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Center for Computational Systems Medicine
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Fusion Gene and Fusion Protein Summary

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Fusion Amino Acid Sequences (multiple BPs and multiple gene isoforms)

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Fusion Protein Breakpoint Sequences - (for the Screening of the FusionNeoAntigens)

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Potential FusionNeoAntigens in HLA I - (netMHCpan v4.1 + deepHLApan v1.1)

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Potential FusionNeoAntigens in HLA II - (netMHCIIpan v4.1)

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Fusion Breakpoint 14 AA Peptide Structure - (RoseTTAFold)

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Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D - (Glide)

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Vaccine Design for the FusionNeoAntigens (RNA/protein sequences)

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Potential target of CAR-T therapy development

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Information on the samples that have these potential fusion neoantigens

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Fusion Protein Targeting Drugs - (Manual Curation)

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Fusion Protein Related diseases - (Manual Curation)

Fusion Protein:PACRG-QKI

Fusion Gene and Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: PACRG-QKI
FusionPDB ID: 62241
FusionGDB2.0 ID: 62241
HgeneTgene
Gene symbol

PACRG

QKI

Gene ID

135138

9444

Gene nameparkin coregulatedQKI, KH domain containing RNA binding
SynonymsGLUP|HAK005771|PACRG2.1|PARK2CRGHqk|QK|QK1|QK3|hqkI
Cytomap

6q26

6q26

Type of geneprotein-codingprotein-coding
Descriptionparkin coregulated gene proteinPARK2 co-regulatedPARK2 coregulatedmolecular chaperone/chaperonin-binding proteinparkin co-regulated gene proteinprotein quakingQKI/LOC100132735 fusionRNA binding protein HQKhomolog of mouse quaking QKI (KH domain RNA binding protein)quaking homolog, KH domain RNA binding
Modification date2020031320200327
UniProtAcc

PACRGL

Main function of 5'-partner protein: 248

Q96PU8

Main function of 5'-partner protein: FUNCTION: RNA-binding protein that plays a central role in myelinization (PubMed:16641098). Binds to the 5'-NACUAAY-N(1,20)-UAAY-3' RNA core sequence. Regulates target mRNA stability (PubMed:23630077). In addition, acts by regulating pre-mRNA splicing, mRNA export and protein translation. Required to protect and promote stability of mRNAs such as MBP and CDKN1B. Regulator of oligodendrocyte differentiation and maturation in the brain that may play a role in myelin and oligodendrocyte dysfunction in schizophrenia (PubMed:16641098). Participates in mRNA transport by regulating the nuclear export of MBP mRNA. Also involved in regulation of mRNA splicing of MAG pre-mRNA. Acts as a translational repressor (By similarity). {ECO:0000250|UniProtKB:Q9QYS9, ECO:0000269|PubMed:16641098, ECO:0000269|PubMed:23630077}.
Ensembl transtripts involved in fusion geneENST idsENST00000542669, ENST00000337019, 
ENST00000366888, ENST00000366889, 
ENST00000275262, ENST00000361195, 
ENST00000361752, ENST00000392127, 
ENST00000424802, ENST00000453779, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score3 X 3 X 2=1823 X 23 X 9=4761
# samples 427
** MAII scorelog2(4/18*10)=1.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(27/4761*10)=-4.14023331650551
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Fusion gene context

PubMed: PACRG [Title/Abstract] AND QKI [Title/Abstract] AND fusion [Title/Abstract]

Fusion neoantigen context

PubMed: PACRG [Title/Abstract] AND QKI [Title/Abstract] AND neoantigen [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)QKI(163899928)-PACRG(163483182), # samples:6
PACRG(163235313)-QKI(163983014), # samples:1
PACRG(163235313)-QKI(163899812), # samples:1
Anticipated loss of major functional domain due to fusion event.PACRG-QKI seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
PACRG-QKI seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
PACRG-QKI seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
PACRG-QKI seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
QKI-PACRG seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
QKI-PACRG seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
QKI-PACRG seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
QKI-PACRG seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
QKI-PACRG seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr6:163899928/chr6:163483182)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonRetention analysis results of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features, are available here.

check buttonFusion gene breakpoints across PACRG (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across QKI (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Amino Acid Sequences


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000337019PACRGchr6163235313+ENST00000275262QKIchr6163983014+6382515224946240
ENST00000337019PACRGchr6163235313+ENST00000392127QKIchr6163983014+7329515224928234
ENST00000337019PACRGchr6163235313+ENST00000453779QKIchr6163983014+5103515224928234
ENST00000337019PACRGchr6163235313+ENST00000361752QKIchr6163983014+8881515224994256
ENST00000337019PACRGchr6163235313+ENST00000361195QKIchr6163983014+1008515224970248
ENST00000337019PACRGchr6163235313+ENST00000424802QKIchr6163983014+923515224922233
ENST00000366889PACRGchr6163235313+ENST00000275262QKIchr6163983014+6382515224946240
ENST00000366889PACRGchr6163235313+ENST00000392127QKIchr6163983014+7329515224928234
ENST00000366889PACRGchr6163235313+ENST00000453779QKIchr6163983014+5103515224928234
ENST00000366889PACRGchr6163235313+ENST00000361752QKIchr6163983014+8881515224994256
ENST00000366889PACRGchr6163235313+ENST00000361195QKIchr6163983014+1008515224970248
ENST00000366889PACRGchr6163235313+ENST00000424802QKIchr6163983014+923515224922233
ENST00000366888PACRGchr6163235313+ENST00000275262QKIchr6163983014+6433566275997240
ENST00000366888PACRGchr6163235313+ENST00000392127QKIchr6163983014+7380566275979234
ENST00000366888PACRGchr6163235313+ENST00000453779QKIchr6163983014+5154566275979234
ENST00000366888PACRGchr6163235313+ENST00000361752QKIchr6163983014+89325662751045256
ENST00000366888PACRGchr6163235313+ENST00000361195QKIchr6163983014+10595662751021248
ENST00000366888PACRGchr6163235313+ENST00000424802QKIchr6163983014+974566275973233
ENST00000337019PACRGchr6163235313+ENST00000275262QKIchr6163899812+66435152241207327
ENST00000337019PACRGchr6163235313+ENST00000392127QKIchr6163899812+75905152241189321
ENST00000337019PACRGchr6163235313+ENST00000453779QKIchr6163899812+53645152241189321
ENST00000337019PACRGchr6163235313+ENST00000361752QKIchr6163899812+91425152241255343
ENST00000337019PACRGchr6163235313+ENST00000361195QKIchr6163899812+12695152241231335
ENST00000337019PACRGchr6163235313+ENST00000424802QKIchr6163899812+11845152241183320
ENST00000366889PACRGchr6163235313+ENST00000275262QKIchr6163899812+66435152241207327
ENST00000366889PACRGchr6163235313+ENST00000392127QKIchr6163899812+75905152241189321
ENST00000366889PACRGchr6163235313+ENST00000453779QKIchr6163899812+53645152241189321
ENST00000366889PACRGchr6163235313+ENST00000361752QKIchr6163899812+91425152241255343
ENST00000366889PACRGchr6163235313+ENST00000361195QKIchr6163899812+12695152241231335
ENST00000366889PACRGchr6163235313+ENST00000424802QKIchr6163899812+11845152241183320
ENST00000366888PACRGchr6163235313+ENST00000275262QKIchr6163899812+66945662751258327
ENST00000366888PACRGchr6163235313+ENST00000392127QKIchr6163899812+76415662751240321
ENST00000366888PACRGchr6163235313+ENST00000453779QKIchr6163899812+54155662751240321
ENST00000366888PACRGchr6163235313+ENST00000361752QKIchr6163899812+91935662751306343
ENST00000366888PACRGchr6163235313+ENST00000361195QKIchr6163899812+13205662751282335
ENST00000366888PACRGchr6163235313+ENST00000424802QKIchr6163899812+12355662751234320

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000337019ENST00000275262PACRGchr6163235313+QKIchr6163983014+0.001300440.99869955
ENST00000337019ENST00000392127PACRGchr6163235313+QKIchr6163983014+0.0012730760.9987269
ENST00000337019ENST00000453779PACRGchr6163235313+QKIchr6163983014+0.0012555140.9987445
ENST00000337019ENST00000361752PACRGchr6163235313+QKIchr6163983014+0.0008722540.9991278
ENST00000337019ENST00000361195PACRGchr6163235313+QKIchr6163983014+0.0229184650.9770815
ENST00000337019ENST00000424802PACRGchr6163235313+QKIchr6163983014+0.0113125490.9886875
ENST00000366889ENST00000275262PACRGchr6163235313+QKIchr6163983014+0.001300440.99869955
ENST00000366889ENST00000392127PACRGchr6163235313+QKIchr6163983014+0.0012730760.9987269
ENST00000366889ENST00000453779PACRGchr6163235313+QKIchr6163983014+0.0012555140.9987445
ENST00000366889ENST00000361752PACRGchr6163235313+QKIchr6163983014+0.0008722540.9991278
ENST00000366889ENST00000361195PACRGchr6163235313+QKIchr6163983014+0.0229184650.9770815
ENST00000366889ENST00000424802PACRGchr6163235313+QKIchr6163983014+0.0113125490.9886875
ENST00000366888ENST00000275262PACRGchr6163235313+QKIchr6163983014+0.001281390.9987186
ENST00000366888ENST00000392127PACRGchr6163235313+QKIchr6163983014+0.001252160.9987478
ENST00000366888ENST00000453779PACRGchr6163235313+QKIchr6163983014+0.0012173590.9987827
ENST00000366888ENST00000361752PACRGchr6163235313+QKIchr6163983014+0.0008597440.99914026
ENST00000366888ENST00000361195PACRGchr6163235313+QKIchr6163983014+0.01657670.98342335
ENST00000366888ENST00000424802PACRGchr6163235313+QKIchr6163983014+0.0086240280.991376
ENST00000337019ENST00000275262PACRGchr6163235313+QKIchr6163899812+0.0002256130.9997744
ENST00000337019ENST00000392127PACRGchr6163235313+QKIchr6163899812+0.000223890.99977607
ENST00000337019ENST00000453779PACRGchr6163235313+QKIchr6163899812+0.0002448320.9997552
ENST00000337019ENST00000361752PACRGchr6163235313+QKIchr6163899812+0.000166780.9998332
ENST00000337019ENST00000361195PACRGchr6163235313+QKIchr6163899812+0.0071705920.9928294
ENST00000337019ENST00000424802PACRGchr6163235313+QKIchr6163899812+0.0066508430.99334913
ENST00000366889ENST00000275262PACRGchr6163235313+QKIchr6163899812+0.0002256130.9997744
ENST00000366889ENST00000392127PACRGchr6163235313+QKIchr6163899812+0.000223890.99977607
ENST00000366889ENST00000453779PACRGchr6163235313+QKIchr6163899812+0.0002448320.9997552
ENST00000366889ENST00000361752PACRGchr6163235313+QKIchr6163899812+0.000166780.9998332
ENST00000366889ENST00000361195PACRGchr6163235313+QKIchr6163899812+0.0071705920.9928294
ENST00000366889ENST00000424802PACRGchr6163235313+QKIchr6163899812+0.0066508430.99334913
ENST00000366888ENST00000275262PACRGchr6163235313+QKIchr6163899812+0.0002250090.999775
ENST00000366888ENST00000392127PACRGchr6163235313+QKIchr6163899812+0.000223450.99977654
ENST00000366888ENST00000453779PACRGchr6163235313+QKIchr6163899812+0.0002440320.9997559
ENST00000366888ENST00000361752PACRGchr6163235313+QKIchr6163899812+0.0001637620.9998362
ENST00000366888ENST00000361195PACRGchr6163235313+QKIchr6163899812+0.0066406540.9933594
ENST00000366888ENST00000424802PACRGchr6163235313+QKIchr6163899812+0.0064507240.9935493

check button Predicted full-length fusion amino acid sequences. For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among all the predicted ones.

Get the fusion protein sequences from here.

Fusion protein sequence information is available in the fasta format.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

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Fusion Protein Breakpoint Sequences for PACRG-QKI

check button +/-13 AA sequence from the breakpoints of the fusion protein sequences.
HgeneHchrHbpTgeneTchrTbpLength(fusion protein)BP in fusion proteinPeptide
PACRGchr6163235313QKIchr616389981251597LEHDSKGNKIAWKFNFVGRILGPRGL
PACRGchr6163235313QKIchr616389981256697LEHDSKGNKIAWKFNFVGRILGPRGL
PACRGchr6163235313QKIchr616398301451597LEHDSKGNKIAWKAEGEDSLKKMQLM
PACRGchr6163235313QKIchr616398301456697LEHDSKGNKIAWKAEGEDSLKKMQLM

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Potential FusionNeoAntigen Information of PACRG-QKI in HLA I

check button Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.
PACRG-QKI_163235313_163899812.msa
PACRG-QKI_163235313_163983014.msa

check button Potential FusionNeoAntigen Information
* We used NetMHCpan v4.1 (%rank<0.5) and deepHLApan v1.1 (immunogenic score>0.5)
Fusion geneHchrHbpTgeneTchrTbpHLA IFusionNeoAntigen peptideBinding scoreImmunogenic scoreNeoantigen start (at BP 13)Neoantigen end (at BP 13)
PACRG-QKIchr6163235313chr6163899812515HLA-B57:01KGNKIAWKF0.99320.9092514
PACRG-QKIchr6163235313chr6163899812515HLA-B58:02KGNKIAWKF0.9860.8904514
PACRG-QKIchr6163235313chr6163899812515HLA-B57:03KGNKIAWKF0.96440.9237514
PACRG-QKIchr6163235313chr6163899812515HLA-B58:01KGNKIAWKF0.95560.8211514
PACRG-QKIchr6163235313chr6163899812515HLA-A31:02AWKFNFVGR0.87220.75361019
PACRG-QKIchr6163235313chr6163899812515HLA-A32:13KGNKIAWKF0.7430.8861514
PACRG-QKIchr6163235313chr6163899812515HLA-A31:01AWKFNFVGR0.93180.71111019
PACRG-QKIchr6163235313chr6163899812515HLA-A31:01KIAWKFNFVGR0.98810.5379819
PACRG-QKIchr6163235313chr6163899812515HLA-B57:10KGNKIAWKF0.99320.9092514
PACRG-QKIchr6163235313chr6163899812515HLA-B58:06KGNKIAWKF0.97070.7811514
PACRG-QKIchr6163235313chr6163899812515HLA-B57:04KGNKIAWKF0.8940.7748514
PACRG-QKIchr6163235313chr6163899812515HLA-A32:01KGNKIAWKF0.88990.873514
PACRG-QKIchr6163235313chr6163899812515HLA-B57:02KGNKIAWKF0.71830.9449514
PACRG-QKIchr6163235313chr6163899812515HLA-C06:06KFNFVGRIL0.20340.97081221
PACRG-QKIchr6163235313chr6163899812515HLA-C14:02KFNFVGRIL0.16580.86131221
PACRG-QKIchr6163235313chr6163899812515HLA-C14:03KFNFVGRIL0.16580.86131221
PACRG-QKIchr6163235313chr6163983014515HLA-B39:01WKAEGEDSL0.98720.96341120
PACRG-QKIchr6163235313chr6163983014515HLA-B38:02WKAEGEDSL0.97780.98371120
PACRG-QKIchr6163235313chr6163983014515HLA-B38:01WKAEGEDSL0.97490.98221120
PACRG-QKIchr6163235313chr6163983014515HLA-B39:13WKAEGEDSL0.97310.97571120
PACRG-QKIchr6163235313chr6163983014515HLA-B39:24WKAEGEDSL0.94360.5051120
PACRG-QKIchr6163235313chr6163983014515HLA-B15:10WKAEGEDSL0.69910.85391120
PACRG-QKIchr6163235313chr6163983014515HLA-B15:37WKAEGEDSL0.28770.86931120
PACRG-QKIchr6163235313chr6163983014515HLA-B48:01WKAEGEDSL0.27420.76821120
PACRG-QKIchr6163235313chr6163983014515HLA-B39:09WKAEGEDSL0.9910.72221120
PACRG-QKIchr6163235313chr6163983014515HLA-B39:05WKAEGEDSL0.97780.95751120
PACRG-QKIchr6163235313chr6163983014515HLA-B39:08WKAEGEDSL0.46520.87521120
PACRG-QKIchr6163235313chr6163983014515HLA-B48:03WKAEGEDSL0.05080.60271120
PACRG-QKIchr6163235313chr6163983014515HLA-B39:31WKAEGEDSL0.98720.96391120
PACRG-QKIchr6163235313chr6163983014515HLA-B39:02WKAEGEDSL0.98660.97441120
PACRG-QKIchr6163235313chr6163983014515HLA-B38:05WKAEGEDSL0.97490.98221120
PACRG-QKIchr6163235313chr6163983014515HLA-B15:09WKAEGEDSL0.63850.8541120
PACRG-QKIchr6163235313chr6163983014515HLA-B39:11WKAEGEDSL0.48580.85011120
PACRG-QKIchr6163235313chr6163983014515HLA-B40:12WKAEGEDSL0.05080.60271120

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Potential FusionNeoAntigen Information of PACRG-QKI in HLA II

check button Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.
PACRG-QKI_163235313_163899812.msa
PACRG-QKI_163235313_163983014.msa

check button Potential FusionNeoAntigen Information
* We used NetMHCIIpan v4.1 (%rank<0.5).
Fusion geneHchrHbpTgeneTchrTbpHLA IIFusionNeoAntigen peptideNeoantigen start (at BP 13)Neoantigen end (at BP 13)
PACRG-QKIchr6163235313chr6163899812515DRB1-0802AWKFNFVGRILGPRG1025
PACRG-QKIchr6163235313chr6163899812515DRB1-0802IAWKFNFVGRILGPR924
PACRG-QKIchr6163235313chr6163899812515DRB1-0802WKFNFVGRILGPRGL1126
PACRG-QKIchr6163235313chr6163899812515DRB1-0803AWKFNFVGRILGPRG1025
PACRG-QKIchr6163235313chr6163899812515DRB1-0807AWKFNFVGRILGPRG1025
PACRG-QKIchr6163235313chr6163899812515DRB1-0808AWKFNFVGRILGPRG1025
PACRG-QKIchr6163235313chr6163899812515DRB1-0808IAWKFNFVGRILGPR924
PACRG-QKIchr6163235313chr6163899812515DRB1-0809AWKFNFVGRILGPRG1025
PACRG-QKIchr6163235313chr6163899812515DRB1-0809IAWKFNFVGRILGPR924
PACRG-QKIchr6163235313chr6163899812515DRB1-0809WKFNFVGRILGPRGL1126
PACRG-QKIchr6163235313chr6163899812515DRB1-0811AWKFNFVGRILGPRG1025
PACRG-QKIchr6163235313chr6163899812515DRB1-0811IAWKFNFVGRILGPR924
PACRG-QKIchr6163235313chr6163899812515DRB1-0813AWKFNFVGRILGPRG1025
PACRG-QKIchr6163235313chr6163899812515DRB1-0813IAWKFNFVGRILGPR924
PACRG-QKIchr6163235313chr6163899812515DRB1-0814AWKFNFVGRILGPRG1025
PACRG-QKIchr6163235313chr6163899812515DRB1-0815AWKFNFVGRILGPRG1025
PACRG-QKIchr6163235313chr6163899812515DRB1-0815IAWKFNFVGRILGPR924
PACRG-QKIchr6163235313chr6163899812515DRB1-0821AWKFNFVGRILGPRG1025
PACRG-QKIchr6163235313chr6163899812515DRB1-0821IAWKFNFVGRILGPR924
PACRG-QKIchr6163235313chr6163899812515DRB1-0821WKFNFVGRILGPRGL1126
PACRG-QKIchr6163235313chr6163899812515DRB1-0823AWKFNFVGRILGPRG1025
PACRG-QKIchr6163235313chr6163899812515DRB1-0824AWKFNFVGRILGPRG1025
PACRG-QKIchr6163235313chr6163899812515DRB1-0824IAWKFNFVGRILGPR924
PACRG-QKIchr6163235313chr6163899812515DRB1-0824WKFNFVGRILGPRGL1126
PACRG-QKIchr6163235313chr6163899812515DRB1-0827AWKFNFVGRILGPRG1025
PACRG-QKIchr6163235313chr6163899812515DRB1-0830AWKFNFVGRILGPRG1025
PACRG-QKIchr6163235313chr6163899812515DRB1-0830IAWKFNFVGRILGPR924
PACRG-QKIchr6163235313chr6163899812515DRB1-0833AWKFNFVGRILGPRG1025
PACRG-QKIchr6163235313chr6163899812515DRB1-0835AWKFNFVGRILGPRG1025
PACRG-QKIchr6163235313chr6163899812515DRB1-0836AWKFNFVGRILGPRG1025
PACRG-QKIchr6163235313chr6163899812515DRB1-0837AWKFNFVGRILGPRG1025
PACRG-QKIchr6163235313chr6163899812515DRB1-0837IAWKFNFVGRILGPR924
PACRG-QKIchr6163235313chr6163899812515DRB1-0838AWKFNFVGRILGPRG1025
PACRG-QKIchr6163235313chr6163899812515DRB1-1101AWKFNFVGRILGPRG1025
PACRG-QKIchr6163235313chr6163899812515DRB1-1101IAWKFNFVGRILGPR924
PACRG-QKIchr6163235313chr6163899812515DRB1-1101WKFNFVGRILGPRGL1126
PACRG-QKIchr6163235313chr6163899812515DRB1-1101KIAWKFNFVGRILGP823
PACRG-QKIchr6163235313chr6163899812515DRB1-1105AWKFNFVGRILGPRG1025
PACRG-QKIchr6163235313chr6163899812515DRB1-1105IAWKFNFVGRILGPR924
PACRG-QKIchr6163235313chr6163899812515DRB1-1105WKFNFVGRILGPRGL1126
PACRG-QKIchr6163235313chr6163899812515DRB1-1105KIAWKFNFVGRILGP823
PACRG-QKIchr6163235313chr6163899812515DRB1-1108AWKFNFVGRILGPRG1025
PACRG-QKIchr6163235313chr6163899812515DRB1-1108IAWKFNFVGRILGPR924
PACRG-QKIchr6163235313chr6163899812515DRB1-1108WKFNFVGRILGPRGL1126
PACRG-QKIchr6163235313chr6163899812515DRB1-1108KIAWKFNFVGRILGP823
PACRG-QKIchr6163235313chr6163899812515DRB1-1109AWKFNFVGRILGPRG1025
PACRG-QKIchr6163235313chr6163899812515DRB1-1109IAWKFNFVGRILGPR924
PACRG-QKIchr6163235313chr6163899812515DRB1-1109WKFNFVGRILGPRGL1126
PACRG-QKIchr6163235313chr6163899812515DRB1-1109KIAWKFNFVGRILGP823
PACRG-QKIchr6163235313chr6163899812515DRB1-1110AWKFNFVGRILGPRG1025
PACRG-QKIchr6163235313chr6163899812515DRB1-1110IAWKFNFVGRILGPR924
PACRG-QKIchr6163235313chr6163899812515DRB1-1110WKFNFVGRILGPRGL1126
PACRG-QKIchr6163235313chr6163899812515DRB1-1110KIAWKFNFVGRILGP823
PACRG-QKIchr6163235313chr6163899812515DRB1-1111AWKFNFVGRILGPRG1025
PACRG-QKIchr6163235313chr6163899812515DRB1-1112AWKFNFVGRILGPRG1025
PACRG-QKIchr6163235313chr6163899812515DRB1-1112IAWKFNFVGRILGPR924
PACRG-QKIchr6163235313chr6163899812515DRB1-1112WKFNFVGRILGPRGL1126
PACRG-QKIchr6163235313chr6163899812515DRB1-1112KIAWKFNFVGRILGP823
PACRG-QKIchr6163235313chr6163899812515DRB1-1115AWKFNFVGRILGPRG1025
PACRG-QKIchr6163235313chr6163899812515DRB1-1115IAWKFNFVGRILGPR924
PACRG-QKIchr6163235313chr6163899812515DRB1-1115WKFNFVGRILGPRGL1126
PACRG-QKIchr6163235313chr6163899812515DRB1-1115KIAWKFNFVGRILGP823
PACRG-QKIchr6163235313chr6163899812515DRB1-1119AWKFNFVGRILGPRG1025
PACRG-QKIchr6163235313chr6163899812515DRB1-1119IAWKFNFVGRILGPR924
PACRG-QKIchr6163235313chr6163899812515DRB1-1119WKFNFVGRILGPRGL1126
PACRG-QKIchr6163235313chr6163899812515DRB1-1119KIAWKFNFVGRILGP823
PACRG-QKIchr6163235313chr6163899812515DRB1-1124AWKFNFVGRILGPRG1025
PACRG-QKIchr6163235313chr6163899812515DRB1-1124IAWKFNFVGRILGPR924
PACRG-QKIchr6163235313chr6163899812515DRB1-1124WKFNFVGRILGPRGL1126
PACRG-QKIchr6163235313chr6163899812515DRB1-1124KIAWKFNFVGRILGP823
PACRG-QKIchr6163235313chr6163899812515DRB1-1127AWKFNFVGRILGPRG1025
PACRG-QKIchr6163235313chr6163899812515DRB1-1127IAWKFNFVGRILGPR924
PACRG-QKIchr6163235313chr6163899812515DRB1-1127WKFNFVGRILGPRGL1126
PACRG-QKIchr6163235313chr6163899812515DRB1-1127KIAWKFNFVGRILGP823
PACRG-QKIchr6163235313chr6163899812515DRB1-1128AWKFNFVGRILGPRG1025
PACRG-QKIchr6163235313chr6163899812515DRB1-1128IAWKFNFVGRILGPR924
PACRG-QKIchr6163235313chr6163899812515DRB1-1128WKFNFVGRILGPRGL1126
PACRG-QKIchr6163235313chr6163899812515DRB1-1128KIAWKFNFVGRILGP823
PACRG-QKIchr6163235313chr6163899812515DRB1-1129AWKFNFVGRILGPRG1025
PACRG-QKIchr6163235313chr6163899812515DRB1-1129IAWKFNFVGRILGPR924
PACRG-QKIchr6163235313chr6163899812515DRB1-1129WKFNFVGRILGPRGL1126
PACRG-QKIchr6163235313chr6163899812515DRB1-1129KIAWKFNFVGRILGP823
PACRG-QKIchr6163235313chr6163899812515DRB1-1130AWKFNFVGRILGPRG1025
PACRG-QKIchr6163235313chr6163899812515DRB1-1131AWKFNFVGRILGPRG1025
PACRG-QKIchr6163235313chr6163899812515DRB1-1131IAWKFNFVGRILGPR924
PACRG-QKIchr6163235313chr6163899812515DRB1-1131WKFNFVGRILGPRGL1126
PACRG-QKIchr6163235313chr6163899812515DRB1-1131KIAWKFNFVGRILGP823
PACRG-QKIchr6163235313chr6163899812515DRB1-1132AWKFNFVGRILGPRG1025
PACRG-QKIchr6163235313chr6163899812515DRB1-1132IAWKFNFVGRILGPR924
PACRG-QKIchr6163235313chr6163899812515DRB1-1132WKFNFVGRILGPRGL1126
PACRG-QKIchr6163235313chr6163899812515DRB1-1133AWKFNFVGRILGPRG1025
PACRG-QKIchr6163235313chr6163899812515DRB1-1133IAWKFNFVGRILGPR924
PACRG-QKIchr6163235313chr6163899812515DRB1-1133WKFNFVGRILGPRGL1126
PACRG-QKIchr6163235313chr6163899812515DRB1-1133KIAWKFNFVGRILGP823
PACRG-QKIchr6163235313chr6163899812515DRB1-1137AWKFNFVGRILGPRG1025
PACRG-QKIchr6163235313chr6163899812515DRB1-1137IAWKFNFVGRILGPR924
PACRG-QKIchr6163235313chr6163899812515DRB1-1137WKFNFVGRILGPRGL1126
PACRG-QKIchr6163235313chr6163899812515DRB1-1139AWKFNFVGRILGPRG1025
PACRG-QKIchr6163235313chr6163899812515DRB1-1139IAWKFNFVGRILGPR924
PACRG-QKIchr6163235313chr6163899812515DRB1-1139WKFNFVGRILGPRGL1126
PACRG-QKIchr6163235313chr6163899812515DRB1-1139KIAWKFNFVGRILGP823
PACRG-QKIchr6163235313chr6163899812515DRB1-1145AWKFNFVGRILGPRG1025
PACRG-QKIchr6163235313chr6163899812515DRB1-1145IAWKFNFVGRILGPR924
PACRG-QKIchr6163235313chr6163899812515DRB1-1145WKFNFVGRILGPRGL1126
PACRG-QKIchr6163235313chr6163899812515DRB1-1149AWKFNFVGRILGPRG1025
PACRG-QKIchr6163235313chr6163899812515DRB1-1149IAWKFNFVGRILGPR924
PACRG-QKIchr6163235313chr6163899812515DRB1-1149WKFNFVGRILGPRGL1126
PACRG-QKIchr6163235313chr6163899812515DRB1-1149KIAWKFNFVGRILGP823
PACRG-QKIchr6163235313chr6163899812515DRB1-1151AWKFNFVGRILGPRG1025
PACRG-QKIchr6163235313chr6163899812515DRB1-1151IAWKFNFVGRILGPR924
PACRG-QKIchr6163235313chr6163899812515DRB1-1151WKFNFVGRILGPRGL1126
PACRG-QKIchr6163235313chr6163899812515DRB1-1151KIAWKFNFVGRILGP823
PACRG-QKIchr6163235313chr6163899812515DRB1-1153AWKFNFVGRILGPRG1025
PACRG-QKIchr6163235313chr6163899812515DRB1-1153IAWKFNFVGRILGPR924
PACRG-QKIchr6163235313chr6163899812515DRB1-1161AWKFNFVGRILGPRG1025
PACRG-QKIchr6163235313chr6163899812515DRB1-1161IAWKFNFVGRILGPR924
PACRG-QKIchr6163235313chr6163899812515DRB1-1161WKFNFVGRILGPRGL1126
PACRG-QKIchr6163235313chr6163899812515DRB1-1161KIAWKFNFVGRILGP823
PACRG-QKIchr6163235313chr6163899812515DRB1-1162AWKFNFVGRILGPRG1025
PACRG-QKIchr6163235313chr6163899812515DRB1-1162IAWKFNFVGRILGPR924
PACRG-QKIchr6163235313chr6163899812515DRB1-1162WKFNFVGRILGPRGL1126
PACRG-QKIchr6163235313chr6163899812515DRB1-1162KIAWKFNFVGRILGP823
PACRG-QKIchr6163235313chr6163899812515DRB1-1164AWKFNFVGRILGPRG1025
PACRG-QKIchr6163235313chr6163899812515DRB1-1164IAWKFNFVGRILGPR924
PACRG-QKIchr6163235313chr6163899812515DRB1-1164WKFNFVGRILGPRGL1126
PACRG-QKIchr6163235313chr6163899812515DRB1-1166AWKFNFVGRILGPRG1025
PACRG-QKIchr6163235313chr6163899812515DRB1-1166IAWKFNFVGRILGPR924
PACRG-QKIchr6163235313chr6163899812515DRB1-1166WKFNFVGRILGPRGL1126
PACRG-QKIchr6163235313chr6163899812515DRB1-1166KIAWKFNFVGRILGP823
PACRG-QKIchr6163235313chr6163899812515DRB1-1169AWKFNFVGRILGPRG1025
PACRG-QKIchr6163235313chr6163899812515DRB1-1169IAWKFNFVGRILGPR924
PACRG-QKIchr6163235313chr6163899812515DRB1-1169WKFNFVGRILGPRGL1126
PACRG-QKIchr6163235313chr6163899812515DRB1-1172AWKFNFVGRILGPRG1025
PACRG-QKIchr6163235313chr6163899812515DRB1-1172IAWKFNFVGRILGPR924
PACRG-QKIchr6163235313chr6163899812515DRB1-1173AWKFNFVGRILGPRG1025
PACRG-QKIchr6163235313chr6163899812515DRB1-1173IAWKFNFVGRILGPR924
PACRG-QKIchr6163235313chr6163899812515DRB1-1173WKFNFVGRILGPRGL1126
PACRG-QKIchr6163235313chr6163899812515DRB1-1174AWKFNFVGRILGPRG1025
PACRG-QKIchr6163235313chr6163899812515DRB1-1174IAWKFNFVGRILGPR924
PACRG-QKIchr6163235313chr6163899812515DRB1-1174WKFNFVGRILGPRGL1126
PACRG-QKIchr6163235313chr6163899812515DRB1-1174KIAWKFNFVGRILGP823
PACRG-QKIchr6163235313chr6163899812515DRB1-1175AWKFNFVGRILGPRG1025
PACRG-QKIchr6163235313chr6163899812515DRB1-1175IAWKFNFVGRILGPR924
PACRG-QKIchr6163235313chr6163899812515DRB1-1175WKFNFVGRILGPRGL1126
PACRG-QKIchr6163235313chr6163899812515DRB1-1175KIAWKFNFVGRILGP823
PACRG-QKIchr6163235313chr6163899812515DRB1-1179AWKFNFVGRILGPRG1025
PACRG-QKIchr6163235313chr6163899812515DRB1-1180AWKFNFVGRILGPRG1025
PACRG-QKIchr6163235313chr6163899812515DRB1-1180IAWKFNFVGRILGPR924
PACRG-QKIchr6163235313chr6163899812515DRB1-1180WKFNFVGRILGPRGL1126
PACRG-QKIchr6163235313chr6163899812515DRB1-1180KIAWKFNFVGRILGP823
PACRG-QKIchr6163235313chr6163899812515DRB1-1181AWKFNFVGRILGPRG1025
PACRG-QKIchr6163235313chr6163899812515DRB1-1181IAWKFNFVGRILGPR924
PACRG-QKIchr6163235313chr6163899812515DRB1-1181WKFNFVGRILGPRGL1126
PACRG-QKIchr6163235313chr6163899812515DRB1-1181KIAWKFNFVGRILGP823
PACRG-QKIchr6163235313chr6163899812515DRB1-1182AWKFNFVGRILGPRG1025
PACRG-QKIchr6163235313chr6163899812515DRB1-1182IAWKFNFVGRILGPR924
PACRG-QKIchr6163235313chr6163899812515DRB1-1187AWKFNFVGRILGPRG1025
PACRG-QKIchr6163235313chr6163899812515DRB1-1187IAWKFNFVGRILGPR924
PACRG-QKIchr6163235313chr6163899812515DRB1-1187WKFNFVGRILGPRGL1126
PACRG-QKIchr6163235313chr6163899812515DRB1-1187KIAWKFNFVGRILGP823
PACRG-QKIchr6163235313chr6163899812515DRB1-1190AWKFNFVGRILGPRG1025
PACRG-QKIchr6163235313chr6163899812515DRB1-1190IAWKFNFVGRILGPR924
PACRG-QKIchr6163235313chr6163899812515DRB1-1190WKFNFVGRILGPRGL1126
PACRG-QKIchr6163235313chr6163899812515DRB1-1190KIAWKFNFVGRILGP823
PACRG-QKIchr6163235313chr6163899812515DRB1-1191AWKFNFVGRILGPRG1025
PACRG-QKIchr6163235313chr6163899812515DRB1-1191IAWKFNFVGRILGPR924
PACRG-QKIchr6163235313chr6163899812515DRB1-1191WKFNFVGRILGPRGL1126
PACRG-QKIchr6163235313chr6163899812515DRB1-1191KIAWKFNFVGRILGP823
PACRG-QKIchr6163235313chr6163899812515DRB1-1193AWKFNFVGRILGPRG1025
PACRG-QKIchr6163235313chr6163899812515DRB1-1193IAWKFNFVGRILGPR924
PACRG-QKIchr6163235313chr6163899812515DRB1-1193WKFNFVGRILGPRGL1126
PACRG-QKIchr6163235313chr6163899812515DRB1-1194AWKFNFVGRILGPRG1025
PACRG-QKIchr6163235313chr6163899812515DRB1-1194IAWKFNFVGRILGPR924
PACRG-QKIchr6163235313chr6163899812515DRB1-1194WKFNFVGRILGPRGL1126
PACRG-QKIchr6163235313chr6163899812515DRB1-1194KIAWKFNFVGRILGP823
PACRG-QKIchr6163235313chr6163899812515DRB1-1195AWKFNFVGRILGPRG1025
PACRG-QKIchr6163235313chr6163899812515DRB1-1195IAWKFNFVGRILGPR924
PACRG-QKIchr6163235313chr6163899812515DRB1-1195WKFNFVGRILGPRGL1126
PACRG-QKIchr6163235313chr6163899812515DRB1-1195KIAWKFNFVGRILGP823
PACRG-QKIchr6163235313chr6163899812515DRB1-1196AWKFNFVGRILGPRG1025
PACRG-QKIchr6163235313chr6163899812515DRB1-1196IAWKFNFVGRILGPR924
PACRG-QKIchr6163235313chr6163899812515DRB1-1196WKFNFVGRILGPRGL1126
PACRG-QKIchr6163235313chr6163899812515DRB1-1196KIAWKFNFVGRILGP823
PACRG-QKIchr6163235313chr6163899812515DRB1-1305AWKFNFVGRILGPRG1025
PACRG-QKIchr6163235313chr6163899812515DRB1-1305IAWKFNFVGRILGPR924
PACRG-QKIchr6163235313chr6163899812515DRB1-1305WKFNFVGRILGPRGL1126
PACRG-QKIchr6163235313chr6163899812515DRB1-1305KIAWKFNFVGRILGP823
PACRG-QKIchr6163235313chr6163899812515DRB1-1307AWKFNFVGRILGPRG1025
PACRG-QKIchr6163235313chr6163899812515DRB1-1307IAWKFNFVGRILGPR924
PACRG-QKIchr6163235313chr6163899812515DRB1-1307WKFNFVGRILGPRGL1126
PACRG-QKIchr6163235313chr6163899812515DRB1-13100AWKFNFVGRILGPRG1025
PACRG-QKIchr6163235313chr6163899812515DRB1-13100IAWKFNFVGRILGPR924
PACRG-QKIchr6163235313chr6163899812515DRB1-1313AWKFNFVGRILGPRG1025
PACRG-QKIchr6163235313chr6163899812515DRB1-1314AWKFNFVGRILGPRG1025
PACRG-QKIchr6163235313chr6163899812515DRB1-1314IAWKFNFVGRILGPR924
PACRG-QKIchr6163235313chr6163899812515DRB1-1314WKFNFVGRILGPRGL1126
PACRG-QKIchr6163235313chr6163899812515DRB1-1314KIAWKFNFVGRILGP823
PACRG-QKIchr6163235313chr6163899812515DRB1-1321AWKFNFVGRILGPRG1025
PACRG-QKIchr6163235313chr6163899812515DRB1-1326AWKFNFVGRILGPRG1025
PACRG-QKIchr6163235313chr6163899812515DRB1-1326IAWKFNFVGRILGPR924
PACRG-QKIchr6163235313chr6163899812515DRB1-1326WKFNFVGRILGPRGL1126
PACRG-QKIchr6163235313chr6163899812515DRB1-1330AWKFNFVGRILGPRG1025
PACRG-QKIchr6163235313chr6163899812515DRB1-1330IAWKFNFVGRILGPR924
PACRG-QKIchr6163235313chr6163899812515DRB1-1337AWKFNFVGRILGPRG1025
PACRG-QKIchr6163235313chr6163899812515DRB1-1337IAWKFNFVGRILGPR924
PACRG-QKIchr6163235313chr6163899812515DRB1-1346AWKFNFVGRILGPRG1025
PACRG-QKIchr6163235313chr6163899812515DRB1-1346IAWKFNFVGRILGPR924
PACRG-QKIchr6163235313chr6163899812515DRB1-1347AWKFNFVGRILGPRG1025
PACRG-QKIchr6163235313chr6163899812515DRB1-1347IAWKFNFVGRILGPR924
PACRG-QKIchr6163235313chr6163899812515DRB1-1347WKFNFVGRILGPRGL1126
PACRG-QKIchr6163235313chr6163899812515DRB1-1350AWKFNFVGRILGPRG1025
PACRG-QKIchr6163235313chr6163899812515DRB1-1350IAWKFNFVGRILGPR924
PACRG-QKIchr6163235313chr6163899812515DRB1-1350WKFNFVGRILGPRGL1126
PACRG-QKIchr6163235313chr6163899812515DRB1-1350KIAWKFNFVGRILGP823
PACRG-QKIchr6163235313chr6163899812515DRB1-1356AWKFNFVGRILGPRG1025
PACRG-QKIchr6163235313chr6163899812515DRB1-1356IAWKFNFVGRILGPR924
PACRG-QKIchr6163235313chr6163899812515DRB1-1356WKFNFVGRILGPRGL1126
PACRG-QKIchr6163235313chr6163899812515DRB1-1356KIAWKFNFVGRILGP823
PACRG-QKIchr6163235313chr6163899812515DRB1-1360AWKFNFVGRILGPRG1025
PACRG-QKIchr6163235313chr6163899812515DRB1-1360IAWKFNFVGRILGPR924
PACRG-QKIchr6163235313chr6163899812515DRB1-1360WKFNFVGRILGPRGL1126
PACRG-QKIchr6163235313chr6163899812515DRB1-1362AWKFNFVGRILGPRG1025
PACRG-QKIchr6163235313chr6163899812515DRB1-1362IAWKFNFVGRILGPR924
PACRG-QKIchr6163235313chr6163899812515DRB1-1362WKFNFVGRILGPRGL1126
PACRG-QKIchr6163235313chr6163899812515DRB1-1362KIAWKFNFVGRILGP823
PACRG-QKIchr6163235313chr6163899812515DRB1-1363AWKFNFVGRILGPRG1025
PACRG-QKIchr6163235313chr6163899812515DRB1-1382AWKFNFVGRILGPRG1025
PACRG-QKIchr6163235313chr6163899812515DRB1-1382IAWKFNFVGRILGPR924
PACRG-QKIchr6163235313chr6163899812515DRB1-1382WKFNFVGRILGPRGL1126
PACRG-QKIchr6163235313chr6163899812515DRB1-1382KIAWKFNFVGRILGP823
PACRG-QKIchr6163235313chr6163899812515DRB1-1385AWKFNFVGRILGPRG1025
PACRG-QKIchr6163235313chr6163899812515DRB1-1385IAWKFNFVGRILGPR924
PACRG-QKIchr6163235313chr6163899812515DRB1-1386AWKFNFVGRILGPRG1025
PACRG-QKIchr6163235313chr6163899812515DRB1-1386IAWKFNFVGRILGPR924
PACRG-QKIchr6163235313chr6163899812515DRB1-1402AWKFNFVGRILGPRG1025
PACRG-QKIchr6163235313chr6163899812515DRB1-1403AWKFNFVGRILGPRG1025
PACRG-QKIchr6163235313chr6163899812515DRB1-1403IAWKFNFVGRILGPR924
PACRG-QKIchr6163235313chr6163899812515DRB1-1403WKFNFVGRILGPRGL1126
PACRG-QKIchr6163235313chr6163899812515DRB1-1409AWKFNFVGRILGPRG1025
PACRG-QKIchr6163235313chr6163899812515DRB1-1409IAWKFNFVGRILGPR924
PACRG-QKIchr6163235313chr6163899812515DRB1-1414AWKFNFVGRILGPRG1025
PACRG-QKIchr6163235313chr6163899812515DRB1-1414IAWKFNFVGRILGPR924
PACRG-QKIchr6163235313chr6163899812515DRB1-1422AWKFNFVGRILGPRG1025
PACRG-QKIchr6163235313chr6163899812515DRB1-1422IAWKFNFVGRILGPR924
PACRG-QKIchr6163235313chr6163899812515DRB1-1424AWKFNFVGRILGPRG1025
PACRG-QKIchr6163235313chr6163899812515DRB1-1425AWKFNFVGRILGPRG1025
PACRG-QKIchr6163235313chr6163899812515DRB1-1425IAWKFNFVGRILGPR924
PACRG-QKIchr6163235313chr6163899812515DRB1-1427AWKFNFVGRILGPRG1025
PACRG-QKIchr6163235313chr6163899812515DRB1-1427IAWKFNFVGRILGPR924
PACRG-QKIchr6163235313chr6163899812515DRB1-1427WKFNFVGRILGPRGL1126
PACRG-QKIchr6163235313chr6163899812515DRB1-1430AWKFNFVGRILGPRG1025
PACRG-QKIchr6163235313chr6163899812515DRB1-1430IAWKFNFVGRILGPR924
PACRG-QKIchr6163235313chr6163899812515DRB1-1436AWKFNFVGRILGPRG1025
PACRG-QKIchr6163235313chr6163899812515DRB1-1436IAWKFNFVGRILGPR924
PACRG-QKIchr6163235313chr6163899812515DRB1-1440AWKFNFVGRILGPRG1025
PACRG-QKIchr6163235313chr6163899812515DRB1-1440IAWKFNFVGRILGPR924
PACRG-QKIchr6163235313chr6163899812515DRB1-1440WKFNFVGRILGPRGL1126
PACRG-QKIchr6163235313chr6163899812515DRB1-1441AWKFNFVGRILGPRG1025
PACRG-QKIchr6163235313chr6163899812515DRB1-1442AWKFNFVGRILGPRG1025
PACRG-QKIchr6163235313chr6163899812515DRB1-1442IAWKFNFVGRILGPR924
PACRG-QKIchr6163235313chr6163899812515DRB1-1442KIAWKFNFVGRILGP823
PACRG-QKIchr6163235313chr6163899812515DRB1-1444AWKFNFVGRILGPRG1025
PACRG-QKIchr6163235313chr6163899812515DRB1-1444IAWKFNFVGRILGPR924
PACRG-QKIchr6163235313chr6163899812515DRB1-1451AWKFNFVGRILGPRG1025
PACRG-QKIchr6163235313chr6163899812515DRB1-1453AWKFNFVGRILGPRG1025
PACRG-QKIchr6163235313chr6163899812515DRB1-1453IAWKFNFVGRILGPR924
PACRG-QKIchr6163235313chr6163899812515DRB1-1463AWKFNFVGRILGPRG1025
PACRG-QKIchr6163235313chr6163899812515DRB1-1463IAWKFNFVGRILGPR924
PACRG-QKIchr6163235313chr6163899812515DRB1-1467AWKFNFVGRILGPRG1025
PACRG-QKIchr6163235313chr6163899812515DRB1-1467IAWKFNFVGRILGPR924
PACRG-QKIchr6163235313chr6163899812515DRB1-1467WKFNFVGRILGPRGL1126
PACRG-QKIchr6163235313chr6163899812515DRB1-1469AWKFNFVGRILGPRG1025
PACRG-QKIchr6163235313chr6163899812515DRB1-1469IAWKFNFVGRILGPR924
PACRG-QKIchr6163235313chr6163899812515DRB1-1477AWKFNFVGRILGPRG1025
PACRG-QKIchr6163235313chr6163899812515DRB1-1477IAWKFNFVGRILGPR924
PACRG-QKIchr6163235313chr6163899812515DRB1-1477WKFNFVGRILGPRGL1126
PACRG-QKIchr6163235313chr6163899812515DRB1-1485AWKFNFVGRILGPRG1025
PACRG-QKIchr6163235313chr6163899812515DRB1-1489AWKFNFVGRILGPRG1025
PACRG-QKIchr6163235313chr6163899812515DRB1-1494AWKFNFVGRILGPRG1025
PACRG-QKIchr6163235313chr6163899812515DRB1-1498AWKFNFVGRILGPRG1025
PACRG-QKIchr6163235313chr6163899812515DRB3-0216KIAWKFNFVGRILGP823
PACRG-QKIchr6163235313chr6163983014515DRB1-0806GNKIAWKAEGEDSLK621
PACRG-QKIchr6163235313chr6163983014515DRB1-0806KGNKIAWKAEGEDSL520
PACRG-QKIchr6163235313chr6163983014515DRB1-0810GNKIAWKAEGEDSLK621

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Fusion breakpoint peptide structures of PACRG-QKI

check button3D structures of the fusion breakpoint peptide of 14AA sequence that have potential fusion neoantigens
* The minimum length of the amino acid sequence in RoseTTAFold is 14AA. Here, we predicted the 14AA fusion protein breakpoint sequence not the fusion neoantigen peptide, which is shorter than 14 AA.
File nameBPseqHgeneTgeneHchrHbpTchrTbpAAlen
2999GNKIAWKAEGEDSLPACRGQKIchr6163235313chr6163983014515
File nameBPseqHgeneTgeneHchrHbpTchrTbpAAlen
3000GNKIAWKFNFVGRIPACRGQKIchr6163235313chr6163899812515

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Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D of PACRG-QKI

check buttonVirtual screening between 25 HLAs (from PDB) and FusionNeoAntigens
* We used Glide to predict the interaction between HLAs and neoantigens.
HLA allelePDB IDFile nameBPseqDocking scoreGlide score
HLA-B14:023BVN2999GNKIAWKAEGEDSL-7.15543-7.26883
HLA-B14:023BVN2999GNKIAWKAEGEDSL-4.77435-5.80965
HLA-B52:013W392999GNKIAWKAEGEDSL-6.80875-6.92215
HLA-B52:013W392999GNKIAWKAEGEDSL-4.20386-5.23916
HLA-A11:014UQ22999GNKIAWKAEGEDSL-7.5194-8.5547
HLA-A11:014UQ22999GNKIAWKAEGEDSL-6.9601-7.0735
HLA-A24:025HGA2999GNKIAWKAEGEDSL-7.52403-7.63743
HLA-A24:025HGA2999GNKIAWKAEGEDSL-5.82433-6.85963
HLA-B27:056PYJ2999GNKIAWKAEGEDSL-3.28285-4.31815
HLA-B44:053DX82999GNKIAWKAEGEDSL-5.91172-6.94702
HLA-B44:053DX82999GNKIAWKAEGEDSL-4.24346-4.35686
HLA-B14:023BVN3000GNKIAWKFNFVGRI-7.15543-7.26883
HLA-B14:023BVN3000GNKIAWKFNFVGRI-4.77435-5.80965
HLA-B52:013W393000GNKIAWKFNFVGRI-6.80875-6.92215
HLA-B52:013W393000GNKIAWKFNFVGRI-4.20386-5.23916
HLA-A11:014UQ23000GNKIAWKFNFVGRI-7.5194-8.5547
HLA-A11:014UQ23000GNKIAWKFNFVGRI-6.9601-7.0735
HLA-A24:025HGA3000GNKIAWKFNFVGRI-7.52403-7.63743
HLA-A24:025HGA3000GNKIAWKFNFVGRI-5.82433-6.85963
HLA-B27:056PYJ3000GNKIAWKFNFVGRI-3.28285-4.31815
HLA-B44:053DX83000GNKIAWKFNFVGRI-5.91172-6.94702
HLA-B44:053DX83000GNKIAWKFNFVGRI-4.24346-4.35686

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Vaccine Design for the FusionNeoAntigens of PACRG-QKI

check button mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-Is.
Fusion geneHchrHbpTchrTbpStart in +/-13AAEnd in +/-13AAFusionNeoAntigen peptide sequenceFusionNeoAntigen RNA sequence
PACRG-QKIchr6163235313chr61638998121019AWKFNFVGRGCCTGGAAGTTTAATTTTGTTGGGAGA
PACRG-QKIchr6163235313chr61638998121221KFNFVGRILAAGTTTAATTTTGTTGGGAGAATCCTT
PACRG-QKIchr6163235313chr6163899812514KGNKIAWKFAAAGGAAACAAAATCGCCTGGAAGTTT
PACRG-QKIchr6163235313chr6163899812819KIAWKFNFVGRAAAATCGCCTGGAAGTTTAATTTTGTTGGGAGA
PACRG-QKIchr6163235313chr61639830141120WKAEGEDSLTGGAAGGCAGAAGGAGAAGACAGCCTG

check button mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-IIs.
Fusion geneHchrHbpTchrTbpStart in +/-13AAEnd in +/-13AAFusionNeoAntigen peptideFusionNEoAntigen RNA sequence
PACRG-QKIchr6163235313chr61638998121025AWKFNFVGRILGPRGGCCTGGAAGTTTAATTTTGTTGGGAGAATCCTTGGACCTAGAGGA
PACRG-QKIchr6163235313chr61638998121126WKFNFVGRILGPRGLTGGAAGTTTAATTTTGTTGGGAGAATCCTTGGACCTAGAGGACTT
PACRG-QKIchr6163235313chr6163899812823KIAWKFNFVGRILGPAAAATCGCCTGGAAGTTTAATTTTGTTGGGAGAATCCTTGGACCT
PACRG-QKIchr6163235313chr6163899812924IAWKFNFVGRILGPRATCGCCTGGAAGTTTAATTTTGTTGGGAGAATCCTTGGACCTAGA
PACRG-QKIchr6163235313chr6163983014520KGNKIAWKAEGEDSLAAAGGAAACAAAATCGCCTGGAAGGCAGAAGGAGAAGACAGCCTG
PACRG-QKIchr6163235313chr6163983014621GNKIAWKAEGEDSLKGGAAACAAAATCGCCTGGAAGGCAGAAGGAGAAGACAGCCTGAAG

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Information of the samples that have these potential fusion neoantigens of PACRG-QKI

check button These samples were reported as having these fusion breakpoints. For individual breakpoints, we checked the open reading frames considering multiple gene isoforms and chose the in-frame fusion genes only. Then, we made fusion protein sequences and predicted the fusion neoantigens. These fusion-positive samples may have these potential fusion neoantigens.
Cancer typeFusion geneHchrHbpHenstTchrTbpTenstSample
LGGPACRG-QKIchr6163235313ENST00000337019chr6163983014ENST00000275262TCGA-DU-6404-01A
LGGPACRG-QKIchr6163235313ENST00000337019chr6163899812ENST00000275262TCGA-HT-8114-01A

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Potential target of CAR-T therapy development for PACRG-QKI

check button Predicted 3D structure. We used RoseTTAFold.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, to provide the retention of the transmembrane domain, we only show the protein feature retention information of those transmembrane features


* Minus value of BPloci means that the break point is located before the CDS.
- In-frame and retained 'Transmembrane'.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

check button Subcellular localization prediction of the transmembrane domain retained fusion proteins
* We used DeepLoc 1.0. The order of the X-axis of the barplot is as follows: Entry_ID, Localization, Type, Nucleus, Cytoplasm, Extracellular, Mitochondrion, Cell_membrane, Endoplasmic_reticulum, Plastid, Golgi.apparatus, Lysosome.Vacuole, Peroxisome. Y-axis is the output score of DeepLoc. Clicking the image will open a new tab with a large image.
HgeneHchrHbpHenstTgeneTchrTbpTenstDeepLoc result

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Related Drugs to PACRG-QKI

check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to PACRG-QKI

check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneQKIC0036341Schizophrenia5PSYGENET
TgeneQKIC0017638Glioma1CTD_human
TgeneQKIC0041696Unipolar Depression1PSYGENET
TgeneQKIC0259783mixed gliomas1CTD_human
TgeneQKIC0555198Malignant Glioma1CTD_human
TgeneQKIC1269683Major Depressive Disorder1PSYGENET
TgeneQKIC2363903Angiocentric glioma1ORPHANET
TgeneQKIC3714756Intellectual Disability1GENOMICS_ENGLAND