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Center for Computational Systems Medicine
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Fusion Gene and Fusion Protein Summary

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Fusion Amino Acid Sequences (multiple BPs and multiple gene isoforms)

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Fusion Protein Breakpoint Sequences - (for the Screening of the FusionNeoAntigens)

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Potential FusionNeoAntigens in HLA I - (netMHCpan v4.1 + deepHLApan v1.1)

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Potential FusionNeoAntigens in HLA II - (netMHCIIpan v4.1)

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Fusion Breakpoint 14 AA Peptide Structure - (RoseTTAFold)

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Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D - (Glide)

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Vaccine Design for the FusionNeoAntigens (RNA/protein sequences)

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Potential target of CAR-T therapy development

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Information on the samples that have these potential fusion neoantigens

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Fusion Protein Targeting Drugs - (Manual Curation)

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Fusion Protein Related diseases - (Manual Curation)

Fusion Protein:NVL-NFYC

Fusion Gene and Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: NVL-NFYC
FusionPDB ID: 61189
FusionGDB2.0 ID: 61189
HgeneTgene
Gene symbol

NVL

NFYC

Gene ID

4931

4802

Gene namenuclear VCP likenuclear transcription factor Y subunit gamma
SynonymsNVL2CBF-C|CBFC|H1TF2A|HAP5|HSM|NF-YC
Cytomap

1q42.11

1p34.2

Type of geneprotein-codingprotein-coding
Descriptionnuclear valosin-containing protein-likeNVLpnuclear transcription factor Y subunit gammaCAAT box DNA-binding protein subunit CCCAAT binding factor subunit CCCAAT transcription binding factor subunit gammahistone H1 transcription factor large subunit 2Anuclear transcription factor Y subunit Cn
Modification date2020031320200313
UniProtAcc.

Q13952

Main function of 5'-partner protein: FUNCTION: Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors.
Ensembl transtripts involved in fusion geneENST idsENST00000281701, ENST00000340871, 
ENST00000361463, ENST00000391875, 
ENST00000469075, ENST00000482491, 
ENST00000468673, 		ENST00000483091, 
ENST00000308733, ENST00000372651, 
ENST00000372652, ENST00000372653, 
ENST00000372654, ENST00000425457, 
ENST00000427410, ENST00000440226, 
ENST00000447388, ENST00000456393, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score11 X 11 X 8=96816 X 10 X 7=1120
# samples 1218
** MAII scorelog2(12/968*10)=-3.01197264166608
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(18/1120*10)=-2.63742992061529
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Fusion gene context

PubMed: NVL [Title/Abstract] AND NFYC [Title/Abstract] AND fusion [Title/Abstract]

Fusion neoantigen context

PubMed: NVL [Title/Abstract] AND NFYC [Title/Abstract] AND neoantigen [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)NVL(224473727)-NFYC(41223792), # samples:1
Anticipated loss of major functional domain due to fusion event.NVL-NFYC seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
NVL-NFYC seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
NVL-NFYC seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
NVL-NFYC seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
NVL-NFYC seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
NVL-NFYC seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF.
NVL-NFYC seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNVL

GO:0006364

rRNA processing

29107693

HgeneNVL

GO:0032092

positive regulation of protein binding

29107693

HgeneNVL

GO:0042273

ribosomal large subunit biogenesis

26166824

HgeneNVL

GO:1904749

regulation of protein localization to nucleolus

29107693

TgeneNFYC

GO:0006355

regulation of transcription, DNA-templated

15243141



check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:224473727/chr1:41223792)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonRetention analysis results of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features, are available here.

check buttonFusion gene breakpoints across NVL (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across NFYC (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Amino Acid Sequences


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000391875NVLchr1224473727-ENST00000427410NFYCchr141223792+27871868562488810
ENST00000391875NVLchr1224473727-ENST00000447388NFYCchr141223792+32641868562488810
ENST00000391875NVLchr1224473727-ENST00000425457NFYCchr141223792+28571868562545829
ENST00000391875NVLchr1224473727-ENST00000456393NFYCchr141223792+32591868562485809
ENST00000391875NVLchr1224473727-ENST00000372654NFYCchr141223792+27631868562488810
ENST00000391875NVLchr1224473727-ENST00000372653NFYCchr141223792+26651868562386776
ENST00000391875NVLchr1224473727-ENST00000372652NFYCchr141223792+35761868562800914
ENST00000391875NVLchr1224473727-ENST00000372651NFYCchr141223792+26011868562488810
ENST00000391875NVLchr1224473727-ENST00000440226NFYCchr141223792+27541868562488810
ENST00000391875NVLchr1224473727-ENST00000308733NFYCchr141223792+36331868562857933
ENST00000281701NVLchr1224473727-ENST00000427410NFYCchr141223792+307821592242779851
ENST00000281701NVLchr1224473727-ENST00000447388NFYCchr141223792+355521592242779851
ENST00000281701NVLchr1224473727-ENST00000425457NFYCchr141223792+314821592242836870
ENST00000281701NVLchr1224473727-ENST00000456393NFYCchr141223792+355021592242776850
ENST00000281701NVLchr1224473727-ENST00000372654NFYCchr141223792+305421592242779851
ENST00000281701NVLchr1224473727-ENST00000372653NFYCchr141223792+295621592242677817
ENST00000281701NVLchr1224473727-ENST00000372652NFYCchr141223792+386721592243091955
ENST00000281701NVLchr1224473727-ENST00000372651NFYCchr141223792+289221592242779851
ENST00000281701NVLchr1224473727-ENST00000440226NFYCchr141223792+304521592242779851
ENST00000281701NVLchr1224473727-ENST00000308733NFYCchr141223792+392421592243148974
ENST00000469075NVLchr1224473727-ENST00000427410NFYCchr141223792+25561637112257748
ENST00000469075NVLchr1224473727-ENST00000447388NFYCchr141223792+30331637112257748
ENST00000469075NVLchr1224473727-ENST00000425457NFYCchr141223792+26261637112314767
ENST00000469075NVLchr1224473727-ENST00000456393NFYCchr141223792+30281637112254747
ENST00000469075NVLchr1224473727-ENST00000372654NFYCchr141223792+25321637112257748
ENST00000469075NVLchr1224473727-ENST00000372653NFYCchr141223792+24341637112155714
ENST00000469075NVLchr1224473727-ENST00000372652NFYCchr141223792+33451637112569852
ENST00000469075NVLchr1224473727-ENST00000372651NFYCchr141223792+23701637112257748
ENST00000469075NVLchr1224473727-ENST00000440226NFYCchr141223792+25231637112257748
ENST00000469075NVLchr1224473727-ENST00000308733NFYCchr141223792+34021637112626871
ENST00000361463NVLchr1224473727-ENST00000427410NFYCchr141223792+27581839272459810
ENST00000361463NVLchr1224473727-ENST00000447388NFYCchr141223792+32351839272459810
ENST00000361463NVLchr1224473727-ENST00000425457NFYCchr141223792+28281839272516829
ENST00000361463NVLchr1224473727-ENST00000456393NFYCchr141223792+32301839272456809
ENST00000361463NVLchr1224473727-ENST00000372654NFYCchr141223792+27341839272459810
ENST00000361463NVLchr1224473727-ENST00000372653NFYCchr141223792+26361839272357776
ENST00000361463NVLchr1224473727-ENST00000372652NFYCchr141223792+35471839272771914
ENST00000361463NVLchr1224473727-ENST00000372651NFYCchr141223792+25721839272459810
ENST00000361463NVLchr1224473727-ENST00000440226NFYCchr141223792+27251839272459810
ENST00000361463NVLchr1224473727-ENST00000308733NFYCchr141223792+36041839272828933

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000391875ENST00000427410NVLchr1224473727-NFYCchr141223792+0.0129889210.9870111
ENST00000391875ENST00000447388NVLchr1224473727-NFYCchr141223792+0.0086857720.99131423
ENST00000391875ENST00000425457NVLchr1224473727-NFYCchr141223792+0.011318230.9886818
ENST00000391875ENST00000456393NVLchr1224473727-NFYCchr141223792+0.0085407730.99145925
ENST00000391875ENST00000372654NVLchr1224473727-NFYCchr141223792+0.0134194970.9865805
ENST00000391875ENST00000372653NVLchr1224473727-NFYCchr141223792+0.0113952550.9886048
ENST00000391875ENST00000372652NVLchr1224473727-NFYCchr141223792+0.0072760230.992724
ENST00000391875ENST00000372651NVLchr1224473727-NFYCchr141223792+0.015808580.9841914
ENST00000391875ENST00000440226NVLchr1224473727-NFYCchr141223792+0.0142418610.9857582
ENST00000391875ENST00000308733NVLchr1224473727-NFYCchr141223792+0.0064277460.99357224
ENST00000281701ENST00000427410NVLchr1224473727-NFYCchr141223792+0.0023444330.9976555
ENST00000281701ENST00000447388NVLchr1224473727-NFYCchr141223792+0.001718390.9982816
ENST00000281701ENST00000425457NVLchr1224473727-NFYCchr141223792+0.0017966120.9982034
ENST00000281701ENST00000456393NVLchr1224473727-NFYCchr141223792+0.0016376310.99836236
ENST00000281701ENST00000372654NVLchr1224473727-NFYCchr141223792+0.0024119720.99758804
ENST00000281701ENST00000372653NVLchr1224473727-NFYCchr141223792+0.0020925140.9979075
ENST00000281701ENST00000372652NVLchr1224473727-NFYCchr141223792+0.0011313320.99886864
ENST00000281701ENST00000372651NVLchr1224473727-NFYCchr141223792+0.0027099140.99729013
ENST00000281701ENST00000440226NVLchr1224473727-NFYCchr141223792+0.002596890.9974031
ENST00000281701ENST00000308733NVLchr1224473727-NFYCchr141223792+0.0009913880.9990086
ENST00000469075ENST00000427410NVLchr1224473727-NFYCchr141223792+0.0041748750.9958252
ENST00000469075ENST00000447388NVLchr1224473727-NFYCchr141223792+0.0026780650.9973219
ENST00000469075ENST00000425457NVLchr1224473727-NFYCchr141223792+0.0035941940.99640584
ENST00000469075ENST00000456393NVLchr1224473727-NFYCchr141223792+0.002652340.9973476
ENST00000469075ENST00000372654NVLchr1224473727-NFYCchr141223792+0.0043483610.99565166
ENST00000469075ENST00000372653NVLchr1224473727-NFYCchr141223792+0.0039150470.9960849
ENST00000469075ENST00000372652NVLchr1224473727-NFYCchr141223792+0.0030388680.99696106
ENST00000469075ENST00000372651NVLchr1224473727-NFYCchr141223792+0.0055925710.9944074
ENST00000469075ENST00000440226NVLchr1224473727-NFYCchr141223792+0.0047659050.9952341
ENST00000469075ENST00000308733NVLchr1224473727-NFYCchr141223792+0.0025995660.9974004
ENST00000361463ENST00000427410NVLchr1224473727-NFYCchr141223792+0.0128287730.98717123
ENST00000361463ENST00000447388NVLchr1224473727-NFYCchr141223792+0.0085323270.9914677
ENST00000361463ENST00000425457NVLchr1224473727-NFYCchr141223792+0.0112253490.98877466
ENST00000361463ENST00000456393NVLchr1224473727-NFYCchr141223792+0.0083838930.9916161
ENST00000361463ENST00000372654NVLchr1224473727-NFYCchr141223792+0.0132939320.9867061
ENST00000361463ENST00000372653NVLchr1224473727-NFYCchr141223792+0.0112157570.9887842
ENST00000361463ENST00000372652NVLchr1224473727-NFYCchr141223792+0.0073170750.9926829
ENST00000361463ENST00000372651NVLchr1224473727-NFYCchr141223792+0.016026080.9839739
ENST00000361463ENST00000440226NVLchr1224473727-NFYCchr141223792+0.0142281630.98577183
ENST00000361463ENST00000308733NVLchr1224473727-NFYCchr141223792+0.0065202660.9934797

check button Predicted full-length fusion amino acid sequences. For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among all the predicted ones.

Get the fusion protein sequences from here.

Fusion protein sequence information is available in the fasta format.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

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Fusion Protein Breakpoint Sequences for NVL-NFYC

check button +/-13 AA sequence from the breakpoints of the fusion protein sequences.
HgeneHchrHbpTgeneTchrTbpLength(fusion protein)BP in fusion proteinPeptide
NVLchr1224473727NFYCchr1412237921637542AGPPGCGKTLLAKEEVRQSVTPAEPV
NVLchr1224473727NFYCchr1412237921839604AGPPGCGKTLLAKEEVRQSVTPAEPV
NVLchr1224473727NFYCchr1412237921868604AGPPGCGKTLLAKEEVRQSVTPAEPV
NVLchr1224473727NFYCchr1412237922159645AGPPGCGKTLLAKEEVRQSVTPAEPV

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Potential FusionNeoAntigen Information of NVL-NFYC in HLA I

check button Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.
NVL-NFYC_224473727_41223792.msa

check button Potential FusionNeoAntigen Information
* We used NetMHCpan v4.1 (%rank<0.5) and deepHLApan v1.1 (immunogenic score>0.5)
Fusion geneHchrHbpTgeneTchrTbpHLA IFusionNeoAntigen peptideBinding scoreImmunogenic scoreNeoantigen start (at BP 13)Neoantigen end (at BP 13)
NVL-NFYCchr1224473727chr1412237922159HLA-B41:01KEEVRQSV0.99810.8651220
NVL-NFYCchr1224473727chr1412237922159HLA-B39:13AKEEVRQSV0.95880.87681120
NVL-NFYCchr1224473727chr1412237922159HLA-B40:06KEEVRQSV10.80951220
NVL-NFYCchr1224473727chr1412237922159HLA-B41:03KEEVRQSV0.99780.63791220
NVL-NFYCchr1224473727chr1412237922159HLA-B39:02AKEEVRQSV0.98620.86991120

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Potential FusionNeoAntigen Information of NVL-NFYC in HLA II

check button Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.
NVL-NFYC_224473727_41223792.msa

check button Potential FusionNeoAntigen Information
* We used NetMHCIIpan v4.1 (%rank<0.5).
Fusion geneHchrHbpTgeneTchrTbpHLA IIFusionNeoAntigen peptideNeoantigen start (at BP 13)Neoantigen end (at BP 13)
NVL-NFYCchr1224473727chr1412237922159DRB1-0403AKEEVRQSVTPAEPV1126
NVL-NFYCchr1224473727chr1412237922159DRB1-0411AKEEVRQSVTPAEPV1126
NVL-NFYCchr1224473727chr1412237922159DRB1-0411LAKEEVRQSVTPAEP1025
NVL-NFYCchr1224473727chr1412237922159DRB1-0417AKEEVRQSVTPAEPV1126
NVL-NFYCchr1224473727chr1412237922159DRB1-0439AKEEVRQSVTPAEPV1126
NVL-NFYCchr1224473727chr1412237922159DRB1-0441AKEEVRQSVTPAEPV1126
NVL-NFYCchr1224473727chr1412237922159DRB1-0446AKEEVRQSVTPAEPV1126
NVL-NFYCchr1224473727chr1412237922159DRB1-0449AKEEVRQSVTPAEPV1126
NVL-NFYCchr1224473727chr1412237922159DRB1-0450AKEEVRQSVTPAEPV1126
NVL-NFYCchr1224473727chr1412237922159DRB1-0451AKEEVRQSVTPAEPV1126
NVL-NFYCchr1224473727chr1412237922159DRB1-0452AKEEVRQSVTPAEPV1126
NVL-NFYCchr1224473727chr1412237922159DRB1-0460AKEEVRQSVTPAEPV1126
NVL-NFYCchr1224473727chr1412237922159DRB1-0467AKEEVRQSVTPAEPV1126
NVL-NFYCchr1224473727chr1412237922159DRB1-0467LAKEEVRQSVTPAEP1025
NVL-NFYCchr1224473727chr1412237922159DRB1-0471AKEEVRQSVTPAEPV1126
NVL-NFYCchr1224473727chr1412237922159DRB1-0485AKEEVRQSVTPAEPV1126
NVL-NFYCchr1224473727chr1412237922159DRB1-0491AKEEVRQSVTPAEPV1126
NVL-NFYCchr1224473727chr1412237922159DRB1-0491LAKEEVRQSVTPAEP1025
NVL-NFYCchr1224473727chr1412237922159DRB1-0804GKTLLAKEEVRQSVT621
NVL-NFYCchr1224473727chr1412237922159DRB1-0804CGKTLLAKEEVRQSV520
NVL-NFYCchr1224473727chr1412237922159DRB1-0828GKTLLAKEEVRQSVT621
NVL-NFYCchr1224473727chr1412237922159DRB1-1167GKTLLAKEEVRQSVT621
NVL-NFYCchr1224473727chr1412237922159DRB1-1410AKEEVRQSVTPAEPV1126
NVL-NFYCchr1224473727chr1412237922159DRB1-1415GKTLLAKEEVRQSVT621
NVL-NFYCchr1224473727chr1412237922159DRB1-1415CGKTLLAKEEVRQSV520

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Fusion breakpoint peptide structures of NVL-NFYC

check button3D structures of the fusion breakpoint peptide of 14AA sequence that have potential fusion neoantigens
* The minimum length of the amino acid sequence in RoseTTAFold is 14AA. Here, we predicted the 14AA fusion protein breakpoint sequence not the fusion neoantigen peptide, which is shorter than 14 AA.
File nameBPseqHgeneTgeneHchrHbpTchrTbpAAlen
2917GKTLLAKEEVRQSVNVLNFYCchr1224473727chr1412237922159

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Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D of NVL-NFYC

check buttonVirtual screening between 25 HLAs (from PDB) and FusionNeoAntigens
* We used Glide to predict the interaction between HLAs and neoantigens.
HLA allelePDB IDFile nameBPseqDocking scoreGlide score
HLA-B52:013W392917GKTLLAKEEVRQSV-5.13061-5.13061
HLA-B44:053DX82917GKTLLAKEEVRQSV-5.47157-5.47157

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Vaccine Design for the FusionNeoAntigens of NVL-NFYC

check button mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-Is.
Fusion geneHchrHbpTchrTbpStart in +/-13AAEnd in +/-13AAFusionNeoAntigen peptide sequenceFusionNeoAntigen RNA sequence
NVL-NFYCchr1224473727chr1412237921120AKEEVRQSVGCGAAGGAGGAGGTGCGCCAGTCTGTA
NVL-NFYCchr1224473727chr1412237921220KEEVRQSVAAGGAGGAGGTGCGCCAGTCTGTA

check button mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-IIs.
Fusion geneHchrHbpTchrTbpStart in +/-13AAEnd in +/-13AAFusionNeoAntigen peptideFusionNEoAntigen RNA sequence
NVL-NFYCchr1224473727chr1412237921025LAKEEVRQSVTPAEPCTGGCGAAGGAGGAGGTGCGCCAGTCTGTAACTCCTGCCGAGCCA
NVL-NFYCchr1224473727chr1412237921126AKEEVRQSVTPAEPVGCGAAGGAGGAGGTGCGCCAGTCTGTAACTCCTGCCGAGCCAGTC
NVL-NFYCchr1224473727chr141223792520CGKTLLAKEEVRQSVTGTGGGAAGACTCTGCTGGCGAAGGAGGAGGTGCGCCAGTCTGTA
NVL-NFYCchr1224473727chr141223792621GKTLLAKEEVRQSVTGGGAAGACTCTGCTGGCGAAGGAGGAGGTGCGCCAGTCTGTAACT

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Information of the samples that have these potential fusion neoantigens of NVL-NFYC

check button These samples were reported as having these fusion breakpoints. For individual breakpoints, we checked the open reading frames considering multiple gene isoforms and chose the in-frame fusion genes only. Then, we made fusion protein sequences and predicted the fusion neoantigens. These fusion-positive samples may have these potential fusion neoantigens.
Cancer typeFusion geneHchrHbpHenstTchrTbpTenstSample
Non-CancerNVL-NFYCchr1224473727ENST00000281701chr141223792ENST00000308733TCGA-CV-7437-11A

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Potential target of CAR-T therapy development for NVL-NFYC

check button Predicted 3D structure. We used RoseTTAFold.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, to provide the retention of the transmembrane domain, we only show the protein feature retention information of those transmembrane features


* Minus value of BPloci means that the break point is located before the CDS.
- In-frame and retained 'Transmembrane'.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

check button Subcellular localization prediction of the transmembrane domain retained fusion proteins
* We used DeepLoc 1.0. The order of the X-axis of the barplot is as follows: Entry_ID, Localization, Type, Nucleus, Cytoplasm, Extracellular, Mitochondrion, Cell_membrane, Endoplasmic_reticulum, Plastid, Golgi.apparatus, Lysosome.Vacuole, Peroxisome. Y-axis is the output score of DeepLoc. Clicking the image will open a new tab with a large image.
HgeneHchrHbpHenstTgeneTchrTbpTenstDeepLoc result

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Related Drugs to NVL-NFYC

check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to NVL-NFYC

check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource