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Center for Computational Systems Medicine
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Fusion Gene and Fusion Protein Summary

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Fusion Amino Acid Sequences (multiple BPs and multiple gene isoforms)

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Fusion Protein Breakpoint Sequences - (for the Screening of the FusionNeoAntigens)

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Potential FusionNeoAntigens in HLA I - (netMHCpan v4.1 + deepHLApan v1.1)

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Potential FusionNeoAntigens in HLA II - (netMHCIIpan v4.1)

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Fusion Breakpoint 14 AA Peptide Structure - (RoseTTAFold)

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Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D - (Glide)

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Vaccine Design for the FusionNeoAntigens (RNA/protein sequences)

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Potential target of CAR-T therapy development

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Information on the samples that have these potential fusion neoantigens

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Fusion Protein Targeting Drugs - (Manual Curation)

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Fusion Protein Related diseases - (Manual Curation)

Fusion Protein:KIAA0586-ARID4A

Fusion Gene and Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: KIAA0586-ARID4A
FusionPDB ID: 42154
FusionGDB2.0 ID: 42154
HgeneTgene
Gene symbol

KIAA0586

ARID4A

Gene ID

9786

5926

Gene nameKIAA0586AT-rich interaction domain 4A
SynonymsJBTS23|SRTD14|Talpid3RBBP-1|RBBP1|RBP-1|RBP1
Cytomap

14q23.1

14q23.1

Type of geneprotein-codingprotein-coding
Descriptionprotein TALPID3AT-rich interactive domain-containing protein 4AARID domain-containing protein 4AAT rich interactive domain 4A (RBP1-like)retinoblastoma-binding protein 1
Modification date2020032020200320
UniProtAcc

Q9BVV6

Main function of 5'-partner protein: FUNCTION: Required for ciliogenesis and sonic hedgehog/SHH signaling. Required for the centrosomal recruitment of RAB8A and for the targeting of centriole satellite proteins to centrosomes such as of PCM1. May play a role in early ciliogenesis in the disappearance of centriolar satellites that preceeds ciliary vesicle formation (PubMed:24421332). Involved in regulation of cell intracellular organization. Involved in regulation of cell polarity (By similarity). Required for asymmetrical localization of CEP120 to daughter centrioles (By similarity). {ECO:0000250|UniProtKB:E9PV87, ECO:0000250|UniProtKB:Q1G7G9, ECO:0000269|PubMed:24421332}.

P29374

Main function of 5'-partner protein: FUNCTION: DNA-binding protein which modulates activity of several transcription factors including RB1 (retinoblastoma-associated protein) and AR (androgen receptor) (By similarity). May function as part of an mSin3A repressor complex (PubMed:14581478). Has no intrinsic transcriptional activity (By similarity). Plays a role in the regulation of epigenetic modifications at the PWS/AS imprinting center near the SNRPN promoter, where it might function as part of a complex with RB1 and ARID4B (By similarity). Involved in spermatogenesis, together with ARID4B, where it acts as a transcriptional coactivator for AR and enhances expression of genes required for sperm maturation. Regulates expression of the tight junction protein CLDN3 in the testis, which is important for integrity of the blood-testis barrier (By similarity). Plays a role in myeloid homeostasis where it regulates the histone methylation state of bone marrow cells and expression of various genes involved in hematopoiesis. May function as a leukemia suppressor (By similarity). {ECO:0000250|UniProtKB:F8VPQ2, ECO:0000269|PubMed:14581478}.
Ensembl transtripts involved in fusion geneENST idsENST00000538571, ENST00000261244, 
ENST00000354386, ENST00000423743, 
ENST00000556134, 		ENST00000348476, 
ENST00000355431, ENST00000395168, 
ENST00000431317, ENST00000553355, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score5 X 5 X 4=1005 X 6 X 2=60
# samples 66
** MAII scorelog2(6/100*10)=-0.736965594166206
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/60*10)=0
Fusion gene context

PubMed: KIAA0586 [Title/Abstract] AND ARID4A [Title/Abstract] AND fusion [Title/Abstract]

Fusion neoantigen context

PubMed: KIAA0586 [Title/Abstract] AND ARID4A [Title/Abstract] AND neoantigen [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)ARID4A(58768408)-KIAA0586(59006789), # samples:2
ARID4A(58765418)-KIAA0586(59006789), # samples:2
KIAA0586(58927878)-ARID4A(58813128), # samples:1
KIAA0586(58927878)-ARID4A(58813129), # samples:1
Anticipated loss of major functional domain due to fusion event.KIAA0586-ARID4A seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
KIAA0586-ARID4A seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
KIAA0586-ARID4A seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
KIAA0586-ARID4A seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ARID4A-KIAA0586 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
ARID4A-KIAA0586 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
ARID4A-KIAA0586 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneARID4A

GO:0045892

negative regulation of transcription, DNA-templated

12724404



check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr14:58768408/chr14:59006789)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonRetention analysis results of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features, are available here.

check buttonFusion gene breakpoints across KIAA0586 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ARID4A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Amino Acid Sequences


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000354386KIAA0586chr1458927878+ENST00000355431ARID4Achr1458813128+7001246224452561670
ENST00000354386KIAA0586chr1458927878+ENST00000348476ARID4Achr1458813128+6791246224450491601
ENST00000354386KIAA0586chr1458927878+ENST00000395168ARID4Achr1458813128+5332246224450941616
ENST00000354386KIAA0586chr1458927878+ENST00000431317ARID4Achr1458813128+6948246224450491601
ENST00000556134KIAA0586chr1458927878+ENST00000355431ARID4Achr1458813128+6827228816950821637
ENST00000556134KIAA0586chr1458927878+ENST00000348476ARID4Achr1458813128+6617228816948751568
ENST00000556134KIAA0586chr1458927878+ENST00000395168ARID4Achr1458813128+5158228816949201583
ENST00000556134KIAA0586chr1458927878+ENST00000431317ARID4Achr1458813128+6774228816948751568
ENST00000423743KIAA0586chr1458927878+ENST00000355431ARID4Achr1458813128+6724218513549791614
ENST00000423743KIAA0586chr1458927878+ENST00000348476ARID4Achr1458813128+6514218513547721545
ENST00000423743KIAA0586chr1458927878+ENST00000395168ARID4Achr1458813128+5055218513548171560
ENST00000423743KIAA0586chr1458927878+ENST00000431317ARID4Achr1458813128+6671218513547721545
ENST00000261244KIAA0586chr1458927878+ENST00000355431ARID4Achr1458813128+6645210627549001541
ENST00000261244KIAA0586chr1458927878+ENST00000348476ARID4Achr1458813128+6435210627546931472
ENST00000261244KIAA0586chr1458927878+ENST00000395168ARID4Achr1458813128+4976210627547381487
ENST00000261244KIAA0586chr1458927878+ENST00000431317ARID4Achr1458813128+6592210627546931472
ENST00000354386KIAA0586chr1458927878+ENST00000355431ARID4Achr1458813129+7001246224452561670
ENST00000354386KIAA0586chr1458927878+ENST00000348476ARID4Achr1458813129+6791246224450491601
ENST00000354386KIAA0586chr1458927878+ENST00000395168ARID4Achr1458813129+5332246224450941616
ENST00000354386KIAA0586chr1458927878+ENST00000431317ARID4Achr1458813129+6948246224450491601
ENST00000556134KIAA0586chr1458927878+ENST00000355431ARID4Achr1458813129+6827228816950821637
ENST00000556134KIAA0586chr1458927878+ENST00000348476ARID4Achr1458813129+6617228816948751568
ENST00000556134KIAA0586chr1458927878+ENST00000395168ARID4Achr1458813129+5158228816949201583
ENST00000556134KIAA0586chr1458927878+ENST00000431317ARID4Achr1458813129+6774228816948751568
ENST00000423743KIAA0586chr1458927878+ENST00000355431ARID4Achr1458813129+6724218513549791614
ENST00000423743KIAA0586chr1458927878+ENST00000348476ARID4Achr1458813129+6514218513547721545
ENST00000423743KIAA0586chr1458927878+ENST00000395168ARID4Achr1458813129+5055218513548171560
ENST00000423743KIAA0586chr1458927878+ENST00000431317ARID4Achr1458813129+6671218513547721545
ENST00000261244KIAA0586chr1458927878+ENST00000355431ARID4Achr1458813129+6645210627549001541
ENST00000261244KIAA0586chr1458927878+ENST00000348476ARID4Achr1458813129+6435210627546931472
ENST00000261244KIAA0586chr1458927878+ENST00000395168ARID4Achr1458813129+4976210627547381487
ENST00000261244KIAA0586chr1458927878+ENST00000431317ARID4Achr1458813129+6592210627546931472

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000354386ENST00000355431KIAA0586chr1458927878+ARID4Achr1458813128+0.0006118210.9993882
ENST00000354386ENST00000348476KIAA0586chr1458927878+ARID4Achr1458813128+0.0004171070.99958295
ENST00000354386ENST00000395168KIAA0586chr1458927878+ARID4Achr1458813128+0.0007092860.9992907
ENST00000354386ENST00000431317KIAA0586chr1458927878+ARID4Achr1458813128+0.0003883370.9996117
ENST00000556134ENST00000355431KIAA0586chr1458927878+ARID4Achr1458813128+0.0006737780.9993262
ENST00000556134ENST00000348476KIAA0586chr1458927878+ARID4Achr1458813128+0.0004611460.9995389
ENST00000556134ENST00000395168KIAA0586chr1458927878+ARID4Achr1458813128+0.0008212380.9991787
ENST00000556134ENST00000431317KIAA0586chr1458927878+ARID4Achr1458813128+0.0004288030.99957114
ENST00000423743ENST00000355431KIAA0586chr1458927878+ARID4Achr1458813128+0.0006636750.9993363
ENST00000423743ENST00000348476KIAA0586chr1458927878+ARID4Achr1458813128+0.0004524250.99954754
ENST00000423743ENST00000395168KIAA0586chr1458927878+ARID4Achr1458813128+0.0008264580.99917346
ENST00000423743ENST00000431317KIAA0586chr1458927878+ARID4Achr1458813128+0.0004191560.9995808
ENST00000261244ENST00000355431KIAA0586chr1458927878+ARID4Achr1458813128+0.0005350250.9994649
ENST00000261244ENST00000348476KIAA0586chr1458927878+ARID4Achr1458813128+0.000369310.9996307
ENST00000261244ENST00000395168KIAA0586chr1458927878+ARID4Achr1458813128+0.0007080260.9992919
ENST00000261244ENST00000431317KIAA0586chr1458927878+ARID4Achr1458813128+0.0003385860.99966145
ENST00000354386ENST00000355431KIAA0586chr1458927878+ARID4Achr1458813129+0.0006118210.9993882
ENST00000354386ENST00000348476KIAA0586chr1458927878+ARID4Achr1458813129+0.0004171070.99958295
ENST00000354386ENST00000395168KIAA0586chr1458927878+ARID4Achr1458813129+0.0007092860.9992907
ENST00000354386ENST00000431317KIAA0586chr1458927878+ARID4Achr1458813129+0.0003883370.9996117
ENST00000556134ENST00000355431KIAA0586chr1458927878+ARID4Achr1458813129+0.0006737780.9993262
ENST00000556134ENST00000348476KIAA0586chr1458927878+ARID4Achr1458813129+0.0004611460.9995389
ENST00000556134ENST00000395168KIAA0586chr1458927878+ARID4Achr1458813129+0.0008212380.9991787
ENST00000556134ENST00000431317KIAA0586chr1458927878+ARID4Achr1458813129+0.0004288030.99957114
ENST00000423743ENST00000355431KIAA0586chr1458927878+ARID4Achr1458813129+0.0006636750.9993363
ENST00000423743ENST00000348476KIAA0586chr1458927878+ARID4Achr1458813129+0.0004524250.99954754
ENST00000423743ENST00000395168KIAA0586chr1458927878+ARID4Achr1458813129+0.0008264580.99917346
ENST00000423743ENST00000431317KIAA0586chr1458927878+ARID4Achr1458813129+0.0004191560.9995808
ENST00000261244ENST00000355431KIAA0586chr1458927878+ARID4Achr1458813129+0.0005350250.9994649
ENST00000261244ENST00000348476KIAA0586chr1458927878+ARID4Achr1458813129+0.000369310.9996307
ENST00000261244ENST00000395168KIAA0586chr1458927878+ARID4Achr1458813129+0.0007080260.9992919
ENST00000261244ENST00000431317KIAA0586chr1458927878+ARID4Achr1458813129+0.0003385860.99966145

check button Predicted full-length fusion amino acid sequences. For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among all the predicted ones.

Get the fusion protein sequences from here.

Fusion protein sequence information is available in the fasta format.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

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Fusion Protein Breakpoint Sequences for KIAA0586-ARID4A

check button +/-13 AA sequence from the breakpoints of the fusion protein sequences.
HgeneHchrHbpTgeneTchrTbpLength(fusion protein)BP in fusion proteinPeptide
KIAA0586chr1458927878ARID4Achr14588131282106609KSRPQRPKVIERVKGTPINKPPVLGY
KIAA0586chr1458927878ARID4Achr14588131282185682KSRPQRPKVIERVKGTPINKPPVLGY
KIAA0586chr1458927878ARID4Achr14588131282288705KSRPQRPKVIERVKGTPINKPPVLGY
KIAA0586chr1458927878ARID4Achr14588131282462738KSRPQRPKVIERVKGTPINKPPVLGY
KIAA0586chr1458927878ARID4Achr14588131292106609KSRPQRPKVIERVKGTPINKPPVLGY
KIAA0586chr1458927878ARID4Achr14588131292185682KSRPQRPKVIERVKGTPINKPPVLGY
KIAA0586chr1458927878ARID4Achr14588131292288705KSRPQRPKVIERVKGTPINKPPVLGY
KIAA0586chr1458927878ARID4Achr14588131292462738KSRPQRPKVIERVKGTPINKPPVLGY

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Potential FusionNeoAntigen Information of KIAA0586-ARID4A in HLA I

check button Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.
KIAA0586-ARID4A_58927878_58813128.msa

check button Potential FusionNeoAntigen Information
* We used NetMHCpan v4.1 (%rank<0.5) and deepHLApan v1.1 (immunogenic score>0.5)
Fusion geneHchrHbpTgeneTchrTbpHLA IFusionNeoAntigen peptideBinding scoreImmunogenic scoreNeoantigen start (at BP 13)Neoantigen end (at BP 13)
KIAA0586-ARID4Achr1458927878chr14588131282106HLA-A30:08RVKGTPINK0.99960.6081120
KIAA0586-ARID4Achr1458927878chr14588131282106HLA-A30:08RVKGTPINKP0.99490.60081121
KIAA0586-ARID4Achr1458927878chr14588131282106HLA-A30:01RVKGTPINK0.99970.73251120
KIAA0586-ARID4Achr1458927878chr14588131282106HLA-A30:01RVKGTPINKP0.99490.77551121
KIAA0586-ARID4Achr1458927878chr14588131282106HLA-A30:01ERVKGTPINK0.86910.66181020
KIAA0586-ARID4Achr1458927878chr14588131282106HLA-A30:01IERVKGTPINK0.98590.7378920

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Potential FusionNeoAntigen Information of KIAA0586-ARID4A in HLA II

check button Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.
KIAA0586-ARID4A_58927878_58813128.msa

check button Potential FusionNeoAntigen Information
* We used NetMHCIIpan v4.1 (%rank<0.5).
Fusion geneHchrHbpTgeneTchrTbpHLA IIFusionNeoAntigen peptideNeoantigen start (at BP 13)Neoantigen end (at BP 13)
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-0101PKVIERVKGTPINKP621
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-0102PKVIERVKGTPINKP621
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-0102RPKVIERVKGTPINK520
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-0102KVIERVKGTPINKPP722
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-0102QRPKVIERVKGTPIN419
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-0103PKVIERVKGTPINKP621
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-0103RPKVIERVKGTPINK520
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-0105PKVIERVKGTPINKP621
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-0107PKVIERVKGTPINKP621
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-0109PKVIERVKGTPINKP621
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-0109RPKVIERVKGTPINK520
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-0111PKVIERVKGTPINKP621
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-0111RPKVIERVKGTPINK520
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-0113PKVIERVKGTPINKP621
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-0113RPKVIERVKGTPINK520
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-0115PKVIERVKGTPINKP621
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-0115RPKVIERVKGTPINK520
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-0117PKVIERVKGTPINKP621
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-0119PKVIERVKGTPINKP621
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-0121PKVIERVKGTPINKP621
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-0123PKVIERVKGTPINKP621
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-0123RPKVIERVKGTPINK520
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-0123KVIERVKGTPINKPP722
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-0125PKVIERVKGTPINKP621
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-0127PKVIERVKGTPINKP621
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-0129PKVIERVKGTPINKP621
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-0131PKVIERVKGTPINKP621
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-0701PKVIERVKGTPINKP621
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-0701RPKVIERVKGTPINK520
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-0701QRPKVIERVKGTPIN419
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-0701KVIERVKGTPINKPP722
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-0703PKVIERVKGTPINKP621
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-0703RPKVIERVKGTPINK520
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-0703QRPKVIERVKGTPIN419
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-0703KVIERVKGTPINKPP722
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-0704PKVIERVKGTPINKP621
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-0704RPKVIERVKGTPINK520
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-0704QRPKVIERVKGTPIN419
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-0705PKVIERVKGTPINKP621
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-0705RPKVIERVKGTPINK520
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-0705QRPKVIERVKGTPIN419
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-0705KVIERVKGTPINKPP722
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-0706PKVIERVKGTPINKP621
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-0706RPKVIERVKGTPINK520
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-0706QRPKVIERVKGTPIN419
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-0706KVIERVKGTPINKPP722
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-0707PKVIERVKGTPINKP621
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-0707RPKVIERVKGTPINK520
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-0707QRPKVIERVKGTPIN419
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-0707KVIERVKGTPINKPP722
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-0708PKVIERVKGTPINKP621
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-0708RPKVIERVKGTPINK520
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-0708QRPKVIERVKGTPIN419
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-0708KVIERVKGTPINKPP722
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-0709PKVIERVKGTPINKP621
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-0709RPKVIERVKGTPINK520
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-0709QRPKVIERVKGTPIN419
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-0709KVIERVKGTPINKPP722
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-0711PKVIERVKGTPINKP621
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-0711RPKVIERVKGTPINK520
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-0711QRPKVIERVKGTPIN419
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-0711KVIERVKGTPINKPP722
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-0712PKVIERVKGTPINKP621
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-0712RPKVIERVKGTPINK520
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-0712QRPKVIERVKGTPIN419
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-0712KVIERVKGTPINKPP722
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-0713PKVIERVKGTPINKP621
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-0713RPKVIERVKGTPINK520
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-0713QRPKVIERVKGTPIN419
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-0713KVIERVKGTPINKPP722
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-0714PKVIERVKGTPINKP621
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-0714RPKVIERVKGTPINK520
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-0714QRPKVIERVKGTPIN419
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-0714KVIERVKGTPINKPP722
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-0715PKVIERVKGTPINKP621
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-0715RPKVIERVKGTPINK520
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-0715QRPKVIERVKGTPIN419
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-0715KVIERVKGTPINKPP722
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-0716PKVIERVKGTPINKP621
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-0716RPKVIERVKGTPINK520
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-0716QRPKVIERVKGTPIN419
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-0716KVIERVKGTPINKPP722
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-0717PKVIERVKGTPINKP621
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-0717RPKVIERVKGTPINK520
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-0717QRPKVIERVKGTPIN419
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-0717KVIERVKGTPINKPP722
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-0719PKVIERVKGTPINKP621
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-0719RPKVIERVKGTPINK520
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-0719QRPKVIERVKGTPIN419
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-0719KVIERVKGTPINKPP722
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-0807PKVIERVKGTPINKP621
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-0819PKVIERVKGTPINKP621
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-0819RPKVIERVKGTPINK520
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-0825PKVIERVKGTPINKP621
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-0825RPKVIERVKGTPINK520
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-0834PKVIERVKGTPINKP621
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-0834RPKVIERVKGTPINK520
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-0905PKVIERVKGTPINKP621
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-0905RPKVIERVKGTPINK520
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-0906PKVIERVKGTPINKP621
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-0906RPKVIERVKGTPINK520
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-1201PKVIERVKGTPINKP621
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-1203PKVIERVKGTPINKP621
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-1203RPKVIERVKGTPINK520
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-1205PKVIERVKGTPINKP621
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-1206PKVIERVKGTPINKP621
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-1207PKVIERVKGTPINKP621
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-1208PKVIERVKGTPINKP621
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-1208RPKVIERVKGTPINK520
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-1208KVIERVKGTPINKPP722
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-1210PKVIERVKGTPINKP621
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-1211PKVIERVKGTPINKP621
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-1212PKVIERVKGTPINKP621
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-1212RPKVIERVKGTPINK520
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-1213PKVIERVKGTPINKP621
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-1213RPKVIERVKGTPINK520
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-1214PKVIERVKGTPINKP621
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-1215PKVIERVKGTPINKP621
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-1215RPKVIERVKGTPINK520
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-1216PKVIERVKGTPINKP621
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-1217PKVIERVKGTPINKP621
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-1218PKVIERVKGTPINKP621
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-1218RPKVIERVKGTPINK520
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-1219PKVIERVKGTPINKP621
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-1219RPKVIERVKGTPINK520
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-1220PKVIERVKGTPINKP621
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-1220RPKVIERVKGTPINK520
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-1221PKVIERVKGTPINKP621
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-1221RPKVIERVKGTPINK520
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-1222PKVIERVKGTPINKP621
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-1222RPKVIERVKGTPINK520
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-1223PKVIERVKGTPINKP621
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-1223RPKVIERVKGTPINK520
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-1331PKVIERVKGTPINKP621
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-1354PKVIERVKGTPINKP621
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-1377PKVIERVKGTPINKP621
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-1377RPKVIERVKGTPINK520
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-1404PKVIERVKGTPINKP621
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-1428PKVIERVKGTPINKP621
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-1428RPKVIERVKGTPINK520
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-1431PKVIERVKGTPINKP621
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-1439PKVIERVKGTPINKP621
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-1439RPKVIERVKGTPINK520
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-1448PKVIERVKGTPINKP621
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-1448RPKVIERVKGTPINK520
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-1450PKVIERVKGTPINKP621
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-1455PKVIERVKGTPINKP621
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-1461PKVIERVKGTPINKP621
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-1470PKVIERVKGTPINKP621
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-1471PKVIERVKGTPINKP621
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-1501PKVIERVKGTPINKP621
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-1503PKVIERVKGTPINKP621
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-1503RPKVIERVKGTPINK520
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-1504PKVIERVKGTPINKP621
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-1504RPKVIERVKGTPINK520
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-1505PKVIERVKGTPINKP621
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-1505RPKVIERVKGTPINK520
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-1506PKVIERVKGTPINKP621
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-1507PKVIERVKGTPINKP621
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-1507RPKVIERVKGTPINK520
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-1509PKVIERVKGTPINKP621
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-1510PKVIERVKGTPINKP621
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-1510RPKVIERVKGTPINK520
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-1511PKVIERVKGTPINKP621
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-1512PKVIERVKGTPINKP621
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-1513PKVIERVKGTPINKP621
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-1515PKVIERVKGTPINKP621
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-1516PKVIERVKGTPINKP621
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-1518PKVIERVKGTPINKP621
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-1520PKVIERVKGTPINKP621
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-1521PKVIERVKGTPINKP621
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-1521RPKVIERVKGTPINK520
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-1522PKVIERVKGTPINKP621
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-1523PKVIERVKGTPINKP621
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-1523RPKVIERVKGTPINK520
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-1524PKVIERVKGTPINKP621
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-1525PKVIERVKGTPINKP621
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-1525RPKVIERVKGTPINK520
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-1527PKVIERVKGTPINKP621
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-1528PKVIERVKGTPINKP621
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-1528RPKVIERVKGTPINK520
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-1529PKVIERVKGTPINKP621
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-1529RPKVIERVKGTPINK520
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-1530PKVIERVKGTPINKP621
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-1531PKVIERVKGTPINKP621
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-1532PKVIERVKGTPINKP621
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-1533PKVIERVKGTPINKP621
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-1534PKVIERVKGTPINKP621
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-1534RPKVIERVKGTPINK520
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-1535PKVIERVKGTPINKP621
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-1535RPKVIERVKGTPINK520
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-1536PKVIERVKGTPINKP621
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-1537PKVIERVKGTPINKP621
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-1537RPKVIERVKGTPINK520
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-1540PKVIERVKGTPINKP621
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-1541PKVIERVKGTPINKP621
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-1542PKVIERVKGTPINKP621
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-1543PKVIERVKGTPINKP621
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-1545PKVIERVKGTPINKP621
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-1546PKVIERVKGTPINKP621
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-1548PKVIERVKGTPINKP621
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-1548RPKVIERVKGTPINK520
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-1549PKVIERVKGTPINKP621
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-1549RPKVIERVKGTPINK520
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-1601PKVIERVKGTPINKP621
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-1602PKVIERVKGTPINKP621
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-1602RPKVIERVKGTPINK520
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-1603PKVIERVKGTPINKP621
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-1604PKVIERVKGTPINKP621
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-1604RPKVIERVKGTPINK520
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-1605PKVIERVKGTPINKP621
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-1607PKVIERVKGTPINKP621
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-1608PKVIERVKGTPINKP621
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-1609PKVIERVKGTPINKP621
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-1610PKVIERVKGTPINKP621
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-1611PKVIERVKGTPINKP621
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-1611RPKVIERVKGTPINK520
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-1612PKVIERVKGTPINKP621
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-1612RPKVIERVKGTPINK520
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-1614PKVIERVKGTPINKP621
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-1614RPKVIERVKGTPINK520
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-1615PKVIERVKGTPINKP621
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-1615RPKVIERVKGTPINK520
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-1615KVIERVKGTPINKPP722
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-1615QRPKVIERVKGTPIN419
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-1616PKVIERVKGTPINKP621
KIAA0586-ARID4Achr1458927878chr14588131282106DRB1-1616RPKVIERVKGTPINK520
KIAA0586-ARID4Achr1458927878chr14588131282106DRB5-0204PKVIERVKGTPINKP621
KIAA0586-ARID4Achr1458927878chr14588131282106DRB5-0205PKVIERVKGTPINKP621

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Fusion breakpoint peptide structures of KIAA0586-ARID4A

check button3D structures of the fusion breakpoint peptide of 14AA sequence that have potential fusion neoantigens
* The minimum length of the amino acid sequence in RoseTTAFold is 14AA. Here, we predicted the 14AA fusion protein breakpoint sequence not the fusion neoantigen peptide, which is shorter than 14 AA.
File nameBPseqHgeneTgeneHchrHbpTchrTbpAAlen
6751PKVIERVKGTPINKKIAA0586ARID4Achr1458927878chr14588131282106

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Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D of KIAA0586-ARID4A

check buttonVirtual screening between 25 HLAs (from PDB) and FusionNeoAntigens
* We used Glide to predict the interaction between HLAs and neoantigens.
HLA allelePDB IDFile nameBPseqDocking scoreGlide score
HLA-B14:023BVN6751PKVIERVKGTPINK-7.9962-8.1096
HLA-B14:023BVN6751PKVIERVKGTPINK-5.70842-6.74372
HLA-B52:013W396751PKVIERVKGTPINK-6.83737-6.95077
HLA-B52:013W396751PKVIERVKGTPINK-4.4836-5.5189
HLA-A11:014UQ26751PKVIERVKGTPINK-10.0067-10.1201
HLA-A11:014UQ26751PKVIERVKGTPINK-9.03915-10.0745
HLA-A24:025HGA6751PKVIERVKGTPINK-6.56204-6.67544
HLA-A24:025HGA6751PKVIERVKGTPINK-5.42271-6.45801
HLA-B44:053DX86751PKVIERVKGTPINK-7.85648-8.89178
HLA-B44:053DX86751PKVIERVKGTPINK-5.3978-5.5112
HLA-A02:016TDR6751PKVIERVKGTPINK-3.37154-4.40684

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Vaccine Design for the FusionNeoAntigens of KIAA0586-ARID4A

check button mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-Is.
Fusion geneHchrHbpTchrTbpStart in +/-13AAEnd in +/-13AAFusionNeoAntigen peptide sequenceFusionNeoAntigen RNA sequence
KIAA0586-ARID4Achr1458927878chr14588131281020ERVKGTPINKGAGTTAAAGGTACTCCAATCAACAAACCAC
KIAA0586-ARID4Achr1458927878chr14588131281120RVKGTPINKTTAAAGGTACTCCAATCAACAAACCAC
KIAA0586-ARID4Achr1458927878chr14588131281121RVKGTPINKPTTAAAGGTACTCCAATCAACAAACCACCTG
KIAA0586-ARID4Achr1458927878chr1458813128920IERVKGTPINKAACGAGTTAAAGGTACTCCAATCAACAAACCAC

check button mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-IIs.
Fusion geneHchrHbpTchrTbpStart in +/-13AAEnd in +/-13AAFusionNeoAntigen peptideFusionNEoAntigen RNA sequence
KIAA0586-ARID4Achr1458927878chr1458813128419QRPKVIERVKGTPINGACCAAAAGTAATAGAACGAGTTAAAGGTACTCCAATCAACAAAC
KIAA0586-ARID4Achr1458927878chr1458813128520RPKVIERVKGTPINKCAAAAGTAATAGAACGAGTTAAAGGTACTCCAATCAACAAACCAC
KIAA0586-ARID4Achr1458927878chr1458813128621PKVIERVKGTPINKPAAGTAATAGAACGAGTTAAAGGTACTCCAATCAACAAACCACCTG
KIAA0586-ARID4Achr1458927878chr1458813128722KVIERVKGTPINKPPTAATAGAACGAGTTAAAGGTACTCCAATCAACAAACCACCTGTTT

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Information of the samples that have these potential fusion neoantigens of KIAA0586-ARID4A

check button These samples were reported as having these fusion breakpoints. For individual breakpoints, we checked the open reading frames considering multiple gene isoforms and chose the in-frame fusion genes only. Then, we made fusion protein sequences and predicted the fusion neoantigens. These fusion-positive samples may have these potential fusion neoantigens.
Cancer typeFusion geneHchrHbpHenstTchrTbpTenstSample
STADKIAA0586-ARID4Achr1458927878ENST00000261244chr1458813128ENST00000348476TCGA-BR-A4QI

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Potential target of CAR-T therapy development for KIAA0586-ARID4A

check button Predicted 3D structure. We used RoseTTAFold.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, to provide the retention of the transmembrane domain, we only show the protein feature retention information of those transmembrane features


* Minus value of BPloci means that the break point is located before the CDS.
- In-frame and retained 'Transmembrane'.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

check button Subcellular localization prediction of the transmembrane domain retained fusion proteins
* We used DeepLoc 1.0. The order of the X-axis of the barplot is as follows: Entry_ID, Localization, Type, Nucleus, Cytoplasm, Extracellular, Mitochondrion, Cell_membrane, Endoplasmic_reticulum, Plastid, Golgi.apparatus, Lysosome.Vacuole, Peroxisome. Y-axis is the output score of DeepLoc. Clicking the image will open a new tab with a large image.
HgeneHchrHbpHenstTgeneTchrTbpTenstDeepLoc result

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Related Drugs to KIAA0586-ARID4A

check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to KIAA0586-ARID4A

check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource