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Fusion Protein:ING5-UTRN

Fusion Gene and Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: ING5-UTRN
	FusionPDB ID: 39749
	FusionGDB2.0 ID: 39749
		Hgene	Tgene
	Gene symbol	ING5	UTRN
	Gene ID	84289	7402
	Gene name	inhibitor of growth family member 5	utrophin
	Synonyms	p28ING5	DMDL\|DRP\|DRP1
	Cytomap	2q37.3	6q24.2
	Type of gene	protein-coding	protein-coding
	Description	inhibitor of growth protein 5	utrophinDRP-1dystrophin-related protein 1
	Modification date	20200329	20200313
	UniProtAcc	Q8WYH8 Main function of 5'-partner protein: FUNCTION: Component of the HBO1 complex, which specifically mediates acetylation of histone H3 at 'Lys-14' (H3K14ac) and, to a lower extent, acetylation of histone H4 (PubMed:24065767). Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity (PubMed:16387653). Through chromatin acetylation it may regulate DNA replication and may function as a transcriptional coactivator (PubMed:12750254, PubMed:16387653). Inhibits cell growth, induces a delay in S-phase progression and enhances Fas-induced apoptosis in an INCA1-dependent manner (PubMed:21750715). {ECO:0000269\|PubMed:12750254, ECO:0000269\|PubMed:16387653, ECO:0000269\|PubMed:21750715, ECO:0000269\|PubMed:24065767}.	.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000482774, ENST00000313552, ENST00000406941,	ENST00000367526, ENST00000367545, ENST00000480333,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	2 X 2 X 2=8	41 X 16 X 12=7872
	# samples	2	42
	** MAII score	log2(2/8*10)=1.32192809488736	log2(42/7872*10)=-4.22826898767312 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Fusion gene context	PubMed: ING5 [Title/Abstract] AND UTRN [Title/Abstract] AND fusion [Title/Abstract]
Fusion neoantigen context	PubMed: ING5 [Title/Abstract] AND UTRN [Title/Abstract] AND neoantigen [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	ING5(242651486)-UTRN(145148484), # samples:1
Anticipated loss of major functional domain due to fusion event.	ING5-UTRN seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ING5-UTRN seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	ING5	GO:0006260	DNA replication	16387653
Hgene	ING5	GO:0006473	protein acetylation	12750254
Hgene	ING5	GO:0008285	negative regulation of cell proliferation	12750254
Hgene	ING5	GO:0043966	histone H3 acetylation	16387653
Hgene	ING5	GO:0045893	positive regulation of transcription, DNA-templated	16387653
Hgene	ING5	GO:0045926	negative regulation of growth	12750254

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:242651486/chr6:145148484)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Retention analysis results of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features, are available here.

Fusion gene breakpoints across ING5 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across UTRN (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Amino Acid Sequences

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000313552

ING5

chr2

242651486

ENST00000367545

UTRN

chr6

145148484

3353

508

1315

429

ENST00000313552

ING5

chr2

242651486

ENST00000367526

UTRN

chr6

145148484

1322

508

1315

429

ENST00000406941

ING5

chr2

242651486

ENST00000367545

UTRN

chr6

145148484

3347

502

1309

429

ENST00000406941

ING5

chr2

242651486

ENST00000367526

UTRN

chr6

145148484

1316

502

1309

429

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000313552	ENST00000367545	ING5	chr2	242651486	+	UTRN	chr6	145148484	+	0.000469572	0.99953043
ENST00000313552	ENST00000367526	ING5	chr2	242651486	+	UTRN	chr6	145148484	+	0.004552317	0.9954477
ENST00000406941	ENST00000367545	ING5	chr2	242651486	+	UTRN	chr6	145148484	+	0.000469012	0.99953103
ENST00000406941	ENST00000367526	ING5	chr2	242651486	+	UTRN	chr6	145148484	+	0.004197627	0.99580234

Predicted full-length fusion amino acid sequences. For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among all the predicted ones.

Get the fusion protein sequences from here.

Fusion protein sequence information is available in the fasta format.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

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Fusion Protein Breakpoint Sequences for ING5-UTRN

+/-13 AA sequence from the breakpoints of the fusion protein sequences.

Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	Length(fusion protein)	BP in fusion protein	Peptide
ING5	chr2	242651486	UTRN	chr6	145148484	502	161	EEDTPKKKKHKGGPITLISMWPEHYD
ING5	chr2	242651486	UTRN	chr6	145148484	508	161	EEDTPKKKKHKGGPITLISMWPEHYD

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Potential FusionNeoAntigen Information of ING5-UTRN in HLA I

Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.

ING5-UTRN_242651486_145148484.msa

Potential FusionNeoAntigen Information
* We used NetMHCpan v4.1 (%rank<0.5) and deepHLApan v1.1 (immunogenic score>0.5)

Fusion gene	Hchr	Hbp	Tgene	Tchr	Tbp	HLA I	FusionNeoAntigen peptide	Binding score	Immunogenic score	Neoantigen start (at BP 13)	Neoantigen end (at BP 13)
ING5-UTRN	chr2	242651486	chr6	145148484	508	HLA-B39:24	HKGGPITL	0.9996	0.7828	9	17
ING5-UTRN	chr2	242651486	chr6	145148484	508	HLA-B39:01	HKGGPITL	0.9991	0.9139	9	17
ING5-UTRN	chr2	242651486	chr6	145148484	508	HLA-B15:10	HKGGPITL	0.9511	0.714	9	17
ING5-UTRN	chr2	242651486	chr6	145148484	508	HLA-B15:37	HKGGPITL	0.9387	0.7189	9	17
ING5-UTRN	chr2	242651486	chr6	145148484	508	HLA-B39:24	KHKGGPITL	0.9941	0.7742	8	17
ING5-UTRN	chr2	242651486	chr6	145148484	508	HLA-B39:01	KHKGGPITL	0.9907	0.9042	8	17
ING5-UTRN	chr2	242651486	chr6	145148484	508	HLA-B39:06	KHKGGPITL	0.9903	0.8849	8	17
ING5-UTRN	chr2	242651486	chr6	145148484	508	HLA-B39:13	KHKGGPITL	0.9714	0.9234	8	17
ING5-UTRN	chr2	242651486	chr6	145148484	508	HLA-B38:02	KHKGGPITL	0.952	0.9735	8	17
ING5-UTRN	chr2	242651486	chr6	145148484	508	HLA-B38:01	KHKGGPITL	0.9355	0.9741	8	17
ING5-UTRN	chr2	242651486	chr6	145148484	508	HLA-B14:01	KHKGGPITL	0.9149	0.9317	8	17
ING5-UTRN	chr2	242651486	chr6	145148484	508	HLA-B14:02	KHKGGPITL	0.9149	0.9317	8	17
ING5-UTRN	chr2	242651486	chr6	145148484	508	HLA-B15:10	KHKGGPITL	0.703	0.7261	8	17
ING5-UTRN	chr2	242651486	chr6	145148484	508	HLA-B15:03	KHKGGPITL	0.6084	0.8887	8	17
ING5-UTRN	chr2	242651486	chr6	145148484	508	HLA-B15:18	KHKGGPITL	0.5962	0.8671	8	17
ING5-UTRN	chr2	242651486	chr6	145148484	508	HLA-B48:01	KHKGGPITL	0.4317	0.7275	8	17
ING5-UTRN	chr2	242651486	chr6	145148484	508	HLA-B15:37	KHKGGPITL	0.3509	0.7211	8	17
ING5-UTRN	chr2	242651486	chr6	145148484	508	HLA-B39:24	KKHKGGPITL	0.9657	0.7387	7	17
ING5-UTRN	chr2	242651486	chr6	145148484	508	HLA-B39:01	KKHKGGPITL	0.9269	0.8474	7	17
ING5-UTRN	chr2	242651486	chr6	145148484	508	HLA-B48:01	KKHKGGPITL	0.8775	0.7004	7	17
ING5-UTRN	chr2	242651486	chr6	145148484	508	HLA-B38:01	KKHKGGPITL	0.8634	0.9656	7	17
ING5-UTRN	chr2	242651486	chr6	145148484	508	HLA-B38:02	KKHKGGPITL	0.8485	0.9629	7	17
ING5-UTRN	chr2	242651486	chr6	145148484	508	HLA-B15:10	KKHKGGPITL	0.7611	0.6694	7	17
ING5-UTRN	chr2	242651486	chr6	145148484	508	HLA-B57:01	KGGPITLISMW	0.9998	0.8954	10	21
ING5-UTRN	chr2	242651486	chr6	145148484	508	HLA-B58:02	KGGPITLISMW	0.9996	0.8353	10	21
ING5-UTRN	chr2	242651486	chr6	145148484	508	HLA-B58:01	KGGPITLISMW	0.9989	0.7285	10	21
ING5-UTRN	chr2	242651486	chr6	145148484	508	HLA-B39:05	HKGGPITL	0.9979	0.9012	9	17
ING5-UTRN	chr2	242651486	chr6	145148484	508	HLA-B39:09	KHKGGPITL	0.991	0.8123	8	17
ING5-UTRN	chr2	242651486	chr6	145148484	508	HLA-B39:12	KHKGGPITL	0.9888	0.9114	8	17
ING5-UTRN	chr2	242651486	chr6	145148484	508	HLA-B39:05	KHKGGPITL	0.9352	0.887	8	17
ING5-UTRN	chr2	242651486	chr6	145148484	508	HLA-C07:27	KHKGGPITL	0.9188	0.9705	8	17
ING5-UTRN	chr2	242651486	chr6	145148484	508	HLA-C07:29	KHKGGPITL	0.9082	0.9289	8	17
ING5-UTRN	chr2	242651486	chr6	145148484	508	HLA-C07:05	KHKGGPITL	0.9054	0.9728	8	17
ING5-UTRN	chr2	242651486	chr6	145148484	508	HLA-C07:95	KHKGGPITL	0.9006	0.7434	8	17
ING5-UTRN	chr2	242651486	chr6	145148484	508	HLA-C07:13	KHKGGPITL	0.8853	0.9525	8	17
ING5-UTRN	chr2	242651486	chr6	145148484	508	HLA-C07:46	KHKGGPITL	0.8227	0.9321	8	17
ING5-UTRN	chr2	242651486	chr6	145148484	508	HLA-C07:80	KHKGGPITL	0.8128	0.9671	8	17
ING5-UTRN	chr2	242651486	chr6	145148484	508	HLA-C07:67	KHKGGPITL	0.8128	0.9671	8	17
ING5-UTRN	chr2	242651486	chr6	145148484	508	HLA-C07:19	KHKGGPITL	0.8061	0.8287	8	17
ING5-UTRN	chr2	242651486	chr6	145148484	508	HLA-C07:10	KHKGGPITL	0.7968	0.9761	8	17
ING5-UTRN	chr2	242651486	chr6	145148484	508	HLA-B14:03	KHKGGPITL	0.6238	0.916	8	17
ING5-UTRN	chr2	242651486	chr6	145148484	508	HLA-C01:17	GGPITLISM	0.6034	0.9399	11	20
ING5-UTRN	chr2	242651486	chr6	145148484	508	HLA-B39:08	KHKGGPITL	0.5722	0.9437	8	17
ING5-UTRN	chr2	242651486	chr6	145148484	508	HLA-C12:16	KHKGGPITL	0.2958	0.9807	8	17
ING5-UTRN	chr2	242651486	chr6	145148484	508	HLA-B48:03	KHKGGPITL	0.1567	0.6097	8	17
ING5-UTRN	chr2	242651486	chr6	145148484	508	HLA-B39:05	KKHKGGPITL	0.7826	0.8348	7	17
ING5-UTRN	chr2	242651486	chr6	145148484	508	HLA-B48:03	KKHKGGPITL	0.4582	0.5544	7	17
ING5-UTRN	chr2	242651486	chr6	145148484	508	HLA-B15:09	HKGGPITL	0.8959	0.7781	9	17
ING5-UTRN	chr2	242651486	chr6	145148484	508	HLA-B39:31	KHKGGPITL	0.9915	0.9126	8	17
ING5-UTRN	chr2	242651486	chr6	145148484	508	HLA-B39:02	KHKGGPITL	0.9903	0.9242	8	17
ING5-UTRN	chr2	242651486	chr6	145148484	508	HLA-B38:05	KHKGGPITL	0.9355	0.9741	8	17
ING5-UTRN	chr2	242651486	chr6	145148484	508	HLA-C07:17	KHKGGPITL	0.9087	0.9753	8	17
ING5-UTRN	chr2	242651486	chr6	145148484	508	HLA-C07:01	KHKGGPITL	0.9052	0.7519	8	17
ING5-UTRN	chr2	242651486	chr6	145148484	508	HLA-C07:22	KHKGGPITL	0.8163	0.7509	8	17
ING5-UTRN	chr2	242651486	chr6	145148484	508	HLA-C07:02	KHKGGPITL	0.8128	0.9671	8	17
ING5-UTRN	chr2	242651486	chr6	145148484	508	HLA-B27:06	KHKGGPITL	0.7673	0.787	8	17
ING5-UTRN	chr2	242651486	chr6	145148484	508	HLA-C06:08	KHKGGPITL	0.7355	0.9906	8	17
ING5-UTRN	chr2	242651486	chr6	145148484	508	HLA-B15:09	KHKGGPITL	0.7032	0.8127	8	17
ING5-UTRN	chr2	242651486	chr6	145148484	508	HLA-C07:04	KHKGGPITL	0.6255	0.973	8	17
ING5-UTRN	chr2	242651486	chr6	145148484	508	HLA-C01:02	GGPITLISM	0.5901	0.9422	11	20
ING5-UTRN	chr2	242651486	chr6	145148484	508	HLA-B39:11	KHKGGPITL	0.5631	0.9148	8	17
ING5-UTRN	chr2	242651486	chr6	145148484	508	HLA-C03:67	KHKGGPITL	0.5339	0.9866	8	17
ING5-UTRN	chr2	242651486	chr6	145148484	508	HLA-C06:06	KHKGGPITL	0.5161	0.9926	8	17
ING5-UTRN	chr2	242651486	chr6	145148484	508	HLA-C06:17	KHKGGPITL	0.473	0.9946	8	17
ING5-UTRN	chr2	242651486	chr6	145148484	508	HLA-C06:02	KHKGGPITL	0.473	0.9946	8	17
ING5-UTRN	chr2	242651486	chr6	145148484	508	HLA-B15:54	KHKGGPITL	0.3341	0.8962	8	17
ING5-UTRN	chr2	242651486	chr6	145148484	508	HLA-B15:68	KHKGGPITL	0.2974	0.7285	8	17
ING5-UTRN	chr2	242651486	chr6	145148484	508	HLA-B40:12	KHKGGPITL	0.1567	0.6097	8	17
ING5-UTRN	chr2	242651486	chr6	145148484	508	HLA-B15:68	KKHKGGPITL	0.9537	0.6861	7	17
ING5-UTRN	chr2	242651486	chr6	145148484	508	HLA-B38:05	KKHKGGPITL	0.8634	0.9656	7	17
ING5-UTRN	chr2	242651486	chr6	145148484	508	HLA-B15:09	KKHKGGPITL	0.5606	0.7853	7	17
ING5-UTRN	chr2	242651486	chr6	145148484	508	HLA-B40:12	KKHKGGPITL	0.4582	0.5544	7	17
ING5-UTRN	chr2	242651486	chr6	145148484	508	HLA-B57:10	KGGPITLISMW	0.9998	0.8954	10	21

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Potential FusionNeoAntigen Information of ING5-UTRN in HLA II

Potential FusionNeoAntigen Information
* We used NetMHCIIpan v4.1 (%rank<0.5).

Fusion gene

Hchr

Hbp

Tgene

Tchr

Tbp

HLA II

FusionNeoAntigen peptide

Neoantigen start (at BP 13)

Neoantigen end (at BP 13)

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Fusion breakpoint peptide structures of ING5-UTRN

3D structures of the fusion breakpoint peptide of 14AA sequence that have potential fusion neoantigens
* The minimum length of the amino acid sequence in RoseTTAFold is 14AA. Here, we predicted the 14AA fusion protein breakpoint sequence not the fusion neoantigen peptide, which is shorter than 14 AA.

File name	BPseq	Hgene	Tgene	Hchr	Hbp	Tchr	Tbp	AAlen
4340	KKKHKGGPITLISM	ING5	UTRN	chr2	242651486	chr6	145148484	508

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Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D of ING5-UTRN

Virtual screening between 25 HLAs (from PDB) and FusionNeoAntigens
* We used Glide to predict the interaction between HLAs and neoantigens.

HLA allele	PDB ID	File name	BPseq	Docking score	Glide score
HLA-B14:02	3BVN	4340	KKKHKGGPITLISM	-7.15543	-7.26883
HLA-B14:02	3BVN	4340	KKKHKGGPITLISM	-4.77435	-5.80965
HLA-B52:01	3W39	4340	KKKHKGGPITLISM	-6.80875	-6.92215
HLA-B52:01	3W39	4340	KKKHKGGPITLISM	-4.20386	-5.23916
HLA-A11:01	4UQ2	4340	KKKHKGGPITLISM	-7.5194	-8.5547
HLA-A11:01	4UQ2	4340	KKKHKGGPITLISM	-6.9601	-7.0735
HLA-A24:02	5HGA	4340	KKKHKGGPITLISM	-7.52403	-7.63743
HLA-A24:02	5HGA	4340	KKKHKGGPITLISM	-5.82433	-6.85963
HLA-B27:05	6PYJ	4340	KKKHKGGPITLISM	-3.28285	-4.31815
HLA-B44:05	3DX8	4340	KKKHKGGPITLISM	-5.91172	-6.94702
HLA-B44:05	3DX8	4340	KKKHKGGPITLISM	-4.24346	-4.35686

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Vaccine Design for the FusionNeoAntigens of ING5-UTRN

mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-Is.

Fusion gene	Hchr	Hbp	Tchr	Tbp	Start in +/-13AA	End in +/-13AA	FusionNeoAntigen peptide sequence	FusionNeoAntigen RNA sequence
ING5-UTRN	chr2	242651486	chr6	145148484	10	21	KGGPITLISMW	CAAAGGAGGTCCTATCACACTCATCAGTATGTG
ING5-UTRN	chr2	242651486	chr6	145148484	11	20	GGPITLISM	AGGAGGTCCTATCACACTCATCAGTAT
ING5-UTRN	chr2	242651486	chr6	145148484	7	17	KKHKGGPITL	AAAGAAGCACAAAGGAGGTCCTATCACACT
ING5-UTRN	chr2	242651486	chr6	145148484	8	17	KHKGGPITL	GAAGCACAAAGGAGGTCCTATCACACT
ING5-UTRN	chr2	242651486	chr6	145148484	9	17	HKGGPITL	GCACAAAGGAGGTCCTATCACACT

mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-IIs.

Fusion gene

Hchr

Hbp

Tchr

Tbp

Start in +/-13AA

End in +/-13AA

FusionNeoAntigen peptide

FusionNEoAntigen RNA sequence

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Information of the samples that have these potential fusion neoantigens of ING5-UTRN

These samples were reported as having these fusion breakpoints. For individual breakpoints, we checked the open reading frames considering multiple gene isoforms and chose the in-frame fusion genes only. Then, we made fusion protein sequences and predicted the fusion neoantigens. These fusion-positive samples may have these potential fusion neoantigens.

Cancer type	Fusion gene	Hchr	Hbp	Henst	Tchr	Tbp	Tenst	Sample
BRCA	ING5-UTRN	chr2	242651486	ENST00000313552	chr6	145148484	ENST00000367526	TCGA-GM-A2DN-01A

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Potential target of CAR-T therapy development for ING5-UTRN

Predicted 3D structure. We used RoseTTAFold.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, to provide the retention of the transmembrane domain, we only show the protein feature retention information of those transmembrane features

* Minus value of BPloci means that the break point is located before the CDS.

- In-frame and retained 'Transmembrane'.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Subcellular localization prediction of the transmembrane domain retained fusion proteins
* We used DeepLoc 1.0. The order of the X-axis of the barplot is as follows: Entry_ID, Localization, Type, Nucleus, Cytoplasm, Extracellular, Mitochondrion, Cell_membrane, Endoplasmic_reticulum, Plastid, Golgi.apparatus, Lysosome.Vacuole, Peroxisome. Y-axis is the output score of DeepLoc. Clicking the image will open a new tab with a large image.

Hgene

Hchr

Hbp

Henst

Tgene

Tchr

Tbp

Tenst

DeepLoc result

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Related Drugs to ING5-UTRN

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to ING5-UTRN

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source

	Fusion Gene and Fusion Protein Summary
	Fusion Amino Acid Sequences (multiple BPs and multiple gene isoforms)
	Fusion Protein Breakpoint Sequences - (for the Screening of the FusionNeoAntigens)
	Potential FusionNeoAntigens in HLA I - (netMHCpan v4.1 + deepHLApan v1.1)
	Potential FusionNeoAntigens in HLA II - (netMHCIIpan v4.1)
	Fusion Breakpoint 14 AA Peptide Structure - (RoseTTAFold)
	Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D - (Glide)
	Vaccine Design for the FusionNeoAntigens (RNA/protein sequences)
	Potential target of CAR-T therapy development
	Information on the samples that have these potential fusion neoantigens
	Fusion Protein Targeting Drugs - (Manual Curation)
	Fusion Protein Related diseases - (Manual Curation)