9	24
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1433	SDRVVGTPKIQVYSR	8	23
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1433	KSDRVVGTPKIQVYS	7	22
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1434	SDRVVGTPKIQVYSR	8	23
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1434	KSDRVVGTPKIQVYS	7	22
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1435	SDRVVGTPKIQVYSR	8	23
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1435	KSDRVVGTPKIQVYS	7	22
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1435	SKSDRVVGTPKIQVY	6	21
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1435	DRVVGTPKIQVYSRH	9	24
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1436	SDRVVGTPKIQVYSR	8	23
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1436	KSDRVVGTPKIQVYS	7	22
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1437	SDRVVGTPKIQVYSR	8	23
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1437	VVGTPKIQVYSRHPA	11	26
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1438	SDRVVGTPKIQVYSR	8	23
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1438	KSDRVVGTPKIQVYS	7	22
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1438	SKSDRVVGTPKIQVY	6	21
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1438	DRVVGTPKIQVYSRH	9	24
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1439	SDRVVGTPKIQVYSR	8	23
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1439	KSDRVVGTPKIQVYS	7	22
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1439	SKSDRVVGTPKIQVY	6	21
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1439	DRVVGTPKIQVYSRH	9	24
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1442	SDRVVGTPKIQVYSR	8	23
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1442	KSDRVVGTPKIQVYS	7	22
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1443	SDRVVGTPKIQVYSR	8	23
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1443	KSDRVVGTPKIQVYS	7	22
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1443	SKSDRVVGTPKIQVY	6	21
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1443	DRVVGTPKIQVYSRH	9	24
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1444	SDRVVGTPKIQVYSR	8	23
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1444	KSDRVVGTPKIQVYS	7	22
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1445	SDRVVGTPKIQVYSR	8	23
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1445	KSDRVVGTPKIQVYS	7	22
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1445	SKSDRVVGTPKIQVY	6	21
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1445	DRVVGTPKIQVYSRH	9	24
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1448	SDRVVGTPKIQVYSR	8	23
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1449	SDRVVGTPKIQVYSR	8	23
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1449	KSDRVVGTPKIQVYS	7	22
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1450	SDRVVGTPKIQVYSR	8	23
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1450	KSDRVVGTPKIQVYS	7	22
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1450	SKSDRVVGTPKIQVY	6	21
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1450	DRVVGTPKIQVYSRH	9	24
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1451	SDRVVGTPKIQVYSR	8	23
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1452	SDRVVGTPKIQVYSR	8	23
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1454	SDRVVGTPKIQVYSR	8	23
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1454	KSDRVVGTPKIQVYS	7	22
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1454	SKSDRVVGTPKIQVY	6	21
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1454	DRVVGTPKIQVYSRH	9	24
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1455	SDRVVGTPKIQVYSR	8	23
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1455	KSDRVVGTPKIQVYS	7	22
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1455	SKSDRVVGTPKIQVY	6	21
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1455	DRVVGTPKIQVYSRH	9	24
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1456	SDRVVGTPKIQVYSR	8	23
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1456	KSDRVVGTPKIQVYS	7	22
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1456	SKSDRVVGTPKIQVY	6	21
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1456	DRVVGTPKIQVYSRH	9	24
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1458	SDRVVGTPKIQVYSR	8	23
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1458	KSDRVVGTPKIQVYS	7	22
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1458	SKSDRVVGTPKIQVY	6	21
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1458	DRVVGTPKIQVYSRH	9	24
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1459	SDRVVGTPKIQVYSR	8	23
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1459	KSDRVVGTPKIQVYS	7	22
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1459	SKSDRVVGTPKIQVY	6	21
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1459	DRVVGTPKIQVYSRH	9	24
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1460	SDRVVGTPKIQVYSR	8	23
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1460	KSDRVVGTPKIQVYS	7	22
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1460	SKSDRVVGTPKIQVY	6	21
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1460	DRVVGTPKIQVYSRH	9	24
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1461	SDRVVGTPKIQVYSR	8	23
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1461	KSDRVVGTPKIQVYS	7	22
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1461	SKSDRVVGTPKIQVY	6	21
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1461	DRVVGTPKIQVYSRH	9	24
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1462	SDRVVGTPKIQVYSR	8	23
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1462	KSDRVVGTPKIQVYS	7	22
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1462	SKSDRVVGTPKIQVY	6	21
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1462	DRVVGTPKIQVYSRH	9	24
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1464	SDRVVGTPKIQVYSR	8	23
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1464	KSDRVVGTPKIQVYS	7	22
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1464	SKSDRVVGTPKIQVY	6	21
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1464	DRVVGTPKIQVYSRH	9	24
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1465	SDRVVGTPKIQVYSR	8	23
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1465	KSDRVVGTPKIQVYS	7	22
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1468	SDRVVGTPKIQVYSR	8	23
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1468	KSDRVVGTPKIQVYS	7	22
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1468	SKSDRVVGTPKIQVY	6	21
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1470	SDRVVGTPKIQVYSR	8	23
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1470	KSDRVVGTPKIQVYS	7	22
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1470	SKSDRVVGTPKIQVY	6	21
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1470	DRVVGTPKIQVYSRH	9	24
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1470	SSKSDRVVGTPKIQV	5	20
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1471	SDRVVGTPKIQVYSR	8	23
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1471	KSDRVVGTPKIQVYS	7	22
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1471	SKSDRVVGTPKIQVY	6	21
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1471	DRVVGTPKIQVYSRH	9	24
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1472	SDRVVGTPKIQVYSR	8	23
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1472	KSDRVVGTPKIQVYS	7	22
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1472	SKSDRVVGTPKIQVY	6	21
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1472	DRVVGTPKIQVYSRH	9	24
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1473	SDRVVGTPKIQVYSR	8	23
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1473	KSDRVVGTPKIQVYS	7	22
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1473	SKSDRVVGTPKIQVY	6	21
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1474	SDRVVGTPKIQVYSR	8	23
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1474	KSDRVVGTPKIQVYS	7	22
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1475	SDRVVGTPKIQVYSR	8	23
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1475	KSDRVVGTPKIQVYS	7	22
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1475	SKSDRVVGTPKIQVY	6	21
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1475	DRVVGTPKIQVYSRH	9	24
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1480	SDRVVGTPKIQVYSR	8	23
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1481	SDRVVGTPKIQVYSR	8	23
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1481	KSDRVVGTPKIQVYS	7	22
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1482	SDRVVGTPKIQVYSR	8	23
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1482	KSDRVVGTPKIQVYS	7	22
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1482	SKSDRVVGTPKIQVY	6	21
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1482	DRVVGTPKIQVYSRH	9	24
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1483	SDRVVGTPKIQVYSR	8	23
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1484	SDRVVGTPKIQVYSR	8	23
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1486	SDRVVGTPKIQVYSR	8	23
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1486	KSDRVVGTPKIQVYS	7	22
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1486	SKSDRVVGTPKIQVY	6	21
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1486	DRVVGTPKIQVYSRH	9	24
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1487	SDRVVGTPKIQVYSR	8	23
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1487	KSDRVVGTPKIQVYS	7	22
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1487	SKSDRVVGTPKIQVY	6	21
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1487	DRVVGTPKIQVYSRH	9	24
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1488	SDRVVGTPKIQVYSR	8	23
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1488	KSDRVVGTPKIQVYS	7	22
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1488	SKSDRVVGTPKIQVY	6	21
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1488	DRVVGTPKIQVYSRH	9	24
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1490	SDRVVGTPKIQVYSR	8	23
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1490	KSDRVVGTPKIQVYS	7	22
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1490	SKSDRVVGTPKIQVY	6	21
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1490	DRVVGTPKIQVYSRH	9	24
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1491	SDRVVGTPKIQVYSR	8	23
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1491	KSDRVVGTPKIQVYS	7	22
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1491	SKSDRVVGTPKIQVY	6	21
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1491	DRVVGTPKIQVYSRH	9	24
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1493	SDRVVGTPKIQVYSR	8	23
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1493	KSDRVVGTPKIQVYS	7	22
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1493	SKSDRVVGTPKIQVY	6	21
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1495	SDRVVGTPKIQVYSR	8	23
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1495	KSDRVVGTPKIQVYS	7	22
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1495	SKSDRVVGTPKIQVY	6	21
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1495	DRVVGTPKIQVYSRH	9	24
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1496	SDRVVGTPKIQVYSR	8	23
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1496	KSDRVVGTPKIQVYS	7	22
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1496	SKSDRVVGTPKIQVY	6	21
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1496	DRVVGTPKIQVYSRH	9	24
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1497	SDRVVGTPKIQVYSR	8	23
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1497	KSDRVVGTPKIQVYS	7	22
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1497	SKSDRVVGTPKIQVY	6	21
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1497	DRVVGTPKIQVYSRH	9	24
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1499	SDRVVGTPKIQVYSR	8	23
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1499	KSDRVVGTPKIQVYS	7	22
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1499	SKSDRVVGTPKIQVY	6	21
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1499	DRVVGTPKIQVYSRH	9	24
IKZF1-B2M	chr7	50367356	chr15	45007620	315	DRB1-1499	SSKSDRVVGTPKIQV	5	20

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Fusion breakpoint peptide structures of IKZF1-B2M

3D structures of the fusion breakpoint peptide of 14AA sequence that have potential fusion neoantigens
* The minimum length of the amino acid sequence in RoseTTAFold is 14AA. Here, we predicted the 14AA fusion protein breakpoint sequence not the fusion neoantigen peptide, which is shorter than 14 AA.

File name	BPseq	Hgene	Tgene	Hchr	Hbp	Tchr	Tbp	AAlen
8710	SKSDRVVGTPKIQV	IKZF1	B2M	chr7	50367356	chr15	45007620	315

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Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D of IKZF1-B2M

Virtual screening between 25 HLAs (from PDB) and FusionNeoAntigens
* We used Glide to predict the interaction between HLAs and neoantigens.

HLA allele	PDB ID	File name	BPseq	Docking score	Glide score
HLA-B14:02	3BVN	8710	SKSDRVVGTPKIQV	-7.15543	-7.26883
HLA-B14:02	3BVN	8710	SKSDRVVGTPKIQV	-4.77435	-5.80965
HLA-B52:01	3W39	8710	SKSDRVVGTPKIQV	-6.80875	-6.92215
HLA-B52:01	3W39	8710	SKSDRVVGTPKIQV	-4.20386	-5.23916
HLA-A11:01	4UQ2	8710	SKSDRVVGTPKIQV	-7.5194	-8.5547
HLA-A11:01	4UQ2	8710	SKSDRVVGTPKIQV	-6.9601	-7.0735
HLA-A24:02	5HGA	8710	SKSDRVVGTPKIQV	-7.52403	-7.63743
HLA-A24:02	5HGA	8710	SKSDRVVGTPKIQV	-5.82433	-6.85963
HLA-B27:05	6PYJ	8710	SKSDRVVGTPKIQV	-3.28285	-4.31815
HLA-B44:05	3DX8	8710	SKSDRVVGTPKIQV	-5.91172	-6.94702
HLA-B44:05	3DX8	8710	SKSDRVVGTPKIQV	-4.24346	-4.35686

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Vaccine Design for the FusionNeoAntigens of IKZF1-B2M

mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-Is.

Fusion gene	Hchr	Hbp	Tchr	Tbp	Start in +/-13AA	End in +/-13AA	FusionNeoAntigen peptide sequence	FusionNeoAntigen RNA sequence
IKZF1-B2M	chr7	50367356	chr15	45007620	10	21	RVVGTPKIQVY	GAGTCGTGGGTACTCCAAAGATTCAGGTTTACT
IKZF1-B2M	chr7	50367356	chr15	45007620	11	20	VVGTPKIQV	TCGTGGGTACTCCAAAGATTCAGGTTT
IKZF1-B2M	chr7	50367356	chr15	45007620	11	21	VVGTPKIQVY	TCGTGGGTACTCCAAAGATTCAGGTTTACT
IKZF1-B2M	chr7	50367356	chr15	45007620	12	21	VGTPKIQVY	TGGGTACTCCAAAGATTCAGGTTTACT
IKZF1-B2M	chr7	50367356	chr15	45007620	7	17	KSDRVVGTPK	AGAGTGACAGAGTCGTGGGTACTCCAAAGA
IKZF1-B2M	chr7	50367356	chr15	45007620	9	18	DRVVGTPKI	ACAGAGTCGTGGGTACTCCAAAGATTC

mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-IIs.

Fusion gene	Hchr	Hbp	Tchr	Tbp	Start in +/-13AA	End in +/-13AA	FusionNeoAntigen peptide	FusionNEoAntigen RNA sequence
IKZF1-B2M	chr7	50367356	chr15	45007620	11	26	VVGTPKIQVYSRHPA	TCGTGGGTACTCCAAAGATTCAGGTTTACTCACGTCATCCAGCAG
IKZF1-B2M	chr7	50367356	chr15	45007620	5	20	SSKSDRVVGTPKIQV	GCTCCAAGAGTGACAGAGTCGTGGGTACTCCAAAGATTCAGGTTT
IKZF1-B2M	chr7	50367356	chr15	45007620	6	21	SKSDRVVGTPKIQVY	CCAAGAGTGACAGAGTCGTGGGTACTCCAAAGATTCAGGTTTACT
IKZF1-B2M	chr7	50367356	chr15	45007620	7	22	KSDRVVGTPKIQVYS	AGAGTGACAGAGTCGTGGGTACTCCAAAGATTCAGGTTTACTCAC
IKZF1-B2M	chr7	50367356	chr15	45007620	8	23	SDRVVGTPKIQVYSR	GTGACAGAGTCGTGGGTACTCCAAAGATTCAGGTTTACTCACGTC
IKZF1-B2M	chr7	50367356	chr15	45007620	9	24	DRVVGTPKIQVYSRH	ACAGAGTCGTGGGTACTCCAAAGATTCAGGTTTACTCACGTCATC

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Information of the samples that have these potential fusion neoantigens of IKZF1-B2M

These samples were reported as having these fusion breakpoints. For individual breakpoints, we checked the open reading frames considering multiple gene isoforms and chose the in-frame fusion genes only. Then, we made fusion protein sequences and predicted the fusion neoantigens. These fusion-positive samples may have these potential fusion neoantigens.

Cancer type	Fusion gene	Hchr	Hbp	Henst	Tchr	Tbp	Tenst	Sample
N/A	IKZF1-B2M	chr7	50367356	ENST00000331340	chr15	45007620	ENST00000558401	AW405039

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Potential target of CAR-T therapy development for IKZF1-B2M

Predicted 3D structure. We used RoseTTAFold.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, to provide the retention of the transmembrane domain, we only show the protein feature retention information of those transmembrane features

* Minus value of BPloci means that the break point is located before the CDS.

- In-frame and retained 'Transmembrane'.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Subcellular localization prediction of the transmembrane domain retained fusion proteins
* We used DeepLoc 1.0. The order of the X-axis of the barplot is as follows: Entry_ID, Localization, Type, Nucleus, Cytoplasm, Extracellular, Mitochondrion, Cell_membrane, Endoplasmic_reticulum, Plastid, Golgi.apparatus, Lysosome.Vacuole, Peroxisome. Y-axis is the output score of DeepLoc. Clicking the image will open a new tab with a large image.

Hgene

Hchr

Hbp

Henst

Tgene

Tchr

Tbp

Tenst

DeepLoc result

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Related Drugs to IKZF1-B2M

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to IKZF1-B2M

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source

	Fusion Gene and Fusion Protein Summary
	Fusion Amino Acid Sequences (multiple BPs and multiple gene isoforms)
	Fusion Protein Breakpoint Sequences - (for the Screening of the FusionNeoAntigens)
	Potential FusionNeoAntigens in HLA I - (netMHCpan v4.1 + deepHLApan v1.1)
	Potential FusionNeoAntigens in HLA II - (netMHCIIpan v4.1)
	Fusion Breakpoint 14 AA Peptide Structure - (RoseTTAFold)
	Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D - (Glide)
	Vaccine Design for the FusionNeoAntigens (RNA/protein sequences)
	Potential target of CAR-T therapy development
	Information on the samples that have these potential fusion neoantigens
	Fusion Protein Targeting Drugs - (Manual Curation)
	Fusion Protein Related diseases - (Manual Curation)