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Fusion Protein:NOL10-LAP3

Fusion Gene and Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: NOL10-LAP3
	FusionPDB ID: 59521
	FusionGDB2.0 ID: 59521
		Hgene	Tgene
	Gene symbol	NOL10	LAP3
	Gene ID	79954	51056
	Gene name	nucleolar protein 10	leucine aminopeptidase 3
	Synonyms	PQBP5	HEL-S-106\|LAP\|LAPEP\|PEPS
	Cytomap	2p25.1	4p15.32
	Type of gene	protein-coding	protein-coding
	Description	nucleolar protein 10H_NH0074G24.1polyglutamine binding protein 5	cytosol aminopeptidaseLAP-3epididymis secretory protein Li 106leucyl aminopeptidasepeptidase Sproline aminopeptidaseprolyl aminopeptidase
	Modification date	20200313	20200313
	UniProtAcc	Q9BSC4 Main function of 5'-partner protein:	P28838 Main function of 5'-partner protein: FUNCTION: Cytolosic metallopeptidase that catalyzes the removal of unsubstituted N-terminal hydrophobic amino acids from various peptides. The presence of Zn(2+) ions is essential for the peptidase activity, and the association with other cofactors can modulate the substrate spectificity of the enzyme. For instance, in the presence of Mn(2+), it displays a specific Cys-Gly hydrolyzing activity of Cys-Gly-S-conjugates. Involved in the metabolism of glutathione and in the degradation of glutathione S-conjugates, which may play a role in the control of the cell redox status. {ECO:0000250\|UniProtKB:P00727}.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000345985, ENST00000381685, ENST00000538384, ENST00000542668,	ENST00000503467, ENST00000226299, ENST00000606142,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	7 X 7 X 4=196	8 X 7 X 7=392
	# samples	8	8
	** MAII score	log2(8/196*10)=-1.29278174922785 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(8/392*10)=-2.29278174922785 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Fusion gene context	PubMed: NOL10 [Title/Abstract] AND LAP3 [Title/Abstract] AND fusion [Title/Abstract]
Fusion neoantigen context	PubMed: NOL10 [Title/Abstract] AND LAP3 [Title/Abstract] AND neoantigen [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	NOL10(10784445)-LAP3(17583910), # samples:1
Anticipated loss of major functional domain due to fusion event.	NOL10-LAP3 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF. NOL10-LAP3 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:10784445/chr4:17583910)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Retention analysis results of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features, are available here.

Fusion gene breakpoints across NOL10 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across LAP3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Amino Acid Sequences

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000345985	NOL10	chr2	10784445	-	ENST00000226299	LAP3	chr4	17583910	+	2653	987	99	2273	724
ENST00000345985	NOL10	chr2	10784445	-	ENST00000606142	LAP3	chr4	17583910	+	2619	987	99	2273	724
ENST00000381685	NOL10	chr2	10784445	-	ENST00000226299	LAP3	chr4	17583910	+	2798	1132	94	2418	774
ENST00000381685	NOL10	chr2	10784445	-	ENST00000606142	LAP3	chr4	17583910	+	2764	1132	94	2418	774
ENST00000538384	NOL10	chr2	10784445	-	ENST00000226299	LAP3	chr4	17583910	+	2728	1062	102	2348	748
ENST00000538384	NOL10	chr2	10784445	-	ENST00000606142	LAP3	chr4	17583910	+	2694	1062	102	2348	748

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000345985	ENST00000226299	NOL10	chr2	10784445	-	LAP3	chr4	17583910	+	0.000892256	0.9991078
ENST00000345985	ENST00000606142	NOL10	chr2	10784445	-	LAP3	chr4	17583910	+	0.000880607	0.99911934
ENST00000381685	ENST00000226299	NOL10	chr2	10784445	-	LAP3	chr4	17583910	+	0.000706644	0.9992933
ENST00000381685	ENST00000606142	NOL10	chr2	10784445	-	LAP3	chr4	17583910	+	0.000701706	0.99929833
ENST00000538384	ENST00000226299	NOL10	chr2	10784445	-	LAP3	chr4	17583910	+	0.00096452	0.9990355
ENST00000538384	ENST00000606142	NOL10	chr2	10784445	-	LAP3	chr4	17583910	+	0.000967361	0.9990326

Predicted full-length fusion amino acid sequences. For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among all the predicted ones.

Get the fusion protein sequences from here.

Fusion protein sequence information is available in the fasta format.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

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Fusion Protein Breakpoint Sequences for NOL10-LAP3

+/-13 AA sequence from the breakpoints of the fusion protein sequences.

Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	Length(fusion protein)	BP in fusion protein	Peptide
NOL10	chr2	10784445	LAP3	chr4	17583910	1062	320	ANETPKMGIYYIPDFPSVVLVGLGKK
NOL10	chr2	10784445	LAP3	chr4	17583910	1132	346	ANETPKMGIYYIPDFPSVVLVGLGKK
NOL10	chr2	10784445	LAP3	chr4	17583910	987	296	ANETPKMGIYYIPDFPSVVLVGLGKK

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Potential FusionNeoAntigen Information of NOL10-LAP3 in HLA I

Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.

NOL10-LAP3_10784445_17583910.msa

Potential FusionNeoAntigen Information
* We used NetMHCpan v4.1 (%rank<0.5) and deepHLApan v1.1 (immunogenic score>0.5)

Fusion gene	Hchr	Hbp	Tgene	Tchr	Tbp	HLA I	FusionNeoAntigen peptide	Binding score	Immunogenic score	Neoantigen start (at BP 13)	Neoantigen end (at BP 13)
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-B51:01	IPDFPSVV	0.998	0.6924	11	19
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-B51:02	IPDFPSVV	0.9978	0.6875	11	19
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-A02:21	YIPDFPSV	0.9951	0.7464	10	18
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-B35:03	PDFPSVVL	0.9174	0.9561	12	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-B35:04	PDFPSVVL	0.7823	0.9816	12	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-B35:02	PDFPSVVL	0.7823	0.9816	12	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-A02:22	YIPDFPSVV	0.9946	0.6044	10	19
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-B35:03	IPDFPSVVL	0.9943	0.9438	11	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-B35:01	IPDFPSVVL	0.9936	0.9364	11	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-A02:24	YIPDFPSVV	0.9932	0.714	10	19
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-A02:30	YIPDFPSVV	0.9932	0.714	10	19
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-A02:21	YIPDFPSVV	0.9932	0.7885	10	19
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-A02:67	YIPDFPSVV	0.9932	0.714	10	19
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-A02:60	YIPDFPSVV	0.9932	0.7094	10	19
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-A02:11	YIPDFPSVV	0.9928	0.7254	10	19
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-B35:08	IPDFPSVVL	0.9884	0.9081	11	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-A02:29	YIPDFPSVV	0.9869	0.7171	10	19
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-A02:27	YIPDFPSVV	0.9852	0.6458	10	19
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-A02:13	YIPDFPSVV	0.9812	0.7449	10	19
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-A02:35	YIPDFPSVV	0.9801	0.7478	10	19
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-A02:20	YIPDFPSVV	0.9786	0.7196	10	19
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-B35:04	IPDFPSVVL	0.9768	0.9749	11	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-B35:02	IPDFPSVVL	0.9768	0.9749	11	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-B15:10	IPDFPSVVL	0.9718	0.6904	11	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-B39:24	IPDFPSVVL	0.9629	0.5416	11	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-A02:16	YIPDFPSVV	0.9595	0.6278	10	19
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-B15:37	IPDFPSVVL	0.9593	0.7376	11	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-B35:05	IPDFPSVVL	0.9592	0.7018	11	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-A02:38	YIPDFPSVV	0.9536	0.6795	10	19
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-A02:04	YIPDFPSVV	0.946	0.7685	10	19
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-B39:01	IPDFPSVVL	0.9391	0.968	11	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-B14:02	IPDFPSVVL	0.9375	0.8538	11	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-B14:01	IPDFPSVVL	0.9375	0.8538	11	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-A02:17	YIPDFPSVV	0.9241	0.6923	10	19
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-A02:19	YIPDFPSVV	0.9103	0.545	10	19
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-A02:21	YYIPDFPSV	0.8303	0.7157	9	18
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-B52:01	YYIPDFPSV	0.4798	0.9055	9	18
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-B08:01	IPDFPSVVL	0.3118	0.7762	11	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-B08:09	IPDFPSVVL	0.2307	0.8223	11	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-B51:01	IPDFPSVVLV	0.9848	0.5935	11	21
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-B51:02	IPDFPSVVLV	0.9825	0.5633	11	21
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-B35:04	IPDFPSVVLV	0.9706	0.963	11	21
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-B35:02	IPDFPSVVLV	0.9706	0.963	11	21
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-B35:03	IPDFPSVVLV	0.9527	0.9369	11	21
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-B35:08	YIPDFPSVVL	0.9219	0.8326	10	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-B35:03	YIPDFPSVVL	0.9022	0.914	10	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-B35:01	YIPDFPSVVL	0.8675	0.916	10	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-B35:04	YIPDFPSVVL	0.8675	0.9638	10	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-B35:02	YIPDFPSVVL	0.8675	0.9638	10	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-A02:21	YIPDFPSVVLV	0.996	0.5778	10	21
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-A02:11	YIPDFPSVVLV	0.9943	0.5127	10	21
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-A02:21	GIYYIPDFPSV	0.994	0.7289	7	18
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-B35:03	YYIPDFPSVVL	0.9861	0.8883	9	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-B35:08	YYIPDFPSVVL	0.9824	0.7934	9	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-A02:17	YIPDFPSVVLV	0.9766	0.5527	10	21
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-A02:35	YIPDFPSVVLV	0.9737	0.5085	10	21
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-B35:02	YYIPDFPSVVL	0.9706	0.9484	9	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-B35:04	YYIPDFPSVVL	0.9706	0.9484	9	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-A02:29	GIYYIPDFPSV	0.9659	0.6376	7	18
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-A02:35	GIYYIPDFPSV	0.9644	0.6737	7	18
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-A02:20	GIYYIPDFPSV	0.9596	0.6377	7	18
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-A02:07	YIPDFPSV	0.9957	0.7114	10	18
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-B78:01	IPDFPSVV	0.9949	0.7594	11	19
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-B51:08	IPDFPSVV	0.991	0.7384	11	19
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C01:17	YIPDFPSV	0.9869	0.9402	10	18
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C01:30	YIPDFPSV	0.9672	0.9697	10	18
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-B39:10	PDFPSVVL	0.8458	0.9794	12	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-B35:12	PDFPSVVL	0.7823	0.9816	12	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-B39:10	IPDFPSVV	0.7565	0.9838	11	19
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C05:09	IPDFPSVVL	0.999	0.9672	11	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C04:07	IPDFPSVVL	0.9989	0.8683	11	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C04:10	IPDFPSVVL	0.9988	0.8767	11	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C08:15	IPDFPSVVL	0.998	0.9814	11	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C12:04	YIPDFPSVV	0.9972	0.9942	10	19
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C06:03	YIPDFPSVV	0.9966	0.9945	10	19
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C03:19	IPDFPSVVL	0.9957	0.9927	11	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C01:17	IPDFPSVVL	0.9954	0.9681	11	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C03:08	IPDFPSVVL	0.9951	0.9337	11	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-A02:07	YIPDFPSVV	0.9935	0.7563	10	19
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-A02:01	YIPDFPSVV	0.9932	0.714	10	19
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C01:30	IPDFPSVVL	0.9927	0.9772	11	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C04:06	YIPDFPSVV	0.9919	0.9583	10	19
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C12:12	YIPDFPSVV	0.9919	0.948	10	19
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C03:07	YIPDFPSVV	0.9894	0.9904	10	19
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C05:09	YIPDFPSVV	0.987	0.9732	10	19
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C15:06	YIPDFPSVV	0.9793	0.9627	10	19
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-B07:12	IPDFPSVVL	0.9774	0.6735	11	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-B35:12	IPDFPSVVL	0.9768	0.9749	11	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-B14:03	IPDFPSVVL	0.9723	0.9354	11	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C08:04	IPDFPSVVL	0.9689	0.9785	11	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C08:13	IPDFPSVVL	0.9689	0.9785	11	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C03:19	YIPDFPSVV	0.9679	0.9944	10	19
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C04:06	IPDFPSVVL	0.9617	0.966	11	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-B39:09	IPDFPSVVL	0.9551	0.6305	11	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C08:03	IPDFPSVVL	0.9533	0.9915	11	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C04:10	YIPDFPSVV	0.9498	0.8609	10	19
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-B39:10	IPDFPSVVL	0.9407	0.9653	11	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C04:07	YIPDFPSVV	0.9374	0.8495	10	19
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C08:04	YIPDFPSVV	0.9356	0.9825	10	19
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C08:13	YIPDFPSVV	0.9356	0.9825	10	19
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-B51:07	IPDFPSVVL	0.9322	0.9466	11	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-B39:08	IPDFPSVVL	0.9317	0.8978	11	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C08:15	YIPDFPSVV	0.9301	0.9828	10	19
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C04:14	YIPDFPSVV	0.9225	0.8992	10	19
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-B39:12	IPDFPSVVL	0.9223	0.9715	11	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-B78:01	IPDFPSVVL	0.9143	0.6318	11	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C07:13	IPDFPSVVL	0.9032	0.972	11	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C01:17	YIPDFPSVV	0.8753	0.9473	10	19
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C07:29	IPDFPSVVL	0.851	0.9643	11	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C12:16	YIPDFPSVV	0.8503	0.9765	10	19
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-B39:05	IPDFPSVVL	0.8178	0.9633	11	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-A02:07	YYIPDFPSV	0.7768	0.6699	9	18
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C01:30	YIPDFPSVV	0.7272	0.9741	10	19
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C04:14	IPDFPSVVL	0.7153	0.9021	11	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C08:03	YIPDFPSVV	0.6626	0.9881	10	19
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-B51:08	IPDFPSVVL	0.6569	0.5324	11	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C07:05	YYIPDFPSV	0.509	0.9631	9	18
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C02:06	YIPDFPSVV	0.4992	0.9848	10	19
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C07:29	YYIPDFPSV	0.4868	0.9463	9	18
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-B42:02	IPDFPSVVL	0.4738	0.7639	11	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C04:14	YYIPDFPSV	0.4563	0.8389	9	18
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-B51:07	YYIPDFPSV	0.4528	0.8748	9	18
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-B39:09	YYIPDFPSV	0.434	0.5477	9	18
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-B42:01	IPDFPSVVL	0.4184	0.7582	11	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C07:13	YYIPDFPSV	0.4154	0.9333	9	18
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C07:46	YYIPDFPSV	0.3849	0.8802	9	18
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C07:10	YYIPDFPSV	0.374	0.9573	9	18
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C07:80	YYIPDFPSV	0.3708	0.943	9	18
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C07:67	YYIPDFPSV	0.3708	0.943	9	18
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-B39:12	YYIPDFPSV	0.3484	0.9033	9	18
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C07:19	YYIPDFPSV	0.3235	0.7513	9	18
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C07:80	YIPDFPSVV	0.2399	0.9732	10	19
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C07:67	YIPDFPSVV	0.2399	0.9732	10	19
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C12:16	YYIPDFPSV	0.2182	0.9515	9	18
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C07:19	YIPDFPSVV	0.2125	0.8322	10	19
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C04:07	YYIPDFPSV	0.2097	0.7581	9	18
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C04:10	YYIPDFPSV	0.2034	0.7644	9	18
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C07:10	YIPDFPSVV	0.1974	0.9789	10	19
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C07:95	YYIPDFPSV	0.1941	0.7707	9	18
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C07:27	YYIPDFPSV	0.181	0.9525	9	18
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C07:13	YIPDFPSVV	0.0846	0.9626	10	19
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C07:29	YIPDFPSVV	0.0712	0.9669	10	19
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C07:27	YIPDFPSVV	0.0552	0.9718	10	19
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C05:09	YIPDFPSVVL	0.9987	0.9486	10	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C04:10	YIPDFPSVVL	0.9978	0.7953	10	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C04:07	YIPDFPSVVL	0.9974	0.7857	10	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C08:15	YIPDFPSVVL	0.9971	0.9635	10	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C04:06	YIPDFPSVVL	0.9948	0.9103	10	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C01:17	YIPDFPSVVL	0.9934	0.9421	10	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-B54:01	IPDFPSVVLV	0.9932	0.5016	11	21
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C04:14	YIPDFPSVVL	0.9932	0.8069	10	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-B78:01	IPDFPSVVLV	0.9903	0.7526	11	21
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C08:04	YIPDFPSVVL	0.9895	0.9619	10	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C08:13	YIPDFPSVVL	0.9895	0.9619	10	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C01:30	YIPDFPSVVL	0.9889	0.961	10	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-B51:07	IPDFPSVVLV	0.9788	0.9679	11	21
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-A02:07	YIPDFPSVVL	0.9769	0.5227	10	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-B35:12	IPDFPSVVLV	0.9706	0.963	11	21
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C08:03	YIPDFPSVVL	0.9516	0.9811	10	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C07:29	YIPDFPSVVL	0.942	0.946	10	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C07:13	YIPDFPSVVL	0.9375	0.9499	10	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-B51:08	IPDFPSVVLV	0.9298	0.612	11	21
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-B07:12	YIPDFPSVVL	0.874	0.5727	10	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-B35:12	YIPDFPSVVL	0.8675	0.9638	10	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-B42:02	YIPDFPSVVL	0.8596	0.5363	10	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-B39:09	YIPDFPSVVL	0.8578	0.5698	10	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C04:14	YYIPDFPSVV	0.8523	0.8835	9	19
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-B39:10	YIPDFPSVVL	0.8274	0.9213	10	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-B42:01	YIPDFPSVVL	0.8172	0.532	10	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C07:29	YYIPDFPSVV	0.6715	0.9467	9	19
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C01:17	YYIPDFPSVV	0.6627	0.9163	9	19
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C01:30	YYIPDFPSVV	0.6622	0.9562	9	19
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-B39:10	IPDFPSVVLV	0.6442	0.9303	11	21
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-A02:07	YYIPDFPSVV	0.6329	0.6713	9	19
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C07:13	YYIPDFPSVV	0.5858	0.9427	9	19
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C04:10	YYIPDFPSVVL	0.998	0.7972	9	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C04:07	YYIPDFPSVVL	0.9979	0.7804	9	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C01:17	YYIPDFPSVVL	0.9974	0.9339	9	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C07:05	YYIPDFPSVVL	0.9968	0.9522	9	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C04:14	YYIPDFPSVVL	0.9934	0.8022	9	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C07:29	YYIPDFPSVVL	0.9932	0.9364	9	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C07:10	YYIPDFPSVVL	0.9931	0.9433	9	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C07:27	YYIPDFPSVVL	0.9926	0.9523	9	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C07:67	YYIPDFPSVVL	0.9924	0.9425	9	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C07:80	YYIPDFPSVVL	0.9924	0.9425	9	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C07:13	YYIPDFPSVVL	0.9914	0.9273	9	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C01:30	YYIPDFPSVVL	0.9896	0.9399	9	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-B39:10	YYIPDFPSVVL	0.9886	0.8835	9	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-B39:09	YYIPDFPSVVL	0.9883	0.5286	9	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C07:19	YYIPDFPSVVL	0.9879	0.6551	9	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C07:46	YYIPDFPSVVL	0.9801	0.8609	9	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-B35:12	YYIPDFPSVVL	0.9706	0.9484	9	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C01:17	YIPDFPSVVLV	0.9479	0.9146	10	21
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-B07:12	YYIPDFPSVVL	0.9308	0.5613	9	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-B51:14	IPDFPSVV	0.9982	0.6955	11	19
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-B78:02	IPDFPSVV	0.9981	0.9127	11	19
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-B51:13	IPDFPSVV	0.9978	0.6741	11	19
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-B51:29	IPDFPSVV	0.9973	0.628	11	19
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-B51:21	IPDFPSVV	0.9954	0.7089	11	19
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-A02:06	YIPDFPSV	0.9951	0.7464	10	18
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-B51:09	IPDFPSVV	0.9945	0.731	11	19
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C01:03	YIPDFPSV	0.9915	0.9545	10	18
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C01:02	YIPDFPSV	0.9867	0.9356	10	18
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-B59:01	IPDFPSVV	0.9486	0.5852	11	19
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-B67:01	PDFPSVVL	0.8378	0.9428	12	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-B35:09	PDFPSVVL	0.7823	0.9816	12	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C05:01	IPDFPSVVL	0.999	0.9672	11	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C04:03	IPDFPSVVL	0.9989	0.8854	11	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C04:01	IPDFPSVVL	0.9989	0.8683	11	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C01:03	IPDFPSVVL	0.9983	0.9315	11	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C08:02	IPDFPSVVL	0.998	0.9814	11	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C03:03	IPDFPSVVL	0.9978	0.9915	11	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C18:01	IPDFPSVVL	0.9978	0.8765	11	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C03:04	IPDFPSVVL	0.9978	0.9915	11	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C03:05	IPDFPSVVL	0.9969	0.965	11	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C03:67	IPDFPSVVL	0.9965	0.9826	11	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-A02:03	YIPDFPSVV	0.9951	0.7543	10	19
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-B35:77	IPDFPSVVL	0.9936	0.9364	11	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C12:03	YIPDFPSVV	0.9936	0.9832	10	19
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-B35:13	IPDFPSVVL	0.9936	0.9466	11	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-A02:14	YIPDFPSVV	0.9933	0.7025	10	19
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-A02:06	YIPDFPSVV	0.9932	0.7885	10	19
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-B35:23	IPDFPSVVL	0.9927	0.9419	11	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-B07:13	IPDFPSVVL	0.9891	0.882	11	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-B35:20	IPDFPSVVL	0.9876	0.9554	11	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C05:01	YIPDFPSVV	0.987	0.9732	10	19
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C04:03	YIPDFPSVV	0.9846	0.8631	10	19
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C15:05	YIPDFPSVV	0.9817	0.9738	10	19
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C15:02	YIPDFPSVV	0.978	0.9583	10	19
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-B35:09	IPDFPSVVL	0.9768	0.9749	11	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C03:17	YIPDFPSVV	0.969	0.98	10	19
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C03:05	YIPDFPSVV	0.9684	0.9651	10	19
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C12:02	YIPDFPSVV	0.9682	0.9778	10	19
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-B35:24	IPDFPSVVL	0.9638	0.9586	11	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-B35:30	IPDFPSVVL	0.9613	0.8427	11	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-B35:17	IPDFPSVVL	0.9613	0.8427	11	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C03:06	YIPDFPSVV	0.9602	0.994	10	19
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-B35:11	IPDFPSVVL	0.9599	0.9122	11	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C01:03	YIPDFPSVV	0.9593	0.9621	10	19
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C18:01	YIPDFPSVV	0.9583	0.8459	10	19
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C06:17	YIPDFPSVV	0.9553	0.9941	10	19
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C06:02	YIPDFPSVV	0.9553	0.9941	10	19
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C08:01	IPDFPSVVL	0.9533	0.9915	11	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-A68:02	YIPDFPSVV	0.9484	0.718	10	19
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C03:06	IPDFPSVVL	0.9467	0.9918	11	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-B67:01	IPDFPSVVL	0.9448	0.9052	11	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-B39:02	IPDFPSVVL	0.9427	0.9795	11	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C04:04	IPDFPSVVL	0.942	0.9457	11	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-B39:31	IPDFPSVVL	0.9399	0.969	11	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C04:01	YIPDFPSVV	0.9374	0.8495	10	19
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-B78:02	IPDFPSVVL	0.9371	0.7186	11	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-B39:11	IPDFPSVVL	0.9317	0.8756	11	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C03:04	YIPDFPSVV	0.9307	0.9934	10	19
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C03:03	YIPDFPSVV	0.9307	0.9934	10	19
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C08:02	YIPDFPSVV	0.9301	0.9828	10	19
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-B53:02	IPDFPSVVL	0.908	0.5226	11	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C01:02	YIPDFPSVV	0.8994	0.9426	10	19
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-A69:01	YIPDFPSVV	0.8973	0.9051	10	19
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C16:04	YIPDFPSVV	0.8964	0.9795	10	19
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-B15:09	IPDFPSVVL	0.883	0.7633	11	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C04:04	YIPDFPSVV	0.873	0.9515	10	19
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C06:06	YIPDFPSVV	0.8693	0.9749	10	19
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-B51:21	IPDFPSVVL	0.8599	0.5486	11	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-A02:06	YYIPDFPSV	0.8303	0.7157	9	18
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-A02:14	YYIPDFPSV	0.8294	0.5895	9	18
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C03:67	YIPDFPSVV	0.8106	0.9883	10	19
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C07:04	IPDFPSVVL	0.8089	0.9579	11	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C08:01	YIPDFPSVV	0.6626	0.9881	10	19
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C04:04	YYIPDFPSV	0.607	0.9031	9	18
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-B08:12	IPDFPSVVL	0.5237	0.8713	11	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C03:67	YYIPDFPSV	0.4911	0.9841	9	18
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C06:17	YYIPDFPSV	0.4658	0.9888	9	18
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C06:02	YYIPDFPSV	0.4658	0.9888	9	18
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C02:02	YIPDFPSVV	0.3886	0.9834	10	19
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C02:10	YIPDFPSVV	0.3886	0.9834	10	19
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C17:01	YIPDFPSVV	0.3736	0.9583	10	19
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C07:02	YYIPDFPSV	0.3708	0.943	9	18
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C07:17	YYIPDFPSV	0.336	0.9652	9	18
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-B18:07	IPDFPSVVL	0.3303	0.9545	11	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-B08:18	IPDFPSVVL	0.3118	0.7762	11	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C06:08	YIPDFPSVV	0.2763	0.989	10	19
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-B15:09	YYIPDFPSV	0.2631	0.6779	9	18
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-B07:13	YIPDFPSVV	0.2593	0.8641	10	19
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C06:06	YYIPDFPSV	0.2566	0.9684	9	18
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C07:04	YYIPDFPSV	0.2553	0.8922	9	18
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C07:02	YIPDFPSVV	0.2399	0.9732	10	19
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C07:04	YIPDFPSVV	0.2334	0.9591	10	19
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C07:22	YYIPDFPSV	0.2258	0.7403	9	18
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C04:01	YYIPDFPSV	0.2097	0.7581	9	18
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C18:01	YYIPDFPSV	0.1997	0.7618	9	18
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C06:08	YYIPDFPSV	0.189	0.9847	9	18
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C14:02	YYIPDFPSV	0.1538	0.936	9	18
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C14:03	YYIPDFPSV	0.1538	0.936	9	18
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C07:01	YYIPDFPSV	0.1416	0.7262	9	18
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C07:22	YIPDFPSVV	0.1193	0.8526	10	19
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C07:17	YIPDFPSVV	0.0944	0.9821	10	19
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-B35:43	IPDFPSVVL	0.0236	0.8564	11	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-B15:08	IPDFPSVVL	0.0185	0.8586	11	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-B15:11	IPDFPSVVL	0.0156	0.8681	11	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C03:03	YIPDFPSVVL	0.999	0.9907	10	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C03:04	YIPDFPSVVL	0.999	0.9907	10	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C05:01	YIPDFPSVVL	0.9987	0.9486	10	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C04:03	YIPDFPSVVL	0.9985	0.8144	10	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C18:01	YIPDFPSVVL	0.9977	0.7928	10	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C04:01	YIPDFPSVVL	0.9974	0.7857	10	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C01:03	YIPDFPSVVL	0.9972	0.8792	10	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C08:02	YIPDFPSVVL	0.9971	0.9635	10	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C01:02	YIPDFPSVVL	0.9944	0.9395	10	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C03:06	YIPDFPSVVL	0.993	0.9909	10	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-B78:02	IPDFPSVVLV	0.9891	0.8723	11	21
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-B51:14	IPDFPSVVLV	0.9877	0.5494	11	21
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-B51:13	IPDFPSVVLV	0.983	0.5922	11	21
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-B51:09	IPDFPSVVLV	0.9827	0.5841	11	21
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-B51:06	IPDFPSVVLV	0.9803	0.5636	11	21
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-B51:21	IPDFPSVVLV	0.9766	0.6229	11	21
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-B35:09	IPDFPSVVLV	0.9706	0.963	11	21
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-B51:29	IPDFPSVVLV	0.9604	0.5691	11	21
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C08:01	YIPDFPSVVL	0.9516	0.9811	10	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-B56:05	IPDFPSVVLV	0.95	0.5525	11	21
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C17:01	YIPDFPSVVL	0.9034	0.9226	10	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-B07:13	YIPDFPSVVL	0.8983	0.8405	10	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-B35:13	YIPDFPSVVL	0.8813	0.9165	10	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-B35:23	YIPDFPSVVL	0.8707	0.9285	10	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-B35:77	YIPDFPSVVL	0.8675	0.916	10	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-B35:09	YIPDFPSVVL	0.8675	0.9638	10	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-B67:01	YIPDFPSVVL	0.8389	0.8417	10	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C04:04	YYIPDFPSVV	0.8344	0.9237	9	19
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C06:06	YYIPDFPSVV	0.8249	0.9555	9	19
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-B67:01	IPDFPSVVLV	0.714	0.8522	11	21
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C01:03	YYIPDFPSVV	0.6927	0.9426	9	19
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C14:02	YYIPDFPSVV	0.6515	0.9317	9	19
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C14:03	YYIPDFPSVV	0.6515	0.9317	9	19
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C01:02	YYIPDFPSVV	0.6456	0.9103	9	19
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C14:03	YYIPDFPSVVL	0.9984	0.9484	9	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C14:02	YYIPDFPSVVL	0.9984	0.9484	9	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C04:03	YYIPDFPSVVL	0.9981	0.8153	9	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C01:03	YYIPDFPSVVL	0.9981	0.881	9	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C18:01	YYIPDFPSVVL	0.998	0.7945	9	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C04:01	YYIPDFPSVVL	0.9979	0.7804	9	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C01:02	YYIPDFPSVVL	0.9972	0.932	9	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-A02:06	YIPDFPSVVLV	0.996	0.5778	10	21
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C03:67	YYIPDFPSVVL	0.9954	0.9765	9	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-A02:14	GIYYIPDFPSV	0.9945	0.5994	7	18
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C04:04	YYIPDFPSVVL	0.9941	0.8422	9	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-A02:06	GIYYIPDFPSV	0.994	0.7289	7	18
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C07:17	YYIPDFPSVVL	0.9927	0.964	9	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C07:02	YYIPDFPSVVL	0.9924	0.9425	9	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-B67:01	YYIPDFPSVVL	0.9903	0.7921	9	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C07:04	YYIPDFPSVVL	0.9877	0.8798	9	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C01:03	YIPDFPSVVLV	0.9847	0.8295	10	21
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-B35:13	YYIPDFPSVVL	0.9824	0.891	9	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-B35:09	YYIPDFPSVVL	0.9706	0.9484	9	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	HLA-C01:02	YIPDFPSVVLV	0.9563	0.9121	10	21

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Potential FusionNeoAntigen Information of NOL10-LAP3 in HLA II

NOL10-LAP3_10784445_17583910.msa

Potential FusionNeoAntigen Information
* We used NetMHCIIpan v4.1 (%rank<0.5).

Fusion gene	Hchr	Hbp	Tgene	Tchr	Tbp	HLA II	FusionNeoAntigen peptide	Neoantigen start (at BP 13)	Neoantigen end (at BP 13)
NOL10-LAP3	chr2	10784445	chr4	17583910	987	DRB1-0403	PKMGIYYIPDFPSVV	4	19
NOL10-LAP3	chr2	10784445	chr4	17583910	987	DRB1-0403	KMGIYYIPDFPSVVL	5	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	DRB1-0403	TPKMGIYYIPDFPSV	3	18
NOL10-LAP3	chr2	10784445	chr4	17583910	987	DRB1-0411	PKMGIYYIPDFPSVV	4	19
NOL10-LAP3	chr2	10784445	chr4	17583910	987	DRB1-0413	PKMGIYYIPDFPSVV	4	19
NOL10-LAP3	chr2	10784445	chr4	17583910	987	DRB1-0413	KMGIYYIPDFPSVVL	5	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	DRB1-0413	TPKMGIYYIPDFPSV	3	18
NOL10-LAP3	chr2	10784445	chr4	17583910	987	DRB1-0415	PKMGIYYIPDFPSVV	4	19
NOL10-LAP3	chr2	10784445	chr4	17583910	987	DRB1-0415	KMGIYYIPDFPSVVL	5	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	DRB1-0415	TPKMGIYYIPDFPSV	3	18
NOL10-LAP3	chr2	10784445	chr4	17583910	987	DRB1-0419	PKMGIYYIPDFPSVV	4	19
NOL10-LAP3	chr2	10784445	chr4	17583910	987	DRB1-0419	KMGIYYIPDFPSVVL	5	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	DRB1-0427	PKMGIYYIPDFPSVV	4	19
NOL10-LAP3	chr2	10784445	chr4	17583910	987	DRB1-0427	KMGIYYIPDFPSVVL	5	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	DRB1-0427	TPKMGIYYIPDFPSV	3	18
NOL10-LAP3	chr2	10784445	chr4	17583910	987	DRB1-0436	PKMGIYYIPDFPSVV	4	19
NOL10-LAP3	chr2	10784445	chr4	17583910	987	DRB1-0436	KMGIYYIPDFPSVVL	5	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	DRB1-0436	TPKMGIYYIPDFPSV	3	18
NOL10-LAP3	chr2	10784445	chr4	17583910	987	DRB1-0437	PKMGIYYIPDFPSVV	4	19
NOL10-LAP3	chr2	10784445	chr4	17583910	987	DRB1-0437	KMGIYYIPDFPSVVL	5	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	DRB1-0437	TPKMGIYYIPDFPSV	3	18
NOL10-LAP3	chr2	10784445	chr4	17583910	987	DRB1-0439	PKMGIYYIPDFPSVV	4	19
NOL10-LAP3	chr2	10784445	chr4	17583910	987	DRB1-0439	KMGIYYIPDFPSVVL	5	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	DRB1-0439	TPKMGIYYIPDFPSV	3	18
NOL10-LAP3	chr2	10784445	chr4	17583910	987	DRB1-0440	PKMGIYYIPDFPSVV	4	19
NOL10-LAP3	chr2	10784445	chr4	17583910	987	DRB1-0440	KMGIYYIPDFPSVVL	5	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	DRB1-0440	TPKMGIYYIPDFPSV	3	18
NOL10-LAP3	chr2	10784445	chr4	17583910	987	DRB1-0441	PKMGIYYIPDFPSVV	4	19
NOL10-LAP3	chr2	10784445	chr4	17583910	987	DRB1-0441	KMGIYYIPDFPSVVL	5	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	DRB1-0441	TPKMGIYYIPDFPSV	3	18
NOL10-LAP3	chr2	10784445	chr4	17583910	987	DRB1-0442	PKMGIYYIPDFPSVV	4	19
NOL10-LAP3	chr2	10784445	chr4	17583910	987	DRB1-0442	KMGIYYIPDFPSVVL	5	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	DRB1-0442	TPKMGIYYIPDFPSV	3	18
NOL10-LAP3	chr2	10784445	chr4	17583910	987	DRB1-0443	PKMGIYYIPDFPSVV	4	19
NOL10-LAP3	chr2	10784445	chr4	17583910	987	DRB1-0443	KMGIYYIPDFPSVVL	5	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	DRB1-0444	PKMGIYYIPDFPSVV	4	19
NOL10-LAP3	chr2	10784445	chr4	17583910	987	DRB1-0444	KMGIYYIPDFPSVVL	5	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	DRB1-0444	TPKMGIYYIPDFPSV	3	18
NOL10-LAP3	chr2	10784445	chr4	17583910	987	DRB1-0446	PKMGIYYIPDFPSVV	4	19
NOL10-LAP3	chr2	10784445	chr4	17583910	987	DRB1-0446	KMGIYYIPDFPSVVL	5	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	DRB1-0446	TPKMGIYYIPDFPSV	3	18
NOL10-LAP3	chr2	10784445	chr4	17583910	987	DRB1-0449	PKMGIYYIPDFPSVV	4	19
NOL10-LAP3	chr2	10784445	chr4	17583910	987	DRB1-0449	KMGIYYIPDFPSVVL	5	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	DRB1-0449	TPKMGIYYIPDFPSV	3	18
NOL10-LAP3	chr2	10784445	chr4	17583910	987	DRB1-0450	PKMGIYYIPDFPSVV	4	19
NOL10-LAP3	chr2	10784445	chr4	17583910	987	DRB1-0450	KMGIYYIPDFPSVVL	5	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	DRB1-0450	TPKMGIYYIPDFPSV	3	18
NOL10-LAP3	chr2	10784445	chr4	17583910	987	DRB1-0451	PKMGIYYIPDFPSVV	4	19
NOL10-LAP3	chr2	10784445	chr4	17583910	987	DRB1-0451	KMGIYYIPDFPSVVL	5	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	DRB1-0451	TPKMGIYYIPDFPSV	3	18
NOL10-LAP3	chr2	10784445	chr4	17583910	987	DRB1-0452	PKMGIYYIPDFPSVV	4	19
NOL10-LAP3	chr2	10784445	chr4	17583910	987	DRB1-0452	KMGIYYIPDFPSVVL	5	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	DRB1-0452	TPKMGIYYIPDFPSV	3	18
NOL10-LAP3	chr2	10784445	chr4	17583910	987	DRB1-0453	PKMGIYYIPDFPSVV	4	19
NOL10-LAP3	chr2	10784445	chr4	17583910	987	DRB1-0453	KMGIYYIPDFPSVVL	5	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	DRB1-0453	TPKMGIYYIPDFPSV	3	18
NOL10-LAP3	chr2	10784445	chr4	17583910	987	DRB1-0455	PKMGIYYIPDFPSVV	4	19
NOL10-LAP3	chr2	10784445	chr4	17583910	987	DRB1-0455	KMGIYYIPDFPSVVL	5	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	DRB1-0455	TPKMGIYYIPDFPSV	3	18
NOL10-LAP3	chr2	10784445	chr4	17583910	987	DRB1-0456	PKMGIYYIPDFPSVV	4	19
NOL10-LAP3	chr2	10784445	chr4	17583910	987	DRB1-0456	KMGIYYIPDFPSVVL	5	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	DRB1-0456	TPKMGIYYIPDFPSV	3	18
NOL10-LAP3	chr2	10784445	chr4	17583910	987	DRB1-0458	PKMGIYYIPDFPSVV	4	19
NOL10-LAP3	chr2	10784445	chr4	17583910	987	DRB1-0458	KMGIYYIPDFPSVVL	5	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	DRB1-0458	TPKMGIYYIPDFPSV	3	18
NOL10-LAP3	chr2	10784445	chr4	17583910	987	DRB1-0459	PKMGIYYIPDFPSVV	4	19
NOL10-LAP3	chr2	10784445	chr4	17583910	987	DRB1-0459	KMGIYYIPDFPSVVL	5	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	DRB1-0459	TPKMGIYYIPDFPSV	3	18
NOL10-LAP3	chr2	10784445	chr4	17583910	987	DRB1-0460	PKMGIYYIPDFPSVV	4	19
NOL10-LAP3	chr2	10784445	chr4	17583910	987	DRB1-0460	KMGIYYIPDFPSVVL	5	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	DRB1-0460	TPKMGIYYIPDFPSV	3	18
NOL10-LAP3	chr2	10784445	chr4	17583910	987	DRB1-0461	PKMGIYYIPDFPSVV	4	19
NOL10-LAP3	chr2	10784445	chr4	17583910	987	DRB1-0461	KMGIYYIPDFPSVVL	5	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	DRB1-0465	PKMGIYYIPDFPSVV	4	19
NOL10-LAP3	chr2	10784445	chr4	17583910	987	DRB1-0465	KMGIYYIPDFPSVVL	5	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	DRB1-0465	TPKMGIYYIPDFPSV	3	18
NOL10-LAP3	chr2	10784445	chr4	17583910	987	DRB1-0467	PKMGIYYIPDFPSVV	4	19
NOL10-LAP3	chr2	10784445	chr4	17583910	987	DRB1-0468	PKMGIYYIPDFPSVV	4	19
NOL10-LAP3	chr2	10784445	chr4	17583910	987	DRB1-0468	KMGIYYIPDFPSVVL	5	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	DRB1-0468	TPKMGIYYIPDFPSV	3	18
NOL10-LAP3	chr2	10784445	chr4	17583910	987	DRB1-0470	PKMGIYYIPDFPSVV	4	19
NOL10-LAP3	chr2	10784445	chr4	17583910	987	DRB1-0470	KMGIYYIPDFPSVVL	5	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	DRB1-0470	TPKMGIYYIPDFPSV	3	18
NOL10-LAP3	chr2	10784445	chr4	17583910	987	DRB1-0471	PKMGIYYIPDFPSVV	4	19
NOL10-LAP3	chr2	10784445	chr4	17583910	987	DRB1-0471	KMGIYYIPDFPSVVL	5	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	DRB1-0471	TPKMGIYYIPDFPSV	3	18
NOL10-LAP3	chr2	10784445	chr4	17583910	987	DRB1-0473	PKMGIYYIPDFPSVV	4	19
NOL10-LAP3	chr2	10784445	chr4	17583910	987	DRB1-0473	KMGIYYIPDFPSVVL	5	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	DRB1-0473	TPKMGIYYIPDFPSV	3	18
NOL10-LAP3	chr2	10784445	chr4	17583910	987	DRB1-0475	PKMGIYYIPDFPSVV	4	19
NOL10-LAP3	chr2	10784445	chr4	17583910	987	DRB1-0475	KMGIYYIPDFPSVVL	5	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	DRB1-0478	PKMGIYYIPDFPSVV	4	19
NOL10-LAP3	chr2	10784445	chr4	17583910	987	DRB1-0478	KMGIYYIPDFPSVVL	5	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	DRB1-0478	TPKMGIYYIPDFPSV	3	18
NOL10-LAP3	chr2	10784445	chr4	17583910	987	DRB1-0479	PKMGIYYIPDFPSVV	4	19
NOL10-LAP3	chr2	10784445	chr4	17583910	987	DRB1-0479	KMGIYYIPDFPSVVL	5	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	DRB1-0479	TPKMGIYYIPDFPSV	3	18
NOL10-LAP3	chr2	10784445	chr4	17583910	987	DRB1-0485	PKMGIYYIPDFPSVV	4	19
NOL10-LAP3	chr2	10784445	chr4	17583910	987	DRB1-0485	KMGIYYIPDFPSVVL	5	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	DRB1-0485	TPKMGIYYIPDFPSV	3	18
NOL10-LAP3	chr2	10784445	chr4	17583910	987	DRB1-0488	PKMGIYYIPDFPSVV	4	19
NOL10-LAP3	chr2	10784445	chr4	17583910	987	DRB1-0488	KMGIYYIPDFPSVVL	5	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	DRB1-0488	TPKMGIYYIPDFPSV	3	18
NOL10-LAP3	chr2	10784445	chr4	17583910	987	DRB1-0491	PKMGIYYIPDFPSVV	4	19
NOL10-LAP3	chr2	10784445	chr4	17583910	987	DRB1-1410	PKMGIYYIPDFPSVV	4	19
NOL10-LAP3	chr2	10784445	chr4	17583910	987	DRB1-1457	PKMGIYYIPDFPSVV	4	19
NOL10-LAP3	chr2	10784445	chr4	17583910	987	DRB1-1457	KMGIYYIPDFPSVVL	5	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	DRB1-1457	TPKMGIYYIPDFPSV	3	18
NOL10-LAP3	chr2	10784445	chr4	17583910	987	DRB1-1504	PKMGIYYIPDFPSVV	4	19
NOL10-LAP3	chr2	10784445	chr4	17583910	987	DRB1-1507	PKMGIYYIPDFPSVV	4	19
NOL10-LAP3	chr2	10784445	chr4	17583910	987	DRB1-1548	PKMGIYYIPDFPSVV	4	19
NOL10-LAP3	chr2	10784445	chr4	17583910	987	DRB1-1615	PKMGIYYIPDFPSVV	4	19
NOL10-LAP3	chr2	10784445	chr4	17583910	987	DRB1-1615	KMGIYYIPDFPSVVL	5	20
NOL10-LAP3	chr2	10784445	chr4	17583910	987	DRB3-0101	GIYYIPDFPSVVLVG	7	22
NOL10-LAP3	chr2	10784445	chr4	17583910	987	DRB3-0101	MGIYYIPDFPSVVLV	6	21
NOL10-LAP3	chr2	10784445	chr4	17583910	987	DRB3-0104	GIYYIPDFPSVVLVG	7	22
NOL10-LAP3	chr2	10784445	chr4	17583910	987	DRB3-0104	MGIYYIPDFPSVVLV	6	21
NOL10-LAP3	chr2	10784445	chr4	17583910	987	DRB3-0105	GIYYIPDFPSVVLVG	7	22
NOL10-LAP3	chr2	10784445	chr4	17583910	987	DRB3-0105	MGIYYIPDFPSVVLV	6	21
NOL10-LAP3	chr2	10784445	chr4	17583910	987	DRB3-0108	GIYYIPDFPSVVLVG	7	22
NOL10-LAP3	chr2	10784445	chr4	17583910	987	DRB3-0108	MGIYYIPDFPSVVLV	6	21
NOL10-LAP3	chr2	10784445	chr4	17583910	987	DRB3-0109	GIYYIPDFPSVVLVG	7	22
NOL10-LAP3	chr2	10784445	chr4	17583910	987	DRB3-0109	MGIYYIPDFPSVVLV	6	21
NOL10-LAP3	chr2	10784445	chr4	17583910	987	DRB3-0111	GIYYIPDFPSVVLVG	7	22
NOL10-LAP3	chr2	10784445	chr4	17583910	987	DRB3-0111	MGIYYIPDFPSVVLV	6	21
NOL10-LAP3	chr2	10784445	chr4	17583910	987	DRB3-0112	GIYYIPDFPSVVLVG	7	22
NOL10-LAP3	chr2	10784445	chr4	17583910	987	DRB3-0112	MGIYYIPDFPSVVLV	6	21
NOL10-LAP3	chr2	10784445	chr4	17583910	987	DRB3-0113	GIYYIPDFPSVVLVG	7	22
NOL10-LAP3	chr2	10784445	chr4	17583910	987	DRB3-0113	MGIYYIPDFPSVVLV	6	21
NOL10-LAP3	chr2	10784445	chr4	17583910	987	DRB3-0114	GIYYIPDFPSVVLVG	7	22
NOL10-LAP3	chr2	10784445	chr4	17583910	987	DRB3-0303	GIYYIPDFPSVVLVG	7	22
NOL10-LAP3	chr2	10784445	chr4	17583910	987	DRB3-0303	MGIYYIPDFPSVVLV	6	21

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Fusion breakpoint peptide structures of NOL10-LAP3

3D structures of the fusion breakpoint peptide of 14AA sequence that have potential fusion neoantigens
* The minimum length of the amino acid sequence in RoseTTAFold is 14AA. Here, we predicted the 14AA fusion protein breakpoint sequence not the fusion neoantigen peptide, which is shorter than 14 AA.

File name	BPseq	Hgene	Tgene	Hchr	Hbp	Tchr	Tbp	AAlen
5910	MGIYYIPDFPSVVL	NOL10	LAP3	chr2	10784445	chr4	17583910	987

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Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D of NOL10-LAP3

Virtual screening between 25 HLAs (from PDB) and FusionNeoAntigens
* We used Glide to predict the interaction between HLAs and neoantigens.

HLA allele	PDB ID	File name	BPseq	Docking score	Glide score
HLA-B14:02	3BVN	5910	MGIYYIPDFPSVVL	-7.9962	-8.1096
HLA-B14:02	3BVN	5910	MGIYYIPDFPSVVL	-5.70842	-6.74372
HLA-B52:01	3W39	5910	MGIYYIPDFPSVVL	-6.83737	-6.95077
HLA-B52:01	3W39	5910	MGIYYIPDFPSVVL	-4.4836	-5.5189
HLA-A11:01	4UQ2	5910	MGIYYIPDFPSVVL	-10.0067	-10.1201
HLA-A11:01	4UQ2	5910	MGIYYIPDFPSVVL	-9.03915	-10.0745
HLA-A24:02	5HGA	5910	MGIYYIPDFPSVVL	-6.56204	-6.67544
HLA-A24:02	5HGA	5910	MGIYYIPDFPSVVL	-5.42271	-6.45801
HLA-B44:05	3DX8	5910	MGIYYIPDFPSVVL	-7.85648	-8.89178
HLA-B44:05	3DX8	5910	MGIYYIPDFPSVVL	-5.3978	-5.5112
HLA-A02:01	6TDR	5910	MGIYYIPDFPSVVL	-3.37154	-4.40684

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Vaccine Design for the FusionNeoAntigens of NOL10-LAP3

mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-Is.

Fusion gene	Hchr	Hbp	Tchr	Tbp	Start in +/-13AA	End in +/-13AA	FusionNeoAntigen peptide sequence	FusionNeoAntigen RNA sequence
NOL10-LAP3	chr2	10784445	chr4	17583910	10	18	YIPDFPSV	TACATTCCAGACTTCCCCAGCGTG
NOL10-LAP3	chr2	10784445	chr4	17583910	10	19	YIPDFPSVV	TACATTCCAGACTTCCCCAGCGTGGTG
NOL10-LAP3	chr2	10784445	chr4	17583910	10	20	YIPDFPSVVL	TACATTCCAGACTTCCCCAGCGTGGTGCTA
NOL10-LAP3	chr2	10784445	chr4	17583910	10	21	YIPDFPSVVLV	TACATTCCAGACTTCCCCAGCGTGGTGCTAGTT
NOL10-LAP3	chr2	10784445	chr4	17583910	11	19	IPDFPSVV	ATTCCAGACTTCCCCAGCGTGGTG
NOL10-LAP3	chr2	10784445	chr4	17583910	11	20	IPDFPSVVL	ATTCCAGACTTCCCCAGCGTGGTGCTA
NOL10-LAP3	chr2	10784445	chr4	17583910	11	21	IPDFPSVVLV	ATTCCAGACTTCCCCAGCGTGGTGCTAGTT
NOL10-LAP3	chr2	10784445	chr4	17583910	12	20	PDFPSVVL	CCAGACTTCCCCAGCGTGGTGCTA
NOL10-LAP3	chr2	10784445	chr4	17583910	7	18	GIYYIPDFPSV	GGCATCTATTACATTCCAGACTTCCCCAGCGTG
NOL10-LAP3	chr2	10784445	chr4	17583910	9	18	YYIPDFPSV	TATTACATTCCAGACTTCCCCAGCGTG
NOL10-LAP3	chr2	10784445	chr4	17583910	9	19	YYIPDFPSVV	TATTACATTCCAGACTTCCCCAGCGTGGTG
NOL10-LAP3	chr2	10784445	chr4	17583910	9	20	YYIPDFPSVVL	TATTACATTCCAGACTTCCCCAGCGTGGTGCTA

mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-IIs.

Fusion gene	Hchr	Hbp	Tchr	Tbp	Start in +/-13AA	End in +/-13AA	FusionNeoAntigen peptide	FusionNEoAntigen RNA sequence
NOL10-LAP3	chr2	10784445	chr4	17583910	3	18	TPKMGIYYIPDFPSV	ACCCCCAAGATGGGCATCTATTACATTCCAGACTTCCCCAGCGTG
NOL10-LAP3	chr2	10784445	chr4	17583910	4	19	PKMGIYYIPDFPSVV	CCCAAGATGGGCATCTATTACATTCCAGACTTCCCCAGCGTGGTG
NOL10-LAP3	chr2	10784445	chr4	17583910	5	20	KMGIYYIPDFPSVVL	AAGATGGGCATCTATTACATTCCAGACTTCCCCAGCGTGGTGCTA
NOL10-LAP3	chr2	10784445	chr4	17583910	6	21	MGIYYIPDFPSVVLV	ATGGGCATCTATTACATTCCAGACTTCCCCAGCGTGGTGCTAGTT
NOL10-LAP3	chr2	10784445	chr4	17583910	7	22	GIYYIPDFPSVVLVG	GGCATCTATTACATTCCAGACTTCCCCAGCGTGGTGCTAGTTGGC

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Information of the samples that have these potential fusion neoantigens of NOL10-LAP3

These samples were reported as having these fusion breakpoints. For individual breakpoints, we checked the open reading frames considering multiple gene isoforms and chose the in-frame fusion genes only. Then, we made fusion protein sequences and predicted the fusion neoantigens. These fusion-positive samples may have these potential fusion neoantigens.

Cancer type	Fusion gene	Hchr	Hbp	Henst	Tchr	Tbp	Tenst	Sample
STAD	NOL10-LAP3	chr2	10784445	ENST00000345985	chr4	17583910	ENST00000226299	TCGA-D7-A4YX

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Potential target of CAR-T therapy development for NOL10-LAP3

Predicted 3D structure. We used RoseTTAFold.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, to provide the retention of the transmembrane domain, we only show the protein feature retention information of those transmembrane features

* Minus value of BPloci means that the break point is located before the CDS.

- In-frame and retained 'Transmembrane'.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Subcellular localization prediction of the transmembrane domain retained fusion proteins
* We used DeepLoc 1.0. The order of the X-axis of the barplot is as follows: Entry_ID, Localization, Type, Nucleus, Cytoplasm, Extracellular, Mitochondrion, Cell_membrane, Endoplasmic_reticulum, Plastid, Golgi.apparatus, Lysosome.Vacuole, Peroxisome. Y-axis is the output score of DeepLoc. Clicking the image will open a new tab with a large image.

Hgene

Hchr

Hbp

Henst

Tgene

Tchr

Tbp

Tenst

DeepLoc result

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Related Drugs to NOL10-LAP3

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to NOL10-LAP3

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source

	Fusion Gene and Fusion Protein Summary
	Fusion Amino Acid Sequences (multiple BPs and multiple gene isoforms)
	Fusion Protein Breakpoint Sequences - (for the Screening of the FusionNeoAntigens)
	Potential FusionNeoAntigens in HLA I - (netMHCpan v4.1 + deepHLApan v1.1)
	Potential FusionNeoAntigens in HLA II - (netMHCIIpan v4.1)
	Fusion Breakpoint 14 AA Peptide Structure - (RoseTTAFold)
	Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D - (Glide)
	Vaccine Design for the FusionNeoAntigens (RNA/protein sequences)
	Potential target of CAR-T therapy development
	Information on the samples that have these potential fusion neoantigens
	Fusion Protein Targeting Drugs - (Manual Curation)
	Fusion Protein Related diseases - (Manual Curation)