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Fusion Protein:JMJD1C-TTC8

Fusion Gene and Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: JMJD1C-TTC8
	FusionPDB ID: 40986
	FusionGDB2.0 ID: 40986
		Hgene	Tgene
	Gene symbol	JMJD1C	TTC8
	Gene ID	221037	123016
	Gene name	jumonji domain containing 1C	tetratricopeptide repeat domain 8
	Synonyms	KDM3C\|TRIP-8\|TRIP8	BBS8\|RP51
	Cytomap	10q21.3	14q31.3
	Type of gene	protein-coding	protein-coding
	Description	probable JmjC domain-containing histone demethylation protein 2CTR-interacting protein 8thyroid hormone receptor interactor 8thyroid receptor-interacting protein 8	tetratricopeptide repeat protein 8Bardet-Biedl syndrome type 8TPR repeat protein 8
	Modification date	20200313	20200313
	UniProtAcc	Q15652 Main function of 5'-partner protein: FUNCTION: Probable histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May be involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes (By similarity). {ECO:0000250}.	.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000399262, ENST00000399251, ENST00000402544, ENST00000489372, ENST00000542921,	ENST00000338104, ENST00000346301, ENST00000536576, ENST00000354441, ENST00000358622, ENST00000380656, ENST00000345383,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	29 X 18 X 10=5220	4 X 7 X 4=112
	# samples	31	6
	** MAII score	log2(31/5220*10)=-4.07370968618301 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(6/112*10)=-0.900464326449086 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Fusion gene context	PubMed: JMJD1C [Title/Abstract] AND TTC8 [Title/Abstract] AND fusion [Title/Abstract]
Fusion neoantigen context	PubMed: JMJD1C [Title/Abstract] AND TTC8 [Title/Abstract] AND neoantigen [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	JMJD1C(65140078)-TTC8(89305796), # samples:1
Anticipated loss of major functional domain due to fusion event.	JMJD1C-TTC8 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. JMJD1C-TTC8 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:65140078/chr14:89305796)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Retention analysis results of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features, are available here.

Fusion gene breakpoints across JMJD1C (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across TTC8 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Amino Acid Sequences

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000399262

JMJD1C

chr10

65140078

ENST00000345383

TTC8

chr14

89305796

2537

552

183

1955

590

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000399262	ENST00000345383	JMJD1C	chr10	65140078	-	TTC8	chr14	89305796	+	0.00096902	0.99903095

Predicted full-length fusion amino acid sequences. For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among all the predicted ones.

Get the fusion protein sequences from here.

Fusion protein sequence information is available in the fasta format.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

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Fusion Protein Breakpoint Sequences for JMJD1C-TTC8

+/-13 AA sequence from the breakpoints of the fusion protein sequences.

Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	Length(fusion protein)	BP in fusion protein	Peptide
JMJD1C	chr10	65140078	TTC8	chr14	89305796	552	123	QGSKSKQIQWPALAAWILKARALTEM

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Potential FusionNeoAntigen Information of JMJD1C-TTC8 in HLA I

Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.

JMJD1C-TTC8_65140078_89305796.msa

Potential FusionNeoAntigen Information
* We used NetMHCpan v4.1 (%rank<0.5) and deepHLApan v1.1 (immunogenic score>0.5)

Fusion gene	Hchr	Hbp	Tgene	Tchr	Tbp	HLA I	FusionNeoAntigen peptide	Binding score	Immunogenic score	Neoantigen start (at BP 13)	Neoantigen end (at BP 13)
JMJD1C-TTC8	chr10	65140078	chr14	89305796	552	HLA-A02:22	ALAAWILKA	0.9958	0.5829	11	20
JMJD1C-TTC8	chr10	65140078	chr14	89305796	552	HLA-A02:27	ALAAWILKA	0.9949	0.5828	11	20
JMJD1C-TTC8	chr10	65140078	chr14	89305796	552	HLA-A02:13	ALAAWILKA	0.9941	0.716	11	20
JMJD1C-TTC8	chr10	65140078	chr14	89305796	552	HLA-A02:38	ALAAWILKA	0.9923	0.7006	11	20
JMJD1C-TTC8	chr10	65140078	chr14	89305796	552	HLA-A02:60	ALAAWILKA	0.9914	0.5119	11	20
JMJD1C-TTC8	chr10	65140078	chr14	89305796	552	HLA-A02:21	ALAAWILKA	0.9901	0.5687	11	20
JMJD1C-TTC8	chr10	65140078	chr14	89305796	552	HLA-A02:19	ALAAWILKA	0.9838	0.5732	11	20
JMJD1C-TTC8	chr10	65140078	chr14	89305796	552	HLA-B35:03	WPALAAWIL	0.9808	0.8931	9	18
JMJD1C-TTC8	chr10	65140078	chr14	89305796	552	HLA-A31:08	IQWPALAAW	0.9744	0.9546	7	16
JMJD1C-TTC8	chr10	65140078	chr14	89305796	552	HLA-A02:04	ALAAWILKA	0.9732	0.7352	11	20
JMJD1C-TTC8	chr10	65140078	chr14	89305796	552	HLA-B35:02	WPALAAWIL	0.9376	0.9569	9	18
JMJD1C-TTC8	chr10	65140078	chr14	89305796	552	HLA-B35:04	WPALAAWIL	0.9376	0.9569	9	18
JMJD1C-TTC8	chr10	65140078	chr14	89305796	552	HLA-B57:01	IQWPALAAW	0.9167	0.9956	7	16
JMJD1C-TTC8	chr10	65140078	chr14	89305796	552	HLA-A32:13	IQWPALAAW	0.9063	0.9989	7	16
JMJD1C-TTC8	chr10	65140078	chr14	89305796	552	HLA-B58:01	IQWPALAAW	0.8911	0.9951	7	16
JMJD1C-TTC8	chr10	65140078	chr14	89305796	552	HLA-A31:02	LAAWILKAR	0.8831	0.7274	12	21
JMJD1C-TTC8	chr10	65140078	chr14	89305796	552	HLA-A02:21	KQIQWPALA	0.8682	0.8301	5	14
JMJD1C-TTC8	chr10	65140078	chr14	89305796	552	HLA-B13:02	KQIQWPALA	0.8485	0.9936	5	14
JMJD1C-TTC8	chr10	65140078	chr14	89305796	552	HLA-B15:16	IQWPALAAW	0.8478	0.9859	7	16
JMJD1C-TTC8	chr10	65140078	chr14	89305796	552	HLA-B57:03	IQWPALAAW	0.7987	0.9986	7	16
JMJD1C-TTC8	chr10	65140078	chr14	89305796	552	HLA-B58:02	IQWPALAAW	0.7785	0.9927	7	16
JMJD1C-TTC8	chr10	65140078	chr14	89305796	552	HLA-B15:03	IQWPALAAW	0.6136	0.9338	7	16
JMJD1C-TTC8	chr10	65140078	chr14	89305796	552	HLA-A24:14	IQWPALAAW	0.5278	0.8793	7	16
JMJD1C-TTC8	chr10	65140078	chr14	89305796	552	HLA-B50:01	KQIQWPALA	0.4315	0.9535	5	14
JMJD1C-TTC8	chr10	65140078	chr14	89305796	552	HLA-B13:01	IQWPALAAW	0.3761	0.9977	7	16
JMJD1C-TTC8	chr10	65140078	chr14	89305796	552	HLA-B81:01	WPALAAWIL	0.3295	0.9249	9	18
JMJD1C-TTC8	chr10	65140078	chr14	89305796	552	HLA-B82:01	WPALAAWIL	0.1066	0.8828	9	18
JMJD1C-TTC8	chr10	65140078	chr14	89305796	552	HLA-B52:01	IQWPALAAW	0.0432	0.9988	7	16
JMJD1C-TTC8	chr10	65140078	chr14	89305796	552	HLA-A74:09	ALAAWILKAR	0.9647	0.7417	11	21
JMJD1C-TTC8	chr10	65140078	chr14	89305796	552	HLA-A74:11	ALAAWILKAR	0.9647	0.7417	11	21
JMJD1C-TTC8	chr10	65140078	chr14	89305796	552	HLA-A74:03	ALAAWILKAR	0.9647	0.7417	11	21
JMJD1C-TTC8	chr10	65140078	chr14	89305796	552	HLA-A32:13	QIQWPALAAW	0.8348	0.9958	6	16
JMJD1C-TTC8	chr10	65140078	chr14	89305796	552	HLA-A31:08	KQIQWPALAAW	0.9967	0.9657	5	16
JMJD1C-TTC8	chr10	65140078	chr14	89305796	552	HLA-A32:13	KQIQWPALAAW	0.9811	0.9958	5	16
JMJD1C-TTC8	chr10	65140078	chr14	89305796	552	HLA-A02:02	ALAAWILKA	0.9956	0.5547	11	20
JMJD1C-TTC8	chr10	65140078	chr14	89305796	552	HLA-A02:05	ALAAWILKA	0.9948	0.6427	11	20
JMJD1C-TTC8	chr10	65140078	chr14	89305796	552	HLA-B15:07	IQWPALAAW	0.957	0.9113	7	16
JMJD1C-TTC8	chr10	65140078	chr14	89305796	552	HLA-B56:04	WPALAAWIL	0.9536	0.7835	9	18
JMJD1C-TTC8	chr10	65140078	chr14	89305796	552	HLA-B35:12	WPALAAWIL	0.9376	0.9569	9	18
JMJD1C-TTC8	chr10	65140078	chr14	89305796	552	HLA-A02:05	KQIQWPALA	0.8765	0.818	5	14
JMJD1C-TTC8	chr10	65140078	chr14	89305796	552	HLA-B39:10	WPALAAWIL	0.8732	0.9802	9	18
JMJD1C-TTC8	chr10	65140078	chr14	89305796	552	HLA-B15:04	KQIQWPALA	0.7113	0.986	5	14
JMJD1C-TTC8	chr10	65140078	chr14	89305796	552	HLA-B15:05	IQWPALAAW	0.6777	0.9093	7	16
JMJD1C-TTC8	chr10	65140078	chr14	89305796	552	HLA-B44:08	IQWPALAAW	0.5866	0.8221	7	16
JMJD1C-TTC8	chr10	65140078	chr14	89305796	552	HLA-B15:04	KQIQWPALAA	0.9625	0.9816	5	15
JMJD1C-TTC8	chr10	65140078	chr14	89305796	552	HLA-B44:08	QIQWPALAAW	0.6895	0.9421	6	16
JMJD1C-TTC8	chr10	65140078	chr14	89305796	552	HLA-A02:03	ALAAWILKA	0.9973	0.6839	11	20
JMJD1C-TTC8	chr10	65140078	chr14	89305796	552	HLA-B15:24	IQWPALAAW	0.9965	0.9911	7	16
JMJD1C-TTC8	chr10	65140078	chr14	89305796	552	HLA-A02:06	ALAAWILKA	0.9901	0.5687	11	20
JMJD1C-TTC8	chr10	65140078	chr14	89305796	552	HLA-A02:14	ALAAWILKA	0.9899	0.5785	11	20
JMJD1C-TTC8	chr10	65140078	chr14	89305796	552	HLA-B15:27	IQWPALAAW	0.9799	0.9319	7	16
JMJD1C-TTC8	chr10	65140078	chr14	89305796	552	HLA-B35:23	WPALAAWIL	0.974	0.8958	9	18
JMJD1C-TTC8	chr10	65140078	chr14	89305796	552	HLA-A32:01	IQWPALAAW	0.9713	0.9972	7	16
JMJD1C-TTC8	chr10	65140078	chr14	89305796	552	HLA-B55:04	WPALAAWIL	0.9647	0.8048	9	18
JMJD1C-TTC8	chr10	65140078	chr14	89305796	552	HLA-B15:53	IQWPALAAW	0.9622	0.9257	7	16
JMJD1C-TTC8	chr10	65140078	chr14	89305796	552	HLA-B56:02	WPALAAWIL	0.9536	0.7835	9	18
JMJD1C-TTC8	chr10	65140078	chr14	89305796	552	HLA-B57:04	IQWPALAAW	0.9496	0.8418	7	16
JMJD1C-TTC8	chr10	65140078	chr14	89305796	552	HLA-B15:35	IQWPALAAW	0.9453	0.9385	7	16
JMJD1C-TTC8	chr10	65140078	chr14	89305796	552	HLA-B35:22	WPALAAWIL	0.9427	0.7712	9	18
JMJD1C-TTC8	chr10	65140078	chr14	89305796	552	HLA-B35:09	WPALAAWIL	0.9376	0.9569	9	18
JMJD1C-TTC8	chr10	65140078	chr14	89305796	552	HLA-B57:10	IQWPALAAW	0.9167	0.9956	7	16
JMJD1C-TTC8	chr10	65140078	chr14	89305796	552	HLA-B35:24	WPALAAWIL	0.903	0.9049	9	18
JMJD1C-TTC8	chr10	65140078	chr14	89305796	552	HLA-B15:13	IQWPALAAW	0.8964	0.9768	7	16
JMJD1C-TTC8	chr10	65140078	chr14	89305796	552	HLA-B67:01	WPALAAWIL	0.8934	0.9836	9	18
JMJD1C-TTC8	chr10	65140078	chr14	89305796	552	HLA-A02:14	KQIQWPALA	0.8692	0.8399	5	14
JMJD1C-TTC8	chr10	65140078	chr14	89305796	552	HLA-A02:06	KQIQWPALA	0.8682	0.8301	5	14
JMJD1C-TTC8	chr10	65140078	chr14	89305796	552	HLA-B53:02	WPALAAWIL	0.8444	0.7804	9	18
JMJD1C-TTC8	chr10	65140078	chr14	89305796	552	HLA-B58:06	IQWPALAAW	0.8215	0.9908	7	16
JMJD1C-TTC8	chr10	65140078	chr14	89305796	552	HLA-B15:54	IQWPALAAW	0.8078	0.9204	7	16
JMJD1C-TTC8	chr10	65140078	chr14	89305796	552	HLA-B51:06	WPALAAWIL	0.7923	0.8893	9	18
JMJD1C-TTC8	chr10	65140078	chr14	89305796	552	HLA-B57:02	IQWPALAAW	0.7635	0.9897	7	16
JMJD1C-TTC8	chr10	65140078	chr14	89305796	552	HLA-B15:20	IQWPALAAW	0.6798	0.9158	7	16
JMJD1C-TTC8	chr10	65140078	chr14	89305796	552	HLA-B35:28	IQWPALAAW	0.67	0.9155	7	16
JMJD1C-TTC8	chr10	65140078	chr14	89305796	552	HLA-B15:68	IQWPALAAW	0.6394	0.8994	7	16
JMJD1C-TTC8	chr10	65140078	chr14	89305796	552	HLA-B48:02	IQWPALAAW	0.6194	0.9153	7	16
JMJD1C-TTC8	chr10	65140078	chr14	89305796	552	HLA-B50:04	KQIQWPALA	0.4315	0.9535	5	14
JMJD1C-TTC8	chr10	65140078	chr14	89305796	552	HLA-B50:05	KQIQWPALA	0.4315	0.9535	5	14
JMJD1C-TTC8	chr10	65140078	chr14	89305796	552	HLA-B49:03	KQIQWPALA	0.2099	0.585	5	14
JMJD1C-TTC8	chr10	65140078	chr14	89305796	552	HLA-B82:02	WPALAAWIL	0.1066	0.8828	9	18
JMJD1C-TTC8	chr10	65140078	chr14	89305796	552	HLA-B15:24	QIQWPALAAW	0.9886	0.9925	6	16
JMJD1C-TTC8	chr10	65140078	chr14	89305796	552	HLA-A74:01	ALAAWILKAR	0.9647	0.7417	11	21
JMJD1C-TTC8	chr10	65140078	chr14	89305796	552	HLA-B15:13	QIQWPALAAW	0.9534	0.994	6	16
JMJD1C-TTC8	chr10	65140078	chr14	89305796	552	HLA-A32:01	QIQWPALAAW	0.9164	0.9955	6	16
JMJD1C-TTC8	chr10	65140078	chr14	89305796	552	HLA-A25:01	QIQWPALAAW	0.2834	0.981	6	16
JMJD1C-TTC8	chr10	65140078	chr14	89305796	552	HLA-B15:24	KQIQWPALAAW	0.9996	0.9907	5	16
JMJD1C-TTC8	chr10	65140078	chr14	89305796	552	HLA-A32:01	KQIQWPALAAW	0.995	0.9966	5	16

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Potential FusionNeoAntigen Information of JMJD1C-TTC8 in HLA II

Potential FusionNeoAntigen Information
* We used NetMHCIIpan v4.1 (%rank<0.5).

Fusion gene

Hchr

Hbp

Tgene

Tchr

Tbp

HLA II

FusionNeoAntigen peptide

Neoantigen start (at BP 13)

Neoantigen end (at BP 13)

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Fusion breakpoint peptide structures of JMJD1C-TTC8

3D structures of the fusion breakpoint peptide of 14AA sequence that have potential fusion neoantigens
* The minimum length of the amino acid sequence in RoseTTAFold is 14AA. Here, we predicted the 14AA fusion protein breakpoint sequence not the fusion neoantigen peptide, which is shorter than 14 AA.

File name	BPseq	Hgene	Tgene	Hchr	Hbp	Tchr	Tbp	AAlen
7327	QIQWPALAAWILKA	JMJD1C	TTC8	chr10	65140078	chr14	89305796	552

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Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D of JMJD1C-TTC8

Virtual screening between 25 HLAs (from PDB) and FusionNeoAntigens
* We used Glide to predict the interaction between HLAs and neoantigens.

HLA allele	PDB ID	File name	BPseq	Docking score	Glide score
HLA-B14:02	3BVN	7327	QIQWPALAAWILKA	-7.63753	-7.75093
HLA-B14:02	3BVN	7327	QIQWPALAAWILKA	-4.36349	-5.39879
HLA-B52:01	3W39	7327	QIQWPALAAWILKA	-6.74822	-6.86162
HLA-B52:01	3W39	7327	QIQWPALAAWILKA	-4.96916	-6.00446
HLA-A24:02	5HGA	7327	QIQWPALAAWILKA	-8.26666	-9.30196
HLA-A24:02	5HGA	7327	QIQWPALAAWILKA	-7.6208	-7.7342
HLA-B27:03	6PZ5	7327	QIQWPALAAWILKA	0.0420189	-0.993281
HLA-B44:05	3DX8	7327	QIQWPALAAWILKA	-5.06122	-5.17462
HLA-B44:05	3DX8	7327	QIQWPALAAWILKA	-4.87073	-5.90603

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Vaccine Design for the FusionNeoAntigens of JMJD1C-TTC8

mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-Is.

Fusion gene	Hchr	Hbp	Tchr	Tbp	Start in +/-13AA	End in +/-13AA	FusionNeoAntigen peptide sequence	FusionNeoAntigen RNA sequence
JMJD1C-TTC8	chr10	65140078	chr14	89305796	11	20	ALAAWILKA	GCATTGGCAGCTTGGATCTTAAAAGCA
JMJD1C-TTC8	chr10	65140078	chr14	89305796	11	21	ALAAWILKAR	GCATTGGCAGCTTGGATCTTAAAAGCAAGA
JMJD1C-TTC8	chr10	65140078	chr14	89305796	12	21	LAAWILKAR	TTGGCAGCTTGGATCTTAAAAGCAAGA
JMJD1C-TTC8	chr10	65140078	chr14	89305796	5	14	KQIQWPALA	AAACAGATTCAGTGGCCTGCATTGGCA
JMJD1C-TTC8	chr10	65140078	chr14	89305796	5	15	KQIQWPALAA	AAACAGATTCAGTGGCCTGCATTGGCAGCT
JMJD1C-TTC8	chr10	65140078	chr14	89305796	5	16	KQIQWPALAAW	AAACAGATTCAGTGGCCTGCATTGGCAGCTTGG
JMJD1C-TTC8	chr10	65140078	chr14	89305796	6	16	QIQWPALAAW	CAGATTCAGTGGCCTGCATTGGCAGCTTGG
JMJD1C-TTC8	chr10	65140078	chr14	89305796	7	16	IQWPALAAW	ATTCAGTGGCCTGCATTGGCAGCTTGG
JMJD1C-TTC8	chr10	65140078	chr14	89305796	9	18	WPALAAWIL	TGGCCTGCATTGGCAGCTTGGATCTTA

mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-IIs.

Fusion gene

Hchr

Hbp

Tchr

Tbp

Start in +/-13AA

End in +/-13AA

FusionNeoAntigen peptide

FusionNEoAntigen RNA sequence

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Information of the samples that have these potential fusion neoantigens of JMJD1C-TTC8

These samples were reported as having these fusion breakpoints. For individual breakpoints, we checked the open reading frames considering multiple gene isoforms and chose the in-frame fusion genes only. Then, we made fusion protein sequences and predicted the fusion neoantigens. These fusion-positive samples may have these potential fusion neoantigens.

Cancer type	Fusion gene	Hchr	Hbp	Henst	Tchr	Tbp	Tenst	Sample
STAD	JMJD1C-TTC8	chr10	65140078	ENST00000399262	chr14	89305796	ENST00000345383	TCGA-BR-8078-01A

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Potential target of CAR-T therapy development for JMJD1C-TTC8

Predicted 3D structure. We used RoseTTAFold.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, to provide the retention of the transmembrane domain, we only show the protein feature retention information of those transmembrane features

* Minus value of BPloci means that the break point is located before the CDS.

- In-frame and retained 'Transmembrane'.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Subcellular localization prediction of the transmembrane domain retained fusion proteins
* We used DeepLoc 1.0. The order of the X-axis of the barplot is as follows: Entry_ID, Localization, Type, Nucleus, Cytoplasm, Extracellular, Mitochondrion, Cell_membrane, Endoplasmic_reticulum, Plastid, Golgi.apparatus, Lysosome.Vacuole, Peroxisome. Y-axis is the output score of DeepLoc. Clicking the image will open a new tab with a large image.

Hgene

Hchr

Hbp

Henst

Tgene

Tchr

Tbp

Tenst

DeepLoc result

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Related Drugs to JMJD1C-TTC8

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to JMJD1C-TTC8

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	JMJD1C	C0004352	Autistic Disorder	1	CTD_human
Hgene	JMJD1C	C0010606	Adenoid Cystic Carcinoma	1	CTD_human
Hgene	JMJD1C	C0012236	DiGeorge Syndrome	1	ORPHANET
Hgene	JMJD1C	C0087031	Juvenile-Onset Still Disease	1	CTD_human
Hgene	JMJD1C	C0220704	Shprintzen syndrome	1	ORPHANET
Hgene	JMJD1C	C0431406	Asymmetric crying face association	1	ORPHANET
Hgene	JMJD1C	C0795907	CONOTRUNCAL ANOMALY FACE SYNDROME	1	ORPHANET
Hgene	JMJD1C	C1333813	Central Nervous System Germinoma	1	ORPHANET
Hgene	JMJD1C	C2936346	22q11 Deletion Syndrome	1	ORPHANET
Hgene	JMJD1C	C3266101	22q11 partial monosomy syndrome	1	ORPHANET
Hgene	JMJD1C	C3495559	Juvenile arthritis	1	CTD_human
Hgene	JMJD1C	C3714758	Juvenile psoriatic arthritis	1	CTD_human
Hgene	JMJD1C	C4552091	Polyarthritis, Juvenile, Rheumatoid Factor Negative	1	CTD_human
Hgene	JMJD1C	C4704862	Polyarthritis, Juvenile, Rheumatoid Factor Positive	1	CTD_human

	Fusion Gene and Fusion Protein Summary
	Fusion Amino Acid Sequences (multiple BPs and multiple gene isoforms)
	Fusion Protein Breakpoint Sequences - (for the Screening of the FusionNeoAntigens)
	Potential FusionNeoAntigens in HLA I - (netMHCpan v4.1 + deepHLApan v1.1)
	Potential FusionNeoAntigens in HLA II - (netMHCIIpan v4.1)
	Fusion Breakpoint 14 AA Peptide Structure - (RoseTTAFold)
	Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D - (Glide)
	Vaccine Design for the FusionNeoAntigens (RNA/protein sequences)
	Potential target of CAR-T therapy development
	Information on the samples that have these potential fusion neoantigens
	Fusion Protein Targeting Drugs - (Manual Curation)
	Fusion Protein Related diseases - (Manual Curation)