FusionNeoAntigen Logo

Home

Download

Statistics

Examples

Help

Contact

Terms of Use
Center for Computational Systems Medicine
leaf

Fusion Gene and Fusion Protein Summary

leaf

Fusion Amino Acid Sequences (multiple BPs and multiple gene isoforms)

leaf

Fusion Protein Breakpoint Sequences - (for the Screening of the FusionNeoAntigens)

leaf

Potential FusionNeoAntigens in HLA I - (netMHCpan v4.1 + deepHLApan v1.1)

leaf

Potential FusionNeoAntigens in HLA II - (netMHCIIpan v4.1)

leaf

Fusion Breakpoint 14 AA Peptide Structure - (RoseTTAFold)

leaf

Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D - (Glide)

leaf

Vaccine Design for the FusionNeoAntigens (RNA/protein sequences)

leaf

Potential target of CAR-T therapy development

leaf

Information on the samples that have these potential fusion neoantigens

leaf

Fusion Protein Targeting Drugs - (Manual Curation)

leaf

Fusion Protein Related diseases - (Manual Curation)

Fusion Protein:MRPL44-ABCG1

Fusion Gene and Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: MRPL44-ABCG1
FusionPDB ID: 55055
FusionGDB2.0 ID: 55055
HgeneTgene
Gene symbol

MRPL44

ABCG1

Gene ID

65080

9619

Gene namemitochondrial ribosomal protein L44ATP binding cassette subfamily G member 1
SynonymsCOXPD16|L44MT|MRP-L44ABC8|WHITE1
Cytomap

2q36.1

21q22.3

Type of geneprotein-codingprotein-coding
Description39S ribosomal protein L44, mitochondrialmitochondrial large ribosomal subunit protein mL44ATP-binding cassette sub-family G member 1ABC transporter 8ATP-binding cassette transporter 8ATP-binding cassette transporter member 1 of subfamily GATP-binding cassette, sub-family G (WHITE), member 1homolog of Drosophila whitewhite protein homolog
Modification date2020031320200329
UniProtAcc

Q9H9J2

Main function of 5'-partner protein: FUNCTION: Component of the 39S subunit of mitochondrial ribosome. May have a function in the assembly/stability of nascent mitochondrial polypeptides exiting the ribosome. {ECO:0000269|PubMed:23315540}.

P45844

Main function of 5'-partner protein: FUNCTION: Catalyzes the efflux of phospholipids such as sphingomyelin, cholesterol and its oxygenated derivatives like 7beta-hydroxycholesterol and this transport is coupled to hydrlysis of ATP (PubMed:17408620, PubMed:24576892). The lipid efflux is ALB-dependent (PubMed:16702602). Is an active component of the macrophage lipid export complex. Could also be involved in intracellular lipid transport processes. The role in cellular lipid homeostasis may not be limited to macrophages. Prevents cell death by transporting cytotoxic 7beta-hydroxycholesterol (PubMed:17408620). {ECO:0000269|PubMed:16702602, ECO:0000269|PubMed:17408620, ECO:0000269|PubMed:24576892}.
Ensembl transtripts involved in fusion geneENST idsENST00000258383, ENST00000343687, 
ENST00000347800, ENST00000361802, 
ENST00000398449, ENST00000462050, 
ENST00000340588, ENST00000398437, 
ENST00000398457, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score2 X 2 X 2=89 X 5 X 8=360
# samples 210
** MAII scorelog2(2/8*10)=1.32192809488736log2(10/360*10)=-1.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Fusion gene context

PubMed: MRPL44 [Title/Abstract] AND ABCG1 [Title/Abstract] AND fusion [Title/Abstract]

Fusion neoantigen context

PubMed: MRPL44 [Title/Abstract] AND ABCG1 [Title/Abstract] AND neoantigen [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)MRPL44(224824719)-ABCG1(43645781), # samples:1
Anticipated loss of major functional domain due to fusion event.MRPL44-ABCG1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
MRPL44-ABCG1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
MRPL44-ABCG1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
MRPL44-ABCG1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneABCG1

GO:0008203

cholesterol metabolic process

15994327

TgeneABCG1

GO:0033344

cholesterol efflux

15994327

TgeneABCG1

GO:0033993

response to lipid

16556852

TgeneABCG1

GO:0034436

glycoprotein transport

17293612

TgeneABCG1

GO:0042632

cholesterol homeostasis

15994327

TgeneABCG1

GO:0042987

amyloid precursor protein catabolic process

17293612

TgeneABCG1

GO:0050714

positive regulation of protein secretion

17293612

TgeneABCG1

GO:1902004

positive regulation of amyloid-beta formation

17293612



check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:224824719/chr21:43645781)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonRetention analysis results of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features, are available here.

check buttonFusion gene breakpoints across MRPL44 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ABCG1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


Top

Fusion Amino Acid Sequences


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000258383MRPL44chr2224824719-ENST00000398457ABCG1chr2143645781+3528717692675868

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000258383ENST00000398457MRPL44chr2224824719-ABCG1chr2143645781+0.0012420360.99875796

check button Predicted full-length fusion amino acid sequences. For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among all the predicted ones.

Get the fusion protein sequences from here.

Fusion protein sequence information is available in the fasta format.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

Top

Fusion Protein Breakpoint Sequences for MRPL44-ABCG1

check button +/-13 AA sequence from the breakpoints of the fusion protein sequences.
HgeneHchrHbpTgeneTchrTbpLength(fusion protein)BP in fusion proteinPeptide
MRPL44chr2224824719ABCG1chr2143645781717216QSSGPERTALFIRNASSYSAEMTEPK

Top

Potential FusionNeoAntigen Information of MRPL44-ABCG1 in HLA I

check button Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.
MRPL44-ABCG1_224824719_43645781.msa

check button Potential FusionNeoAntigen Information
* We used NetMHCpan v4.1 (%rank<0.5) and deepHLApan v1.1 (immunogenic score>0.5)
Fusion geneHchrHbpTgeneTchrTbpHLA IFusionNeoAntigen peptideBinding scoreImmunogenic scoreNeoantigen start (at BP 13)Neoantigen end (at BP 13)
MRPL44-ABCG1chr2224824719chr2143645781717HLA-B15:02FIRNASSY0.99540.68141018
MRPL44-ABCG1chr2224824719chr2143645781717HLA-B39:06IRNASSYSA0.99290.72991120
MRPL44-ABCG1chr2224824719chr2143645781717HLA-A30:08RTALFIRNA0.98820.703615
MRPL44-ABCG1chr2224824719chr2143645781717HLA-B15:02LFIRNASSY0.90350.6785918
MRPL44-ABCG1chr2224824719chr2143645781717HLA-B15:01ALFIRNASSY0.99980.7816818
MRPL44-ABCG1chr2224824719chr2143645781717HLA-B15:25ALFIRNASSY0.99360.7573818
MRPL44-ABCG1chr2224824719chr2143645781717HLA-B15:02ALFIRNASSY0.98640.7846818
MRPL44-ABCG1chr2224824719chr2143645781717HLA-B39:06FIRNASSYSA0.68370.72021020
MRPL44-ABCG1chr2224824719chr2143645781717HLA-B73:01IRNASSYSA0.99480.57851120
MRPL44-ABCG1chr2224824719chr2143645781717HLA-B27:14IRNASSYSA0.99460.70781120
MRPL44-ABCG1chr2224824719chr2143645781717HLA-B15:21LFIRNASSY0.90950.6844918
MRPL44-ABCG1chr2224824719chr2143645781717HLA-B15:07ALFIRNASSY0.99940.531818
MRPL44-ABCG1chr2224824719chr2143645781717HLA-B15:04ALFIRNASSY0.99560.7859818
MRPL44-ABCG1chr2224824719chr2143645781717HLA-B73:01ERTALFIRNA0.99490.5091515
MRPL44-ABCG1chr2224824719chr2143645781717HLA-B15:05ALFIRNASSY0.92480.7173818
MRPL44-ABCG1chr2224824719chr2143645781717HLA-B15:11FIRNASSY0.99960.69761018
MRPL44-ABCG1chr2224824719chr2143645781717HLA-B15:08FIRNASSY0.99960.68391018
MRPL44-ABCG1chr2224824719chr2143645781717HLA-A30:01RTALFIRNA0.98760.8544615
MRPL44-ABCG1chr2224824719chr2143645781717HLA-C07:17LFIRNASSY0.47930.9184918
MRPL44-ABCG1chr2224824719chr2143645781717HLA-C14:03LFIRNASSY0.02390.8298918
MRPL44-ABCG1chr2224824719chr2143645781717HLA-C14:02LFIRNASSY0.02390.8298918
MRPL44-ABCG1chr2224824719chr2143645781717HLA-B15:33ALFIRNASSY0.99980.7816818
MRPL44-ABCG1chr2224824719chr2143645781717HLA-B15:27ALFIRNASSY0.99980.7642818
MRPL44-ABCG1chr2224824719chr2143645781717HLA-B15:125ALFIRNASSY0.99980.7816818
MRPL44-ABCG1chr2224824719chr2143645781717HLA-B15:50ALFIRNASSY0.99980.8364818
MRPL44-ABCG1chr2224824719chr2143645781717HLA-B15:34ALFIRNASSY0.99980.7816818
MRPL44-ABCG1chr2224824719chr2143645781717HLA-B15:135ALFIRNASSY0.99980.7877818
MRPL44-ABCG1chr2224824719chr2143645781717HLA-B15:35ALFIRNASSY0.99940.7641818
MRPL44-ABCG1chr2224824719chr2143645781717HLA-B15:12ALFIRNASSY0.99910.7794818
MRPL44-ABCG1chr2224824719chr2143645781717HLA-B15:39ALFIRNASSY0.99340.6575818
MRPL44-ABCG1chr2224824719chr2143645781717HLA-B15:20ALFIRNASSY0.93180.8013818

Top

Potential FusionNeoAntigen Information of MRPL44-ABCG1 in HLA II

check button Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.
MRPL44-ABCG1_224824719_43645781.msa

check button Potential FusionNeoAntigen Information
* We used NetMHCIIpan v4.1 (%rank<0.5).
Fusion geneHchrHbpTgeneTchrTbpHLA IIFusionNeoAntigen peptideNeoantigen start (at BP 13)Neoantigen end (at BP 13)
MRPL44-ABCG1chr2224824719chr2143645781717DRB3-0202RTALFIRNASSYSAE621
MRPL44-ABCG1chr2224824719chr2143645781717DRB3-0202TALFIRNASSYSAEM722
MRPL44-ABCG1chr2224824719chr2143645781717DRB3-0202ERTALFIRNASSYSA520
MRPL44-ABCG1chr2224824719chr2143645781717DRB3-0205RTALFIRNASSYSAE621
MRPL44-ABCG1chr2224824719chr2143645781717DRB3-0205TALFIRNASSYSAEM722
MRPL44-ABCG1chr2224824719chr2143645781717DRB3-0205ERTALFIRNASSYSA520
MRPL44-ABCG1chr2224824719chr2143645781717DRB3-0205ALFIRNASSYSAEMT823
MRPL44-ABCG1chr2224824719chr2143645781717DRB3-0210RTALFIRNASSYSAE621
MRPL44-ABCG1chr2224824719chr2143645781717DRB3-0210TALFIRNASSYSAEM722
MRPL44-ABCG1chr2224824719chr2143645781717DRB3-0210ERTALFIRNASSYSA520
MRPL44-ABCG1chr2224824719chr2143645781717DRB3-0211RTALFIRNASSYSAE621
MRPL44-ABCG1chr2224824719chr2143645781717DRB3-0211TALFIRNASSYSAEM722
MRPL44-ABCG1chr2224824719chr2143645781717DRB3-0211ERTALFIRNASSYSA520
MRPL44-ABCG1chr2224824719chr2143645781717DRB3-0212RTALFIRNASSYSAE621
MRPL44-ABCG1chr2224824719chr2143645781717DRB3-0212TALFIRNASSYSAEM722
MRPL44-ABCG1chr2224824719chr2143645781717DRB3-0212ERTALFIRNASSYSA520
MRPL44-ABCG1chr2224824719chr2143645781717DRB3-0213RTALFIRNASSYSAE621
MRPL44-ABCG1chr2224824719chr2143645781717DRB3-0213TALFIRNASSYSAEM722
MRPL44-ABCG1chr2224824719chr2143645781717DRB3-0214RTALFIRNASSYSAE621
MRPL44-ABCG1chr2224824719chr2143645781717DRB3-0214TALFIRNASSYSAEM722
MRPL44-ABCG1chr2224824719chr2143645781717DRB3-0215RTALFIRNASSYSAE621
MRPL44-ABCG1chr2224824719chr2143645781717DRB3-0215TALFIRNASSYSAEM722
MRPL44-ABCG1chr2224824719chr2143645781717DRB3-0216RTALFIRNASSYSAE621
MRPL44-ABCG1chr2224824719chr2143645781717DRB3-0216TALFIRNASSYSAEM722
MRPL44-ABCG1chr2224824719chr2143645781717DRB3-0217RTALFIRNASSYSAE621
MRPL44-ABCG1chr2224824719chr2143645781717DRB3-0217TALFIRNASSYSAEM722
MRPL44-ABCG1chr2224824719chr2143645781717DRB3-0217ERTALFIRNASSYSA520
MRPL44-ABCG1chr2224824719chr2143645781717DRB3-0218RTALFIRNASSYSAE621
MRPL44-ABCG1chr2224824719chr2143645781717DRB3-0218TALFIRNASSYSAEM722
MRPL44-ABCG1chr2224824719chr2143645781717DRB3-0218ERTALFIRNASSYSA520
MRPL44-ABCG1chr2224824719chr2143645781717DRB3-0219RTALFIRNASSYSAE621
MRPL44-ABCG1chr2224824719chr2143645781717DRB3-0219TALFIRNASSYSAEM722
MRPL44-ABCG1chr2224824719chr2143645781717DRB3-0220RTALFIRNASSYSAE621
MRPL44-ABCG1chr2224824719chr2143645781717DRB3-0220TALFIRNASSYSAEM722
MRPL44-ABCG1chr2224824719chr2143645781717DRB3-0220ERTALFIRNASSYSA520
MRPL44-ABCG1chr2224824719chr2143645781717DRB3-0222RTALFIRNASSYSAE621
MRPL44-ABCG1chr2224824719chr2143645781717DRB3-0222TALFIRNASSYSAEM722
MRPL44-ABCG1chr2224824719chr2143645781717DRB3-0223RTALFIRNASSYSAE621
MRPL44-ABCG1chr2224824719chr2143645781717DRB3-0223TALFIRNASSYSAEM722
MRPL44-ABCG1chr2224824719chr2143645781717DRB3-0223ERTALFIRNASSYSA520
MRPL44-ABCG1chr2224824719chr2143645781717DRB3-0225RTALFIRNASSYSAE621
MRPL44-ABCG1chr2224824719chr2143645781717DRB3-0225TALFIRNASSYSAEM722
MRPL44-ABCG1chr2224824719chr2143645781717DRB3-0225ERTALFIRNASSYSA520

Top

Fusion breakpoint peptide structures of MRPL44-ABCG1

check button3D structures of the fusion breakpoint peptide of 14AA sequence that have potential fusion neoantigens
* The minimum length of the amino acid sequence in RoseTTAFold is 14AA. Here, we predicted the 14AA fusion protein breakpoint sequence not the fusion neoantigen peptide, which is shorter than 14 AA.
File nameBPseqHgeneTgeneHchrHbpTchrTbpAAlen
8262RTALFIRNASSYSAMRPL44ABCG1chr2224824719chr2143645781717

Top

Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D of MRPL44-ABCG1

check buttonVirtual screening between 25 HLAs (from PDB) and FusionNeoAntigens
* We used Glide to predict the interaction between HLAs and neoantigens.
HLA allelePDB IDFile nameBPseqDocking scoreGlide score
HLA-B14:023BVN8262RTALFIRNASSYSA-6.00367-7.03897
HLA-B14:023BVN8262RTALFIRNASSYSA-5.39279-5.50619
HLA-B52:013W398262RTALFIRNASSYSA-6.37513-6.48853
HLA-B52:013W398262RTALFIRNASSYSA-5.71942-6.75472
HLA-A11:014UQ28262RTALFIRNASSYSA-11.5708-11.6842
HLA-A11:014UQ28262RTALFIRNASSYSA-8.11091-9.14621
HLA-A24:025HGA8262RTALFIRNASSYSA-6.75661-6.87001
HLA-A24:025HGA8262RTALFIRNASSYSA-5.30147-6.33677
HLA-B27:056PYJ8262RTALFIRNASSYSA-4.27108-5.30638
HLA-B44:053DX88262RTALFIRNASSYSA-6.47731-6.59071
HLA-B44:053DX88262RTALFIRNASSYSA-3.23433-4.26963

Top

Vaccine Design for the FusionNeoAntigens of MRPL44-ABCG1

check button mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-Is.
Fusion geneHchrHbpTchrTbpStart in +/-13AAEnd in +/-13AAFusionNeoAntigen peptide sequenceFusionNeoAntigen RNA sequence
MRPL44-ABCG1chr2224824719chr21436457811018FIRNASSYTTCATCAGGAATGCCAGCAGTTAC
MRPL44-ABCG1chr2224824719chr21436457811020FIRNASSYSATTCATCAGGAATGCCAGCAGTTACTCTGCA
MRPL44-ABCG1chr2224824719chr21436457811120IRNASSYSAATCAGGAATGCCAGCAGTTACTCTGCA
MRPL44-ABCG1chr2224824719chr2143645781515ERTALFIRNAGAGAGGACTGCACTTTTCATCAGGAATGCC
MRPL44-ABCG1chr2224824719chr2143645781615RTALFIRNAAGGACTGCACTTTTCATCAGGAATGCC
MRPL44-ABCG1chr2224824719chr2143645781818ALFIRNASSYGCACTTTTCATCAGGAATGCCAGCAGTTAC
MRPL44-ABCG1chr2224824719chr2143645781918LFIRNASSYCTTTTCATCAGGAATGCCAGCAGTTAC

check button mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-IIs.
Fusion geneHchrHbpTchrTbpStart in +/-13AAEnd in +/-13AAFusionNeoAntigen peptideFusionNEoAntigen RNA sequence
MRPL44-ABCG1chr2224824719chr2143645781520ERTALFIRNASSYSAGAGAGGACTGCACTTTTCATCAGGAATGCCAGCAGTTACTCTGCA
MRPL44-ABCG1chr2224824719chr2143645781621RTALFIRNASSYSAEAGGACTGCACTTTTCATCAGGAATGCCAGCAGTTACTCTGCAGAG
MRPL44-ABCG1chr2224824719chr2143645781722TALFIRNASSYSAEMACTGCACTTTTCATCAGGAATGCCAGCAGTTACTCTGCAGAGATG
MRPL44-ABCG1chr2224824719chr2143645781823ALFIRNASSYSAEMTGCACTTTTCATCAGGAATGCCAGCAGTTACTCTGCAGAGATGACG

Top

Information of the samples that have these potential fusion neoantigens of MRPL44-ABCG1

check button These samples were reported as having these fusion breakpoints. For individual breakpoints, we checked the open reading frames considering multiple gene isoforms and chose the in-frame fusion genes only. Then, we made fusion protein sequences and predicted the fusion neoantigens. These fusion-positive samples may have these potential fusion neoantigens.
Cancer typeFusion geneHchrHbpHenstTchrTbpTenstSample
PRADMRPL44-ABCG1chr2224824719ENST00000258383chr2143645781ENST00000398457TCGA-WW-A8ZI-01A

Top

Potential target of CAR-T therapy development for MRPL44-ABCG1

check button Predicted 3D structure. We used RoseTTAFold.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, to provide the retention of the transmembrane domain, we only show the protein feature retention information of those transmembrane features


* Minus value of BPloci means that the break point is located before the CDS.
- In-frame and retained 'Transmembrane'.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneABCG1chr2:224824719chr21:43645781ENST00000343687015427_4450678.0TransmembraneHelical
TgeneABCG1chr2:224824719chr21:43645781ENST00000343687015457_4770678.0TransmembraneHelical
TgeneABCG1chr2:224824719chr21:43645781ENST00000343687015507_5250678.0TransmembraneHelical
TgeneABCG1chr2:224824719chr21:43645781ENST00000343687015534_5550678.0TransmembraneHelical
TgeneABCG1chr2:224824719chr21:43645781ENST00000343687015568_5860678.0TransmembraneHelical
TgeneABCG1chr2:224824719chr21:43645781ENST00000343687015650_6690678.0TransmembraneHelical
TgeneABCG1chr2:224824719chr21:43645781ENST00000347800015427_4450664.0TransmembraneHelical
TgeneABCG1chr2:224824719chr21:43645781ENST00000347800015457_4770664.0TransmembraneHelical
TgeneABCG1chr2:224824719chr21:43645781ENST00000347800015507_5250664.0TransmembraneHelical
TgeneABCG1chr2:224824719chr21:43645781ENST00000347800015534_5550664.0TransmembraneHelical
TgeneABCG1chr2:224824719chr21:43645781ENST00000347800015568_5860664.0TransmembraneHelical
TgeneABCG1chr2:224824719chr21:43645781ENST00000347800015650_6690664.0TransmembraneHelical
TgeneABCG1chr2:224824719chr21:43645781ENST00000361802015427_4450679.0TransmembraneHelical
TgeneABCG1chr2:224824719chr21:43645781ENST00000361802015457_4770679.0TransmembraneHelical
TgeneABCG1chr2:224824719chr21:43645781ENST00000361802015507_5250679.0TransmembraneHelical
TgeneABCG1chr2:224824719chr21:43645781ENST00000361802015534_5550679.0TransmembraneHelical
TgeneABCG1chr2:224824719chr21:43645781ENST00000361802015568_5860679.0TransmembraneHelical
TgeneABCG1chr2:224824719chr21:43645781ENST00000361802015650_6690679.0TransmembraneHelical
TgeneABCG1chr2:224824719chr21:43645781ENST00000398449015427_4450667.0TransmembraneHelical
TgeneABCG1chr2:224824719chr21:43645781ENST00000398449015457_4770667.0TransmembraneHelical
TgeneABCG1chr2:224824719chr21:43645781ENST00000398449015507_5250667.0TransmembraneHelical
TgeneABCG1chr2:224824719chr21:43645781ENST00000398449015534_5550667.0TransmembraneHelical
TgeneABCG1chr2:224824719chr21:43645781ENST00000398449015568_5860667.0TransmembraneHelical
TgeneABCG1chr2:224824719chr21:43645781ENST00000398449015650_6690667.0TransmembraneHelical
TgeneABCG1chr2:224824719chr21:43645781ENST00000398457116427_4450669.0TransmembraneHelical
TgeneABCG1chr2:224824719chr21:43645781ENST00000398457116457_4770669.0TransmembraneHelical
TgeneABCG1chr2:224824719chr21:43645781ENST00000398457116507_5250669.0TransmembraneHelical
TgeneABCG1chr2:224824719chr21:43645781ENST00000398457116534_5550669.0TransmembraneHelical
TgeneABCG1chr2:224824719chr21:43645781ENST00000398457116568_5860669.0TransmembraneHelical
TgeneABCG1chr2:224824719chr21:43645781ENST00000398457116650_6690669.0TransmembraneHelical

check button Subcellular localization prediction of the transmembrane domain retained fusion proteins
* We used DeepLoc 1.0. The order of the X-axis of the barplot is as follows: Entry_ID, Localization, Type, Nucleus, Cytoplasm, Extracellular, Mitochondrion, Cell_membrane, Endoplasmic_reticulum, Plastid, Golgi.apparatus, Lysosome.Vacuole, Peroxisome. Y-axis is the output score of DeepLoc. Clicking the image will open a new tab with a large image.
HgeneHchrHbpHenstTgeneTchrTbpTenstDeepLoc result

Top

Related Drugs to MRPL44-ABCG1

check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

Top

Related Diseases to MRPL44-ABCG1

check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource