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Fusion Protein:KLF7-PARD3B

Fusion Gene and Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: KLF7-PARD3B
	FusionPDB ID: 42888
	FusionGDB2.0 ID: 42888
		Hgene	Tgene
	Gene symbol	KLF7	PARD3B
	Gene ID	8609	117583
	Gene name	Kruppel like factor 7	par-3 family cell polarity regulator beta
	Synonyms	UKLF	ALS2CR19\|PAR3B\|PAR3L\|PAR3beta
	Cytomap	2q33.3	2q33.3
	Type of gene	protein-coding	protein-coding
	Description	Krueppel-like factor 7Kruppel-like factor 7 (ubiquitous)ubiquitous Kruppel-like factorubiquitous Kruppel-like transcription factor	partitioning defective 3 homolog BPAR3-L proteinamyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 19amyotrophic lateral sclerosis 2 chromosomal region candidate gene 19 proteinpar-3 partitioning defective 3 homolog Bpartitioning
	Modification date	20200322	20200313
	UniProtAcc	O75840 Main function of 5'-partner protein: FUNCTION: Transcriptional factor (PubMed:9774444, PubMed:16339272). Plays a critical role in neuronal morphogenesis and survival of sensory neurons (By similarity). Represses the corneal epithelium differentiation (PubMed:28916725). Acts also as a metabolic regulator, by modulating insulin sensitivity in pancreatic beta cells and skeletal muscle cells (PubMed:16339272). Inhibits transcriptional inducers of adipogenesis and has a repressive role in the expression of several adipokines, including leptin (PubMed:16339272). {ECO:0000250\|UniProtKB:Q99JB0, ECO:0000269\|PubMed:16339272, ECO:0000269\|PubMed:28916725, ECO:0000269\|PubMed:9774444}.	.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000309446, ENST00000412414, ENST00000421199, ENST00000423015, ENST00000458272, ENST00000467833,	ENST00000488622, ENST00000349953, ENST00000351153, ENST00000358768, ENST00000406610, ENST00000462231,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	7 X 4 X 7=196	17 X 20 X 10=3400
	# samples	8	23
	** MAII score	log2(8/196*10)=-1.29278174922785 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(23/3400*10)=-3.88582898008069 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Fusion gene context	PubMed: KLF7 [Title/Abstract] AND PARD3B [Title/Abstract] AND fusion [Title/Abstract]
Fusion neoantigen context	PubMed: KLF7 [Title/Abstract] AND PARD3B [Title/Abstract] AND neoantigen [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	KLF7(207988498)-PARD3B(205912304), # samples:3
Anticipated loss of major functional domain due to fusion event.	KLF7-PARD3B seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. KLF7-PARD3B seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. KLF7-PARD3B seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. KLF7-PARD3B seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	KLF7	GO:0045944	positive regulation of transcription by RNA polymerase II	9774444

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:207988498/chr2:205912304)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Retention analysis results of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features, are available here.

Fusion gene breakpoints across KLF7 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across PARD3B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Amino Acid Sequences

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000309446	KLF7	chr2	207988498	-	ENST00000406610	PARD3B	chr2	205912304	+	8683	1110	359	4333	1324
ENST00000309446	KLF7	chr2	207988498	-	ENST00000462231	PARD3B	chr2	205912304	+	3524	1110	359	3523	1055
ENST00000309446	KLF7	chr2	207988498	-	ENST00000349953	PARD3B	chr2	205912304	+	4031	1110	359	4030	1224
ENST00000309446	KLF7	chr2	207988498	-	ENST00000358768	PARD3B	chr2	205912304	+	4148	1110	359	4147	1263
ENST00000309446	KLF7	chr2	207988498	-	ENST00000351153	PARD3B	chr2	205912304	+	4127	1110	359	4126	1256
ENST00000421199	KLF7	chr2	207988498	-	ENST00000406610	PARD3B	chr2	205912304	+	8311	738	104	3961	1285
ENST00000421199	KLF7	chr2	207988498	-	ENST00000462231	PARD3B	chr2	205912304	+	3152	738	104	3151	1016
ENST00000421199	KLF7	chr2	207988498	-	ENST00000349953	PARD3B	chr2	205912304	+	3659	738	104	3658	1185
ENST00000421199	KLF7	chr2	207988498	-	ENST00000358768	PARD3B	chr2	205912304	+	3776	738	104	3775	1224
ENST00000421199	KLF7	chr2	207988498	-	ENST00000351153	PARD3B	chr2	205912304	+	3755	738	104	3754	1217
ENST00000412414	KLF7	chr2	207988498	-	ENST00000406610	PARD3B	chr2	205912304	+	8262	689	40	3912	1290
ENST00000412414	KLF7	chr2	207988498	-	ENST00000462231	PARD3B	chr2	205912304	+	3103	689	40	3102	1021
ENST00000412414	KLF7	chr2	207988498	-	ENST00000349953	PARD3B	chr2	205912304	+	3610	689	40	3609	1190
ENST00000412414	KLF7	chr2	207988498	-	ENST00000358768	PARD3B	chr2	205912304	+	3727	689	40	3726	1229
ENST00000412414	KLF7	chr2	207988498	-	ENST00000351153	PARD3B	chr2	205912304	+	3706	689	40	3705	1222
ENST00000309446	KLF7	chr2	208030191	-	ENST00000406610	PARD3B	chr2	205829875	+	8224	479	359	3874	1171
ENST00000309446	KLF7	chr2	208030191	-	ENST00000462231	PARD3B	chr2	205829875	+	3065	479	359	3064	902
ENST00000309446	KLF7	chr2	208030191	-	ENST00000349953	PARD3B	chr2	205829875	+	3572	479	359	3571	1071
ENST00000309446	KLF7	chr2	208030191	-	ENST00000358768	PARD3B	chr2	205829875	+	3689	479	359	3688	1110
ENST00000309446	KLF7	chr2	208030191	-	ENST00000351153	PARD3B	chr2	205829875	+	3668	479	359	3667	1103
ENST00000423015	KLF7	chr2	208030191	-	ENST00000406610	PARD3B	chr2	205829875	+	8076	331	211	3726	1171
ENST00000423015	KLF7	chr2	208030191	-	ENST00000462231	PARD3B	chr2	205829875	+	2917	331	211	2916	902
ENST00000423015	KLF7	chr2	208030191	-	ENST00000349953	PARD3B	chr2	205829875	+	3424	331	211	3423	1071
ENST00000423015	KLF7	chr2	208030191	-	ENST00000358768	PARD3B	chr2	205829875	+	3541	331	211	3540	1110
ENST00000423015	KLF7	chr2	208030191	-	ENST00000351153	PARD3B	chr2	205829875	+	3520	331	211	3519	1103
ENST00000458272	KLF7	chr2	208030191	-	ENST00000406610	PARD3B	chr2	205829875	+	7850	105	3	3500	1165
ENST00000458272	KLF7	chr2	208030191	-	ENST00000462231	PARD3B	chr2	205829875	+	2691	105	3	2690	895
ENST00000458272	KLF7	chr2	208030191	-	ENST00000349953	PARD3B	chr2	205829875	+	3198	105	3	3197	1064
ENST00000458272	KLF7	chr2	208030191	-	ENST00000358768	PARD3B	chr2	205829875	+	3315	105	3	3314	1103
ENST00000458272	KLF7	chr2	208030191	-	ENST00000351153	PARD3B	chr2	205829875	+	3294	105	3	3293	1096

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000309446	ENST00000406610	KLF7	chr2	207988498	-	PARD3B	chr2	205912304	+	0.000525674	0.99947435
ENST00000309446	ENST00000462231	KLF7	chr2	207988498	-	PARD3B	chr2	205912304	+	0.001545617	0.99845433
ENST00000309446	ENST00000349953	KLF7	chr2	207988498	-	PARD3B	chr2	205912304	+	0.003122394	0.99687755
ENST00000309446	ENST00000358768	KLF7	chr2	207988498	-	PARD3B	chr2	205912304	+	0.003263619	0.99673635
ENST00000309446	ENST00000351153	KLF7	chr2	207988498	-	PARD3B	chr2	205912304	+	0.003791994	0.99620795
ENST00000421199	ENST00000406610	KLF7	chr2	207988498	-	PARD3B	chr2	205912304	+	0.000374156	0.9996258
ENST00000421199	ENST00000462231	KLF7	chr2	207988498	-	PARD3B	chr2	205912304	+	0.001079517	0.99892056
ENST00000421199	ENST00000349953	KLF7	chr2	207988498	-	PARD3B	chr2	205912304	+	0.002383005	0.997617
ENST00000421199	ENST00000358768	KLF7	chr2	207988498	-	PARD3B	chr2	205912304	+	0.002452489	0.99754745
ENST00000421199	ENST00000351153	KLF7	chr2	207988498	-	PARD3B	chr2	205912304	+	0.002875527	0.9971245
ENST00000412414	ENST00000406610	KLF7	chr2	207988498	-	PARD3B	chr2	205912304	+	0.000340813	0.9996592
ENST00000412414	ENST00000462231	KLF7	chr2	207988498	-	PARD3B	chr2	205912304	+	0.000970893	0.99902916
ENST00000412414	ENST00000349953	KLF7	chr2	207988498	-	PARD3B	chr2	205912304	+	0.002142028	0.997858
ENST00000412414	ENST00000358768	KLF7	chr2	207988498	-	PARD3B	chr2	205912304	+	0.002208751	0.9977913
ENST00000412414	ENST00000351153	KLF7	chr2	207988498	-	PARD3B	chr2	205912304	+	0.002580528	0.9974195
ENST00000309446	ENST00000406610	KLF7	chr2	208030191	-	PARD3B	chr2	205829875	+	0.000491914	0.999508
ENST00000309446	ENST00000462231	KLF7	chr2	208030191	-	PARD3B	chr2	205829875	+	0.002110317	0.9978897
ENST00000309446	ENST00000349953	KLF7	chr2	208030191	-	PARD3B	chr2	205829875	+	0.003186252	0.9968137
ENST00000309446	ENST00000358768	KLF7	chr2	208030191	-	PARD3B	chr2	205829875	+	0.003831673	0.9961683
ENST00000309446	ENST00000351153	KLF7	chr2	208030191	-	PARD3B	chr2	205829875	+	0.004331827	0.9956682
ENST00000423015	ENST00000406610	KLF7	chr2	208030191	-	PARD3B	chr2	205829875	+	0.000422645	0.99957734
ENST00000423015	ENST00000462231	KLF7	chr2	208030191	-	PARD3B	chr2	205829875	+	0.002127517	0.9978725
ENST00000423015	ENST00000349953	KLF7	chr2	208030191	-	PARD3B	chr2	205829875	+	0.002940516	0.9970594
ENST00000423015	ENST00000358768	KLF7	chr2	208030191	-	PARD3B	chr2	205829875	+	0.003463374	0.9965366
ENST00000423015	ENST00000351153	KLF7	chr2	208030191	-	PARD3B	chr2	205829875	+	0.003946203	0.9960538
ENST00000458272	ENST00000406610	KLF7	chr2	208030191	-	PARD3B	chr2	205829875	+	0.000324217	0.99967575
ENST00000458272	ENST00000462231	KLF7	chr2	208030191	-	PARD3B	chr2	205829875	+	0.002198723	0.99780124
ENST00000458272	ENST00000349953	KLF7	chr2	208030191	-	PARD3B	chr2	205829875	+	0.002471563	0.9975285
ENST00000458272	ENST00000358768	KLF7	chr2	208030191	-	PARD3B	chr2	205829875	+	0.002929854	0.9970701
ENST00000458272	ENST00000351153	KLF7	chr2	208030191	-	PARD3B	chr2	205829875	+	0.003345	0.996655

Predicted full-length fusion amino acid sequences. For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among all the predicted ones.

Get the fusion protein sequences from here.

Fusion protein sequence information is available in the fasta format.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

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Fusion Protein Breakpoint Sequences for KLF7-PARD3B

+/-13 AA sequence from the breakpoints of the fusion protein sequences.

Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	Length(fusion protein)	BP in fusion protein	Peptide
KLF7	chr2	207988498	PARD3B	chr2	205912304	1110	250	KSSHLKAHQRTHTGTPLLVRRSSDPV
KLF7	chr2	207988498	PARD3B	chr2	205912304	689	216	KSSHLKAHQRTHTGTPLLVRRSSDPV
KLF7	chr2	207988498	PARD3B	chr2	205912304	738	211	KSSHLKAHQRTHTGTPLLVRRSSDPV
KLF7	chr2	208030191	PARD3B	chr2	205829875	105	34	FSALPSLEETWQQLIAVFEEQEPLHK
KLF7	chr2	208030191	PARD3B	chr2	205829875	331	40	FSALPSLEETWQQLIAVFEEQEPLHK
KLF7	chr2	208030191	PARD3B	chr2	205829875	479	40	FSALPSLEETWQQLIAVFEEQEPLHK

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Potential FusionNeoAntigen Information of KLF7-PARD3B in HLA I

Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.

KLF7-PARD3B_207988498_205912304.msa
KLF7-PARD3B_208030191_205829875.msa

Potential FusionNeoAntigen Information
* We used NetMHCpan v4.1 (%rank<0.5) and deepHLApan v1.1 (immunogenic score>0.5)

Fusion gene	Hchr	Hbp	Tgene	Tchr	Tbp	HLA I	FusionNeoAntigen peptide	Binding score	Immunogenic score	Neoantigen start (at BP 13)	Neoantigen end (at BP 13)
KLF7-PARD3B	chr2	207988498	chr2	205912304	1110	HLA-B39:01	THTGTPLL	0.9998	0.9487	10	18
KLF7-PARD3B	chr2	207988498	chr2	205912304	1110	HLA-B39:24	THTGTPLL	0.9998	0.8006	10	18
KLF7-PARD3B	chr2	207988498	chr2	205912304	1110	HLA-B38:01	THTGTPLL	0.9995	0.9843	10	18
KLF7-PARD3B	chr2	207988498	chr2	205912304	1110	HLA-B38:02	THTGTPLL	0.9995	0.9827	10	18
KLF7-PARD3B	chr2	207988498	chr2	205912304	1110	HLA-B15:10	THTGTPLL	0.9987	0.7337	10	18
KLF7-PARD3B	chr2	207988498	chr2	205912304	1110	HLA-B15:37	THTGTPLL	0.9925	0.7283	10	18
KLF7-PARD3B	chr2	207988498	chr2	205912304	1110	HLA-B27:07	QRTHTGTPL	0.9984	0.5008	8	17
KLF7-PARD3B	chr2	207988498	chr2	205912304	1110	HLA-B39:06	THTGTPLLV	0.9979	0.8683	10	19
KLF7-PARD3B	chr2	207988498	chr2	205912304	1110	HLA-B39:01	THTGTPLLV	0.9979	0.8899	10	19
KLF7-PARD3B	chr2	207988498	chr2	205912304	1110	HLA-B39:24	THTGTPLLV	0.9975	0.7879	10	19
KLF7-PARD3B	chr2	207988498	chr2	205912304	1110	HLA-B38:01	THTGTPLLV	0.9971	0.956	10	19
KLF7-PARD3B	chr2	207988498	chr2	205912304	1110	HLA-B38:02	THTGTPLLV	0.9958	0.958	10	19
KLF7-PARD3B	chr2	207988498	chr2	205912304	1110	HLA-B15:17	RTHTGTPLL	0.9945	0.8695	9	18
KLF7-PARD3B	chr2	207988498	chr2	205912304	1110	HLA-B39:01	QRTHTGTPL	0.9923	0.767	8	17
KLF7-PARD3B	chr2	207988498	chr2	205912304	1110	HLA-B15:16	RTHTGTPLL	0.9922	0.8529	9	18
KLF7-PARD3B	chr2	207988498	chr2	205912304	1110	HLA-A30:08	RTHTGTPLL	0.9915	0.8087	9	18
KLF7-PARD3B	chr2	207988498	chr2	205912304	1110	HLA-B14:02	QRTHTGTPL	0.9869	0.7694	8	17
KLF7-PARD3B	chr2	207988498	chr2	205912304	1110	HLA-B14:01	QRTHTGTPL	0.9869	0.7694	8	17
KLF7-PARD3B	chr2	207988498	chr2	205912304	1110	HLA-B57:03	RTHTGTPLL	0.9867	0.9785	9	18
KLF7-PARD3B	chr2	207988498	chr2	205912304	1110	HLA-A68:24	HTGTPLLVR	0.9856	0.8128	11	20
KLF7-PARD3B	chr2	207988498	chr2	205912304	1110	HLA-A11:10	HTGTPLLVR	0.9846	0.5665	11	20
KLF7-PARD3B	chr2	207988498	chr2	205912304	1110	HLA-A68:03	HTGTPLLVR	0.9788	0.8015	11	20
KLF7-PARD3B	chr2	207988498	chr2	205912304	1110	HLA-A68:08	HTGTPLLVR	0.9574	0.8069	11	20
KLF7-PARD3B	chr2	207988498	chr2	205912304	1110	HLA-A31:06	HTGTPLLVR	0.9527	0.8668	11	20
KLF7-PARD3B	chr2	207988498	chr2	205912304	1110	HLA-B15:10	THTGTPLLV	0.9519	0.6626	10	19
KLF7-PARD3B	chr2	207988498	chr2	205912304	1110	HLA-B14:02	THTGTPLLV	0.9518	0.908	10	19
KLF7-PARD3B	chr2	207988498	chr2	205912304	1110	HLA-B14:01	THTGTPLLV	0.9518	0.908	10	19
KLF7-PARD3B	chr2	207988498	chr2	205912304	1110	HLA-A32:13	RTHTGTPLL	0.9517	0.9513	9	18
KLF7-PARD3B	chr2	207988498	chr2	205912304	1110	HLA-A68:05	HTGTPLLVR	0.9483	0.8048	11	20
KLF7-PARD3B	chr2	207988498	chr2	205912304	1110	HLA-A74:03	HTGTPLLVR	0.9367	0.884	11	20
KLF7-PARD3B	chr2	207988498	chr2	205912304	1110	HLA-A74:11	HTGTPLLVR	0.9367	0.884	11	20
KLF7-PARD3B	chr2	207988498	chr2	205912304	1110	HLA-A74:09	HTGTPLLVR	0.9367	0.884	11	20
KLF7-PARD3B	chr2	207988498	chr2	205912304	1110	HLA-A66:01	HTGTPLLVR	0.9279	0.7974	11	20
KLF7-PARD3B	chr2	207988498	chr2	205912304	1110	HLA-A68:06	HTGTPLLVR	0.9265	0.8126	11	20
KLF7-PARD3B	chr2	207988498	chr2	205912304	1110	HLA-A34:02	HTGTPLLVR	0.9222	0.7304	11	20
KLF7-PARD3B	chr2	207988498	chr2	205912304	1110	HLA-A31:02	HTGTPLLVR	0.8723	0.9028	11	20
KLF7-PARD3B	chr2	207988498	chr2	205912304	1110	HLA-A34:01	HTGTPLLVR	0.8532	0.7826	11	20
KLF7-PARD3B	chr2	207988498	chr2	205912304	1110	HLA-A34:05	HTGTPLLVR	0.8532	0.7826	11	20
KLF7-PARD3B	chr2	207988498	chr2	205912304	1110	HLA-B15:37	THTGTPLLV	0.8153	0.6753	10	19
KLF7-PARD3B	chr2	207988498	chr2	205912304	1110	HLA-A66:03	HTGTPLLVR	0.7351	0.8443	11	20
KLF7-PARD3B	chr2	207988498	chr2	205912304	1110	HLA-A33:05	HTGTPLLVR	0.7194	0.6577	11	20
KLF7-PARD3B	chr2	207988498	chr2	205912304	1110	HLA-A33:01	HTGTPLLVR	0.7194	0.6577	11	20
KLF7-PARD3B	chr2	207988498	chr2	205912304	1110	HLA-B15:18	THTGTPLLV	0.6013	0.8009	10	19
KLF7-PARD3B	chr2	207988498	chr2	205912304	1110	HLA-B13:01	RTHTGTPLL	0.1844	0.9722	9	18
KLF7-PARD3B	chr2	207988498	chr2	205912304	1110	HLA-B27:07	QRTHTGTPLL	0.9995	0.6372	8	18
KLF7-PARD3B	chr2	207988498	chr2	205912304	1110	HLA-A30:08	RTHTGTPLLV	0.9976	0.7311	9	19
KLF7-PARD3B	chr2	207988498	chr2	205912304	1110	HLA-A68:24	HTGTPLLVRR	0.9818	0.8458	11	21
KLF7-PARD3B	chr2	207988498	chr2	205912304	1110	HLA-A68:03	HTGTPLLVRR	0.9758	0.8302	11	21
KLF7-PARD3B	chr2	207988498	chr2	205912304	1110	HLA-A68:08	HTGTPLLVRR	0.9585	0.8521	11	21
KLF7-PARD3B	chr2	207988498	chr2	205912304	1110	HLA-A74:11	HTGTPLLVRR	0.9536	0.9086	11	21
KLF7-PARD3B	chr2	207988498	chr2	205912304	1110	HLA-A74:03	HTGTPLLVRR	0.9536	0.9086	11	21
KLF7-PARD3B	chr2	207988498	chr2	205912304	1110	HLA-A74:09	HTGTPLLVRR	0.9536	0.9086	11	21
KLF7-PARD3B	chr2	207988498	chr2	205912304	1110	HLA-A68:06	HTGTPLLVRR	0.9472	0.8319	11	21
KLF7-PARD3B	chr2	207988498	chr2	205912304	1110	HLA-A31:06	HTGTPLLVRR	0.9399	0.8457	11	21
KLF7-PARD3B	chr2	207988498	chr2	205912304	1110	HLA-A68:05	HTGTPLLVRR	0.9364	0.838	11	21
KLF7-PARD3B	chr2	207988498	chr2	205912304	1110	HLA-A34:02	HTGTPLLVRR	0.9316	0.577	11	21
KLF7-PARD3B	chr2	207988498	chr2	205912304	1110	HLA-B07:10	HQRTHTGTPL	0.8834	0.5286	7	17
KLF7-PARD3B	chr2	207988498	chr2	205912304	1110	HLA-A66:03	HTGTPLLVRR	0.7974	0.8273	11	21
KLF7-PARD3B	chr2	207988498	chr2	205912304	1110	HLA-A33:05	HTGTPLLVRR	0.7165	0.7148	11	21
KLF7-PARD3B	chr2	207988498	chr2	205912304	1110	HLA-A33:01	HTGTPLLVRR	0.7165	0.7148	11	21
KLF7-PARD3B	chr2	207988498	chr2	205912304	1110	HLA-B07:10	QRTHTGTPLL	0.6931	0.6114	8	18
KLF7-PARD3B	chr2	207988498	chr2	205912304	1110	HLA-A74:11	RTHTGTPLLVR	0.9984	0.7548	9	20
KLF7-PARD3B	chr2	207988498	chr2	205912304	1110	HLA-A74:09	RTHTGTPLLVR	0.9984	0.7548	9	20
KLF7-PARD3B	chr2	207988498	chr2	205912304	1110	HLA-A74:03	RTHTGTPLLVR	0.9984	0.7548	9	20
KLF7-PARD3B	chr2	207988498	chr2	205912304	1110	HLA-A31:06	RTHTGTPLLVR	0.9956	0.5486	9	20
KLF7-PARD3B	chr2	207988498	chr2	205912304	1110	HLA-A31:02	RTHTGTPLLVR	0.9941	0.7382	9	20
KLF7-PARD3B	chr2	207988498	chr2	205912304	1110	HLA-B48:01	HQRTHTGTPLL	0.9935	0.5587	7	18
KLF7-PARD3B	chr2	207988498	chr2	205912304	1110	HLA-B07:10	AHQRTHTGTPL	0.8273	0.6301	6	17
KLF7-PARD3B	chr2	207988498	chr2	205912304	1110	HLA-B39:09	THTGTPLL	0.9998	0.8709	10	18
KLF7-PARD3B	chr2	207988498	chr2	205912304	1110	HLA-B39:12	THTGTPLL	0.9997	0.9498	10	18
KLF7-PARD3B	chr2	207988498	chr2	205912304	1110	HLA-B39:05	THTGTPLL	0.9993	0.9449	10	18
KLF7-PARD3B	chr2	207988498	chr2	205912304	1110	HLA-B14:03	THTGTPLL	0.8431	0.9352	10	18
KLF7-PARD3B	chr2	207988498	chr2	205912304	1110	HLA-C15:04	RTHTGTPLL	0.9995	0.9383	9	18
KLF7-PARD3B	chr2	207988498	chr2	205912304	1110	HLA-C15:06	RTHTGTPLL	0.9989	0.9239	9	18
KLF7-PARD3B	chr2	207988498	chr2	205912304	1110	HLA-C03:07	RTHTGTPLL	0.9978	0.9684	9	18
KLF7-PARD3B	chr2	207988498	chr2	205912304	1110	HLA-B39:12	THTGTPLLV	0.9977	0.8858	10	19
KLF7-PARD3B	chr2	207988498	chr2	205912304	1110	HLA-B39:09	THTGTPLLV	0.9976	0.8095	10	19
KLF7-PARD3B	chr2	207988498	chr2	205912304	1110	HLA-C03:08	RTHTGTPLL	0.9965	0.8706	9	18
KLF7-PARD3B	chr2	207988498	chr2	205912304	1110	HLA-B39:05	THTGTPLLV	0.9964	0.8719	10	19
KLF7-PARD3B	chr2	207988498	chr2	205912304	1110	HLA-B39:09	QRTHTGTPL	0.9938	0.6033	8	17
KLF7-PARD3B	chr2	207988498	chr2	205912304	1110	HLA-B39:12	QRTHTGTPL	0.992	0.7696	8	17
KLF7-PARD3B	chr2	207988498	chr2	205912304	1110	HLA-A68:01	HTGTPLLVR	0.9856	0.8128	11	20
KLF7-PARD3B	chr2	207988498	chr2	205912304	1110	HLA-B39:05	QRTHTGTPL	0.9794	0.7484	8	17
KLF7-PARD3B	chr2	207988498	chr2	205912304	1110	HLA-C06:03	RTHTGTPLL	0.9496	0.9882	9	18
KLF7-PARD3B	chr2	207988498	chr2	205912304	1110	HLA-C12:12	RTHTGTPLL	0.9483	0.9613	9	18
KLF7-PARD3B	chr2	207988498	chr2	205912304	1110	HLA-A31:01	HTGTPLLVR	0.944	0.8952	11	20
KLF7-PARD3B	chr2	207988498	chr2	205912304	1110	HLA-A33:03	HTGTPLLVR	0.9409	0.7194	11	20
KLF7-PARD3B	chr2	207988498	chr2	205912304	1110	HLA-C02:06	RTHTGTPLL	0.8907	0.9649	9	18
KLF7-PARD3B	chr2	207988498	chr2	205912304	1110	HLA-B14:03	QRTHTGTPL	0.7214	0.7426	8	17
KLF7-PARD3B	chr2	207988498	chr2	205912304	1110	HLA-B14:03	THTGTPLLV	0.3954	0.8862	10	19
KLF7-PARD3B	chr2	207988498	chr2	205912304	1110	HLA-A68:01	HTGTPLLVRR	0.9818	0.8458	11	21
KLF7-PARD3B	chr2	207988498	chr2	205912304	1110	HLA-A31:01	HTGTPLLVRR	0.9618	0.9009	11	21
KLF7-PARD3B	chr2	207988498	chr2	205912304	1110	HLA-A33:03	HTGTPLLVRR	0.9584	0.7423	11	21
KLF7-PARD3B	chr2	207988498	chr2	205912304	1110	HLA-B15:04	HQRTHTGTPL	0.9084	0.7319	7	17
KLF7-PARD3B	chr2	207988498	chr2	205912304	1110	HLA-A31:01	RTHTGTPLLVR	0.9984	0.7122	9	20
KLF7-PARD3B	chr2	207988498	chr2	205912304	1110	HLA-B39:31	THTGTPLL	0.9998	0.9482	10	18
KLF7-PARD3B	chr2	207988498	chr2	205912304	1110	HLA-B38:05	THTGTPLL	0.9995	0.9843	10	18
KLF7-PARD3B	chr2	207988498	chr2	205912304	1110	HLA-B15:09	THTGTPLL	0.9982	0.9206	10	18
KLF7-PARD3B	chr2	207988498	chr2	205912304	1110	HLA-B39:11	THTGTPLL	0.9711	0.9319	10	18
KLF7-PARD3B	chr2	207988498	chr2	205912304	1110	HLA-C15:09	RTHTGTPLL	0.9995	0.9383	9	18
KLF7-PARD3B	chr2	207988498	chr2	205912304	1110	HLA-C15:02	RTHTGTPLL	0.9991	0.938	9	18
KLF7-PARD3B	chr2	207988498	chr2	205912304	1110	HLA-B27:06	QRTHTGTPL	0.999	0.59	8	17
KLF7-PARD3B	chr2	207988498	chr2	205912304	1110	HLA-C15:05	RTHTGTPLL	0.9989	0.9423	9	18
KLF7-PARD3B	chr2	207988498	chr2	205912304	1110	HLA-B39:31	THTGTPLLV	0.998	0.8885	10	19
KLF7-PARD3B	chr2	207988498	chr2	205912304	1110	HLA-B38:05	THTGTPLLV	0.9971	0.956	10	19
KLF7-PARD3B	chr2	207988498	chr2	205912304	1110	HLA-C03:17	RTHTGTPLL	0.9953	0.9785	9	18
KLF7-PARD3B	chr2	207988498	chr2	205912304	1110	HLA-C03:05	RTHTGTPLL	0.9948	0.9423	9	18
KLF7-PARD3B	chr2	207988498	chr2	205912304	1110	HLA-B58:06	RTHTGTPLL	0.9935	0.9053	9	18
KLF7-PARD3B	chr2	207988498	chr2	205912304	1110	HLA-B39:31	QRTHTGTPL	0.9929	0.7673	8	17
KLF7-PARD3B	chr2	207988498	chr2	205912304	1110	HLA-A30:01	RTHTGTPLL	0.9919	0.9216	9	18
KLF7-PARD3B	chr2	207988498	chr2	205912304	1110	HLA-A32:01	RTHTGTPLL	0.9914	0.9625	9	18
KLF7-PARD3B	chr2	207988498	chr2	205912304	1110	HLA-C16:01	RTHTGTPLL	0.9892	0.9871	9	18
KLF7-PARD3B	chr2	207988498	chr2	205912304	1110	HLA-B57:02	RTHTGTPLL	0.9871	0.9147	9	18
KLF7-PARD3B	chr2	207988498	chr2	205912304	1110	HLA-C16:02	RTHTGTPLL	0.9854	0.9937	9	18
KLF7-PARD3B	chr2	207988498	chr2	205912304	1110	HLA-C03:06	RTHTGTPLL	0.9437	0.9906	9	18
KLF7-PARD3B	chr2	207988498	chr2	205912304	1110	HLA-A74:01	HTGTPLLVR	0.9367	0.884	11	20
KLF7-PARD3B	chr2	207988498	chr2	205912304	1110	HLA-B15:09	THTGTPLLV	0.9182	0.9	10	19
KLF7-PARD3B	chr2	207988498	chr2	205912304	1110	HLA-B15:73	RTHTGTPLL	0.906	0.942	9	18
KLF7-PARD3B	chr2	207988498	chr2	205912304	1110	HLA-B15:30	RTHTGTPLL	0.8829	0.9414	9	18
KLF7-PARD3B	chr2	207988498	chr2	205912304	1110	HLA-B48:05	RTHTGTPLL	0.8278	0.5516	9	18
KLF7-PARD3B	chr2	207988498	chr2	205912304	1110	HLA-B39:11	THTGTPLLV	0.8112	0.87	10	19
KLF7-PARD3B	chr2	207988498	chr2	205912304	1110	HLA-B15:09	QRTHTGTPL	0.7966	0.7992	8	17
KLF7-PARD3B	chr2	207988498	chr2	205912304	1110	HLA-A66:02	HTGTPLLVR	0.7891	0.8078	11	20
KLF7-PARD3B	chr2	207988498	chr2	205912304	1110	HLA-B07:13	RTHTGTPLL	0.7574	0.9283	9	18
KLF7-PARD3B	chr2	207988498	chr2	205912304	1110	HLA-C17:01	RTHTGTPLL	0.4795	0.9645	9	18
KLF7-PARD3B	chr2	207988498	chr2	205912304	1110	HLA-C07:04	THTGTPLLV	0.4132	0.9689	10	19
KLF7-PARD3B	chr2	207988498	chr2	205912304	1110	HLA-C06:06	THTGTPLLV	0.2011	0.9889	10	19
KLF7-PARD3B	chr2	207988498	chr2	205912304	1110	HLA-B40:21	RTHTGTPLL	0.1214	0.6679	9	18
KLF7-PARD3B	chr2	207988498	chr2	205912304	1110	HLA-B27:06	QRTHTGTPLL	0.9997	0.6368	8	18
KLF7-PARD3B	chr2	207988498	chr2	205912304	1110	HLA-C15:02	RTHTGTPLLV	0.9994	0.8569	9	19
KLF7-PARD3B	chr2	207988498	chr2	205912304	1110	HLA-B15:73	HQRTHTGTPL	0.9628	0.7671	7	17
KLF7-PARD3B	chr2	207988498	chr2	205912304	1110	HLA-A74:01	HTGTPLLVRR	0.9536	0.9086	11	21
KLF7-PARD3B	chr2	207988498	chr2	205912304	1110	HLA-B15:30	HQRTHTGTPL	0.9375	0.7741	7	17
KLF7-PARD3B	chr2	207988498	chr2	205912304	1110	HLA-A66:02	HTGTPLLVRR	0.8909	0.7807	11	21
KLF7-PARD3B	chr2	207988498	chr2	205912304	1110	HLA-A74:01	RTHTGTPLLVR	0.9984	0.7548	9	20
KLF7-PARD3B	chr2	208030191	chr2	205829875	479	HLA-A66:01	ETWQQLIAV	0.9985	0.7739	8	17
KLF7-PARD3B	chr2	208030191	chr2	205829875	479	HLA-A68:06	ETWQQLIAV	0.9961	0.7754	8	17
KLF7-PARD3B	chr2	208030191	chr2	205829875	479	HLA-A26:03	ETWQQLIAV	0.9946	0.7773	8	17
KLF7-PARD3B	chr2	208030191	chr2	205829875	479	HLA-B45:01	EETWQQLIA	0.9923	0.9481	7	16
KLF7-PARD3B	chr2	208030191	chr2	205829875	479	HLA-B50:02	EETWQQLIA	0.9805	0.6334	7	16
KLF7-PARD3B	chr2	208030191	chr2	205829875	479	HLA-A02:30	SLEETWQQL	0.9719	0.6399	5	14
KLF7-PARD3B	chr2	208030191	chr2	205829875	479	HLA-A02:24	SLEETWQQL	0.9719	0.6399	5	14
KLF7-PARD3B	chr2	208030191	chr2	205829875	479	HLA-A02:67	SLEETWQQL	0.9719	0.6399	5	14
KLF7-PARD3B	chr2	208030191	chr2	205829875	479	HLA-A02:60	SLEETWQQL	0.9703	0.6287	5	14
KLF7-PARD3B	chr2	208030191	chr2	205829875	479	HLA-A02:11	SLEETWQQL	0.966	0.666	5	14
KLF7-PARD3B	chr2	208030191	chr2	205829875	479	HLA-A26:02	ETWQQLIAV	0.9632	0.7842	8	17
KLF7-PARD3B	chr2	208030191	chr2	205829875	479	HLA-A02:22	SLEETWQQL	0.9627	0.5675	5	14
KLF7-PARD3B	chr2	208030191	chr2	205829875	479	HLA-A02:38	SLEETWQQL	0.9622	0.7965	5	14
KLF7-PARD3B	chr2	208030191	chr2	205829875	479	HLA-A02:16	SLEETWQQL	0.9574	0.5115	5	14
KLF7-PARD3B	chr2	208030191	chr2	205829875	479	HLA-A02:21	SLEETWQQL	0.9566	0.7517	5	14
KLF7-PARD3B	chr2	208030191	chr2	205829875	479	HLA-A02:04	SLEETWQQL	0.9453	0.6486	5	14
KLF7-PARD3B	chr2	208030191	chr2	205829875	479	HLA-A02:27	SLEETWQQL	0.942	0.6425	5	14
KLF7-PARD3B	chr2	208030191	chr2	205829875	479	HLA-A02:17	SLEETWQQL	0.9259	0.5647	5	14
KLF7-PARD3B	chr2	208030191	chr2	205829875	479	HLA-A02:35	SLEETWQQL	0.9126	0.6573	5	14
KLF7-PARD3B	chr2	208030191	chr2	205829875	479	HLA-A26:15	ETWQQLIAV	0.9068	0.8113	8	17
KLF7-PARD3B	chr2	208030191	chr2	205829875	479	HLA-A26:14	ETWQQLIAV	0.9068	0.8113	8	17
KLF7-PARD3B	chr2	208030191	chr2	205829875	479	HLA-A02:13	SLEETWQQL	0.8947	0.7552	5	14
KLF7-PARD3B	chr2	208030191	chr2	205829875	479	HLA-A02:29	SLEETWQQL	0.8485	0.6365	5	14
KLF7-PARD3B	chr2	208030191	chr2	205829875	479	HLA-A02:20	SLEETWQQL	0.8331	0.6443	5	14
KLF7-PARD3B	chr2	208030191	chr2	205829875	479	HLA-A24:14	TWQQLIAVF	0.8017	0.6109	9	18
KLF7-PARD3B	chr2	208030191	chr2	205829875	479	HLA-A02:19	SLEETWQQL	0.7837	0.5164	5	14
KLF7-PARD3B	chr2	208030191	chr2	205829875	479	HLA-B41:01	EETWQQLIA	0.3576	0.9717	7	16
KLF7-PARD3B	chr2	208030191	chr2	205829875	479	HLA-B50:01	EETWQQLIA	0.3335	0.801	7	16
KLF7-PARD3B	chr2	208030191	chr2	205829875	479	HLA-B13:01	SLEETWQQL	0.1669	0.9755	5	14
KLF7-PARD3B	chr2	208030191	chr2	205829875	479	HLA-B44:03	EETWQQLIAVF	0.9989	0.9347	7	18
KLF7-PARD3B	chr2	208030191	chr2	205829875	479	HLA-B35:03	LPSLEETWQQL	0.9875	0.7353	3	14
KLF7-PARD3B	chr2	208030191	chr2	205829875	479	HLA-B35:02	LPSLEETWQQL	0.963	0.9555	3	14
KLF7-PARD3B	chr2	208030191	chr2	205829875	479	HLA-B35:04	LPSLEETWQQL	0.963	0.9555	3	14
KLF7-PARD3B	chr2	208030191	chr2	205829875	479	HLA-C05:09	SLEETWQQL	0.9999	0.9511	5	14
KLF7-PARD3B	chr2	208030191	chr2	205829875	479	HLA-C04:07	SLEETWQQL	0.9998	0.9232	5	14
KLF7-PARD3B	chr2	208030191	chr2	205829875	479	HLA-C08:15	SLEETWQQL	0.9998	0.9774	5	14
KLF7-PARD3B	chr2	208030191	chr2	205829875	479	HLA-C04:10	SLEETWQQL	0.9998	0.9312	5	14
KLF7-PARD3B	chr2	208030191	chr2	205829875	479	HLA-C01:17	SLEETWQQL	0.9986	0.9678	5	14
KLF7-PARD3B	chr2	208030191	chr2	205829875	479	HLA-A02:07	SLEETWQQL	0.9724	0.6943	5	14
KLF7-PARD3B	chr2	208030191	chr2	205829875	479	HLA-A02:01	SLEETWQQL	0.9719	0.6399	5	14
KLF7-PARD3B	chr2	208030191	chr2	205829875	479	HLA-C04:06	SLEETWQQL	0.9568	0.9493	5	14
KLF7-PARD3B	chr2	208030191	chr2	205829875	479	HLA-B44:10	LEETWQQLI	0.9195	0.7151	6	15
KLF7-PARD3B	chr2	208030191	chr2	205829875	479	HLA-A26:01	ETWQQLIAV	0.9068	0.8113	8	17
KLF7-PARD3B	chr2	208030191	chr2	205829875	479	HLA-C04:14	SLEETWQQL	0.8989	0.9505	5	14
KLF7-PARD3B	chr2	208030191	chr2	205829875	479	HLA-B56:04	LPSLEETWQQL	0.9723	0.5659	3	14
KLF7-PARD3B	chr2	208030191	chr2	205829875	479	HLA-B35:12	LPSLEETWQQL	0.963	0.9555	3	14
KLF7-PARD3B	chr2	208030191	chr2	205829875	479	HLA-B39:10	LPSLEETWQQL	0.9019	0.9821	3	14
KLF7-PARD3B	chr2	208030191	chr2	205829875	479	HLA-B41:03	LEETWQQL	0.8741	0.8013	6	14
KLF7-PARD3B	chr2	208030191	chr2	205829875	479	HLA-C04:03	SLEETWQQL	0.9999	0.9228	5	14
KLF7-PARD3B	chr2	208030191	chr2	205829875	479	HLA-C05:01	SLEETWQQL	0.9999	0.9511	5	14
KLF7-PARD3B	chr2	208030191	chr2	205829875	479	HLA-C04:01	SLEETWQQL	0.9998	0.9232	5	14
KLF7-PARD3B	chr2	208030191	chr2	205829875	479	HLA-C08:02	SLEETWQQL	0.9998	0.9774	5	14
KLF7-PARD3B	chr2	208030191	chr2	205829875	479	HLA-C18:01	SLEETWQQL	0.9998	0.9256	5	14
KLF7-PARD3B	chr2	208030191	chr2	205829875	479	HLA-C01:03	SLEETWQQL	0.9997	0.9716	5	14
KLF7-PARD3B	chr2	208030191	chr2	205829875	479	HLA-A68:02	ETWQQLIAV	0.9989	0.7155	8	17
KLF7-PARD3B	chr2	208030191	chr2	205829875	479	HLA-A69:01	ETWQQLIAV	0.9971	0.7499	8	17
KLF7-PARD3B	chr2	208030191	chr2	205829875	479	HLA-A25:01	ETWQQLIAV	0.9635	0.9612	8	17
KLF7-PARD3B	chr2	208030191	chr2	205829875	479	HLA-A02:14	SLEETWQQL	0.9589	0.6977	5	14
KLF7-PARD3B	chr2	208030191	chr2	205829875	479	HLA-A02:06	SLEETWQQL	0.9566	0.7517	5	14
KLF7-PARD3B	chr2	208030191	chr2	205829875	479	HLA-A66:02	ETWQQLIAV	0.839	0.5807	8	17
KLF7-PARD3B	chr2	208030191	chr2	205829875	479	HLA-B50:04	EETWQQLIA	0.3335	0.801	7	16
KLF7-PARD3B	chr2	208030191	chr2	205829875	479	HLA-B50:05	EETWQQLIA	0.3335	0.801	7	16
KLF7-PARD3B	chr2	208030191	chr2	205829875	479	HLA-B15:73	SLEETWQQL	0.3061	0.9539	5	14
KLF7-PARD3B	chr2	208030191	chr2	205829875	479	HLA-B41:03	LEETWQQLI	0.2029	0.8011	6	15
KLF7-PARD3B	chr2	208030191	chr2	205829875	479	HLA-B07:13	SLEETWQQL	0.1649	0.795	5	14
KLF7-PARD3B	chr2	208030191	chr2	205829875	479	HLA-C14:02	TWQQLIAVF	0.1508	0.9704	9	18
KLF7-PARD3B	chr2	208030191	chr2	205829875	479	HLA-C14:03	TWQQLIAVF	0.1508	0.9704	9	18
KLF7-PARD3B	chr2	208030191	chr2	205829875	479	HLA-A25:01	ETWQQLIAVF	0.9615	0.8824	8	18
KLF7-PARD3B	chr2	208030191	chr2	205829875	479	HLA-A68:02	EETWQQLIAV	0.8537	0.618	7	17
KLF7-PARD3B	chr2	208030191	chr2	205829875	479	HLA-A69:01	EETWQQLIAV	0.7959	0.7083	7	17
KLF7-PARD3B	chr2	208030191	chr2	205829875	479	HLA-B44:26	EETWQQLIAVF	0.9989	0.9347	7	18
KLF7-PARD3B	chr2	208030191	chr2	205829875	479	HLA-B44:07	EETWQQLIAVF	0.9989	0.9347	7	18
KLF7-PARD3B	chr2	208030191	chr2	205829875	479	HLA-B44:13	EETWQQLIAVF	0.9989	0.9347	7	18
KLF7-PARD3B	chr2	208030191	chr2	205829875	479	HLA-B35:22	LPSLEETWQQL	0.9823	0.6442	3	14
KLF7-PARD3B	chr2	208030191	chr2	205829875	479	HLA-B18:03	EETWQQLIAVF	0.9809	0.7485	7	18
KLF7-PARD3B	chr2	208030191	chr2	205829875	479	HLA-B56:02	LPSLEETWQQL	0.9723	0.5659	3	14
KLF7-PARD3B	chr2	208030191	chr2	205829875	479	HLA-B35:09	LPSLEETWQQL	0.963	0.9555	3	14
KLF7-PARD3B	chr2	208030191	chr2	205829875	479	HLA-B55:04	LPSLEETWQQL	0.949	0.7023	3	14
KLF7-PARD3B	chr2	208030191	chr2	205829875	479	HLA-B67:01	LPSLEETWQQL	0.9091	0.9578	3	14

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Potential FusionNeoAntigen Information of KLF7-PARD3B in HLA II

KLF7-PARD3B_208030191_205829875.msa

Potential FusionNeoAntigen Information
* We used NetMHCIIpan v4.1 (%rank<0.5).

Fusion gene	Hchr	Hbp	Tgene	Tchr	Tbp	HLA II	FusionNeoAntigen peptide	Neoantigen start (at BP 13)	Neoantigen end (at BP 13)
KLF7-PARD3B	chr2	208030191	chr2	205829875	479	DRB1-1503	QQLIAVFEEQEPLHK	11	26

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Fusion breakpoint peptide structures of KLF7-PARD3B

3D structures of the fusion breakpoint peptide of 14AA sequence that have potential fusion neoantigens
* The minimum length of the amino acid sequence in RoseTTAFold is 14AA. Here, we predicted the 14AA fusion protein breakpoint sequence not the fusion neoantigen peptide, which is shorter than 14 AA.

File name	BPseq	Hgene	Tgene	Hchr	Hbp	Tchr	Tbp	AAlen
266	AHQRTHTGTPLLVR	KLF7	PARD3B	chr2	207988498	chr2	205912304	1110

File name	BPseq	Hgene	Tgene	Hchr	Hbp	Tchr	Tbp	AAlen
4887	LEETWQQLIAVFEE	KLF7	PARD3B	chr2	208030191	chr2	205829875	479

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Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D of KLF7-PARD3B

Virtual screening between 25 HLAs (from PDB) and FusionNeoAntigens
* We used Glide to predict the interaction between HLAs and neoantigens.

HLA allele	PDB ID	File name	BPseq	Docking score	Glide score
HLA-B14:02	3BVN	266	AHQRTHTGTPLLVR	-7.9962	-8.1096
HLA-B14:02	3BVN	266	AHQRTHTGTPLLVR	-5.70842	-6.74372
HLA-B52:01	3W39	266	AHQRTHTGTPLLVR	-6.83737	-6.95077
HLA-B52:01	3W39	266	AHQRTHTGTPLLVR	-4.4836	-5.5189
HLA-A11:01	4UQ2	266	AHQRTHTGTPLLVR	-10.0067	-10.1201
HLA-A11:01	4UQ2	266	AHQRTHTGTPLLVR	-9.03915	-10.0745
HLA-A24:02	5HGA	266	AHQRTHTGTPLLVR	-6.56204	-6.67544
HLA-A24:02	5HGA	266	AHQRTHTGTPLLVR	-5.42271	-6.45801
HLA-B44:05	3DX8	266	AHQRTHTGTPLLVR	-7.85648	-8.89178
HLA-B44:05	3DX8	266	AHQRTHTGTPLLVR	-5.3978	-5.5112
HLA-A02:01	6TDR	266	AHQRTHTGTPLLVR	-3.37154	-4.40684
HLA-B14:02	3BVN	4887	LEETWQQLIAVFEE	-7.15543	-7.26883
HLA-B14:02	3BVN	4887	LEETWQQLIAVFEE	-4.77435	-5.80965
HLA-B52:01	3W39	4887	LEETWQQLIAVFEE	-6.80875	-6.92215
HLA-B52:01	3W39	4887	LEETWQQLIAVFEE	-4.20386	-5.23916
HLA-A11:01	4UQ2	4887	LEETWQQLIAVFEE	-7.5194	-8.5547
HLA-A11:01	4UQ2	4887	LEETWQQLIAVFEE	-6.9601	-7.0735
HLA-A24:02	5HGA	4887	LEETWQQLIAVFEE	-7.52403	-7.63743
HLA-A24:02	5HGA	4887	LEETWQQLIAVFEE	-5.82433	-6.85963
HLA-B27:05	6PYJ	4887	LEETWQQLIAVFEE	-3.28285	-4.31815
HLA-B44:05	3DX8	4887	LEETWQQLIAVFEE	-5.91172	-6.94702
HLA-B44:05	3DX8	4887	LEETWQQLIAVFEE	-4.24346	-4.35686

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Vaccine Design for the FusionNeoAntigens of KLF7-PARD3B

mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-Is.

Fusion gene	Hchr	Hbp	Tchr	Tbp	Start in +/-13AA	End in +/-13AA	FusionNeoAntigen peptide sequence	FusionNeoAntigen RNA sequence
KLF7-PARD3B	chr2	207988498	chr2	205912304	10	18	THTGTPLL	CTCACACAGGCACTCCACTGCTGG
KLF7-PARD3B	chr2	207988498	chr2	205912304	10	19	THTGTPLLV	CTCACACAGGCACTCCACTGCTGGTGA
KLF7-PARD3B	chr2	207988498	chr2	205912304	11	20	HTGTPLLVR	ACACAGGCACTCCACTGCTGGTGAGGA
KLF7-PARD3B	chr2	207988498	chr2	205912304	11	21	HTGTPLLVRR	ACACAGGCACTCCACTGCTGGTGAGGAGAA
KLF7-PARD3B	chr2	207988498	chr2	205912304	6	17	AHQRTHTGTPL	CCCACCAGAGGACTCACACAGGCACTCCACTGC
KLF7-PARD3B	chr2	207988498	chr2	205912304	7	17	HQRTHTGTPL	ACCAGAGGACTCACACAGGCACTCCACTGC
KLF7-PARD3B	chr2	207988498	chr2	205912304	7	18	HQRTHTGTPLL	ACCAGAGGACTCACACAGGCACTCCACTGCTGG
KLF7-PARD3B	chr2	207988498	chr2	205912304	8	17	QRTHTGTPL	AGAGGACTCACACAGGCACTCCACTGC
KLF7-PARD3B	chr2	207988498	chr2	205912304	8	18	QRTHTGTPLL	AGAGGACTCACACAGGCACTCCACTGCTGG
KLF7-PARD3B	chr2	207988498	chr2	205912304	9	18	RTHTGTPLL	GGACTCACACAGGCACTCCACTGCTGG
KLF7-PARD3B	chr2	207988498	chr2	205912304	9	19	RTHTGTPLLV	GGACTCACACAGGCACTCCACTGCTGGTGA
KLF7-PARD3B	chr2	207988498	chr2	205912304	9	20	RTHTGTPLLVR	GGACTCACACAGGCACTCCACTGCTGGTGAGGA
KLF7-PARD3B	chr2	208030191	chr2	205829875	3	14	LPSLEETWQQL	TTACCATCCCTGGAGGAGACCTGGCAGCAGCTG
KLF7-PARD3B	chr2	208030191	chr2	205829875	5	14	SLEETWQQL	TCCCTGGAGGAGACCTGGCAGCAGCTG
KLF7-PARD3B	chr2	208030191	chr2	205829875	6	14	LEETWQQL	CTGGAGGAGACCTGGCAGCAGCTG
KLF7-PARD3B	chr2	208030191	chr2	205829875	6	15	LEETWQQLI	CTGGAGGAGACCTGGCAGCAGCTGATT
KLF7-PARD3B	chr2	208030191	chr2	205829875	7	16	EETWQQLIA	GAGGAGACCTGGCAGCAGCTGATTGCT
KLF7-PARD3B	chr2	208030191	chr2	205829875	7	17	EETWQQLIAV	GAGGAGACCTGGCAGCAGCTGATTGCTGTG
KLF7-PARD3B	chr2	208030191	chr2	205829875	7	18	EETWQQLIAVF	GAGGAGACCTGGCAGCAGCTGATTGCTGTGTTT
KLF7-PARD3B	chr2	208030191	chr2	205829875	8	17	ETWQQLIAV	GAGACCTGGCAGCAGCTGATTGCTGTG
KLF7-PARD3B	chr2	208030191	chr2	205829875	8	18	ETWQQLIAVF	GAGACCTGGCAGCAGCTGATTGCTGTGTTT
KLF7-PARD3B	chr2	208030191	chr2	205829875	9	18	TWQQLIAVF	ACCTGGCAGCAGCTGATTGCTGTGTTT

mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-IIs.

Fusion gene	Hchr	Hbp	Tchr	Tbp	Start in +/-13AA	End in +/-13AA	FusionNeoAntigen peptide	FusionNEoAntigen RNA sequence
KLF7-PARD3B	chr2	208030191	chr2	205829875	11	26	QQLIAVFEEQEPLHK	CAGCAGCTGATTGCTGTGTTTGAAGAACAAGAACCACTCCACAAG

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Information of the samples that have these potential fusion neoantigens of KLF7-PARD3B

These samples were reported as having these fusion breakpoints. For individual breakpoints, we checked the open reading frames considering multiple gene isoforms and chose the in-frame fusion genes only. Then, we made fusion protein sequences and predicted the fusion neoantigens. These fusion-positive samples may have these potential fusion neoantigens.

Cancer type	Fusion gene	Hchr	Hbp	Henst	Tchr	Tbp	Tenst	Sample
LUAD	KLF7-PARD3B	chr2	208030191	ENST00000309446	chr2	205829875	ENST00000349953	TCGA-78-7536-01A
SKCM	KLF7-PARD3B	chr2	207988498	ENST00000309446	chr2	205912304	ENST00000349953	TCGA-ER-A2NH-06A

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Potential target of CAR-T therapy development for KLF7-PARD3B

Predicted 3D structure. We used RoseTTAFold.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, to provide the retention of the transmembrane domain, we only show the protein feature retention information of those transmembrane features

* Minus value of BPloci means that the break point is located before the CDS.

- In-frame and retained 'Transmembrane'.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Subcellular localization prediction of the transmembrane domain retained fusion proteins
* We used DeepLoc 1.0. The order of the X-axis of the barplot is as follows: Entry_ID, Localization, Type, Nucleus, Cytoplasm, Extracellular, Mitochondrion, Cell_membrane, Endoplasmic_reticulum, Plastid, Golgi.apparatus, Lysosome.Vacuole, Peroxisome. Y-axis is the output score of DeepLoc. Clicking the image will open a new tab with a large image.

Hgene

Hchr

Hbp

Henst

Tgene

Tchr

Tbp

Tenst

DeepLoc result

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Related Drugs to KLF7-PARD3B

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to KLF7-PARD3B

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source

	Fusion Gene and Fusion Protein Summary
	Fusion Amino Acid Sequences (multiple BPs and multiple gene isoforms)
	Fusion Protein Breakpoint Sequences - (for the Screening of the FusionNeoAntigens)
	Potential FusionNeoAntigens in HLA I - (netMHCpan v4.1 + deepHLApan v1.1)
	Potential FusionNeoAntigens in HLA II - (netMHCIIpan v4.1)
	Fusion Breakpoint 14 AA Peptide Structure - (RoseTTAFold)
	Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D - (Glide)
	Vaccine Design for the FusionNeoAntigens (RNA/protein sequences)
	Potential target of CAR-T therapy development
	Information on the samples that have these potential fusion neoantigens
	Fusion Protein Targeting Drugs - (Manual Curation)
	Fusion Protein Related diseases - (Manual Curation)