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Fusion Protein:NEDD4L-TBC1D17

Fusion Gene and Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: NEDD4L-TBC1D17
	FusionPDB ID: 58431
	FusionGDB2.0 ID: 58431
		Hgene	Tgene
	Gene symbol	NEDD4L	TBC1D17
	Gene ID	23327	79735
	Gene name	NEDD4 like E3 ubiquitin protein ligase	TBC1 domain family member 17
	Synonyms	NEDD4-2\|NEDD4.2\|PVNH7\|RSP5\|hNEDD4-2	-
	Cytomap	18q21.31	19q13.33
	Type of gene	protein-coding	protein-coding
	Description	E3 ubiquitin-protein ligase NEDD4-likeHECT-type E3 ubiquitin transferase NED4Lneural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligaseubiquitin-protein ligase Rsp5	TBC1 domain family member 17
	Modification date	20200329	20200313
	UniProtAcc	Q96PU5 Main function of 5'-partner protein: FUNCTION: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Inhibits TGF-beta signaling by triggering SMAD2 and TGFBR1 ubiquitination and proteasome-dependent degradation. Promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, SCN2A/Nav1.2, SCN3A/Nav1.3, SCN5A/Nav1.5, SCN9A/Nav1.7, SCN10A/Nav1.8, KCNA3/Kv1.3, KCNH2, EAAT1, KCNQ2/Kv7.2, KCNQ3/Kv7.3 or CLC5 (PubMed:26363003, PubMed:27445338). Promotes ubiquitination and degradation of SGK1 and TNK2. Ubiquitinates BRAT1 and this ubiquitination is enhanced in the presence of NDFIP1 (PubMed:25631046). Plays a role in dendrite formation by melanocytes (PubMed:23999003). Involved in the regulation of TOR signaling (PubMed:27694961). Ubiquitinates and regulates protein levels of NTRK1 once this one is activated by NGF (PubMed:27445338). {ECO:0000250\|UniProtKB:Q8CFI0, ECO:0000269\|PubMed:12911626, ECO:0000269\|PubMed:15040001, ECO:0000269\|PubMed:15217910, ECO:0000269\|PubMed:15489223, ECO:0000269\|PubMed:15496141, ECO:0000269\|PubMed:15576372, ECO:0000269\|PubMed:19144635, ECO:0000269\|PubMed:23999003, ECO:0000269\|PubMed:25631046, ECO:0000269\|PubMed:26363003, ECO:0000269\|PubMed:27445338, ECO:0000269\|PubMed:27694961}.	.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000256830, ENST00000356462, ENST00000357895, ENST00000382850, ENST00000400345, ENST00000586263, ENST00000256832, ENST00000431212, ENST00000435432, ENST00000456173, ENST00000456986, ENST00000588516, ENST00000589054,	ENST00000598789, ENST00000535102, ENST00000221543,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	28 X 18 X 11=5544	8 X 40 X 11=3520
	# samples	35	32
	** MAII score	log2(35/5544*10)=-3.98550043030488 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(32/3520*10)=-3.4594316186373 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Fusion gene context	PubMed: NEDD4L [Title/Abstract] AND TBC1D17 [Title/Abstract] AND fusion [Title/Abstract]
Fusion neoantigen context	PubMed: NEDD4L [Title/Abstract] AND TBC1D17 [Title/Abstract] AND neoantigen [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	NEDD4L(55919286)-TBC1D17(50381755), # samples:2
Anticipated loss of major functional domain due to fusion event.	NEDD4L-TBC1D17 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. NEDD4L-TBC1D17 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. NEDD4L-TBC1D17 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. NEDD4L-TBC1D17 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	NEDD4L	GO:0003254	regulation of membrane depolarization	15217910
Hgene	NEDD4L	GO:0006511	ubiquitin-dependent protein catabolic process	21463633
Hgene	NEDD4L	GO:0010038	response to metal ion	11244092
Hgene	NEDD4L	GO:0016567	protein ubiquitination	15217910\|25631046
Hgene	NEDD4L	GO:0034765	regulation of ion transmembrane transport	17289006
Hgene	NEDD4L	GO:0042391	regulation of membrane potential	17289006
Hgene	NEDD4L	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	21463633
Hgene	NEDD4L	GO:0060306	regulation of membrane repolarization	21463633
Hgene	NEDD4L	GO:0070936	protein K48-linked ubiquitination	21463633
Hgene	NEDD4L	GO:1901016	regulation of potassium ion transmembrane transporter activity	17289006
Hgene	NEDD4L	GO:1901017	negative regulation of potassium ion transmembrane transporter activity	21463633
Hgene	NEDD4L	GO:1901380	negative regulation of potassium ion transmembrane transport	21463633
Hgene	NEDD4L	GO:1902306	negative regulation of sodium ion transmembrane transport	15217910
Hgene	NEDD4L	GO:1903861	positive regulation of dendrite extension	23999003
Hgene	NEDD4L	GO:2000009	negative regulation of protein localization to cell surface	21463633
Hgene	NEDD4L	GO:2000650	negative regulation of sodium ion transmembrane transporter activity	15217910

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr18:55919286/chr19:50381755)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Retention analysis results of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features, are available here.

Fusion gene breakpoints across NEDD4L (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across TBC1D17 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Amino Acid Sequences

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000356462	NEDD4L	chr18	55919286	+	ENST00000221543	TBC1D17	chr19	50381755	+	2538	591	210	2417	735
ENST00000356462	NEDD4L	chr18	55919286	+	ENST00000535102	TBC1D17	chr19	50381755	+	2537	591	210	2417	735
ENST00000400345	NEDD4L	chr18	55919286	+	ENST00000221543	TBC1D17	chr19	50381755	+	2527	580	199	2406	735
ENST00000400345	NEDD4L	chr18	55919286	+	ENST00000535102	TBC1D17	chr19	50381755	+	2526	580	199	2406	735
ENST00000382850	NEDD4L	chr18	55919286	+	ENST00000221543	TBC1D17	chr19	50381755	+	2357	410	29	2236	735
ENST00000382850	NEDD4L	chr18	55919286	+	ENST00000535102	TBC1D17	chr19	50381755	+	2356	410	29	2236	735
ENST00000256830	NEDD4L	chr18	55919286	+	ENST00000221543	TBC1D17	chr19	50381755	+	2244	297	0	2123	707
ENST00000256830	NEDD4L	chr18	55919286	+	ENST00000535102	TBC1D17	chr19	50381755	+	2243	297	0	2123	707
ENST00000357895	NEDD4L	chr18	55919286	+	ENST00000221543	TBC1D17	chr19	50381755	+	2423	476	203	2302	699
ENST00000357895	NEDD4L	chr18	55919286	+	ENST00000535102	TBC1D17	chr19	50381755	+	2422	476	203	2302	699
ENST00000586263	NEDD4L	chr18	55919286	+	ENST00000221543	TBC1D17	chr19	50381755	+	2419	472	199	2298	699
ENST00000586263	NEDD4L	chr18	55919286	+	ENST00000535102	TBC1D17	chr19	50381755	+	2418	472	199	2298	699
ENST00000356462	NEDD4L	chr18	55919286	+	ENST00000221543	TBC1D17	chr19	50381400	+	2637	591	210	2516	768
ENST00000400345	NEDD4L	chr18	55919286	+	ENST00000221543	TBC1D17	chr19	50381400	+	2626	580	199	2505	768
ENST00000382850	NEDD4L	chr18	55919286	+	ENST00000221543	TBC1D17	chr19	50381400	+	2456	410	29	2335	768
ENST00000256830	NEDD4L	chr18	55919286	+	ENST00000221543	TBC1D17	chr19	50381400	+	2343	297	0	2222	740
ENST00000357895	NEDD4L	chr18	55919286	+	ENST00000221543	TBC1D17	chr19	50381400	+	2522	476	203	2401	732
ENST00000586263	NEDD4L	chr18	55919286	+	ENST00000221543	TBC1D17	chr19	50381400	+	2518	472	199	2397	732

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000356462	ENST00000221543	NEDD4L	chr18	55919286	+	TBC1D17	chr19	50381755	+	0.015783353	0.9842166
ENST00000356462	ENST00000535102	NEDD4L	chr18	55919286	+	TBC1D17	chr19	50381755	+	0.015680905	0.98431903
ENST00000400345	ENST00000221543	NEDD4L	chr18	55919286	+	TBC1D17	chr19	50381755	+	0.015211634	0.9847884
ENST00000400345	ENST00000535102	NEDD4L	chr18	55919286	+	TBC1D17	chr19	50381755	+	0.015118013	0.98488194
ENST00000382850	ENST00000221543	NEDD4L	chr18	55919286	+	TBC1D17	chr19	50381755	+	0.017170494	0.9828295
ENST00000382850	ENST00000535102	NEDD4L	chr18	55919286	+	TBC1D17	chr19	50381755	+	0.017078089	0.98292184
ENST00000256830	ENST00000221543	NEDD4L	chr18	55919286	+	TBC1D17	chr19	50381755	+	0.017092165	0.98290783
ENST00000256830	ENST00000535102	NEDD4L	chr18	55919286	+	TBC1D17	chr19	50381755	+	0.016979564	0.9830205
ENST00000357895	ENST00000221543	NEDD4L	chr18	55919286	+	TBC1D17	chr19	50381755	+	0.015285404	0.98471457
ENST00000357895	ENST00000535102	NEDD4L	chr18	55919286	+	TBC1D17	chr19	50381755	+	0.015223946	0.9847761
ENST00000586263	ENST00000221543	NEDD4L	chr18	55919286	+	TBC1D17	chr19	50381755	+	0.015185518	0.98481447
ENST00000586263	ENST00000535102	NEDD4L	chr18	55919286	+	TBC1D17	chr19	50381755	+	0.015124322	0.98487574
ENST00000356462	ENST00000221543	NEDD4L	chr18	55919286	+	TBC1D17	chr19	50381400	+	0.013149023	0.9868509
ENST00000400345	ENST00000221543	NEDD4L	chr18	55919286	+	TBC1D17	chr19	50381400	+	0.012669865	0.9873302
ENST00000382850	ENST00000221543	NEDD4L	chr18	55919286	+	TBC1D17	chr19	50381400	+	0.014326739	0.9856733
ENST00000256830	ENST00000221543	NEDD4L	chr18	55919286	+	TBC1D17	chr19	50381400	+	0.014155367	0.9858446
ENST00000357895	ENST00000221543	NEDD4L	chr18	55919286	+	TBC1D17	chr19	50381400	+	0.00631936	0.9936806
ENST00000586263	ENST00000221543	NEDD4L	chr18	55919286	+	TBC1D17	chr19	50381400	+	0.006295096	0.99370486

Predicted full-length fusion amino acid sequences. For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among all the predicted ones.

Get the fusion protein sequences from here.

Fusion protein sequence information is available in the fasta format.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

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Fusion Protein Breakpoint Sequences for NEDD4L-TBC1D17

+/-13 AA sequence from the breakpoints of the fusion protein sequences.

Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	Length(fusion protein)	BP in fusion protein	Peptide
NEDD4L	chr18	55919286	TBC1D17	chr19	50381400	297	99	HRLLFEVFDENRLVVFEKGGVYLHTS
NEDD4L	chr18	55919286	TBC1D17	chr19	50381400	410	127	HRLLFEVFDENRLVVFEKGGVYLHTS
NEDD4L	chr18	55919286	TBC1D17	chr19	50381400	472	91	HRLLFEVFDENRLVVFEKGGVYLHTS
NEDD4L	chr18	55919286	TBC1D17	chr19	50381400	476	91	HRLLFEVFDENRLVVFEKGGVYLHTS
NEDD4L	chr18	55919286	TBC1D17	chr19	50381400	580	127	HRLLFEVFDENRLVVFEKGGVYLHTS
NEDD4L	chr18	55919286	TBC1D17	chr19	50381400	591	127	HRLLFEVFDENRLVVFEKGGVYLHTS
NEDD4L	chr18	55919286	TBC1D17	chr19	50381755	297	99	HRLLFEVFDENRLDNDVLLHWAPVEE
NEDD4L	chr18	55919286	TBC1D17	chr19	50381755	410	127	HRLLFEVFDENRLDNDVLLHWAPVEE
NEDD4L	chr18	55919286	TBC1D17	chr19	50381755	472	91	HRLLFEVFDENRLDNDVLLHWAPVEE
NEDD4L	chr18	55919286	TBC1D17	chr19	50381755	476	91	HRLLFEVFDENRLDNDVLLHWAPVEE
NEDD4L	chr18	55919286	TBC1D17	chr19	50381755	580	127	HRLLFEVFDENRLDNDVLLHWAPVEE
NEDD4L	chr18	55919286	TBC1D17	chr19	50381755	591	127	HRLLFEVFDENRLDNDVLLHWAPVEE

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Potential FusionNeoAntigen Information of NEDD4L-TBC1D17 in HLA I

Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.

NEDD4L-TBC1D17_55919286_50381400.msa
NEDD4L-TBC1D17_55919286_50381755.msa

Potential FusionNeoAntigen Information
* We used NetMHCpan v4.1 (%rank<0.5) and deepHLApan v1.1 (immunogenic score>0.5)

Fusion gene	Hchr	Hbp	Tgene	Tchr	Tbp	HLA I	FusionNeoAntigen peptide	Binding score	Immunogenic score	Neoantigen start (at BP 13)	Neoantigen end (at BP 13)
NEDD4L-TBC1D17	chr18	55919286	chr19	50381400	297	HLA-B18:01	DENRLVVF	0.9997	0.7151	8	16
NEDD4L-TBC1D17	chr18	55919286	chr19	50381400	297	HLA-B08:09	VFDENRLVV	0.6761	0.659	6	15
NEDD4L-TBC1D17	chr18	55919286	chr19	50381400	297	HLA-B15:01	LVVFEKGGVY	0.9978	0.8205	12	22
NEDD4L-TBC1D17	chr18	55919286	chr19	50381400	297	HLA-B15:25	LVVFEKGGVY	0.9908	0.8665	12	22
NEDD4L-TBC1D17	chr18	55919286	chr19	50381400	297	HLA-B15:02	LVVFEKGGVY	0.9856	0.8886	12	22
NEDD4L-TBC1D17	chr18	55919286	chr19	50381400	297	HLA-B15:01	RLVVFEKGGVY	0.9988	0.8717	11	22
NEDD4L-TBC1D17	chr18	55919286	chr19	50381400	297	HLA-B15:25	RLVVFEKGGVY	0.9955	0.9373	11	22
NEDD4L-TBC1D17	chr18	55919286	chr19	50381400	297	HLA-C04:07	VFDENRLV	1	0.7002	6	14
NEDD4L-TBC1D17	chr18	55919286	chr19	50381400	297	HLA-C04:10	VFDENRLV	1	0.6705	6	14
NEDD4L-TBC1D17	chr18	55919286	chr19	50381400	297	HLA-C04:14	VFDENRLV	0.999	0.6696	6	14
NEDD4L-TBC1D17	chr18	55919286	chr19	50381400	297	HLA-C04:10	VFDENRLVV	0.9997	0.8591	6	15
NEDD4L-TBC1D17	chr18	55919286	chr19	50381400	297	HLA-C05:09	VFDENRLVV	0.9997	0.9749	6	15
NEDD4L-TBC1D17	chr18	55919286	chr19	50381400	297	HLA-C04:07	VFDENRLVV	0.9996	0.8785	6	15
NEDD4L-TBC1D17	chr18	55919286	chr19	50381400	297	HLA-C08:15	VFDENRLVV	0.9984	0.9769	6	15
NEDD4L-TBC1D17	chr18	55919286	chr19	50381400	297	HLA-C04:06	VFDENRLVV	0.9967	0.952	6	15
NEDD4L-TBC1D17	chr18	55919286	chr19	50381400	297	HLA-C08:13	VFDENRLVV	0.9836	0.9558	6	15
NEDD4L-TBC1D17	chr18	55919286	chr19	50381400	297	HLA-C08:04	VFDENRLVV	0.9836	0.9558	6	15
NEDD4L-TBC1D17	chr18	55919286	chr19	50381400	297	HLA-C04:14	VFDENRLVV	0.98	0.8974	6	15
NEDD4L-TBC1D17	chr18	55919286	chr19	50381400	297	HLA-C08:03	VFDENRLVV	0.9514	0.982	6	15
NEDD4L-TBC1D17	chr18	55919286	chr19	50381400	297	HLA-C07:10	VFDENRLVV	0.9425	0.9534	6	15
NEDD4L-TBC1D17	chr18	55919286	chr19	50381400	297	HLA-C07:29	VFDENRLVV	0.9418	0.9527	6	15
NEDD4L-TBC1D17	chr18	55919286	chr19	50381400	297	HLA-C07:80	VFDENRLVV	0.9404	0.9412	6	15
NEDD4L-TBC1D17	chr18	55919286	chr19	50381400	297	HLA-C07:67	VFDENRLVV	0.9404	0.9412	6	15
NEDD4L-TBC1D17	chr18	55919286	chr19	50381400	297	HLA-C07:13	VFDENRLVV	0.9347	0.9383	6	15
NEDD4L-TBC1D17	chr18	55919286	chr19	50381400	297	HLA-C07:19	VFDENRLVV	0.8829	0.718	6	15
NEDD4L-TBC1D17	chr18	55919286	chr19	50381400	297	HLA-C04:10	VFDENRLVVF	0.9999	0.6307	6	16
NEDD4L-TBC1D17	chr18	55919286	chr19	50381400	297	HLA-C04:07	VFDENRLVVF	0.9999	0.6668	6	16
NEDD4L-TBC1D17	chr18	55919286	chr19	50381400	297	HLA-C07:10	VFDENRLVVF	0.9994	0.9087	6	16
NEDD4L-TBC1D17	chr18	55919286	chr19	50381400	297	HLA-C07:80	VFDENRLVVF	0.9993	0.8881	6	16
NEDD4L-TBC1D17	chr18	55919286	chr19	50381400	297	HLA-C07:67	VFDENRLVVF	0.9993	0.8881	6	16
NEDD4L-TBC1D17	chr18	55919286	chr19	50381400	297	HLA-C04:14	VFDENRLVVF	0.9992	0.6829	6	16
NEDD4L-TBC1D17	chr18	55919286	chr19	50381400	297	HLA-C07:13	VFDENRLVVF	0.9985	0.8462	6	16
NEDD4L-TBC1D17	chr18	55919286	chr19	50381400	297	HLA-B15:07	LVVFEKGGVY	0.9936	0.5062	12	22
NEDD4L-TBC1D17	chr18	55919286	chr19	50381400	297	HLA-B15:07	RLVVFEKGGVY	0.9982	0.6512	11	22
NEDD4L-TBC1D17	chr18	55919286	chr19	50381400	297	HLA-B15:04	RLVVFEKGGVY	0.9966	0.8989	11	22
NEDD4L-TBC1D17	chr18	55919286	chr19	50381400	297	HLA-B15:05	RLVVFEKGGVY	0.972	0.8217	11	22
NEDD4L-TBC1D17	chr18	55919286	chr19	50381400	297	HLA-C18:01	VFDENRLV	1	0.7104	6	14
NEDD4L-TBC1D17	chr18	55919286	chr19	50381400	297	HLA-C04:01	VFDENRLV	1	0.7002	6	14
NEDD4L-TBC1D17	chr18	55919286	chr19	50381400	297	HLA-B18:04	DENRLVVF	0.9998	0.7485	8	16
NEDD4L-TBC1D17	chr18	55919286	chr19	50381400	297	HLA-B18:07	DENRLVVF	0.9998	0.6989	8	16
NEDD4L-TBC1D17	chr18	55919286	chr19	50381400	297	HLA-B18:05	DENRLVVF	0.9997	0.7151	8	16
NEDD4L-TBC1D17	chr18	55919286	chr19	50381400	297	HLA-B18:08	DENRLVVF	0.9997	0.6294	8	16
NEDD4L-TBC1D17	chr18	55919286	chr19	50381400	297	HLA-C04:04	VFDENRLV	0.9997	0.8363	6	14
NEDD4L-TBC1D17	chr18	55919286	chr19	50381400	297	HLA-B18:06	DENRLVVF	0.9996	0.7143	8	16
NEDD4L-TBC1D17	chr18	55919286	chr19	50381400	297	HLA-B18:03	DENRLVVF	0.9995	0.7146	8	16
NEDD4L-TBC1D17	chr18	55919286	chr19	50381400	297	HLA-B18:11	DENRLVVF	0.9945	0.6194	8	16
NEDD4L-TBC1D17	chr18	55919286	chr19	50381400	297	HLA-C04:03	VFDENRLVV	0.9997	0.9013	6	15
NEDD4L-TBC1D17	chr18	55919286	chr19	50381400	297	HLA-C05:01	VFDENRLVV	0.9997	0.9749	6	15
NEDD4L-TBC1D17	chr18	55919286	chr19	50381400	297	HLA-C01:03	VFDENRLVV	0.9996	0.9041	6	15
NEDD4L-TBC1D17	chr18	55919286	chr19	50381400	297	HLA-C04:01	VFDENRLVV	0.9996	0.8785	6	15
NEDD4L-TBC1D17	chr18	55919286	chr19	50381400	297	HLA-C18:01	VFDENRLVV	0.9995	0.8721	6	15
NEDD4L-TBC1D17	chr18	55919286	chr19	50381400	297	HLA-A68:02	EVFDENRLV	0.999	0.5116	5	14
NEDD4L-TBC1D17	chr18	55919286	chr19	50381400	297	HLA-C08:02	VFDENRLVV	0.9984	0.9769	6	15
NEDD4L-TBC1D17	chr18	55919286	chr19	50381400	297	HLA-A69:01	EVFDENRLV	0.9964	0.528	5	14
NEDD4L-TBC1D17	chr18	55919286	chr19	50381400	297	HLA-C04:04	VFDENRLVV	0.9943	0.9427	6	15
NEDD4L-TBC1D17	chr18	55919286	chr19	50381400	297	HLA-A25:01	EVFDENRLV	0.994	0.7745	5	14
NEDD4L-TBC1D17	chr18	55919286	chr19	50381400	297	HLA-C06:06	VFDENRLVV	0.9927	0.9696	6	15
NEDD4L-TBC1D17	chr18	55919286	chr19	50381400	297	HLA-C14:03	VFDENRLVV	0.9874	0.9411	6	15
NEDD4L-TBC1D17	chr18	55919286	chr19	50381400	297	HLA-C14:02	VFDENRLVV	0.9874	0.9411	6	15
NEDD4L-TBC1D17	chr18	55919286	chr19	50381400	297	HLA-C08:01	VFDENRLVV	0.9514	0.982	6	15
NEDD4L-TBC1D17	chr18	55919286	chr19	50381400	297	HLA-C07:04	VFDENRLVV	0.9405	0.9619	6	15
NEDD4L-TBC1D17	chr18	55919286	chr19	50381400	297	HLA-C07:02	VFDENRLVV	0.9404	0.9412	6	15
NEDD4L-TBC1D17	chr18	55919286	chr19	50381400	297	HLA-C07:17	VFDENRLVV	0.9401	0.9596	6	15
NEDD4L-TBC1D17	chr18	55919286	chr19	50381400	297	HLA-C03:67	VFDENRLVV	0.9254	0.9866	6	15
NEDD4L-TBC1D17	chr18	55919286	chr19	50381400	297	HLA-B08:12	VFDENRLVV	0.7188	0.7032	6	15
NEDD4L-TBC1D17	chr18	55919286	chr19	50381400	297	HLA-B07:13	VFDENRLVV	0.2139	0.7993	6	15
NEDD4L-TBC1D17	chr18	55919286	chr19	50381400	297	HLA-C04:01	VFDENRLVVF	0.9999	0.6668	6	16
NEDD4L-TBC1D17	chr18	55919286	chr19	50381400	297	HLA-C18:01	VFDENRLVVF	0.9999	0.6755	6	16
NEDD4L-TBC1D17	chr18	55919286	chr19	50381400	297	HLA-C04:03	VFDENRLVVF	0.9999	0.7177	6	16
NEDD4L-TBC1D17	chr18	55919286	chr19	50381400	297	HLA-C07:17	VFDENRLVVF	0.9995	0.9499	6	16
NEDD4L-TBC1D17	chr18	55919286	chr19	50381400	297	HLA-C07:02	VFDENRLVVF	0.9993	0.8881	6	16
NEDD4L-TBC1D17	chr18	55919286	chr19	50381400	297	HLA-C14:02	VFDENRLVVF	0.9987	0.9201	6	16
NEDD4L-TBC1D17	chr18	55919286	chr19	50381400	297	HLA-C14:03	VFDENRLVVF	0.9987	0.9201	6	16
NEDD4L-TBC1D17	chr18	55919286	chr19	50381400	297	HLA-C04:04	VFDENRLVVF	0.9985	0.736	6	16
NEDD4L-TBC1D17	chr18	55919286	chr19	50381400	297	HLA-B15:125	LVVFEKGGVY	0.9978	0.8205	12	22
NEDD4L-TBC1D17	chr18	55919286	chr19	50381400	297	HLA-B15:34	LVVFEKGGVY	0.9978	0.8205	12	22
NEDD4L-TBC1D17	chr18	55919286	chr19	50381400	297	HLA-B15:33	LVVFEKGGVY	0.9978	0.8205	12	22
NEDD4L-TBC1D17	chr18	55919286	chr19	50381400	297	HLA-B15:27	LVVFEKGGVY	0.9976	0.804	12	22
NEDD4L-TBC1D17	chr18	55919286	chr19	50381400	297	HLA-B15:135	LVVFEKGGVY	0.9973	0.8369	12	22
NEDD4L-TBC1D17	chr18	55919286	chr19	50381400	297	HLA-A68:02	EVFDENRLVV	0.9971	0.6511	5	15
NEDD4L-TBC1D17	chr18	55919286	chr19	50381400	297	HLA-B15:12	LVVFEKGGVY	0.996	0.8051	12	22
NEDD4L-TBC1D17	chr18	55919286	chr19	50381400	297	HLA-B15:50	LVVFEKGGVY	0.9947	0.9039	12	22
NEDD4L-TBC1D17	chr18	55919286	chr19	50381400	297	HLA-B15:35	LVVFEKGGVY	0.993	0.795	12	22
NEDD4L-TBC1D17	chr18	55919286	chr19	50381400	297	HLA-A69:01	EVFDENRLVV	0.9925	0.6429	5	15
NEDD4L-TBC1D17	chr18	55919286	chr19	50381400	297	HLA-B15:39	LVVFEKGGVY	0.9896	0.7589	12	22
NEDD4L-TBC1D17	chr18	55919286	chr19	50381400	297	HLA-A25:01	EVFDENRLVVF	0.9996	0.7312	5	16
NEDD4L-TBC1D17	chr18	55919286	chr19	50381400	297	HLA-B15:125	RLVVFEKGGVY	0.9988	0.8717	11	22
NEDD4L-TBC1D17	chr18	55919286	chr19	50381400	297	HLA-B15:34	RLVVFEKGGVY	0.9988	0.8717	11	22
NEDD4L-TBC1D17	chr18	55919286	chr19	50381400	297	HLA-B15:27	RLVVFEKGGVY	0.9988	0.8835	11	22
NEDD4L-TBC1D17	chr18	55919286	chr19	50381400	297	HLA-B15:33	RLVVFEKGGVY	0.9988	0.8717	11	22
NEDD4L-TBC1D17	chr18	55919286	chr19	50381400	297	HLA-B15:12	RLVVFEKGGVY	0.9988	0.8344	11	22
NEDD4L-TBC1D17	chr18	55919286	chr19	50381400	297	HLA-B15:135	RLVVFEKGGVY	0.9987	0.8886	11	22
NEDD4L-TBC1D17	chr18	55919286	chr19	50381400	297	HLA-B15:50	RLVVFEKGGVY	0.9985	0.9321	11	22
NEDD4L-TBC1D17	chr18	55919286	chr19	50381400	297	HLA-B15:35	RLVVFEKGGVY	0.9978	0.8616	11	22
NEDD4L-TBC1D17	chr18	55919286	chr19	50381400	297	HLA-B15:39	RLVVFEKGGVY	0.9955	0.8418	11	22
NEDD4L-TBC1D17	chr18	55919286	chr19	50381400	297	HLA-B15:20	RLVVFEKGGVY	0.9734	0.8848	11	22
NEDD4L-TBC1D17	chr18	55919286	chr19	50381400	297	HLA-B15:68	RLVVFEKGGVY	0.886	0.5182	11	22
NEDD4L-TBC1D17	chr18	55919286	chr19	50381755	297	HLA-B27:02	NRLDNDVLL	0.9991	0.5018	10	19
NEDD4L-TBC1D17	chr18	55919286	chr19	50381755	297	HLA-B39:01	NRLDNDVLL	0.9987	0.8182	10	19
NEDD4L-TBC1D17	chr18	55919286	chr19	50381755	297	HLA-B38:02	NRLDNDVLL	0.998	0.9055	10	19
NEDD4L-TBC1D17	chr18	55919286	chr19	50381755	297	HLA-B38:01	NRLDNDVLL	0.998	0.8806	10	19
NEDD4L-TBC1D17	chr18	55919286	chr19	50381755	297	HLA-B39:06	NRLDNDVLL	0.998	0.6701	10	19
NEDD4L-TBC1D17	chr18	55919286	chr19	50381755	297	HLA-B58:02	LDNDVLLHW	0.9931	0.9599	12	21
NEDD4L-TBC1D17	chr18	55919286	chr19	50381755	297	HLA-B58:01	LDNDVLLHW	0.9925	0.9691	12	21
NEDD4L-TBC1D17	chr18	55919286	chr19	50381755	297	HLA-B44:03	LDNDVLLHW	0.9821	0.9868	12	21
NEDD4L-TBC1D17	chr18	55919286	chr19	50381755	297	HLA-B44:02	LDNDVLLHW	0.9803	0.628	12	21
NEDD4L-TBC1D17	chr18	55919286	chr19	50381755	297	HLA-B15:37	NRLDNDVLL	0.7344	0.5629	10	19
NEDD4L-TBC1D17	chr18	55919286	chr19	50381755	297	HLA-B15:18	NRLDNDVLL	0.516	0.6257	10	19
NEDD4L-TBC1D17	chr18	55919286	chr19	50381755	297	HLA-B57:01	RLDNDVLLHW	0.9997	0.9917	11	21
NEDD4L-TBC1D17	chr18	55919286	chr19	50381755	297	HLA-B58:02	RLDNDVLLHW	0.9987	0.9753	11	21
NEDD4L-TBC1D17	chr18	55919286	chr19	50381755	297	HLA-A31:08	RLDNDVLLHW	0.9986	0.6383	11	21
NEDD4L-TBC1D17	chr18	55919286	chr19	50381755	297	HLA-B58:01	RLDNDVLLHW	0.9976	0.976	11	21
NEDD4L-TBC1D17	chr18	55919286	chr19	50381755	297	HLA-A32:13	RLDNDVLLHW	0.9974	0.9846	11	21
NEDD4L-TBC1D17	chr18	55919286	chr19	50381755	297	HLA-B57:03	RLDNDVLLHW	0.9925	0.9958	11	21
NEDD4L-TBC1D17	chr18	55919286	chr19	50381755	297	HLA-B44:02	RLDNDVLLHW	0.9251	0.7326	11	21
NEDD4L-TBC1D17	chr18	55919286	chr19	50381755	297	HLA-A24:14	RLDNDVLLHW	0.7152	0.6516	11	21
NEDD4L-TBC1D17	chr18	55919286	chr19	50381755	297	HLA-B38:01	ENRLDNDVLL	0.6458	0.8233	9	19
NEDD4L-TBC1D17	chr18	55919286	chr19	50381755	297	HLA-B38:02	ENRLDNDVLL	0.6427	0.8524	9	19
NEDD4L-TBC1D17	chr18	55919286	chr19	50381755	297	HLA-B13:01	RLDNDVLLHW	0.6076	0.9978	11	21
NEDD4L-TBC1D17	chr18	55919286	chr19	50381755	297	HLA-B27:02	NRLDNDVLLHW	1	0.7252	10	21
NEDD4L-TBC1D17	chr18	55919286	chr19	50381755	297	HLA-C05:09	RLDNDVLL	1	0.9223	11	19
NEDD4L-TBC1D17	chr18	55919286	chr19	50381755	297	HLA-C08:15	RLDNDVLL	0.9999	0.9558	11	19
NEDD4L-TBC1D17	chr18	55919286	chr19	50381755	297	HLA-B39:12	NRLDNDVL	0.999	0.7352	10	18
NEDD4L-TBC1D17	chr18	55919286	chr19	50381755	297	HLA-B39:05	NRLDNDVL	0.9983	0.7082	10	18
NEDD4L-TBC1D17	chr18	55919286	chr19	50381755	297	HLA-B39:12	NRLDNDVLL	0.9985	0.8314	10	19
NEDD4L-TBC1D17	chr18	55919286	chr19	50381755	297	HLA-C07:95	NRLDNDVLL	0.9977	0.5944	10	19
NEDD4L-TBC1D17	chr18	55919286	chr19	50381755	297	HLA-B39:05	NRLDNDVLL	0.9977	0.8014	10	19
NEDD4L-TBC1D17	chr18	55919286	chr19	50381755	297	HLA-C07:05	NRLDNDVLL	0.9976	0.9287	10	19
NEDD4L-TBC1D17	chr18	55919286	chr19	50381755	297	HLA-C07:13	NRLDNDVLL	0.9971	0.8331	10	19
NEDD4L-TBC1D17	chr18	55919286	chr19	50381755	297	HLA-C07:27	NRLDNDVLL	0.9967	0.9171	10	19
NEDD4L-TBC1D17	chr18	55919286	chr19	50381755	297	HLA-C07:29	NRLDNDVLL	0.9962	0.9243	10	19
NEDD4L-TBC1D17	chr18	55919286	chr19	50381755	297	HLA-B44:04	LDNDVLLHW	0.9955	0.6405	12	21
NEDD4L-TBC1D17	chr18	55919286	chr19	50381755	297	HLA-B44:08	LDNDVLLHW	0.9796	0.7024	12	21
NEDD4L-TBC1D17	chr18	55919286	chr19	50381755	297	HLA-C07:46	NRLDNDVLL	0.9104	0.7493	10	19
NEDD4L-TBC1D17	chr18	55919286	chr19	50381755	297	HLA-C07:67	NRLDNDVLL	0.9069	0.8827	10	19
NEDD4L-TBC1D17	chr18	55919286	chr19	50381755	297	HLA-C07:80	NRLDNDVLL	0.9069	0.8827	10	19
NEDD4L-TBC1D17	chr18	55919286	chr19	50381755	297	HLA-C07:10	NRLDNDVLL	0.8782	0.9147	10	19
NEDD4L-TBC1D17	chr18	55919286	chr19	50381755	297	HLA-C07:19	NRLDNDVLL	0.8648	0.547	10	19
NEDD4L-TBC1D17	chr18	55919286	chr19	50381755	297	HLA-B14:03	NRLDNDVLL	0.4995	0.6628	10	19
NEDD4L-TBC1D17	chr18	55919286	chr19	50381755	297	HLA-C12:16	NRLDNDVLL	0.0563	0.9422	10	19
NEDD4L-TBC1D17	chr18	55919286	chr19	50381755	297	HLA-B44:08	RLDNDVLLHW	0.9533	0.7731	11	21
NEDD4L-TBC1D17	chr18	55919286	chr19	50381755	297	HLA-B44:04	RLDNDVLLHW	0.9408	0.7302	11	21
NEDD4L-TBC1D17	chr18	55919286	chr19	50381755	297	HLA-C05:01	RLDNDVLL	1	0.9223	11	19
NEDD4L-TBC1D17	chr18	55919286	chr19	50381755	297	HLA-C04:03	RLDNDVLL	1	0.7713	11	19
NEDD4L-TBC1D17	chr18	55919286	chr19	50381755	297	HLA-C08:02	RLDNDVLL	0.9999	0.9558	11	19
NEDD4L-TBC1D17	chr18	55919286	chr19	50381755	297	HLA-B39:31	NRLDNDVL	0.9992	0.7267	10	18
NEDD4L-TBC1D17	chr18	55919286	chr19	50381755	297	HLA-B27:06	NRLDNDVLL	0.9993	0.5647	10	19
NEDD4L-TBC1D17	chr18	55919286	chr19	50381755	297	HLA-B27:09	NRLDNDVLL	0.9992	0.8311	10	19
NEDD4L-TBC1D17	chr18	55919286	chr19	50381755	297	HLA-B27:08	NRLDNDVLL	0.9991	0.6774	10	19
NEDD4L-TBC1D17	chr18	55919286	chr19	50381755	297	HLA-B39:31	NRLDNDVLL	0.9988	0.8216	10	19
NEDD4L-TBC1D17	chr18	55919286	chr19	50381755	297	HLA-B38:05	NRLDNDVLL	0.998	0.8806	10	19
NEDD4L-TBC1D17	chr18	55919286	chr19	50381755	297	HLA-C07:01	NRLDNDVLL	0.9978	0.5362	10	19
NEDD4L-TBC1D17	chr18	55919286	chr19	50381755	297	HLA-B44:13	LDNDVLLHW	0.9821	0.9868	12	21
NEDD4L-TBC1D17	chr18	55919286	chr19	50381755	297	HLA-B44:07	LDNDVLLHW	0.9821	0.9868	12	21
NEDD4L-TBC1D17	chr18	55919286	chr19	50381755	297	HLA-B44:26	LDNDVLLHW	0.9821	0.9868	12	21
NEDD4L-TBC1D17	chr18	55919286	chr19	50381755	297	HLA-C07:17	NRLDNDVLL	0.9812	0.9581	10	19
NEDD4L-TBC1D17	chr18	55919286	chr19	50381755	297	HLA-B44:22	LDNDVLLHW	0.9803	0.628	12	21
NEDD4L-TBC1D17	chr18	55919286	chr19	50381755	297	HLA-B44:21	LDNDVLLHW	0.978	0.5874	12	21
NEDD4L-TBC1D17	chr18	55919286	chr19	50381755	297	HLA-C06:08	NRLDNDVLL	0.9291	0.9659	10	19
NEDD4L-TBC1D17	chr18	55919286	chr19	50381755	297	HLA-C07:02	NRLDNDVLL	0.9069	0.8827	10	19
NEDD4L-TBC1D17	chr18	55919286	chr19	50381755	297	HLA-C07:04	NRLDNDVLL	0.8727	0.7423	10	19
NEDD4L-TBC1D17	chr18	55919286	chr19	50381755	297	HLA-C06:06	NRLDNDVLL	0.8274	0.9681	10	19
NEDD4L-TBC1D17	chr18	55919286	chr19	50381755	297	HLA-C07:22	NRLDNDVLL	0.8087	0.6272	10	19
NEDD4L-TBC1D17	chr18	55919286	chr19	50381755	297	HLA-B15:13	LDNDVLLHW	0.7957	0.826	12	21
NEDD4L-TBC1D17	chr18	55919286	chr19	50381755	297	HLA-B39:11	NRLDNDVLL	0.7489	0.6158	10	19
NEDD4L-TBC1D17	chr18	55919286	chr19	50381755	297	HLA-C06:02	NRLDNDVLL	0.0652	0.9864	10	19
NEDD4L-TBC1D17	chr18	55919286	chr19	50381755	297	HLA-C06:17	NRLDNDVLL	0.0652	0.9864	10	19
NEDD4L-TBC1D17	chr18	55919286	chr19	50381755	297	HLA-B57:10	RLDNDVLLHW	0.9997	0.9917	11	21
NEDD4L-TBC1D17	chr18	55919286	chr19	50381755	297	HLA-B57:04	RLDNDVLLHW	0.9989	0.8307	11	21
NEDD4L-TBC1D17	chr18	55919286	chr19	50381755	297	HLA-A32:01	RLDNDVLLHW	0.9983	0.9941	11	21
NEDD4L-TBC1D17	chr18	55919286	chr19	50381755	297	HLA-B58:06	RLDNDVLLHW	0.996	0.9558	11	21
NEDD4L-TBC1D17	chr18	55919286	chr19	50381755	297	HLA-B57:02	RLDNDVLLHW	0.9957	0.9869	11	21
NEDD4L-TBC1D17	chr18	55919286	chr19	50381755	297	HLA-B15:24	RLDNDVLLHW	0.9766	0.9903	11	21
NEDD4L-TBC1D17	chr18	55919286	chr19	50381755	297	HLA-B44:21	RLDNDVLLHW	0.9351	0.7118	11	21
NEDD4L-TBC1D17	chr18	55919286	chr19	50381755	297	HLA-B44:22	RLDNDVLLHW	0.9251	0.7326	11	21
NEDD4L-TBC1D17	chr18	55919286	chr19	50381755	297	HLA-B39:31	ENRLDNDVLL	0.7453	0.8013	9	19
NEDD4L-TBC1D17	chr18	55919286	chr19	50381755	297	HLA-B38:05	ENRLDNDVLL	0.6458	0.8233	9	19

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Potential FusionNeoAntigen Information of NEDD4L-TBC1D17 in HLA II

NEDD4L-TBC1D17_55919286_50381400.msa
NEDD4L-TBC1D17_55919286_50381755.msa

Potential FusionNeoAntigen Information
* We used NetMHCIIpan v4.1 (%rank<0.5).

Fusion gene	Hchr	Hbp	Tgene	Tchr	Tbp	HLA II	FusionNeoAntigen peptide	Neoantigen start (at BP 13)	Neoantigen end (at BP 13)
NEDD4L-TBC1D17	chr18	55919286	chr19	50381400	297	DRB1-1113	ENRLVVFEKGGVYLH	9	24
NEDD4L-TBC1D17	chr18	55919286	chr19	50381400	297	DRB1-1113	DENRLVVFEKGGVYL	8	23
NEDD4L-TBC1D17	chr18	55919286	chr19	50381400	297	DRB1-1113	FDENRLVVFEKGGVY	7	22
NEDD4L-TBC1D17	chr18	55919286	chr19	50381400	297	DRB1-1189	ENRLVVFEKGGVYLH	9	24
NEDD4L-TBC1D17	chr18	55919286	chr19	50381400	297	DRB1-1304	ENRLVVFEKGGVYLH	9	24
NEDD4L-TBC1D17	chr18	55919286	chr19	50381400	297	DRB1-1309	ENRLVVFEKGGVYLH	9	24
NEDD4L-TBC1D17	chr18	55919286	chr19	50381400	297	DRB1-1343	ENRLVVFEKGGVYLH	9	24
NEDD4L-TBC1D17	chr18	55919286	chr19	50381400	297	DRB1-1354	ENRLVVFEKGGVYLH	9	24
NEDD4L-TBC1D17	chr18	55919286	chr19	50381400	297	DRB1-1354	FDENRLVVFEKGGVY	7	22
NEDD4L-TBC1D17	chr18	55919286	chr19	50381400	297	DRB1-1354	DENRLVVFEKGGVYL	8	23
NEDD4L-TBC1D17	chr18	55919286	chr19	50381400	297	DRB1-1377	ENRLVVFEKGGVYLH	9	24
NEDD4L-TBC1D17	chr18	55919286	chr19	50381400	297	DRB1-1377	DENRLVVFEKGGVYL	8	23
NEDD4L-TBC1D17	chr18	55919286	chr19	50381400	297	DRB1-1377	FDENRLVVFEKGGVY	7	22
NEDD4L-TBC1D17	chr18	55919286	chr19	50381400	297	DRB1-1393	ENRLVVFEKGGVYLH	9	24
NEDD4L-TBC1D17	chr18	55919286	chr19	50381400	297	DRB1-1404	ENRLVVFEKGGVYLH	9	24
NEDD4L-TBC1D17	chr18	55919286	chr19	50381400	297	DRB1-1404	FDENRLVVFEKGGVY	7	22
NEDD4L-TBC1D17	chr18	55919286	chr19	50381400	297	DRB1-1404	DENRLVVFEKGGVYL	8	23
NEDD4L-TBC1D17	chr18	55919286	chr19	50381400	297	DRB1-1406	ENRLVVFEKGGVYLH	9	24
NEDD4L-TBC1D17	chr18	55919286	chr19	50381400	297	DRB1-1411	ENRLVVFEKGGVYLH	9	24
NEDD4L-TBC1D17	chr18	55919286	chr19	50381400	297	DRB1-1411	DENRLVVFEKGGVYL	8	23
NEDD4L-TBC1D17	chr18	55919286	chr19	50381400	297	DRB1-1416	ENRLVVFEKGGVYLH	9	24
NEDD4L-TBC1D17	chr18	55919286	chr19	50381400	297	DRB1-1416	DENRLVVFEKGGVYL	8	23
NEDD4L-TBC1D17	chr18	55919286	chr19	50381400	297	DRB1-1418	ENRLVVFEKGGVYLH	9	24
NEDD4L-TBC1D17	chr18	55919286	chr19	50381400	297	DRB1-1420	ENRLVVFEKGGVYLH	9	24
NEDD4L-TBC1D17	chr18	55919286	chr19	50381400	297	DRB1-1428	ENRLVVFEKGGVYLH	9	24
NEDD4L-TBC1D17	chr18	55919286	chr19	50381400	297	DRB1-1431	ENRLVVFEKGGVYLH	9	24
NEDD4L-TBC1D17	chr18	55919286	chr19	50381400	297	DRB1-1431	DENRLVVFEKGGVYL	8	23
NEDD4L-TBC1D17	chr18	55919286	chr19	50381400	297	DRB1-1431	FDENRLVVFEKGGVY	7	22
NEDD4L-TBC1D17	chr18	55919286	chr19	50381400	297	DRB1-1432	ENRLVVFEKGGVYLH	9	24
NEDD4L-TBC1D17	chr18	55919286	chr19	50381400	297	DRB1-1432	DENRLVVFEKGGVYL	8	23
NEDD4L-TBC1D17	chr18	55919286	chr19	50381400	297	DRB1-1432	FDENRLVVFEKGGVY	7	22
NEDD4L-TBC1D17	chr18	55919286	chr19	50381400	297	DRB1-1434	ENRLVVFEKGGVYLH	9	24
NEDD4L-TBC1D17	chr18	55919286	chr19	50381400	297	DRB1-1437	ENRLVVFEKGGVYLH	9	24
NEDD4L-TBC1D17	chr18	55919286	chr19	50381400	297	DRB1-1452	ENRLVVFEKGGVYLH	9	24
NEDD4L-TBC1D17	chr18	55919286	chr19	50381400	297	DRB1-1455	ENRLVVFEKGGVYLH	9	24
NEDD4L-TBC1D17	chr18	55919286	chr19	50381400	297	DRB1-1455	DENRLVVFEKGGVYL	8	23
NEDD4L-TBC1D17	chr18	55919286	chr19	50381400	297	DRB1-1455	FDENRLVVFEKGGVY	7	22
NEDD4L-TBC1D17	chr18	55919286	chr19	50381400	297	DRB1-1461	ENRLVVFEKGGVYLH	9	24
NEDD4L-TBC1D17	chr18	55919286	chr19	50381400	297	DRB1-1461	FDENRLVVFEKGGVY	7	22
NEDD4L-TBC1D17	chr18	55919286	chr19	50381400	297	DRB1-1461	DENRLVVFEKGGVYL	8	23
NEDD4L-TBC1D17	chr18	55919286	chr19	50381400	297	DRB1-1465	ENRLVVFEKGGVYLH	9	24
NEDD4L-TBC1D17	chr18	55919286	chr19	50381400	297	DRB1-1465	FDENRLVVFEKGGVY	7	22
NEDD4L-TBC1D17	chr18	55919286	chr19	50381400	297	DRB1-1465	DENRLVVFEKGGVYL	8	23
NEDD4L-TBC1D17	chr18	55919286	chr19	50381400	297	DRB1-1471	ENRLVVFEKGGVYLH	9	24
NEDD4L-TBC1D17	chr18	55919286	chr19	50381400	297	DRB1-1471	FDENRLVVFEKGGVY	7	22
NEDD4L-TBC1D17	chr18	55919286	chr19	50381400	297	DRB1-1471	DENRLVVFEKGGVYL	8	23
NEDD4L-TBC1D17	chr18	55919286	chr19	50381400	297	DRB1-1478	ENRLVVFEKGGVYLH	9	24
NEDD4L-TBC1D17	chr18	55919286	chr19	50381400	297	DRB1-1481	ENRLVVFEKGGVYLH	9	24
NEDD4L-TBC1D17	chr18	55919286	chr19	50381400	297	DRB1-1481	DENRLVVFEKGGVYL	8	23
NEDD4L-TBC1D17	chr18	55919286	chr19	50381400	297	DRB1-1483	ENRLVVFEKGGVYLH	9	24
NEDD4L-TBC1D17	chr18	55919286	chr19	50381400	297	DRB1-1529	HRLLFEVFDENRLVV	0	15
NEDD4L-TBC1D17	chr18	55919286	chr19	50381755	297	DRB1-1502	RLLFEVFDENRLDND	1	16
NEDD4L-TBC1D17	chr18	55919286	chr19	50381755	297	DRB1-1502	HRLLFEVFDENRLDN	0	15
NEDD4L-TBC1D17	chr18	55919286	chr19	50381755	297	DRB1-1503	RLLFEVFDENRLDND	1	16
NEDD4L-TBC1D17	chr18	55919286	chr19	50381755	297	DRB1-1503	HRLLFEVFDENRLDN	0	15
NEDD4L-TBC1D17	chr18	55919286	chr19	50381755	297	DRB1-1508	RLLFEVFDENRLDND	1	16
NEDD4L-TBC1D17	chr18	55919286	chr19	50381755	297	DRB1-1508	HRLLFEVFDENRLDN	0	15
NEDD4L-TBC1D17	chr18	55919286	chr19	50381755	297	DRB1-1511	RLLFEVFDENRLDND	1	16
NEDD4L-TBC1D17	chr18	55919286	chr19	50381755	297	DRB1-1511	HRLLFEVFDENRLDN	0	15
NEDD4L-TBC1D17	chr18	55919286	chr19	50381755	297	DRB1-1514	RLLFEVFDENRLDND	1	16
NEDD4L-TBC1D17	chr18	55919286	chr19	50381755	297	DRB1-1514	HRLLFEVFDENRLDN	0	15
NEDD4L-TBC1D17	chr18	55919286	chr19	50381755	297	DRB1-1515	RLLFEVFDENRLDND	1	16
NEDD4L-TBC1D17	chr18	55919286	chr19	50381755	297	DRB1-1515	HRLLFEVFDENRLDN	0	15
NEDD4L-TBC1D17	chr18	55919286	chr19	50381755	297	DRB1-1519	RLLFEVFDENRLDND	1	16
NEDD4L-TBC1D17	chr18	55919286	chr19	50381755	297	DRB1-1519	HRLLFEVFDENRLDN	0	15
NEDD4L-TBC1D17	chr18	55919286	chr19	50381755	297	DRB1-1523	RLLFEVFDENRLDND	1	16
NEDD4L-TBC1D17	chr18	55919286	chr19	50381755	297	DRB1-1523	HRLLFEVFDENRLDN	0	15
NEDD4L-TBC1D17	chr18	55919286	chr19	50381755	297	DRB1-1526	RLLFEVFDENRLDND	1	16
NEDD4L-TBC1D17	chr18	55919286	chr19	50381755	297	DRB1-1526	HRLLFEVFDENRLDN	0	15
NEDD4L-TBC1D17	chr18	55919286	chr19	50381755	297	DRB1-1527	RLLFEVFDENRLDND	1	16
NEDD4L-TBC1D17	chr18	55919286	chr19	50381755	297	DRB1-1527	HRLLFEVFDENRLDN	0	15
NEDD4L-TBC1D17	chr18	55919286	chr19	50381755	297	DRB1-1529	RLLFEVFDENRLDND	1	16
NEDD4L-TBC1D17	chr18	55919286	chr19	50381755	297	DRB1-1529	HRLLFEVFDENRLDN	0	15
NEDD4L-TBC1D17	chr18	55919286	chr19	50381755	297	DRB1-1529	LLFEVFDENRLDNDV	2	17
NEDD4L-TBC1D17	chr18	55919286	chr19	50381755	297	DRB1-1530	RLLFEVFDENRLDND	1	16
NEDD4L-TBC1D17	chr18	55919286	chr19	50381755	297	DRB1-1530	HRLLFEVFDENRLDN	0	15
NEDD4L-TBC1D17	chr18	55919286	chr19	50381755	297	DRB1-1531	RLLFEVFDENRLDND	1	16
NEDD4L-TBC1D17	chr18	55919286	chr19	50381755	297	DRB1-1531	HRLLFEVFDENRLDN	0	15
NEDD4L-TBC1D17	chr18	55919286	chr19	50381755	297	DRB1-1534	RLLFEVFDENRLDND	1	16
NEDD4L-TBC1D17	chr18	55919286	chr19	50381755	297	DRB1-1534	HRLLFEVFDENRLDN	0	15
NEDD4L-TBC1D17	chr18	55919286	chr19	50381755	297	DRB1-1538	RLLFEVFDENRLDND	1	16
NEDD4L-TBC1D17	chr18	55919286	chr19	50381755	297	DRB1-1538	HRLLFEVFDENRLDN	0	15
NEDD4L-TBC1D17	chr18	55919286	chr19	50381755	297	DRB1-1539	RLLFEVFDENRLDND	1	16
NEDD4L-TBC1D17	chr18	55919286	chr19	50381755	297	DRB1-1539	HRLLFEVFDENRLDN	0	15
NEDD4L-TBC1D17	chr18	55919286	chr19	50381755	297	DRB1-1544	RLLFEVFDENRLDND	1	16
NEDD4L-TBC1D17	chr18	55919286	chr19	50381755	297	DRB1-1544	HRLLFEVFDENRLDN	0	15
NEDD4L-TBC1D17	chr18	55919286	chr19	50381755	297	DRB1-1547	RLLFEVFDENRLDND	1	16
NEDD4L-TBC1D17	chr18	55919286	chr19	50381755	297	DRB1-1547	HRLLFEVFDENRLDN	0	15
NEDD4L-TBC1D17	chr18	55919286	chr19	50381755	297	DRB1-1602	RLLFEVFDENRLDND	1	16
NEDD4L-TBC1D17	chr18	55919286	chr19	50381755	297	DRB1-1605	RLLFEVFDENRLDND	1	16
NEDD4L-TBC1D17	chr18	55919286	chr19	50381755	297	DRB1-1607	RLLFEVFDENRLDND	1	16
NEDD4L-TBC1D17	chr18	55919286	chr19	50381755	297	DRB1-1609	RLLFEVFDENRLDND	1	16
NEDD4L-TBC1D17	chr18	55919286	chr19	50381755	297	DRB1-1610	RLLFEVFDENRLDND	1	16
NEDD4L-TBC1D17	chr18	55919286	chr19	50381755	297	DRB1-1610	HRLLFEVFDENRLDN	0	15
NEDD4L-TBC1D17	chr18	55919286	chr19	50381755	297	DRB1-1611	RLLFEVFDENRLDND	1	16
NEDD4L-TBC1D17	chr18	55919286	chr19	50381755	297	DRB1-1612	RLLFEVFDENRLDND	1	16
NEDD4L-TBC1D17	chr18	55919286	chr19	50381755	297	DRB1-1614	RLLFEVFDENRLDND	1	16
NEDD4L-TBC1D17	chr18	55919286	chr19	50381755	297	DRB1-1616	RLLFEVFDENRLDND	1	16

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Fusion breakpoint peptide structures of NEDD4L-TBC1D17

3D structures of the fusion breakpoint peptide of 14AA sequence that have potential fusion neoantigens
* The minimum length of the amino acid sequence in RoseTTAFold is 14AA. Here, we predicted the 14AA fusion protein breakpoint sequence not the fusion neoantigen peptide, which is shorter than 14 AA.

File name	BPseq	Hgene	Tgene	Hchr	Hbp	Tchr	Tbp	AAlen
9915	VFDENRLDNDVLLH	NEDD4L	TBC1D17	chr18	55919286	chr19	50381755	297

File name	BPseq	Hgene	Tgene	Hchr	Hbp	Tchr	Tbp	AAlen
9916	VFDENRLVVFEKGG	NEDD4L	TBC1D17	chr18	55919286	chr19	50381400	297

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Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D of NEDD4L-TBC1D17

Virtual screening between 25 HLAs (from PDB) and FusionNeoAntigens
* We used Glide to predict the interaction between HLAs and neoantigens.

HLA allele	PDB ID	File name	BPseq	Docking score	Glide score
HLA-B14:02	3BVN	9915	VFDENRLDNDVLLH	-7.15543	-7.26883
HLA-B14:02	3BVN	9915	VFDENRLDNDVLLH	-4.77435	-5.80965
HLA-B52:01	3W39	9915	VFDENRLDNDVLLH	-6.80875	-6.92215
HLA-B52:01	3W39	9915	VFDENRLDNDVLLH	-4.20386	-5.23916
HLA-A11:01	4UQ2	9915	VFDENRLDNDVLLH	-7.5194	-8.5547
HLA-A11:01	4UQ2	9915	VFDENRLDNDVLLH	-6.9601	-7.0735
HLA-A24:02	5HGA	9915	VFDENRLDNDVLLH	-7.52403	-7.63743
HLA-A24:02	5HGA	9915	VFDENRLDNDVLLH	-5.82433	-6.85963
HLA-B27:05	6PYJ	9915	VFDENRLDNDVLLH	-3.28285	-4.31815
HLA-B44:05	3DX8	9915	VFDENRLDNDVLLH	-5.91172	-6.94702
HLA-B44:05	3DX8	9915	VFDENRLDNDVLLH	-4.24346	-4.35686
HLA-B14:02	3BVN	9916	VFDENRLVVFEKGG	-7.15543	-7.26883
HLA-B14:02	3BVN	9916	VFDENRLVVFEKGG	-4.77435	-5.80965
HLA-B52:01	3W39	9916	VFDENRLVVFEKGG	-6.80875	-6.92215
HLA-B52:01	3W39	9916	VFDENRLVVFEKGG	-4.20386	-5.23916
HLA-A11:01	4UQ2	9916	VFDENRLVVFEKGG	-7.5194	-8.5547
HLA-A11:01	4UQ2	9916	VFDENRLVVFEKGG	-6.9601	-7.0735
HLA-A24:02	5HGA	9916	VFDENRLVVFEKGG	-7.52403	-7.63743
HLA-A24:02	5HGA	9916	VFDENRLVVFEKGG	-5.82433	-6.85963
HLA-B27:05	6PYJ	9916	VFDENRLVVFEKGG	-3.28285	-4.31815
HLA-B44:05	3DX8	9916	VFDENRLVVFEKGG	-5.91172	-6.94702
HLA-B44:05	3DX8	9916	VFDENRLVVFEKGG	-4.24346	-4.35686

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Vaccine Design for the FusionNeoAntigens of NEDD4L-TBC1D17

mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-Is.

Fusion gene	Hchr	Hbp	Tchr	Tbp	Start in +/-13AA	End in +/-13AA	FusionNeoAntigen peptide sequence	FusionNeoAntigen RNA sequence
NEDD4L-TBC1D17	chr18	55919286	chr19	50381400	11	22	RLVVFEKGGVY	AGACTGGTGGTGTTTGAGAAGGGCGGAGTGTAC
NEDD4L-TBC1D17	chr18	55919286	chr19	50381400	12	22	LVVFEKGGVY	CTGGTGGTGTTTGAGAAGGGCGGAGTGTAC
NEDD4L-TBC1D17	chr18	55919286	chr19	50381400	5	14	EVFDENRLV	GAAGTATTTGACGAAAATAGACTGGTG
NEDD4L-TBC1D17	chr18	55919286	chr19	50381400	5	15	EVFDENRLVV	GAAGTATTTGACGAAAATAGACTGGTGGTG
NEDD4L-TBC1D17	chr18	55919286	chr19	50381400	5	16	EVFDENRLVVF	GAAGTATTTGACGAAAATAGACTGGTGGTGTTT
NEDD4L-TBC1D17	chr18	55919286	chr19	50381400	6	14	VFDENRLV	GTATTTGACGAAAATAGACTGGTG
NEDD4L-TBC1D17	chr18	55919286	chr19	50381400	6	15	VFDENRLVV	GTATTTGACGAAAATAGACTGGTGGTG
NEDD4L-TBC1D17	chr18	55919286	chr19	50381400	6	16	VFDENRLVVF	GTATTTGACGAAAATAGACTGGTGGTGTTT
NEDD4L-TBC1D17	chr18	55919286	chr19	50381400	8	16	DENRLVVF	GACGAAAATAGACTGGTGGTGTTT
NEDD4L-TBC1D17	chr18	55919286	chr19	50381755	10	18	NRLDNDVL	AATAGACTGGACAATGACGTCCTC
NEDD4L-TBC1D17	chr18	55919286	chr19	50381755	10	19	NRLDNDVLL	AATAGACTGGACAATGACGTCCTCCTG
NEDD4L-TBC1D17	chr18	55919286	chr19	50381755	10	21	NRLDNDVLLHW	AATAGACTGGACAATGACGTCCTCCTGCACTGG
NEDD4L-TBC1D17	chr18	55919286	chr19	50381755	11	19	RLDNDVLL	AGACTGGACAATGACGTCCTCCTG
NEDD4L-TBC1D17	chr18	55919286	chr19	50381755	11	21	RLDNDVLLHW	AGACTGGACAATGACGTCCTCCTGCACTGG
NEDD4L-TBC1D17	chr18	55919286	chr19	50381755	12	21	LDNDVLLHW	CTGGACAATGACGTCCTCCTGCACTGG
NEDD4L-TBC1D17	chr18	55919286	chr19	50381755	9	19	ENRLDNDVLL	GAAAATAGACTGGACAATGACGTCCTCCTG

mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-IIs.

Fusion gene	Hchr	Hbp	Tchr	Tbp	Start in +/-13AA	End in +/-13AA	FusionNeoAntigen peptide	FusionNEoAntigen RNA sequence
NEDD4L-TBC1D17	chr18	55919286	chr19	50381400	0	15	HRLLFEVFDENRLVV	CACAGACTCCTATTTGAAGTATTTGACGAAAATAGACTGGTGGTG
NEDD4L-TBC1D17	chr18	55919286	chr19	50381400	7	22	FDENRLVVFEKGGVY	TTTGACGAAAATAGACTGGTGGTGTTTGAGAAGGGCGGAGTGTAC
NEDD4L-TBC1D17	chr18	55919286	chr19	50381400	8	23	DENRLVVFEKGGVYL	GACGAAAATAGACTGGTGGTGTTTGAGAAGGGCGGAGTGTACCTG
NEDD4L-TBC1D17	chr18	55919286	chr19	50381400	9	24	ENRLVVFEKGGVYLH	GAAAATAGACTGGTGGTGTTTGAGAAGGGCGGAGTGTACCTGCAC
NEDD4L-TBC1D17	chr18	55919286	chr19	50381755	0	15	HRLLFEVFDENRLDN	CACAGACTCCTATTTGAAGTATTTGACGAAAATAGACTGGACAAT
NEDD4L-TBC1D17	chr18	55919286	chr19	50381755	1	16	RLLFEVFDENRLDND	AGACTCCTATTTGAAGTATTTGACGAAAATAGACTGGACAATGAC
NEDD4L-TBC1D17	chr18	55919286	chr19	50381755	2	17	LLFEVFDENRLDNDV	CTCCTATTTGAAGTATTTGACGAAAATAGACTGGACAATGACGTC

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Information of the samples that have these potential fusion neoantigens of NEDD4L-TBC1D17

These samples were reported as having these fusion breakpoints. For individual breakpoints, we checked the open reading frames considering multiple gene isoforms and chose the in-frame fusion genes only. Then, we made fusion protein sequences and predicted the fusion neoantigens. These fusion-positive samples may have these potential fusion neoantigens.

Cancer type	Fusion gene	Hchr	Hbp	Henst	Tchr	Tbp	Tenst	Sample
OV	NEDD4L-TBC1D17	chr18	55919286	ENST00000256830	chr19	50381400	ENST00000221543	TCGA-24-1551-01A
OV	NEDD4L-TBC1D17	chr18	55919286	ENST00000256830	chr19	50381755	ENST00000221543	TCGA-24-1551-01A

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Potential target of CAR-T therapy development for NEDD4L-TBC1D17

Predicted 3D structure. We used RoseTTAFold.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, to provide the retention of the transmembrane domain, we only show the protein feature retention information of those transmembrane features

* Minus value of BPloci means that the break point is located before the CDS.

- In-frame and retained 'Transmembrane'.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Subcellular localization prediction of the transmembrane domain retained fusion proteins
* We used DeepLoc 1.0. The order of the X-axis of the barplot is as follows: Entry_ID, Localization, Type, Nucleus, Cytoplasm, Extracellular, Mitochondrion, Cell_membrane, Endoplasmic_reticulum, Plastid, Golgi.apparatus, Lysosome.Vacuole, Peroxisome. Y-axis is the output score of DeepLoc. Clicking the image will open a new tab with a large image.

Hgene

Hchr

Hbp

Henst

Tgene

Tchr

Tbp

Tenst

DeepLoc result

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Related Drugs to NEDD4L-TBC1D17

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to NEDD4L-TBC1D17

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source

	Fusion Gene and Fusion Protein Summary
	Fusion Amino Acid Sequences (multiple BPs and multiple gene isoforms)
	Fusion Protein Breakpoint Sequences - (for the Screening of the FusionNeoAntigens)
	Potential FusionNeoAntigens in HLA I - (netMHCpan v4.1 + deepHLApan v1.1)
	Potential FusionNeoAntigens in HLA II - (netMHCIIpan v4.1)
	Fusion Breakpoint 14 AA Peptide Structure - (RoseTTAFold)
	Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D - (Glide)
	Vaccine Design for the FusionNeoAntigens (RNA/protein sequences)
	Potential target of CAR-T therapy development
	Information on the samples that have these potential fusion neoantigens
	Fusion Protein Targeting Drugs - (Manual Curation)
	Fusion Protein Related diseases - (Manual Curation)