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Fusion Protein:MBOAT1-DCDC2

Fusion Gene and Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: MBOAT1-DCDC2
	FusionPDB ID: 52036
	FusionGDB2.0 ID: 52036
		Hgene	Tgene
	Gene symbol	MBOAT1	DCDC2
	Gene ID	154141	51473
	Gene name	membrane bound O-acyltransferase domain containing 1	doublecortin domain containing 2
	Synonyms	LPEAT1\|LPLAT\|LPLAT 1\|LPSAT\|OACT1\|dJ434O11.1	DCDC2A\|DFNB66\|NPHP19\|NSC\|RU2\|RU2S
	Cytomap	6p22.3	6p22.3
	Type of gene	protein-coding	protein-coding
	Description	lysophospholipid acyltransferase 11-acylglycerophosphoserine O-acyltransferaseO-acyltransferase (membrane bound) domain containing 1O-acyltransferase domain-containing protein 1lyso-PS acyltransferaselysophosphatidylethanolamine acyltransferase 1lys	doublecortin domain-containing protein 2
	Modification date	20200313	20200313
	UniProtAcc	Q6ZNC8 Main function of 5'-partner protein: FUNCTION: Acyltransferase which catalyzes the transfert of an acyl group from an acyl-CoA towards a lysophospholipid producing a phospholipid and participates in the reacylation step of the phospholipid remodeling pathway also known as the Lands cycle (PubMed:18772128). Acts on lysophosphatidylserine (1-acyl-2-hydroxy-sn-glycero-3-phospho-L-serine or LPS) and lysophosphatidylethanolamine (1-acyl-sn-glycero-3-phosphoethanolamine or LPE), and to a lesser extend lysophosphatidylcholine (PubMed:18772128). Prefers oleoyl-CoA as the acyl donor and 1-oleoyl-LPE as acceptor (PubMed:18772128). May play a role in neurite outgrowth during neuronal differentiation (By similarity). {ECO:0000250\|UniProtKB:Q8BH98, ECO:0000269\|PubMed:18772128}.	Q9UHG0 Main function of 5'-partner protein: FUNCTION: Protein that plays a role in the inhibition of canonical Wnt signaling pathway (PubMed:25557784). May be involved in neuronal migration during development of the cerebral neocortex (By similarity). Involved in the control of ciliogenesis and ciliary length (PubMed:25601850, PubMed:27319779). {ECO:0000250\|UniProtKB:D3ZR10, ECO:0000269\|PubMed:25557784, ECO:0000269\|PubMed:25601850, ECO:0000269\|PubMed:27319779}.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000324607, ENST00000536798, ENST00000541730,	ENST00000378450, ENST00000378454,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	14 X 16 X 9=2016	14 X 8 X 11=1232
	# samples	21	16
	** MAII score	log2(21/2016*10)=-3.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(16/1232*10)=-2.94485844580754 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Fusion gene context	PubMed: MBOAT1 [Title/Abstract] AND DCDC2 [Title/Abstract] AND fusion [Title/Abstract]
Fusion neoantigen context	PubMed: MBOAT1 [Title/Abstract] AND DCDC2 [Title/Abstract] AND neoantigen [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	MBOAT1(20126748)-DCDC2(24302272), # samples:2
Anticipated loss of major functional domain due to fusion event.	MBOAT1-DCDC2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. MBOAT1-DCDC2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. MBOAT1-DCDC2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. MBOAT1-DCDC2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr6:20126748/chr6:24302272)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Retention analysis results of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features, are available here.

Fusion gene breakpoints across MBOAT1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across DCDC2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Amino Acid Sequences

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000541730	MBOAT1	chr6	20126748	-	ENST00000378454	DCDC2	chr6	24302272	-	4920	863	596	1945	449
ENST00000324607	MBOAT1	chr6	20126748	-	ENST00000378454	DCDC2	chr6	24302272	-	4936	879	6	1961	651
ENST00000536798	MBOAT1	chr6	20126748	-	ENST00000378454	DCDC2	chr6	24302272	-	4976	919	16	2001	661
ENST00000541730	MBOAT1	chr6	20126747	-	ENST00000378454	DCDC2	chr6	24302272	-	4920	863	596	1945	449
ENST00000324607	MBOAT1	chr6	20126747	-	ENST00000378454	DCDC2	chr6	24302272	-	4936	879	6	1961	651
ENST00000536798	MBOAT1	chr6	20126747	-	ENST00000378454	DCDC2	chr6	24302272	-	4976	919	16	2001	661

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000541730	ENST00000378454	MBOAT1	chr6	20126748	-	DCDC2	chr6	24302272	-	8.90E-05	0.99991095
ENST00000324607	ENST00000378454	MBOAT1	chr6	20126748	-	DCDC2	chr6	24302272	-	0.000263297	0.9997367
ENST00000536798	ENST00000378454	MBOAT1	chr6	20126748	-	DCDC2	chr6	24302272	-	0.00027083	0.9997292
ENST00000541730	ENST00000378454	MBOAT1	chr6	20126747	-	DCDC2	chr6	24302272	-	8.90E-05	0.99991095
ENST00000324607	ENST00000378454	MBOAT1	chr6	20126747	-	DCDC2	chr6	24302272	-	0.000263297	0.9997367
ENST00000536798	ENST00000378454	MBOAT1	chr6	20126747	-	DCDC2	chr6	24302272	-	0.00027083	0.9997292

Predicted full-length fusion amino acid sequences. For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among all the predicted ones.

Get the fusion protein sequences from here.

Fusion protein sequence information is available in the fasta format.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

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Fusion Protein Breakpoint Sequences for MBOAT1-DCDC2

+/-13 AA sequence from the breakpoints of the fusion protein sequences.

Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	Length(fusion protein)	BP in fusion protein	Peptide
MBOAT1	chr6	20126747	DCDC2	chr6	24302272	863	89	RKGFHSLPEPSPTVKPVIHSRINVSA
MBOAT1	chr6	20126747	DCDC2	chr6	24302272	879	291	RKGFHSLPEPSPTVKPVIHSRINVSA
MBOAT1	chr6	20126747	DCDC2	chr6	24302272	919	301	RKGFHSLPEPSPTVKPVIHSRINVSA
MBOAT1	chr6	20126748	DCDC2	chr6	24302272	863	89	RKGFHSLPEPSPTVKPVIHSRINVSA
MBOAT1	chr6	20126748	DCDC2	chr6	24302272	879	291	RKGFHSLPEPSPTVKPVIHSRINVSA
MBOAT1	chr6	20126748	DCDC2	chr6	24302272	919	301	RKGFHSLPEPSPTVKPVIHSRINVSA

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Potential FusionNeoAntigen Information of MBOAT1-DCDC2 in HLA I

Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.

MBOAT1-DCDC2_20126747_24302272.msa

Potential FusionNeoAntigen Information
* We used NetMHCpan v4.1 (%rank<0.5) and deepHLApan v1.1 (immunogenic score>0.5)

Fusion gene	Hchr	Hbp	Tgene	Tchr	Tbp	HLA I	FusionNeoAntigen peptide	Binding score	Immunogenic score	Neoantigen start (at BP 13)	Neoantigen end (at BP 13)
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	HLA-B51:01	LPEPSPTV	0.9994	0.9508	6	14
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	HLA-B51:02	LPEPSPTV	0.9987	0.9069	6	14
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	HLA-B35:02	LPEPSPTV	0.9814	0.9882	6	14
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	HLA-B35:04	LPEPSPTV	0.9814	0.9882	6	14
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	HLA-A02:22	SLPEPSPTV	0.9968	0.8721	5	14
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	HLA-A02:27	SLPEPSPTV	0.9954	0.8792	5	14
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	HLA-A02:13	SLPEPSPTV	0.9953	0.9084	5	14
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	HLA-A30:08	TVKPVIHSR	0.9939	0.7081	12	21
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	HLA-A02:67	SLPEPSPTV	0.9934	0.8547	5	14
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	HLA-A02:30	SLPEPSPTV	0.9934	0.8547	5	14
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	HLA-A02:24	SLPEPSPTV	0.9934	0.8547	5	14
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	HLA-A02:60	SLPEPSPTV	0.9933	0.8668	5	14
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	HLA-A74:09	TVKPVIHSR	0.9933	0.5374	12	21
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	HLA-A74:11	TVKPVIHSR	0.9933	0.5374	12	21
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	HLA-A74:03	TVKPVIHSR	0.9933	0.5374	12	21
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	HLA-A02:11	SLPEPSPTV	0.9927	0.8631	5	14
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	HLA-A02:21	SLPEPSPTV	0.9927	0.9034	5	14
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	HLA-A02:38	SLPEPSPTV	0.992	0.9028	5	14
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	HLA-A02:16	SLPEPSPTV	0.9916	0.8082	5	14
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	HLA-A02:29	SLPEPSPTV	0.9855	0.8553	5	14
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	HLA-A02:35	SLPEPSPTV	0.9839	0.87	5	14
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	HLA-A02:19	SLPEPSPTV	0.9828	0.8288	5	14
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	HLA-A02:04	SLPEPSPTV	0.9815	0.939	5	14
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	HLA-A02:20	SLPEPSPTV	0.9785	0.8613	5	14
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	HLA-A31:02	TVKPVIHSR	0.9718	0.5252	12	21
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	HLA-A02:17	SLPEPSPTV	0.9697	0.8868	5	14
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	HLA-B35:04	EPSPTVKPV	0.8802	0.7991	8	17
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	HLA-B35:02	EPSPTVKPV	0.8802	0.7991	8	17
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	HLA-B35:03	EPSPTVKPV	0.8145	0.5893	8	17
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	HLA-B08:09	EPSPTVKPV	0.7918	0.5786	8	17
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	HLA-B52:01	SLPEPSPTV	0.3544	0.995	5	14
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	HLA-B13:02	SLPEPSPTV	0.2174	0.8812	5	14
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	HLA-A02:38	HSLPEPSPTV	0.9642	0.9266	4	14
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	HLA-A02:21	HSLPEPSPTV	0.9466	0.9174	4	14
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	HLA-A02:35	HSLPEPSPTV	0.9405	0.8949	4	14
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	HLA-A02:22	HSLPEPSPTV	0.9315	0.8981	4	14
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	HLA-A02:60	HSLPEPSPTV	0.9203	0.8966	4	14
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	HLA-A02:29	HSLPEPSPTV	0.9191	0.8824	4	14
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	HLA-A02:20	HSLPEPSPTV	0.9188	0.8882	4	14
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	HLA-A02:24	HSLPEPSPTV	0.9147	0.8822	4	14
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	HLA-A02:67	HSLPEPSPTV	0.9147	0.8822	4	14
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	HLA-A02:30	HSLPEPSPTV	0.9147	0.8822	4	14
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	HLA-A02:11	HSLPEPSPTV	0.9062	0.8882	4	14
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	HLA-A02:17	HSLPEPSPTV	0.9054	0.9313	4	14
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	HLA-A02:13	HSLPEPSPTV	0.8757	0.9273	4	14
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	HLA-A02:27	HSLPEPSPTV	0.8574	0.8947	4	14
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	HLA-A02:16	HSLPEPSPTV	0.8542	0.8392	4	14
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	HLA-A02:19	HSLPEPSPTV	0.616	0.8266	4	14
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	HLA-B39:01	FHSLPEPSPTV	0.9999	0.9892	3	14
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	HLA-B39:06	FHSLPEPSPTV	0.9999	0.9805	3	14
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	HLA-B38:01	FHSLPEPSPTV	0.9998	0.9957	3	14
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	HLA-B15:10	FHSLPEPSPTV	0.9991	0.9062	3	14
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	HLA-B51:02	LPEPSPTVKPV	0.9886	0.5024	6	17
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	HLA-A02:35	FHSLPEPSPTV	0.983	0.8244	3	14
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	HLA-A02:17	FHSLPEPSPTV	0.9754	0.8739	3	14
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	HLA-A02:04	FHSLPEPSPTV	0.9749	0.9319	3	14
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	HLA-A02:21	FHSLPEPSPTV	0.9641	0.8682	3	14
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	HLA-A74:03	SPTVKPVIHSR	0.9618	0.5137	10	21
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	HLA-A74:11	SPTVKPVIHSR	0.9618	0.5137	10	21
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	HLA-A74:09	SPTVKPVIHSR	0.9618	0.5137	10	21
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	HLA-A31:02	SPTVKPVIHSR	0.958	0.5193	10	21
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	HLA-A02:20	FHSLPEPSPTV	0.9573	0.8141	3	14
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	HLA-A02:29	FHSLPEPSPTV	0.9516	0.807	3	14
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	HLA-A02:60	FHSLPEPSPTV	0.9422	0.7804	3	14
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	HLA-A02:16	FHSLPEPSPTV	0.9405	0.6986	3	14
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	HLA-A02:13	FHSLPEPSPTV	0.9356	0.8986	3	14
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	HLA-A02:11	FHSLPEPSPTV	0.9351	0.8304	3	14
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	HLA-A02:38	FHSLPEPSPTV	0.934	0.8999	3	14
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	HLA-A02:30	FHSLPEPSPTV	0.9338	0.8045	3	14
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	HLA-A02:24	FHSLPEPSPTV	0.9338	0.8045	3	14
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	HLA-A02:67	FHSLPEPSPTV	0.9338	0.8045	3	14
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	HLA-A02:27	FHSLPEPSPTV	0.9204	0.8547	3	14
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	HLA-A02:22	FHSLPEPSPTV	0.915	0.8101	3	14
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	HLA-A02:19	FHSLPEPSPTV	0.8371	0.726	3	14
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	HLA-B78:01	LPEPSPTV	0.9994	0.9306	6	14
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	HLA-B51:08	LPEPSPTV	0.9969	0.8722	6	14
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	HLA-B54:01	LPEPSPTV	0.9945	0.8742	6	14
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	HLA-B35:12	LPEPSPTV	0.9814	0.9882	6	14
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	HLA-A02:07	LPEPSPTV	0.8074	0.853	6	14
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	HLA-B39:10	LPEPSPTV	0.6044	0.9936	6	14
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	HLA-A02:02	SLPEPSPTV	0.9968	0.7673	5	14
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	HLA-A02:05	SLPEPSPTV	0.9959	0.8479	5	14
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	HLA-A02:07	SLPEPSPTV	0.9937	0.8798	5	14
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	HLA-A02:01	SLPEPSPTV	0.9934	0.8547	5	14
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	HLA-C05:09	SLPEPSPTV	0.9931	0.9923	5	14
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	HLA-C04:10	SLPEPSPTV	0.9456	0.9792	5	14
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	HLA-B51:07	EPSPTVKPV	0.9373	0.7877	8	17
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	HLA-C04:07	SLPEPSPTV	0.9371	0.9763	5	14
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	HLA-C04:06	SLPEPSPTV	0.8977	0.9896	5	14
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	HLA-B35:12	EPSPTVKPV	0.8802	0.7991	8	17
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	HLA-C08:15	SLPEPSPTV	0.8064	0.9926	5	14
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	HLA-C04:14	SLPEPSPTV	0.753	0.9797	5	14
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	HLA-C01:17	SLPEPSPTV	0.7319	0.9899	5	14
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	HLA-C01:30	SLPEPSPTV	0.7306	0.9915	5	14
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	HLA-C02:06	SLPEPSPTV	0.5984	0.9912	5	14
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	HLA-C08:04	SLPEPSPTV	0.4669	0.9896	5	14
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	HLA-C08:13	SLPEPSPTV	0.4669	0.9896	5	14
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	HLA-B51:07	SLPEPSPTV	0.3409	0.9937	5	14
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	HLA-B39:10	EPSPTVKPV	0.3108	0.8945	8	17
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	HLA-C08:03	SLPEPSPTV	0.2794	0.9957	5	14
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	HLA-C07:19	SLPEPSPTV	0.1355	0.9613	5	14
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	HLA-C07:13	SLPEPSPTV	0.0947	0.9912	5	14
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	HLA-C07:29	SLPEPSPTV	0.0888	0.9896	5	14
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	HLA-A02:05	HSLPEPSPTV	0.9593	0.8663	4	14
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	HLA-A02:02	HSLPEPSPTV	0.933	0.8039	4	14
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	HLA-C01:17	HSLPEPSPTV	0.9217	0.992	4	14
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	HLA-A02:07	HSLPEPSPTV	0.9166	0.9086	4	14
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	HLA-A02:01	HSLPEPSPTV	0.9147	0.8822	4	14
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	HLA-C01:30	HSLPEPSPTV	0.7861	0.9916	4	14
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	HLA-A02:07	SLPEPSPTVK	0.2928	0.8693	5	15
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	HLA-B39:09	FHSLPEPSPTV	0.9999	0.9046	3	14
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	HLA-B39:05	FHSLPEPSPTV	0.9998	0.987	3	14
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	HLA-C01:17	FHSLPEPSPTV	0.998	0.9895	3	14
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	HLA-C01:30	FHSLPEPSPTV	0.9835	0.9932	3	14
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	HLA-A02:05	FHSLPEPSPTV	0.9618	0.788	3	14
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	HLA-A02:01	FHSLPEPSPTV	0.9338	0.8045	3	14
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	HLA-A02:07	FHSLPEPSPTV	0.9324	0.8422	3	14
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	HLA-A02:02	FHSLPEPSPTV	0.9217	0.698	3	14
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	HLA-B78:02	LPEPSPTV	0.9995	0.9886	6	14
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	HLA-B51:13	LPEPSPTV	0.9994	0.8752	6	14
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	HLA-B51:14	LPEPSPTV	0.9994	0.8838	6	14
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	HLA-B51:21	LPEPSPTV	0.9989	0.965	6	14
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	HLA-B51:06	LPEPSPTV	0.9984	0.9348	6	14
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	HLA-B51:09	LPEPSPTV	0.9983	0.9283	6	14
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	HLA-B35:22	LPEPSPTV	0.9976	0.7024	6	14
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	HLA-B56:05	LPEPSPTV	0.9972	0.9052	6	14
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	HLA-B51:29	LPEPSPTV	0.9965	0.8503	6	14
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	HLA-B51:05	LPEPSPTV	0.9934	0.7464	6	14
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	HLA-B35:09	LPEPSPTV	0.9814	0.9882	6	14
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	HLA-B59:01	LPEPSPTV	0.974	0.8585	6	14
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	HLA-B67:01	LPEPSPTV	0.7431	0.9919	6	14
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	HLA-A02:03	SLPEPSPTV	0.9969	0.9168	5	14
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	HLA-A30:01	TVKPVIHSR	0.9937	0.7969	12	21
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	HLA-A74:01	TVKPVIHSR	0.9933	0.5374	12	21
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	HLA-C05:01	SLPEPSPTV	0.9931	0.9923	5	14
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	HLA-A02:14	SLPEPSPTV	0.993	0.8847	5	14
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	HLA-A02:06	SLPEPSPTV	0.9927	0.9034	5	14
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	HLA-C04:03	SLPEPSPTV	0.9919	0.9803	5	14
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	HLA-C18:01	SLPEPSPTV	0.9725	0.9805	5	14
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	HLA-C06:06	SLPEPSPTV	0.9534	0.9954	5	14
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	HLA-C04:01	SLPEPSPTV	0.9371	0.9763	5	14
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	HLA-B35:09	EPSPTVKPV	0.8802	0.7991	8	17
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	HLA-A68:02	SLPEPSPTV	0.8787	0.9631	5	14
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	HLA-C01:03	SLPEPSPTV	0.8654	0.9835	5	14
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	HLA-A69:01	SLPEPSPTV	0.8428	0.9559	5	14
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	HLA-B15:73	SLPEPSPTV	0.8086	0.9931	5	14
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	HLA-C08:02	SLPEPSPTV	0.8064	0.9926	5	14
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	HLA-C04:04	SLPEPSPTV	0.7739	0.9848	5	14
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	HLA-B15:30	SLPEPSPTV	0.7398	0.9754	5	14
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	HLA-C01:02	SLPEPSPTV	0.7272	0.9891	5	14
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	HLA-C03:06	SLPEPSPTV	0.6555	0.9973	5	14
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	HLA-B67:01	EPSPTVKPV	0.5195	0.773	8	17
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	HLA-C17:01	SLPEPSPTV	0.5135	0.9862	5	14
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	HLA-C06:08	SLPEPSPTV	0.4487	0.9954	5	14
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	HLA-C08:01	SLPEPSPTV	0.2794	0.9957	5	14
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	HLA-B07:13	SLPEPSPTV	0.1063	0.8934	5	14
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	HLA-C07:04	SLPEPSPTV	0.0737	0.9922	5	14
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	HLA-B40:21	SLPEPSPTV	0.0715	0.7936	5	14
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	HLA-B48:05	SLPEPSPTV	0.033	0.5561	5	14
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	HLA-C01:03	HSLPEPSPTV	0.9852	0.985	4	14
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	HLA-A69:01	HSLPEPSPTV	0.9548	0.9719	4	14
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	HLA-A68:02	HSLPEPSPTV	0.9501	0.9778	4	14
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	HLA-A02:03	HSLPEPSPTV	0.9498	0.9306	4	14
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	HLA-A02:14	HSLPEPSPTV	0.948	0.9034	4	14
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	HLA-A02:06	HSLPEPSPTV	0.9466	0.9174	4	14
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	HLA-C01:02	HSLPEPSPTV	0.9442	0.9915	4	14
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	HLA-B38:05	FHSLPEPSPTV	0.9998	0.9957	3	14
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	HLA-B15:09	FHSLPEPSPTV	0.9994	0.9597	3	14
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	HLA-C01:03	FHSLPEPSPTV	0.9986	0.9793	3	14
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	HLA-C01:02	FHSLPEPSPTV	0.9971	0.9886	3	14
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	HLA-B39:11	FHSLPEPSPTV	0.9955	0.9659	3	14
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	HLA-B59:01	LPEPSPTVKPV	0.9847	0.6732	6	17
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	HLA-A02:14	FHSLPEPSPTV	0.9642	0.8482	3	14
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	HLA-A02:06	FHSLPEPSPTV	0.9641	0.8682	3	14
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	HLA-A74:01	SPTVKPVIHSR	0.9618	0.5137	10	21
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	HLA-A02:03	FHSLPEPSPTV	0.9298	0.8786	3	14

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Potential FusionNeoAntigen Information of MBOAT1-DCDC2 in HLA II

MBOAT1-DCDC2_20126747_24302272.msa

Potential FusionNeoAntigen Information
* We used NetMHCIIpan v4.1 (%rank<0.5).

Fusion gene	Hchr	Hbp	Tgene	Tchr	Tbp	HLA II	FusionNeoAntigen peptide	Neoantigen start (at BP 13)	Neoantigen end (at BP 13)
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	DRB1-1220	SPTVKPVIHSRINVS	10	25
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	DRB1-1401	SPTVKPVIHSRINVS	10	25
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	DRB1-1401	PSPTVKPVIHSRINV	9	24
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	DRB1-1401	EPSPTVKPVIHSRIN	8	23
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	DRB1-1404	SPTVKPVIHSRINVS	10	25
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	DRB1-1404	PSPTVKPVIHSRINV	9	24
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	DRB1-1404	EPSPTVKPVIHSRIN	8	23
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	DRB1-1411	SPTVKPVIHSRINVS	10	25
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	DRB1-1411	PSPTVKPVIHSRINV	9	24
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	DRB1-1418	SPTVKPVIHSRINVS	10	25
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	DRB1-1418	PSPTVKPVIHSRINV	9	24
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	DRB1-1426	SPTVKPVIHSRINVS	10	25
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	DRB1-1426	PSPTVKPVIHSRINV	9	24
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	DRB1-1426	EPSPTVKPVIHSRIN	8	23
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	DRB1-1428	SPTVKPVIHSRINVS	10	25
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	DRB1-1428	PSPTVKPVIHSRINV	9	24
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	DRB1-1428	EPSPTVKPVIHSRIN	8	23
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	DRB1-1431	SPTVKPVIHSRINVS	10	25
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	DRB1-1431	PSPTVKPVIHSRINV	9	24
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	DRB1-1432	SPTVKPVIHSRINVS	10	25
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	DRB1-1432	PSPTVKPVIHSRINV	9	24
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	DRB1-1435	SPTVKPVIHSRINVS	10	25
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	DRB1-1435	PSPTVKPVIHSRINV	9	24
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	DRB1-1438	SPTVKPVIHSRINVS	10	25
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	DRB1-1438	PSPTVKPVIHSRINV	9	24
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	DRB1-1439	SPTVKPVIHSRINVS	10	25
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	DRB1-1439	PSPTVKPVIHSRINV	9	24
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	DRB1-1439	EPSPTVKPVIHSRIN	8	23
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	DRB1-1443	SPTVKPVIHSRINVS	10	25
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	DRB1-1450	SPTVKPVIHSRINVS	10	25
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	DRB1-1450	PSPTVKPVIHSRINV	9	24
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	DRB1-1450	EPSPTVKPVIHSRIN	8	23
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	DRB1-1454	SPTVKPVIHSRINVS	10	25
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	DRB1-1454	PSPTVKPVIHSRINV	9	24
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	DRB1-1454	EPSPTVKPVIHSRIN	8	23
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	DRB1-1455	SPTVKPVIHSRINVS	10	25
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	DRB1-1455	PSPTVKPVIHSRINV	9	24
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	DRB1-1458	SPTVKPVIHSRINVS	10	25
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	DRB1-1458	PSPTVKPVIHSRINV	9	24
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	DRB1-1458	EPSPTVKPVIHSRIN	8	23
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	DRB1-1460	SPTVKPVIHSRINVS	10	25
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	DRB1-1460	PSPTVKPVIHSRINV	9	24
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	DRB1-1460	EPSPTVKPVIHSRIN	8	23
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	DRB1-1461	SPTVKPVIHSRINVS	10	25
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	DRB1-1461	PSPTVKPVIHSRINV	9	24
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	DRB1-1461	EPSPTVKPVIHSRIN	8	23
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	DRB1-1462	SPTVKPVIHSRINVS	10	25
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	DRB1-1462	PSPTVKPVIHSRINV	9	24
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	DRB1-1470	SPTVKPVIHSRINVS	10	25
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	DRB1-1470	PSPTVKPVIHSRINV	9	24
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	DRB1-1470	EPSPTVKPVIHSRIN	8	23
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	DRB1-1471	SPTVKPVIHSRINVS	10	25
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	DRB1-1471	PSPTVKPVIHSRINV	9	24
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	DRB1-1471	EPSPTVKPVIHSRIN	8	23
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	DRB1-1475	SPTVKPVIHSRINVS	10	25
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	DRB1-1475	PSPTVKPVIHSRINV	9	24
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	DRB1-1475	EPSPTVKPVIHSRIN	8	23
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	DRB1-1482	SPTVKPVIHSRINVS	10	25
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	DRB1-1482	PSPTVKPVIHSRINV	9	24
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	DRB1-1486	SPTVKPVIHSRINVS	10	25
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	DRB1-1486	PSPTVKPVIHSRINV	9	24
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	DRB1-1486	EPSPTVKPVIHSRIN	8	23
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	DRB1-1487	SPTVKPVIHSRINVS	10	25
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	DRB1-1487	PSPTVKPVIHSRINV	9	24
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	DRB1-1487	EPSPTVKPVIHSRIN	8	23
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	DRB1-1488	SPTVKPVIHSRINVS	10	25
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	DRB1-1488	PSPTVKPVIHSRINV	9	24
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	DRB1-1488	EPSPTVKPVIHSRIN	8	23
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	DRB1-1490	SPTVKPVIHSRINVS	10	25
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	DRB1-1490	PSPTVKPVIHSRINV	9	24
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	DRB1-1490	EPSPTVKPVIHSRIN	8	23
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	DRB1-1497	SPTVKPVIHSRINVS	10	25
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	DRB1-1497	PSPTVKPVIHSRINV	9	24
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	DRB1-1497	EPSPTVKPVIHSRIN	8	23
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	DRB1-1499	SPTVKPVIHSRINVS	10	25
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	DRB1-1499	PSPTVKPVIHSRINV	9	24
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	879	DRB1-1499	EPSPTVKPVIHSRIN	8	23

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Fusion breakpoint peptide structures of MBOAT1-DCDC2

3D structures of the fusion breakpoint peptide of 14AA sequence that have potential fusion neoantigens
* The minimum length of the amino acid sequence in RoseTTAFold is 14AA. Here, we predicted the 14AA fusion protein breakpoint sequence not the fusion neoantigen peptide, which is shorter than 14 AA.

File name	BPseq	Hgene	Tgene	Hchr	Hbp	Tchr	Tbp	AAlen
5379	LPEPSPTVKPVIHS	MBOAT1	DCDC2	chr6	20126747	chr6	24302272	879

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Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D of MBOAT1-DCDC2

Virtual screening between 25 HLAs (from PDB) and FusionNeoAntigens
* We used Glide to predict the interaction between HLAs and neoantigens.

HLA allele	PDB ID	File name	BPseq	Docking score	Glide score
HLA-B14:02	3BVN	5379	LPEPSPTVKPVIHS	-7.9962	-8.1096
HLA-B14:02	3BVN	5379	LPEPSPTVKPVIHS	-5.70842	-6.74372
HLA-B52:01	3W39	5379	LPEPSPTVKPVIHS	-6.83737	-6.95077
HLA-B52:01	3W39	5379	LPEPSPTVKPVIHS	-4.4836	-5.5189
HLA-A11:01	4UQ2	5379	LPEPSPTVKPVIHS	-10.0067	-10.1201
HLA-A11:01	4UQ2	5379	LPEPSPTVKPVIHS	-9.03915	-10.0745
HLA-A24:02	5HGA	5379	LPEPSPTVKPVIHS	-6.56204	-6.67544
HLA-A24:02	5HGA	5379	LPEPSPTVKPVIHS	-5.42271	-6.45801
HLA-B44:05	3DX8	5379	LPEPSPTVKPVIHS	-7.85648	-8.89178
HLA-B44:05	3DX8	5379	LPEPSPTVKPVIHS	-5.3978	-5.5112
HLA-A02:01	6TDR	5379	LPEPSPTVKPVIHS	-3.37154	-4.40684

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Vaccine Design for the FusionNeoAntigens of MBOAT1-DCDC2

mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-Is.

Fusion gene	Hchr	Hbp	Tchr	Tbp	Start in +/-13AA	End in +/-13AA	FusionNeoAntigen peptide sequence	FusionNeoAntigen RNA sequence
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	10	21	SPTVKPVIHSR	TCTCCCACAGTAAAACCAGTAATCCATAGCAGG
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	12	21	TVKPVIHSR	ACAGTAAAACCAGTAATCCATAGCAGG
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	3	14	FHSLPEPSPTV	TTCCACAGCTTGCCAGAACCTTCTCCCACAGTA
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	4	14	HSLPEPSPTV	CACAGCTTGCCAGAACCTTCTCCCACAGTA
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	5	14	SLPEPSPTV	AGCTTGCCAGAACCTTCTCCCACAGTA
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	5	15	SLPEPSPTVK	AGCTTGCCAGAACCTTCTCCCACAGTAAAA
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	6	14	LPEPSPTV	TTGCCAGAACCTTCTCCCACAGTA
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	6	17	LPEPSPTVKPV	TTGCCAGAACCTTCTCCCACAGTAAAACCAGTA
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	8	17	EPSPTVKPV	GAACCTTCTCCCACAGTAAAACCAGTA

mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-IIs.

Fusion gene	Hchr	Hbp	Tchr	Tbp	Start in +/-13AA	End in +/-13AA	FusionNeoAntigen peptide	FusionNEoAntigen RNA sequence
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	10	25	SPTVKPVIHSRINVS	TCTCCCACAGTAAAACCAGTAATCCATAGCAGGATCAACGTGTCA
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	8	23	EPSPTVKPVIHSRIN	GAACCTTCTCCCACAGTAAAACCAGTAATCCATAGCAGGATCAAC
MBOAT1-DCDC2	chr6	20126747	chr6	24302272	9	24	PSPTVKPVIHSRINV	CCTTCTCCCACAGTAAAACCAGTAATCCATAGCAGGATCAACGTG

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Information of the samples that have these potential fusion neoantigens of MBOAT1-DCDC2

These samples were reported as having these fusion breakpoints. For individual breakpoints, we checked the open reading frames considering multiple gene isoforms and chose the in-frame fusion genes only. Then, we made fusion protein sequences and predicted the fusion neoantigens. These fusion-positive samples may have these potential fusion neoantigens.

Cancer type	Fusion gene	Hchr	Hbp	Henst	Tchr	Tbp	Tenst	Sample
BLCA	MBOAT1-DCDC2	chr6	20126747	ENST00000324607	chr6	24302272	ENST00000378454	TCGA-GV-A3QH

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Potential target of CAR-T therapy development for MBOAT1-DCDC2

Predicted 3D structure. We used RoseTTAFold.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, to provide the retention of the transmembrane domain, we only show the protein feature retention information of those transmembrane features

* Minus value of BPloci means that the break point is located before the CDS.

- In-frame and retained 'Transmembrane'.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

MBOAT1

chr6:20126747

chr6:24302272

ENST00000324607

126_146

238

496.0

Transmembrane

Helical

Hgene

MBOAT1

chr6:20126747

chr6:24302272

ENST00000324607

180_200

238

496.0

Transmembrane

Helical

Hgene

MBOAT1

chr6:20126747

chr6:24302272

ENST00000324607

34_54

238

496.0

Transmembrane

Helical

Hgene

MBOAT1

chr6:20126747

chr6:24302272

ENST00000324607

70_90

238

496.0

Transmembrane

Helical

Hgene

MBOAT1

chr6:20126747

chr6:24302272

ENST00000536798

126_146

238

242.0

Transmembrane

Helical

Hgene

MBOAT1

chr6:20126747

chr6:24302272

ENST00000536798

180_200

238

242.0

Transmembrane

Helical

Hgene

MBOAT1

chr6:20126747

chr6:24302272

ENST00000536798

34_54

238

242.0

Transmembrane

Helical

Hgene

MBOAT1

chr6:20126747

chr6:24302272

ENST00000536798

70_90

238

242.0

Transmembrane

Helical

Hgene

MBOAT1

chr6:20126747

chr6:24302272

ENST00000541730

34_54

347.0

Transmembrane

Helical

Hgene

MBOAT1

chr6:20126747

chr6:24302272

ENST00000541730

70_90

347.0

Transmembrane

Helical

Hgene

MBOAT1

chr6:20126748

chr6:24302272

ENST00000324607

126_146

238

496.0

Transmembrane

Helical

Hgene

MBOAT1

chr6:20126748

chr6:24302272

ENST00000324607

180_200

238

496.0

Transmembrane

Helical

Hgene

MBOAT1

chr6:20126748

chr6:24302272

ENST00000324607

34_54

238

496.0

Transmembrane

Helical

Hgene

MBOAT1

chr6:20126748

chr6:24302272

ENST00000324607

70_90

238

496.0

Transmembrane

Helical

Hgene

MBOAT1

chr6:20126748

chr6:24302272

ENST00000536798

126_146

238

242.0

Transmembrane

Helical

Hgene

MBOAT1

chr6:20126748

chr6:24302272

ENST00000536798

180_200

238

242.0

Transmembrane

Helical

Hgene

MBOAT1

chr6:20126748

chr6:24302272

ENST00000536798

34_54

238

242.0

Transmembrane

Helical

Hgene

MBOAT1

chr6:20126748

chr6:24302272

ENST00000536798

70_90

238

242.0

Transmembrane

Helical

Hgene

MBOAT1

chr6:20126748

chr6:24302272

ENST00000541730

34_54

347.0

Transmembrane

Helical

Hgene

MBOAT1

chr6:20126748

chr6:24302272

ENST00000541730

70_90

347.0

Transmembrane

Helical

Subcellular localization prediction of the transmembrane domain retained fusion proteins
* We used DeepLoc 1.0. The order of the X-axis of the barplot is as follows: Entry_ID, Localization, Type, Nucleus, Cytoplasm, Extracellular, Mitochondrion, Cell_membrane, Endoplasmic_reticulum, Plastid, Golgi.apparatus, Lysosome.Vacuole, Peroxisome. Y-axis is the output score of DeepLoc. Clicking the image will open a new tab with a large image.

Hgene

Hchr

Hbp

Henst

Tgene

Tchr

Tbp

Tenst

DeepLoc result

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Related Drugs to MBOAT1-DCDC2

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to MBOAT1-DCDC2

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source

	Fusion Gene and Fusion Protein Summary
	Fusion Amino Acid Sequences (multiple BPs and multiple gene isoforms)
	Fusion Protein Breakpoint Sequences - (for the Screening of the FusionNeoAntigens)
	Potential FusionNeoAntigens in HLA I - (netMHCpan v4.1 + deepHLApan v1.1)
	Potential FusionNeoAntigens in HLA II - (netMHCIIpan v4.1)
	Fusion Breakpoint 14 AA Peptide Structure - (RoseTTAFold)
	Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D - (Glide)
	Vaccine Design for the FusionNeoAntigens (RNA/protein sequences)
	Potential target of CAR-T therapy development
	Information on the samples that have these potential fusion neoantigens
	Fusion Protein Targeting Drugs - (Manual Curation)
	Fusion Protein Related diseases - (Manual Curation)