FusionNeoAntigen Logo

Home

Download

Statistics

Examples

Help

Contact

Terms of Use
Center for Computational Systems Medicine
leaf

Fusion Gene and Fusion Protein Summary

leaf

Fusion Amino Acid Sequences (multiple BPs and multiple gene isoforms)

leaf

Fusion Protein Breakpoint Sequences - (for the Screening of the FusionNeoAntigens)

leaf

Potential FusionNeoAntigens in HLA I - (netMHCpan v4.1 + deepHLApan v1.1)

leaf

Potential FusionNeoAntigens in HLA II - (netMHCIIpan v4.1)

leaf

Fusion Breakpoint 14 AA Peptide Structure - (RoseTTAFold)

leaf

Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D - (Glide)

leaf

Vaccine Design for the FusionNeoAntigens (RNA/protein sequences)

leaf

Potential target of CAR-T therapy development

leaf

Information on the samples that have these potential fusion neoantigens

leaf

Fusion Protein Targeting Drugs - (Manual Curation)

leaf

Fusion Protein Related diseases - (Manual Curation)

Fusion Protein:MXI1-HIF1A

Fusion Gene and Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: MXI1-HIF1A
FusionPDB ID: 56137
FusionGDB2.0 ID: 56137
HgeneTgene
Gene symbol

MXI1

HIF1A

Gene ID

4601

3091

Gene nameMAX interactor 1, dimerization proteinhypoxia inducible factor 1 subunit alpha
SynonymsMAD2|MXD2|MXI|bHLHc11HIF-1-alpha|HIF-1A|HIF-1alpha|HIF1|HIF1-ALPHA|MOP1|PASD8|bHLHe78
Cytomap

10q25.2

14q23.2

Type of geneprotein-codingprotein-coding
Descriptionmax-interacting protein 1MAX dimerization protein 2Max-related transcription factorclass C basic helix-loop-helix protein 11hypoxia-inducible factor 1-alphaARNT interacting proteinPAS domain-containing protein 8basic-helix-loop-helix-PAS protein MOP1class E basic helix-loop-helix protein 78hypoxia inducible factor 1 alpha subunithypoxia inducible factor 1, alpha subunit
Modification date2020031320200329
UniProtAcc

P50539

Main function of 5'-partner protein: FUNCTION: Transcriptional repressor. MXI1 binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3'. MXI1 thus antagonizes MYC transcriptional activity by competing for MAX.

Q9NWT6

Main function of 5'-partner protein: FUNCTION: Hydroxylates HIF-1 alpha at 'Asn-803' in the C-terminal transactivation domain (CAD). Functions as an oxygen sensor and, under normoxic conditions, the hydroxylation prevents interaction of HIF-1 with transcriptional coactivators including Cbp/p300-interacting transactivator. Involved in transcriptional repression through interaction with HIF1A, VHL and histone deacetylases. Hydroxylates specific Asn residues within ankyrin repeat domains (ARD) of NFKB1, NFKBIA, NOTCH1, ASB4, PPP1R12A and several other ARD-containing proteins. Also hydroxylates Asp and His residues within ARDs of ANK1 and TNKS2, respectively. Negatively regulates NOTCH1 activity, accelerating myogenic differentiation. Positively regulates ASB4 activity, promoting vascular differentiation. {ECO:0000269|PubMed:12042299, ECO:0000269|PubMed:12080085, ECO:0000269|PubMed:17003112, ECO:0000269|PubMed:17573339, ECO:0000269|PubMed:18299578, ECO:0000269|PubMed:19245366, ECO:0000269|PubMed:21177872, ECO:0000269|PubMed:21251231}.
Ensembl transtripts involved in fusion geneENST idsENST00000485566, ENST00000239007, 
ENST00000332674, ENST00000361248, 
ENST00000369612, ENST00000393134, 
ENST00000323441, ENST00000337138, 
ENST00000394997, ENST00000539097, 
ENST00000557538, ENST00000557206, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score8 X 8 X 4=2567 X 7 X 3=147
# samples 87
** MAII scorelog2(8/256*10)=-1.67807190511264
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/147*10)=-1.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Fusion gene context

PubMed: MXI1 [Title/Abstract] AND HIF1A [Title/Abstract] AND fusion [Title/Abstract]

Fusion neoantigen context

PubMed: MXI1 [Title/Abstract] AND HIF1A [Title/Abstract] AND neoantigen [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)MXI1(112039052)-HIF1A(62207754), # samples:1
Anticipated loss of major functional domain due to fusion event.MXI1-HIF1A seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
MXI1-HIF1A seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
MXI1-HIF1A seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
MXI1-HIF1A seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMXI1

GO:0000122

negative regulation of transcription by RNA polymerase II

11875718

TgeneHIF1A

GO:0001666

response to hypoxia

8756616|9887100|11782478|15261140|18419598

TgeneHIF1A

GO:0006355

regulation of transcription, DNA-templated

11782478|15261140

TgeneHIF1A

GO:0010468

regulation of gene expression

18419598

TgeneHIF1A

GO:0010573

vascular endothelial growth factor production

12958148

TgeneHIF1A

GO:0010575

positive regulation of vascular endothelial growth factor production

8756616

TgeneHIF1A

GO:0010628

positive regulation of gene expression

15459207|24244340

TgeneHIF1A

GO:0032364

oxygen homeostasis

16956324

TgeneHIF1A

GO:0043619

regulation of transcription from RNA polymerase II promoter in response to oxidative stress

8089148|8387214

TgeneHIF1A

GO:0045893

positive regulation of transcription, DNA-templated

8089148|9887100|25043030

TgeneHIF1A

GO:0045944

positive regulation of transcription by RNA polymerase II

11573933

TgeneHIF1A

GO:0046886

positive regulation of hormone biosynthetic process

1448077

TgeneHIF1A

GO:0061419

positive regulation of transcription from RNA polymerase II promoter in response to hypoxia

22735262

TgeneHIF1A

GO:0071456

cellular response to hypoxia

11573933|19528298|20889502

TgeneHIF1A

GO:1902895

positive regulation of pri-miRNA transcription by RNA polymerase II

19782034

TgeneHIF1A

GO:1903377

negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway

24899725



check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:112039052/chr14:62207754)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonRetention analysis results of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features, are available here.

check buttonFusion gene breakpoints across MXI1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across HIF1A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


Top

Fusion Amino Acid Sequences


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000332674MXI1chr10112039052+ENST00000394997HIF1Achr1462207754+24697562041295363
ENST00000332674MXI1chr10112039052+ENST00000337138HIF1Achr1462207754+24697562041295363
ENST00000332674MXI1chr10112039052+ENST00000323441HIF1Achr1462207754+23427562041022272
ENST00000332674MXI1chr10112039052+ENST00000557538HIF1Achr1462207754+19827562041295363
ENST00000332674MXI1chr10112039052+ENST00000539097HIF1Achr1462207754+19827562041295363
ENST00000361248MXI1chr10112039052+ENST00000394997HIF1Achr1462207754+2046333120872250
ENST00000361248MXI1chr10112039052+ENST00000337138HIF1Achr1462207754+2046333120872250
ENST00000361248MXI1chr10112039052+ENST00000323441HIF1Achr1462207754+1919333120599159
ENST00000361248MXI1chr10112039052+ENST00000557538HIF1Achr1462207754+1559333120872250
ENST00000361248MXI1chr10112039052+ENST00000539097HIF1Achr1462207754+1559333120872250
ENST00000239007MXI1chr10112039052+ENST00000394997HIF1Achr1462207754+22825691521108318
ENST00000239007MXI1chr10112039052+ENST00000337138HIF1Achr1462207754+22825691521108318
ENST00000239007MXI1chr10112039052+ENST00000323441HIF1Achr1462207754+2155569152835227
ENST00000239007MXI1chr10112039052+ENST00000557538HIF1Achr1462207754+17955691521108318
ENST00000239007MXI1chr10112039052+ENST00000539097HIF1Achr1462207754+17955691521108318
ENST00000393134MXI1chr10112039052+ENST00000394997HIF1Achr1462207754+216144861987308
ENST00000393134MXI1chr10112039052+ENST00000337138HIF1Achr1462207754+216144861987308
ENST00000393134MXI1chr10112039052+ENST00000323441HIF1Achr1462207754+203444861714217
ENST00000393134MXI1chr10112039052+ENST00000557538HIF1Achr1462207754+167444861987308
ENST00000393134MXI1chr10112039052+ENST00000539097HIF1Achr1462207754+167444861987308
ENST00000369612MXI1chr10112039052+ENST00000394997HIF1Achr1462207754+21954822391021260
ENST00000369612MXI1chr10112039052+ENST00000337138HIF1Achr1462207754+21954822391021260
ENST00000369612MXI1chr10112039052+ENST00000323441HIF1Achr1462207754+2068482239748169
ENST00000369612MXI1chr10112039052+ENST00000557538HIF1Achr1462207754+17084822391021260
ENST00000369612MXI1chr10112039052+ENST00000539097HIF1Achr1462207754+17084822391021260

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000332674ENST00000394997MXI1chr10112039052+HIF1Achr1462207754+0.0045007150.9954993
ENST00000332674ENST00000337138MXI1chr10112039052+HIF1Achr1462207754+0.0045007150.9954993
ENST00000332674ENST00000323441MXI1chr10112039052+HIF1Achr1462207754+0.0137723140.9862277
ENST00000332674ENST00000557538MXI1chr10112039052+HIF1Achr1462207754+0.0119341470.98806584
ENST00000332674ENST00000539097MXI1chr10112039052+HIF1Achr1462207754+0.0119341470.98806584
ENST00000361248ENST00000394997MXI1chr10112039052+HIF1Achr1462207754+0.0183876860.9816124
ENST00000361248ENST00000337138MXI1chr10112039052+HIF1Achr1462207754+0.0183876860.9816124
ENST00000361248ENST00000323441MXI1chr10112039052+HIF1Achr1462207754+0.044107080.95589286
ENST00000361248ENST00000557538MXI1chr10112039052+HIF1Achr1462207754+0.0216704420.9783296
ENST00000361248ENST00000539097MXI1chr10112039052+HIF1Achr1462207754+0.0216704420.9783296
ENST00000239007ENST00000394997MXI1chr10112039052+HIF1Achr1462207754+0.0048824490.99511755
ENST00000239007ENST00000337138MXI1chr10112039052+HIF1Achr1462207754+0.0048824490.99511755
ENST00000239007ENST00000323441MXI1chr10112039052+HIF1Achr1462207754+0.0134806990.9865193
ENST00000239007ENST00000557538MXI1chr10112039052+HIF1Achr1462207754+0.0100197470.9899803
ENST00000239007ENST00000539097MXI1chr10112039052+HIF1Achr1462207754+0.0100197470.9899803
ENST00000393134ENST00000394997MXI1chr10112039052+HIF1Achr1462207754+0.003594960.996405
ENST00000393134ENST00000337138MXI1chr10112039052+HIF1Achr1462207754+0.003594960.996405
ENST00000393134ENST00000323441MXI1chr10112039052+HIF1Achr1462207754+0.018083910.98191607
ENST00000393134ENST00000557538MXI1chr10112039052+HIF1Achr1462207754+0.0066659840.993334
ENST00000393134ENST00000539097MXI1chr10112039052+HIF1Achr1462207754+0.0066659840.993334
ENST00000369612ENST00000394997MXI1chr10112039052+HIF1Achr1462207754+0.0419170040.95808303
ENST00000369612ENST00000337138MXI1chr10112039052+HIF1Achr1462207754+0.0419170040.95808303
ENST00000369612ENST00000323441MXI1chr10112039052+HIF1Achr1462207754+0.171481550.8285184
ENST00000369612ENST00000557538MXI1chr10112039052+HIF1Achr1462207754+0.0642644840.9357355
ENST00000369612ENST00000539097MXI1chr10112039052+HIF1Achr1462207754+0.0642644840.9357355

check button Predicted full-length fusion amino acid sequences. For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among all the predicted ones.

Get the fusion protein sequences from here.

Fusion protein sequence information is available in the fasta format.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

Top

Fusion Protein Breakpoint Sequences for MXI1-HIF1A

check button +/-13 AA sequence from the breakpoints of the fusion protein sequences.
HgeneHchrHbpTgeneTchrTbpLength(fusion protein)BP in fusion proteinPeptide
MXI1chr10112039052HIF1Achr146220775433371TLGLLNKAKAHIKHKETTSATSSPYR
MXI1chr10112039052HIF1Achr1462207754448129TLGLLNKAKAHIKHKETTSATSSPYR
MXI1chr10112039052HIF1Achr146220775448281TLGLLNKAKAHIKHKETTSATSSPYR
MXI1chr10112039052HIF1Achr1462207754569139TLGLLNKAKAHIKHKETTSATSSPYR
MXI1chr10112039052HIF1Achr1462207754756184TLGLLNKAKAHIKHKETTSATSSPYR

Top

Potential FusionNeoAntigen Information of MXI1-HIF1A in HLA I

check button Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.
MXI1-HIF1A_112039052_62207754.msa

check button Potential FusionNeoAntigen Information
* We used NetMHCpan v4.1 (%rank<0.5) and deepHLApan v1.1 (immunogenic score>0.5)
Fusion geneHchrHbpTgeneTchrTbpHLA IFusionNeoAntigen peptideBinding scoreImmunogenic scoreNeoantigen start (at BP 13)Neoantigen end (at BP 13)
MXI1-HIF1Achr10112039052chr1462207754569HLA-A30:08KAKAHIKHK0.99780.6239615
MXI1-HIF1Achr10112039052chr1462207754569HLA-B39:06AHIKHKETT0.94190.9311918
MXI1-HIF1Achr10112039052chr1462207754569HLA-B39:06IKHKETTSA0.94030.89081120
MXI1-HIF1Achr10112039052chr1462207754569HLA-B39:06KHKETTSAT0.76210.79321221
MXI1-HIF1Achr10112039052chr1462207754569HLA-B08:09HIKHKETTSA0.99030.79291020
MXI1-HIF1Achr10112039052chr1462207754569HLA-B39:06AHIKHKETTSA0.99490.942920
MXI1-HIF1Achr10112039052chr1462207754569HLA-B39:05AHIKHKETT0.74710.9334918
MXI1-HIF1Achr10112039052chr1462207754569HLA-A30:01KAKAHIKHK0.9980.8194615

Top

Potential FusionNeoAntigen Information of MXI1-HIF1A in HLA II

check button Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.
MXI1-HIF1A_112039052_62207754.msa

check button Potential FusionNeoAntigen Information
* We used NetMHCIIpan v4.1 (%rank<0.5).
Fusion geneHchrHbpTgeneTchrTbpHLA IIFusionNeoAntigen peptideNeoantigen start (at BP 13)Neoantigen end (at BP 13)
MXI1-HIF1Achr10112039052chr1462207754569DRB1-0437KAHIKHKETTSATSS823
MXI1-HIF1Achr10112039052chr1462207754569DRB1-0437AKAHIKHKETTSATS722
MXI1-HIF1Achr10112039052chr1462207754569DRB1-0437KAKAHIKHKETTSAT621
MXI1-HIF1Achr10112039052chr1462207754569DRB1-0437AHIKHKETTSATSSP924
MXI1-HIF1Achr10112039052chr1462207754569DRB1-0804KAHIKHKETTSATSS823
MXI1-HIF1Achr10112039052chr1462207754569DRB1-0804AKAHIKHKETTSATS722
MXI1-HIF1Achr10112039052chr1462207754569DRB1-1103TLGLLNKAKAHIKHK015
MXI1-HIF1Achr10112039052chr1462207754569DRB1-1141TLGLLNKAKAHIKHK015
MXI1-HIF1Achr10112039052chr1462207754569DRB1-1148TLGLLNKAKAHIKHK015
MXI1-HIF1Achr10112039052chr1462207754569DRB1-1155TLGLLNKAKAHIKHK015
MXI1-HIF1Achr10112039052chr1462207754569DRB1-1163TLGLLNKAKAHIKHK015
MXI1-HIF1Achr10112039052chr1462207754569DRB1-1176TLGLLNKAKAHIKHK015
MXI1-HIF1Achr10112039052chr1462207754569DRB1-1185TLGLLNKAKAHIKHK015
MXI1-HIF1Achr10112039052chr1462207754569DRB1-1308TLGLLNKAKAHIKHK015
MXI1-HIF1Achr10112039052chr1462207754569DRB1-1315TLGLLNKAKAHIKHK015
MXI1-HIF1Achr10112039052chr1462207754569DRB1-1319TLGLLNKAKAHIKHK015
MXI1-HIF1Achr10112039052chr1462207754569DRB1-1324TLGLLNKAKAHIKHK015
MXI1-HIF1Achr10112039052chr1462207754569DRB1-1343TLGLLNKAKAHIKHK015
MXI1-HIF1Achr10112039052chr1462207754569DRB1-1353TLGLLNKAKAHIKHK015
MXI1-HIF1Achr10112039052chr1462207754569DRB1-1354TLGLLNKAKAHIKHK015
MXI1-HIF1Achr10112039052chr1462207754569DRB1-1357TLGLLNKAKAHIKHK015
MXI1-HIF1Achr10112039052chr1462207754569DRB1-1370TLGLLNKAKAHIKHK015
MXI1-HIF1Achr10112039052chr1462207754569DRB1-1372TLGLLNKAKAHIKHK015
MXI1-HIF1Achr10112039052chr1462207754569DRB1-1375TLGLLNKAKAHIKHK015
MXI1-HIF1Achr10112039052chr1462207754569DRB1-1376TLGLLNKAKAHIKHK015
MXI1-HIF1Achr10112039052chr1462207754569DRB1-1384TLGLLNKAKAHIKHK015
MXI1-HIF1Achr10112039052chr1462207754569DRB1-1415KAHIKHKETTSATSS823
MXI1-HIF1Achr10112039052chr1462207754569DRB1-1415AKAHIKHKETTSATS722
MXI1-HIF1Achr10112039052chr1462207754569DRB1-1416TLGLLNKAKAHIKHK015
MXI1-HIF1Achr10112039052chr1462207754569DRB5-0101LGLLNKAKAHIKHKE116
MXI1-HIF1Achr10112039052chr1462207754569DRB5-0104LGLLNKAKAHIKHKE116
MXI1-HIF1Achr10112039052chr1462207754569DRB5-0105LGLLNKAKAHIKHKE116
MXI1-HIF1Achr10112039052chr1462207754569DRB5-0113LGLLNKAKAHIKHKE116
MXI1-HIF1Achr10112039052chr1462207754569DRB5-0114LGLLNKAKAHIKHKE116

Top

Fusion breakpoint peptide structures of MXI1-HIF1A

check button3D structures of the fusion breakpoint peptide of 14AA sequence that have potential fusion neoantigens
* The minimum length of the amino acid sequence in RoseTTAFold is 14AA. Here, we predicted the 14AA fusion protein breakpoint sequence not the fusion neoantigen peptide, which is shorter than 14 AA.
File nameBPseqHgeneTgeneHchrHbpTchrTbpAAlen
4103KAKAHIKHKETTSAMXI1HIF1Achr10112039052chr1462207754569

Top

Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D of MXI1-HIF1A

check buttonVirtual screening between 25 HLAs (from PDB) and FusionNeoAntigens
* We used Glide to predict the interaction between HLAs and neoantigens.
HLA allelePDB IDFile nameBPseqDocking scoreGlide score

Top

Vaccine Design for the FusionNeoAntigens of MXI1-HIF1A

check button mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-Is.
Fusion geneHchrHbpTchrTbpStart in +/-13AAEnd in +/-13AAFusionNeoAntigen peptide sequenceFusionNeoAntigen RNA sequence
MXI1-HIF1Achr10112039052chr14622077541020HIKHKETTSACACATCAAGCATAAAGAAACTACTAGTGCC
MXI1-HIF1Achr10112039052chr14622077541120IKHKETTSAATCAAGCATAAAGAAACTACTAGTGCC
MXI1-HIF1Achr10112039052chr14622077541221KHKETTSATAAGCATAAAGAAACTACTAGTGCCACA
MXI1-HIF1Achr10112039052chr1462207754615KAKAHIKHKAAAGCCAAAGCACACATCAAGCATAAA
MXI1-HIF1Achr10112039052chr1462207754918AHIKHKETTGCACACATCAAGCATAAAGAAACTACT
MXI1-HIF1Achr10112039052chr1462207754920AHIKHKETTSAGCACACATCAAGCATAAAGAAACTACTAGTGCC

check button mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-IIs.
Fusion geneHchrHbpTchrTbpStart in +/-13AAEnd in +/-13AAFusionNeoAntigen peptideFusionNEoAntigen RNA sequence
MXI1-HIF1Achr10112039052chr1462207754015TLGLLNKAKAHIKHKACACTTGGTTTGCTCAACAAAGCCAAAGCACACATCAAGCATAAA
MXI1-HIF1Achr10112039052chr1462207754116LGLLNKAKAHIKHKECTTGGTTTGCTCAACAAAGCCAAAGCACACATCAAGCATAAAGAA
MXI1-HIF1Achr10112039052chr1462207754621KAKAHIKHKETTSATAAAGCCAAAGCACACATCAAGCATAAAGAAACTACTAGTGCCACA
MXI1-HIF1Achr10112039052chr1462207754722AKAHIKHKETTSATSGCCAAAGCACACATCAAGCATAAAGAAACTACTAGTGCCACATCA
MXI1-HIF1Achr10112039052chr1462207754823KAHIKHKETTSATSSAAAGCACACATCAAGCATAAAGAAACTACTAGTGCCACATCATCA
MXI1-HIF1Achr10112039052chr1462207754924AHIKHKETTSATSSPGCACACATCAAGCATAAAGAAACTACTAGTGCCACATCATCACCA

Top

Information of the samples that have these potential fusion neoantigens of MXI1-HIF1A

check button These samples were reported as having these fusion breakpoints. For individual breakpoints, we checked the open reading frames considering multiple gene isoforms and chose the in-frame fusion genes only. Then, we made fusion protein sequences and predicted the fusion neoantigens. These fusion-positive samples may have these potential fusion neoantigens.
Cancer typeFusion geneHchrHbpHenstTchrTbpTenstSample
N/AMXI1-HIF1Achr10112039052ENST00000239007chr1462207754ENST00000323441BE767238

Top

Potential target of CAR-T therapy development for MXI1-HIF1A

check button Predicted 3D structure. We used RoseTTAFold.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, to provide the retention of the transmembrane domain, we only show the protein feature retention information of those transmembrane features


* Minus value of BPloci means that the break point is located before the CDS.
- In-frame and retained 'Transmembrane'.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

check button Subcellular localization prediction of the transmembrane domain retained fusion proteins
* We used DeepLoc 1.0. The order of the X-axis of the barplot is as follows: Entry_ID, Localization, Type, Nucleus, Cytoplasm, Extracellular, Mitochondrion, Cell_membrane, Endoplasmic_reticulum, Plastid, Golgi.apparatus, Lysosome.Vacuole, Peroxisome. Y-axis is the output score of DeepLoc. Clicking the image will open a new tab with a large image.
HgeneHchrHbpHenstTgeneTchrTbpTenstDeepLoc result

Top

Related Drugs to MXI1-HIF1A

check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

Top

Related Diseases to MXI1-HIF1A

check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource