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Center for Computational Systems Medicine
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Fusion Gene and Fusion Protein Summary

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Fusion Amino Acid Sequences (multiple BPs and multiple gene isoforms)

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Fusion Protein Breakpoint Sequences - (for the Screening of the FusionNeoAntigens)

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Potential FusionNeoAntigens in HLA I - (netMHCpan v4.1 + deepHLApan v1.1)

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Potential FusionNeoAntigens in HLA II - (netMHCIIpan v4.1)

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Fusion Breakpoint 14 AA Peptide Structure - (RoseTTAFold)

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Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D - (Glide)

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Vaccine Design for the FusionNeoAntigens (RNA/protein sequences)

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Potential target of CAR-T therapy development

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Information on the samples that have these potential fusion neoantigens

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Fusion Protein Targeting Drugs - (Manual Curation)

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Fusion Protein Related diseases - (Manual Curation)

Fusion Protein:LIPF-TMED6

Fusion Gene and Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: LIPF-TMED6
FusionPDB ID: 45651
FusionGDB2.0 ID: 45651
HgeneTgene
Gene symbol

LIPF

TMED6

Gene ID

8513

146456

Gene namelipase F, gastric typetransmembrane p24 trafficking protein 6
SynonymsGL|HGL|HLALPRO34237|SPLL9146|p24g5
Cytomap

10q23.31

16q22.1

Type of geneprotein-codingprotein-coding
Descriptiongastric triacylglycerol lipasegastric lipaselipase, gastrictransmembrane emp24 domain-containing protein 6p24 family protein gamma-5p24gamma5transmembrane emp24 protein transport domain containing 6
Modification date2020031320200313
UniProtAcc

P07098

Main function of 5'-partner protein: FUNCTION: Catalyzes the hydrolysis of triacylglycerols to yield free fatty acids, diacylglycerol, monoacylglycerol, and glycerol (PubMed:2243091, PubMed:10358049). Shows a preferential hydrolysis at the sn-3 position of triacylglycerol (PubMed:2243091). {ECO:0000269|PubMed:10358049, ECO:0000269|PubMed:2243091}.
.
Ensembl transtripts involved in fusion geneENST idsENST00000238983, ENST00000355843, 
ENST00000394375, ENST00000608620, 
ENST00000288025, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score14 X 28 X 4=15681 X 1 X 1=1
# samples 161
** MAII scorelog2(16/1568*10)=-3.29278174922785
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(1/1*10)=3.32192809488736
Fusion gene context

PubMed: LIPF [Title/Abstract] AND TMED6 [Title/Abstract] AND fusion [Title/Abstract]

Fusion neoantigen context

PubMed: LIPF [Title/Abstract] AND TMED6 [Title/Abstract] AND neoantigen [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)LIPF(90431722)-TMED6(69383554), # samples:1
Anticipated loss of major functional domain due to fusion event.LIPF-TMED6 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
LIPF-TMED6 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:90431722/chr16:69383554)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonRetention analysis results of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features, are available here.

check buttonFusion gene breakpoints across LIPF (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across TMED6 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Amino Acid Sequences


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000394375LIPFchr1090431722+ENST00000288025TMED6chr1669383554-1481812831321412
ENST00000608620LIPFchr1090431722+ENST00000288025TMED6chr1669383554-1301632621141359
ENST00000238983LIPFchr1090431722+ENST00000288025TMED6chr1669383554-1384715461224392
ENST00000355843LIPFchr1090431722+ENST00000288025TMED6chr1669383554-1365696661205379

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000394375ENST00000288025LIPFchr1090431722+TMED6chr1669383554-0.0005227750.9994772
ENST00000608620ENST00000288025LIPFchr1090431722+TMED6chr1669383554-0.0001672890.99983263
ENST00000238983ENST00000288025LIPFchr1090431722+TMED6chr1669383554-0.0002296780.99977034
ENST00000355843ENST00000288025LIPFchr1090431722+TMED6chr1669383554-0.0002252310.99977475

check button Predicted full-length fusion amino acid sequences. For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among all the predicted ones.

Get the fusion protein sequences from here.

Fusion protein sequence information is available in the fasta format.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

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Fusion Protein Breakpoint Sequences for LIPF-TMED6

check button +/-13 AA sequence from the breakpoints of the fusion protein sequences.
HgeneHchrHbpTgeneTchrTbpLength(fusion protein)BP in fusion proteinPeptide
LIPFchr1090431722TMED6chr1669383554632148VGHSQGTTIGFIAFSTNPSLAKRIKT
LIPFchr1090431722TMED6chr1669383554696168VGHSQGTTIGFIAFSTNPSLAKRIKT
LIPFchr1090431722TMED6chr1669383554715181VGHSQGTTIGFIAFSTNPSLAKRIKT
LIPFchr1090431722TMED6chr1669383554812201VGHSQGTTIGFIAFSTNPSLAKRIKT

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Potential FusionNeoAntigen Information of LIPF-TMED6 in HLA I

check button Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.
LIPF-TMED6_90431722_69383554.msa

check button Potential FusionNeoAntigen Information
* We used NetMHCpan v4.1 (%rank<0.5) and deepHLApan v1.1 (immunogenic score>0.5)
Fusion geneHchrHbpTgeneTchrTbpHLA IFusionNeoAntigen peptideBinding scoreImmunogenic scoreNeoantigen start (at BP 13)Neoantigen end (at BP 13)
LIPF-TMED6chr1090431722chr1669383554715HLA-B35:03IAFSTNPSL0.98850.84031120
LIPF-TMED6chr1090431722chr1669383554715HLA-B15:17IAFSTNPSL0.98820.74581120
LIPF-TMED6chr1090431722chr1669383554715HLA-B52:01IAFSTNPSL0.98220.76751120
LIPF-TMED6chr1090431722chr1669383554715HLA-B35:01IAFSTNPSL0.97330.77621120
LIPF-TMED6chr1090431722chr1669383554715HLA-B35:04IAFSTNPSL0.92080.88471120
LIPF-TMED6chr1090431722chr1669383554715HLA-B35:02IAFSTNPSL0.92080.88471120
LIPF-TMED6chr1090431722chr1669383554715HLA-A31:02AFSTNPSLAKR0.98820.65131223
LIPF-TMED6chr1090431722chr1669383554715HLA-A74:03AFSTNPSLAKR0.98460.70871223
LIPF-TMED6chr1090431722chr1669383554715HLA-A74:11AFSTNPSLAKR0.98460.70871223
LIPF-TMED6chr1090431722chr1669383554715HLA-A74:09AFSTNPSLAKR0.98460.70871223
LIPF-TMED6chr1090431722chr1669383554715HLA-C03:19IAFSTNPSL0.99970.98411120
LIPF-TMED6chr1090431722chr1669383554715HLA-C03:08IAFSTNPSL0.99970.86451120
LIPF-TMED6chr1090431722chr1669383554715HLA-C03:07IAFSTNPSL0.99960.97781120
LIPF-TMED6chr1090431722chr1669383554715HLA-C15:04IAFSTNPSL0.99950.881120
LIPF-TMED6chr1090431722chr1669383554715HLA-C15:06IAFSTNPSL0.9990.90641120
LIPF-TMED6chr1090431722chr1669383554715HLA-C04:06IAFSTNPSL0.9960.83421120
LIPF-TMED6chr1090431722chr1669383554715HLA-C08:13IAFSTNPSL0.99320.94961120
LIPF-TMED6chr1090431722chr1669383554715HLA-C08:04IAFSTNPSL0.99320.94961120
LIPF-TMED6chr1090431722chr1669383554715HLA-C06:03IAFSTNPSL0.98460.9941120
LIPF-TMED6chr1090431722chr1669383554715HLA-C12:04IAFSTNPSL0.98440.99371120
LIPF-TMED6chr1090431722chr1669383554715HLA-B51:07IAFSTNPSL0.98210.64681120
LIPF-TMED6chr1090431722chr1669383554715HLA-C12:12IAFSTNPSL0.98060.93191120
LIPF-TMED6chr1090431722chr1669383554715HLA-C07:13IAFSTNPSL0.95510.87681120
LIPF-TMED6chr1090431722chr1669383554715HLA-C03:14IAFSTNPSL0.95480.9691120
LIPF-TMED6chr1090431722chr1669383554715HLA-C08:03IAFSTNPSL0.94570.97381120
LIPF-TMED6chr1090431722chr1669383554715HLA-B35:12IAFSTNPSL0.92080.88471120
LIPF-TMED6chr1090431722chr1669383554715HLA-C07:29IAFSTNPSL0.91690.94431120
LIPF-TMED6chr1090431722chr1669383554715HLA-C02:06IAFSTNPSL0.85840.97061120
LIPF-TMED6chr1090431722chr1669383554715HLA-B39:10IAFSTNPSL0.79120.91831120
LIPF-TMED6chr1090431722chr1669383554715HLA-C01:30IAFSTNPSL0.6930.95511120
LIPF-TMED6chr1090431722chr1669383554715HLA-C01:17IAFSTNPSL0.54690.92461120
LIPF-TMED6chr1090431722chr1669383554715HLA-C03:08FIAFSTNPSL0.99740.91661020
LIPF-TMED6chr1090431722chr1669383554715HLA-C03:07FIAFSTNPSL0.99730.98271020
LIPF-TMED6chr1090431722chr1669383554715HLA-C03:19FIAFSTNPSL0.99630.9881020
LIPF-TMED6chr1090431722chr1669383554715HLA-A31:01AFSTNPSLAKR0.98990.59781223
LIPF-TMED6chr1090431722chr1669383554715HLA-C14:02AFSTNPSL0.88110.95251220
LIPF-TMED6chr1090431722chr1669383554715HLA-C14:03AFSTNPSL0.88110.95251220
LIPF-TMED6chr1090431722chr1669383554715HLA-C03:04IAFSTNPSL0.99970.98711120
LIPF-TMED6chr1090431722chr1669383554715HLA-C03:03IAFSTNPSL0.99970.98711120
LIPF-TMED6chr1090431722chr1669383554715HLA-C03:67IAFSTNPSL0.99960.9731120
LIPF-TMED6chr1090431722chr1669383554715HLA-C03:17IAFSTNPSL0.99950.96531120
LIPF-TMED6chr1090431722chr1669383554715HLA-C03:05IAFSTNPSL0.99950.90281120
LIPF-TMED6chr1090431722chr1669383554715HLA-C15:09IAFSTNPSL0.99950.881120
LIPF-TMED6chr1090431722chr1669383554715HLA-C03:02IAFSTNPSL0.99930.96221120
LIPF-TMED6chr1090431722chr1669383554715HLA-C15:05IAFSTNPSL0.99880.91741120
LIPF-TMED6chr1090431722chr1669383554715HLA-C15:02IAFSTNPSL0.99880.87311120
LIPF-TMED6chr1090431722chr1669383554715HLA-C16:04IAFSTNPSL0.99780.98421120
LIPF-TMED6chr1090431722chr1669383554715HLA-C12:02IAFSTNPSL0.99590.97251120
LIPF-TMED6chr1090431722chr1669383554715HLA-C04:04IAFSTNPSL0.99440.78481120
LIPF-TMED6chr1090431722chr1669383554715HLA-B35:11IAFSTNPSL0.99320.81541120
LIPF-TMED6chr1090431722chr1669383554715HLA-C12:03IAFSTNPSL0.99260.97921120
LIPF-TMED6chr1090431722chr1669383554715HLA-C03:06IAFSTNPSL0.98720.98551120
LIPF-TMED6chr1090431722chr1669383554715HLA-B35:13IAFSTNPSL0.98590.84891120
LIPF-TMED6chr1090431722chr1669383554715HLA-B35:23IAFSTNPSL0.97410.78921120
LIPF-TMED6chr1090431722chr1669383554715HLA-C16:01IAFSTNPSL0.97340.97061120
LIPF-TMED6chr1090431722chr1669383554715HLA-B35:77IAFSTNPSL0.97330.77621120
LIPF-TMED6chr1090431722chr1669383554715HLA-B35:30IAFSTNPSL0.97090.55411120
LIPF-TMED6chr1090431722chr1669383554715HLA-B35:17IAFSTNPSL0.97090.55411120
LIPF-TMED6chr1090431722chr1669383554715HLA-B35:24IAFSTNPSL0.9610.84621120
LIPF-TMED6chr1090431722chr1669383554715HLA-B35:43IAFSTNPSL0.95580.81151120
LIPF-TMED6chr1090431722chr1669383554715HLA-C16:02IAFSTNPSL0.9530.98281120
LIPF-TMED6chr1090431722chr1669383554715HLA-C08:01IAFSTNPSL0.94570.97381120
LIPF-TMED6chr1090431722chr1669383554715HLA-C07:04IAFSTNPSL0.94380.90861120
LIPF-TMED6chr1090431722chr1669383554715HLA-B35:09IAFSTNPSL0.92080.88471120
LIPF-TMED6chr1090431722chr1669383554715HLA-B15:73IAFSTNPSL0.91680.76421120
LIPF-TMED6chr1090431722chr1669383554715HLA-B15:30IAFSTNPSL0.90210.64081120
LIPF-TMED6chr1090431722chr1669383554715HLA-B07:13IAFSTNPSL0.8540.80851120
LIPF-TMED6chr1090431722chr1669383554715HLA-C02:02IAFSTNPSL0.85050.97531120
LIPF-TMED6chr1090431722chr1669383554715HLA-C02:10IAFSTNPSL0.85050.97531120
LIPF-TMED6chr1090431722chr1669383554715HLA-C17:01IAFSTNPSL0.6410.89191120
LIPF-TMED6chr1090431722chr1669383554715HLA-C01:02IAFSTNPSL0.53760.92171120
LIPF-TMED6chr1090431722chr1669383554715HLA-C01:03IAFSTNPSL0.42980.87321120
LIPF-TMED6chr1090431722chr1669383554715HLA-C03:03FIAFSTNPSL0.99820.98981020
LIPF-TMED6chr1090431722chr1669383554715HLA-C03:04FIAFSTNPSL0.99820.98981020
LIPF-TMED6chr1090431722chr1669383554715HLA-C03:05FIAFSTNPSL0.99630.9241020
LIPF-TMED6chr1090431722chr1669383554715HLA-C03:17FIAFSTNPSL0.99560.96681020
LIPF-TMED6chr1090431722chr1669383554715HLA-C03:06FIAFSTNPSL0.99080.98921020
LIPF-TMED6chr1090431722chr1669383554715HLA-B35:13FIAFSTNPSL0.95460.8971020
LIPF-TMED6chr1090431722chr1669383554715HLA-A74:01AFSTNPSLAKR0.98460.70871223

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Potential FusionNeoAntigen Information of LIPF-TMED6 in HLA II

check button Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.
LIPF-TMED6_90431722_69383554.msa

check button Potential FusionNeoAntigen Information
* We used NetMHCIIpan v4.1 (%rank<0.5).
Fusion geneHchrHbpTgeneTchrTbpHLA IIFusionNeoAntigen peptideNeoantigen start (at BP 13)Neoantigen end (at BP 13)
LIPF-TMED6chr1090431722chr1669383554715DRB1-0103TIGFIAFSTNPSLAK722
LIPF-TMED6chr1090431722chr1669383554715DRB1-0109TIGFIAFSTNPSLAK722
LIPF-TMED6chr1090431722chr1669383554715DRB1-0113TIGFIAFSTNPSLAK722
LIPF-TMED6chr1090431722chr1669383554715DRB1-0115TIGFIAFSTNPSLAK722
LIPF-TMED6chr1090431722chr1669383554715DRB1-0401TIGFIAFSTNPSLAK722
LIPF-TMED6chr1090431722chr1669383554715DRB1-0401TTIGFIAFSTNPSLA621
LIPF-TMED6chr1090431722chr1669383554715DRB1-0401IGFIAFSTNPSLAKR823
LIPF-TMED6chr1090431722chr1669383554715DRB1-0401GTTIGFIAFSTNPSL520
LIPF-TMED6chr1090431722chr1669383554715DRB1-0403TIGFIAFSTNPSLAK722
LIPF-TMED6chr1090431722chr1669383554715DRB1-0403TTIGFIAFSTNPSLA621
LIPF-TMED6chr1090431722chr1669383554715DRB1-0405TIGFIAFSTNPSLAK722
LIPF-TMED6chr1090431722chr1669383554715DRB1-0405TTIGFIAFSTNPSLA621
LIPF-TMED6chr1090431722chr1669383554715DRB1-0407TIGFIAFSTNPSLAK722
LIPF-TMED6chr1090431722chr1669383554715DRB1-0407TTIGFIAFSTNPSLA621
LIPF-TMED6chr1090431722chr1669383554715DRB1-0407IGFIAFSTNPSLAKR823
LIPF-TMED6chr1090431722chr1669383554715DRB1-0407GTTIGFIAFSTNPSL520
LIPF-TMED6chr1090431722chr1669383554715DRB1-0409TIGFIAFSTNPSLAK722
LIPF-TMED6chr1090431722chr1669383554715DRB1-0415TIGFIAFSTNPSLAK722
LIPF-TMED6chr1090431722chr1669383554715DRB1-0415TTIGFIAFSTNPSLA621
LIPF-TMED6chr1090431722chr1669383554715DRB1-0417TIGFIAFSTNPSLAK722
LIPF-TMED6chr1090431722chr1669383554715DRB1-0417TTIGFIAFSTNPSLA621
LIPF-TMED6chr1090431722chr1669383554715DRB1-0419TIGFIAFSTNPSLAK722
LIPF-TMED6chr1090431722chr1669383554715DRB1-0419TTIGFIAFSTNPSLA621
LIPF-TMED6chr1090431722chr1669383554715DRB1-0419IGFIAFSTNPSLAKR823
LIPF-TMED6chr1090431722chr1669383554715DRB1-0419GTTIGFIAFSTNPSL520
LIPF-TMED6chr1090431722chr1669383554715DRB1-0424TIGFIAFSTNPSLAK722
LIPF-TMED6chr1090431722chr1669383554715DRB1-0424TTIGFIAFSTNPSLA621
LIPF-TMED6chr1090431722chr1669383554715DRB1-0424GTTIGFIAFSTNPSL520
LIPF-TMED6chr1090431722chr1669383554715DRB1-0424IGFIAFSTNPSLAKR823
LIPF-TMED6chr1090431722chr1669383554715DRB1-0427TIGFIAFSTNPSLAK722
LIPF-TMED6chr1090431722chr1669383554715DRB1-0427TTIGFIAFSTNPSLA621
LIPF-TMED6chr1090431722chr1669383554715DRB1-0427IGFIAFSTNPSLAKR823
LIPF-TMED6chr1090431722chr1669383554715DRB1-0429TIGFIAFSTNPSLAK722
LIPF-TMED6chr1090431722chr1669383554715DRB1-0429TTIGFIAFSTNPSLA621
LIPF-TMED6chr1090431722chr1669383554715DRB1-0430TIGFIAFSTNPSLAK722
LIPF-TMED6chr1090431722chr1669383554715DRB1-0430TTIGFIAFSTNPSLA621
LIPF-TMED6chr1090431722chr1669383554715DRB1-0431TIGFIAFSTNPSLAK722
LIPF-TMED6chr1090431722chr1669383554715DRB1-0431TTIGFIAFSTNPSLA621
LIPF-TMED6chr1090431722chr1669383554715DRB1-0431IGFIAFSTNPSLAKR823
LIPF-TMED6chr1090431722chr1669383554715DRB1-0431GTTIGFIAFSTNPSL520
LIPF-TMED6chr1090431722chr1669383554715DRB1-0433TIGFIAFSTNPSLAK722
LIPF-TMED6chr1090431722chr1669383554715DRB1-0433TTIGFIAFSTNPSLA621
LIPF-TMED6chr1090431722chr1669383554715DRB1-0433IGFIAFSTNPSLAKR823
LIPF-TMED6chr1090431722chr1669383554715DRB1-0433GTTIGFIAFSTNPSL520
LIPF-TMED6chr1090431722chr1669383554715DRB1-0434TIGFIAFSTNPSLAK722
LIPF-TMED6chr1090431722chr1669383554715DRB1-0434TTIGFIAFSTNPSLA621
LIPF-TMED6chr1090431722chr1669383554715DRB1-0434IGFIAFSTNPSLAKR823
LIPF-TMED6chr1090431722chr1669383554715DRB1-0435TIGFIAFSTNPSLAK722
LIPF-TMED6chr1090431722chr1669383554715DRB1-0435TTIGFIAFSTNPSLA621
LIPF-TMED6chr1090431722chr1669383554715DRB1-0435IGFIAFSTNPSLAKR823
LIPF-TMED6chr1090431722chr1669383554715DRB1-0435GTTIGFIAFSTNPSL520
LIPF-TMED6chr1090431722chr1669383554715DRB1-0436TIGFIAFSTNPSLAK722
LIPF-TMED6chr1090431722chr1669383554715DRB1-0436TTIGFIAFSTNPSLA621
LIPF-TMED6chr1090431722chr1669383554715DRB1-0437TIGFIAFSTNPSLAK722
LIPF-TMED6chr1090431722chr1669383554715DRB1-0438TIGFIAFSTNPSLAK722
LIPF-TMED6chr1090431722chr1669383554715DRB1-0438TTIGFIAFSTNPSLA621
LIPF-TMED6chr1090431722chr1669383554715DRB1-0438IGFIAFSTNPSLAKR823
LIPF-TMED6chr1090431722chr1669383554715DRB1-0438GTTIGFIAFSTNPSL520
LIPF-TMED6chr1090431722chr1669383554715DRB1-0439TIGFIAFSTNPSLAK722
LIPF-TMED6chr1090431722chr1669383554715DRB1-0439TTIGFIAFSTNPSLA621
LIPF-TMED6chr1090431722chr1669383554715DRB1-0441TIGFIAFSTNPSLAK722
LIPF-TMED6chr1090431722chr1669383554715DRB1-0441TTIGFIAFSTNPSLA621
LIPF-TMED6chr1090431722chr1669383554715DRB1-0442TIGFIAFSTNPSLAK722
LIPF-TMED6chr1090431722chr1669383554715DRB1-0443TIGFIAFSTNPSLAK722
LIPF-TMED6chr1090431722chr1669383554715DRB1-0443TTIGFIAFSTNPSLA621
LIPF-TMED6chr1090431722chr1669383554715DRB1-0443IGFIAFSTNPSLAKR823
LIPF-TMED6chr1090431722chr1669383554715DRB1-0443GTTIGFIAFSTNPSL520
LIPF-TMED6chr1090431722chr1669383554715DRB1-0444TIGFIAFSTNPSLAK722
LIPF-TMED6chr1090431722chr1669383554715DRB1-0445TIGFIAFSTNPSLAK722
LIPF-TMED6chr1090431722chr1669383554715DRB1-0445TTIGFIAFSTNPSLA621
LIPF-TMED6chr1090431722chr1669383554715DRB1-0446TIGFIAFSTNPSLAK722
LIPF-TMED6chr1090431722chr1669383554715DRB1-0446TTIGFIAFSTNPSLA621
LIPF-TMED6chr1090431722chr1669383554715DRB1-0447TIGFIAFSTNPSLAK722
LIPF-TMED6chr1090431722chr1669383554715DRB1-0447TTIGFIAFSTNPSLA621
LIPF-TMED6chr1090431722chr1669383554715DRB1-0447IGFIAFSTNPSLAKR823
LIPF-TMED6chr1090431722chr1669383554715DRB1-0447GTTIGFIAFSTNPSL520
LIPF-TMED6chr1090431722chr1669383554715DRB1-0448TIGFIAFSTNPSLAK722
LIPF-TMED6chr1090431722chr1669383554715DRB1-0448TTIGFIAFSTNPSLA621
LIPF-TMED6chr1090431722chr1669383554715DRB1-0449TIGFIAFSTNPSLAK722
LIPF-TMED6chr1090431722chr1669383554715DRB1-0449TTIGFIAFSTNPSLA621
LIPF-TMED6chr1090431722chr1669383554715DRB1-0450TIGFIAFSTNPSLAK722
LIPF-TMED6chr1090431722chr1669383554715DRB1-0450TTIGFIAFSTNPSLA621
LIPF-TMED6chr1090431722chr1669383554715DRB1-0451TIGFIAFSTNPSLAK722
LIPF-TMED6chr1090431722chr1669383554715DRB1-0451TTIGFIAFSTNPSLA621
LIPF-TMED6chr1090431722chr1669383554715DRB1-0452TIGFIAFSTNPSLAK722
LIPF-TMED6chr1090431722chr1669383554715DRB1-0452TTIGFIAFSTNPSLA621
LIPF-TMED6chr1090431722chr1669383554715DRB1-0453TIGFIAFSTNPSLAK722
LIPF-TMED6chr1090431722chr1669383554715DRB1-0453TTIGFIAFSTNPSLA621
LIPF-TMED6chr1090431722chr1669383554715DRB1-0454TIGFIAFSTNPSLAK722
LIPF-TMED6chr1090431722chr1669383554715DRB1-0454TTIGFIAFSTNPSLA621
LIPF-TMED6chr1090431722chr1669383554715DRB1-0454IGFIAFSTNPSLAKR823
LIPF-TMED6chr1090431722chr1669383554715DRB1-0454GTTIGFIAFSTNPSL520
LIPF-TMED6chr1090431722chr1669383554715DRB1-0455TIGFIAFSTNPSLAK722
LIPF-TMED6chr1090431722chr1669383554715DRB1-0456TIGFIAFSTNPSLAK722
LIPF-TMED6chr1090431722chr1669383554715DRB1-0457TIGFIAFSTNPSLAK722
LIPF-TMED6chr1090431722chr1669383554715DRB1-0457TTIGFIAFSTNPSLA621
LIPF-TMED6chr1090431722chr1669383554715DRB1-0458TIGFIAFSTNPSLAK722
LIPF-TMED6chr1090431722chr1669383554715DRB1-0458TTIGFIAFSTNPSLA621
LIPF-TMED6chr1090431722chr1669383554715DRB1-0459TIGFIAFSTNPSLAK722
LIPF-TMED6chr1090431722chr1669383554715DRB1-0459TTIGFIAFSTNPSLA621
LIPF-TMED6chr1090431722chr1669383554715DRB1-0459IGFIAFSTNPSLAKR823
LIPF-TMED6chr1090431722chr1669383554715DRB1-0460TIGFIAFSTNPSLAK722
LIPF-TMED6chr1090431722chr1669383554715DRB1-0460TTIGFIAFSTNPSLA621
LIPF-TMED6chr1090431722chr1669383554715DRB1-0461TIGFIAFSTNPSLAK722
LIPF-TMED6chr1090431722chr1669383554715DRB1-0461TTIGFIAFSTNPSLA621
LIPF-TMED6chr1090431722chr1669383554715DRB1-0461IGFIAFSTNPSLAKR823
LIPF-TMED6chr1090431722chr1669383554715DRB1-0461GTTIGFIAFSTNPSL520
LIPF-TMED6chr1090431722chr1669383554715DRB1-0462TIGFIAFSTNPSLAK722
LIPF-TMED6chr1090431722chr1669383554715DRB1-0462TTIGFIAFSTNPSLA621
LIPF-TMED6chr1090431722chr1669383554715DRB1-0463TIGFIAFSTNPSLAK722
LIPF-TMED6chr1090431722chr1669383554715DRB1-0463TTIGFIAFSTNPSLA621
LIPF-TMED6chr1090431722chr1669383554715DRB1-0463IGFIAFSTNPSLAKR823
LIPF-TMED6chr1090431722chr1669383554715DRB1-0463GTTIGFIAFSTNPSL520
LIPF-TMED6chr1090431722chr1669383554715DRB1-0464TIGFIAFSTNPSLAK722
LIPF-TMED6chr1090431722chr1669383554715DRB1-0464TTIGFIAFSTNPSLA621
LIPF-TMED6chr1090431722chr1669383554715DRB1-0464IGFIAFSTNPSLAKR823
LIPF-TMED6chr1090431722chr1669383554715DRB1-0465TIGFIAFSTNPSLAK722
LIPF-TMED6chr1090431722chr1669383554715DRB1-0465TTIGFIAFSTNPSLA621
LIPF-TMED6chr1090431722chr1669383554715DRB1-0465IGFIAFSTNPSLAKR823
LIPF-TMED6chr1090431722chr1669383554715DRB1-0465GTTIGFIAFSTNPSL520
LIPF-TMED6chr1090431722chr1669383554715DRB1-0466TIGFIAFSTNPSLAK722
LIPF-TMED6chr1090431722chr1669383554715DRB1-0469TIGFIAFSTNPSLAK722
LIPF-TMED6chr1090431722chr1669383554715DRB1-0469TTIGFIAFSTNPSLA621
LIPF-TMED6chr1090431722chr1669383554715DRB1-0469IGFIAFSTNPSLAKR823
LIPF-TMED6chr1090431722chr1669383554715DRB1-0470TIGFIAFSTNPSLAK722
LIPF-TMED6chr1090431722chr1669383554715DRB1-0471TIGFIAFSTNPSLAK722
LIPF-TMED6chr1090431722chr1669383554715DRB1-0471TTIGFIAFSTNPSLA621
LIPF-TMED6chr1090431722chr1669383554715DRB1-0472TIGFIAFSTNPSLAK722
LIPF-TMED6chr1090431722chr1669383554715DRB1-0472TTIGFIAFSTNPSLA621
LIPF-TMED6chr1090431722chr1669383554715DRB1-0473TIGFIAFSTNPSLAK722
LIPF-TMED6chr1090431722chr1669383554715DRB1-0473TTIGFIAFSTNPSLA621
LIPF-TMED6chr1090431722chr1669383554715DRB1-0473IGFIAFSTNPSLAKR823
LIPF-TMED6chr1090431722chr1669383554715DRB1-0474TIGFIAFSTNPSLAK722
LIPF-TMED6chr1090431722chr1669383554715DRB1-0474TTIGFIAFSTNPSLA621
LIPF-TMED6chr1090431722chr1669383554715DRB1-0474IGFIAFSTNPSLAKR823
LIPF-TMED6chr1090431722chr1669383554715DRB1-0474GTTIGFIAFSTNPSL520
LIPF-TMED6chr1090431722chr1669383554715DRB1-0475TIGFIAFSTNPSLAK722
LIPF-TMED6chr1090431722chr1669383554715DRB1-0475TTIGFIAFSTNPSLA621
LIPF-TMED6chr1090431722chr1669383554715DRB1-0475IGFIAFSTNPSLAKR823
LIPF-TMED6chr1090431722chr1669383554715DRB1-0475GTTIGFIAFSTNPSL520
LIPF-TMED6chr1090431722chr1669383554715DRB1-0476TIGFIAFSTNPSLAK722
LIPF-TMED6chr1090431722chr1669383554715DRB1-0476TTIGFIAFSTNPSLA621
LIPF-TMED6chr1090431722chr1669383554715DRB1-0476IGFIAFSTNPSLAKR823
LIPF-TMED6chr1090431722chr1669383554715DRB1-0476GTTIGFIAFSTNPSL520
LIPF-TMED6chr1090431722chr1669383554715DRB1-0477TIGFIAFSTNPSLAK722
LIPF-TMED6chr1090431722chr1669383554715DRB1-0477TTIGFIAFSTNPSLA621
LIPF-TMED6chr1090431722chr1669383554715DRB1-0478TIGFIAFSTNPSLAK722
LIPF-TMED6chr1090431722chr1669383554715DRB1-0478TTIGFIAFSTNPSLA621
LIPF-TMED6chr1090431722chr1669383554715DRB1-0478IGFIAFSTNPSLAKR823
LIPF-TMED6chr1090431722chr1669383554715DRB1-0479TIGFIAFSTNPSLAK722
LIPF-TMED6chr1090431722chr1669383554715DRB1-0479TTIGFIAFSTNPSLA621
LIPF-TMED6chr1090431722chr1669383554715DRB1-0480TIGFIAFSTNPSLAK722
LIPF-TMED6chr1090431722chr1669383554715DRB1-0480TTIGFIAFSTNPSLA621
LIPF-TMED6chr1090431722chr1669383554715DRB1-0480GTTIGFIAFSTNPSL520
LIPF-TMED6chr1090431722chr1669383554715DRB1-0480IGFIAFSTNPSLAKR823
LIPF-TMED6chr1090431722chr1669383554715DRB1-0482TIGFIAFSTNPSLAK722
LIPF-TMED6chr1090431722chr1669383554715DRB1-0482TTIGFIAFSTNPSLA621
LIPF-TMED6chr1090431722chr1669383554715DRB1-0482GTTIGFIAFSTNPSL520
LIPF-TMED6chr1090431722chr1669383554715DRB1-0482IGFIAFSTNPSLAKR823
LIPF-TMED6chr1090431722chr1669383554715DRB1-0483TIGFIAFSTNPSLAK722
LIPF-TMED6chr1090431722chr1669383554715DRB1-0483TTIGFIAFSTNPSLA621
LIPF-TMED6chr1090431722chr1669383554715DRB1-0484TIGFIAFSTNPSLAK722
LIPF-TMED6chr1090431722chr1669383554715DRB1-0484TTIGFIAFSTNPSLA621
LIPF-TMED6chr1090431722chr1669383554715DRB1-0485TIGFIAFSTNPSLAK722
LIPF-TMED6chr1090431722chr1669383554715DRB1-0485TTIGFIAFSTNPSLA621
LIPF-TMED6chr1090431722chr1669383554715DRB1-0486TIGFIAFSTNPSLAK722
LIPF-TMED6chr1090431722chr1669383554715DRB1-0486TTIGFIAFSTNPSLA621
LIPF-TMED6chr1090431722chr1669383554715DRB1-0486GTTIGFIAFSTNPSL520
LIPF-TMED6chr1090431722chr1669383554715DRB1-0486IGFIAFSTNPSLAKR823
LIPF-TMED6chr1090431722chr1669383554715DRB1-0487TIGFIAFSTNPSLAK722
LIPF-TMED6chr1090431722chr1669383554715DRB1-0487TTIGFIAFSTNPSLA621
LIPF-TMED6chr1090431722chr1669383554715DRB1-0488TIGFIAFSTNPSLAK722
LIPF-TMED6chr1090431722chr1669383554715DRB1-0488TTIGFIAFSTNPSLA621
LIPF-TMED6chr1090431722chr1669383554715DRB1-0488IGFIAFSTNPSLAKR823
LIPF-TMED6chr1090431722chr1669383554715DRB1-0489TIGFIAFSTNPSLAK722
LIPF-TMED6chr1090431722chr1669383554715DRB1-0489TTIGFIAFSTNPSLA621
LIPF-TMED6chr1090431722chr1669383554715DRB1-0802TIGFIAFSTNPSLAK722
LIPF-TMED6chr1090431722chr1669383554715DRB1-0803TIGFIAFSTNPSLAK722
LIPF-TMED6chr1090431722chr1669383554715DRB1-0803TTIGFIAFSTNPSLA621
LIPF-TMED6chr1090431722chr1669383554715DRB1-0807TIGFIAFSTNPSLAK722
LIPF-TMED6chr1090431722chr1669383554715DRB1-0809TIGFIAFSTNPSLAK722
LIPF-TMED6chr1090431722chr1669383554715DRB1-0813TIGFIAFSTNPSLAK722
LIPF-TMED6chr1090431722chr1669383554715DRB1-0813TTIGFIAFSTNPSLA621
LIPF-TMED6chr1090431722chr1669383554715DRB1-0814TIGFIAFSTNPSLAK722
LIPF-TMED6chr1090431722chr1669383554715DRB1-0814TTIGFIAFSTNPSLA621
LIPF-TMED6chr1090431722chr1669383554715DRB1-0815TIGFIAFSTNPSLAK722
LIPF-TMED6chr1090431722chr1669383554715DRB1-0815TTIGFIAFSTNPSLA621
LIPF-TMED6chr1090431722chr1669383554715DRB1-0815IGFIAFSTNPSLAKR823
LIPF-TMED6chr1090431722chr1669383554715DRB1-0819TIGFIAFSTNPSLAK722
LIPF-TMED6chr1090431722chr1669383554715DRB1-0819TTIGFIAFSTNPSLA621
LIPF-TMED6chr1090431722chr1669383554715DRB1-0821TIGFIAFSTNPSLAK722
LIPF-TMED6chr1090431722chr1669383554715DRB1-0823TIGFIAFSTNPSLAK722
LIPF-TMED6chr1090431722chr1669383554715DRB1-0823TTIGFIAFSTNPSLA621
LIPF-TMED6chr1090431722chr1669383554715DRB1-0824TIGFIAFSTNPSLAK722
LIPF-TMED6chr1090431722chr1669383554715DRB1-0825TIGFIAFSTNPSLAK722
LIPF-TMED6chr1090431722chr1669383554715DRB1-0827TIGFIAFSTNPSLAK722
LIPF-TMED6chr1090431722chr1669383554715DRB1-0827TTIGFIAFSTNPSLA621
LIPF-TMED6chr1090431722chr1669383554715DRB1-0830TIGFIAFSTNPSLAK722
LIPF-TMED6chr1090431722chr1669383554715DRB1-0830TTIGFIAFSTNPSLA621
LIPF-TMED6chr1090431722chr1669383554715DRB1-0830IGFIAFSTNPSLAKR823
LIPF-TMED6chr1090431722chr1669383554715DRB1-0832TIGFIAFSTNPSLAK722
LIPF-TMED6chr1090431722chr1669383554715DRB1-0833TIGFIAFSTNPSLAK722
LIPF-TMED6chr1090431722chr1669383554715DRB1-0833TTIGFIAFSTNPSLA621
LIPF-TMED6chr1090431722chr1669383554715DRB1-0834TIGFIAFSTNPSLAK722
LIPF-TMED6chr1090431722chr1669383554715DRB1-0834TTIGFIAFSTNPSLA621
LIPF-TMED6chr1090431722chr1669383554715DRB1-0835TIGFIAFSTNPSLAK722
LIPF-TMED6chr1090431722chr1669383554715DRB1-0835TTIGFIAFSTNPSLA621
LIPF-TMED6chr1090431722chr1669383554715DRB1-0836TIGFIAFSTNPSLAK722
LIPF-TMED6chr1090431722chr1669383554715DRB1-0836TTIGFIAFSTNPSLA621
LIPF-TMED6chr1090431722chr1669383554715DRB1-0837TIGFIAFSTNPSLAK722
LIPF-TMED6chr1090431722chr1669383554715DRB1-0837TTIGFIAFSTNPSLA621
LIPF-TMED6chr1090431722chr1669383554715DRB1-0838TIGFIAFSTNPSLAK722
LIPF-TMED6chr1090431722chr1669383554715DRB1-0838TTIGFIAFSTNPSLA621
LIPF-TMED6chr1090431722chr1669383554715DRB1-0902TIGFIAFSTNPSLAK722
LIPF-TMED6chr1090431722chr1669383554715DRB1-0908TIGFIAFSTNPSLAK722
LIPF-TMED6chr1090431722chr1669383554715DRB1-1001TIGFIAFSTNPSLAK722
LIPF-TMED6chr1090431722chr1669383554715DRB1-1003TIGFIAFSTNPSLAK722
LIPF-TMED6chr1090431722chr1669383554715DRB1-1105TIGFIAFSTNPSLAK722
LIPF-TMED6chr1090431722chr1669383554715DRB1-1119TIGFIAFSTNPSLAK722
LIPF-TMED6chr1090431722chr1669383554715DRB1-1130TIGFIAFSTNPSLAK722
LIPF-TMED6chr1090431722chr1669383554715DRB1-1130TTIGFIAFSTNPSLA621
LIPF-TMED6chr1090431722chr1669383554715DRB1-1131TIGFIAFSTNPSLAK722
LIPF-TMED6chr1090431722chr1669383554715DRB1-1145TIGFIAFSTNPSLAK722
LIPF-TMED6chr1090431722chr1669383554715DRB1-1164TIGFIAFSTNPSLAK722
LIPF-TMED6chr1090431722chr1669383554715DRB1-1169TIGFIAFSTNPSLAK722
LIPF-TMED6chr1090431722chr1669383554715DRB1-1182TIGFIAFSTNPSLAK722
LIPF-TMED6chr1090431722chr1669383554715DRB1-1182TTIGFIAFSTNPSLA621
LIPF-TMED6chr1090431722chr1669383554715DRB1-1182IGFIAFSTNPSLAKR823
LIPF-TMED6chr1090431722chr1669383554715DRB1-1326TIGFIAFSTNPSLAK722
LIPF-TMED6chr1090431722chr1669383554715DRB1-1336TIGFIAFSTNPSLAK722
LIPF-TMED6chr1090431722chr1669383554715DRB1-1367TIGFIAFSTNPSLAK722
LIPF-TMED6chr1090431722chr1669383554715DRB1-1367TTIGFIAFSTNPSLA621
LIPF-TMED6chr1090431722chr1669383554715DRB1-1367IGFIAFSTNPSLAKR823
LIPF-TMED6chr1090431722chr1669383554715DRB1-1382TIGFIAFSTNPSLAK722
LIPF-TMED6chr1090431722chr1669383554715DRB1-1386TIGFIAFSTNPSLAK722
LIPF-TMED6chr1090431722chr1669383554715DRB1-1402TIGFIAFSTNPSLAK722
LIPF-TMED6chr1090431722chr1669383554715DRB1-1403TIGFIAFSTNPSLAK722
LIPF-TMED6chr1090431722chr1669383554715DRB1-1409TIGFIAFSTNPSLAK722
LIPF-TMED6chr1090431722chr1669383554715DRB1-1410TIGFIAFSTNPSLAK722
LIPF-TMED6chr1090431722chr1669383554715DRB1-1410IGFIAFSTNPSLAKR823
LIPF-TMED6chr1090431722chr1669383554715DRB1-1424TIGFIAFSTNPSLAK722
LIPF-TMED6chr1090431722chr1669383554715DRB1-1424TTIGFIAFSTNPSLA621
LIPF-TMED6chr1090431722chr1669383554715DRB1-1424IGFIAFSTNPSLAKR823
LIPF-TMED6chr1090431722chr1669383554715DRB1-1427TIGFIAFSTNPSLAK722
LIPF-TMED6chr1090431722chr1669383554715DRB1-1430TIGFIAFSTNPSLAK722
LIPF-TMED6chr1090431722chr1669383554715DRB1-1439IGFIAFSTNPSLAKR823
LIPF-TMED6chr1090431722chr1669383554715DRB1-1440TIGFIAFSTNPSLAK722
LIPF-TMED6chr1090431722chr1669383554715DRB1-1441TIGFIAFSTNPSLAK722
LIPF-TMED6chr1090431722chr1669383554715DRB1-1446TIGFIAFSTNPSLAK722
LIPF-TMED6chr1090431722chr1669383554715DRB1-1446TTIGFIAFSTNPSLA621
LIPF-TMED6chr1090431722chr1669383554715DRB1-1446IGFIAFSTNPSLAKR823
LIPF-TMED6chr1090431722chr1669383554715DRB1-1451TIGFIAFSTNPSLAK722
LIPF-TMED6chr1090431722chr1669383554715DRB1-1457TIGFIAFSTNPSLAK722
LIPF-TMED6chr1090431722chr1669383554715DRB1-1463TIGFIAFSTNPSLAK722
LIPF-TMED6chr1090431722chr1669383554715DRB1-1467TIGFIAFSTNPSLAK722
LIPF-TMED6chr1090431722chr1669383554715DRB1-1467TTIGFIAFSTNPSLA621
LIPF-TMED6chr1090431722chr1669383554715DRB1-1477TIGFIAFSTNPSLAK722
LIPF-TMED6chr1090431722chr1669383554715DRB1-1489TIGFIAFSTNPSLAK722
LIPF-TMED6chr1090431722chr1669383554715DRB1-1489TTIGFIAFSTNPSLA621
LIPF-TMED6chr1090431722chr1669383554715DRB1-1489IGFIAFSTNPSLAKR823
LIPF-TMED6chr1090431722chr1669383554715DRB1-1494TIGFIAFSTNPSLAK722
LIPF-TMED6chr1090431722chr1669383554715DRB1-1498TIGFIAFSTNPSLAK722
LIPF-TMED6chr1090431722chr1669383554715DRB1-1502TIGFIAFSTNPSLAK722
LIPF-TMED6chr1090431722chr1669383554715DRB1-1502TTIGFIAFSTNPSLA621
LIPF-TMED6chr1090431722chr1669383554715DRB1-1502IGFIAFSTNPSLAKR823
LIPF-TMED6chr1090431722chr1669383554715DRB1-1502GTTIGFIAFSTNPSL520
LIPF-TMED6chr1090431722chr1669383554715DRB1-1508TIGFIAFSTNPSLAK722
LIPF-TMED6chr1090431722chr1669383554715DRB1-1508TTIGFIAFSTNPSLA621
LIPF-TMED6chr1090431722chr1669383554715DRB1-1508IGFIAFSTNPSLAKR823
LIPF-TMED6chr1090431722chr1669383554715DRB1-1508GTTIGFIAFSTNPSL520
LIPF-TMED6chr1090431722chr1669383554715DRB1-1511TIGFIAFSTNPSLAK722
LIPF-TMED6chr1090431722chr1669383554715DRB1-1511TTIGFIAFSTNPSLA621
LIPF-TMED6chr1090431722chr1669383554715DRB1-1511IGFIAFSTNPSLAKR823
LIPF-TMED6chr1090431722chr1669383554715DRB1-1511GTTIGFIAFSTNPSL520
LIPF-TMED6chr1090431722chr1669383554715DRB1-1514TIGFIAFSTNPSLAK722
LIPF-TMED6chr1090431722chr1669383554715DRB1-1514TTIGFIAFSTNPSLA621
LIPF-TMED6chr1090431722chr1669383554715DRB1-1514IGFIAFSTNPSLAKR823
LIPF-TMED6chr1090431722chr1669383554715DRB1-1514GTTIGFIAFSTNPSL520
LIPF-TMED6chr1090431722chr1669383554715DRB1-1515TIGFIAFSTNPSLAK722
LIPF-TMED6chr1090431722chr1669383554715DRB1-1515TTIGFIAFSTNPSLA621
LIPF-TMED6chr1090431722chr1669383554715DRB1-1515IGFIAFSTNPSLAKR823
LIPF-TMED6chr1090431722chr1669383554715DRB1-1515GTTIGFIAFSTNPSL520
LIPF-TMED6chr1090431722chr1669383554715DRB1-1519TIGFIAFSTNPSLAK722
LIPF-TMED6chr1090431722chr1669383554715DRB1-1519TTIGFIAFSTNPSLA621
LIPF-TMED6chr1090431722chr1669383554715DRB1-1519IGFIAFSTNPSLAKR823
LIPF-TMED6chr1090431722chr1669383554715DRB1-1519GTTIGFIAFSTNPSL520
LIPF-TMED6chr1090431722chr1669383554715DRB1-1521TIGFIAFSTNPSLAK722
LIPF-TMED6chr1090431722chr1669383554715DRB1-1525IGFIAFSTNPSLAKR823
LIPF-TMED6chr1090431722chr1669383554715DRB1-1525TIGFIAFSTNPSLAK722
LIPF-TMED6chr1090431722chr1669383554715DRB1-1526TIGFIAFSTNPSLAK722
LIPF-TMED6chr1090431722chr1669383554715DRB1-1526TTIGFIAFSTNPSLA621
LIPF-TMED6chr1090431722chr1669383554715DRB1-1526IGFIAFSTNPSLAKR823
LIPF-TMED6chr1090431722chr1669383554715DRB1-1526GTTIGFIAFSTNPSL520
LIPF-TMED6chr1090431722chr1669383554715DRB1-1527TIGFIAFSTNPSLAK722
LIPF-TMED6chr1090431722chr1669383554715DRB1-1527TTIGFIAFSTNPSLA621
LIPF-TMED6chr1090431722chr1669383554715DRB1-1527IGFIAFSTNPSLAKR823
LIPF-TMED6chr1090431722chr1669383554715DRB1-1527GTTIGFIAFSTNPSL520
LIPF-TMED6chr1090431722chr1669383554715DRB1-1529TIGFIAFSTNPSLAK722
LIPF-TMED6chr1090431722chr1669383554715DRB1-1529TTIGFIAFSTNPSLA621
LIPF-TMED6chr1090431722chr1669383554715DRB1-1529IGFIAFSTNPSLAKR823
LIPF-TMED6chr1090431722chr1669383554715DRB1-1530TIGFIAFSTNPSLAK722
LIPF-TMED6chr1090431722chr1669383554715DRB1-1530TTIGFIAFSTNPSLA621
LIPF-TMED6chr1090431722chr1669383554715DRB1-1530IGFIAFSTNPSLAKR823
LIPF-TMED6chr1090431722chr1669383554715DRB1-1530GTTIGFIAFSTNPSL520
LIPF-TMED6chr1090431722chr1669383554715DRB1-1531TIGFIAFSTNPSLAK722
LIPF-TMED6chr1090431722chr1669383554715DRB1-1531TTIGFIAFSTNPSLA621
LIPF-TMED6chr1090431722chr1669383554715DRB1-1531IGFIAFSTNPSLAKR823
LIPF-TMED6chr1090431722chr1669383554715DRB1-1531GTTIGFIAFSTNPSL520
LIPF-TMED6chr1090431722chr1669383554715DRB1-1534TIGFIAFSTNPSLAK722
LIPF-TMED6chr1090431722chr1669383554715DRB1-1534TTIGFIAFSTNPSLA621
LIPF-TMED6chr1090431722chr1669383554715DRB1-1534IGFIAFSTNPSLAKR823
LIPF-TMED6chr1090431722chr1669383554715DRB1-1534GTTIGFIAFSTNPSL520
LIPF-TMED6chr1090431722chr1669383554715DRB1-1538TIGFIAFSTNPSLAK722
LIPF-TMED6chr1090431722chr1669383554715DRB1-1538TTIGFIAFSTNPSLA621
LIPF-TMED6chr1090431722chr1669383554715DRB1-1538IGFIAFSTNPSLAKR823
LIPF-TMED6chr1090431722chr1669383554715DRB1-1538GTTIGFIAFSTNPSL520
LIPF-TMED6chr1090431722chr1669383554715DRB1-1539TIGFIAFSTNPSLAK722
LIPF-TMED6chr1090431722chr1669383554715DRB1-1539TTIGFIAFSTNPSLA621
LIPF-TMED6chr1090431722chr1669383554715DRB1-1539IGFIAFSTNPSLAKR823
LIPF-TMED6chr1090431722chr1669383554715DRB1-1539GTTIGFIAFSTNPSL520
LIPF-TMED6chr1090431722chr1669383554715DRB1-1544TIGFIAFSTNPSLAK722
LIPF-TMED6chr1090431722chr1669383554715DRB1-1544TTIGFIAFSTNPSLA621
LIPF-TMED6chr1090431722chr1669383554715DRB1-1544IGFIAFSTNPSLAKR823
LIPF-TMED6chr1090431722chr1669383554715DRB1-1544GTTIGFIAFSTNPSL520
LIPF-TMED6chr1090431722chr1669383554715DRB1-1547TIGFIAFSTNPSLAK722
LIPF-TMED6chr1090431722chr1669383554715DRB1-1547TTIGFIAFSTNPSLA621
LIPF-TMED6chr1090431722chr1669383554715DRB1-1547IGFIAFSTNPSLAKR823
LIPF-TMED6chr1090431722chr1669383554715DRB1-1547GTTIGFIAFSTNPSL520
LIPF-TMED6chr1090431722chr1669383554715DRB1-1601TIGFIAFSTNPSLAK722
LIPF-TMED6chr1090431722chr1669383554715DRB1-1601TTIGFIAFSTNPSLA621
LIPF-TMED6chr1090431722chr1669383554715DRB1-1602TIGFIAFSTNPSLAK722
LIPF-TMED6chr1090431722chr1669383554715DRB1-1602TTIGFIAFSTNPSLA621
LIPF-TMED6chr1090431722chr1669383554715DRB1-1602IGFIAFSTNPSLAKR823
LIPF-TMED6chr1090431722chr1669383554715DRB1-1602GTTIGFIAFSTNPSL520
LIPF-TMED6chr1090431722chr1669383554715DRB1-1603TIGFIAFSTNPSLAK722
LIPF-TMED6chr1090431722chr1669383554715DRB1-1603TTIGFIAFSTNPSLA621
LIPF-TMED6chr1090431722chr1669383554715DRB1-1604TIGFIAFSTNPSLAK722
LIPF-TMED6chr1090431722chr1669383554715DRB1-1604TTIGFIAFSTNPSLA621
LIPF-TMED6chr1090431722chr1669383554715DRB1-1604IGFIAFSTNPSLAKR823
LIPF-TMED6chr1090431722chr1669383554715DRB1-1604GTTIGFIAFSTNPSL520
LIPF-TMED6chr1090431722chr1669383554715DRB1-1605TIGFIAFSTNPSLAK722
LIPF-TMED6chr1090431722chr1669383554715DRB1-1605TTIGFIAFSTNPSLA621
LIPF-TMED6chr1090431722chr1669383554715DRB1-1605IGFIAFSTNPSLAKR823
LIPF-TMED6chr1090431722chr1669383554715DRB1-1605GTTIGFIAFSTNPSL520
LIPF-TMED6chr1090431722chr1669383554715DRB1-1607TIGFIAFSTNPSLAK722
LIPF-TMED6chr1090431722chr1669383554715DRB1-1607TTIGFIAFSTNPSLA621
LIPF-TMED6chr1090431722chr1669383554715DRB1-1607IGFIAFSTNPSLAKR823
LIPF-TMED6chr1090431722chr1669383554715DRB1-1607GTTIGFIAFSTNPSL520
LIPF-TMED6chr1090431722chr1669383554715DRB1-1608TIGFIAFSTNPSLAK722
LIPF-TMED6chr1090431722chr1669383554715DRB1-1608TTIGFIAFSTNPSLA621
LIPF-TMED6chr1090431722chr1669383554715DRB1-1609TIGFIAFSTNPSLAK722
LIPF-TMED6chr1090431722chr1669383554715DRB1-1609TTIGFIAFSTNPSLA621
LIPF-TMED6chr1090431722chr1669383554715DRB1-1609IGFIAFSTNPSLAKR823
LIPF-TMED6chr1090431722chr1669383554715DRB1-1609GTTIGFIAFSTNPSL520
LIPF-TMED6chr1090431722chr1669383554715DRB1-1610TIGFIAFSTNPSLAK722
LIPF-TMED6chr1090431722chr1669383554715DRB1-1610TTIGFIAFSTNPSLA621
LIPF-TMED6chr1090431722chr1669383554715DRB1-1610IGFIAFSTNPSLAKR823
LIPF-TMED6chr1090431722chr1669383554715DRB1-1610GTTIGFIAFSTNPSL520
LIPF-TMED6chr1090431722chr1669383554715DRB1-1611TIGFIAFSTNPSLAK722
LIPF-TMED6chr1090431722chr1669383554715DRB1-1611TTIGFIAFSTNPSLA621
LIPF-TMED6chr1090431722chr1669383554715DRB1-1611IGFIAFSTNPSLAKR823
LIPF-TMED6chr1090431722chr1669383554715DRB1-1611GTTIGFIAFSTNPSL520
LIPF-TMED6chr1090431722chr1669383554715DRB1-1612TIGFIAFSTNPSLAK722
LIPF-TMED6chr1090431722chr1669383554715DRB1-1612TTIGFIAFSTNPSLA621
LIPF-TMED6chr1090431722chr1669383554715DRB1-1612IGFIAFSTNPSLAKR823
LIPF-TMED6chr1090431722chr1669383554715DRB1-1612GTTIGFIAFSTNPSL520
LIPF-TMED6chr1090431722chr1669383554715DRB1-1614TIGFIAFSTNPSLAK722
LIPF-TMED6chr1090431722chr1669383554715DRB1-1614TTIGFIAFSTNPSLA621
LIPF-TMED6chr1090431722chr1669383554715DRB1-1614IGFIAFSTNPSLAKR823
LIPF-TMED6chr1090431722chr1669383554715DRB1-1614GTTIGFIAFSTNPSL520
LIPF-TMED6chr1090431722chr1669383554715DRB1-1615TIGFIAFSTNPSLAK722
LIPF-TMED6chr1090431722chr1669383554715DRB1-1616TIGFIAFSTNPSLAK722
LIPF-TMED6chr1090431722chr1669383554715DRB1-1616TTIGFIAFSTNPSLA621
LIPF-TMED6chr1090431722chr1669383554715DRB1-1616IGFIAFSTNPSLAKR823
LIPF-TMED6chr1090431722chr1669383554715DRB1-1616GTTIGFIAFSTNPSL520
LIPF-TMED6chr1090431722chr1669383554715DRB3-0205FIAFSTNPSLAKRIK1025
LIPF-TMED6chr1090431722chr1669383554715DRB3-0219FIAFSTNPSLAKRIK1025
LIPF-TMED6chr1090431722chr1669383554715DRB3-0222FIAFSTNPSLAKRIK1025
LIPF-TMED6chr1090431722chr1669383554715DRB5-0102TIGFIAFSTNPSLAK722
LIPF-TMED6chr1090431722chr1669383554715DRB5-0102TTIGFIAFSTNPSLA621
LIPF-TMED6chr1090431722chr1669383554715DRB5-0103TIGFIAFSTNPSLAK722
LIPF-TMED6chr1090431722chr1669383554715DRB5-0103TTIGFIAFSTNPSLA621
LIPF-TMED6chr1090431722chr1669383554715DRB5-0103IGFIAFSTNPSLAKR823
LIPF-TMED6chr1090431722chr1669383554715DRB5-0108NTIGFIAFSTNPSLAK722
LIPF-TMED6chr1090431722chr1669383554715DRB5-0108NTTIGFIAFSTNPSLA621
LIPF-TMED6chr1090431722chr1669383554715DRB5-0111TIGFIAFSTNPSLAK722
LIPF-TMED6chr1090431722chr1669383554715DRB5-0112TIGFIAFSTNPSLAK722
LIPF-TMED6chr1090431722chr1669383554715DRB5-0203TIGFIAFSTNPSLAK722
LIPF-TMED6chr1090431722chr1669383554715DRB5-0203TTIGFIAFSTNPSLA621
LIPF-TMED6chr1090431722chr1669383554715DRB5-0203IGFIAFSTNPSLAKR823
LIPF-TMED6chr1090431722chr1669383554715DRB5-0203GTTIGFIAFSTNPSL520

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Fusion breakpoint peptide structures of LIPF-TMED6

check button3D structures of the fusion breakpoint peptide of 14AA sequence that have potential fusion neoantigens
* The minimum length of the amino acid sequence in RoseTTAFold is 14AA. Here, we predicted the 14AA fusion protein breakpoint sequence not the fusion neoantigen peptide, which is shorter than 14 AA.
File nameBPseqHgeneTgeneHchrHbpTchrTbpAAlen
9694TTIGFIAFSTNPSLLIPFTMED6chr1090431722chr1669383554715

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Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D of LIPF-TMED6

check buttonVirtual screening between 25 HLAs (from PDB) and FusionNeoAntigens
* We used Glide to predict the interaction between HLAs and neoantigens.
HLA allelePDB IDFile nameBPseqDocking scoreGlide score
HLA-B14:023BVN9694TTIGFIAFSTNPSL-7.15543-7.26883
HLA-B14:023BVN9694TTIGFIAFSTNPSL-4.77435-5.80965
HLA-B52:013W399694TTIGFIAFSTNPSL-6.80875-6.92215
HLA-B52:013W399694TTIGFIAFSTNPSL-4.20386-5.23916
HLA-A11:014UQ29694TTIGFIAFSTNPSL-7.5194-8.5547
HLA-A11:014UQ29694TTIGFIAFSTNPSL-6.9601-7.0735
HLA-A24:025HGA9694TTIGFIAFSTNPSL-7.52403-7.63743
HLA-A24:025HGA9694TTIGFIAFSTNPSL-5.82433-6.85963
HLA-B27:056PYJ9694TTIGFIAFSTNPSL-3.28285-4.31815
HLA-B44:053DX89694TTIGFIAFSTNPSL-5.91172-6.94702
HLA-B44:053DX89694TTIGFIAFSTNPSL-4.24346-4.35686

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Vaccine Design for the FusionNeoAntigens of LIPF-TMED6

check button mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-Is.
Fusion geneHchrHbpTchrTbpStart in +/-13AAEnd in +/-13AAFusionNeoAntigen peptide sequenceFusionNeoAntigen RNA sequence
LIPF-TMED6chr1090431722chr16693835541020FIAFSTNPSLCTCTTCAAGGTTCAGCGGACAGTGGGGATG
LIPF-TMED6chr1090431722chr16693835541120IAFSTNPSLTTCAAGGTTCAGCGGACAGTGGGGATG
LIPF-TMED6chr1090431722chr16693835541220AFSTNPSLAAGGTTCAGCGGACAGTGGGGATG
LIPF-TMED6chr1090431722chr16693835541223AFSTNPSLAKRAAGGTTCAGCGGACAGTGGGGATGTCACATGAC

check button mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-IIs.
Fusion geneHchrHbpTchrTbpStart in +/-13AAEnd in +/-13AAFusionNeoAntigen peptideFusionNEoAntigen RNA sequence
LIPF-TMED6chr1090431722chr16693835541025FIAFSTNPSLAKRIKCTCTTCAAGGTTCAGCGGACAGTGGGGATGTCACATGACCGGCAT
LIPF-TMED6chr1090431722chr1669383554520GTTIGFIAFSTNPSLTTTGTTCCTCAATCCCTCTTCAAGGTTCAGCGGACAGTGGGGATG
LIPF-TMED6chr1090431722chr1669383554621TTIGFIAFSTNPSLAGTTCCTCAATCCCTCTTCAAGGTTCAGCGGACAGTGGGGATGTCA
LIPF-TMED6chr1090431722chr1669383554722TIGFIAFSTNPSLAKCCTCAATCCCTCTTCAAGGTTCAGCGGACAGTGGGGATGTCACAT
LIPF-TMED6chr1090431722chr1669383554823IGFIAFSTNPSLAKRCAATCCCTCTTCAAGGTTCAGCGGACAGTGGGGATGTCACATGAC

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Information of the samples that have these potential fusion neoantigens of LIPF-TMED6

check button These samples were reported as having these fusion breakpoints. For individual breakpoints, we checked the open reading frames considering multiple gene isoforms and chose the in-frame fusion genes only. Then, we made fusion protein sequences and predicted the fusion neoantigens. These fusion-positive samples may have these potential fusion neoantigens.
Cancer typeFusion geneHchrHbpHenstTchrTbpTenstSample
Non-CancerLIPF-TMED6chr1090431722ENST00000238983chr1669383554ENST00000288025217N

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Potential target of CAR-T therapy development for LIPF-TMED6

check button Predicted 3D structure. We used RoseTTAFold.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, to provide the retention of the transmembrane domain, we only show the protein feature retention information of those transmembrane features


* Minus value of BPloci means that the break point is located before the CDS.
- In-frame and retained 'Transmembrane'.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneTMED6chr10:90431722chr16:69383554ENST0000028802504201_2230241.0TransmembraneHelical

check button Subcellular localization prediction of the transmembrane domain retained fusion proteins
* We used DeepLoc 1.0. The order of the X-axis of the barplot is as follows: Entry_ID, Localization, Type, Nucleus, Cytoplasm, Extracellular, Mitochondrion, Cell_membrane, Endoplasmic_reticulum, Plastid, Golgi.apparatus, Lysosome.Vacuole, Peroxisome. Y-axis is the output score of DeepLoc. Clicking the image will open a new tab with a large image.
HgeneHchrHbpHenstTgeneTchrTbpTenstDeepLoc result

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Related Drugs to LIPF-TMED6

check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to LIPF-TMED6

check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource