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Center for Computational Systems Medicine
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Fusion Gene and Fusion Protein Summary

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Fusion Amino Acid Sequences (multiple BPs and multiple gene isoforms)

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Fusion Protein Breakpoint Sequences - (for the Screening of the FusionNeoAntigens)

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Potential FusionNeoAntigens in HLA I - (netMHCpan v4.1 + deepHLApan v1.1)

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Potential FusionNeoAntigens in HLA II - (netMHCIIpan v4.1)

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Fusion Breakpoint 14 AA Peptide Structure - (RoseTTAFold)

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Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D - (Glide)

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Vaccine Design for the FusionNeoAntigens (RNA/protein sequences)

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Potential target of CAR-T therapy development

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Information on the samples that have these potential fusion neoantigens

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Fusion Protein Targeting Drugs - (Manual Curation)

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Fusion Protein Related diseases - (Manual Curation)

Fusion Protein:KAT6B-CREBBP

Fusion Gene and Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: KAT6B-CREBBP
FusionPDB ID: 41228
FusionGDB2.0 ID: 41228
HgeneTgene
Gene symbol

KAT6B

CREBBP

Gene ID

23522

1387

Gene namelysine acetyltransferase 6BCREB binding protein
SynonymsGTPTS|MORF|MOZ2|MYST4|ZC2HC6B|qkf|querkopfCBP|KAT3A|MKHK1|RSTS|RSTS1
Cytomap

10q22.2

16p13.3

Type of geneprotein-codingprotein-coding
Descriptionhistone acetyltransferase KAT6BK(lysine) acetyltransferase 6BMOZ, YBF2/SAS3, SAS2 and TIP60 protein 4MOZ-related factorMYST histone acetyltransferase (monocytic leukemia) 4MYST-4histone acetyltransferase MORFhistone acetyltransferase MOZ2histone aCREB-binding proteinhistone lysine acetyltransferase CREBBPprotein-lysine acetyltransferase CREBBP
Modification date2020031320200329
UniProtAcc

Q8WYB5

Main function of 5'-partner protein: FUNCTION: Histone acetyltransferase which may be involved in both positive and negative regulation of transcription. Required for RUNX2-dependent transcriptional activation. May be involved in cerebral cortex development. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. {ECO:0000269|PubMed:10497217, ECO:0000269|PubMed:11965546, ECO:0000269|PubMed:16387653}.

Q92793

Main function of 5'-partner protein: FUNCTION: Acetylates histones, giving a specific tag for transcriptional activation (PubMed:24616510). Also acetylates non-histone proteins, like DDX21, FBL, IRF2, MAFG, NCOA3, POLR1E/PAF53 and FOXO1 (PubMed:10490106, PubMed:11154691, PubMed:12738767, PubMed:12929931, PubMed:9707565, PubMed:24207024, PubMed:28790157, PubMed:30540930). Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-ARNTL/BMAL1 and CLOCK-ARNTL/BMAL1 heterodimers (PubMed:14645221). Acetylates PCNA; acetylation promotes removal of chromatin-bound PCNA and its degradation during nucleotide excision repair (NER) (PubMed:24939902). Acetylates POLR1E/PAF53, leading to decreased association of RNA polymerase I with the rDNA promoter region and coding region (PubMed:24207024). Acetylates DDX21, thereby inhibiting DDX21 helicase activity (PubMed:28790157). Acetylates FBL, preventing methylation of 'Gln-105' of histone H2A (H2AQ104me) (PubMed:30540930). Functions as a transcriptional coactivator for SMAD4 in the TGF-beta signaling pathway (PubMed:25514493). {ECO:0000269|PubMed:10490106, ECO:0000269|PubMed:11154691, ECO:0000269|PubMed:12738767, ECO:0000269|PubMed:12929931, ECO:0000269|PubMed:14645221, ECO:0000269|PubMed:24207024, ECO:0000269|PubMed:24616510, ECO:0000269|PubMed:24939902, ECO:0000269|PubMed:25514493, ECO:0000269|PubMed:28790157, ECO:0000269|PubMed:30540930, ECO:0000269|PubMed:9707565}.
Ensembl transtripts involved in fusion geneENST idsENST00000490365, ENST00000287239, 
ENST00000372711, ENST00000372714, 
ENST00000372724, ENST00000372725, 
ENST00000262367, ENST00000382070, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score23 X 21 X 10=483018 X 30 X 8=4320
# samples 3228
** MAII scorelog2(32/4830*10)=-3.91587937883577
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(28/4320*10)=-3.94753258010586
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Fusion gene context

PubMed: KAT6B [Title/Abstract] AND CREBBP [Title/Abstract] AND fusion [Title/Abstract]

Fusion neoantigen context

PubMed: KAT6B [Title/Abstract] AND CREBBP [Title/Abstract] AND neoantigen [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)KAT6B(76785007)-CREBBP(3900846), # samples:1
KAT6B(76785007)-CREBBP(3901010), # samples:1
KAT6B(76786164)-CREBBP(3902521), # samples:1
CREBBP(3929833)-KAT6B(76788245), # samples:1
CREBBP(3902433)-KAT6B(76522543), # samples:1
Anticipated loss of major functional domain due to fusion event.KAT6B-CREBBP seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
KAT6B-CREBBP seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
KAT6B-CREBBP seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
KAT6B-CREBBP seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
CREBBP-KAT6B seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CREBBP-KAT6B seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
KAT6B-CREBBP seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
KAT6B-CREBBP seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
KAT6B-CREBBP seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
KAT6B-CREBBP seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
KAT6B-CREBBP seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
KAT6B-CREBBP seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
KAT6B-CREBBP seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF.
KAT6B-CREBBP seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
KAT6B-CREBBP seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
CREBBP-KAT6B seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
CREBBP-KAT6B seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
CREBBP-KAT6B seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
CREBBP-KAT6B seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
CREBBP-KAT6B seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
CREBBP-KAT6B seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
CREBBP-KAT6B seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF.
CREBBP-KAT6B seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
CREBBP-KAT6B seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneKAT6B

GO:0016573

histone acetylation

11965546

HgeneKAT6B

GO:0043966

histone H3 acetylation

16387653

HgeneKAT6B

GO:0045892

negative regulation of transcription, DNA-templated

10497217

HgeneKAT6B

GO:0045893

positive regulation of transcription, DNA-templated

10497217|11965546

TgeneCREBBP

GO:0000122

negative regulation of transcription by RNA polymerase II

21539536

TgeneCREBBP

GO:0006355

regulation of transcription, DNA-templated

12169688

TgeneCREBBP

GO:0006473

protein acetylation

15273251|24207024|24939902|28790157|30540930

TgeneCREBBP

GO:0016573

histone acetylation

11742995

TgeneCREBBP

GO:0018076

N-terminal peptidyl-lysine acetylation

12435739

TgeneCREBBP

GO:0034644

cellular response to UV

24939902

TgeneCREBBP

GO:0045893

positive regulation of transcription, DNA-templated

11742995

TgeneCREBBP

GO:1990258

histone glutamine methylation

30540930



check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:76785007/chr16:3900846)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonRetention analysis results of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features, are available here.

check buttonFusion gene breakpoints across KAT6B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CREBBP (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Amino Acid Sequences


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000372725KAT6Bchr1076785007ENST00000262367CREBBPchr1639008461288331393423167941
ENST00000372725KAT6Bchr1076785007ENST00000382070CREBBPchr1639008461028431393423167941
ENST00000372724KAT6Bchr1076785007ENST00000262367CREBBPchr1639008461304633025053330941
ENST00000372724KAT6Bchr1076785007ENST00000382070CREBBPchr1639008461044733025053330941
ENST00000287239KAT6Bchr1076785007ENST00000262367CREBBPchr16390084613897415348041811233
ENST00000287239KAT6Bchr1076785007ENST00000382070CREBBPchr16390084611298415348041811233
ENST00000372714KAT6Bchr1076785007ENST00000262367CREBBPchr1639008461293431903933218941
ENST00000372714KAT6Bchr1076785007ENST00000382070CREBBPchr1639008461033531903933218941
ENST00000372711KAT6Bchr1076785007ENST00000262367CREBBPchr16390084613170342630234541050
ENST00000372711KAT6Bchr1076785007ENST00000382070CREBBPchr16390084610571342630234541050
ENST00000372725KAT6Bchr1076785007+ENST00000262367CREBBPchr163901010-130473139342103823346
ENST00000372725KAT6Bchr1076785007+ENST00000382070CREBBPchr163901010-104483139342102683308
ENST00000372724KAT6Bchr1076785007+ENST00000262367CREBBPchr163901010-132103302505105453346
ENST00000372724KAT6Bchr1076785007+ENST00000382070CREBBPchr163901010-106113302505104313308
ENST00000287239KAT6Bchr1076785007+ENST00000262367CREBBPchr163901010-140614153480113963638
ENST00000287239KAT6Bchr1076785007+ENST00000382070CREBBPchr163901010-114624153480112823600
ENST00000372714KAT6Bchr1076785007+ENST00000262367CREBBPchr163901010-130983190393104333346
ENST00000372714KAT6Bchr1076785007+ENST00000382070CREBBPchr163901010-104993190393103193308
ENST00000372711KAT6Bchr1076785007+ENST00000262367CREBBPchr163901010-133343426302106693455
ENST00000372711KAT6Bchr1076785007+ENST00000382070CREBBPchr163901010-107353426302105553417

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000372725ENST00000262367KAT6Bchr1076785007CREBBPchr1639008460.0025778350.9974222
ENST00000372725ENST00000382070KAT6Bchr1076785007CREBBPchr1639008460.0074739850.99252605
ENST00000372724ENST00000262367KAT6Bchr1076785007CREBBPchr1639008460.0025356510.9974643
ENST00000372724ENST00000382070KAT6Bchr1076785007CREBBPchr1639008460.0071688880.9928311
ENST00000287239ENST00000262367KAT6Bchr1076785007CREBBPchr1639008460.0022369730.99776304
ENST00000287239ENST00000382070KAT6Bchr1076785007CREBBPchr1639008460.0056891350.99431086
ENST00000372714ENST00000262367KAT6Bchr1076785007CREBBPchr1639008460.0026100580.99739
ENST00000372714ENST00000382070KAT6Bchr1076785007CREBBPchr1639008460.007492780.9925073
ENST00000372711ENST00000262367KAT6Bchr1076785007CREBBPchr1639008460.00195010.99804986
ENST00000372711ENST00000382070KAT6Bchr1076785007CREBBPchr1639008460.0054608180.9945392
ENST00000372725ENST00000262367KAT6Bchr1076785007+CREBBPchr163901010-0.0019210890.99807894
ENST00000372725ENST00000382070KAT6Bchr1076785007+CREBBPchr163901010-0.0056745170.99432546
ENST00000372724ENST00000262367KAT6Bchr1076785007+CREBBPchr163901010-0.0022570690.997743
ENST00000372724ENST00000382070KAT6Bchr1076785007+CREBBPchr163901010-0.0062874140.9937126
ENST00000287239ENST00000262367KAT6Bchr1076785007+CREBBPchr163901010-0.0020160010.99798393
ENST00000287239ENST00000382070KAT6Bchr1076785007+CREBBPchr163901010-0.0052475540.9947524
ENST00000372714ENST00000262367KAT6Bchr1076785007+CREBBPchr163901010-0.0020617950.9979382
ENST00000372714ENST00000382070KAT6Bchr1076785007+CREBBPchr163901010-0.0059562280.99404377
ENST00000372711ENST00000262367KAT6Bchr1076785007+CREBBPchr163901010-0.0015922370.9984078
ENST00000372711ENST00000382070KAT6Bchr1076785007+CREBBPchr163901010-0.0046077890.9953922

check button Predicted full-length fusion amino acid sequences. For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among all the predicted ones.

Get the fusion protein sequences from here.

Fusion protein sequence information is available in the fasta format.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

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Fusion Protein Breakpoint Sequences for KAT6B-CREBBP

check button +/-13 AA sequence from the breakpoints of the fusion protein sequences.
HgeneHchrHbpTgeneTchrTbpLength(fusion protein)BP in fusion proteinPeptide
KAT6Bchr1076785007CREBBPchr1639010103139933DNHCFKNADPCRNFGSLFDLENDLPD
KAT6Bchr1076785007CREBBPchr1639010103190933DNHCFKNADPCRNFGSLFDLENDLPD
KAT6Bchr1076785007CREBBPchr1639010103302933DNHCFKNADPCRNFGSLFDLENDLPD
KAT6Bchr1076785007CREBBPchr16390101034261042DNHCFKNADPCRNFGSLFDLENDLPD
KAT6Bchr1076785007CREBBPchr16390101041531225DNHCFKNADPCRNFGSLFDLENDLPD

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Potential FusionNeoAntigen Information of KAT6B-CREBBP in HLA I

check button Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.
KAT6B-CREBBP_76785007_3901010.msa

check button Potential FusionNeoAntigen Information
* We used NetMHCpan v4.1 (%rank<0.5) and deepHLApan v1.1 (immunogenic score>0.5)
Fusion geneHchrHbpTgeneTchrTbpHLA IFusionNeoAntigen peptideBinding scoreImmunogenic scoreNeoantigen start (at BP 13)Neoantigen end (at BP 13)
KAT6B-CREBBPchr1076785007chr1639010104153HLA-C05:09NADPCRNF10.8955614
KAT6B-CREBBPchr1076785007chr1639010104153HLA-C04:10NADPCRNF10.6841614
KAT6B-CREBBPchr1076785007chr1639010104153HLA-C04:07NADPCRNF10.6761614
KAT6B-CREBBPchr1076785007chr1639010104153HLA-C08:15NADPCRNF0.99990.9387614
KAT6B-CREBBPchr1076785007chr1639010104153HLA-B39:10DPCRNFGSL0.35560.8704817
KAT6B-CREBBPchr1076785007chr1639010104153HLA-C08:15NADPCRNFGSL10.9469617
KAT6B-CREBBPchr1076785007chr1639010104153HLA-C04:03NADPCRNF10.7088614
KAT6B-CREBBPchr1076785007chr1639010104153HLA-C05:01NADPCRNF10.8955614
KAT6B-CREBBPchr1076785007chr1639010104153HLA-C04:01NADPCRNF10.6761614
KAT6B-CREBBPchr1076785007chr1639010104153HLA-C08:02NADPCRNF0.99990.9387614
KAT6B-CREBBPchr1076785007chr1639010104153HLA-C08:02NADPCRNFGSL10.9469617

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Potential FusionNeoAntigen Information of KAT6B-CREBBP in HLA II

check button Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.

check button Potential FusionNeoAntigen Information
* We used NetMHCIIpan v4.1 (%rank<0.5).
Fusion geneHchrHbpTgeneTchrTbpHLA IIFusionNeoAntigen peptideNeoantigen start (at BP 13)Neoantigen end (at BP 13)

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Fusion breakpoint peptide structures of KAT6B-CREBBP

check button3D structures of the fusion breakpoint peptide of 14AA sequence that have potential fusion neoantigens
* The minimum length of the amino acid sequence in RoseTTAFold is 14AA. Here, we predicted the 14AA fusion protein breakpoint sequence not the fusion neoantigen peptide, which is shorter than 14 AA.
File nameBPseqHgeneTgeneHchrHbpTchrTbpAAlen
6074NADPCRNFGSLFDLKAT6BCREBBPchr1076785007chr1639010104153

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Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D of KAT6B-CREBBP

check buttonVirtual screening between 25 HLAs (from PDB) and FusionNeoAntigens
* We used Glide to predict the interaction between HLAs and neoantigens.
HLA allelePDB IDFile nameBPseqDocking scoreGlide score
HLA-B14:023BVN6074NADPCRNFGSLFDL-5.47913-5.67113
HLA-B14:023BVN6074NADPCRNFGSLFDL-3.84443-4.60543
HLA-B52:013W396074NADPCRNFGSLFDL-6.76995-6.96195
HLA-B52:013W396074NADPCRNFGSLFDL-5.58751-6.34851
HLA-A11:014UQ26074NADPCRNFGSLFDL-5.74663-6.50763
HLA-A11:014UQ26074NADPCRNFGSLFDL-5.69582-5.88782
HLA-A24:025HGA6074NADPCRNFGSLFDL-8.42283-9.18383
HLA-A24:025HGA6074NADPCRNFGSLFDL-7.2103-7.4023
HLA-B27:056PYJ6074NADPCRNFGSLFDL-7.69112-7.88312
HLA-B44:053DX86074NADPCRNFGSLFDL-5.89348-6.08548
HLA-B44:053DX86074NADPCRNFGSLFDL-3.81554-4.57654
HLA-A02:016TDR6074NADPCRNFGSLFDL-3.68024-4.44124

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Vaccine Design for the FusionNeoAntigens of KAT6B-CREBBP

check button mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-Is.
Fusion geneHchrHbpTchrTbpStart in +/-13AAEnd in +/-13AAFusionNeoAntigen peptide sequenceFusionNeoAntigen RNA sequence
KAT6B-CREBBPchr1076785007chr163901010614NADPCRNFAGAATGCTGACCCTTGTAGAAATT
KAT6B-CREBBPchr1076785007chr163901010617NADPCRNFGSLAGAATGCTGACCCTTGTAGAAATTTTGGATCAT
KAT6B-CREBBPchr1076785007chr163901010817DPCRNFGSLCTGACCCTTGTAGAAATTTTGGATCAT

check button mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-IIs.
Fusion geneHchrHbpTchrTbpStart in +/-13AAEnd in +/-13AAFusionNeoAntigen peptideFusionNEoAntigen RNA sequence

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Information of the samples that have these potential fusion neoantigens of KAT6B-CREBBP

check button These samples were reported as having these fusion breakpoints. For individual breakpoints, we checked the open reading frames considering multiple gene isoforms and chose the in-frame fusion genes only. Then, we made fusion protein sequences and predicted the fusion neoantigens. These fusion-positive samples may have these potential fusion neoantigens.
Cancer typeFusion geneHchrHbpHenstTchrTbpTenstSample
N/AKAT6B-CREBBPchr1076785007ENST00000287239chr163901010ENST00000262367AJ299261

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Potential target of CAR-T therapy development for KAT6B-CREBBP

check button Predicted 3D structure. We used RoseTTAFold.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, to provide the retention of the transmembrane domain, we only show the protein feature retention information of those transmembrane features


* Minus value of BPloci means that the break point is located before the CDS.
- In-frame and retained 'Transmembrane'.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

check button Subcellular localization prediction of the transmembrane domain retained fusion proteins
* We used DeepLoc 1.0. The order of the X-axis of the barplot is as follows: Entry_ID, Localization, Type, Nucleus, Cytoplasm, Extracellular, Mitochondrion, Cell_membrane, Endoplasmic_reticulum, Plastid, Golgi.apparatus, Lysosome.Vacuole, Peroxisome. Y-axis is the output score of DeepLoc. Clicking the image will open a new tab with a large image.
HgeneHchrHbpHenstTgeneTchrTbpTenstDeepLoc result

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Related Drugs to KAT6B-CREBBP

check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to KAT6B-CREBBP

check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneCREBBPC4551859RUBINSTEIN-TAYBI SYNDROME 112CLINGEN;GENOMICS_ENGLAND;UNIPROT
TgeneCREBBPC0035934Rubinstein-Taybi Syndrome6CLINGEN;CTD_human
TgeneCREBBPC0033578Prostatic Neoplasms2CTD_human
TgeneCREBBPC0376358Malignant neoplasm of prostate2CTD_human
TgeneCREBBPC4511003Acute myeloid leukemia with t(8;16)(p11;p13) translocation2ORPHANET
TgeneCREBBPC0005684Malignant neoplasm of urinary bladder1CTD_human
TgeneCREBBPC0005695Bladder Neoplasm1CTD_human
TgeneCREBBPC0007137Squamous cell carcinoma1CTD_human
TgeneCREBBPC0007138Carcinoma, Transitional Cell1CTD_human
TgeneCREBBPC0010606Adenoid Cystic Carcinoma1CTD_human
TgeneCREBBPC0011573Endogenous depression1PSYGENET
TgeneCREBBPC0024301Lymphoma, Follicular1CTD_human
TgeneCREBBPC0036920Sezary Syndrome1CTD_human
TgeneCREBBPC0079745Lymphoma, Large-Cell, Follicular1CTD_human
TgeneCREBBPC0079758Lymphoma, Mixed-Cell, Follicular1CTD_human
TgeneCREBBPC0079765Lymphoma, Small Cleaved-Cell, Follicular1CTD_human
TgeneCREBBPC0149925Small cell carcinoma of lung1CTD_human
TgeneCREBBPC0152013Adenocarcinoma of lung (disorder)1CTD_human
TgeneCREBBPC0279626Squamous cell carcinoma of esophagus1CTD_human
TgeneCREBBPC1862939AMYOTROPHIC LATERAL SCLEROSIS 11CTD_human
TgeneCREBBPC1862941Amyotrophic Lateral Sclerosis, Sporadic1CTD_human
TgeneCREBBPC1956130Lymphoma, Follicular, Grade 11CTD_human
TgeneCREBBPC1956131Lymphoma, Follicular, Grade 31CTD_human
TgeneCREBBPC1956132Lymphoma, Follicular, Grade 21CTD_human
TgeneCREBBPC4551993Amyotrophic Lateral Sclerosis, Familial1CTD_human