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Center for Computational Systems Medicine
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Fusion Gene and Fusion Protein Summary

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Fusion Amino Acid Sequences (multiple BPs and multiple gene isoforms)

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Fusion Protein Breakpoint Sequences - (for the Screening of the FusionNeoAntigens)

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Potential FusionNeoAntigens in HLA I - (netMHCpan v4.1 + deepHLApan v1.1)

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Potential FusionNeoAntigens in HLA II - (netMHCIIpan v4.1)

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Fusion Breakpoint 14 AA Peptide Structure - (RoseTTAFold)

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Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D - (Glide)

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Vaccine Design for the FusionNeoAntigens (RNA/protein sequences)

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Potential target of CAR-T therapy development

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Information on the samples that have these potential fusion neoantigens

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Fusion Protein Targeting Drugs - (Manual Curation)

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Fusion Protein Related diseases - (Manual Curation)

Fusion Protein:KAT6B-CCDC172

Fusion Gene and Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: KAT6B-CCDC172
FusionPDB ID: 41226
FusionGDB2.0 ID: 41226
HgeneTgene
Gene symbol

KAT6B

CCDC172

Gene ID

23522

374355

Gene namelysine acetyltransferase 6Bcoiled-coil domain containing 172
SynonymsGTPTS|MORF|MOZ2|MYST4|ZC2HC6B|qkf|querkopfC10orf96
Cytomap

10q22.2

10q25.3

Type of geneprotein-codingprotein-coding
Descriptionhistone acetyltransferase KAT6BK(lysine) acetyltransferase 6BMOZ, YBF2/SAS3, SAS2 and TIP60 protein 4MOZ-related factorMYST histone acetyltransferase (monocytic leukemia) 4MYST-4histone acetyltransferase MORFhistone acetyltransferase MOZ2histone acoiled-coil domain-containing protein 172UPF0628 protein C10orf96
Modification date2020031320200313
UniProtAcc

Q8WYB5

Main function of 5'-partner protein: FUNCTION: Histone acetyltransferase which may be involved in both positive and negative regulation of transcription. Required for RUNX2-dependent transcriptional activation. May be involved in cerebral cortex development. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. {ECO:0000269|PubMed:10497217, ECO:0000269|PubMed:11965546, ECO:0000269|PubMed:16387653}.		.
Ensembl transtripts involved in fusion geneENST idsENST00000490365, ENST00000287239, 
ENST00000372711, ENST00000372714, 
ENST00000372724, ENST00000372725, 
ENST00000333254, ENST00000497093, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score23 X 21 X 10=48301 X 3 X 1=3
# samples 321
** MAII scorelog2(32/4830*10)=-3.91587937883577
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(1/3*10)=1.73696559416621
Fusion gene context

PubMed: KAT6B [Title/Abstract] AND CCDC172 [Title/Abstract] AND fusion [Title/Abstract]

Fusion neoantigen context

PubMed: KAT6B [Title/Abstract] AND CCDC172 [Title/Abstract] AND neoantigen [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)KAT6B(76741686)-CCDC172(118100246), # samples:2
Anticipated loss of major functional domain due to fusion event.KAT6B-CCDC172 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
KAT6B-CCDC172 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
KAT6B-CCDC172 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
KAT6B-CCDC172 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneKAT6B

GO:0016573

histone acetylation

11965546

HgeneKAT6B

GO:0043966

histone H3 acetylation

16387653

HgeneKAT6B

GO:0045892

negative regulation of transcription, DNA-templated

10497217

HgeneKAT6B

GO:0045893

positive regulation of transcription, DNA-templated

10497217|11965546



check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:76741686/chr10:118100246)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonRetention analysis results of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features, are available here.

check buttonFusion gene breakpoints across KAT6B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CCDC172 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Amino Acid Sequences


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000372725KAT6Bchr1076741686+ENST00000333254CCDC172chr10118100246+313118483422459705
ENST00000372724KAT6Bchr1076741686+ENST00000333254CCDC172chr10118100246+329420115052622705
ENST00000287239KAT6Bchr1076741686+ENST00000333254CCDC172chr10118100246+414528624803473997
ENST00000372714KAT6Bchr1076741686+ENST00000333254CCDC172chr10118100246+318218993932510705
ENST00000372711KAT6Bchr1076741686+ENST00000333254CCDC172chr10118100246+341821353022746814
ENST00000372725KAT6Bchr1076741686+ENST00000333254CCDC172chr10118100282+309418483421853503
ENST00000372724KAT6Bchr1076741686+ENST00000333254CCDC172chr10118100282+325720115052016503
ENST00000287239KAT6Bchr1076741686+ENST00000333254CCDC172chr10118100282+410828624802867795
ENST00000372714KAT6Bchr1076741686+ENST00000333254CCDC172chr10118100282+314518993931904503
ENST00000372711KAT6Bchr1076741686+ENST00000333254CCDC172chr10118100282+338121353022140612
ENST00000372725KAT6Bchr1076741685+ENST00000333254CCDC172chr10118100245+313118483422459705
ENST00000372724KAT6Bchr1076741685+ENST00000333254CCDC172chr10118100245+329420115052622705
ENST00000287239KAT6Bchr1076741685+ENST00000333254CCDC172chr10118100245+414528624803473997
ENST00000372714KAT6Bchr1076741685+ENST00000333254CCDC172chr10118100245+318218993932510705
ENST00000372711KAT6Bchr1076741685+ENST00000333254CCDC172chr10118100245+341821353022746814

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000372725ENST00000333254KAT6Bchr1076741686+CCDC172chr10118100246+0.0002239210.99977607
ENST00000372724ENST00000333254KAT6Bchr1076741686+CCDC172chr10118100246+0.0002297450.9997702
ENST00000287239ENST00000333254KAT6Bchr1076741686+CCDC172chr10118100246+0.0001620610.9998379
ENST00000372714ENST00000333254KAT6Bchr1076741686+CCDC172chr10118100246+0.0002320210.99976796
ENST00000372711ENST00000333254KAT6Bchr1076741686+CCDC172chr10118100246+0.0001675460.9998324
ENST00000372725ENST00000333254KAT6Bchr1076741686+CCDC172chr10118100282+0.0003529820.999647
ENST00000372724ENST00000333254KAT6Bchr1076741686+CCDC172chr10118100282+0.0003430290.9996569
ENST00000287239ENST00000333254KAT6Bchr1076741686+CCDC172chr10118100282+0.0004627770.9995372
ENST00000372714ENST00000333254KAT6Bchr1076741686+CCDC172chr10118100282+0.0003588040.9996412
ENST00000372711ENST00000333254KAT6Bchr1076741686+CCDC172chr10118100282+0.0002185180.99978155
ENST00000372725ENST00000333254KAT6Bchr1076741685+CCDC172chr10118100245+0.0002239210.99977607
ENST00000372724ENST00000333254KAT6Bchr1076741685+CCDC172chr10118100245+0.0002297450.9997702
ENST00000287239ENST00000333254KAT6Bchr1076741685+CCDC172chr10118100245+0.0001620610.9998379
ENST00000372714ENST00000333254KAT6Bchr1076741685+CCDC172chr10118100245+0.0002320210.99976796
ENST00000372711ENST00000333254KAT6Bchr1076741685+CCDC172chr10118100245+0.0001675460.9998324

check button Predicted full-length fusion amino acid sequences. For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among all the predicted ones.

Get the fusion protein sequences from here.

Fusion protein sequence information is available in the fasta format.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

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Fusion Protein Breakpoint Sequences for KAT6B-CCDC172

check button +/-13 AA sequence from the breakpoints of the fusion protein sequences.
HgeneHchrHbpTgeneTchrTbpLength(fusion protein)BP in fusion proteinPeptide
KAT6Bchr1076741685CCDC172chr101181002451848502NEIYRRKDLSVFEVQQFFEKSFFLQL
KAT6Bchr1076741685CCDC172chr101181002451899502NEIYRRKDLSVFEVQQFFEKSFFLQL
KAT6Bchr1076741685CCDC172chr101181002452011502NEIYRRKDLSVFEVQQFFEKSFFLQL
KAT6Bchr1076741685CCDC172chr101181002452135611NEIYRRKDLSVFEVQQFFEKSFFLQL
KAT6Bchr1076741685CCDC172chr101181002452862794NEIYRRKDLSVFEVQQFFEKSFFLQL
KAT6Bchr1076741686CCDC172chr101181002461848502NEIYRRKDLSVFEVQQFFEKSFFLQL
KAT6Bchr1076741686CCDC172chr101181002461899502NEIYRRKDLSVFEVQQFFEKSFFLQL
KAT6Bchr1076741686CCDC172chr101181002462011502NEIYRRKDLSVFEVQQFFEKSFFLQL
KAT6Bchr1076741686CCDC172chr101181002462135611NEIYRRKDLSVFEVQQFFEKSFFLQL
KAT6Bchr1076741686CCDC172chr101181002462862794NEIYRRKDLSVFEVQQFFEKSFFLQL

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Potential FusionNeoAntigen Information of KAT6B-CCDC172 in HLA I

check button Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.
KAT6B-CCDC172_76741685_118100245.msa

check button Potential FusionNeoAntigen Information
* We used NetMHCpan v4.1 (%rank<0.5) and deepHLApan v1.1 (immunogenic score>0.5)
Fusion geneHchrHbpTgeneTchrTbpHLA IFusionNeoAntigen peptideBinding scoreImmunogenic scoreNeoantigen start (at BP 13)Neoantigen end (at BP 13)
KAT6B-CCDC172chr1076741685chr101181002452862HLA-B15:25SVFEVQQFF0.9980.7566918
KAT6B-CCDC172chr1076741685chr101181002452862HLA-B57:01LSVFEVQQF0.99750.9444817
KAT6B-CCDC172chr1076741685chr101181002452862HLA-B35:08SVFEVQQFF0.99680.6324918
KAT6B-CCDC172chr1076741685chr101181002452862HLA-B15:02SVFEVQQFF0.99670.7686918
KAT6B-CCDC172chr1076741685chr101181002452862HLA-B15:17LSVFEVQQF0.99660.8135817
KAT6B-CCDC172chr1076741685chr101181002452862HLA-B15:16LSVFEVQQF0.99630.5412817
KAT6B-CCDC172chr1076741685chr101181002452862HLA-B58:02LSVFEVQQF0.99560.8406817
KAT6B-CCDC172chr1076741685chr101181002452862HLA-B58:01LSVFEVQQF0.99530.8211817
KAT6B-CCDC172chr1076741685chr101181002452862HLA-B15:17SVFEVQQFF0.99430.6732918
KAT6B-CCDC172chr1076741685chr101181002452862HLA-B57:03LSVFEVQQF0.99230.9275817
KAT6B-CCDC172chr1076741685chr101181002452862HLA-B35:01SVFEVQQFF0.98590.7558918
KAT6B-CCDC172chr1076741685chr101181002452862HLA-B57:01SVFEVQQFF0.96660.9191918
KAT6B-CCDC172chr1076741685chr101181002452862HLA-B15:01SVFEVQQFF0.96510.6845918
KAT6B-CCDC172chr1076741685chr101181002452862HLA-B58:01SVFEVQQFF0.95960.7437918
KAT6B-CCDC172chr1076741685chr101181002452862HLA-B58:02SVFEVQQFF0.94790.8099918
KAT6B-CCDC172chr1076741685chr101181002452862HLA-A32:13SVFEVQQFF0.93860.9241918
KAT6B-CCDC172chr1076741685chr101181002452862HLA-B57:03SVFEVQQFF0.93430.8078918
KAT6B-CCDC172chr1076741685chr101181002452862HLA-B52:01SVFEVQQFF0.36980.7583918
KAT6B-CCDC172chr1076741685chr101181002452862HLA-B13:01SVFEVQQFF0.24480.6972918
KAT6B-CCDC172chr1076741685chr101181002452862HLA-B57:01LSVFEVQQFF0.99950.9036818
KAT6B-CCDC172chr1076741685chr101181002452862HLA-B27:05RRKDLSVFEV0.99940.8047414
KAT6B-CCDC172chr1076741685chr101181002452862HLA-B27:07RRKDLSVFEV0.99930.7174414
KAT6B-CCDC172chr1076741685chr101181002452862HLA-B27:04RRKDLSVFEV0.99910.8307414
KAT6B-CCDC172chr1076741685chr101181002452862HLA-B57:03LSVFEVQQFF0.99870.8766818
KAT6B-CCDC172chr1076741685chr101181002452862HLA-B58:02LSVFEVQQFF0.9980.7853818
KAT6B-CCDC172chr1076741685chr101181002452862HLA-B15:17LSVFEVQQFF0.99710.6977818
KAT6B-CCDC172chr1076741685chr101181002452862HLA-B58:01LSVFEVQQFF0.99630.7223818
KAT6B-CCDC172chr1076741685chr101181002452862HLA-B57:01KDLSVFEVQQF0.99940.9556617
KAT6B-CCDC172chr1076741685chr101181002452862HLA-B57:03KDLSVFEVQQF0.9990.9672617
KAT6B-CCDC172chr1076741685chr101181002452862HLA-B58:01KDLSVFEVQQF0.99370.9045617
KAT6B-CCDC172chr1076741685chr101181002452862HLA-C04:07VFEVQQFF0.99850.85341018
KAT6B-CCDC172chr1076741685chr101181002452862HLA-C04:10VFEVQQFF0.99840.82611018
KAT6B-CCDC172chr1076741685chr101181002452862HLA-C04:14VFEVQQFF0.99030.861018
KAT6B-CCDC172chr1076741685chr101181002452862HLA-B15:21SVFEVQQFF0.9970.7199918
KAT6B-CCDC172chr1076741685chr101181002452862HLA-C15:04LSVFEVQQF0.99280.8393817
KAT6B-CCDC172chr1076741685chr101181002452862HLA-B15:05SVFEVQQFF0.98780.7581918
KAT6B-CCDC172chr1076741685chr101181002452862HLA-B15:31SVFEVQQFF0.98290.7705918
KAT6B-CCDC172chr1076741685chr101181002452862HLA-C15:04SVFEVQQFF0.98040.8256918
KAT6B-CCDC172chr1076741685chr101181002452862HLA-C15:06SVFEVQQFF0.97250.8324918
KAT6B-CCDC172chr1076741685chr101181002452862HLA-C03:19SVFEVQQFF0.97250.9784918
KAT6B-CCDC172chr1076741685chr101181002452862HLA-C03:08SVFEVQQFF0.9660.772918
KAT6B-CCDC172chr1076741685chr101181002452862HLA-C03:07SVFEVQQFF0.95760.9148918
KAT6B-CCDC172chr1076741685chr101181002452862HLA-C03:14LSVFEVQQF0.92710.9718817
KAT6B-CCDC172chr1076741685chr101181002452862HLA-C07:10SVFEVQQFF0.92680.9365918
KAT6B-CCDC172chr1076741685chr101181002452862HLA-C04:06SVFEVQQFF0.90730.7451918
KAT6B-CCDC172chr1076741685chr101181002452862HLA-C07:67SVFEVQQFF0.90370.9271918
KAT6B-CCDC172chr1076741685chr101181002452862HLA-C07:80SVFEVQQFF0.90370.9271918
KAT6B-CCDC172chr1076741685chr101181002452862HLA-C07:05SVFEVQQFF0.89970.9519918
KAT6B-CCDC172chr1076741685chr101181002452862HLA-C07:19SVFEVQQFF0.89430.7027918
KAT6B-CCDC172chr1076741685chr101181002452862HLA-C07:27SVFEVQQFF0.88660.9357918
KAT6B-CCDC172chr1076741685chr101181002452862HLA-C03:14SVFEVQQFF0.87410.9591918
KAT6B-CCDC172chr1076741685chr101181002452862HLA-C07:95SVFEVQQFF0.87140.6411918
KAT6B-CCDC172chr1076741685chr101181002452862HLA-B15:04SVFEVQQFF0.8650.7034918
KAT6B-CCDC172chr1076741685chr101181002452862HLA-C12:16SVFEVQQFF0.8240.9292918
KAT6B-CCDC172chr1076741685chr101181002452862HLA-C12:12SVFEVQQFF0.65780.8809918
KAT6B-CCDC172chr1076741685chr101181002452862HLA-C12:04SVFEVQQFF0.50940.9897918
KAT6B-CCDC172chr1076741685chr101181002452862HLA-C02:06SVFEVQQFF0.50340.8612918
KAT6B-CCDC172chr1076741685chr101181002452862HLA-C06:03SVFEVQQFF0.48790.9887918
KAT6B-CCDC172chr1076741685chr101181002452862HLA-B51:07SVFEVQQFF0.35890.5931918
KAT6B-CCDC172chr1076741685chr101181002452862HLA-B27:14RRKDLSVFEV0.99950.7419414
KAT6B-CCDC172chr1076741685chr101181002452862HLA-B27:03RRKDLSVFEV0.9690.8149414
KAT6B-CCDC172chr1076741685chr101181002452862HLA-C04:01VFEVQQFF0.99850.85341018
KAT6B-CCDC172chr1076741685chr101181002452862HLA-C18:01VFEVQQFF0.99750.85521018
KAT6B-CCDC172chr1076741685chr101181002452862HLA-B15:13SVFEVQQF0.9940.5143917
KAT6B-CCDC172chr1076741685chr101181002452862HLA-C04:04VFEVQQFF0.99030.8511018
KAT6B-CCDC172chr1076741685chr101181002452862HLA-B35:28SVFEVQQF0.96570.8941917
KAT6B-CCDC172chr1076741685chr101181002452862HLA-C03:02LSVFEVQQF0.99860.9552817
KAT6B-CCDC172chr1076741685chr101181002452862HLA-B15:39SVFEVQQFF0.99770.5795918
KAT6B-CCDC172chr1076741685chr101181002452862HLA-B57:10LSVFEVQQF0.99750.9444817
KAT6B-CCDC172chr1076741685chr101181002452862HLA-B57:04LSVFEVQQF0.99740.6025817
KAT6B-CCDC172chr1076741685chr101181002452862HLA-B35:11SVFEVQQFF0.9950.7016918
KAT6B-CCDC172chr1076741685chr101181002452862HLA-B58:06LSVFEVQQF0.99480.6812817
KAT6B-CCDC172chr1076741685chr101181002452862HLA-B57:02LSVFEVQQF0.99310.8296817
KAT6B-CCDC172chr1076741685chr101181002452862HLA-C15:09LSVFEVQQF0.99280.8393817
KAT6B-CCDC172chr1076741685chr101181002452862HLA-B57:04SVFEVQQFF0.9920.544918
KAT6B-CCDC172chr1076741685chr101181002452862HLA-B15:20SVFEVQQFF0.99040.8449918
KAT6B-CCDC172chr1076741685chr101181002452862HLA-C03:02SVFEVQQFF0.98910.9186918
KAT6B-CCDC172chr1076741685chr101181002452862HLA-B35:77SVFEVQQFF0.98590.7558918
KAT6B-CCDC172chr1076741685chr101181002452862HLA-B35:17SVFEVQQFF0.98570.5946918
KAT6B-CCDC172chr1076741685chr101181002452862HLA-B35:30SVFEVQQFF0.98570.5946918
KAT6B-CCDC172chr1076741685chr101181002452862HLA-B35:23SVFEVQQFF0.98520.6925918
KAT6B-CCDC172chr1076741685chr101181002452862HLA-B35:28SVFEVQQFF0.98490.8495918
KAT6B-CCDC172chr1076741685chr101181002452862HLA-B58:06SVFEVQQFF0.98090.5988918
KAT6B-CCDC172chr1076741685chr101181002452862HLA-B35:20SVFEVQQFF0.98050.857918
KAT6B-CCDC172chr1076741685chr101181002452862HLA-C15:09SVFEVQQFF0.98040.8256918
KAT6B-CCDC172chr1076741685chr101181002452862HLA-B57:02SVFEVQQFF0.97890.6775918
KAT6B-CCDC172chr1076741685chr101181002452862HLA-A32:01SVFEVQQFF0.97750.865918
KAT6B-CCDC172chr1076741685chr101181002452862HLA-C03:67SVFEVQQFF0.97650.9686918
KAT6B-CCDC172chr1076741685chr101181002452862HLA-A25:01SVFEVQQFF0.97230.5689918
KAT6B-CCDC172chr1076741685chr101181002452862HLA-C03:04SVFEVQQFF0.97170.9818918
KAT6B-CCDC172chr1076741685chr101181002452862HLA-C03:03SVFEVQQFF0.97170.9818918
KAT6B-CCDC172chr1076741685chr101181002452862HLA-B15:50SVFEVQQFF0.97090.8673918
KAT6B-CCDC172chr1076741685chr101181002452862HLA-B57:10SVFEVQQFF0.96660.9191918
KAT6B-CCDC172chr1076741685chr101181002452862HLA-B15:34SVFEVQQFF0.96510.6845918
KAT6B-CCDC172chr1076741685chr101181002452862HLA-B15:125SVFEVQQFF0.96510.6845918
KAT6B-CCDC172chr1076741685chr101181002452862HLA-B15:33SVFEVQQFF0.96510.6845918
KAT6B-CCDC172chr1076741685chr101181002452862HLA-B15:08SVFEVQQFF0.96470.6396918
KAT6B-CCDC172chr1076741685chr101181002452862HLA-B15:135SVFEVQQFF0.96330.7088918
KAT6B-CCDC172chr1076741685chr101181002452862HLA-B15:27SVFEVQQFF0.96320.6557918
KAT6B-CCDC172chr1076741685chr101181002452862HLA-B15:11SVFEVQQFF0.96280.6328918
KAT6B-CCDC172chr1076741685chr101181002452862HLA-C07:17SVFEVQQFF0.95850.9425918
KAT6B-CCDC172chr1076741685chr101181002452862HLA-B35:43SVFEVQQFF0.95660.6439918
KAT6B-CCDC172chr1076741685chr101181002452862HLA-B15:24SVFEVQQFF0.95350.7994918
KAT6B-CCDC172chr1076741685chr101181002452862HLA-C16:04SVFEVQQFF0.94980.9678918
KAT6B-CCDC172chr1076741685chr101181002452862HLA-B15:35SVFEVQQFF0.94960.6483918
KAT6B-CCDC172chr1076741685chr101181002452862HLA-C03:17SVFEVQQFF0.94860.8811918
KAT6B-CCDC172chr1076741685chr101181002452862HLA-C03:05SVFEVQQFF0.94650.7965918
KAT6B-CCDC172chr1076741685chr101181002452862HLA-C07:22SVFEVQQFF0.93370.6361918
KAT6B-CCDC172chr1076741685chr101181002452862HLA-C15:05SVFEVQQFF0.92690.7771918
KAT6B-CCDC172chr1076741685chr101181002452862HLA-B15:12SVFEVQQFF0.91220.66918
KAT6B-CCDC172chr1076741685chr101181002452862HLA-C15:02SVFEVQQFF0.90710.7578918
KAT6B-CCDC172chr1076741685chr101181002452862HLA-C07:02SVFEVQQFF0.90370.9271918
KAT6B-CCDC172chr1076741685chr101181002452862HLA-C07:01SVFEVQQFF0.86860.6033918
KAT6B-CCDC172chr1076741685chr101181002452862HLA-C04:04SVFEVQQFF0.86420.7118918
KAT6B-CCDC172chr1076741685chr101181002452862HLA-B35:24SVFEVQQFF0.86330.84918
KAT6B-CCDC172chr1076741685chr101181002452862HLA-B48:02SVFEVQQFF0.86320.8493918
KAT6B-CCDC172chr1076741685chr101181002452862HLA-B15:53SVFEVQQFF0.82590.6249918
KAT6B-CCDC172chr1076741685chr101181002452862HLA-C12:02SVFEVQQFF0.78590.9386918
KAT6B-CCDC172chr1076741685chr101181002452862HLA-C03:06SVFEVQQFF0.74830.9794918
KAT6B-CCDC172chr1076741685chr101181002452862HLA-C06:06SVFEVQQFF0.73210.9759918
KAT6B-CCDC172chr1076741685chr101181002452862HLA-C16:02SVFEVQQFF0.7050.9771918
KAT6B-CCDC172chr1076741685chr101181002452862HLA-C12:03SVFEVQQFF0.68550.9651918
KAT6B-CCDC172chr1076741685chr101181002452862HLA-B15:54SVFEVQQFF0.63510.6029918
KAT6B-CCDC172chr1076741685chr101181002452862HLA-B15:73SVFEVQQFF0.58960.6232918
KAT6B-CCDC172chr1076741685chr101181002452862HLA-C02:10SVFEVQQFF0.55330.9136918
KAT6B-CCDC172chr1076741685chr101181002452862HLA-C02:02SVFEVQQFF0.55330.9136918
KAT6B-CCDC172chr1076741685chr101181002452862HLA-C06:08SVFEVQQFF0.55170.9666918
KAT6B-CCDC172chr1076741685chr101181002452862HLA-C06:02SVFEVQQFF0.5360.989918
KAT6B-CCDC172chr1076741685chr101181002452862HLA-C06:17SVFEVQQFF0.5360.989918
KAT6B-CCDC172chr1076741685chr101181002452862HLA-A69:01SVFEVQQFF0.53450.6538918
KAT6B-CCDC172chr1076741685chr101181002452862HLA-B18:04SVFEVQQFF0.38260.9465918
KAT6B-CCDC172chr1076741685chr101181002452862HLA-C02:10LSVFEVQQF0.27240.9448817
KAT6B-CCDC172chr1076741685chr101181002452862HLA-C02:02LSVFEVQQF0.27240.9448817
KAT6B-CCDC172chr1076741685chr101181002452862HLA-B18:07SVFEVQQFF0.25770.8922918
KAT6B-CCDC172chr1076741685chr101181002452862HLA-C17:01SVFEVQQFF0.21520.7244918
KAT6B-CCDC172chr1076741685chr101181002452862HLA-B57:10LSVFEVQQFF0.99950.9036818
KAT6B-CCDC172chr1076741685chr101181002452862HLA-B27:06RRKDLSVFEV0.99940.8433414
KAT6B-CCDC172chr1076741685chr101181002452862HLA-B27:08RRKDLSVFEV0.99930.763414
KAT6B-CCDC172chr1076741685chr101181002452862HLA-B27:10RRKDLSVFEV0.99920.8939414
KAT6B-CCDC172chr1076741685chr101181002452862HLA-B57:04LSVFEVQQFF0.99910.5506818
KAT6B-CCDC172chr1076741685chr101181002452862HLA-B27:09RRKDLSVFEV0.99890.7653414
KAT6B-CCDC172chr1076741685chr101181002452862HLA-B58:06LSVFEVQQFF0.99820.5446818
KAT6B-CCDC172chr1076741685chr101181002452862HLA-B57:02LSVFEVQQFF0.99730.6956818
KAT6B-CCDC172chr1076741685chr101181002452862HLA-A25:01EVQQFFEKSF0.99030.65611222
KAT6B-CCDC172chr1076741685chr101181002452862HLA-B57:10KDLSVFEVQQF0.99940.9556617
KAT6B-CCDC172chr1076741685chr101181002452862HLA-B57:04KDLSVFEVQQF0.99860.7571617
KAT6B-CCDC172chr1076741685chr101181002452862HLA-B57:02KDLSVFEVQQF0.99810.942617
KAT6B-CCDC172chr1076741685chr101181002452862HLA-A25:01DLSVFEVQQFF0.98150.7895718

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Potential FusionNeoAntigen Information of KAT6B-CCDC172 in HLA II

check button Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.

check button Potential FusionNeoAntigen Information
* We used NetMHCIIpan v4.1 (%rank<0.5).
Fusion geneHchrHbpTgeneTchrTbpHLA IIFusionNeoAntigen peptideNeoantigen start (at BP 13)Neoantigen end (at BP 13)

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Fusion breakpoint peptide structures of KAT6B-CCDC172

check button3D structures of the fusion breakpoint peptide of 14AA sequence that have potential fusion neoantigens
* The minimum length of the amino acid sequence in RoseTTAFold is 14AA. Here, we predicted the 14AA fusion protein breakpoint sequence not the fusion neoantigen peptide, which is shorter than 14 AA.
File nameBPseqHgeneTgeneHchrHbpTchrTbpAAlen
4156KDLSVFEVQQFFEKKAT6BCCDC172chr1076741685chr101181002452862

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Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D of KAT6B-CCDC172

check buttonVirtual screening between 25 HLAs (from PDB) and FusionNeoAntigens
* We used Glide to predict the interaction between HLAs and neoantigens.
HLA allelePDB IDFile nameBPseqDocking scoreGlide score
HLA-B14:023BVN4156KDLSVFEVQQFFEK-7.9962-8.1096
HLA-B14:023BVN4156KDLSVFEVQQFFEK-5.70842-6.74372
HLA-B52:013W394156KDLSVFEVQQFFEK-6.83737-6.95077
HLA-B52:013W394156KDLSVFEVQQFFEK-4.4836-5.5189
HLA-A11:014UQ24156KDLSVFEVQQFFEK-10.0067-10.1201
HLA-A11:014UQ24156KDLSVFEVQQFFEK-9.03915-10.0745
HLA-A24:025HGA4156KDLSVFEVQQFFEK-6.56204-6.67544
HLA-A24:025HGA4156KDLSVFEVQQFFEK-5.42271-6.45801
HLA-B44:053DX84156KDLSVFEVQQFFEK-7.85648-8.89178
HLA-B44:053DX84156KDLSVFEVQQFFEK-5.3978-5.5112
HLA-A02:016TDR4156KDLSVFEVQQFFEK-3.37154-4.40684

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Vaccine Design for the FusionNeoAntigens of KAT6B-CCDC172

check button mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-Is.
Fusion geneHchrHbpTchrTbpStart in +/-13AAEnd in +/-13AAFusionNeoAntigen peptide sequenceFusionNeoAntigen RNA sequence
KAT6B-CCDC172chr1076741685chr101181002451018VFEVQQFFGTATTTGAGGTTCAACAGTTTTTT
KAT6B-CCDC172chr1076741685chr101181002451222EVQQFFEKSFGAGGTTCAACAGTTTTTTGAAAAATCCTTC
KAT6B-CCDC172chr1076741685chr10118100245414RRKDLSVFEVCGAAGGAAAGACCTTTCAGTATTTGAGGTT
KAT6B-CCDC172chr1076741685chr10118100245617KDLSVFEVQQFAAAGACCTTTCAGTATTTGAGGTTCAACAGTTT
KAT6B-CCDC172chr1076741685chr10118100245718DLSVFEVQQFFGACCTTTCAGTATTTGAGGTTCAACAGTTTTTT
KAT6B-CCDC172chr1076741685chr10118100245817LSVFEVQQFCTTTCAGTATTTGAGGTTCAACAGTTT
KAT6B-CCDC172chr1076741685chr10118100245818LSVFEVQQFFCTTTCAGTATTTGAGGTTCAACAGTTTTTT
KAT6B-CCDC172chr1076741685chr10118100245917SVFEVQQFTCAGTATTTGAGGTTCAACAGTTT
KAT6B-CCDC172chr1076741685chr10118100245918SVFEVQQFFTCAGTATTTGAGGTTCAACAGTTTTTT

check button mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-IIs.
Fusion geneHchrHbpTchrTbpStart in +/-13AAEnd in +/-13AAFusionNeoAntigen peptideFusionNEoAntigen RNA sequence

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Information of the samples that have these potential fusion neoantigens of KAT6B-CCDC172

check button These samples were reported as having these fusion breakpoints. For individual breakpoints, we checked the open reading frames considering multiple gene isoforms and chose the in-frame fusion genes only. Then, we made fusion protein sequences and predicted the fusion neoantigens. These fusion-positive samples may have these potential fusion neoantigens.
Cancer typeFusion geneHchrHbpHenstTchrTbpTenstSample
BRCAKAT6B-CCDC172chr1076741685ENST00000287239chr10118100245ENST00000333254TCGA-AQ-A04L-01B

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Potential target of CAR-T therapy development for KAT6B-CCDC172

check button Predicted 3D structure. We used RoseTTAFold.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, to provide the retention of the transmembrane domain, we only show the protein feature retention information of those transmembrane features


* Minus value of BPloci means that the break point is located before the CDS.
- In-frame and retained 'Transmembrane'.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

check button Subcellular localization prediction of the transmembrane domain retained fusion proteins
* We used DeepLoc 1.0. The order of the X-axis of the barplot is as follows: Entry_ID, Localization, Type, Nucleus, Cytoplasm, Extracellular, Mitochondrion, Cell_membrane, Endoplasmic_reticulum, Plastid, Golgi.apparatus, Lysosome.Vacuole, Peroxisome. Y-axis is the output score of DeepLoc. Clicking the image will open a new tab with a large image.
HgeneHchrHbpHenstTgeneTchrTbpTenstDeepLoc result

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Related Drugs to KAT6B-CCDC172

check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to KAT6B-CCDC172

check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource