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Center for Computational Systems Medicine
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Fusion Gene and Fusion Protein Summary

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Fusion Amino Acid Sequences (multiple BPs and multiple gene isoforms)

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Fusion Protein Breakpoint Sequences - (for the Screening of the FusionNeoAntigens)

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Potential FusionNeoAntigens in HLA I - (netMHCpan v4.1 + deepHLApan v1.1)

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Potential FusionNeoAntigens in HLA II - (netMHCIIpan v4.1)

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Fusion Breakpoint 14 AA Peptide Structure - (RoseTTAFold)

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Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D - (Glide)

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Vaccine Design for the FusionNeoAntigens (RNA/protein sequences)

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Potential target of CAR-T therapy development

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Information on the samples that have these potential fusion neoantigens

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Fusion Protein Targeting Drugs - (Manual Curation)

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Fusion Protein Related diseases - (Manual Curation)

Fusion Protein:MLLT10-ABI1

Fusion Gene and Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: MLLT10-ABI1
FusionPDB ID: 54251
FusionGDB2.0 ID: 54251
HgeneTgene
Gene symbol

MLLT10

ABI1

Gene ID

8028

10006

Gene nameMLLT10 histone lysine methyltransferase DOT1L cofactorabl interactor 1
SynonymsAF10ABI-1|ABLBP4|E3B1|NAP1BP|SSH3BP|SSH3BP1
Cytomap

10p12.31

10p12.1

Type of geneprotein-codingprotein-coding
Descriptionprotein AF-10ALL1-fused gene from chromosome 10 proteinmyeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10myeloid/lymphoid or mixed-lineage leukemia; translocated to, 10type I AF10 proteintype III AF10 protabl interactor 1Abelson interactor 1Abl-interactor protein 1 longabl-binding protein 4eps8 SH3 domain-binding proteininteractor protein AblBP4nap1 binding proteinspectrin SH3 domain-binding protein 1
Modification date2020031320200327
UniProtAcc

P55197

Main function of 5'-partner protein: FUNCTION: Probably involved in transcriptional regulation. In vitro or as fusion protein with KMT2A/MLL1 has transactivation activity. Binds to cruciform DNA. In cells, binding to unmodified histone H3 regulates DOT1L functions including histone H3 'Lys-79' dimethylation (H3K79me2) and gene activation (PubMed:26439302). {ECO:0000269|PubMed:17868029, ECO:0000269|PubMed:26439302}.

Q8IZP0

Main function of 5'-partner protein: FUNCTION: May act in negative regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. May play a role in regulation of EGF-induced Erk pathway activation. Involved in cytoskeletal reorganization and EGFR signaling. Together with EPS8 participates in transduction of signals from Ras to Rac. In vitro, a trimeric complex of ABI1, EPS8 and SOS1 exhibits Rac specific guanine nucleotide exchange factor (GEF) activity and ABI1 seems to act as an adapter in the complex. Regulates ABL1/c-Abl-mediated phosphorylation of ENAH. Recruits WASF1 to lamellipodia and there seems to regulate WASF1 protein level. In brain, seems to regulate the dendritic outgrowth and branching as well as to determine the shape and number of synaptic contacts of developing neurons. {ECO:0000269|PubMed:11003655, ECO:0000269|PubMed:18328268}.
Ensembl transtripts involved in fusion geneENST idsENST00000495130, ENST00000307729, 
ENST00000377059, ENST00000377072, 
ENST00000377091, ENST00000377100, 
ENST00000446906, 		ENST00000346832, 
ENST00000355394, ENST00000359188, 
ENST00000376134, ENST00000376137, 
ENST00000376138, ENST00000376139, 
ENST00000376140, ENST00000376142, 
ENST00000376160, ENST00000376166, 
ENST00000376170, ENST00000490841, 
ENST00000536334, ENST00000473481, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score18 X 15 X 10=270014 X 8 X 5=560
# samples 2413
** MAII scorelog2(24/2700*10)=-3.49185309632968
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(13/560*10)=-2.10691520391651
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Fusion gene context

PubMed: MLLT10 [Title/Abstract] AND ABI1 [Title/Abstract] AND fusion [Title/Abstract]

Fusion neoantigen context

PubMed: MLLT10 [Title/Abstract] AND ABI1 [Title/Abstract] AND neoantigen [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)MLLT10(21827841)-ABI1(27112234), # samples:1
Anticipated loss of major functional domain due to fusion event.MLLT10-ABI1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
MLLT10-ABI1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
MLLT10-ABI1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
MLLT10-ABI1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMLLT10

GO:0045944

positive regulation of transcription by RNA polymerase II

17868029

TgeneABI1

GO:0018108

peptidyl-tyrosine phosphorylation

17101133



check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:21827841/chr10:27112234)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonRetention analysis results of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features, are available here.

check buttonFusion gene breakpoints across MLLT10 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ABI1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


Top

Fusion Amino Acid Sequences


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000446906MLLT10chr1021827841+ENST00000376170ABI1chr1027112234-38045883301826498
ENST00000446906MLLT10chr1021827841+ENST00000359188ABI1chr1027112234-38915883301913527
ENST00000446906MLLT10chr1021827841+ENST00000376142ABI1chr1027112234-39755883301997555
ENST00000446906MLLT10chr1021827841+ENST00000376139ABI1chr1027112234-38795883301901523
ENST00000446906MLLT10chr1021827841+ENST00000376160ABI1chr1027112234-38765883301898522
ENST00000446906MLLT10chr1021827841+ENST00000376166ABI1chr1027112234-37895883301811493
ENST00000446906MLLT10chr1021827841+ENST00000376138ABI1chr1027112234-38075883301829499
ENST00000446906MLLT10chr1021827841+ENST00000355394ABI1chr1027112234-39755883302000556
ENST00000446906MLLT10chr1021827841+ENST00000490841ABI1chr1027112234-34355883301460376
ENST00000446906MLLT10chr1021827841+ENST00000376137ABI1chr1027112234-37175883301742470
ENST00000446906MLLT10chr1021827841+ENST00000346832ABI1chr1027112234-38855883301910526
ENST00000446906MLLT10chr1021827841+ENST00000536334ABI1chr1027112234-36305883301655441
ENST00000446906MLLT10chr1021827841+ENST00000376134ABI1chr1027112234-38945883301919529
ENST00000446906MLLT10chr1021827841+ENST00000376140ABI1chr1027112234-19175883301916528
ENST00000377072MLLT10chr1021827841+ENST00000376170ABI1chr1027112234-38045883301826498
ENST00000377072MLLT10chr1021827841+ENST00000359188ABI1chr1027112234-38915883301913527
ENST00000377072MLLT10chr1021827841+ENST00000376142ABI1chr1027112234-39755883301997555
ENST00000377072MLLT10chr1021827841+ENST00000376139ABI1chr1027112234-38795883301901523
ENST00000377072MLLT10chr1021827841+ENST00000376160ABI1chr1027112234-38765883301898522
ENST00000377072MLLT10chr1021827841+ENST00000376166ABI1chr1027112234-37895883301811493
ENST00000377072MLLT10chr1021827841+ENST00000376138ABI1chr1027112234-38075883301829499
ENST00000377072MLLT10chr1021827841+ENST00000355394ABI1chr1027112234-39755883302000556
ENST00000377072MLLT10chr1021827841+ENST00000490841ABI1chr1027112234-34355883301460376
ENST00000377072MLLT10chr1021827841+ENST00000376137ABI1chr1027112234-37175883301742470
ENST00000377072MLLT10chr1021827841+ENST00000346832ABI1chr1027112234-38855883301910526
ENST00000377072MLLT10chr1021827841+ENST00000536334ABI1chr1027112234-36305883301655441
ENST00000377072MLLT10chr1021827841+ENST00000376134ABI1chr1027112234-38945883301919529
ENST00000377072MLLT10chr1021827841+ENST00000376140ABI1chr1027112234-19175883301916528
ENST00000307729MLLT10chr1021827841+ENST00000376170ABI1chr1027112234-36344181601656498
ENST00000307729MLLT10chr1021827841+ENST00000359188ABI1chr1027112234-37214181601743527
ENST00000307729MLLT10chr1021827841+ENST00000376142ABI1chr1027112234-38054181601827555
ENST00000307729MLLT10chr1021827841+ENST00000376139ABI1chr1027112234-37094181601731523
ENST00000307729MLLT10chr1021827841+ENST00000376160ABI1chr1027112234-37064181601728522
ENST00000307729MLLT10chr1021827841+ENST00000376166ABI1chr1027112234-36194181601641493
ENST00000307729MLLT10chr1021827841+ENST00000376138ABI1chr1027112234-36374181601659499
ENST00000307729MLLT10chr1021827841+ENST00000355394ABI1chr1027112234-38054181601830556
ENST00000307729MLLT10chr1021827841+ENST00000490841ABI1chr1027112234-32654181601290376
ENST00000307729MLLT10chr1021827841+ENST00000376137ABI1chr1027112234-35474181601572470
ENST00000307729MLLT10chr1021827841+ENST00000346832ABI1chr1027112234-37154181601740526
ENST00000307729MLLT10chr1021827841+ENST00000536334ABI1chr1027112234-34604181601485441
ENST00000307729MLLT10chr1021827841+ENST00000376134ABI1chr1027112234-37244181601749529
ENST00000307729MLLT10chr1021827841+ENST00000376140ABI1chr1027112234-17474181601746529
ENST00000377059MLLT10chr1021827841+ENST00000376170ABI1chr1027112234-345624001478492
ENST00000377059MLLT10chr1021827841+ENST00000359188ABI1chr1027112234-354324001565521
ENST00000377059MLLT10chr1021827841+ENST00000376142ABI1chr1027112234-362724001649549
ENST00000377059MLLT10chr1021827841+ENST00000376139ABI1chr1027112234-353124001553517
ENST00000377059MLLT10chr1021827841+ENST00000376160ABI1chr1027112234-352824001550516
ENST00000377059MLLT10chr1021827841+ENST00000376166ABI1chr1027112234-344124001463487
ENST00000377059MLLT10chr1021827841+ENST00000376138ABI1chr1027112234-345924001481493
ENST00000377059MLLT10chr1021827841+ENST00000355394ABI1chr1027112234-362724001652550
ENST00000377059MLLT10chr1021827841+ENST00000490841ABI1chr1027112234-308724001112370
ENST00000377059MLLT10chr1021827841+ENST00000376137ABI1chr1027112234-336924001394464
ENST00000377059MLLT10chr1021827841+ENST00000346832ABI1chr1027112234-353724001562520
ENST00000377059MLLT10chr1021827841+ENST00000536334ABI1chr1027112234-328224001307435
ENST00000377059MLLT10chr1021827841+ENST00000376134ABI1chr1027112234-354624001571523
ENST00000377059MLLT10chr1021827841+ENST00000376140ABI1chr1027112234-156924001568522
ENST00000377100MLLT10chr1021827841+ENST00000376170ABI1chr1027112234-38125963381834498
ENST00000377100MLLT10chr1021827841+ENST00000359188ABI1chr1027112234-38995963381921527
ENST00000377100MLLT10chr1021827841+ENST00000376142ABI1chr1027112234-39835963382005555
ENST00000377100MLLT10chr1021827841+ENST00000376139ABI1chr1027112234-38875963381909523
ENST00000377100MLLT10chr1021827841+ENST00000376160ABI1chr1027112234-38845963381906522
ENST00000377100MLLT10chr1021827841+ENST00000376166ABI1chr1027112234-37975963381819493
ENST00000377100MLLT10chr1021827841+ENST00000376138ABI1chr1027112234-38155963381837499
ENST00000377100MLLT10chr1021827841+ENST00000355394ABI1chr1027112234-39835963382008556
ENST00000377100MLLT10chr1021827841+ENST00000490841ABI1chr1027112234-34435963381468376
ENST00000377100MLLT10chr1021827841+ENST00000376137ABI1chr1027112234-37255963381750470
ENST00000377100MLLT10chr1021827841+ENST00000346832ABI1chr1027112234-38935963381918526
ENST00000377100MLLT10chr1021827841+ENST00000536334ABI1chr1027112234-36385963381663441
ENST00000377100MLLT10chr1021827841+ENST00000376134ABI1chr1027112234-39025963381927529
ENST00000377100MLLT10chr1021827841+ENST00000376140ABI1chr1027112234-19255963381924529
ENST00000377091MLLT10chr1021827841+ENST00000376170ABI1chr1027112234-36324161581654498
ENST00000377091MLLT10chr1021827841+ENST00000359188ABI1chr1027112234-37194161581741527
ENST00000377091MLLT10chr1021827841+ENST00000376142ABI1chr1027112234-38034161581825555
ENST00000377091MLLT10chr1021827841+ENST00000376139ABI1chr1027112234-37074161581729523
ENST00000377091MLLT10chr1021827841+ENST00000376160ABI1chr1027112234-37044161581726522
ENST00000377091MLLT10chr1021827841+ENST00000376166ABI1chr1027112234-36174161581639493
ENST00000377091MLLT10chr1021827841+ENST00000376138ABI1chr1027112234-36354161581657499
ENST00000377091MLLT10chr1021827841+ENST00000355394ABI1chr1027112234-38034161581828556
ENST00000377091MLLT10chr1021827841+ENST00000490841ABI1chr1027112234-32634161581288376
ENST00000377091MLLT10chr1021827841+ENST00000376137ABI1chr1027112234-35454161581570470
ENST00000377091MLLT10chr1021827841+ENST00000346832ABI1chr1027112234-37134161581738526
ENST00000377091MLLT10chr1021827841+ENST00000536334ABI1chr1027112234-34584161581483441
ENST00000377091MLLT10chr1021827841+ENST00000376134ABI1chr1027112234-37224161581747529
ENST00000377091MLLT10chr1021827841+ENST00000376140ABI1chr1027112234-17454161581744529

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000446906ENST00000376170MLLT10chr1021827841+ABI1chr1027112234-8.03E-050.99991965
ENST00000446906ENST00000359188MLLT10chr1021827841+ABI1chr1027112234-9.42E-050.9999057
ENST00000446906ENST00000376142MLLT10chr1021827841+ABI1chr1027112234-0.0001123650.9998876
ENST00000446906ENST00000376139MLLT10chr1021827841+ABI1chr1027112234-8.38E-050.9999162
ENST00000446906ENST00000376160MLLT10chr1021827841+ABI1chr1027112234-8.46E-050.99991536
ENST00000446906ENST00000376166MLLT10chr1021827841+ABI1chr1027112234-7.74E-050.99992263
ENST00000446906ENST00000376138MLLT10chr1021827841+ABI1chr1027112234-8.13E-050.9999187
ENST00000446906ENST00000355394MLLT10chr1021827841+ABI1chr1027112234-9.84E-050.99990153
ENST00000446906ENST00000490841MLLT10chr1021827841+ABI1chr1027112234-5.75E-050.99994254
ENST00000446906ENST00000376137MLLT10chr1021827841+ABI1chr1027112234-7.11E-050.99992895
ENST00000446906ENST00000346832MLLT10chr1021827841+ABI1chr1027112234-0.0001156660.99988437
ENST00000446906ENST00000536334MLLT10chr1021827841+ABI1chr1027112234-6.69E-050.9999331
ENST00000446906ENST00000376134MLLT10chr1021827841+ABI1chr1027112234-8.25E-050.9999175
ENST00000446906ENST00000376140MLLT10chr1021827841+ABI1chr1027112234-0.0026732450.99732673
ENST00000377072ENST00000376170MLLT10chr1021827841+ABI1chr1027112234-8.03E-050.99991965
ENST00000377072ENST00000359188MLLT10chr1021827841+ABI1chr1027112234-9.42E-050.9999057
ENST00000377072ENST00000376142MLLT10chr1021827841+ABI1chr1027112234-0.0001123650.9998876
ENST00000377072ENST00000376139MLLT10chr1021827841+ABI1chr1027112234-8.38E-050.9999162
ENST00000377072ENST00000376160MLLT10chr1021827841+ABI1chr1027112234-8.46E-050.99991536
ENST00000377072ENST00000376166MLLT10chr1021827841+ABI1chr1027112234-7.74E-050.99992263
ENST00000377072ENST00000376138MLLT10chr1021827841+ABI1chr1027112234-8.13E-050.9999187
ENST00000377072ENST00000355394MLLT10chr1021827841+ABI1chr1027112234-9.84E-050.99990153
ENST00000377072ENST00000490841MLLT10chr1021827841+ABI1chr1027112234-5.75E-050.99994254
ENST00000377072ENST00000376137MLLT10chr1021827841+ABI1chr1027112234-7.11E-050.99992895
ENST00000377072ENST00000346832MLLT10chr1021827841+ABI1chr1027112234-0.0001156660.99988437
ENST00000377072ENST00000536334MLLT10chr1021827841+ABI1chr1027112234-6.69E-050.9999331
ENST00000377072ENST00000376134MLLT10chr1021827841+ABI1chr1027112234-8.25E-050.9999175
ENST00000377072ENST00000376140MLLT10chr1021827841+ABI1chr1027112234-0.0026732450.99732673
ENST00000307729ENST00000376170MLLT10chr1021827841+ABI1chr1027112234-7.79E-050.99992204
ENST00000307729ENST00000359188MLLT10chr1021827841+ABI1chr1027112234-9.25E-050.9999075
ENST00000307729ENST00000376142MLLT10chr1021827841+ABI1chr1027112234-0.0001132720.99988675
ENST00000307729ENST00000376139MLLT10chr1021827841+ABI1chr1027112234-8.29E-050.99991715
ENST00000307729ENST00000376160MLLT10chr1021827841+ABI1chr1027112234-8.33E-050.9999167
ENST00000307729ENST00000376166MLLT10chr1021827841+ABI1chr1027112234-7.55E-050.99992454
ENST00000307729ENST00000376138MLLT10chr1021827841+ABI1chr1027112234-7.91E-050.99992085
ENST00000307729ENST00000355394MLLT10chr1021827841+ABI1chr1027112234-9.92E-050.9999008
ENST00000307729ENST00000490841MLLT10chr1021827841+ABI1chr1027112234-5.57E-050.9999443
ENST00000307729ENST00000376137MLLT10chr1021827841+ABI1chr1027112234-6.99E-050.99993
ENST00000307729ENST00000346832MLLT10chr1021827841+ABI1chr1027112234-0.0001148050.9998852
ENST00000307729ENST00000536334MLLT10chr1021827841+ABI1chr1027112234-6.49E-050.99993515
ENST00000307729ENST00000376134MLLT10chr1021827841+ABI1chr1027112234-8.12E-050.9999188
ENST00000307729ENST00000376140MLLT10chr1021827841+ABI1chr1027112234-0.0022450310.997755
ENST00000377059ENST00000376170MLLT10chr1021827841+ABI1chr1027112234-6.91E-050.99993086
ENST00000377059ENST00000359188MLLT10chr1021827841+ABI1chr1027112234-8.45E-050.9999155
ENST00000377059ENST00000376142MLLT10chr1021827841+ABI1chr1027112234-0.0001015020.99989843
ENST00000377059ENST00000376139MLLT10chr1021827841+ABI1chr1027112234-7.63E-050.9999237
ENST00000377059ENST00000376160MLLT10chr1021827841+ABI1chr1027112234-7.65E-050.99992347
ENST00000377059ENST00000376166MLLT10chr1021827841+ABI1chr1027112234-6.78E-050.99993217
ENST00000377059ENST00000376138MLLT10chr1021827841+ABI1chr1027112234-7.09E-050.9999292
ENST00000377059ENST00000355394MLLT10chr1021827841+ABI1chr1027112234-8.84E-050.99991155
ENST00000377059ENST00000490841MLLT10chr1021827841+ABI1chr1027112234-4.87E-050.99995124
ENST00000377059ENST00000376137MLLT10chr1021827841+ABI1chr1027112234-6.13E-050.9999386
ENST00000377059ENST00000346832MLLT10chr1021827841+ABI1chr1027112234-0.0001022970.9998977
ENST00000377059ENST00000536334MLLT10chr1021827841+ABI1chr1027112234-5.47E-050.9999453
ENST00000377059ENST00000376134MLLT10chr1021827841+ABI1chr1027112234-7.45E-050.9999255
ENST00000377059ENST00000376140MLLT10chr1021827841+ABI1chr1027112234-0.0023753880.9976246
ENST00000377100ENST00000376170MLLT10chr1021827841+ABI1chr1027112234-8.10E-050.99991894
ENST00000377100ENST00000359188MLLT10chr1021827841+ABI1chr1027112234-9.49E-050.9999051
ENST00000377100ENST00000376142MLLT10chr1021827841+ABI1chr1027112234-0.00011340.99988663
ENST00000377100ENST00000376139MLLT10chr1021827841+ABI1chr1027112234-8.44E-050.9999156
ENST00000377100ENST00000376160MLLT10chr1021827841+ABI1chr1027112234-8.52E-050.9999149
ENST00000377100ENST00000376166MLLT10chr1021827841+ABI1chr1027112234-7.80E-050.9999219
ENST00000377100ENST00000376138MLLT10chr1021827841+ABI1chr1027112234-8.21E-050.99991786
ENST00000377100ENST00000355394MLLT10chr1021827841+ABI1chr1027112234-9.93E-050.9999007
ENST00000377100ENST00000490841MLLT10chr1021827841+ABI1chr1027112234-5.81E-050.99994195
ENST00000377100ENST00000376137MLLT10chr1021827841+ABI1chr1027112234-7.17E-050.99992824
ENST00000377100ENST00000346832MLLT10chr1021827841+ABI1chr1027112234-0.0001169960.99988294
ENST00000377100ENST00000536334MLLT10chr1021827841+ABI1chr1027112234-6.78E-050.99993217
ENST00000377100ENST00000376134MLLT10chr1021827841+ABI1chr1027112234-8.31E-050.9999169
ENST00000377100ENST00000376140MLLT10chr1021827841+ABI1chr1027112234-0.0027983930.9972017
ENST00000377091ENST00000376170MLLT10chr1021827841+ABI1chr1027112234-7.84E-050.99992156
ENST00000377091ENST00000359188MLLT10chr1021827841+ABI1chr1027112234-9.30E-050.999907
ENST00000377091ENST00000376142MLLT10chr1021827841+ABI1chr1027112234-0.0001135640.9998864
ENST00000377091ENST00000376139MLLT10chr1021827841+ABI1chr1027112234-8.33E-050.9999167
ENST00000377091ENST00000376160MLLT10chr1021827841+ABI1chr1027112234-8.38E-050.9999162
ENST00000377091ENST00000376166MLLT10chr1021827841+ABI1chr1027112234-7.61E-050.99992394
ENST00000377091ENST00000376138MLLT10chr1021827841+ABI1chr1027112234-7.97E-050.99992037
ENST00000377091ENST00000355394MLLT10chr1021827841+ABI1chr1027112234-9.95E-050.99990046
ENST00000377091ENST00000490841MLLT10chr1021827841+ABI1chr1027112234-5.61E-050.99994385
ENST00000377091ENST00000376137MLLT10chr1021827841+ABI1chr1027112234-7.05E-050.99992955
ENST00000377091ENST00000346832MLLT10chr1021827841+ABI1chr1027112234-0.000115310.9998847
ENST00000377091ENST00000536334MLLT10chr1021827841+ABI1chr1027112234-6.54E-050.9999347
ENST00000377091ENST00000376134MLLT10chr1021827841+ABI1chr1027112234-8.17E-050.99991834
ENST00000377091ENST00000376140MLLT10chr1021827841+ABI1chr1027112234-0.0022734360.9977266

check button Predicted full-length fusion amino acid sequences. For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among all the predicted ones.

Get the fusion protein sequences from here.

Fusion protein sequence information is available in the fasta format.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

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Fusion Protein Breakpoint Sequences for MLLT10-ABI1

check button +/-13 AA sequence from the breakpoints of the fusion protein sequences.
HgeneHchrHbpTgeneTchrTbpLength(fusion protein)BP in fusion proteinPeptide
MLLT10chr1021827841ABI1chr102711223424080CRKCESQERAARVATDKRKALEETKA
MLLT10chr1021827841ABI1chr102711223441686CRKCESQERAARVATDKRKALEETKA
MLLT10chr1021827841ABI1chr102711223441886CRKCESQERAARVATDKRKALEETKA
MLLT10chr1021827841ABI1chr102711223458886CRKCESQERAARVATDKRKALEETKA
MLLT10chr1021827841ABI1chr102711223459686CRKCESQERAARVATDKRKALEETKA

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Potential FusionNeoAntigen Information of MLLT10-ABI1 in HLA I

check button Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.
MLLT10-ABI1_21827841_27112234.msa

check button Potential FusionNeoAntigen Information
* We used NetMHCpan v4.1 (%rank<0.5) and deepHLApan v1.1 (immunogenic score>0.5)
Fusion geneHchrHbpTgeneTchrTbpHLA IFusionNeoAntigen peptideBinding scoreImmunogenic scoreNeoantigen start (at BP 13)Neoantigen end (at BP 13)
MLLT10-ABI1chr1021827841chr1027112234418HLA-B45:01QERAARVAT0.8990.9882615
MLLT10-ABI1chr1021827841chr1027112234418HLA-B14:02VATDKRKAL0.89180.66031221
MLLT10-ABI1chr1021827841chr1027112234418HLA-B14:01VATDKRKAL0.89180.66031221
MLLT10-ABI1chr1021827841chr1027112234418HLA-B50:02QERAARVAT0.84130.8826615
MLLT10-ABI1chr1021827841chr1027112234418HLA-B50:01QERAARVAT0.14490.9909615
MLLT10-ABI1chr1021827841chr1027112234418HLA-C03:19VATDKRKAL0.99440.98121221
MLLT10-ABI1chr1021827841chr1027112234418HLA-C03:08VATDKRKAL0.99180.87051221
MLLT10-ABI1chr1021827841chr1027112234418HLA-C03:07VATDKRKAL0.98810.97591221
MLLT10-ABI1chr1021827841chr1027112234418HLA-B27:14ARVATDKRK0.97230.68331019
MLLT10-ABI1chr1021827841chr1027112234418HLA-C15:06VATDKRKAL0.97090.871221
MLLT10-ABI1chr1021827841chr1027112234418HLA-C12:12VATDKRKAL0.95040.8891221
MLLT10-ABI1chr1021827841chr1027112234418HLA-C06:03VATDKRKAL0.93880.98811221
MLLT10-ABI1chr1021827841chr1027112234418HLA-C12:04VATDKRKAL0.93430.99081221
MLLT10-ABI1chr1021827841chr1027112234418HLA-B14:03VATDKRKAL0.90540.7061221
MLLT10-ABI1chr1021827841chr1027112234418HLA-C01:17VATDKRKAL0.85140.95981221
MLLT10-ABI1chr1021827841chr1027112234418HLA-C01:30VATDKRKAL0.74950.96671221
MLLT10-ABI1chr1021827841chr1027112234418HLA-C08:13VATDKRKAL0.72680.9641221
MLLT10-ABI1chr1021827841chr1027112234418HLA-C08:04VATDKRKAL0.72680.9641221
MLLT10-ABI1chr1021827841chr1027112234418HLA-C02:06VATDKRKAL0.6380.96151221
MLLT10-ABI1chr1021827841chr1027112234418HLA-C03:14VATDKRKAL0.46190.97731221
MLLT10-ABI1chr1021827841chr1027112234418HLA-C08:03VATDKRKAL0.31190.97631221
MLLT10-ABI1chr1021827841chr1027112234418HLA-B07:04RVATDKRKAL0.90090.50961121
MLLT10-ABI1chr1021827841chr1027112234418HLA-C03:04VATDKRKAL0.99610.98571221
MLLT10-ABI1chr1021827841chr1027112234418HLA-C03:03VATDKRKAL0.99610.98571221
MLLT10-ABI1chr1021827841chr1027112234418HLA-C03:67VATDKRKAL0.99280.97411221
MLLT10-ABI1chr1021827841chr1027112234418HLA-C03:17VATDKRKAL0.99110.97181221
MLLT10-ABI1chr1021827841chr1027112234418HLA-C03:05VATDKRKAL0.99050.92761221
MLLT10-ABI1chr1021827841chr1027112234418HLA-C06:06VATDKRKAL0.98510.99291221
MLLT10-ABI1chr1021827841chr1027112234418HLA-C03:02VATDKRKAL0.93550.97461221
MLLT10-ABI1chr1021827841chr1027112234418HLA-C12:03VATDKRKAL0.9330.97571221
MLLT10-ABI1chr1021827841chr1027112234418HLA-B07:13VATDKRKAL0.92070.81661221
MLLT10-ABI1chr1021827841chr1027112234418HLA-C01:02VATDKRKAL0.90160.95981221
MLLT10-ABI1chr1021827841chr1027112234418HLA-C01:03VATDKRKAL0.89450.93951221
MLLT10-ABI1chr1021827841chr1027112234418HLA-C16:04VATDKRKAL0.89020.97171221
MLLT10-ABI1chr1021827841chr1027112234418HLA-C07:04VATDKRKAL0.83140.95881221
MLLT10-ABI1chr1021827841chr1027112234418HLA-C03:06VATDKRKAL0.82230.98491221
MLLT10-ABI1chr1021827841chr1027112234418HLA-C12:02VATDKRKAL0.81090.96951221
MLLT10-ABI1chr1021827841chr1027112234418HLA-C16:01VATDKRKAL0.69970.97951221
MLLT10-ABI1chr1021827841chr1027112234418HLA-C16:02VATDKRKAL0.66030.9891221
MLLT10-ABI1chr1021827841chr1027112234418HLA-C08:01VATDKRKAL0.31190.97631221
MLLT10-ABI1chr1021827841chr1027112234418HLA-B50:04QERAARVAT0.14490.9909615
MLLT10-ABI1chr1021827841chr1027112234418HLA-B50:05QERAARVAT0.14490.9909615

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Potential FusionNeoAntigen Information of MLLT10-ABI1 in HLA II

check button Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.
MLLT10-ABI1_21827841_27112234.msa

check button Potential FusionNeoAntigen Information
* We used NetMHCIIpan v4.1 (%rank<0.5).
Fusion geneHchrHbpTgeneTchrTbpHLA IIFusionNeoAntigen peptideNeoantigen start (at BP 13)Neoantigen end (at BP 13)
MLLT10-ABI1chr1021827841chr1027112234418DRB1-0301AARVATDKRKALEET924
MLLT10-ABI1chr1021827841chr1027112234418DRB1-0301RAARVATDKRKALEE823
MLLT10-ABI1chr1021827841chr1027112234418DRB1-0301ERAARVATDKRKALE722
MLLT10-ABI1chr1021827841chr1027112234418DRB1-0301ARVATDKRKALEETK1025
MLLT10-ABI1chr1021827841chr1027112234418DRB1-0303AARVATDKRKALEET924
MLLT10-ABI1chr1021827841chr1027112234418DRB1-0303RAARVATDKRKALEE823
MLLT10-ABI1chr1021827841chr1027112234418DRB1-0305AARVATDKRKALEET924
MLLT10-ABI1chr1021827841chr1027112234418DRB1-0305RAARVATDKRKALEE823
MLLT10-ABI1chr1021827841chr1027112234418DRB1-0307AARVATDKRKALEET924
MLLT10-ABI1chr1021827841chr1027112234418DRB1-0307RAARVATDKRKALEE823
MLLT10-ABI1chr1021827841chr1027112234418DRB1-0307ERAARVATDKRKALE722
MLLT10-ABI1chr1021827841chr1027112234418DRB1-0307ARVATDKRKALEETK1025
MLLT10-ABI1chr1021827841chr1027112234418DRB1-0310AARVATDKRKALEET924
MLLT10-ABI1chr1021827841chr1027112234418DRB1-0310RAARVATDKRKALEE823
MLLT10-ABI1chr1021827841chr1027112234418DRB1-0310ERAARVATDKRKALE722
MLLT10-ABI1chr1021827841chr1027112234418DRB1-0310ARVATDKRKALEETK1025
MLLT10-ABI1chr1021827841chr1027112234418DRB1-0313AARVATDKRKALEET924
MLLT10-ABI1chr1021827841chr1027112234418DRB1-0313RAARVATDKRKALEE823
MLLT10-ABI1chr1021827841chr1027112234418DRB1-0313ERAARVATDKRKALE722
MLLT10-ABI1chr1021827841chr1027112234418DRB1-0313ARVATDKRKALEETK1025
MLLT10-ABI1chr1021827841chr1027112234418DRB1-0315AARVATDKRKALEET924
MLLT10-ABI1chr1021827841chr1027112234418DRB1-0315RAARVATDKRKALEE823
MLLT10-ABI1chr1021827841chr1027112234418DRB1-0315ERAARVATDKRKALE722
MLLT10-ABI1chr1021827841chr1027112234418DRB1-0315ARVATDKRKALEETK1025
MLLT10-ABI1chr1021827841chr1027112234418DRB1-0318AARVATDKRKALEET924
MLLT10-ABI1chr1021827841chr1027112234418DRB1-0318RAARVATDKRKALEE823
MLLT10-ABI1chr1021827841chr1027112234418DRB1-0318ERAARVATDKRKALE722
MLLT10-ABI1chr1021827841chr1027112234418DRB1-0318ARVATDKRKALEETK1025
MLLT10-ABI1chr1021827841chr1027112234418DRB1-0320AARVATDKRKALEET924
MLLT10-ABI1chr1021827841chr1027112234418DRB1-0320RAARVATDKRKALEE823
MLLT10-ABI1chr1021827841chr1027112234418DRB1-0320ERAARVATDKRKALE722
MLLT10-ABI1chr1021827841chr1027112234418DRB1-0320ARVATDKRKALEETK1025
MLLT10-ABI1chr1021827841chr1027112234418DRB1-0322AARVATDKRKALEET924
MLLT10-ABI1chr1021827841chr1027112234418DRB1-0322RAARVATDKRKALEE823
MLLT10-ABI1chr1021827841chr1027112234418DRB1-0322ERAARVATDKRKALE722
MLLT10-ABI1chr1021827841chr1027112234418DRB1-0322ARVATDKRKALEETK1025
MLLT10-ABI1chr1021827841chr1027112234418DRB1-0324AARVATDKRKALEET924
MLLT10-ABI1chr1021827841chr1027112234418DRB1-0324RAARVATDKRKALEE823
MLLT10-ABI1chr1021827841chr1027112234418DRB1-0324ERAARVATDKRKALE722
MLLT10-ABI1chr1021827841chr1027112234418DRB1-0324ARVATDKRKALEETK1025
MLLT10-ABI1chr1021827841chr1027112234418DRB1-0326AARVATDKRKALEET924
MLLT10-ABI1chr1021827841chr1027112234418DRB1-0326RAARVATDKRKALEE823
MLLT10-ABI1chr1021827841chr1027112234418DRB1-0328AARVATDKRKALEET924
MLLT10-ABI1chr1021827841chr1027112234418DRB1-0328RAARVATDKRKALEE823
MLLT10-ABI1chr1021827841chr1027112234418DRB1-0328ERAARVATDKRKALE722
MLLT10-ABI1chr1021827841chr1027112234418DRB1-0328ARVATDKRKALEETK1025
MLLT10-ABI1chr1021827841chr1027112234418DRB1-0330AARVATDKRKALEET924
MLLT10-ABI1chr1021827841chr1027112234418DRB1-0330RAARVATDKRKALEE823
MLLT10-ABI1chr1021827841chr1027112234418DRB1-0330ERAARVATDKRKALE722
MLLT10-ABI1chr1021827841chr1027112234418DRB1-0330ARVATDKRKALEETK1025
MLLT10-ABI1chr1021827841chr1027112234418DRB1-0332AARVATDKRKALEET924
MLLT10-ABI1chr1021827841chr1027112234418DRB1-0332RAARVATDKRKALEE823
MLLT10-ABI1chr1021827841chr1027112234418DRB1-0332ERAARVATDKRKALE722
MLLT10-ABI1chr1021827841chr1027112234418DRB1-0332ARVATDKRKALEETK1025
MLLT10-ABI1chr1021827841chr1027112234418DRB1-0334AARVATDKRKALEET924
MLLT10-ABI1chr1021827841chr1027112234418DRB1-0334RAARVATDKRKALEE823
MLLT10-ABI1chr1021827841chr1027112234418DRB1-0334ERAARVATDKRKALE722
MLLT10-ABI1chr1021827841chr1027112234418DRB1-0334ARVATDKRKALEETK1025
MLLT10-ABI1chr1021827841chr1027112234418DRB1-0336AARVATDKRKALEET924
MLLT10-ABI1chr1021827841chr1027112234418DRB1-0336RAARVATDKRKALEE823
MLLT10-ABI1chr1021827841chr1027112234418DRB1-0336ERAARVATDKRKALE722
MLLT10-ABI1chr1021827841chr1027112234418DRB1-0336ARVATDKRKALEETK1025
MLLT10-ABI1chr1021827841chr1027112234418DRB1-0340AARVATDKRKALEET924
MLLT10-ABI1chr1021827841chr1027112234418DRB1-0340RAARVATDKRKALEE823
MLLT10-ABI1chr1021827841chr1027112234418DRB1-0342AARVATDKRKALEET924
MLLT10-ABI1chr1021827841chr1027112234418DRB1-0342RAARVATDKRKALEE823
MLLT10-ABI1chr1021827841chr1027112234418DRB1-0344AARVATDKRKALEET924
MLLT10-ABI1chr1021827841chr1027112234418DRB1-0344RAARVATDKRKALEE823
MLLT10-ABI1chr1021827841chr1027112234418DRB1-0344ERAARVATDKRKALE722
MLLT10-ABI1chr1021827841chr1027112234418DRB1-0344ARVATDKRKALEETK1025
MLLT10-ABI1chr1021827841chr1027112234418DRB1-0346AARVATDKRKALEET924
MLLT10-ABI1chr1021827841chr1027112234418DRB1-0346RAARVATDKRKALEE823
MLLT10-ABI1chr1021827841chr1027112234418DRB1-0346ERAARVATDKRKALE722
MLLT10-ABI1chr1021827841chr1027112234418DRB1-0346ARVATDKRKALEETK1025
MLLT10-ABI1chr1021827841chr1027112234418DRB1-0348AARVATDKRKALEET924
MLLT10-ABI1chr1021827841chr1027112234418DRB1-0348RAARVATDKRKALEE823
MLLT10-ABI1chr1021827841chr1027112234418DRB1-0348ERAARVATDKRKALE722
MLLT10-ABI1chr1021827841chr1027112234418DRB1-0348ARVATDKRKALEETK1025
MLLT10-ABI1chr1021827841chr1027112234418DRB1-0350AARVATDKRKALEET924
MLLT10-ABI1chr1021827841chr1027112234418DRB1-0350RAARVATDKRKALEE823
MLLT10-ABI1chr1021827841chr1027112234418DRB1-0350ERAARVATDKRKALE722
MLLT10-ABI1chr1021827841chr1027112234418DRB1-0350ARVATDKRKALEETK1025
MLLT10-ABI1chr1021827841chr1027112234418DRB1-0352AARVATDKRKALEET924
MLLT10-ABI1chr1021827841chr1027112234418DRB1-0352RAARVATDKRKALEE823
MLLT10-ABI1chr1021827841chr1027112234418DRB1-0352ERAARVATDKRKALE722
MLLT10-ABI1chr1021827841chr1027112234418DRB1-0352ARVATDKRKALEETK1025
MLLT10-ABI1chr1021827841chr1027112234418DRB1-0354AARVATDKRKALEET924
MLLT10-ABI1chr1021827841chr1027112234418DRB1-0354RAARVATDKRKALEE823
MLLT10-ABI1chr1021827841chr1027112234418DRB1-0354ERAARVATDKRKALE722
MLLT10-ABI1chr1021827841chr1027112234418DRB1-0354ARVATDKRKALEETK1025
MLLT10-ABI1chr1021827841chr1027112234418DRB1-1107AARVATDKRKALEET924
MLLT10-ABI1chr1021827841chr1027112234418DRB1-1107RAARVATDKRKALEE823
MLLT10-ABI1chr1021827841chr1027112234418DRB1-1107ERAARVATDKRKALE722
MLLT10-ABI1chr1021827841chr1027112234418DRB1-1107ARVATDKRKALEETK1025
MLLT10-ABI1chr1021827841chr1027112234418DRB1-1179AARVATDKRKALEET924
MLLT10-ABI1chr1021827841chr1027112234418DRB1-1371AARVATDKRKALEET924
MLLT10-ABI1chr1021827841chr1027112234418DRB1-1381AARVATDKRKALEET924
MLLT10-ABI1chr1021827841chr1027112234418DRB1-1394AARVATDKRKALEET924
MLLT10-ABI1chr1021827841chr1027112234418DRB1-1394RAARVATDKRKALEE823
MLLT10-ABI1chr1021827841chr1027112234418DRB1-1416AARVATDKRKALEET924
MLLT10-ABI1chr1021827841chr1027112234418DRB1-1421AARVATDKRKALEET924
MLLT10-ABI1chr1021827841chr1027112234418DRB1-1421RAARVATDKRKALEE823
MLLT10-ABI1chr1021827841chr1027112234418DRB1-1438AARVATDKRKALEET924
MLLT10-ABI1chr1021827841chr1027112234418DRB1-1438RAARVATDKRKALEE823
MLLT10-ABI1chr1021827841chr1027112234418DRB1-1476AARVATDKRKALEET924
MLLT10-ABI1chr1021827841chr1027112234418DRB1-1476RAARVATDKRKALEE823
MLLT10-ABI1chr1021827841chr1027112234418DRB1-1476ERAARVATDKRKALE722
MLLT10-ABI1chr1021827841chr1027112234418DRB1-1479AARVATDKRKALEET924
MLLT10-ABI1chr1021827841chr1027112234418DRB1-1479RAARVATDKRKALEE823
MLLT10-ABI1chr1021827841chr1027112234418DRB1-1479ERAARVATDKRKALE722
MLLT10-ABI1chr1021827841chr1027112234418DRB1-1482AARVATDKRKALEET924
MLLT10-ABI1chr1021827841chr1027112234418DRB1-1482RAARVATDKRKALEE823
MLLT10-ABI1chr1021827841chr1027112234418DRB1-1495AARVATDKRKALEET924
MLLT10-ABI1chr1021827841chr1027112234418DRB1-1495RAARVATDKRKALEE823

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Fusion breakpoint peptide structures of MLLT10-ABI1

check button3D structures of the fusion breakpoint peptide of 14AA sequence that have potential fusion neoantigens
* The minimum length of the amino acid sequence in RoseTTAFold is 14AA. Here, we predicted the 14AA fusion protein breakpoint sequence not the fusion neoantigen peptide, which is shorter than 14 AA.
File nameBPseqHgeneTgeneHchrHbpTchrTbpAAlen
7244QERAARVATDKRKAMLLT10ABI1chr1021827841chr1027112234418

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Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D of MLLT10-ABI1

check buttonVirtual screening between 25 HLAs (from PDB) and FusionNeoAntigens
* We used Glide to predict the interaction between HLAs and neoantigens.
HLA allelePDB IDFile nameBPseqDocking scoreGlide score
HLA-B14:023BVN7244QERAARVATDKRKA-7.9962-8.1096
HLA-B14:023BVN7244QERAARVATDKRKA-5.70842-6.74372
HLA-B52:013W397244QERAARVATDKRKA-6.83737-6.95077
HLA-B52:013W397244QERAARVATDKRKA-4.4836-5.5189
HLA-A11:014UQ27244QERAARVATDKRKA-10.0067-10.1201
HLA-A11:014UQ27244QERAARVATDKRKA-9.03915-10.0745
HLA-A24:025HGA7244QERAARVATDKRKA-6.56204-6.67544
HLA-A24:025HGA7244QERAARVATDKRKA-5.42271-6.45801
HLA-B44:053DX87244QERAARVATDKRKA-7.85648-8.89178
HLA-B44:053DX87244QERAARVATDKRKA-5.3978-5.5112
HLA-A02:016TDR7244QERAARVATDKRKA-3.37154-4.40684

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Vaccine Design for the FusionNeoAntigens of MLLT10-ABI1

check button mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-Is.
Fusion geneHchrHbpTchrTbpStart in +/-13AAEnd in +/-13AAFusionNeoAntigen peptide sequenceFusionNeoAntigen RNA sequence
MLLT10-ABI1chr1021827841chr10271122341019ARVATDKRKGCCAGAGTGGCTACAGACAAGAGAAAA
MLLT10-ABI1chr1021827841chr10271122341121RVATDKRKALAGAGTGGCTACAGACAAGAGAAAAGCTTTA
MLLT10-ABI1chr1021827841chr10271122341221VATDKRKALGTGGCTACAGACAAGAGAAAAGCTTTA
MLLT10-ABI1chr1021827841chr1027112234615QERAARVATCAGGAGAGAGCAGCCAGAGTGGCTACA

check button mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-IIs.
Fusion geneHchrHbpTchrTbpStart in +/-13AAEnd in +/-13AAFusionNeoAntigen peptideFusionNEoAntigen RNA sequence
MLLT10-ABI1chr1021827841chr10271122341025ARVATDKRKALEETKGCCAGAGTGGCTACAGACAAGAGAAAAGCTTTAGAGGAGACCAAA
MLLT10-ABI1chr1021827841chr1027112234722ERAARVATDKRKALEGAGAGAGCAGCCAGAGTGGCTACAGACAAGAGAAAAGCTTTAGAG
MLLT10-ABI1chr1021827841chr1027112234823RAARVATDKRKALEEAGAGCAGCCAGAGTGGCTACAGACAAGAGAAAAGCTTTAGAGGAG
MLLT10-ABI1chr1021827841chr1027112234924AARVATDKRKALEETGCAGCCAGAGTGGCTACAGACAAGAGAAAAGCTTTAGAGGAGACC

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Information of the samples that have these potential fusion neoantigens of MLLT10-ABI1

check button These samples were reported as having these fusion breakpoints. For individual breakpoints, we checked the open reading frames considering multiple gene isoforms and chose the in-frame fusion genes only. Then, we made fusion protein sequences and predicted the fusion neoantigens. These fusion-positive samples may have these potential fusion neoantigens.
Cancer typeFusion geneHchrHbpHenstTchrTbpTenstSample
STADMLLT10-ABI1chr1021827841ENST00000307729chr1027112234ENST00000346832TCGA-BR-8366-01A

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Potential target of CAR-T therapy development for MLLT10-ABI1

check button Predicted 3D structure. We used RoseTTAFold.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, to provide the retention of the transmembrane domain, we only show the protein feature retention information of those transmembrane features


* Minus value of BPloci means that the break point is located before the CDS.
- In-frame and retained 'Transmembrane'.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

check button Subcellular localization prediction of the transmembrane domain retained fusion proteins
* We used DeepLoc 1.0. The order of the X-axis of the barplot is as follows: Entry_ID, Localization, Type, Nucleus, Cytoplasm, Extracellular, Mitochondrion, Cell_membrane, Endoplasmic_reticulum, Plastid, Golgi.apparatus, Lysosome.Vacuole, Peroxisome. Y-axis is the output score of DeepLoc. Clicking the image will open a new tab with a large image.
HgeneHchrHbpHenstTgeneTchrTbpTenstDeepLoc result

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Related Drugs to MLLT10-ABI1

check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to MLLT10-ABI1

check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneMLLT10C0007134Renal Cell Carcinoma1CTD_human
HgeneMLLT10C0025202melanoma1CTD_human
HgeneMLLT10C0025286Meningioma1CTD_human
HgeneMLLT10C0205834Meningiomas, Multiple1CTD_human
HgeneMLLT10C0259785Malignant Meningioma1CTD_human
HgeneMLLT10C0279702Conventional (Clear Cell) Renal Cell Carcinoma1CTD_human
HgeneMLLT10C0281784Benign Meningioma1CTD_human
HgeneMLLT10C0334605Meningothelial meningioma1CTD_human
HgeneMLLT10C0334606Fibrous Meningioma1CTD_human
HgeneMLLT10C0334607Psammomatous Meningioma1CTD_human
HgeneMLLT10C0334608Angiomatous Meningioma1CTD_human
HgeneMLLT10C0334609Hemangioblastic Meningioma1CTD_human
HgeneMLLT10C0334610Hemangiopericytic Meningioma1CTD_human
HgeneMLLT10C0334611Transitional Meningioma1CTD_human
HgeneMLLT10C0347515Spinal Meningioma1CTD_human
HgeneMLLT10C0349604Intracranial Meningioma1CTD_human
HgeneMLLT10C0431121Clear Cell Meningioma1CTD_human
HgeneMLLT10C0457190Xanthomatous Meningioma1CTD_human
HgeneMLLT10C0751303Cerebral Convexity Meningioma1CTD_human
HgeneMLLT10C0751304Parasagittal Meningioma1CTD_human
HgeneMLLT10C1266042Chromophobe Renal Cell Carcinoma1CTD_human
HgeneMLLT10C1266043Sarcomatoid Renal Cell Carcinoma1CTD_human
HgeneMLLT10C1266044Collecting Duct Carcinoma of the Kidney1CTD_human
HgeneMLLT10C1306837Papillary Renal Cell Carcinoma1CTD_human
HgeneMLLT10C1334261Intraorbital Meningioma1CTD_human
HgeneMLLT10C1334271Intraventricular Meningioma1CTD_human
HgeneMLLT10C1335107Olfactory Groove Meningioma1CTD_human
HgeneMLLT10C1384406Secretory meningioma1CTD_human
HgeneMLLT10C1384408Microcystic meningioma1CTD_human
HgeneMLLT10C1527197Angioblastic Meningioma1CTD_human
HgeneMLLT10C1565950Posterior Fossa Meningioma1CTD_human
HgeneMLLT10C1565951Sphenoid Wing Meningioma1CTD_human
HgeneMLLT10C1961099Precursor T-Cell Lymphoblastic Leukemia-Lymphoma1ORPHANET
HgeneMLLT10C3163622Papillary Meningioma1CTD_human
TgeneABI1C0019193Hepatitis, Toxic1CTD_human
TgeneABI1C0860207Drug-Induced Liver Disease1CTD_human
TgeneABI1C1262760Hepatitis, Drug-Induced1CTD_human
TgeneABI1C3658290Drug-Induced Acute Liver Injury1CTD_human
TgeneABI1C4277682Chemical and Drug Induced Liver Injury1CTD_human
TgeneABI1C4279912Chemically-Induced Liver Toxicity1CTD_human