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Fusion Protein:NF1-SAFB2

Fusion Gene and Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: NF1-SAFB2
	FusionPDB ID: 58704
	FusionGDB2.0 ID: 58704
		Hgene	Tgene
	Gene symbol	NF1	SAFB2
	Gene ID	4763	9667
	Gene name	neurofibromin 1	scaffold attachment factor B2
	Synonyms	NFNS\|VRNF\|WSS	-
	Cytomap	17q11.2	19p13.3
	Type of gene	protein-coding	protein-coding
	Description	neurofibrominneurofibromatosis 1neurofibromatosis-related protein NF-1truncated neurofibromin 1	scaffold attachment factor B2
	Modification date	20200322	20200313
	UniProtAcc	P21359 Main function of 5'-partner protein: FUNCTION: Stimulates the GTPase activity of Ras. NF1 shows greater affinity for Ras GAP, but lower specific activity. May be a regulator of Ras activity. {ECO:0000269\|PubMed:2121371, ECO:0000269\|PubMed:8417346}.	.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000356175, ENST00000358273, ENST00000417592, ENST00000431387, ENST00000444181, ENST00000581113,	ENST00000591310, ENST00000252542,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	47 X 26 X 21=25662	8 X 8 X 5=320
	# samples	69	9
	** MAII score	log2(69/25662*10)=-5.21689344093196 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(9/320*10)=-1.83007499855769 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Fusion gene context	PubMed: NF1 [Title/Abstract] AND SAFB2 [Title/Abstract] AND fusion [Title/Abstract]
Fusion neoantigen context	PubMed: NF1 [Title/Abstract] AND SAFB2 [Title/Abstract] AND neoantigen [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	NF1(29592357)-SAFB2(5600271), # samples:1
Anticipated loss of major functional domain due to fusion event.	NF1-SAFB2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. NF1-SAFB2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. NF1-SAFB2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. NF1-SAFB2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	NF1	GO:0043547	positive regulation of GTPase activity	2121371

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:29592357/chr19:5600271)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Retention analysis results of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features, are available here.

Fusion gene breakpoints across NF1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across SAFB2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Amino Acid Sequences

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000356175

NF1

chr17

29592357

ENST00000252542

SAFB2

chr19

5600271

6702

5155

254

6457

2067

ENST00000358273

NF1

chr17

29592357

ENST00000252542

SAFB2

chr19

5600271

6765

5218

254

6520

2088

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000356175	ENST00000252542	NF1	chr17	29592357	+	SAFB2	chr19	5600271	-	0.001920785	0.9980792
ENST00000358273	ENST00000252542	NF1	chr17	29592357	+	SAFB2	chr19	5600271	-	0.000883249	0.9991167

Predicted full-length fusion amino acid sequences. For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among all the predicted ones.

Get the fusion protein sequences from here.

Fusion protein sequence information is available in the fasta format.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

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Fusion Protein Breakpoint Sequences for NF1-SAFB2

+/-13 AA sequence from the breakpoints of the fusion protein sequences.

Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	Length(fusion protein)	BP in fusion protein	Peptide
NF1	chr17	29592357	SAFB2	chr19	5600271	5155	1633	SKAGNPIFYYVARRTVIKKEEKIEKK
NF1	chr17	29592357	SAFB2	chr19	5600271	5155	1731	SKEKRDILSFDKIKEQRERERQRQRE
NF1	chr17	29592357	SAFB2	chr19	5600271	5218	1654	SKAGNPIFYYVARRTVIKKEEKIEKK
NF1	chr17	29592357	SAFB2	chr19	5600271	5218	1752	SKEKRDILSFDKIKEQRERERQRQRE

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Potential FusionNeoAntigen Information of NF1-SAFB2 in HLA I

Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.

NF1-SAFB2_29592357_5600271.msa

Potential FusionNeoAntigen Information
* We used NetMHCpan v4.1 (%rank<0.5) and deepHLApan v1.1 (immunogenic score>0.5)

Fusion gene	Hchr	Hbp	Tgene	Tchr	Tbp	HLA I	FusionNeoAntigen peptide	Binding score	Immunogenic score	Neoantigen start (at BP 13)	Neoantigen end (at BP 13)
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	HLA-A30:08	VARRTVIKK	0.9944	0.6485	10	19
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	HLA-A30:08	YVARRTVIK	0.9721	0.6678	9	18
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	HLA-C07:80	YYVARRTVI	0.2104	0.8871	8	17
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	HLA-C07:67	YYVARRTVI	0.2104	0.8871	8	17
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	HLA-C07:10	YYVARRTVI	0.2081	0.9041	8	17
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	HLA-C07:29	YYVARRTVI	0.1708	0.8501	8	17
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	HLA-C07:05	FYYVARRTV	0.1424	0.9454	7	16
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	HLA-C07:05	YYVARRTVI	0.1296	0.8764	8	17
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	HLA-C12:16	FYYVARRTV	0.1236	0.9584	7	16
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	HLA-C12:16	YYVARRTVI	0.1183	0.9451	8	17
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	HLA-C07:13	YYVARRTVI	0.0976	0.8044	8	17
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	HLA-C07:10	FYYVARRTV	0.0869	0.936	7	16
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	HLA-C07:46	FYYVARRTV	0.0859	0.8337	7	16
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	HLA-C07:80	FYYVARRTV	0.0848	0.9095	7	16
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	HLA-C07:67	FYYVARRTV	0.0848	0.9095	7	16
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	HLA-C07:19	FYYVARRTV	0.0769	0.6907	7	16
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	HLA-C07:27	YYVARRTVI	0.0585	0.8799	8	17
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	HLA-C07:29	FYYVARRTV	0.0273	0.9278	7	16
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	HLA-C07:13	FYYVARRTV	0.0234	0.8594	7	16
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	HLA-C07:27	FYYVARRTV	0.0161	0.9403	7	16
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	HLA-C14:02	YYVARRTV	0.5149	0.9178	8	16
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	HLA-C14:03	YYVARRTV	0.5149	0.9178	8	16
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	HLA-A30:01	VARRTVIKK	0.9946	0.8267	10	19
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	HLA-A30:01	YVARRTVIK	0.9704	0.8157	9	18
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	HLA-C03:67	YYVARRTVI	0.3189	0.9573	8	17
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	HLA-C06:02	FYYVARRTV	0.3079	0.9928	7	16
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	HLA-C06:17	FYYVARRTV	0.3079	0.9928	7	16
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	HLA-C06:02	YYVARRTVI	0.2702	0.9921	8	17
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	HLA-C06:17	YYVARRTVI	0.2702	0.9921	8	17
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	HLA-C07:02	YYVARRTVI	0.2104	0.8871	8	17
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	HLA-C07:04	YYVARRTVI	0.1971	0.8093	8	17
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	HLA-C07:17	YYVARRTVI	0.1834	0.9296	8	17
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	HLA-C06:08	FYYVARRTV	0.1619	0.9905	7	16
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	HLA-C14:02	YYVARRTVI	0.1205	0.9116	8	17
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	HLA-C14:03	YYVARRTVI	0.1205	0.9116	8	17
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	HLA-C03:67	FYYVARRTV	0.1142	0.9684	7	16
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	HLA-C06:06	YYVARRTVI	0.1091	0.9746	8	17
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	HLA-C06:08	YYVARRTVI	0.1064	0.9846	8	17
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	HLA-C07:02	FYYVARRTV	0.0848	0.9095	7	16
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	HLA-C07:04	FYYVARRTV	0.0751	0.9399	7	16
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	HLA-C06:06	FYYVARRTV	0.0734	0.9807	7	16
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	HLA-C07:17	FYYVARRTV	0.029	0.9637	7	16
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	HLA-C07:01	FYYVARRTV	0.0209	0.6908	7	16
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	HLA-C14:03	FYYVARRTV	0.017	0.9382	7	16
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	HLA-C14:02	FYYVARRTV	0.017	0.9382	7	16

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Potential FusionNeoAntigen Information of NF1-SAFB2 in HLA II

NF1-SAFB2_29592357_5600271.msa

Potential FusionNeoAntigen Information
* We used NetMHCIIpan v4.1 (%rank<0.5).

Fusion gene	Hchr	Hbp	Tgene	Tchr	Tbp	HLA II	FusionNeoAntigen peptide	Neoantigen start (at BP 13)	Neoantigen end (at BP 13)
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-0802	NPIFYYVARRTVIKK	4	19
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-0803	NPIFYYVARRTVIKK	4	19
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-0807	NPIFYYVARRTVIKK	4	19
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-0807	GNPIFYYVARRTVIK	3	18
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-0807	PIFYYVARRTVIKKE	5	20
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-0808	NPIFYYVARRTVIKK	4	19
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-0808	GNPIFYYVARRTVIK	3	18
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-0809	NPIFYYVARRTVIKK	4	19
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-0811	NPIFYYVARRTVIKK	4	19
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-0811	GNPIFYYVARRTVIK	3	18
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-0813	NPIFYYVARRTVIKK	4	19
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-0813	PIFYYVARRTVIKKE	5	20
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-0814	NPIFYYVARRTVIKK	4	19
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-0815	NPIFYYVARRTVIKK	4	19
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-0815	PIFYYVARRTVIKKE	5	20
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-0815	GNPIFYYVARRTVIK	3	18
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-0819	NPIFYYVARRTVIKK	4	19
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-0819	GNPIFYYVARRTVIK	3	18
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-0821	NPIFYYVARRTVIKK	4	19
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-0823	NPIFYYVARRTVIKK	4	19
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-0824	NPIFYYVARRTVIKK	4	19
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-0825	NPIFYYVARRTVIKK	4	19
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-0827	NPIFYYVARRTVIKK	4	19
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-0829	NPIFYYVARRTVIKK	4	19
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-0829	PIFYYVARRTVIKKE	5	20
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-0830	NPIFYYVARRTVIKK	4	19
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-0830	PIFYYVARRTVIKKE	5	20
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-0830	GNPIFYYVARRTVIK	3	18
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-0833	NPIFYYVARRTVIKK	4	19
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-0834	NPIFYYVARRTVIKK	4	19
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-0834	GNPIFYYVARRTVIK	3	18
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-0835	NPIFYYVARRTVIKK	4	19
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-0836	NPIFYYVARRTVIKK	4	19
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-0837	NPIFYYVARRTVIKK	4	19
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-0837	GNPIFYYVARRTVIK	3	18
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-0837	PIFYYVARRTVIKKE	5	20
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-0838	NPIFYYVARRTVIKK	4	19
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1101	NPIFYYVARRTVIKK	4	19
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1105	NPIFYYVARRTVIKK	4	19
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1108	NPIFYYVARRTVIKK	4	19
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1108	GNPIFYYVARRTVIK	3	18
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1108	PIFYYVARRTVIKKE	5	20
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1109	NPIFYYVARRTVIKK	4	19
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1110	NPIFYYVARRTVIKK	4	19
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1111	NPIFYYVARRTVIKK	4	19
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1111	GNPIFYYVARRTVIK	3	18
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1111	PIFYYVARRTVIKKE	5	20
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1112	NPIFYYVARRTVIKK	4	19
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1114	NPIFYYVARRTVIKK	4	19
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1114	GNPIFYYVARRTVIK	3	18
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1114	PIFYYVARRTVIKKE	5	20
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1115	NPIFYYVARRTVIKK	4	19
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1119	NPIFYYVARRTVIKK	4	19
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1119	GNPIFYYVARRTVIK	3	18
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1119	PIFYYVARRTVIKKE	5	20
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1120	NPIFYYVARRTVIKK	4	19
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1120	GNPIFYYVARRTVIK	3	18
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1120	PIFYYVARRTVIKKE	5	20
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1124	NPIFYYVARRTVIKK	4	19
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1127	NPIFYYVARRTVIKK	4	19
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1127	GNPIFYYVARRTVIK	3	18
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1127	PIFYYVARRTVIKKE	5	20
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1128	NPIFYYVARRTVIKK	4	19
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1129	NPIFYYVARRTVIKK	4	19
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1131	NPIFYYVARRTVIKK	4	19
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1131	GNPIFYYVARRTVIK	3	18
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1131	PIFYYVARRTVIKKE	5	20
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1132	NPIFYYVARRTVIKK	4	19
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1132	GNPIFYYVARRTVIK	3	18
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1133	NPIFYYVARRTVIKK	4	19
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1137	NPIFYYVARRTVIKK	4	19
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1139	NPIFYYVARRTVIKK	4	19
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1145	NPIFYYVARRTVIKK	4	19
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1145	GNPIFYYVARRTVIK	3	18
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1145	PIFYYVARRTVIKKE	5	20
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1149	NPIFYYVARRTVIKK	4	19
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1151	NPIFYYVARRTVIKK	4	19
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1153	NPIFYYVARRTVIKK	4	19
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1153	PIFYYVARRTVIKKE	5	20
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1161	NPIFYYVARRTVIKK	4	19
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1162	NPIFYYVARRTVIKK	4	19
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1164	NPIFYYVARRTVIKK	4	19
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1164	PIFYYVARRTVIKKE	5	20
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1164	GNPIFYYVARRTVIK	3	18
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1166	NPIFYYVARRTVIKK	4	19
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1168	NPIFYYVARRTVIKK	4	19
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1168	GNPIFYYVARRTVIK	3	18
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1168	PIFYYVARRTVIKKE	5	20
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1169	NPIFYYVARRTVIKK	4	19
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1169	GNPIFYYVARRTVIK	3	18
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1169	PIFYYVARRTVIKKE	5	20
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1172	NPIFYYVARRTVIKK	4	19
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1172	PIFYYVARRTVIKKE	5	20
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1172	GNPIFYYVARRTVIK	3	18
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1173	NPIFYYVARRTVIKK	4	19
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1173	GNPIFYYVARRTVIK	3	18
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1173	PIFYYVARRTVIKKE	5	20
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1174	NPIFYYVARRTVIKK	4	19
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1175	NPIFYYVARRTVIKK	4	19
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1179	NPIFYYVARRTVIKK	4	19
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1180	NPIFYYVARRTVIKK	4	19
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1181	NPIFYYVARRTVIKK	4	19
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1182	NPIFYYVARRTVIKK	4	19
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1182	GNPIFYYVARRTVIK	3	18
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1182	PIFYYVARRTVIKKE	5	20
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1186	NPIFYYVARRTVIKK	4	19
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1187	NPIFYYVARRTVIKK	4	19
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1190	NPIFYYVARRTVIKK	4	19
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1191	NPIFYYVARRTVIKK	4	19
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1193	NPIFYYVARRTVIKK	4	19
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1194	NPIFYYVARRTVIKK	4	19
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1195	NPIFYYVARRTVIKK	4	19
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1196	NPIFYYVARRTVIKK	4	19
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1302	NPIFYYVARRTVIKK	4	19
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1302	GNPIFYYVARRTVIK	3	18
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1302	PIFYYVARRTVIKKE	5	20
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1305	NPIFYYVARRTVIKK	4	19
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1307	NPIFYYVARRTVIKK	4	19
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-13100	NPIFYYVARRTVIKK	4	19
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-13100	GNPIFYYVARRTVIK	3	18
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-13100	PIFYYVARRTVIKKE	5	20
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-13101	NPIFYYVARRTVIKK	4	19
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1310	NPIFYYVARRTVIKK	4	19
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1313	NPIFYYVARRTVIKK	4	19
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1314	NPIFYYVARRTVIKK	4	19
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1316	NPIFYYVARRTVIKK	4	19
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1321	NPIFYYVARRTVIKK	4	19
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1323	NPIFYYVARRTVIKK	4	19
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1323	GNPIFYYVARRTVIK	3	18
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1323	PIFYYVARRTVIKKE	5	20
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1326	NPIFYYVARRTVIKK	4	19
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1326	PIFYYVARRTVIKKE	5	20
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1326	GNPIFYYVARRTVIK	3	18
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1329	NPIFYYVARRTVIKK	4	19
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1329	GNPIFYYVARRTVIK	3	18
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1329	PIFYYVARRTVIKKE	5	20
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1330	NPIFYYVARRTVIKK	4	19
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1331	NPIFYYVARRTVIKK	4	19
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1331	GNPIFYYVARRTVIK	3	18
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1331	PIFYYVARRTVIKKE	5	20
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1334	NPIFYYVARRTVIKK	4	19
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1334	GNPIFYYVARRTVIK	3	18
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1334	PIFYYVARRTVIKKE	5	20
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1336	NPIFYYVARRTVIKK	4	19
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1336	GNPIFYYVARRTVIK	3	18
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1336	PIFYYVARRTVIKKE	5	20
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1337	NPIFYYVARRTVIKK	4	19
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1338	NPIFYYVARRTVIKK	4	19
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1339	NPIFYYVARRTVIKK	4	19
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1339	GNPIFYYVARRTVIK	3	18
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1339	PIFYYVARRTVIKKE	5	20
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1341	NPIFYYVARRTVIKK	4	19
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1341	PIFYYVARRTVIKKE	5	20
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1346	NPIFYYVARRTVIKK	4	19
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1346	GNPIFYYVARRTVIK	3	18
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1346	PIFYYVARRTVIKKE	5	20
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1347	NPIFYYVARRTVIKK	4	19
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1349	NPIFYYVARRTVIKK	4	19
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1350	NPIFYYVARRTVIKK	4	19
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1355	NPIFYYVARRTVIKK	4	19
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1356	NPIFYYVARRTVIKK	4	19
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1356	GNPIFYYVARRTVIK	3	18
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1356	PIFYYVARRTVIKKE	5	20
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1360	NPIFYYVARRTVIKK	4	19
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1362	NPIFYYVARRTVIKK	4	19
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1363	NPIFYYVARRTVIKK	4	19
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1363	GNPIFYYVARRTVIK	3	18
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1363	PIFYYVARRTVIKKE	5	20
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1365	NPIFYYVARRTVIKK	4	19
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1366	NPIFYYVARRTVIKK	4	19
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1367	NPIFYYVARRTVIKK	4	19
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1367	PIFYYVARRTVIKKE	5	20
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1367	GNPIFYYVARRTVIK	3	18
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1373	NPIFYYVARRTVIKK	4	19
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1373	GNPIFYYVARRTVIK	3	18
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1373	PIFYYVARRTVIKKE	5	20
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1374	NPIFYYVARRTVIKK	4	19
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1374	GNPIFYYVARRTVIK	3	18
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1374	PIFYYVARRTVIKKE	5	20
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1382	NPIFYYVARRTVIKK	4	19
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1382	GNPIFYYVARRTVIK	3	18
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1382	PIFYYVARRTVIKKE	5	20
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1385	NPIFYYVARRTVIKK	4	19
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1385	PIFYYVARRTVIKKE	5	20
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1386	NPIFYYVARRTVIKK	4	19
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1386	PIFYYVARRTVIKKE	5	20
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1386	GNPIFYYVARRTVIK	3	18
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1396	NPIFYYVARRTVIKK	4	19
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1396	PIFYYVARRTVIKKE	5	20
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1396	GNPIFYYVARRTVIK	3	18
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1397	NPIFYYVARRTVIKK	4	19
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1397	GNPIFYYVARRTVIK	3	18
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1397	PIFYYVARRTVIKKE	5	20
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1399	NPIFYYVARRTVIKK	4	19
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1399	GNPIFYYVARRTVIK	3	18
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1399	PIFYYVARRTVIKKE	5	20
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1402	NPIFYYVARRTVIKK	4	19
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1402	PIFYYVARRTVIKKE	5	20
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1403	NPIFYYVARRTVIKK	4	19
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1403	PIFYYVARRTVIKKE	5	20
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1403	GNPIFYYVARRTVIK	3	18
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1407	NPIFYYVARRTVIKK	4	19
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1407	PIFYYVARRTVIKKE	5	20
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1407	GNPIFYYVARRTVIK	3	18
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1407	AGNPIFYYVARRTVI	2	17
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1407	IFYYVARRTVIKKEE	6	21
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1409	NPIFYYVARRTVIKK	4	19
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1413	NPIFYYVARRTVIKK	4	19
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1414	NPIFYYVARRTVIKK	4	19
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1414	PIFYYVARRTVIKKE	5	20
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1414	GNPIFYYVARRTVIK	3	18
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1422	NPIFYYVARRTVIKK	4	19
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1422	GNPIFYYVARRTVIK	3	18
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1424	NPIFYYVARRTVIKK	4	19
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1424	GNPIFYYVARRTVIK	3	18
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1424	PIFYYVARRTVIKKE	5	20
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1425	NPIFYYVARRTVIKK	4	19
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1425	GNPIFYYVARRTVIK	3	18
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1427	NPIFYYVARRTVIKK	4	19
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1427	PIFYYVARRTVIKKE	5	20
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1427	GNPIFYYVARRTVIK	3	18
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1430	NPIFYYVARRTVIKK	4	19
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1430	PIFYYVARRTVIKKE	5	20
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1436	NPIFYYVARRTVIKK	4	19
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1436	PIFYYVARRTVIKKE	5	20
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1436	GNPIFYYVARRTVIK	3	18
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1440	NPIFYYVARRTVIKK	4	19
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1440	PIFYYVARRTVIKKE	5	20
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1440	GNPIFYYVARRTVIK	3	18
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1441	NPIFYYVARRTVIKK	4	19
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1441	PIFYYVARRTVIKKE	5	20
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1442	NPIFYYVARRTVIKK	4	19
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1442	PIFYYVARRTVIKKE	5	20
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1442	GNPIFYYVARRTVIK	3	18
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1442	AGNPIFYYVARRTVI	2	17
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1442	IFYYVARRTVIKKEE	6	21
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1444	NPIFYYVARRTVIKK	4	19
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1444	PIFYYVARRTVIKKE	5	20
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1444	GNPIFYYVARRTVIK	3	18
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1449	NPIFYYVARRTVIKK	4	19
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1449	PIFYYVARRTVIKKE	5	20
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1449	GNPIFYYVARRTVIK	3	18
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1451	NPIFYYVARRTVIKK	4	19
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1451	PIFYYVARRTVIKKE	5	20
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1451	GNPIFYYVARRTVIK	3	18
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1453	NPIFYYVARRTVIKK	4	19
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1453	GNPIFYYVARRTVIK	3	18
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1453	PIFYYVARRTVIKKE	5	20
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1463	NPIFYYVARRTVIKK	4	19
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1463	PIFYYVARRTVIKKE	5	20
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1463	GNPIFYYVARRTVIK	3	18
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1467	NPIFYYVARRTVIKK	4	19
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1467	PIFYYVARRTVIKKE	5	20
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1467	GNPIFYYVARRTVIK	3	18
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1467	IFYYVARRTVIKKEE	6	21
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1468	NPIFYYVARRTVIKK	4	19
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1468	PIFYYVARRTVIKKE	5	20
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1468	GNPIFYYVARRTVIK	3	18
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1468	AGNPIFYYVARRTVI	2	17
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1469	NPIFYYVARRTVIKK	4	19
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1469	PIFYYVARRTVIKKE	5	20
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1469	GNPIFYYVARRTVIK	3	18
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1477	NPIFYYVARRTVIKK	4	19
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1477	PIFYYVARRTVIKKE	5	20
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1477	GNPIFYYVARRTVIK	3	18
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1485	NPIFYYVARRTVIKK	4	19
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1485	PIFYYVARRTVIKKE	5	20
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1489	NPIFYYVARRTVIKK	4	19
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1489	PIFYYVARRTVIKKE	5	20
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1493	NPIFYYVARRTVIKK	4	19
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1493	PIFYYVARRTVIKKE	5	20
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1493	GNPIFYYVARRTVIK	3	18
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1494	NPIFYYVARRTVIKK	4	19
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1494	PIFYYVARRTVIKKE	5	20
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1498	NPIFYYVARRTVIKK	4	19
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1498	PIFYYVARRTVIKKE	5	20
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1498	GNPIFYYVARRTVIK	3	18
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1498	IFYYVARRTVIKKEE	6	21
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1501	GNPIFYYVARRTVIK	3	18
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1501	AGNPIFYYVARRTVI	2	17
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1501	KAGNPIFYYVARRTV	1	16
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1501	NPIFYYVARRTVIKK	4	19
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1502	GNPIFYYVARRTVIK	3	18
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1502	AGNPIFYYVARRTVI	2	17
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1503	GNPIFYYVARRTVIK	3	18
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1504	GNPIFYYVARRTVIK	3	18
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1504	AGNPIFYYVARRTVI	2	17
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1504	KAGNPIFYYVARRTV	1	16
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1504	NPIFYYVARRTVIKK	4	19
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1505	GNPIFYYVARRTVIK	3	18
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1505	AGNPIFYYVARRTVI	2	17
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1505	KAGNPIFYYVARRTV	1	16
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1505	NPIFYYVARRTVIKK	4	19
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1506	GNPIFYYVARRTVIK	3	18
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1506	AGNPIFYYVARRTVI	2	17
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1506	KAGNPIFYYVARRTV	1	16
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1506	NPIFYYVARRTVIKK	4	19
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1507	GNPIFYYVARRTVIK	3	18
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1507	AGNPIFYYVARRTVI	2	17
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1507	KAGNPIFYYVARRTV	1	16
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1508	GNPIFYYVARRTVIK	3	18
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1508	AGNPIFYYVARRTVI	2	17
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1509	GNPIFYYVARRTVIK	3	18
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1509	AGNPIFYYVARRTVI	2	17
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1509	KAGNPIFYYVARRTV	1	16
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1509	NPIFYYVARRTVIKK	4	19
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1510	GNPIFYYVARRTVIK	3	18
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1510	AGNPIFYYVARRTVI	2	17
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1510	KAGNPIFYYVARRTV	1	16
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1510	NPIFYYVARRTVIKK	4	19
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1511	GNPIFYYVARRTVIK	3	18
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1512	GNPIFYYVARRTVIK	3	18
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1512	AGNPIFYYVARRTVI	2	17
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1512	KAGNPIFYYVARRTV	1	16
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1513	GNPIFYYVARRTVIK	3	18
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1513	AGNPIFYYVARRTVI	2	17
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1513	KAGNPIFYYVARRTV	1	16
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1513	NPIFYYVARRTVIKK	4	19
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1514	GNPIFYYVARRTVIK	3	18
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1514	AGNPIFYYVARRTVI	2	17
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1515	GNPIFYYVARRTVIK	3	18
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1515	AGNPIFYYVARRTVI	2	17
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1516	GNPIFYYVARRTVIK	3	18
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1516	AGNPIFYYVARRTVI	2	17
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1516	KAGNPIFYYVARRTV	1	16
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1516	NPIFYYVARRTVIKK	4	19
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1518	GNPIFYYVARRTVIK	3	18
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1518	AGNPIFYYVARRTVI	2	17
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1518	KAGNPIFYYVARRTV	1	16
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1518	NPIFYYVARRTVIKK	4	19
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1519	GNPIFYYVARRTVIK	3	18
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1519	AGNPIFYYVARRTVI	2	17
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1520	GNPIFYYVARRTVIK	3	18
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1520	AGNPIFYYVARRTVI	2	17
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1520	KAGNPIFYYVARRTV	1	16
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1520	NPIFYYVARRTVIKK	4	19
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1521	GNPIFYYVARRTVIK	3	18
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1521	AGNPIFYYVARRTVI	2	17
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1521	KAGNPIFYYVARRTV	1	16
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1521	NPIFYYVARRTVIKK	4	19
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1522	GNPIFYYVARRTVIK	3	18
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1522	AGNPIFYYVARRTVI	2	17
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1522	KAGNPIFYYVARRTV	1	16
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1522	NPIFYYVARRTVIKK	4	19
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1523	GNPIFYYVARRTVIK	3	18
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1524	GNPIFYYVARRTVIK	3	18
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1524	AGNPIFYYVARRTVI	2	17
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1524	KAGNPIFYYVARRTV	1	16
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1524	NPIFYYVARRTVIKK	4	19
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1526	GNPIFYYVARRTVIK	3	18
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1526	AGNPIFYYVARRTVI	2	17
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1528	GNPIFYYVARRTVIK	3	18
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1528	AGNPIFYYVARRTVI	2	17
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1528	KAGNPIFYYVARRTV	1	16
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1528	NPIFYYVARRTVIKK	4	19
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1530	GNPIFYYVARRTVIK	3	18
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1530	AGNPIFYYVARRTVI	2	17
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1531	GNPIFYYVARRTVIK	3	18
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1532	GNPIFYYVARRTVIK	3	18
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1532	AGNPIFYYVARRTVI	2	17
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1532	KAGNPIFYYVARRTV	1	16
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1532	NPIFYYVARRTVIKK	4	19
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1533	GNPIFYYVARRTVIK	3	18
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1533	AGNPIFYYVARRTVI	2	17
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1533	KAGNPIFYYVARRTV	1	16
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1533	NPIFYYVARRTVIKK	4	19
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1535	GNPIFYYVARRTVIK	3	18
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1535	AGNPIFYYVARRTVI	2	17
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1535	KAGNPIFYYVARRTV	1	16
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1535	NPIFYYVARRTVIKK	4	19
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1536	GNPIFYYVARRTVIK	3	18
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1536	AGNPIFYYVARRTVI	2	17
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1536	KAGNPIFYYVARRTV	1	16
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1536	NPIFYYVARRTVIKK	4	19
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1537	GNPIFYYVARRTVIK	3	18
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1537	AGNPIFYYVARRTVI	2	17
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1537	KAGNPIFYYVARRTV	1	16
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1537	NPIFYYVARRTVIKK	4	19
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1538	GNPIFYYVARRTVIK	3	18
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1538	AGNPIFYYVARRTVI	2	17
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1539	GNPIFYYVARRTVIK	3	18
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1539	AGNPIFYYVARRTVI	2	17
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1540	GNPIFYYVARRTVIK	3	18
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1540	AGNPIFYYVARRTVI	2	17
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1540	KAGNPIFYYVARRTV	1	16
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1540	NPIFYYVARRTVIKK	4	19
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1541	GNPIFYYVARRTVIK	3	18
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1541	AGNPIFYYVARRTVI	2	17
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1541	KAGNPIFYYVARRTV	1	16
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1541	NPIFYYVARRTVIKK	4	19
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1542	GNPIFYYVARRTVIK	3	18
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1542	AGNPIFYYVARRTVI	2	17
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1542	KAGNPIFYYVARRTV	1	16
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1542	NPIFYYVARRTVIKK	4	19
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1543	GNPIFYYVARRTVIK	3	18
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1543	AGNPIFYYVARRTVI	2	17
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1543	KAGNPIFYYVARRTV	1	16
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1543	NPIFYYVARRTVIKK	4	19
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1544	GNPIFYYVARRTVIK	3	18
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1544	AGNPIFYYVARRTVI	2	17
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1545	GNPIFYYVARRTVIK	3	18
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1545	AGNPIFYYVARRTVI	2	17
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1545	KAGNPIFYYVARRTV	1	16
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1545	NPIFYYVARRTVIKK	4	19
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1546	GNPIFYYVARRTVIK	3	18
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1546	AGNPIFYYVARRTVI	2	17
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1546	KAGNPIFYYVARRTV	1	16
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1546	NPIFYYVARRTVIKK	4	19
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1547	GNPIFYYVARRTVIK	3	18
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1547	AGNPIFYYVARRTVI	2	17
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1548	GNPIFYYVARRTVIK	3	18
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1548	AGNPIFYYVARRTVI	2	17
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1548	KAGNPIFYYVARRTV	1	16
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1549	GNPIFYYVARRTVIK	3	18
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1549	AGNPIFYYVARRTVI	2	17
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1549	KAGNPIFYYVARRTV	1	16
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB1-1549	NPIFYYVARRTVIKK	4	19
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB5-0103	IFYYVARRTVIKKEE	6	21
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB5-0103	GNPIFYYVARRTVIK	3	18
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB5-0202	GNPIFYYVARRTVIK	3	18
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB5-0202	AGNPIFYYVARRTVI	2	17
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB5-0203	GNPIFYYVARRTVIK	3	18
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB5-0204	GNPIFYYVARRTVIK	3	18
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB5-0204	AGNPIFYYVARRTVI	2	17
NF1-SAFB2	chr17	29592357	chr19	5600271	5155	DRB5-0204	KAGNPIFYYVARRTV	1	16

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Fusion breakpoint peptide structures of NF1-SAFB2

3D structures of the fusion breakpoint peptide of 14AA sequence that have potential fusion neoantigens
* The minimum length of the amino acid sequence in RoseTTAFold is 14AA. Here, we predicted the 14AA fusion protein breakpoint sequence not the fusion neoantigen peptide, which is shorter than 14 AA.

File name	BPseq	Hgene	Tgene	Hchr	Hbp	Tchr	Tbp	AAlen
3681	IFYYVARRTVIKKE	NF1	SAFB2	chr17	29592357	chr19	5600271	5155

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Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D of NF1-SAFB2

Virtual screening between 25 HLAs (from PDB) and FusionNeoAntigens
* We used Glide to predict the interaction between HLAs and neoantigens.

HLA allele	PDB ID	File name	BPseq	Docking score	Glide score
HLA-B14:02	3BVN	3681	IFYYVARRTVIKKE	-7.29174	-7.40514
HLA-B14:02	3BVN	3681	IFYYVARRTVIKKE	-4.74919	-5.78449
HLA-B52:01	3W39	3681	IFYYVARRTVIKKE	-5.07451	-5.18791
HLA-B52:01	3W39	3681	IFYYVARRTVIKKE	-2.86294	-3.89824
HLA-A11:01	4UQ2	3681	IFYYVARRTVIKKE	-4.62205	-5.65735
HLA-A24:02	5HGA	3681	IFYYVARRTVIKKE	-11.701	-11.8144
HLA-A24:02	5HGA	3681	IFYYVARRTVIKKE	-4.6967	-5.732
HLA-B44:05	3DX8	3681	IFYYVARRTVIKKE	-5.76162	-5.87502
HLA-B44:05	3DX8	3681	IFYYVARRTVIKKE	-3.98447	-5.01977
HLA-A02:01	6TDR	3681	IFYYVARRTVIKKE	-2.29826	-3.33356

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Vaccine Design for the FusionNeoAntigens of NF1-SAFB2

mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-Is.

Fusion gene	Hchr	Hbp	Tchr	Tbp	Start in +/-13AA	End in +/-13AA	FusionNeoAntigen peptide sequence	FusionNeoAntigen RNA sequence
NF1-SAFB2	chr17	29592357	chr19	5600271	10	19	VARRTVIKK	TGCACGGAGAACTGTAATTAAGAAGGA
NF1-SAFB2	chr17	29592357	chr19	5600271	7	16	FYYVARRTV	TTATTATGTTGCACGGAGAACTGTAAT
NF1-SAFB2	chr17	29592357	chr19	5600271	8	16	YYVARRTV	TTATGTTGCACGGAGAACTGTAAT
NF1-SAFB2	chr17	29592357	chr19	5600271	8	17	YYVARRTVI	TTATGTTGCACGGAGAACTGTAATTAA
NF1-SAFB2	chr17	29592357	chr19	5600271	9	18	YVARRTVIK	TGTTGCACGGAGAACTGTAATTAAGAA

mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-IIs.

Fusion gene	Hchr	Hbp	Tchr	Tbp	Start in +/-13AA	End in +/-13AA	FusionNeoAntigen peptide	FusionNEoAntigen RNA sequence
NF1-SAFB2	chr17	29592357	chr19	5600271	1	16	KAGNPIFYYVARRTV	AGCTGGGAATCCTATTTTTTATTATGTTGCACGGAGAACTGTAAT
NF1-SAFB2	chr17	29592357	chr19	5600271	2	17	AGNPIFYYVARRTVI	TGGGAATCCTATTTTTTATTATGTTGCACGGAGAACTGTAATTAA
NF1-SAFB2	chr17	29592357	chr19	5600271	3	18	GNPIFYYVARRTVIK	GAATCCTATTTTTTATTATGTTGCACGGAGAACTGTAATTAAGAA
NF1-SAFB2	chr17	29592357	chr19	5600271	4	19	NPIFYYVARRTVIKK	TCCTATTTTTTATTATGTTGCACGGAGAACTGTAATTAAGAAGGA
NF1-SAFB2	chr17	29592357	chr19	5600271	5	20	PIFYYVARRTVIKKE	TATTTTTTATTATGTTGCACGGAGAACTGTAATTAAGAAGGAAGA
NF1-SAFB2	chr17	29592357	chr19	5600271	6	21	IFYYVARRTVIKKEE	TTTTTATTATGTTGCACGGAGAACTGTAATTAAGAAGGAAGAGAA

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Information of the samples that have these potential fusion neoantigens of NF1-SAFB2

These samples were reported as having these fusion breakpoints. For individual breakpoints, we checked the open reading frames considering multiple gene isoforms and chose the in-frame fusion genes only. Then, we made fusion protein sequences and predicted the fusion neoantigens. These fusion-positive samples may have these potential fusion neoantigens.

Cancer type	Fusion gene	Hchr	Hbp	Henst	Tchr	Tbp	Tenst	Sample
STAD	NF1-SAFB2	chr17	29592357	ENST00000356175	chr19	5600271	ENST00000252542	TCGA-BR-A44T-01A

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Potential target of CAR-T therapy development for NF1-SAFB2

Predicted 3D structure. We used RoseTTAFold.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, to provide the retention of the transmembrane domain, we only show the protein feature retention information of those transmembrane features

* Minus value of BPloci means that the break point is located before the CDS.

- In-frame and retained 'Transmembrane'.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Subcellular localization prediction of the transmembrane domain retained fusion proteins
* We used DeepLoc 1.0. The order of the X-axis of the barplot is as follows: Entry_ID, Localization, Type, Nucleus, Cytoplasm, Extracellular, Mitochondrion, Cell_membrane, Endoplasmic_reticulum, Plastid, Golgi.apparatus, Lysosome.Vacuole, Peroxisome. Y-axis is the output score of DeepLoc. Clicking the image will open a new tab with a large image.

Hgene

Hchr

Hbp

Henst

Tgene

Tchr

Tbp

Tenst

DeepLoc result

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Related Drugs to NF1-SAFB2

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to NF1-SAFB2

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	NF1	C0027831	Neurofibromatosis 1	44	CTD_human;GENOMICS_ENGLAND;UNIPROT
Hgene	NF1	C1708353	Hereditary Paraganglioma-Pheochromocytoma Syndrome	10	CLINGEN
Hgene	NF1	C0349639	Juvenile Myelomonocytic Leukemia	7	CTD_human;GENOMICS_ENGLAND;ORPHANET
Hgene	NF1	C2931482	Neurofibromatosis-Noonan syndrome	6	CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
Hgene	NF1	C0553586	Cafe-au-lait macules with pulmonary stenosis	5	CTD_human;GENOMICS_ENGLAND;ORPHANET
Hgene	NF1	C0162678	Neurofibromatoses	3	CGI;CTD_human;GENOMICS_ENGLAND
Hgene	NF1	C0004114	Astrocytoma	2	CTD_human
Hgene	NF1	C0023467	Leukemia, Myelocytic, Acute	2	CTD_human
Hgene	NF1	C0025202	melanoma	2	CGI;CTD_human
Hgene	NF1	C0026998	Acute Myeloid Leukemia, M1	2	CTD_human
Hgene	NF1	C0205768	Subependymal Giant Cell Astrocytoma	2	CTD_human
Hgene	NF1	C0206727	Nerve Sheath Tumors	2	CTD_human
Hgene	NF1	C0280783	Juvenile Pilocytic Astrocytoma	2	CTD_human
Hgene	NF1	C0280785	Diffuse Astrocytoma	2	CTD_human
Hgene	NF1	C0334579	Anaplastic astrocytoma	2	CTD_human
Hgene	NF1	C0334580	Protoplasmic astrocytoma	2	CTD_human
Hgene	NF1	C0334581	Gemistocytic astrocytoma	2	CTD_human
Hgene	NF1	C0334582	Fibrillary Astrocytoma	2	CTD_human
Hgene	NF1	C0334583	Pilocytic Astrocytoma	2	CTD_human
Hgene	NF1	C0338070	Childhood Cerebral Astrocytoma	2	CTD_human
Hgene	NF1	C0547065	Mixed oligoastrocytoma	2	CTD_human
Hgene	NF1	C0750935	Cerebral Astrocytoma	2	CTD_human
Hgene	NF1	C0750936	Intracranial Astrocytoma	2	CTD_human
Hgene	NF1	C0751689	Peripheral Nerve Sheath Neoplasm	2	CTD_human
Hgene	NF1	C0751691	Perineurioma	2	CTD_human
Hgene	NF1	C1704230	Grade I Astrocytoma	2	CTD_human
Hgene	NF1	C1834235	NEUROFIBROMATOSIS, FAMILIAL SPINAL	2	CTD_human;GENOMICS_ENGLAND;UNIPROT
Hgene	NF1	C1879321	Acute Myeloid Leukemia (AML-M2)	2	CTD_human
Hgene	NF1	C0001430	Adenoma	1	CTD_human
Hgene	NF1	C0004352	Autistic Disorder	1	CTD_human
Hgene	NF1	C0016057	Fibrosarcoma	1	CTD_human
Hgene	NF1	C0017636	Glioblastoma	1	CTD_human
Hgene	NF1	C0017638	Glioma	1	CGI;CTD_human
Hgene	NF1	C0020796	Profound Mental Retardation	1	CTD_human
Hgene	NF1	C0023186	Learning Disorders	1	CTD_human
Hgene	NF1	C0023827	liposarcoma	1	CTD_human
Hgene	NF1	C0025363	Mental Retardation, Psychosocial	1	CTD_human
Hgene	NF1	C0026654	Moyamoya Disease	1	GENOMICS_ENGLAND
Hgene	NF1	C0027809	Neurilemmoma	1	CTD_human
Hgene	NF1	C0027830	neurofibroma	1	CTD_human
Hgene	NF1	C0027962	Melanocytic nevus	1	CTD_human
Hgene	NF1	C0028326	Noonan Syndrome	1	GENOMICS_ENGLAND
Hgene	NF1	C0031511	Pheochromocytoma	1	CTD_human
Hgene	NF1	C0035320	Retinal Neovascularization	1	CTD_human
Hgene	NF1	C0205646	Adenoma, Basal Cell	1	CTD_human
Hgene	NF1	C0205647	Follicular adenoma	1	CTD_human
Hgene	NF1	C0205648	Adenoma, Microcystic	1	CTD_human
Hgene	NF1	C0205649	Adenoma, Monomorphic	1	CTD_human
Hgene	NF1	C0205650	Papillary adenoma	1	CTD_human
Hgene	NF1	C0205651	Adenoma, Trabecular	1	CTD_human
Hgene	NF1	C0205824	Liposarcoma, Dedifferentiated	1	CTD_human
Hgene	NF1	C0205825	Liposarcoma, Pleomorphic	1	CTD_human
Hgene	NF1	C0205944	Sarcoma, Epithelioid	1	CTD_human
Hgene	NF1	C0205945	Sarcoma, Spindle Cell	1	CTD_human
Hgene	NF1	C0259783	mixed gliomas	1	CTD_human
Hgene	NF1	C0334588	Giant Cell Glioblastoma	1	CTD_human
Hgene	NF1	C0555198	Malignant Glioma	1	CTD_human
Hgene	NF1	C0751262	Adult Learning Disorders	1	CTD_human
Hgene	NF1	C0751263	Learning Disturbance	1	CTD_human
Hgene	NF1	C0751265	Learning Disabilities	1	CTD_human
Hgene	NF1	C0751374	Schwannomatosis, Plexiform	1	CTD_human
Hgene	NF1	C0917816	Mental deficiency	1	CTD_human
Hgene	NF1	C0917817	Neurofibromatosis 3	1	CTD_human
Hgene	NF1	C1257877	Pheochromocytoma, Extra-Adrenal	1	CTD_human
Hgene	NF1	C1261473	Sarcoma	1	CTD_human
Hgene	NF1	C1330966	Developmental Academic Disorder	1	CTD_human
Hgene	NF1	C1370889	Liposarcoma, well differentiated	1	CTD_human
Hgene	NF1	C1621958	Glioblastoma Multiforme	1	CTD_human
Hgene	NF1	C3150928	NF1 Microdeletion Syndrome	1	ORPHANET
Hgene	NF1	C3714756	Intellectual Disability	1	CTD_human

	Fusion Gene and Fusion Protein Summary
	Fusion Amino Acid Sequences (multiple BPs and multiple gene isoforms)
	Fusion Protein Breakpoint Sequences - (for the Screening of the FusionNeoAntigens)
	Potential FusionNeoAntigens in HLA I - (netMHCpan v4.1 + deepHLApan v1.1)
	Potential FusionNeoAntigens in HLA II - (netMHCIIpan v4.1)
	Fusion Breakpoint 14 AA Peptide Structure - (RoseTTAFold)
	Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D - (Glide)
	Vaccine Design for the FusionNeoAntigens (RNA/protein sequences)
	Potential target of CAR-T therapy development
	Information on the samples that have these potential fusion neoantigens
	Fusion Protein Targeting Drugs - (Manual Curation)
	Fusion Protein Related diseases - (Manual Curation)