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Center for Computational Systems Medicine
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Fusion Gene and Fusion Protein Summary

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Fusion Amino Acid Sequences (multiple BPs and multiple gene isoforms)

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Fusion Protein Breakpoint Sequences - (for the Screening of the FusionNeoAntigens)

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Potential FusionNeoAntigens in HLA I - (netMHCpan v4.1 + deepHLApan v1.1)

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Potential FusionNeoAntigens in HLA II - (netMHCIIpan v4.1)

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Fusion Breakpoint 14 AA Peptide Structure - (RoseTTAFold)

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Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D - (Glide)

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Vaccine Design for the FusionNeoAntigens (RNA/protein sequences)

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Potential target of CAR-T therapy development

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Information on the samples that have these potential fusion neoantigens

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Fusion Protein Targeting Drugs - (Manual Curation)

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Fusion Protein Related diseases - (Manual Curation)

Fusion Protein:OXR1-MET

Fusion Gene and Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: OXR1-MET
FusionPDB ID: 62040
FusionGDB2.0 ID: 62040
HgeneTgene
Gene symbol

OXR1

MET

Gene ID

55074

8731

Gene nameoxidation resistance 1RNA guanine-7 methyltransferase
SynonymsCHEGDD|Nbla00307|TLDC3CMT1|CMT1c|MET|Met|RG7MT1|cm1p|hCMT1|hMet
Cytomap

8q23.1

18p11.21

Type of geneprotein-codingprotein-coding
Descriptionoxidation resistance protein 1TBC/LysM-associated domain containing 3putative protein product of Nbla00307mRNA cap guanine-N7 methyltransferaseRNA (guanine-7-) methyltransferasehcm1pmRNA (guanine-7-)methyltransferasemRNA (guanine-N(7)-)-methyltransferasemRNA cap methyltransferase
Modification date2020031320200329
UniProtAcc.

Q9H1A3

Main function of 5'-partner protein:
Ensembl transtripts involved in fusion geneENST idsENST00000297447, ENST00000312046, 
ENST00000442977, ENST00000445937, 
ENST00000449762, ENST00000452423, 
ENST00000517566, ENST00000531443, 
ENST00000497705, ENST00000521592, 
ENST00000521963, 		ENST00000436117, 
ENST00000495962, ENST00000539704, 
ENST00000318493, ENST00000397752, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score23 X 21 X 9=434714 X 18 X 10=2520
# samples 2527
** MAII scorelog2(25/4347*10)=-4.120020095616
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(27/2520*10)=-3.22239242133645
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Fusion gene context

PubMed: OXR1 [Title/Abstract] AND MET [Title/Abstract] AND fusion [Title/Abstract]

Fusion neoantigen context

PubMed: OXR1 [Title/Abstract] AND MET [Title/Abstract] AND neoantigen [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)OXR1(107738537)-MET(116411552), # samples:2
OXR1(107726213)-MET(116411552), # samples:2
Anticipated loss of major functional domain due to fusion event.OXR1-MET seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
OXR1-MET seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
OXR1-MET seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
OXR1-MET seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneMET

GO:0006370

7-methylguanosine mRNA capping

27422871



check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:107738537/chr7:116411552)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonRetention analysis results of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features, are available here.

check buttonFusion gene breakpoints across OXR1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across MET (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Amino Acid Sequences


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000449762OXR1chr8107738537+ENST00000397752METchr7116411552+40032982321740502
ENST00000449762OXR1chr8107738537+ENST00000318493METchr7116411552+19592982321740502
ENST00000297447OXR1chr8107738537+ENST00000397752METchr7116411552+39082031371645502
ENST00000297447OXR1chr8107738537+ENST00000318493METchr7116411552+18642031371645502
ENST00000445937OXR1chr8107726213+ENST00000397752METchr7116411552+5922221721936591146
ENST00000445937OXR1chr8107726213+ENST00000318493METchr7116411552+3878221721936591146
ENST00000531443OXR1chr8107726213+ENST00000397752METchr7116411552+579920949635361146
ENST00000531443OXR1chr8107726213+ENST00000318493METchr7116411552+375520949635361146
ENST00000517566OXR1chr8107726213+ENST00000397752METchr7116411552+579920949635361146
ENST00000517566OXR1chr8107726213+ENST00000318493METchr7116411552+375520949635361146
ENST00000452423OXR1chr8107726213+ENST00000397752METchr7116411552+579920949635361146
ENST00000452423OXR1chr8107726213+ENST00000318493METchr7116411552+375520949635361146
ENST00000442977OXR1chr8107726213+ENST00000397752METchr7116411552+576320588135001139
ENST00000442977OXR1chr8107726213+ENST00000318493METchr7116411552+371920588135001139
ENST00000312046OXR1chr8107726213+ENST00000397752METchr7116411552+5773206813335101125
ENST00000312046OXR1chr8107726213+ENST00000318493METchr7116411552+3729206813335101125

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000449762ENST00000397752OXR1chr8107738537+METchr7116411552+0.0003904130.99960965
ENST00000449762ENST00000318493OXR1chr8107738537+METchr7116411552+0.0006803030.9993197
ENST00000297447ENST00000397752OXR1chr8107738537+METchr7116411552+0.0003896770.99961036
ENST00000297447ENST00000318493OXR1chr8107738537+METchr7116411552+0.0006675490.99933237
ENST00000445937ENST00000397752OXR1chr8107726213+METchr7116411552+0.0001419840.999858
ENST00000445937ENST00000318493OXR1chr8107726213+METchr7116411552+0.000276760.99972326
ENST00000531443ENST00000397752OXR1chr8107726213+METchr7116411552+0.0001179130.9998821
ENST00000531443ENST00000318493OXR1chr8107726213+METchr7116411552+0.0002189810.9997811
ENST00000517566ENST00000397752OXR1chr8107726213+METchr7116411552+0.0001179130.9998821
ENST00000517566ENST00000318493OXR1chr8107726213+METchr7116411552+0.0002189810.9997811
ENST00000452423ENST00000397752OXR1chr8107726213+METchr7116411552+0.0001179130.9998821
ENST00000452423ENST00000318493OXR1chr8107726213+METchr7116411552+0.0002189810.9997811
ENST00000442977ENST00000397752OXR1chr8107726213+METchr7116411552+0.000117760.9998822
ENST00000442977ENST00000318493OXR1chr8107726213+METchr7116411552+0.0002369180.9997631
ENST00000312046ENST00000397752OXR1chr8107726213+METchr7116411552+0.0001016710.9998983
ENST00000312046ENST00000318493OXR1chr8107726213+METchr7116411552+0.0001780650.99982196

check button Predicted full-length fusion amino acid sequences. For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among all the predicted ones.

Get the fusion protein sequences from here.

Fusion protein sequence information is available in the fasta format.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

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Fusion Protein Breakpoint Sequences for OXR1-MET

check button +/-13 AA sequence from the breakpoints of the fusion protein sequences.
HgeneHchrHbpTgeneTchrTbpLength(fusion protein)BP in fusion proteinPeptide
OXR1chr8107726213METchr71164115522058659EDSSNQAAAREWEWKQAISSTVLGKV
OXR1chr8107726213METchr71164115522068645EDSSNQAAAREWEWKQAISSTVLGKV
OXR1chr8107726213METchr71164115522094666EDSSNQAAAREWEWKQAISSTVLGKV
OXR1chr8107726213METchr71164115522217666EDSSNQAAAREWEWKQAISSTVLGKV
OXR1chr8107738537METchr711641155220322GRRHQPINHKYTLWKQAISSTVLGKV
OXR1chr8107738537METchr711641155229822GRRHQPINHKYTLWKQAISSTVLGKV

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Potential FusionNeoAntigen Information of OXR1-MET in HLA I

check button Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.
OXR1-MET_107726213_116411552.msa
OXR1-MET_107738537_116411552.msa

check button Potential FusionNeoAntigen Information
* We used NetMHCpan v4.1 (%rank<0.5) and deepHLApan v1.1 (immunogenic score>0.5)
Fusion geneHchrHbpTgeneTchrTbpHLA IFusionNeoAntigen peptideBinding scoreImmunogenic scoreNeoantigen start (at BP 13)Neoantigen end (at BP 13)
OXR1-METchr8107726213chr71164115522068HLA-B50:02REWEWKQA0.99920.8474917
OXR1-METchr8107726213chr71164115522068HLA-B58:02AAAREWEW0.99850.9882614
OXR1-METchr8107726213chr71164115522068HLA-B45:01REWEWKQA0.99780.8924917
OXR1-METchr8107726213chr71164115522068HLA-B58:01AAAREWEW0.99780.9911614
OXR1-METchr8107726213chr71164115522068HLA-B41:01REWEWKQA0.9740.8999917
OXR1-METchr8107726213chr71164115522068HLA-B50:01REWEWKQA0.89120.9803917
OXR1-METchr8107726213chr71164115522068HLA-B57:01QAAAREWEW0.9990.993514
OXR1-METchr8107726213chr71164115522068HLA-B13:02REWEWKQAI0.99890.9828918
OXR1-METchr8107726213chr71164115522068HLA-B48:01REWEWKQAI0.99880.7655918
OXR1-METchr8107726213chr71164115522068HLA-B40:01REWEWKQAI0.99810.7098918
OXR1-METchr8107726213chr71164115522068HLA-B13:01REWEWKQAI0.99690.9955918
OXR1-METchr8107726213chr71164115522068HLA-B58:02QAAAREWEW0.99660.9855514
OXR1-METchr8107726213chr71164115522068HLA-B58:01QAAAREWEW0.99490.9903514
OXR1-METchr8107726213chr71164115522068HLA-B50:02REWEWKQAI0.9930.8045918
OXR1-METchr8107726213chr71164115522068HLA-B47:01REWEWKQAI0.98890.7104918
OXR1-METchr8107726213chr71164115522068HLA-B44:05REWEWKQAI0.98710.5652918
OXR1-METchr8107726213chr71164115522068HLA-B45:01REWEWKQAI0.9780.9619918
OXR1-METchr8107726213chr71164115522068HLA-B44:03REWEWKQAI0.97660.953918
OXR1-METchr8107726213chr71164115522068HLA-B53:01QAAAREWEW0.94150.9185514
OXR1-METchr8107726213chr71164115522068HLA-B57:03QAAAREWEW0.90880.9959514
OXR1-METchr8107726213chr71164115522068HLA-B39:13REWEWKQAI0.80620.9477918
OXR1-METchr8107726213chr71164115522068HLA-A32:13QAAAREWEW0.75610.9728514
OXR1-METchr8107726213chr71164115522068HLA-B18:01REWEWKQAI0.65260.8758918
OXR1-METchr8107726213chr71164115522068HLA-B41:01REWEWKQAI0.54520.9623918
OXR1-METchr8107726213chr71164115522068HLA-B40:05REWEWKQAI0.52020.63918
OXR1-METchr8107726213chr71164115522068HLA-B50:01REWEWKQAI0.24590.9374918
OXR1-METchr8107726213chr71164115522068HLA-B50:01WEWKQAISS0.10060.73621120
OXR1-METchr8107726213chr71164115522068HLA-B52:01REWEWKQAI0.06160.9959918
OXR1-METchr8107726213chr71164115522068HLA-B27:05AREWEWKQAI0.99680.5374818
OXR1-METchr8107726213chr71164115522068HLA-B27:04AREWEWKQAI0.99670.7762818
OXR1-METchr8107726213chr71164115522068HLA-B27:07AREWEWKQAI0.99610.7767818
OXR1-METchr8107726213chr71164115522068HLA-B40:02AREWEWKQAI0.94790.6426818
OXR1-METchr8107726213chr71164115522068HLA-B40:05AREWEWKQAI0.7640.8122818
OXR1-METchr8107726213chr71164115522068HLA-B57:01SNQAAAREWEW0.99990.9885314
OXR1-METchr8107726213chr71164115522068HLA-B40:06REWEWKQA0.99990.8297917
OXR1-METchr8107726213chr71164115522068HLA-B40:06REWEWKQAI0.99980.8025918
OXR1-METchr8107726213chr71164115522068HLA-B48:03REWEWKQAI0.99630.7453918
OXR1-METchr8107726213chr71164115522068HLA-B44:10REWEWKQAI0.99510.8446918
OXR1-METchr8107726213chr71164115522068HLA-B40:03REWEWKQAI0.99370.605918
OXR1-METchr8107726213chr71164115522068HLA-B40:06WEWKQAISS0.99010.67041120
OXR1-METchr8107726213chr71164115522068HLA-B44:08REWEWKQAI0.97780.5974918
OXR1-METchr8107726213chr71164115522068HLA-B44:09REWEWKQAI0.96940.5981918
OXR1-METchr8107726213chr71164115522068HLA-B44:08QAAAREWEW0.66620.815514
OXR1-METchr8107726213chr71164115522068HLA-B39:08REWEWKQAI0.58750.9278918
OXR1-METchr8107726213chr71164115522068HLA-B51:07REWEWKQAI0.01910.9902918
OXR1-METchr8107726213chr71164115522068HLA-B27:14AREWEWKQAI0.99730.6469818
OXR1-METchr8107726213chr71164115522068HLA-B44:08NQAAAREWEW0.96950.5935414
OXR1-METchr8107726213chr71164115522068HLA-B27:03AREWEWKQAI0.94260.5563818
OXR1-METchr8107726213chr71164115522068HLA-B40:06AREWEWKQAI0.8760.9116818
OXR1-METchr8107726213chr71164115522068HLA-B44:10AREWEWKQAI0.450.9662818
OXR1-METchr8107726213chr71164115522068HLA-B57:04AAAREWEW0.99890.855614
OXR1-METchr8107726213chr71164115522068HLA-B50:05REWEWKQA0.89120.9803917
OXR1-METchr8107726213chr71164115522068HLA-B50:04REWEWKQA0.89120.9803917
OXR1-METchr8107726213chr71164115522068HLA-B40:40REWEWKQAI0.99990.525918
OXR1-METchr8107726213chr71164115522068HLA-B40:04REWEWKQAI0.99920.9216918
OXR1-METchr8107726213chr71164115522068HLA-B57:10QAAAREWEW0.9990.993514
OXR1-METchr8107726213chr71164115522068HLA-B40:49REWEWKQAI0.99810.7238918
OXR1-METchr8107726213chr71164115522068HLA-B40:36REWEWKQAI0.99780.6929918
OXR1-METchr8107726213chr71164115522068HLA-B57:04QAAAREWEW0.99630.8048514
OXR1-METchr8107726213chr71164115522068HLA-B40:12REWEWKQAI0.99630.7453918
OXR1-METchr8107726213chr71164115522068HLA-B40:21REWEWKQAI0.99430.766918
OXR1-METchr8107726213chr71164115522068HLA-B58:06QAAAREWEW0.99370.9855514
OXR1-METchr8107726213chr71164115522068HLA-B44:07REWEWKQAI0.97660.953918
OXR1-METchr8107726213chr71164115522068HLA-B44:26REWEWKQAI0.97660.953918
OXR1-METchr8107726213chr71164115522068HLA-B44:13REWEWKQAI0.97660.953918
OXR1-METchr8107726213chr71164115522068HLA-B57:02QAAAREWEW0.97570.9541514
OXR1-METchr8107726213chr71164115522068HLA-B15:13QAAAREWEW0.95360.985514
OXR1-METchr8107726213chr71164115522068HLA-B18:11REWEWKQAI0.87070.8812918
OXR1-METchr8107726213chr71164115522068HLA-B53:02QAAAREWEW0.84910.9064514
OXR1-METchr8107726213chr71164115522068HLA-B39:31REWEWKQAI0.75690.9437918
OXR1-METchr8107726213chr71164115522068HLA-B41:03REWEWKQAI0.73660.765918
OXR1-METchr8107726213chr71164115522068HLA-B39:02REWEWKQAI0.7290.9493918
OXR1-METchr8107726213chr71164115522068HLA-B18:05REWEWKQAI0.65260.8758918
OXR1-METchr8107726213chr71164115522068HLA-B18:06REWEWKQAI0.64870.9053918
OXR1-METchr8107726213chr71164115522068HLA-B18:08REWEWKQAI0.64790.9003918
OXR1-METchr8107726213chr71164115522068HLA-B18:03REWEWKQAI0.60440.8654918
OXR1-METchr8107726213chr71164115522068HLA-B48:02REWEWKQAI0.38080.9046918
OXR1-METchr8107726213chr71164115522068HLA-B50:04REWEWKQAI0.24590.9374918
OXR1-METchr8107726213chr71164115522068HLA-B50:05REWEWKQAI0.24590.9374918
OXR1-METchr8107726213chr71164115522068HLA-A25:01QAAAREWEW0.15830.9281514
OXR1-METchr8107726213chr71164115522068HLA-B15:53REWEWKQAI0.12950.9524918
OXR1-METchr8107726213chr71164115522068HLA-B50:05WEWKQAISS0.10060.73621120
OXR1-METchr8107726213chr71164115522068HLA-B50:04WEWKQAISS0.10060.73621120
OXR1-METchr8107726213chr71164115522068HLA-B27:06AREWEWKQAI0.99650.8576818
OXR1-METchr8107726213chr71164115522068HLA-B27:10AREWEWKQAI0.99640.8615818
OXR1-METchr8107726213chr71164115522068HLA-B27:09AREWEWKQAI0.99550.5474818
OXR1-METchr8107726213chr71164115522068HLA-B40:40AREWEWKQAI0.93990.6697818
OXR1-METchr8107726213chr71164115522068HLA-B57:10SNQAAAREWEW0.99990.9885314
OXR1-METchr8107726213chr71164115522068HLA-B57:04SNQAAAREWEW0.99940.8744314
OXR1-METchr8107738537chr7116411552203HLA-A24:25KYTLWKQAI0.99030.6374918
OXR1-METchr8107738537chr7116411552203HLA-A24:23KYTLWKQAI0.98950.6115918
OXR1-METchr8107738537chr7116411552203HLA-A24:20KYTLWKQAI0.9890.6337918
OXR1-METchr8107738537chr7116411552203HLA-A24:15KYTLWKQAI0.98880.6463918
OXR1-METchr8107738537chr7116411552203HLA-A24:31KYTLWKQAI0.98550.637918
OXR1-METchr8107738537chr7116411552203HLA-B39:06HKYTLWKQA0.96790.9751817
OXR1-METchr8107738537chr7116411552203HLA-A24:10KYTLWKQAI0.87830.5864918
OXR1-METchr8107738537chr7116411552203HLA-A24:14KYTLWKQAI0.77390.6758918
OXR1-METchr8107738537chr7116411552203HLA-A31:08KYTLWKQAI0.75140.5703918
OXR1-METchr8107738537chr7116411552203HLA-A24:02KYTLWKQAI0.9890.6337918
OXR1-METchr8107738537chr7116411552203HLA-B73:01HKYTLWKQA0.87150.9514817
OXR1-METchr8107738537chr7116411552203HLA-A24:03KYTLWKQAI0.98950.6115918
OXR1-METchr8107738537chr7116411552203HLA-B15:13QPINHKYTLW0.96160.6767414
OXR1-METchr8107738537chr7116411552203HLA-B15:24HQPINHKYTLW0.99960.906314

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Potential FusionNeoAntigen Information of OXR1-MET in HLA II

check button Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.
OXR1-MET_107726213_116411552.msa
OXR1-MET_107738537_116411552.msa

check button Potential FusionNeoAntigen Information
* We used NetMHCIIpan v4.1 (%rank<0.5).
Fusion geneHchrHbpTgeneTchrTbpHLA IIFusionNeoAntigen peptideNeoantigen start (at BP 13)Neoantigen end (at BP 13)
OXR1-METchr8107726213chr71164115522068DRB1-0711EWEWKQAISSTVLGK1025
OXR1-METchr8107726213chr71164115522068DRB1-0712EWEWKQAISSTVLGK1025
OXR1-METchr8107726213chr71164115522068DRB1-0901EWEWKQAISSTVLGK1025
OXR1-METchr8107726213chr71164115522068DRB1-0901REWEWKQAISSTVLG924
OXR1-METchr8107726213chr71164115522068DRB1-0904EWEWKQAISSTVLGK1025
OXR1-METchr8107726213chr71164115522068DRB1-0905EWEWKQAISSTVLGK1025
OXR1-METchr8107726213chr71164115522068DRB1-0907EWEWKQAISSTVLGK1025
OXR1-METchr8107726213chr71164115522068DRB1-0907REWEWKQAISSTVLG924
OXR1-METchr8107726213chr71164115522068DRB1-0909EWEWKQAISSTVLGK1025
OXR1-METchr8107726213chr71164115522068DRB1-0909REWEWKQAISSTVLG924
OXR1-METchr8107738537chr7116411552203DRB1-0907YTLWKQAISSTVLGK1025

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Fusion breakpoint peptide structures of OXR1-MET

check button3D structures of the fusion breakpoint peptide of 14AA sequence that have potential fusion neoantigens
* The minimum length of the amino acid sequence in RoseTTAFold is 14AA. Here, we predicted the 14AA fusion protein breakpoint sequence not the fusion neoantigen peptide, which is shorter than 14 AA.
File nameBPseqHgeneTgeneHchrHbpTchrTbpAAlen
14AAAREWEWKQAISSOXR1METchr8107726213chr71164115522068
File nameBPseqHgeneTgeneHchrHbpTchrTbpAAlen
3853INHKYTLWKQAISSOXR1METchr8107738537chr7116411552203

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Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D of OXR1-MET

check buttonVirtual screening between 25 HLAs (from PDB) and FusionNeoAntigens
* We used Glide to predict the interaction between HLAs and neoantigens.
HLA allelePDB IDFile nameBPseqDocking scoreGlide score
HLA-B14:023BVN14AAAREWEWKQAISS-6.33173-6.44513
HLA-B14:023BVN14AAAREWEWKQAISS-1.81046-2.84576
HLA-B52:013W3914AAAREWEWKQAISS-5.92784-6.04124
HLA-B52:013W3914AAAREWEWKQAISS-4.3074-5.3427
HLA-A24:025HGA14AAAREWEWKQAISS-6.68795-7.72325
HLA-A24:025HGA14AAAREWEWKQAISS-5.73606-5.84946
HLA-B44:053DX814AAAREWEWKQAISS-6.99493-8.03023
HLA-B44:053DX814AAAREWEWKQAISS-6.82556-6.93896
HLA-A02:016TDR14AAAREWEWKQAISS-4.47214-5.50744
HLA-B14:023BVN3853INHKYTLWKQAISS-7.15543-7.26883
HLA-B14:023BVN3853INHKYTLWKQAISS-4.77435-5.80965
HLA-B52:013W393853INHKYTLWKQAISS-6.80875-6.92215
HLA-B52:013W393853INHKYTLWKQAISS-4.20386-5.23916
HLA-A11:014UQ23853INHKYTLWKQAISS-7.5194-8.5547
HLA-A11:014UQ23853INHKYTLWKQAISS-6.9601-7.0735
HLA-A24:025HGA3853INHKYTLWKQAISS-7.52403-7.63743
HLA-A24:025HGA3853INHKYTLWKQAISS-5.82433-6.85963
HLA-B27:056PYJ3853INHKYTLWKQAISS-3.28285-4.31815
HLA-B44:053DX83853INHKYTLWKQAISS-5.91172-6.94702
HLA-B44:053DX83853INHKYTLWKQAISS-4.24346-4.35686

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Vaccine Design for the FusionNeoAntigens of OXR1-MET

check button mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-Is.
Fusion geneHchrHbpTchrTbpStart in +/-13AAEnd in +/-13AAFusionNeoAntigen peptide sequenceFusionNeoAntigen RNA sequence
OXR1-METchr8107726213chr71164115521120WEWKQAISSTGGGAGTGGAAGCAAGCAATTTCTTCA
OXR1-METchr8107726213chr7116411552314SNQAAAREWEWAGTAATCAAGCAGCAGCCAGAGAATGGGAGTGG
OXR1-METchr8107726213chr7116411552414NQAAAREWEWAATCAAGCAGCAGCCAGAGAATGGGAGTGG
OXR1-METchr8107726213chr7116411552514QAAAREWEWCAAGCAGCAGCCAGAGAATGGGAGTGG
OXR1-METchr8107726213chr7116411552614AAAREWEWGCAGCAGCCAGAGAATGGGAGTGG
OXR1-METchr8107726213chr7116411552818AREWEWKQAIGCCAGAGAATGGGAGTGGAAGCAAGCAATT
OXR1-METchr8107726213chr7116411552917REWEWKQAAGAGAATGGGAGTGGAAGCAAGCA
OXR1-METchr8107726213chr7116411552918REWEWKQAIAGAGAATGGGAGTGGAAGCAAGCAATT
OXR1-METchr8107738537chr7116411552314HQPINHKYTLWCATCAACCAATTAATCATAAATACACTCTGTGG
OXR1-METchr8107738537chr7116411552414QPINHKYTLWCAACCAATTAATCATAAATACACTCTGTGG
OXR1-METchr8107738537chr7116411552817HKYTLWKQACATAAATACACTCTGTGGAAGCAAGCA
OXR1-METchr8107738537chr7116411552918KYTLWKQAIAAATACACTCTGTGGAAGCAAGCAATT

check button mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-IIs.
Fusion geneHchrHbpTchrTbpStart in +/-13AAEnd in +/-13AAFusionNeoAntigen peptideFusionNEoAntigen RNA sequence
OXR1-METchr8107726213chr71164115521025EWEWKQAISSTVLGKGAATGGGAGTGGAAGCAAGCAATTTCTTCAACCGTCCTTGGAAAA
OXR1-METchr8107726213chr7116411552924REWEWKQAISSTVLGAGAGAATGGGAGTGGAAGCAAGCAATTTCTTCAACCGTCCTTGGA
OXR1-METchr8107738537chr71164115521025YTLWKQAISSTVLGKTACACTCTGTGGAAGCAAGCAATTTCTTCAACCGTCCTTGGAAAA

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Information of the samples that have these potential fusion neoantigens of OXR1-MET

check button These samples were reported as having these fusion breakpoints. For individual breakpoints, we checked the open reading frames considering multiple gene isoforms and chose the in-frame fusion genes only. Then, we made fusion protein sequences and predicted the fusion neoantigens. These fusion-positive samples may have these potential fusion neoantigens.
Cancer typeFusion geneHchrHbpHenstTchrTbpTenstSample
LIHCOXR1-METchr8107738537ENST00000297447chr7116411552ENST00000318493TCGA-RC-A6M6-01A
LIHCOXR1-METchr8107726213ENST00000312046chr7116411552ENST00000318493TCGA-RC-A6M6-01A

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Potential target of CAR-T therapy development for OXR1-MET

check button Predicted 3D structure. We used RoseTTAFold.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, to provide the retention of the transmembrane domain, we only show the protein feature retention information of those transmembrane features


* Minus value of BPloci means that the break point is located before the CDS.
- In-frame and retained 'Transmembrane'.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneMETchr8:107726213chr7:116411552ENST000003184931121933_95501409.0TransmembraneHelical
TgeneMETchr8:107726213chr7:116411552ENST000003977521121933_95501391.0TransmembraneHelical
TgeneMETchr8:107726213chr7:116411552ENST0000043611709933_9550765.0TransmembraneHelical
TgeneMETchr8:107738537chr7:116411552ENST000003184931121933_95501409.0TransmembraneHelical
TgeneMETchr8:107738537chr7:116411552ENST000003977521121933_95501391.0TransmembraneHelical
TgeneMETchr8:107738537chr7:116411552ENST0000043611709933_9550765.0TransmembraneHelical

check button Subcellular localization prediction of the transmembrane domain retained fusion proteins
* We used DeepLoc 1.0. The order of the X-axis of the barplot is as follows: Entry_ID, Localization, Type, Nucleus, Cytoplasm, Extracellular, Mitochondrion, Cell_membrane, Endoplasmic_reticulum, Plastid, Golgi.apparatus, Lysosome.Vacuole, Peroxisome. Y-axis is the output score of DeepLoc. Clicking the image will open a new tab with a large image.
HgeneHchrHbpHenstTgeneTchrTbpTenstDeepLoc result

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Related Drugs to OXR1-MET

check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to OXR1-MET

check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource