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Center for Computational Systems Medicine
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Fusion Gene and Fusion Protein Summary

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Fusion Amino Acid Sequences (multiple BPs and multiple gene isoforms)

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Fusion Protein Breakpoint Sequences - (for the Screening of the FusionNeoAntigens)

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Potential FusionNeoAntigens in HLA I - (netMHCpan v4.1 + deepHLApan v1.1)

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Potential FusionNeoAntigens in HLA II - (netMHCIIpan v4.1)

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Fusion Breakpoint 14 AA Peptide Structure - (RoseTTAFold)

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Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D - (Glide)

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Vaccine Design for the FusionNeoAntigens (RNA/protein sequences)

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Potential target of CAR-T therapy development

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Information on the samples that have these potential fusion neoantigens

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Fusion Protein Targeting Drugs - (Manual Curation)

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Fusion Protein Related diseases - (Manual Curation)

Fusion Protein:AMD1-ECHDC1

Fusion Gene and Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: AMD1-ECHDC1
FusionPDB ID: 4190
FusionGDB2.0 ID: 4190
HgeneTgene
Gene symbol

AMD1

ECHDC1

Gene ID

262

55862

Gene nameadenosylmethionine decarboxylase 1ethylmalonyl-CoA decarboxylase 1
SynonymsADOMETDC|AMD|SAMDCHEL-S-76|MMCD|dJ351K20.2
Cytomap

6q21

6q22.33

Type of geneprotein-codingprotein-coding
DescriptionS-adenosylmethionine decarboxylase proenzymeS-adenosylmethionine decarboxylase 1ethylmalonyl-CoA decarboxylaseenoyl CoA hydratase domain containing 1enoyl Coenzyme A hydratase domain containing 1enoyl-CoA hydratase domain-containing protein 1epididymis secretory protein Li 76methylmalonyl-CoA decarboxylase
Modification date2020031320200313
UniProtAcc

P17707

Main function of 5'-partner protein: FUNCTION: Essential for biosynthesis of the polyamines spermidine and spermine. Promotes maintenance and self-renewal of embryonic stem cells, by maintaining spermine levels. {ECO:0000250|UniProtKB:P0DMN7}.

Q9NTX5

Main function of 5'-partner protein: FUNCTION: Decarboxylates ethylmalonyl-CoA, a potentially toxic metabolite, to form butyryl-CoA, suggesting it might be involved in metabolite proofreading (PubMed:22016388). Also has methylmalonyl-CoA decarboxylase activity at lower level (By similarity). {ECO:0000250|UniProtKB:Q9D9V3, ECO:0000269|PubMed:22016388}.
Ensembl transtripts involved in fusion geneENST idsENST00000368877, ENST00000368885, 
ENST00000451850, ENST00000368882, 
ENST00000368876, 
ENST00000488087, 
ENST00000309620, ENST00000368289, 
ENST00000368291, ENST00000430841, 
ENST00000454591, ENST00000454859, 
ENST00000474289, ENST00000528402, 
ENST00000531967, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score15 X 13 X 4=7808 X 7 X 6=336
# samples 1511
** MAII scorelog2(15/780*10)=-2.37851162325373
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(11/336*10)=-1.6109577092541
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Fusion gene context

PubMed: AMD1 [Title/Abstract] AND ECHDC1 [Title/Abstract] AND fusion [Title/Abstract]

Fusion neoantigen context

PubMed: AMD1 [Title/Abstract] AND ECHDC1 [Title/Abstract] AND neoantigen [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)AMD1(111196418)-ECHDC1(127636043), # samples:1
Anticipated loss of major functional domain due to fusion event.AMD1-ECHDC1 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
AMD1-ECHDC1 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr6:111196418/chr6:127636043)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonRetention analysis results of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features, are available here.

check buttonFusion gene breakpoints across AMD1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ECHDC1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Amino Acid Sequences


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000368885AMD1chr6111196418+ENST00000454859ECHDC1chr6127636043-2095446294935213
ENST00000368885AMD1chr6111196418+ENST00000474289ECHDC1chr6127636043-2085446294935213
ENST00000368885AMD1chr6111196418+ENST00000454591ECHDC1chr6127636043-1538446294935213
ENST00000368885AMD1chr6111196418+ENST00000430841ECHDC1chr6127636043-936446294935213
ENST00000368885AMD1chr6111196418+ENST00000531967ECHDC1chr6127636043-2093446294935213
ENST00000451850AMD1chr6111196418+ENST00000454859ECHDC1chr6127636043-2081432280921213
ENST00000451850AMD1chr6111196418+ENST00000474289ECHDC1chr6127636043-2071432280921213
ENST00000451850AMD1chr6111196418+ENST00000454591ECHDC1chr6127636043-1524432280921213
ENST00000451850AMD1chr6111196418+ENST00000430841ECHDC1chr6127636043-922432280921214
ENST00000451850AMD1chr6111196418+ENST00000531967ECHDC1chr6127636043-2079432280921213
ENST00000368877AMD1chr6111196418+ENST00000454859ECHDC1chr6127636043-2080431279920213
ENST00000368877AMD1chr6111196418+ENST00000474289ECHDC1chr6127636043-2070431279920213
ENST00000368877AMD1chr6111196418+ENST00000454591ECHDC1chr6127636043-1523431279920213
ENST00000368877AMD1chr6111196418+ENST00000430841ECHDC1chr6127636043-921431279920213
ENST00000368877AMD1chr6111196418+ENST00000531967ECHDC1chr6127636043-2078431279920213

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000368885ENST00000454859AMD1chr6111196418+ECHDC1chr6127636043-0.0027035270.9972965
ENST00000368885ENST00000474289AMD1chr6111196418+ECHDC1chr6127636043-0.0027847590.9972153
ENST00000368885ENST00000454591AMD1chr6111196418+ECHDC1chr6127636043-0.0043921350.9956079
ENST00000368885ENST00000430841AMD1chr6111196418+ECHDC1chr6127636043-0.0066083930.99339163
ENST00000368885ENST00000531967AMD1chr6111196418+ECHDC1chr6127636043-0.0027336810.9972663
ENST00000451850ENST00000454859AMD1chr6111196418+ECHDC1chr6127636043-0.0025227810.99747723
ENST00000451850ENST00000474289AMD1chr6111196418+ECHDC1chr6127636043-0.00257090.9974291
ENST00000451850ENST00000454591AMD1chr6111196418+ECHDC1chr6127636043-0.003729590.9962704
ENST00000451850ENST00000430841AMD1chr6111196418+ECHDC1chr6127636043-0.006146420.99385357
ENST00000451850ENST00000531967AMD1chr6111196418+ECHDC1chr6127636043-0.0025485190.9974515
ENST00000368877ENST00000454859AMD1chr6111196418+ECHDC1chr6127636043-0.0027239030.9972761
ENST00000368877ENST00000474289AMD1chr6111196418+ECHDC1chr6127636043-0.0028139490.997186
ENST00000368877ENST00000454591AMD1chr6111196418+ECHDC1chr6127636043-0.0038548910.9961451
ENST00000368877ENST00000430841AMD1chr6111196418+ECHDC1chr6127636043-0.0063866750.9936133
ENST00000368877ENST00000531967AMD1chr6111196418+ECHDC1chr6127636043-0.0027845480.9972154

check button Predicted full-length fusion amino acid sequences. For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among all the predicted ones.

Get the fusion protein sequences from here.

Fusion protein sequence information is available in the fasta format.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

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Fusion Protein Breakpoint Sequences for AMD1-ECHDC1

check button +/-13 AA sequence from the breakpoints of the fusion protein sequences.
HgeneHchrHbpTgeneTchrTbpLength(fusion protein)BP in fusion proteinPeptide
AMD1chr6111196418ECHDC1chr612763604343148QPDANQGSGDLRTIPRLPLISVALVQ
AMD1chr6111196418ECHDC1chr612763604343248QPDANQGSGDLRTIPRLPLISVALVQ
AMD1chr6111196418ECHDC1chr612763604344648QPDANQGSGDLRTIPRLPLISVALVQ

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Potential FusionNeoAntigen Information of AMD1-ECHDC1 in HLA I

check button Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.
AMD1-ECHDC1_111196418_127636043.msa

check button Potential FusionNeoAntigen Information
* We used NetMHCpan v4.1 (%rank<0.5) and deepHLApan v1.1 (immunogenic score>0.5)
Fusion geneHchrHbpTgeneTchrTbpHLA IFusionNeoAntigen peptideBinding scoreImmunogenic scoreNeoantigen start (at BP 13)Neoantigen end (at BP 13)
AMD1-ECHDC1chr6111196418chr6127636043431HLA-B27:04LRTIPRLPL0.99960.76111019
AMD1-ECHDC1chr6111196418chr6127636043431HLA-B27:07LRTIPRLPL0.99920.51661019
AMD1-ECHDC1chr6111196418chr6127636043431HLA-B57:01RTIPRLPLI0.99870.98131120
AMD1-ECHDC1chr6111196418chr6127636043431HLA-B58:02RTIPRLPLI0.99820.95631120
AMD1-ECHDC1chr6111196418chr6127636043431HLA-B58:01RTIPRLPLI0.9980.95271120
AMD1-ECHDC1chr6111196418chr6127636043431HLA-B57:03RTIPRLPLI0.99770.98581120
AMD1-ECHDC1chr6111196418chr6127636043431HLA-B15:16RTIPRLPLI0.99640.83871120
AMD1-ECHDC1chr6111196418chr6127636043431HLA-A32:13RTIPRLPLI0.99630.85061120
AMD1-ECHDC1chr6111196418chr6127636043431HLA-B15:17RTIPRLPLI0.99620.941120
AMD1-ECHDC1chr6111196418chr6127636043431HLA-A30:08RTIPRLPLI0.99390.75291120
AMD1-ECHDC1chr6111196418chr6127636043431HLA-B39:24LRTIPRLPL0.99390.55191019
AMD1-ECHDC1chr6111196418chr6127636043431HLA-B14:02LRTIPRLPL0.99230.74991019
AMD1-ECHDC1chr6111196418chr6127636043431HLA-B14:01LRTIPRLPL0.99230.74991019
AMD1-ECHDC1chr6111196418chr6127636043431HLA-A02:21RTIPRLPLI0.95370.59971120
AMD1-ECHDC1chr6111196418chr6127636043431HLA-A02:38RTIPRLPLI0.95110.64361120
AMD1-ECHDC1chr6111196418chr6127636043431HLA-A02:04RTIPRLPLI0.95010.53971120
AMD1-ECHDC1chr6111196418chr6127636043431HLA-A02:13RTIPRLPLI0.89950.57711120
AMD1-ECHDC1chr6111196418chr6127636043431HLA-B13:02RTIPRLPLI0.85730.73571120
AMD1-ECHDC1chr6111196418chr6127636043431HLA-B13:01RTIPRLPLI0.62050.97461120
AMD1-ECHDC1chr6111196418chr6127636043431HLA-B52:01RTIPRLPLI0.54140.89891120
AMD1-ECHDC1chr6111196418chr6127636043431HLA-A30:08RTIPRLPLISV0.99820.82431122
AMD1-ECHDC1chr6111196418chr6127636043431HLA-A02:35RTIPRLPLISV0.94520.66731122
AMD1-ECHDC1chr6111196418chr6127636043431HLA-A02:21RTIPRLPLISV0.9420.73351122
AMD1-ECHDC1chr6111196418chr6127636043431HLA-A02:20RTIPRLPLISV0.90880.63031122
AMD1-ECHDC1chr6111196418chr6127636043431HLA-C15:06RTIPRLPL0.99990.92121119
AMD1-ECHDC1chr6111196418chr6127636043431HLA-C03:08RTIPRLPL0.99930.94331119
AMD1-ECHDC1chr6111196418chr6127636043431HLA-C15:04RTIPRLPLI0.99970.89491120
AMD1-ECHDC1chr6111196418chr6127636043431HLA-C15:06RTIPRLPLI0.99950.93351120
AMD1-ECHDC1chr6111196418chr6127636043431HLA-C03:07RTIPRLPLI0.99830.97411120
AMD1-ECHDC1chr6111196418chr6127636043431HLA-C04:06RTIPRLPLI0.99760.85961120
AMD1-ECHDC1chr6111196418chr6127636043431HLA-C07:05LRTIPRLPL0.9940.9731019
AMD1-ECHDC1chr6111196418chr6127636043431HLA-C03:08RTIPRLPLI0.99160.92871120
AMD1-ECHDC1chr6111196418chr6127636043431HLA-B39:12LRTIPRLPL0.98910.9471019
AMD1-ECHDC1chr6111196418chr6127636043431HLA-C07:29LRTIPRLPL0.97060.96151019
AMD1-ECHDC1chr6111196418chr6127636043431HLA-C02:06RTIPRLPLI0.96720.90521120
AMD1-ECHDC1chr6111196418chr6127636043431HLA-C07:13LRTIPRLPL0.95490.89121019
AMD1-ECHDC1chr6111196418chr6127636043431HLA-C07:46LRTIPRLPL0.95230.91441019
AMD1-ECHDC1chr6111196418chr6127636043431HLA-C12:04RTIPRLPLI0.93450.98971120
AMD1-ECHDC1chr6111196418chr6127636043431HLA-C06:03RTIPRLPLI0.92520.99091120
AMD1-ECHDC1chr6111196418chr6127636043431HLA-C12:12RTIPRLPLI0.80920.93641120
AMD1-ECHDC1chr6111196418chr6127636043431HLA-B14:03LRTIPRLPL0.68270.72641019
AMD1-ECHDC1chr6111196418chr6127636043431HLA-A02:07TIPRLPLISV0.87850.63341222
AMD1-ECHDC1chr6111196418chr6127636043431HLA-C15:06RTIPRLPLISV0.99970.95241122
AMD1-ECHDC1chr6111196418chr6127636043431HLA-B73:01TIPRLPLISVA0.97270.73051223
AMD1-ECHDC1chr6111196418chr6127636043431HLA-A02:05RTIPRLPLISV0.96660.52651122
AMD1-ECHDC1chr6111196418chr6127636043431HLA-B42:02RTIPRLPLISV0.94550.53781122
AMD1-ECHDC1chr6111196418chr6127636043431HLA-B42:01RTIPRLPLISV0.92360.53421122
AMD1-ECHDC1chr6111196418chr6127636043431HLA-C15:05RTIPRLPL0.99990.91131119
AMD1-ECHDC1chr6111196418chr6127636043431HLA-C15:02RTIPRLPL0.99990.85031119
AMD1-ECHDC1chr6111196418chr6127636043431HLA-C03:05RTIPRLPL0.99940.95011119
AMD1-ECHDC1chr6111196418chr6127636043431HLA-C03:17RTIPRLPL0.99920.9851119
AMD1-ECHDC1chr6111196418chr6127636043431HLA-C15:09RTIPRLPLI0.99970.89491120
AMD1-ECHDC1chr6111196418chr6127636043431HLA-B27:08LRTIPRLPL0.99960.8351019
AMD1-ECHDC1chr6111196418chr6127636043431HLA-C15:02RTIPRLPLI0.99960.86111120
AMD1-ECHDC1chr6111196418chr6127636043431HLA-C15:05RTIPRLPLI0.99950.91241120
AMD1-ECHDC1chr6111196418chr6127636043431HLA-B27:06LRTIPRLPL0.99950.77051019
AMD1-ECHDC1chr6111196418chr6127636043431HLA-B27:09LRTIPRLPL0.99940.92521019
AMD1-ECHDC1chr6111196418chr6127636043431HLA-A32:01RTIPRLPLI0.99880.93361120
AMD1-ECHDC1chr6111196418chr6127636043431HLA-B57:10RTIPRLPLI0.99870.98131120
AMD1-ECHDC1chr6111196418chr6127636043431HLA-B58:06RTIPRLPLI0.99820.93061120
AMD1-ECHDC1chr6111196418chr6127636043431HLA-B57:04RTIPRLPLI0.99790.71531120
AMD1-ECHDC1chr6111196418chr6127636043431HLA-B57:02RTIPRLPLI0.99570.84221120
AMD1-ECHDC1chr6111196418chr6127636043431HLA-A30:01RTIPRLPLI0.99410.85661120
AMD1-ECHDC1chr6111196418chr6127636043431HLA-C07:01RTIPRLPLI0.99370.67661120
AMD1-ECHDC1chr6111196418chr6127636043431HLA-C06:06RTIPRLPLI0.98960.98611120
AMD1-ECHDC1chr6111196418chr6127636043431HLA-B39:31LRTIPRLPL0.98810.94441019
AMD1-ECHDC1chr6111196418chr6127636043431HLA-C03:17RTIPRLPLI0.98720.97861120
AMD1-ECHDC1chr6111196418chr6127636043431HLA-C16:02RTIPRLPLI0.98440.98471120
AMD1-ECHDC1chr6111196418chr6127636043431HLA-C16:04RTIPRLPLI0.97990.9641120
AMD1-ECHDC1chr6111196418chr6127636043431HLA-C16:01RTIPRLPLI0.9750.97041120
AMD1-ECHDC1chr6111196418chr6127636043431HLA-A02:14RTIPRLPLI0.95550.50591120
AMD1-ECHDC1chr6111196418chr6127636043431HLA-A02:06RTIPRLPLI0.95370.59971120
AMD1-ECHDC1chr6111196418chr6127636043431HLA-C02:02RTIPRLPLI0.95120.9691120
AMD1-ECHDC1chr6111196418chr6127636043431HLA-C02:10RTIPRLPLI0.95120.9691120
AMD1-ECHDC1chr6111196418chr6127636043431HLA-C06:08RTIPRLPLI0.95120.9841120
AMD1-ECHDC1chr6111196418chr6127636043431HLA-C06:17RTIPRLPLI0.94680.98961120
AMD1-ECHDC1chr6111196418chr6127636043431HLA-C06:02RTIPRLPLI0.94680.98961120
AMD1-ECHDC1chr6111196418chr6127636043431HLA-A69:01RTIPRLPLI0.90610.6871120
AMD1-ECHDC1chr6111196418chr6127636043431HLA-C12:03RTIPRLPLI0.89110.97411120
AMD1-ECHDC1chr6111196418chr6127636043431HLA-C17:01RTIPRLPLI0.84030.90411120
AMD1-ECHDC1chr6111196418chr6127636043431HLA-C15:02RTIPRLPLISV0.99980.9361122
AMD1-ECHDC1chr6111196418chr6127636043431HLA-C15:05RTIPRLPLISV0.99970.96251122
AMD1-ECHDC1chr6111196418chr6127636043431HLA-A30:01RTIPRLPLISV0.99820.92291122
AMD1-ECHDC1chr6111196418chr6127636043431HLA-A32:01RTIPRLPLISV0.99420.96971122
AMD1-ECHDC1chr6111196418chr6127636043431HLA-A68:02RTIPRLPLISV0.95150.59591122
AMD1-ECHDC1chr6111196418chr6127636043431HLA-A02:14RTIPRLPLISV0.9440.68611122
AMD1-ECHDC1chr6111196418chr6127636043431HLA-A02:06RTIPRLPLISV0.9420.73351122
AMD1-ECHDC1chr6111196418chr6127636043431HLA-A69:01RTIPRLPLISV0.92080.77331122

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Potential FusionNeoAntigen Information of AMD1-ECHDC1 in HLA II

check button Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.
AMD1-ECHDC1_111196418_127636043.msa

check button Potential FusionNeoAntigen Information
* We used NetMHCIIpan v4.1 (%rank<0.5).
Fusion geneHchrHbpTgeneTchrTbpHLA IIFusionNeoAntigen peptideNeoantigen start (at BP 13)Neoantigen end (at BP 13)
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-0812SGDLRTIPRLPLISV722
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-0812GSGDLRTIPRLPLIS621
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1102SGDLRTIPRLPLISV722
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1113SGDLRTIPRLPLISV722
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1113GSGDLRTIPRLPLIS621
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1113QGSGDLRTIPRLPLI520
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1116SGDLRTIPRLPLISV722
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1117GSGDLRTIPRLPLIS621
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1117SGDLRTIPRLPLISV722
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1117QGSGDLRTIPRLPLI520
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1118SGDLRTIPRLPLISV722
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1118GSGDLRTIPRLPLIS621
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1121SGDLRTIPRLPLISV722
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1121GSGDLRTIPRLPLIS621
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1134SGDLRTIPRLPLISV722
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1134GSGDLRTIPRLPLIS621
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1136SGDLRTIPRLPLISV722
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1141SGDLRTIPRLPLISV722
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1142SGDLRTIPRLPLISV722
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1142GSGDLRTIPRLPLIS621
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1148SGDLRTIPRLPLISV722
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1148GSGDLRTIPRLPLIS621
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1152GSGDLRTIPRLPLIS621
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1152SGDLRTIPRLPLISV722
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1152QGSGDLRTIPRLPLI520
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1154SGDLRTIPRLPLISV722
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1154GSGDLRTIPRLPLIS621
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1157SGDLRTIPRLPLISV722
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1157GSGDLRTIPRLPLIS621
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1159SGDLRTIPRLPLISV722
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1159GSGDLRTIPRLPLIS621
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1165SGDLRTIPRLPLISV722
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1184SGDLRTIPRLPLISV722
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1184GSGDLRTIPRLPLIS621
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1189SGDLRTIPRLPLISV722
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1189GSGDLRTIPRLPLIS621
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1189QGSGDLRTIPRLPLI520
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1192SGDLRTIPRLPLISV722
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1192GSGDLRTIPRLPLIS621
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1204SGDLRTIPRLPLISV722
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1204GSGDLRTIPRLPLIS621
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1208SGDLRTIPRLPLISV722
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1208GSGDLRTIPRLPLIS621
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1209SGDLRTIPRLPLISV722
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1209GSGDLRTIPRLPLIS621
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1220SGDLRTIPRLPLISV722
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1220GSGDLRTIPRLPLIS621
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1301SGDLRTIPRLPLISV722
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1304SGDLRTIPRLPLISV722
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1304GSGDLRTIPRLPLIS621
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1306SGDLRTIPRLPLISV722
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1306GSGDLRTIPRLPLIS621
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1308SGDLRTIPRLPLISV722
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1308GSGDLRTIPRLPLIS621
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1309SGDLRTIPRLPLISV722
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1309GSGDLRTIPRLPLIS621
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-13100GSGDLRTIPRLPLIS621
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-13100SGDLRTIPRLPLISV722
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1319SGDLRTIPRLPLISV722
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1320SGDLRTIPRLPLISV722
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1322SGDLRTIPRLPLISV722
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1327SGDLRTIPRLPLISV722
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1327GSGDLRTIPRLPLIS621
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1331SGDLRTIPRLPLISV722
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1331GSGDLRTIPRLPLIS621
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1332GSGDLRTIPRLPLIS621
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1332SGDLRTIPRLPLISV722
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1335SGDLRTIPRLPLISV722
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1343SGDLRTIPRLPLISV722
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1343GSGDLRTIPRLPLIS621
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1343QGSGDLRTIPRLPLI520
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1344SGDLRTIPRLPLISV722
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1344GSGDLRTIPRLPLIS621
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1346GSGDLRTIPRLPLIS621
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1346SGDLRTIPRLPLISV722
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1348GSGDLRTIPRLPLIS621
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1348SGDLRTIPRLPLISV722
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1351SGDLRTIPRLPLISV722
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1352SGDLRTIPRLPLISV722
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1353SGDLRTIPRLPLISV722
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1354SGDLRTIPRLPLISV722
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1354GSGDLRTIPRLPLIS621
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1354QGSGDLRTIPRLPLI520
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1358GSGDLRTIPRLPLIS621
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1358SGDLRTIPRLPLISV722
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1359SGDLRTIPRLPLISV722
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1361SGDLRTIPRLPLISV722
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1364SGDLRTIPRLPLISV722
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1368SGDLRTIPRLPLISV722
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1369SGDLRTIPRLPLISV722
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1370SGDLRTIPRLPLISV722
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1370GSGDLRTIPRLPLIS621
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1371SGDLRTIPRLPLISV722
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1371GSGDLRTIPRLPLIS621
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1372SGDLRTIPRLPLISV722
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1372GSGDLRTIPRLPLIS621
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1375SGDLRTIPRLPLISV722
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1375GSGDLRTIPRLPLIS621
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1376SGDLRTIPRLPLISV722
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1376GSGDLRTIPRLPLIS621
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1377SGDLRTIPRLPLISV722
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1377GSGDLRTIPRLPLIS621
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1377QGSGDLRTIPRLPLI520
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1377GDLRTIPRLPLISVA823
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1378SGDLRTIPRLPLISV722
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1379SGDLRTIPRLPLISV722
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1380SGDLRTIPRLPLISV722
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1381GSGDLRTIPRLPLIS621
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1381SGDLRTIPRLPLISV722
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1383SGDLRTIPRLPLISV722
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1384SGDLRTIPRLPLISV722
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1384GSGDLRTIPRLPLIS621
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1387SGDLRTIPRLPLISV722
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1389GSGDLRTIPRLPLIS621
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1389SGDLRTIPRLPLISV722
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1391SGDLRTIPRLPLISV722
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1392SGDLRTIPRLPLISV722
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1393SGDLRTIPRLPLISV722
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1393GSGDLRTIPRLPLIS621
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1394GSGDLRTIPRLPLIS621
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1394SGDLRTIPRLPLISV722
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1398SGDLRTIPRLPLISV722
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1398GSGDLRTIPRLPLIS621
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1401GSGDLRTIPRLPLIS621
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1401SGDLRTIPRLPLISV722
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1401QGSGDLRTIPRLPLI520
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1401GDLRTIPRLPLISVA823
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1401NQGSGDLRTIPRLPL419
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1404GSGDLRTIPRLPLIS621
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1404SGDLRTIPRLPLISV722
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1404QGSGDLRTIPRLPLI520
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1404GDLRTIPRLPLISVA823
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1405GSGDLRTIPRLPLIS621
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1405SGDLRTIPRLPLISV722
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1405QGSGDLRTIPRLPLI520
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1406SGDLRTIPRLPLISV722
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1406GSGDLRTIPRLPLIS621
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1407GSGDLRTIPRLPLIS621
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1407SGDLRTIPRLPLISV722
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1407QGSGDLRTIPRLPLI520
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1408GSGDLRTIPRLPLIS621
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1408SGDLRTIPRLPLISV722
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1408QGSGDLRTIPRLPLI520
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1411GSGDLRTIPRLPLIS621
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1411SGDLRTIPRLPLISV722
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1411QGSGDLRTIPRLPLI520
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1412SGDLRTIPRLPLISV722
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1412GSGDLRTIPRLPLIS621
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1414SGDLRTIPRLPLISV722
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1416SGDLRTIPRLPLISV722
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1416GSGDLRTIPRLPLIS621
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1416QGSGDLRTIPRLPLI520
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1417SGDLRTIPRLPLISV722
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1417GSGDLRTIPRLPLIS621
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1418SGDLRTIPRLPLISV722
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1418GSGDLRTIPRLPLIS621
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1418QGSGDLRTIPRLPLI520
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1420SGDLRTIPRLPLISV722
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1420GSGDLRTIPRLPLIS621
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1421SGDLRTIPRLPLISV722
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1421GSGDLRTIPRLPLIS621
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1423GSGDLRTIPRLPLIS621
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1423SGDLRTIPRLPLISV722
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1423QGSGDLRTIPRLPLI520
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1426GSGDLRTIPRLPLIS621
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1426SGDLRTIPRLPLISV722
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1426QGSGDLRTIPRLPLI520
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1426GDLRTIPRLPLISVA823
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1426NQGSGDLRTIPRLPL419
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1428GSGDLRTIPRLPLIS621
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1428SGDLRTIPRLPLISV722
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1428QGSGDLRTIPRLPLI520
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1428GDLRTIPRLPLISVA823
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1428NQGSGDLRTIPRLPL419
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1429SGDLRTIPRLPLISV722
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1429GSGDLRTIPRLPLIS621
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1431GSGDLRTIPRLPLIS621
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1431SGDLRTIPRLPLISV722
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1431QGSGDLRTIPRLPLI520
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1432GSGDLRTIPRLPLIS621
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1432SGDLRTIPRLPLISV722
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1432QGSGDLRTIPRLPLI520
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1432GDLRTIPRLPLISVA823
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1433SGDLRTIPRLPLISV722
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1433GSGDLRTIPRLPLIS621
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1433QGSGDLRTIPRLPLI520
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1434SGDLRTIPRLPLISV722
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1434GSGDLRTIPRLPLIS621
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1434QGSGDLRTIPRLPLI520
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1435GSGDLRTIPRLPLIS621
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1435SGDLRTIPRLPLISV722
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1435QGSGDLRTIPRLPLI520
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1435GDLRTIPRLPLISVA823
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1435NQGSGDLRTIPRLPL419
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1436SGDLRTIPRLPLISV722
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1437SGDLRTIPRLPLISV722
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1437GSGDLRTIPRLPLIS621
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1438SGDLRTIPRLPLISV722
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1438GSGDLRTIPRLPLIS621
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1438QGSGDLRTIPRLPLI520
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1438GDLRTIPRLPLISVA823
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1439GSGDLRTIPRLPLIS621
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1439SGDLRTIPRLPLISV722
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1439QGSGDLRTIPRLPLI520
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1442SGDLRTIPRLPLISV722
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1442GSGDLRTIPRLPLIS621
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1443SGDLRTIPRLPLISV722
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1443GSGDLRTIPRLPLIS621
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1443QGSGDLRTIPRLPLI520
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1444SGDLRTIPRLPLISV722
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1445SGDLRTIPRLPLISV722
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1445GSGDLRTIPRLPLIS621
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1445QGSGDLRTIPRLPLI520
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1445GDLRTIPRLPLISVA823
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1449SGDLRTIPRLPLISV722
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1449GSGDLRTIPRLPLIS621
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1450GSGDLRTIPRLPLIS621
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1450SGDLRTIPRLPLISV722
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1450QGSGDLRTIPRLPLI520
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1452SGDLRTIPRLPLISV722
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1452GSGDLRTIPRLPLIS621
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1454GSGDLRTIPRLPLIS621
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1454SGDLRTIPRLPLISV722
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1454QGSGDLRTIPRLPLI520
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1454GDLRTIPRLPLISVA823
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1454NQGSGDLRTIPRLPL419
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1455SGDLRTIPRLPLISV722
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1455GSGDLRTIPRLPLIS621
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1455QGSGDLRTIPRLPLI520
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1455GDLRTIPRLPLISVA823
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1456GSGDLRTIPRLPLIS621
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1456SGDLRTIPRLPLISV722
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1456QGSGDLRTIPRLPLI520
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1458GSGDLRTIPRLPLIS621
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1458SGDLRTIPRLPLISV722
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1458QGSGDLRTIPRLPLI520
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1458GDLRTIPRLPLISVA823
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1458NQGSGDLRTIPRLPL419
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1459GSGDLRTIPRLPLIS621
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1459SGDLRTIPRLPLISV722
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1459QGSGDLRTIPRLPLI520
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1460GSGDLRTIPRLPLIS621
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1460SGDLRTIPRLPLISV722
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1460QGSGDLRTIPRLPLI520
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1460GDLRTIPRLPLISVA823
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1460NQGSGDLRTIPRLPL419
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1461GSGDLRTIPRLPLIS621
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1461SGDLRTIPRLPLISV722
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1461QGSGDLRTIPRLPLI520
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1461GDLRTIPRLPLISVA823
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1462GSGDLRTIPRLPLIS621
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1462SGDLRTIPRLPLISV722
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1462QGSGDLRTIPRLPLI520
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1462GDLRTIPRLPLISVA823
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1462NQGSGDLRTIPRLPL419
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1464GSGDLRTIPRLPLIS621
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1464SGDLRTIPRLPLISV722
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1464QGSGDLRTIPRLPLI520
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1464GDLRTIPRLPLISVA823
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1465SGDLRTIPRLPLISV722
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1465GSGDLRTIPRLPLIS621
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1465QGSGDLRTIPRLPLI520
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1465GDLRTIPRLPLISVA823
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1468GSGDLRTIPRLPLIS621
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1468SGDLRTIPRLPLISV722
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1468QGSGDLRTIPRLPLI520
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1470GSGDLRTIPRLPLIS621
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1470SGDLRTIPRLPLISV722
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1470QGSGDLRTIPRLPLI520
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1471GSGDLRTIPRLPLIS621
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1471SGDLRTIPRLPLISV722
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1471QGSGDLRTIPRLPLI520
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1472GSGDLRTIPRLPLIS621
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1472SGDLRTIPRLPLISV722
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1472QGSGDLRTIPRLPLI520
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1472GDLRTIPRLPLISVA823
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1473GSGDLRTIPRLPLIS621
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1473SGDLRTIPRLPLISV722
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1473QGSGDLRTIPRLPLI520
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1474GSGDLRTIPRLPLIS621
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1474SGDLRTIPRLPLISV722
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1474QGSGDLRTIPRLPLI520
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1475GSGDLRTIPRLPLIS621
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1475SGDLRTIPRLPLISV722
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1475QGSGDLRTIPRLPLI520
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1475GDLRTIPRLPLISVA823
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1475NQGSGDLRTIPRLPL419
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1478SGDLRTIPRLPLISV722
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1478GSGDLRTIPRLPLIS621
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1480SGDLRTIPRLPLISV722
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1480GSGDLRTIPRLPLIS621
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1481SGDLRTIPRLPLISV722
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1481GSGDLRTIPRLPLIS621
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1481QGSGDLRTIPRLPLI520
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1482GSGDLRTIPRLPLIS621
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1482SGDLRTIPRLPLISV722
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1482QGSGDLRTIPRLPLI520
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1482GDLRTIPRLPLISVA823
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1482NQGSGDLRTIPRLPL419
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1483SGDLRTIPRLPLISV722
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1483GSGDLRTIPRLPLIS621
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1486GSGDLRTIPRLPLIS621
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1486SGDLRTIPRLPLISV722
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1486QGSGDLRTIPRLPLI520
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1486GDLRTIPRLPLISVA823
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1486NQGSGDLRTIPRLPL419
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1487GSGDLRTIPRLPLIS621
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1487SGDLRTIPRLPLISV722
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1487QGSGDLRTIPRLPLI520
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1487GDLRTIPRLPLISVA823
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1487NQGSGDLRTIPRLPL419
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1488GSGDLRTIPRLPLIS621
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1488SGDLRTIPRLPLISV722
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1488QGSGDLRTIPRLPLI520
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1488GDLRTIPRLPLISVA823
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1488NQGSGDLRTIPRLPL419
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1490GSGDLRTIPRLPLIS621
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1490SGDLRTIPRLPLISV722
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1490QGSGDLRTIPRLPLI520
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1490GDLRTIPRLPLISVA823
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1490NQGSGDLRTIPRLPL419
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1491GSGDLRTIPRLPLIS621
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1491SGDLRTIPRLPLISV722
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1491QGSGDLRTIPRLPLI520
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1495GSGDLRTIPRLPLIS621
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1495SGDLRTIPRLPLISV722
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1495QGSGDLRTIPRLPLI520
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1495GDLRTIPRLPLISVA823
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1496GSGDLRTIPRLPLIS621
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1496SGDLRTIPRLPLISV722
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1496QGSGDLRTIPRLPLI520
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1497GSGDLRTIPRLPLIS621
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1497SGDLRTIPRLPLISV722
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1497QGSGDLRTIPRLPLI520
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1497GDLRTIPRLPLISVA823
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1497NQGSGDLRTIPRLPL419
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1499SGDLRTIPRLPLISV722
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1499GSGDLRTIPRLPLIS621
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1499QGSGDLRTIPRLPLI520
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1499GDLRTIPRLPLISVA823
AMD1-ECHDC1chr6111196418chr6127636043431DRB1-1499NQGSGDLRTIPRLPL419

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Fusion breakpoint peptide structures of AMD1-ECHDC1

check button3D structures of the fusion breakpoint peptide of 14AA sequence that have potential fusion neoantigens
* The minimum length of the amino acid sequence in RoseTTAFold is 14AA. Here, we predicted the 14AA fusion protein breakpoint sequence not the fusion neoantigen peptide, which is shorter than 14 AA.
File nameBPseqHgeneTgeneHchrHbpTchrTbpAAlen
3120GSGDLRTIPRLPLIAMD1ECHDC1chr6111196418chr6127636043431

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Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D of AMD1-ECHDC1

check buttonVirtual screening between 25 HLAs (from PDB) and FusionNeoAntigens
* We used Glide to predict the interaction between HLAs and neoantigens.
HLA allelePDB IDFile nameBPseqDocking scoreGlide score
HLA-B14:023BVN3120GSGDLRTIPRLPLI-7.4838-7.5956
HLA-B14:023BVN3120GSGDLRTIPRLPLI-3.16066-4.20376
HLA-B52:013W393120GSGDLRTIPRLPLI-6.93679-7.04859
HLA-B52:013W393120GSGDLRTIPRLPLI-6.10064-7.14374
HLA-A11:014UQ23120GSGDLRTIPRLPLI-7.21307-7.32487
HLA-A24:025HGA3120GSGDLRTIPRLPLI-6.56769-6.67949
HLA-A24:025HGA3120GSGDLRTIPRLPLI-4.65311-5.69621
HLA-B44:053DX83120GSGDLRTIPRLPLI-6.68002-6.79182
HLA-B44:053DX83120GSGDLRTIPRLPLI-3.22493-4.26803

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Vaccine Design for the FusionNeoAntigens of AMD1-ECHDC1

check button mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-Is.
Fusion geneHchrHbpTchrTbpStart in +/-13AAEnd in +/-13AAFusionNeoAntigen peptide sequenceFusionNeoAntigen RNA sequence
AMD1-ECHDC1chr6111196418chr61276360431019LRTIPRLPLTATCCCAAGACTTCCTTTAATAAGTGT
AMD1-ECHDC1chr6111196418chr61276360431119RTIPRLPLCCCAAGACTTCCTTTAATAAGTGT
AMD1-ECHDC1chr6111196418chr61276360431120RTIPRLPLICCCAAGACTTCCTTTAATAAGTGTTGC
AMD1-ECHDC1chr6111196418chr61276360431122RTIPRLPLISVCCCAAGACTTCCTTTAATAAGTGTTGCGCTGGT
AMD1-ECHDC1chr6111196418chr61276360431222TIPRLPLISVAAGACTTCCTTTAATAAGTGTTGCGCTGGT
AMD1-ECHDC1chr6111196418chr61276360431223TIPRLPLISVAAAGACTTCCTTTAATAAGTGTTGCGCTGGTTCA

check button mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-IIs.
Fusion geneHchrHbpTchrTbpStart in +/-13AAEnd in +/-13AAFusionNeoAntigen peptideFusionNEoAntigen RNA sequence
AMD1-ECHDC1chr6111196418chr6127636043419NQGSGDLRTIPRLPLATCTGGGGATCTTCGCACTATCCCAAGACTTCCTTTAATAAGTGT
AMD1-ECHDC1chr6111196418chr6127636043520QGSGDLRTIPRLPLITGGGGATCTTCGCACTATCCCAAGACTTCCTTTAATAAGTGTTGC
AMD1-ECHDC1chr6111196418chr6127636043621GSGDLRTIPRLPLISGGATCTTCGCACTATCCCAAGACTTCCTTTAATAAGTGTTGCGCT
AMD1-ECHDC1chr6111196418chr6127636043722SGDLRTIPRLPLISVTCTTCGCACTATCCCAAGACTTCCTTTAATAAGTGTTGCGCTGGT
AMD1-ECHDC1chr6111196418chr6127636043823GDLRTIPRLPLISVATCGCACTATCCCAAGACTTCCTTTAATAAGTGTTGCGCTGGTTCA

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Information of the samples that have these potential fusion neoantigens of AMD1-ECHDC1

check button These samples were reported as having these fusion breakpoints. For individual breakpoints, we checked the open reading frames considering multiple gene isoforms and chose the in-frame fusion genes only. Then, we made fusion protein sequences and predicted the fusion neoantigens. These fusion-positive samples may have these potential fusion neoantigens.
Cancer typeFusion geneHchrHbpHenstTchrTbpTenstSample
N/AAMD1-ECHDC1chr6111196418ENST00000368877chr6127636043ENST00000430841CN399561

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Potential target of CAR-T therapy development for AMD1-ECHDC1

check button Predicted 3D structure. We used RoseTTAFold.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, to provide the retention of the transmembrane domain, we only show the protein feature retention information of those transmembrane features


* Minus value of BPloci means that the break point is located before the CDS.
- In-frame and retained 'Transmembrane'.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

check button Subcellular localization prediction of the transmembrane domain retained fusion proteins
* We used DeepLoc 1.0. The order of the X-axis of the barplot is as follows: Entry_ID, Localization, Type, Nucleus, Cytoplasm, Extracellular, Mitochondrion, Cell_membrane, Endoplasmic_reticulum, Plastid, Golgi.apparatus, Lysosome.Vacuole, Peroxisome. Y-axis is the output score of DeepLoc. Clicking the image will open a new tab with a large image.
HgeneHchrHbpHenstTgeneTchrTbpTenstDeepLoc result

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Related Drugs to AMD1-ECHDC1

check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to AMD1-ECHDC1

check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource