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Center for Computational Systems Medicine
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Fusion Gene and Fusion Protein Summary

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Fusion Amino Acid Sequences (multiple BPs and multiple gene isoforms)

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Fusion Protein Breakpoint Sequences - (for the Screening of the FusionNeoAntigens)

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Potential FusionNeoAntigens in HLA I - (netMHCpan v4.1 + deepHLApan v1.1)

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Potential FusionNeoAntigens in HLA II - (netMHCIIpan v4.1)

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Fusion Breakpoint 14 AA Peptide Structure - (RoseTTAFold)

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Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D - (Glide)

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Vaccine Design for the FusionNeoAntigens (RNA/protein sequences)

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Potential target of CAR-T therapy development

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Information on the samples that have these potential fusion neoantigens

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Fusion Protein Targeting Drugs - (Manual Curation)

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Fusion Protein Related diseases - (Manual Curation)

Fusion Protein:PLEKHA5-AEBP2

Fusion Gene and Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: PLEKHA5-AEBP2
FusionPDB ID: 66174
FusionGDB2.0 ID: 66174
HgeneTgene
Gene symbol

PLEKHA5

AEBP2

Gene ID

54477

121536

Gene namepleckstrin homology domain containing A5AE binding protein 2
SynonymsPEPP-2|PEPP2-
Cytomap

12p12.3

12p12.3

Type of geneprotein-codingprotein-coding
Descriptionpleckstrin homology domain-containing family A member 5PH domain-containing family A member 5phosphoinositol 3-phosphate-binding protein-2pleckstrin homology domain containing, family A member 5zinc finger protein AEBP2AE(adipocyte enhancer)-binding protein 2adipocyte enhancer-binding protein 2
Modification date2020032020200313
UniProtAcc.

Q6ZN18

Main function of 5'-partner protein: FUNCTION: Acts as an accessory subunit for the core Polycomb repressive complex 2 (PRC2), which mediates histone H3K27 (H3K27me3) trimethylation on chromatin leading to transcriptional repression of the affected target gene (PubMed:15225548, PubMed:31959557, PubMed:29499137). Plays a role in nucleosome localization of the PRC2 complex (PubMed:29499137). {ECO:0000269|PubMed:15225548, ECO:0000269|PubMed:29499137, ECO:0000269|PubMed:31959557}.
Ensembl transtripts involved in fusion geneENST idsENST00000510738, ENST00000299275, 
ENST00000317589, ENST00000355397, 
ENST00000359180, ENST00000424268, 
ENST00000429027, ENST00000538714, 
ENST00000539256, ENST00000543806, 
ENST00000309364, ENST00000540972, 
ENST00000266508, ENST00000360995, 
ENST00000398864, ENST00000541908, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score19 X 17 X 12=387611 X 13 X 6=858
# samples 2315
** MAII scorelog2(23/3876*10)=-4.07486280447071
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(15/858*10)=-2.51601514700366
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Fusion gene context

PubMed: PLEKHA5 [Title/Abstract] AND AEBP2 [Title/Abstract] AND fusion [Title/Abstract]

Fusion neoantigen context

PubMed: PLEKHA5 [Title/Abstract] AND AEBP2 [Title/Abstract] AND neoantigen [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)AEBP2(19626289)-PLEKHA5(19410367), # samples:2
AEBP2(19615651)-PLEKHA5(19473496), # samples:2
PLEKHA5(19450296)-AEBP2(19537864), # samples:2
Anticipated loss of major functional domain due to fusion event.AEBP2-PLEKHA5 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
AEBP2-PLEKHA5 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
PLEKHA5-AEBP2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
PLEKHA5-AEBP2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
PLEKHA5-AEBP2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
PLEKHA5-AEBP2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:19626289/chr12:19410367)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonRetention analysis results of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features, are available here.

check buttonFusion gene breakpoints across PLEKHA5 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across AEBP2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


Top

Fusion Amino Acid Sequences


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000309364PLEKHA5chr1219440490+ENST00000541908AEBP2chr1219646733+25311931862455789
ENST00000309364PLEKHA5chr1219440490+ENST00000398864AEBP2chr1219646733+31531931862497803
ENST00000309364PLEKHA5chr1219440490+ENST00000266508AEBP2chr1219646733+45631931862455789
ENST00000309364PLEKHA5chr1219440490+ENST00000360995AEBP2chr1219646733+40011931862497803
ENST00000359180PLEKHA5chr1219440490+ENST00000541908AEBP2chr1219646733+25311931862455789
ENST00000359180PLEKHA5chr1219440490+ENST00000398864AEBP2chr1219646733+31531931862497803
ENST00000359180PLEKHA5chr1219440490+ENST00000266508AEBP2chr1219646733+45631931862455789
ENST00000359180PLEKHA5chr1219440490+ENST00000360995AEBP2chr1219646733+40011931862497803
ENST00000317589PLEKHA5chr1219440490+ENST00000541908AEBP2chr1219646733+25311931862455789
ENST00000317589PLEKHA5chr1219440490+ENST00000398864AEBP2chr1219646733+31531931862497803
ENST00000317589PLEKHA5chr1219440490+ENST00000266508AEBP2chr1219646733+45631931862455789
ENST00000317589PLEKHA5chr1219440490+ENST00000360995AEBP2chr1219646733+40011931862497803
ENST00000355397PLEKHA5chr1219440490+ENST00000541908AEBP2chr1219646733+25311931862455789
ENST00000355397PLEKHA5chr1219440490+ENST00000398864AEBP2chr1219646733+31531931862497803
ENST00000355397PLEKHA5chr1219440490+ENST00000266508AEBP2chr1219646733+45631931862455789
ENST00000355397PLEKHA5chr1219440490+ENST00000360995AEBP2chr1219646733+40011931862497803
ENST00000429027PLEKHA5chr1219440490+ENST00000541908AEBP2chr1219646733+24951895322419795
ENST00000429027PLEKHA5chr1219440490+ENST00000398864AEBP2chr1219646733+31171895322461809
ENST00000429027PLEKHA5chr1219440490+ENST00000266508AEBP2chr1219646733+45271895322419795
ENST00000429027PLEKHA5chr1219440490+ENST00000360995AEBP2chr1219646733+39651895322461809
ENST00000539256PLEKHA5chr1219440490+ENST00000541908AEBP2chr1219646733+237817785632302579
ENST00000539256PLEKHA5chr1219440490+ENST00000398864AEBP2chr1219646733+300017785632344593
ENST00000539256PLEKHA5chr1219440490+ENST00000266508AEBP2chr1219646733+441017785632302579
ENST00000539256PLEKHA5chr1219440490+ENST00000360995AEBP2chr1219646733+384817785632344593
ENST00000299275PLEKHA5chr1219440490+ENST00000541908AEBP2chr1219646733+2451185162375789
ENST00000299275PLEKHA5chr1219440490+ENST00000398864AEBP2chr1219646733+3073185162417803
ENST00000299275PLEKHA5chr1219440490+ENST00000266508AEBP2chr1219646733+4483185162375789
ENST00000299275PLEKHA5chr1219440490+ENST00000360995AEBP2chr1219646733+3921185162417803
ENST00000538714PLEKHA5chr1219440490+ENST00000541908AEBP2chr1219646733+2449184942373789
ENST00000538714PLEKHA5chr1219440490+ENST00000398864AEBP2chr1219646733+3071184942415803
ENST00000538714PLEKHA5chr1219440490+ENST00000266508AEBP2chr1219646733+4481184942373789
ENST00000538714PLEKHA5chr1219440490+ENST00000360995AEBP2chr1219646733+3919184942415803
ENST00000543806PLEKHA5chr1219440490+ENST00000541908AEBP2chr1219646733+233717372162261681
ENST00000543806PLEKHA5chr1219440490+ENST00000398864AEBP2chr1219646733+295917372162303695
ENST00000543806PLEKHA5chr1219440490+ENST00000266508AEBP2chr1219646733+436917372162261681
ENST00000543806PLEKHA5chr1219440490+ENST00000360995AEBP2chr1219646733+380717372162303695
ENST00000424268PLEKHA5chr1219440490+ENST00000541908AEBP2chr1219646733+233717372162261681
ENST00000424268PLEKHA5chr1219440490+ENST00000398864AEBP2chr1219646733+295917372162303695
ENST00000424268PLEKHA5chr1219440490+ENST00000266508AEBP2chr1219646733+436917372162261681
ENST00000424268PLEKHA5chr1219440490+ENST00000360995AEBP2chr1219646733+380717372162303695
ENST00000309364PLEKHA5chr1219436679+ENST00000541908AEBP2chr1219646733+24471847862371761
ENST00000309364PLEKHA5chr1219436679+ENST00000398864AEBP2chr1219646733+30691847862413775
ENST00000309364PLEKHA5chr1219436679+ENST00000266508AEBP2chr1219646733+44791847862371761
ENST00000309364PLEKHA5chr1219436679+ENST00000360995AEBP2chr1219646733+39171847862413775
ENST00000359180PLEKHA5chr1219436679+ENST00000541908AEBP2chr1219646733+24471847862371761
ENST00000359180PLEKHA5chr1219436679+ENST00000398864AEBP2chr1219646733+30691847862413775
ENST00000359180PLEKHA5chr1219436679+ENST00000266508AEBP2chr1219646733+44791847862371761
ENST00000359180PLEKHA5chr1219436679+ENST00000360995AEBP2chr1219646733+39171847862413775
ENST00000317589PLEKHA5chr1219436679+ENST00000541908AEBP2chr1219646733+24471847862371761
ENST00000317589PLEKHA5chr1219436679+ENST00000398864AEBP2chr1219646733+30691847862413775
ENST00000317589PLEKHA5chr1219436679+ENST00000266508AEBP2chr1219646733+44791847862371761
ENST00000317589PLEKHA5chr1219436679+ENST00000360995AEBP2chr1219646733+39171847862413775
ENST00000355397PLEKHA5chr1219436679+ENST00000541908AEBP2chr1219646733+24471847862371761
ENST00000355397PLEKHA5chr1219436679+ENST00000398864AEBP2chr1219646733+30691847862413775
ENST00000355397PLEKHA5chr1219436679+ENST00000266508AEBP2chr1219646733+44791847862371761
ENST00000355397PLEKHA5chr1219436679+ENST00000360995AEBP2chr1219646733+39171847862413775
ENST00000429027PLEKHA5chr1219436679+ENST00000541908AEBP2chr1219646733+24111811322335767
ENST00000429027PLEKHA5chr1219436679+ENST00000398864AEBP2chr1219646733+30331811322377781
ENST00000429027PLEKHA5chr1219436679+ENST00000266508AEBP2chr1219646733+44431811322335767
ENST00000429027PLEKHA5chr1219436679+ENST00000360995AEBP2chr1219646733+38811811322377781
ENST00000539256PLEKHA5chr1219436679+ENST00000541908AEBP2chr1219646733+229416945632218551
ENST00000539256PLEKHA5chr1219436679+ENST00000398864AEBP2chr1219646733+291616945632260565
ENST00000539256PLEKHA5chr1219436679+ENST00000266508AEBP2chr1219646733+432616945632218551
ENST00000539256PLEKHA5chr1219436679+ENST00000360995AEBP2chr1219646733+376416945632260565
ENST00000299275PLEKHA5chr1219436679+ENST00000541908AEBP2chr1219646733+2367176762291761
ENST00000299275PLEKHA5chr1219436679+ENST00000398864AEBP2chr1219646733+2989176762333775
ENST00000299275PLEKHA5chr1219436679+ENST00000266508AEBP2chr1219646733+4399176762291761
ENST00000299275PLEKHA5chr1219436679+ENST00000360995AEBP2chr1219646733+3837176762333775
ENST00000538714PLEKHA5chr1219436679+ENST00000541908AEBP2chr1219646733+2365176542289761
ENST00000538714PLEKHA5chr1219436679+ENST00000398864AEBP2chr1219646733+2987176542331775
ENST00000538714PLEKHA5chr1219436679+ENST00000266508AEBP2chr1219646733+4397176542289761
ENST00000538714PLEKHA5chr1219436679+ENST00000360995AEBP2chr1219646733+3835176542331775
ENST00000543806PLEKHA5chr1219436679+ENST00000541908AEBP2chr1219646733+225316532162177653
ENST00000543806PLEKHA5chr1219436679+ENST00000398864AEBP2chr1219646733+287516532162219667
ENST00000543806PLEKHA5chr1219436679+ENST00000266508AEBP2chr1219646733+428516532162177653
ENST00000543806PLEKHA5chr1219436679+ENST00000360995AEBP2chr1219646733+372316532162219667
ENST00000424268PLEKHA5chr1219436679+ENST00000541908AEBP2chr1219646733+225316532162177653
ENST00000424268PLEKHA5chr1219436679+ENST00000398864AEBP2chr1219646733+287516532162219667
ENST00000424268PLEKHA5chr1219436679+ENST00000266508AEBP2chr1219646733+428516532162177653
ENST00000424268PLEKHA5chr1219436679+ENST00000360995AEBP2chr1219646733+372316532162219667
ENST00000309364PLEKHA5chr1219440490+ENST00000541908AEBP2chr1219646734+25311931862455789
ENST00000309364PLEKHA5chr1219440490+ENST00000398864AEBP2chr1219646734+31531931862497803
ENST00000309364PLEKHA5chr1219440490+ENST00000266508AEBP2chr1219646734+45631931862455789
ENST00000309364PLEKHA5chr1219440490+ENST00000360995AEBP2chr1219646734+40011931862497803
ENST00000359180PLEKHA5chr1219440490+ENST00000541908AEBP2chr1219646734+25311931862455789
ENST00000359180PLEKHA5chr1219440490+ENST00000398864AEBP2chr1219646734+31531931862497803
ENST00000359180PLEKHA5chr1219440490+ENST00000266508AEBP2chr1219646734+45631931862455789
ENST00000359180PLEKHA5chr1219440490+ENST00000360995AEBP2chr1219646734+40011931862497803
ENST00000317589PLEKHA5chr1219440490+ENST00000541908AEBP2chr1219646734+25311931862455789
ENST00000317589PLEKHA5chr1219440490+ENST00000398864AEBP2chr1219646734+31531931862497803
ENST00000317589PLEKHA5chr1219440490+ENST00000266508AEBP2chr1219646734+45631931862455789
ENST00000317589PLEKHA5chr1219440490+ENST00000360995AEBP2chr1219646734+40011931862497803
ENST00000355397PLEKHA5chr1219440490+ENST00000541908AEBP2chr1219646734+25311931862455789
ENST00000355397PLEKHA5chr1219440490+ENST00000398864AEBP2chr1219646734+31531931862497803
ENST00000355397PLEKHA5chr1219440490+ENST00000266508AEBP2chr1219646734+45631931862455789
ENST00000355397PLEKHA5chr1219440490+ENST00000360995AEBP2chr1219646734+40011931862497803
ENST00000429027PLEKHA5chr1219440490+ENST00000541908AEBP2chr1219646734+24951895322419795
ENST00000429027PLEKHA5chr1219440490+ENST00000398864AEBP2chr1219646734+31171895322461809
ENST00000429027PLEKHA5chr1219440490+ENST00000266508AEBP2chr1219646734+45271895322419795
ENST00000429027PLEKHA5chr1219440490+ENST00000360995AEBP2chr1219646734+39651895322461809
ENST00000539256PLEKHA5chr1219440490+ENST00000541908AEBP2chr1219646734+237817785632302579
ENST00000539256PLEKHA5chr1219440490+ENST00000398864AEBP2chr1219646734+300017785632344593
ENST00000539256PLEKHA5chr1219440490+ENST00000266508AEBP2chr1219646734+441017785632302579
ENST00000539256PLEKHA5chr1219440490+ENST00000360995AEBP2chr1219646734+384817785632344593
ENST00000299275PLEKHA5chr1219440490+ENST00000541908AEBP2chr1219646734+2451185162375789
ENST00000299275PLEKHA5chr1219440490+ENST00000398864AEBP2chr1219646734+3073185162417803
ENST00000299275PLEKHA5chr1219440490+ENST00000266508AEBP2chr1219646734+4483185162375789
ENST00000299275PLEKHA5chr1219440490+ENST00000360995AEBP2chr1219646734+3921185162417803
ENST00000538714PLEKHA5chr1219440490+ENST00000541908AEBP2chr1219646734+2449184942373789
ENST00000538714PLEKHA5chr1219440490+ENST00000398864AEBP2chr1219646734+3071184942415803
ENST00000538714PLEKHA5chr1219440490+ENST00000266508AEBP2chr1219646734+4481184942373789
ENST00000538714PLEKHA5chr1219440490+ENST00000360995AEBP2chr1219646734+3919184942415803
ENST00000543806PLEKHA5chr1219440490+ENST00000541908AEBP2chr1219646734+233717372162261681
ENST00000543806PLEKHA5chr1219440490+ENST00000398864AEBP2chr1219646734+295917372162303695
ENST00000543806PLEKHA5chr1219440490+ENST00000266508AEBP2chr1219646734+436917372162261681
ENST00000543806PLEKHA5chr1219440490+ENST00000360995AEBP2chr1219646734+380717372162303695
ENST00000424268PLEKHA5chr1219440490+ENST00000541908AEBP2chr1219646734+233717372162261681
ENST00000424268PLEKHA5chr1219440490+ENST00000398864AEBP2chr1219646734+295917372162303695
ENST00000424268PLEKHA5chr1219440490+ENST00000266508AEBP2chr1219646734+436917372162261681
ENST00000424268PLEKHA5chr1219440490+ENST00000360995AEBP2chr1219646734+380717372162303695
ENST00000309364PLEKHA5chr1219436679+ENST00000541908AEBP2chr1219646734+24471847862371761
ENST00000309364PLEKHA5chr1219436679+ENST00000398864AEBP2chr1219646734+30691847862413775
ENST00000309364PLEKHA5chr1219436679+ENST00000266508AEBP2chr1219646734+44791847862371761
ENST00000309364PLEKHA5chr1219436679+ENST00000360995AEBP2chr1219646734+39171847862413775
ENST00000359180PLEKHA5chr1219436679+ENST00000541908AEBP2chr1219646734+24471847862371761
ENST00000359180PLEKHA5chr1219436679+ENST00000398864AEBP2chr1219646734+30691847862413775
ENST00000359180PLEKHA5chr1219436679+ENST00000266508AEBP2chr1219646734+44791847862371761
ENST00000359180PLEKHA5chr1219436679+ENST00000360995AEBP2chr1219646734+39171847862413775
ENST00000317589PLEKHA5chr1219436679+ENST00000541908AEBP2chr1219646734+24471847862371761
ENST00000317589PLEKHA5chr1219436679+ENST00000398864AEBP2chr1219646734+30691847862413775
ENST00000317589PLEKHA5chr1219436679+ENST00000266508AEBP2chr1219646734+44791847862371761
ENST00000317589PLEKHA5chr1219436679+ENST00000360995AEBP2chr1219646734+39171847862413775
ENST00000355397PLEKHA5chr1219436679+ENST00000541908AEBP2chr1219646734+24471847862371761
ENST00000355397PLEKHA5chr1219436679+ENST00000398864AEBP2chr1219646734+30691847862413775
ENST00000355397PLEKHA5chr1219436679+ENST00000266508AEBP2chr1219646734+44791847862371761
ENST00000355397PLEKHA5chr1219436679+ENST00000360995AEBP2chr1219646734+39171847862413775
ENST00000429027PLEKHA5chr1219436679+ENST00000541908AEBP2chr1219646734+24111811322335767
ENST00000429027PLEKHA5chr1219436679+ENST00000398864AEBP2chr1219646734+30331811322377781
ENST00000429027PLEKHA5chr1219436679+ENST00000266508AEBP2chr1219646734+44431811322335767
ENST00000429027PLEKHA5chr1219436679+ENST00000360995AEBP2chr1219646734+38811811322377781
ENST00000539256PLEKHA5chr1219436679+ENST00000541908AEBP2chr1219646734+229416945632218551
ENST00000539256PLEKHA5chr1219436679+ENST00000398864AEBP2chr1219646734+291616945632260565
ENST00000539256PLEKHA5chr1219436679+ENST00000266508AEBP2chr1219646734+432616945632218551
ENST00000539256PLEKHA5chr1219436679+ENST00000360995AEBP2chr1219646734+376416945632260565
ENST00000299275PLEKHA5chr1219436679+ENST00000541908AEBP2chr1219646734+2367176762291761
ENST00000299275PLEKHA5chr1219436679+ENST00000398864AEBP2chr1219646734+2989176762333775
ENST00000299275PLEKHA5chr1219436679+ENST00000266508AEBP2chr1219646734+4399176762291761
ENST00000299275PLEKHA5chr1219436679+ENST00000360995AEBP2chr1219646734+3837176762333775
ENST00000538714PLEKHA5chr1219436679+ENST00000541908AEBP2chr1219646734+2365176542289761
ENST00000538714PLEKHA5chr1219436679+ENST00000398864AEBP2chr1219646734+2987176542331775
ENST00000538714PLEKHA5chr1219436679+ENST00000266508AEBP2chr1219646734+4397176542289761
ENST00000538714PLEKHA5chr1219436679+ENST00000360995AEBP2chr1219646734+3835176542331775
ENST00000543806PLEKHA5chr1219436679+ENST00000541908AEBP2chr1219646734+225316532162177653
ENST00000543806PLEKHA5chr1219436679+ENST00000398864AEBP2chr1219646734+287516532162219667
ENST00000543806PLEKHA5chr1219436679+ENST00000266508AEBP2chr1219646734+428516532162177653
ENST00000543806PLEKHA5chr1219436679+ENST00000360995AEBP2chr1219646734+372316532162219667
ENST00000424268PLEKHA5chr1219436679+ENST00000541908AEBP2chr1219646734+225316532162177653
ENST00000424268PLEKHA5chr1219436679+ENST00000398864AEBP2chr1219646734+287516532162219667
ENST00000424268PLEKHA5chr1219436679+ENST00000266508AEBP2chr1219646734+428516532162177653
ENST00000424268PLEKHA5chr1219436679+ENST00000360995AEBP2chr1219646734+372316532162219667

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000309364ENST00000541908PLEKHA5chr1219440490+AEBP2chr1219646733+0.0016403070.9983596
ENST00000309364ENST00000398864PLEKHA5chr1219440490+AEBP2chr1219646733+0.0006950830.9993049
ENST00000309364ENST00000266508PLEKHA5chr1219440490+AEBP2chr1219646733+0.000237020.99976295
ENST00000309364ENST00000360995PLEKHA5chr1219440490+AEBP2chr1219646733+0.0002867370.99971324
ENST00000359180ENST00000541908PLEKHA5chr1219440490+AEBP2chr1219646733+0.0016403070.9983596
ENST00000359180ENST00000398864PLEKHA5chr1219440490+AEBP2chr1219646733+0.0006950830.9993049
ENST00000359180ENST00000266508PLEKHA5chr1219440490+AEBP2chr1219646733+0.000237020.99976295
ENST00000359180ENST00000360995PLEKHA5chr1219440490+AEBP2chr1219646733+0.0002867370.99971324
ENST00000317589ENST00000541908PLEKHA5chr1219440490+AEBP2chr1219646733+0.0016403070.9983596
ENST00000317589ENST00000398864PLEKHA5chr1219440490+AEBP2chr1219646733+0.0006950830.9993049
ENST00000317589ENST00000266508PLEKHA5chr1219440490+AEBP2chr1219646733+0.000237020.99976295
ENST00000317589ENST00000360995PLEKHA5chr1219440490+AEBP2chr1219646733+0.0002867370.99971324
ENST00000355397ENST00000541908PLEKHA5chr1219440490+AEBP2chr1219646733+0.0016403070.9983596
ENST00000355397ENST00000398864PLEKHA5chr1219440490+AEBP2chr1219646733+0.0006950830.9993049
ENST00000355397ENST00000266508PLEKHA5chr1219440490+AEBP2chr1219646733+0.000237020.99976295
ENST00000355397ENST00000360995PLEKHA5chr1219440490+AEBP2chr1219646733+0.0002867370.99971324
ENST00000429027ENST00000541908PLEKHA5chr1219440490+AEBP2chr1219646733+0.0014567050.99854326
ENST00000429027ENST00000398864PLEKHA5chr1219440490+AEBP2chr1219646733+0.0005760460.999424
ENST00000429027ENST00000266508PLEKHA5chr1219440490+AEBP2chr1219646733+0.0002234690.99977654
ENST00000429027ENST00000360995PLEKHA5chr1219440490+AEBP2chr1219646733+0.0002534010.9997466
ENST00000539256ENST00000541908PLEKHA5chr1219440490+AEBP2chr1219646733+0.0031996470.9968003
ENST00000539256ENST00000398864PLEKHA5chr1219440490+AEBP2chr1219646733+0.0011301540.99886984
ENST00000539256ENST00000266508PLEKHA5chr1219440490+AEBP2chr1219646733+0.0003769190.99962306
ENST00000539256ENST00000360995PLEKHA5chr1219440490+AEBP2chr1219646733+0.0004513040.9995486
ENST00000299275ENST00000541908PLEKHA5chr1219440490+AEBP2chr1219646733+0.0014576250.9985424
ENST00000299275ENST00000398864PLEKHA5chr1219440490+AEBP2chr1219646733+0.0005785270.9994215
ENST00000299275ENST00000266508PLEKHA5chr1219440490+AEBP2chr1219646733+0.0002259150.99977404
ENST00000299275ENST00000360995PLEKHA5chr1219440490+AEBP2chr1219646733+0.0002560410.999744
ENST00000538714ENST00000541908PLEKHA5chr1219440490+AEBP2chr1219646733+0.0014390160.99856097
ENST00000538714ENST00000398864PLEKHA5chr1219440490+AEBP2chr1219646733+0.0005698590.9994301
ENST00000538714ENST00000266508PLEKHA5chr1219440490+AEBP2chr1219646733+0.0002249630.999775
ENST00000538714ENST00000360995PLEKHA5chr1219440490+AEBP2chr1219646733+0.0002538670.99974614
ENST00000543806ENST00000541908PLEKHA5chr1219440490+AEBP2chr1219646733+0.0028048470.9971951
ENST00000543806ENST00000398864PLEKHA5chr1219440490+AEBP2chr1219646733+0.0011346430.99886537
ENST00000543806ENST00000266508PLEKHA5chr1219440490+AEBP2chr1219646733+0.0004767960.99952316
ENST00000543806ENST00000360995PLEKHA5chr1219440490+AEBP2chr1219646733+0.000572510.99942756
ENST00000424268ENST00000541908PLEKHA5chr1219440490+AEBP2chr1219646733+0.0028048470.9971951
ENST00000424268ENST00000398864PLEKHA5chr1219440490+AEBP2chr1219646733+0.0011346430.99886537
ENST00000424268ENST00000266508PLEKHA5chr1219440490+AEBP2chr1219646733+0.0004767960.99952316
ENST00000424268ENST00000360995PLEKHA5chr1219440490+AEBP2chr1219646733+0.000572510.99942756
ENST00000309364ENST00000541908PLEKHA5chr1219436679+AEBP2chr1219646733+0.0021571420.9978428
ENST00000309364ENST00000398864PLEKHA5chr1219436679+AEBP2chr1219646733+0.000825820.9991742
ENST00000309364ENST00000266508PLEKHA5chr1219436679+AEBP2chr1219646733+0.0002800440.9997199
ENST00000309364ENST00000360995PLEKHA5chr1219436679+AEBP2chr1219646733+0.0003289720.999671
ENST00000359180ENST00000541908PLEKHA5chr1219436679+AEBP2chr1219646733+0.0021571420.9978428
ENST00000359180ENST00000398864PLEKHA5chr1219436679+AEBP2chr1219646733+0.000825820.9991742
ENST00000359180ENST00000266508PLEKHA5chr1219436679+AEBP2chr1219646733+0.0002800440.9997199
ENST00000359180ENST00000360995PLEKHA5chr1219436679+AEBP2chr1219646733+0.0003289720.999671
ENST00000317589ENST00000541908PLEKHA5chr1219436679+AEBP2chr1219646733+0.0021571420.9978428
ENST00000317589ENST00000398864PLEKHA5chr1219436679+AEBP2chr1219646733+0.000825820.9991742
ENST00000317589ENST00000266508PLEKHA5chr1219436679+AEBP2chr1219646733+0.0002800440.9997199
ENST00000317589ENST00000360995PLEKHA5chr1219436679+AEBP2chr1219646733+0.0003289720.999671
ENST00000355397ENST00000541908PLEKHA5chr1219436679+AEBP2chr1219646733+0.0021571420.9978428
ENST00000355397ENST00000398864PLEKHA5chr1219436679+AEBP2chr1219646733+0.000825820.9991742
ENST00000355397ENST00000266508PLEKHA5chr1219436679+AEBP2chr1219646733+0.0002800440.9997199
ENST00000355397ENST00000360995PLEKHA5chr1219436679+AEBP2chr1219646733+0.0003289720.999671
ENST00000429027ENST00000541908PLEKHA5chr1219436679+AEBP2chr1219646733+0.0019682010.9980318
ENST00000429027ENST00000398864PLEKHA5chr1219436679+AEBP2chr1219646733+0.000697510.9993025
ENST00000429027ENST00000266508PLEKHA5chr1219436679+AEBP2chr1219646733+0.0002616270.9997384
ENST00000429027ENST00000360995PLEKHA5chr1219436679+AEBP2chr1219646733+0.0002864980.9997135
ENST00000539256ENST00000541908PLEKHA5chr1219436679+AEBP2chr1219646733+0.0043326540.99566734
ENST00000539256ENST00000398864PLEKHA5chr1219436679+AEBP2chr1219646733+0.0014318930.99856806
ENST00000539256ENST00000266508PLEKHA5chr1219436679+AEBP2chr1219646733+0.0004436370.99955636
ENST00000539256ENST00000360995PLEKHA5chr1219436679+AEBP2chr1219646733+0.0005631360.9994368
ENST00000299275ENST00000541908PLEKHA5chr1219436679+AEBP2chr1219646733+0.0019693980.9980306
ENST00000299275ENST00000398864PLEKHA5chr1219436679+AEBP2chr1219646733+0.0006840450.999316
ENST00000299275ENST00000266508PLEKHA5chr1219436679+AEBP2chr1219646733+0.0002637360.99973625
ENST00000299275ENST00000360995PLEKHA5chr1219436679+AEBP2chr1219646733+0.0002848220.99971515
ENST00000538714ENST00000541908PLEKHA5chr1219436679+AEBP2chr1219646733+0.0019462890.9980538
ENST00000538714ENST00000398864PLEKHA5chr1219436679+AEBP2chr1219646733+0.000672260.9993278
ENST00000538714ENST00000266508PLEKHA5chr1219436679+AEBP2chr1219646733+0.0002628340.9997372
ENST00000538714ENST00000360995PLEKHA5chr1219436679+AEBP2chr1219646733+0.0002819790.999718
ENST00000543806ENST00000541908PLEKHA5chr1219436679+AEBP2chr1219646733+0.0035001640.9964998
ENST00000543806ENST00000398864PLEKHA5chr1219436679+AEBP2chr1219646733+0.0012639090.9987361
ENST00000543806ENST00000266508PLEKHA5chr1219436679+AEBP2chr1219646733+0.0005175710.9994824
ENST00000543806ENST00000360995PLEKHA5chr1219436679+AEBP2chr1219646733+0.0006073710.9993926
ENST00000424268ENST00000541908PLEKHA5chr1219436679+AEBP2chr1219646733+0.0035001640.9964998
ENST00000424268ENST00000398864PLEKHA5chr1219436679+AEBP2chr1219646733+0.0012639090.9987361
ENST00000424268ENST00000266508PLEKHA5chr1219436679+AEBP2chr1219646733+0.0005175710.9994824
ENST00000424268ENST00000360995PLEKHA5chr1219436679+AEBP2chr1219646733+0.0006073710.9993926
ENST00000309364ENST00000541908PLEKHA5chr1219440490+AEBP2chr1219646734+0.0016403070.9983596
ENST00000309364ENST00000398864PLEKHA5chr1219440490+AEBP2chr1219646734+0.0006950830.9993049
ENST00000309364ENST00000266508PLEKHA5chr1219440490+AEBP2chr1219646734+0.000237020.99976295
ENST00000309364ENST00000360995PLEKHA5chr1219440490+AEBP2chr1219646734+0.0002867370.99971324
ENST00000359180ENST00000541908PLEKHA5chr1219440490+AEBP2chr1219646734+0.0016403070.9983596
ENST00000359180ENST00000398864PLEKHA5chr1219440490+AEBP2chr1219646734+0.0006950830.9993049
ENST00000359180ENST00000266508PLEKHA5chr1219440490+AEBP2chr1219646734+0.000237020.99976295
ENST00000359180ENST00000360995PLEKHA5chr1219440490+AEBP2chr1219646734+0.0002867370.99971324
ENST00000317589ENST00000541908PLEKHA5chr1219440490+AEBP2chr1219646734+0.0016403070.9983596
ENST00000317589ENST00000398864PLEKHA5chr1219440490+AEBP2chr1219646734+0.0006950830.9993049
ENST00000317589ENST00000266508PLEKHA5chr1219440490+AEBP2chr1219646734+0.000237020.99976295
ENST00000317589ENST00000360995PLEKHA5chr1219440490+AEBP2chr1219646734+0.0002867370.99971324
ENST00000355397ENST00000541908PLEKHA5chr1219440490+AEBP2chr1219646734+0.0016403070.9983596
ENST00000355397ENST00000398864PLEKHA5chr1219440490+AEBP2chr1219646734+0.0006950830.9993049
ENST00000355397ENST00000266508PLEKHA5chr1219440490+AEBP2chr1219646734+0.000237020.99976295
ENST00000355397ENST00000360995PLEKHA5chr1219440490+AEBP2chr1219646734+0.0002867370.99971324
ENST00000429027ENST00000541908PLEKHA5chr1219440490+AEBP2chr1219646734+0.0014567050.99854326
ENST00000429027ENST00000398864PLEKHA5chr1219440490+AEBP2chr1219646734+0.0005760460.999424
ENST00000429027ENST00000266508PLEKHA5chr1219440490+AEBP2chr1219646734+0.0002234690.99977654
ENST00000429027ENST00000360995PLEKHA5chr1219440490+AEBP2chr1219646734+0.0002534010.9997466
ENST00000539256ENST00000541908PLEKHA5chr1219440490+AEBP2chr1219646734+0.0031996470.9968003
ENST00000539256ENST00000398864PLEKHA5chr1219440490+AEBP2chr1219646734+0.0011301540.99886984
ENST00000539256ENST00000266508PLEKHA5chr1219440490+AEBP2chr1219646734+0.0003769190.99962306
ENST00000539256ENST00000360995PLEKHA5chr1219440490+AEBP2chr1219646734+0.0004513040.9995486
ENST00000299275ENST00000541908PLEKHA5chr1219440490+AEBP2chr1219646734+0.0014576250.9985424
ENST00000299275ENST00000398864PLEKHA5chr1219440490+AEBP2chr1219646734+0.0005785270.9994215
ENST00000299275ENST00000266508PLEKHA5chr1219440490+AEBP2chr1219646734+0.0002259150.99977404
ENST00000299275ENST00000360995PLEKHA5chr1219440490+AEBP2chr1219646734+0.0002560410.999744
ENST00000538714ENST00000541908PLEKHA5chr1219440490+AEBP2chr1219646734+0.0014390160.99856097
ENST00000538714ENST00000398864PLEKHA5chr1219440490+AEBP2chr1219646734+0.0005698590.9994301
ENST00000538714ENST00000266508PLEKHA5chr1219440490+AEBP2chr1219646734+0.0002249630.999775
ENST00000538714ENST00000360995PLEKHA5chr1219440490+AEBP2chr1219646734+0.0002538670.99974614
ENST00000543806ENST00000541908PLEKHA5chr1219440490+AEBP2chr1219646734+0.0028048470.9971951
ENST00000543806ENST00000398864PLEKHA5chr1219440490+AEBP2chr1219646734+0.0011346430.99886537
ENST00000543806ENST00000266508PLEKHA5chr1219440490+AEBP2chr1219646734+0.0004767960.99952316
ENST00000543806ENST00000360995PLEKHA5chr1219440490+AEBP2chr1219646734+0.000572510.99942756
ENST00000424268ENST00000541908PLEKHA5chr1219440490+AEBP2chr1219646734+0.0028048470.9971951
ENST00000424268ENST00000398864PLEKHA5chr1219440490+AEBP2chr1219646734+0.0011346430.99886537
ENST00000424268ENST00000266508PLEKHA5chr1219440490+AEBP2chr1219646734+0.0004767960.99952316
ENST00000424268ENST00000360995PLEKHA5chr1219440490+AEBP2chr1219646734+0.000572510.99942756
ENST00000309364ENST00000541908PLEKHA5chr1219436679+AEBP2chr1219646734+0.0021571420.9978428
ENST00000309364ENST00000398864PLEKHA5chr1219436679+AEBP2chr1219646734+0.000825820.9991742
ENST00000309364ENST00000266508PLEKHA5chr1219436679+AEBP2chr1219646734+0.0002800440.9997199
ENST00000309364ENST00000360995PLEKHA5chr1219436679+AEBP2chr1219646734+0.0003289720.999671
ENST00000359180ENST00000541908PLEKHA5chr1219436679+AEBP2chr1219646734+0.0021571420.9978428
ENST00000359180ENST00000398864PLEKHA5chr1219436679+AEBP2chr1219646734+0.000825820.9991742
ENST00000359180ENST00000266508PLEKHA5chr1219436679+AEBP2chr1219646734+0.0002800440.9997199
ENST00000359180ENST00000360995PLEKHA5chr1219436679+AEBP2chr1219646734+0.0003289720.999671
ENST00000317589ENST00000541908PLEKHA5chr1219436679+AEBP2chr1219646734+0.0021571420.9978428
ENST00000317589ENST00000398864PLEKHA5chr1219436679+AEBP2chr1219646734+0.000825820.9991742
ENST00000317589ENST00000266508PLEKHA5chr1219436679+AEBP2chr1219646734+0.0002800440.9997199
ENST00000317589ENST00000360995PLEKHA5chr1219436679+AEBP2chr1219646734+0.0003289720.999671
ENST00000355397ENST00000541908PLEKHA5chr1219436679+AEBP2chr1219646734+0.0021571420.9978428
ENST00000355397ENST00000398864PLEKHA5chr1219436679+AEBP2chr1219646734+0.000825820.9991742
ENST00000355397ENST00000266508PLEKHA5chr1219436679+AEBP2chr1219646734+0.0002800440.9997199
ENST00000355397ENST00000360995PLEKHA5chr1219436679+AEBP2chr1219646734+0.0003289720.999671
ENST00000429027ENST00000541908PLEKHA5chr1219436679+AEBP2chr1219646734+0.0019682010.9980318
ENST00000429027ENST00000398864PLEKHA5chr1219436679+AEBP2chr1219646734+0.000697510.9993025
ENST00000429027ENST00000266508PLEKHA5chr1219436679+AEBP2chr1219646734+0.0002616270.9997384
ENST00000429027ENST00000360995PLEKHA5chr1219436679+AEBP2chr1219646734+0.0002864980.9997135
ENST00000539256ENST00000541908PLEKHA5chr1219436679+AEBP2chr1219646734+0.0043326540.99566734
ENST00000539256ENST00000398864PLEKHA5chr1219436679+AEBP2chr1219646734+0.0014318930.99856806
ENST00000539256ENST00000266508PLEKHA5chr1219436679+AEBP2chr1219646734+0.0004436370.99955636
ENST00000539256ENST00000360995PLEKHA5chr1219436679+AEBP2chr1219646734+0.0005631360.9994368
ENST00000299275ENST00000541908PLEKHA5chr1219436679+AEBP2chr1219646734+0.0019693980.9980306
ENST00000299275ENST00000398864PLEKHA5chr1219436679+AEBP2chr1219646734+0.0006840450.999316
ENST00000299275ENST00000266508PLEKHA5chr1219436679+AEBP2chr1219646734+0.0002637360.99973625
ENST00000299275ENST00000360995PLEKHA5chr1219436679+AEBP2chr1219646734+0.0002848220.99971515
ENST00000538714ENST00000541908PLEKHA5chr1219436679+AEBP2chr1219646734+0.0019462890.9980538
ENST00000538714ENST00000398864PLEKHA5chr1219436679+AEBP2chr1219646734+0.000672260.9993278
ENST00000538714ENST00000266508PLEKHA5chr1219436679+AEBP2chr1219646734+0.0002628340.9997372
ENST00000538714ENST00000360995PLEKHA5chr1219436679+AEBP2chr1219646734+0.0002819790.999718
ENST00000543806ENST00000541908PLEKHA5chr1219436679+AEBP2chr1219646734+0.0035001640.9964998
ENST00000543806ENST00000398864PLEKHA5chr1219436679+AEBP2chr1219646734+0.0012639090.9987361
ENST00000543806ENST00000266508PLEKHA5chr1219436679+AEBP2chr1219646734+0.0005175710.9994824
ENST00000543806ENST00000360995PLEKHA5chr1219436679+AEBP2chr1219646734+0.0006073710.9993926
ENST00000424268ENST00000541908PLEKHA5chr1219436679+AEBP2chr1219646734+0.0035001640.9964998
ENST00000424268ENST00000398864PLEKHA5chr1219436679+AEBP2chr1219646734+0.0012639090.9987361
ENST00000424268ENST00000266508PLEKHA5chr1219436679+AEBP2chr1219646734+0.0005175710.9994824
ENST00000424268ENST00000360995PLEKHA5chr1219436679+AEBP2chr1219646734+0.0006073710.9993926

check button Predicted full-length fusion amino acid sequences. For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among all the predicted ones.

Get the fusion protein sequences from here.

Fusion protein sequence information is available in the fasta format.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

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Fusion Protein Breakpoint Sequences for PLEKHA5-AEBP2

check button +/-13 AA sequence from the breakpoints of the fusion protein sequences.
HgeneHchrHbpTgeneTchrTbpLength(fusion protein)BP in fusion proteinPeptide

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Potential FusionNeoAntigen Information of PLEKHA5-AEBP2 in HLA I

check button Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.

check button Potential FusionNeoAntigen Information
* We used NetMHCpan v4.1 (%rank<0.5) and deepHLApan v1.1 (immunogenic score>0.5)
Fusion geneHchrHbpTgeneTchrTbpHLA IFusionNeoAntigen peptideBinding scoreImmunogenic scoreNeoantigen start (at BP 13)Neoantigen end (at BP 13)

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Potential FusionNeoAntigen Information of PLEKHA5-AEBP2 in HLA II

check button Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.

check button Potential FusionNeoAntigen Information
* We used NetMHCIIpan v4.1 (%rank<0.5).
Fusion geneHchrHbpTgeneTchrTbpHLA IIFusionNeoAntigen peptideNeoantigen start (at BP 13)Neoantigen end (at BP 13)

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Fusion breakpoint peptide structures of PLEKHA5-AEBP2

check button3D structures of the fusion breakpoint peptide of 14AA sequence that have potential fusion neoantigens
* The minimum length of the amino acid sequence in RoseTTAFold is 14AA. Here, we predicted the 14AA fusion protein breakpoint sequence not the fusion neoantigen peptide, which is shorter than 14 AA.

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Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D of PLEKHA5-AEBP2

check buttonVirtual screening between 25 HLAs (from PDB) and FusionNeoAntigens
* We used Glide to predict the interaction between HLAs and neoantigens.
HLA allelePDB IDFile nameBPseqDocking scoreGlide score

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Vaccine Design for the FusionNeoAntigens of PLEKHA5-AEBP2

check button mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-Is.
Fusion geneHchrHbpTchrTbpStart in +/-13AAEnd in +/-13AAFusionNeoAntigen peptide sequenceFusionNeoAntigen RNA sequence

check button mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-IIs.
Fusion geneHchrHbpTchrTbpStart in +/-13AAEnd in +/-13AAFusionNeoAntigen peptideFusionNEoAntigen RNA sequence

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Information of the samples that have these potential fusion neoantigens of PLEKHA5-AEBP2

check button These samples were reported as having these fusion breakpoints. For individual breakpoints, we checked the open reading frames considering multiple gene isoforms and chose the in-frame fusion genes only. Then, we made fusion protein sequences and predicted the fusion neoantigens. These fusion-positive samples may have these potential fusion neoantigens.
Cancer typeFusion geneHchrHbpHenstTchrTbpTenstSample

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Potential target of CAR-T therapy development for PLEKHA5-AEBP2

check button Predicted 3D structure. We used RoseTTAFold.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, to provide the retention of the transmembrane domain, we only show the protein feature retention information of those transmembrane features


* Minus value of BPloci means that the break point is located before the CDS.
- In-frame and retained 'Transmembrane'.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

check button Subcellular localization prediction of the transmembrane domain retained fusion proteins
* We used DeepLoc 1.0. The order of the X-axis of the barplot is as follows: Entry_ID, Localization, Type, Nucleus, Cytoplasm, Extracellular, Mitochondrion, Cell_membrane, Endoplasmic_reticulum, Plastid, Golgi.apparatus, Lysosome.Vacuole, Peroxisome. Y-axis is the output score of DeepLoc. Clicking the image will open a new tab with a large image.
HgeneHchrHbpHenstTgeneTchrTbpTenstDeepLoc result

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Related Drugs to PLEKHA5-AEBP2

check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to PLEKHA5-AEBP2

check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource