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Center for Computational Systems Medicine
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Fusion Gene and Fusion Protein Summary

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Fusion Amino Acid Sequences (multiple BPs and multiple gene isoforms)

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Fusion Protein Breakpoint Sequences - (for the Screening of the FusionNeoAntigens)

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Potential FusionNeoAntigens in HLA I - (netMHCpan v4.1 + deepHLApan v1.1)

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Potential FusionNeoAntigens in HLA II - (netMHCIIpan v4.1)

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Fusion Breakpoint 14 AA Peptide Structure - (RoseTTAFold)

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Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D - (Glide)

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Vaccine Design for the FusionNeoAntigens (RNA/protein sequences)

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Potential target of CAR-T therapy development

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Information on the samples that have these potential fusion neoantigens

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Fusion Protein Targeting Drugs - (Manual Curation)

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Fusion Protein Related diseases - (Manual Curation)

Fusion Protein:MYH11-FGFR1

Fusion Gene and Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: MYH11-FGFR1
FusionPDB ID: 56290
FusionGDB2.0 ID: 56290
HgeneTgene
Gene symbol

MYH11

FGFR1

Gene ID

4629

2260

Gene namemyosin heavy chain 11fibroblast growth factor receptor 1
SynonymsAAT4|FAA4|SMHC|SMMHCBFGFR|CD331|CEK|ECCL|FGFBR|FGFR-1|FLG|FLT-2|FLT2|HBGFR|HH2|HRTFDS|KAL2|N-SAM|OGD|bFGF-R-1
Cytomap

16p13.11

8p11.23

Type of geneprotein-codingprotein-coding
Descriptionmyosin-11epididymis secretory sperm binding proteinmyosin heavy chain, smooth muscle isoformmyosin, heavy chain 11, smooth musclemyosin, heavy polypeptide 11, smooth musclefibroblast growth factor receptor 1FGFR1/PLAG1 fusionFMS-like tyrosine kinase 2basic fibroblast growth factor receptor 1fms-related tyrosine kinase 2heparin-binding growth factor receptorhydroxyaryl-protein kinaseproto-oncogene c-Fgr
Modification date2020032220200329
UniProtAcc

P35749

Main function of 5'-partner protein: FUNCTION: Muscle contraction.

Q9NVK5

Main function of 5'-partner protein: FUNCTION: May be involved in wound healing pathway. {ECO:0000250}.
Ensembl transtripts involved in fusion geneENST idsENST00000300036, ENST00000396324, 
ENST00000452625, ENST00000576790, 
ENST00000573908, 		ENST00000496629, 
ENST00000326324, ENST00000335922, 
ENST00000341462, ENST00000356207, 
ENST00000397091, ENST00000397103, 
ENST00000397108, ENST00000397113, 
ENST00000425967, ENST00000447712, 
ENST00000532791, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score31 X 31 X 8=768825 X 34 X 7=5950
# samples 3222
** MAII scorelog2(32/7688*10)=-4.58646452588639
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(22/5950*10)=-4.75731423955801
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Fusion gene context

PubMed: MYH11 [Title/Abstract] AND FGFR1 [Title/Abstract] AND fusion [Title/Abstract]

Fusion neoantigen context

PubMed: MYH11 [Title/Abstract] AND FGFR1 [Title/Abstract] AND neoantigen [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)MYH11(15847255)-FGFR1(38271471), # samples:1
Anticipated loss of major functional domain due to fusion event.MYH11-FGFR1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
MYH11-FGFR1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
MYH11-FGFR1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
MYH11-FGFR1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
MYH11-FGFR1 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
MYH11-FGFR1 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
MYH11-FGFR1 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
MYH11-FGFR1 seems lost the major protein functional domain in Tgene partner, which is a kinase due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneFGFR1

GO:0008284

positive regulation of cell proliferation

8663044

TgeneFGFR1

GO:0008543

fibroblast growth factor receptor signaling pathway

8663044

TgeneFGFR1

GO:0010863

positive regulation of phospholipase C activity

18480409

TgeneFGFR1

GO:0018108

peptidyl-tyrosine phosphorylation

8622701|18480409

TgeneFGFR1

GO:0043406

positive regulation of MAP kinase activity

8622701|18480409

TgeneFGFR1

GO:0046777

protein autophosphorylation

8622701

TgeneFGFR1

GO:2000546

positive regulation of endothelial cell chemotaxis to fibroblast growth factor

21885851



check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr16:15847255/chr8:38271471)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonRetention analysis results of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features, are available here.

check buttonFusion gene breakpoints across MYH11 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across FGFR1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Amino Acid Sequences


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000396324MYH11chr1615847255-ENST00000425967FGFR1chr838271471-46761973612076671
ENST00000396324MYH11chr1615847255-ENST00000397091FGFR1chr838271471-46761973612076671
ENST00000396324MYH11chr1615847255-ENST00000447712FGFR1chr838271471-46751973612076671
ENST00000396324MYH11chr1615847255-ENST00000341462FGFR1chr838271471-46751973612076671
ENST00000396324MYH11chr1615847255-ENST00000532791FGFR1chr838271471-45831973612076671
ENST00000396324MYH11chr1615847255-ENST00000397113FGFR1chr838271471-30861973612076671
ENST00000396324MYH11chr1615847255-ENST00000356207FGFR1chr838271471-30841973612076671
ENST00000396324MYH11chr1615847255-ENST00000335922FGFR1chr838271471-30831973612076671
ENST00000396324MYH11chr1615847255-ENST00000326324FGFR1chr838271471-30821973612076671
ENST00000396324MYH11chr1615847255-ENST00000397103FGFR1chr838271471-28801973612076671
ENST00000396324MYH11chr1615847255-ENST00000397108FGFR1chr838271471-22921973612076671
ENST00000300036MYH11chr1615847255-ENST00000425967FGFR1chr838271471-46771974832077664
ENST00000300036MYH11chr1615847255-ENST00000397091FGFR1chr838271471-46771974832077664
ENST00000300036MYH11chr1615847255-ENST00000447712FGFR1chr838271471-46761974832077664
ENST00000300036MYH11chr1615847255-ENST00000341462FGFR1chr838271471-46761974832077664
ENST00000300036MYH11chr1615847255-ENST00000532791FGFR1chr838271471-45841974832077664
ENST00000300036MYH11chr1615847255-ENST00000397113FGFR1chr838271471-30871974832077664
ENST00000300036MYH11chr1615847255-ENST00000356207FGFR1chr838271471-30851974832077664
ENST00000300036MYH11chr1615847255-ENST00000335922FGFR1chr838271471-30841974832077664
ENST00000300036MYH11chr1615847255-ENST00000326324FGFR1chr838271471-30831974832077664
ENST00000300036MYH11chr1615847255-ENST00000397103FGFR1chr838271471-28811974832077664
ENST00000300036MYH11chr1615847255-ENST00000397108FGFR1chr838271471-22931974832077664

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000396324ENST00000425967MYH11chr1615847255-FGFR1chr838271471-0.0018929290.9981071
ENST00000396324ENST00000397091MYH11chr1615847255-FGFR1chr838271471-0.0018929290.9981071
ENST00000396324ENST00000447712MYH11chr1615847255-FGFR1chr838271471-0.0018860080.998114
ENST00000396324ENST00000341462MYH11chr1615847255-FGFR1chr838271471-0.0018860080.998114
ENST00000396324ENST00000532791MYH11chr1615847255-FGFR1chr838271471-0.0022085650.9977914
ENST00000396324ENST00000397113MYH11chr1615847255-FGFR1chr838271471-0.0044963560.9955036
ENST00000396324ENST00000356207MYH11chr1615847255-FGFR1chr838271471-0.0045366590.9954633
ENST00000396324ENST00000335922MYH11chr1615847255-FGFR1chr838271471-0.0045012270.9954987
ENST00000396324ENST00000326324MYH11chr1615847255-FGFR1chr838271471-0.0044726080.9955273
ENST00000396324ENST00000397103MYH11chr1615847255-FGFR1chr838271471-0.0069082790.9930917
ENST00000396324ENST00000397108MYH11chr1615847255-FGFR1chr838271471-0.009134870.9908652
ENST00000300036ENST00000425967MYH11chr1615847255-FGFR1chr838271471-0.0023293630.9976706
ENST00000300036ENST00000397091MYH11chr1615847255-FGFR1chr838271471-0.0023293630.9976706
ENST00000300036ENST00000447712MYH11chr1615847255-FGFR1chr838271471-0.0023195470.9976804
ENST00000300036ENST00000341462MYH11chr1615847255-FGFR1chr838271471-0.0023195470.9976804
ENST00000300036ENST00000532791MYH11chr1615847255-FGFR1chr838271471-0.0026984380.9973016
ENST00000300036ENST00000397113MYH11chr1615847255-FGFR1chr838271471-0.0054841310.99451584
ENST00000300036ENST00000356207MYH11chr1615847255-FGFR1chr838271471-0.0055414970.99445856
ENST00000300036ENST00000335922MYH11chr1615847255-FGFR1chr838271471-0.0054925110.9945075
ENST00000300036ENST00000326324MYH11chr1615847255-FGFR1chr838271471-0.0054683910.99453163
ENST00000300036ENST00000397103MYH11chr1615847255-FGFR1chr838271471-0.0081693520.99183065
ENST00000300036ENST00000397108MYH11chr1615847255-FGFR1chr838271471-0.0106835520.98931646

check button Predicted full-length fusion amino acid sequences. For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among all the predicted ones.

Get the fusion protein sequences from here.

Fusion protein sequence information is available in the fasta format.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

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Fusion Protein Breakpoint Sequences for MYH11-FGFR1

check button +/-13 AA sequence from the breakpoints of the fusion protein sequences.
HgeneHchrHbpTgeneTchrTbpLength(fusion protein)BP in fusion proteinPeptide

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Potential FusionNeoAntigen Information of MYH11-FGFR1 in HLA I

check button Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.

check button Potential FusionNeoAntigen Information
* We used NetMHCpan v4.1 (%rank<0.5) and deepHLApan v1.1 (immunogenic score>0.5)
Fusion geneHchrHbpTgeneTchrTbpHLA IFusionNeoAntigen peptideBinding scoreImmunogenic scoreNeoantigen start (at BP 13)Neoantigen end (at BP 13)

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Potential FusionNeoAntigen Information of MYH11-FGFR1 in HLA II

check button Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.

check button Potential FusionNeoAntigen Information
* We used NetMHCIIpan v4.1 (%rank<0.5).
Fusion geneHchrHbpTgeneTchrTbpHLA IIFusionNeoAntigen peptideNeoantigen start (at BP 13)Neoantigen end (at BP 13)

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Fusion breakpoint peptide structures of MYH11-FGFR1

check button3D structures of the fusion breakpoint peptide of 14AA sequence that have potential fusion neoantigens
* The minimum length of the amino acid sequence in RoseTTAFold is 14AA. Here, we predicted the 14AA fusion protein breakpoint sequence not the fusion neoantigen peptide, which is shorter than 14 AA.

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Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D of MYH11-FGFR1

check buttonVirtual screening between 25 HLAs (from PDB) and FusionNeoAntigens
* We used Glide to predict the interaction between HLAs and neoantigens.
HLA allelePDB IDFile nameBPseqDocking scoreGlide score

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Vaccine Design for the FusionNeoAntigens of MYH11-FGFR1

check button mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-Is.
Fusion geneHchrHbpTchrTbpStart in +/-13AAEnd in +/-13AAFusionNeoAntigen peptide sequenceFusionNeoAntigen RNA sequence

check button mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-IIs.
Fusion geneHchrHbpTchrTbpStart in +/-13AAEnd in +/-13AAFusionNeoAntigen peptideFusionNEoAntigen RNA sequence

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Information of the samples that have these potential fusion neoantigens of MYH11-FGFR1

check button These samples were reported as having these fusion breakpoints. For individual breakpoints, we checked the open reading frames considering multiple gene isoforms and chose the in-frame fusion genes only. Then, we made fusion protein sequences and predicted the fusion neoantigens. These fusion-positive samples may have these potential fusion neoantigens.
Cancer typeFusion geneHchrHbpHenstTchrTbpTenstSample

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Potential target of CAR-T therapy development for MYH11-FGFR1

check button Predicted 3D structure. We used RoseTTAFold.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, to provide the retention of the transmembrane domain, we only show the protein feature retention information of those transmembrane features


* Minus value of BPloci means that the break point is located before the CDS.
- In-frame and retained 'Transmembrane'.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneFGFR1chr16:15847255chr8:38271471ENST00000326324017377_3970732.0TransmembraneHelical
TgeneFGFR1chr16:15847255chr8:38271471ENST00000335922019377_3970813.0TransmembraneHelical
TgeneFGFR1chr16:15847255chr8:38271471ENST00000356207017377_3970734.0TransmembraneHelical
TgeneFGFR1chr16:15847255chr8:38271471ENST00000397091018377_3970821.0TransmembraneHelical
TgeneFGFR1chr16:15847255chr8:38271471ENST00000397108019377_3970821.0TransmembraneHelical
TgeneFGFR1chr16:15847255chr8:38271471ENST00000397113018377_3970821.0TransmembraneHelical
TgeneFGFR1chr16:15847255chr8:38271471ENST00000425967019377_3970854.0TransmembraneHelical
TgeneFGFR1chr16:15847255chr8:38271471ENST00000447712018377_3970823.0TransmembraneHelical
TgeneFGFR1chr16:15847255chr8:38271471ENST00000532791018377_3970821.0TransmembraneHelical

check button Subcellular localization prediction of the transmembrane domain retained fusion proteins
* We used DeepLoc 1.0. The order of the X-axis of the barplot is as follows: Entry_ID, Localization, Type, Nucleus, Cytoplasm, Extracellular, Mitochondrion, Cell_membrane, Endoplasmic_reticulum, Plastid, Golgi.apparatus, Lysosome.Vacuole, Peroxisome. Y-axis is the output score of DeepLoc. Clicking the image will open a new tab with a large image.
HgeneHchrHbpHenstTgeneTchrTbpTenstDeepLoc result

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Related Drugs to MYH11-FGFR1

check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to MYH11-FGFR1

check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneMYH11C4707243Familial thoracic aortic aneurysm and aortic dissection10CLINGEN;GENOMICS_ENGLAND
HgeneMYH11C0023467Leukemia, Myelocytic, Acute2CTD_human
HgeneMYH11C0023479Acute myelomonocytic leukemia2CTD_human;ORPHANET
HgeneMYH11C0026998Acute Myeloid Leukemia, M12CTD_human
HgeneMYH11C1851504Aortic aneurysm, familial thoracic 42CTD_human;GENOMICS_ENGLAND;UNIPROT
HgeneMYH11C1879321Acute Myeloid Leukemia (AML-M2)2CTD_human
HgeneMYH11C1608393Megacystis microcolon intestinal hypoperistalsis syndrome1GENOMICS_ENGLAND;ORPHANET
TgeneFGFR1C1563720Kallmann Syndrome 2 (disorder)18CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneFGFR1C1845146Holoprosencephaly, Ectrodactyly, and Bilateral Cleft Lip-Palate6GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneFGFR1C0011570Mental Depression5PSYGENET
TgeneFGFR1C0011581Depressive disorder5CTD_human;PSYGENET
TgeneFGFR1C0220658Pfeiffer Syndrome5GENOMICS_ENGLAND;UNIPROT
TgeneFGFR1C0432283Osteoglophonic dwarfism5CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneFGFR1C0041696Unipolar Depression4CTD_human;PSYGENET
TgeneFGFR1C0406612Encephalocraniocutaneous lipomatosis4CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneFGFR1C0005586Bipolar Disorder3PSYGENET
TgeneFGFR1C0795998JACKSON-WEISS SYNDROME3CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneFGFR1C1269683Major Depressive Disorder3PSYGENET
TgeneFGFR1C0006142Malignant neoplasm of breast2CGI;CTD_human
TgeneFGFR1C0007131Non-Small Cell Lung Carcinoma2CTD_human
TgeneFGFR1C0007137Squamous cell carcinoma2CTD_human
TgeneFGFR1C0027022Myeloproliferative disease2CTD_human
TgeneFGFR1C0162809Kallmann Syndrome2CTD_human;ORPHANET
TgeneFGFR1C0432122Interfrontal craniofaciosynostosis2GENOMICS_ENGLAND;UNIPROT
TgeneFGFR1C0678222Breast Carcinoma2CGI;CTD_human
TgeneFGFR1C1257931Mammary Neoplasms, Human2CTD_human
TgeneFGFR1C1458155Mammary Neoplasms2CTD_human
TgeneFGFR1C4704874Mammary Carcinoma, Human2CTD_human
TgeneFGFR1C0004114Astrocytoma1CTD_human
TgeneFGFR1C0008924Cleft upper lip1CTD_human
TgeneFGFR1C0008925Cleft Palate1CTD_human
TgeneFGFR1C0010278Craniosynostosis1CTD_human;GENOMICS_ENGLAND
TgeneFGFR1C0011573Endogenous depression1CTD_human
TgeneFGFR1C0017638Glioma1CTD_human
TgeneFGFR1C0018824Heart valve disease1CTD_human
TgeneFGFR1C0024121Lung Neoplasms1CTD_human
TgeneFGFR1C0025193Melancholia1CTD_human
TgeneFGFR1C0036341Schizophrenia1CTD_human
TgeneFGFR1C0085682Hypophosphatemia1GENOMICS_ENGLAND
TgeneFGFR1C0086133Depressive Syndrome1CTD_human
TgeneFGFR1C0149925Small cell carcinoma of lung1CTD_human
TgeneFGFR1C0205768Subependymal Giant Cell Astrocytoma1CTD_human
TgeneFGFR1C0206726gliosarcoma1ORPHANET
TgeneFGFR1C0242379Malignant neoplasm of lung1CTD_human
TgeneFGFR1C0259783mixed gliomas1CTD_human
TgeneFGFR1C0265535Trigonocephaly1CTD_human;ORPHANET
TgeneFGFR1C0280783Juvenile Pilocytic Astrocytoma1CTD_human
TgeneFGFR1C0280785Diffuse Astrocytoma1CTD_human
TgeneFGFR1C0282126Depression, Neurotic1CTD_human
TgeneFGFR1C0334579Anaplastic astrocytoma1CTD_human
TgeneFGFR1C0334580Protoplasmic astrocytoma1CTD_human
TgeneFGFR1C0334581Gemistocytic astrocytoma1CTD_human
TgeneFGFR1C0334582Fibrillary Astrocytoma1CTD_human
TgeneFGFR1C0334583Pilocytic Astrocytoma1CTD_human
TgeneFGFR1C0334588Giant Cell Glioblastoma1ORPHANET
TgeneFGFR1C0338070Childhood Cerebral Astrocytoma1CTD_human
TgeneFGFR1C0338503Septo-Optic Dysplasia1ORPHANET
TgeneFGFR1C0342384Idiopathic hypogonadotropic hypogonadism1GENOMICS_ENGLAND
TgeneFGFR1C0376634Craniofacial Abnormalities1CTD_human
TgeneFGFR1C0431362Lobar Holoprosencephaly1ORPHANET
TgeneFGFR1C0547065Mixed oligoastrocytoma1CTD_human
TgeneFGFR1C0555198Malignant Glioma1CTD_human
TgeneFGFR1C0750935Cerebral Astrocytoma1CTD_human
TgeneFGFR1C0750936Intracranial Astrocytoma1CTD_human
TgeneFGFR1C0751617Semilobar Holoprosencephaly1ORPHANET
TgeneFGFR1C1519086Pilomyxoid astrocytoma1ORPHANET
TgeneFGFR1C1704230Grade I Astrocytoma1CTD_human
TgeneFGFR1C1837218Cleft palate, isolated1CTD_human
TgeneFGFR1C1852406Cutis Gyrata Syndrome of Beare And Stevenson1GENOMICS_ENGLAND
TgeneFGFR1C2931196Craniofacial dysostosis type 11GENOMICS_ENGLAND
TgeneFGFR1C3150773CHROMOSOME 8p11 MYELOPROLIFERATIVE SYNDROME1ORPHANET