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Center for Computational Systems Medicine
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Fusion Gene and Fusion Protein Summary

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Fusion Amino Acid Sequences (multiple BPs and multiple gene isoforms)

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Fusion Protein Breakpoint Sequences - (for the Screening of the FusionNeoAntigens)

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Potential FusionNeoAntigens in HLA I - (netMHCpan v4.1 + deepHLApan v1.1)

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Potential FusionNeoAntigens in HLA II - (netMHCIIpan v4.1)

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Fusion Breakpoint 14 AA Peptide Structure - (RoseTTAFold)

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Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D - (Glide)

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Vaccine Design for the FusionNeoAntigens (RNA/protein sequences)

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Potential target of CAR-T therapy development

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Information on the samples that have these potential fusion neoantigens

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Fusion Protein Targeting Drugs - (Manual Curation)

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Fusion Protein Related diseases - (Manual Curation)

Fusion Protein:PPARA-FBLN1

Fusion Gene and Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: PPARA-FBLN1
FusionPDB ID: 67315
FusionGDB2.0 ID: 67315
HgeneTgene
Gene symbol

PPARA

FBLN1

Gene ID

5465

2192

Gene nameperoxisome proliferator activated receptor alphafibulin 1
SynonymsNR1C1|PPAR|PPARalpha|hPPARFBLN|FIBL1
Cytomap

22q13.31

22q13.31

Type of geneprotein-codingprotein-coding
Descriptionperoxisome proliferator-activated receptor alphaPPAR-alphanuclear receptor subfamily 1 group C member 1peroxisome proliferative activated receptor, alphaperoxisome proliferator-activated nuclear receptor alpha variant 3fibulin-1
Modification date2020032920200313
UniProtAcc.

P23142

Main function of 5'-partner protein: FUNCTION: Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes. Has been implicated in a role in cellular transformation and tumor invasion, it appears to be a tumor suppressor. May play a role in haemostasis and thrombosis owing to its ability to bind fibrinogen and incorporate into clots. Could play a significant role in modulating the neurotrophic activities of APP, particularly soluble APP. {ECO:0000269|PubMed:11792823, ECO:0000269|PubMed:9393974, ECO:0000269|PubMed:9466671}.
Ensembl transtripts involved in fusion geneENST idsENST00000262735, ENST00000396000, 
ENST00000402126, ENST00000407236, 
ENST00000434345, ENST00000481567, 
ENST00000476366, ENST00000262722, 
ENST00000327858, ENST00000340923, 
ENST00000348697, ENST00000402984, 
ENST00000442170, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score15 X 10 X 10=150022 X 22 X 9=4356
# samples 1827
** MAII scorelog2(18/1500*10)=-3.05889368905357
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(27/4356*10)=-4.01197264166608
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Fusion gene context

PubMed: PPARA [Title/Abstract] AND FBLN1 [Title/Abstract] AND fusion [Title/Abstract]

Fusion neoantigen context

PubMed: PPARA [Title/Abstract] AND FBLN1 [Title/Abstract] AND neoantigen [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)PPARA(46594488)-FBLN1(45942965), # samples:2
Anticipated loss of major functional domain due to fusion event.PPARA-FBLN1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
PPARA-FBLN1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
PPARA-FBLN1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
PPARA-FBLN1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePPARA

GO:0000122

negative regulation of transcription by RNA polymerase II

9748239|12700342

HgenePPARA

GO:0010565

regulation of cellular ketone metabolic process

19955185

HgenePPARA

GO:0010745

negative regulation of macrophage derived foam cell differentiation

19114110

HgenePPARA

GO:0010871

negative regulation of receptor biosynthetic process

12700342

HgenePPARA

GO:0010887

negative regulation of cholesterol storage

19114110

HgenePPARA

GO:0010891

negative regulation of sequestering of triglyceride

12700342

HgenePPARA

GO:0019217

regulation of fatty acid metabolic process

19955185

HgenePPARA

GO:0045820

negative regulation of glycolytic process

19955185

HgenePPARA

GO:0045893

positive regulation of transcription, DNA-templated

12955147

HgenePPARA

GO:0045944

positive regulation of transcription by RNA polymerase II

9748239|19955185|20837115

HgenePPARA

GO:0050728

negative regulation of inflammatory response

21636785

HgenePPARA

GO:1902894

negative regulation of pri-miRNA transcription by RNA polymerase II

21636785

HgenePPARA

GO:1903038

negative regulation of leukocyte cell-cell adhesion

21636785

TgeneFBLN1

GO:0001933

negative regulation of protein phosphorylation

11792823

TgeneFBLN1

GO:0007162

negative regulation of cell adhesion

11792823

TgeneFBLN1

GO:0007229

integrin-mediated signaling pathway

11792823

TgeneFBLN1

GO:0070373

negative regulation of ERK1 and ERK2 cascade

11792823

TgeneFBLN1

GO:0072378

blood coagulation, fibrin clot formation

7642629

TgeneFBLN1

GO:1900025

negative regulation of substrate adhesion-dependent cell spreading

11792823

TgeneFBLN1

GO:2000146

negative regulation of cell motility

11792823

TgeneFBLN1

GO:2000647

negative regulation of stem cell proliferation

11238726



check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr22:46594488/chr22:45942965)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonRetention analysis results of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features, are available here.

check buttonFusion gene breakpoints across PPARA (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across FBLN1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Amino Acid Sequences


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000396000PPARAchr2246594488+ENST00000348697FBLN1chr2245942965+19524732561263335
ENST00000396000PPARAchr2246594488+ENST00000402984FBLN1chr2245942965+12904732561203315
ENST00000396000PPARAchr2246594488+ENST00000262722FBLN1chr2245942965+13004732561203315
ENST00000396000PPARAchr2246594488+ENST00000327858FBLN1chr2245942965+19534732561263335
ENST00000396000PPARAchr2246594488+ENST00000442170FBLN1chr2245942965+1667473256957233
ENST00000396000PPARAchr2246594488+ENST00000340923FBLN1chr2245942965+1490473256852198
ENST00000262735PPARAchr2246594488+ENST00000348697FBLN1chr2245942965+18693901731180335
ENST00000262735PPARAchr2246594488+ENST00000402984FBLN1chr2245942965+12073901731120315
ENST00000262735PPARAchr2246594488+ENST00000262722FBLN1chr2245942965+12173901731120315
ENST00000262735PPARAchr2246594488+ENST00000327858FBLN1chr2245942965+18703901731180335
ENST00000262735PPARAchr2246594488+ENST00000442170FBLN1chr2245942965+1584390173874233
ENST00000262735PPARAchr2246594488+ENST00000340923FBLN1chr2245942965+1407390173769198
ENST00000407236PPARAchr2246594488+ENST00000348697FBLN1chr2245942965+19004212041211335
ENST00000407236PPARAchr2246594488+ENST00000402984FBLN1chr2245942965+12384212041151315
ENST00000407236PPARAchr2246594488+ENST00000262722FBLN1chr2245942965+12484212041151315
ENST00000407236PPARAchr2246594488+ENST00000327858FBLN1chr2245942965+19014212041211335
ENST00000407236PPARAchr2246594488+ENST00000442170FBLN1chr2245942965+1615421204905233
ENST00000407236PPARAchr2246594488+ENST00000340923FBLN1chr2245942965+1438421204800198
ENST00000402126PPARAchr2246594488+ENST00000348697FBLN1chr2245942965+18153361191126335
ENST00000402126PPARAchr2246594488+ENST00000402984FBLN1chr2245942965+11533361191066315
ENST00000402126PPARAchr2246594488+ENST00000262722FBLN1chr2245942965+11633361191066315
ENST00000402126PPARAchr2246594488+ENST00000327858FBLN1chr2245942965+18163361191126335
ENST00000402126PPARAchr2246594488+ENST00000442170FBLN1chr2245942965+1530336119820233
ENST00000402126PPARAchr2246594488+ENST00000340923FBLN1chr2245942965+1353336119715198
ENST00000434345PPARAchr2246594488+ENST00000348697FBLN1chr2245942965+16872080998332
ENST00000434345PPARAchr2246594488+ENST00000402984FBLN1chr2245942965+10252080938312
ENST00000434345PPARAchr2246594488+ENST00000262722FBLN1chr2245942965+10352080938312
ENST00000434345PPARAchr2246594488+ENST00000327858FBLN1chr2245942965+16882080998332
ENST00000434345PPARAchr2246594488+ENST00000442170FBLN1chr2245942965+14022080692230
ENST00000434345PPARAchr2246594488+ENST00000340923FBLN1chr2245942965+12252080587195

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000396000ENST00000348697PPARAchr2246594488+FBLN1chr2245942965+0.0008885690.9991115
ENST00000396000ENST00000402984PPARAchr2246594488+FBLN1chr2245942965+0.0119480270.988052
ENST00000396000ENST00000262722PPARAchr2246594488+FBLN1chr2245942965+0.0112069350.9887931
ENST00000396000ENST00000327858PPARAchr2246594488+FBLN1chr2245942965+0.001146730.9988532
ENST00000396000ENST00000442170PPARAchr2246594488+FBLN1chr2245942965+0.0038418230.9961582
ENST00000396000ENST00000340923PPARAchr2246594488+FBLN1chr2245942965+0.0022023760.9977976
ENST00000262735ENST00000348697PPARAchr2246594488+FBLN1chr2245942965+0.0010151330.9989849
ENST00000262735ENST00000402984PPARAchr2246594488+FBLN1chr2245942965+0.0169729980.98302704
ENST00000262735ENST00000262722PPARAchr2246594488+FBLN1chr2245942965+0.0160089580.983991
ENST00000262735ENST00000327858PPARAchr2246594488+FBLN1chr2245942965+0.0014036170.9985964
ENST00000262735ENST00000442170PPARAchr2246594488+FBLN1chr2245942965+0.0031681440.99683183
ENST00000262735ENST00000340923PPARAchr2246594488+FBLN1chr2245942965+0.0019833970.9980166
ENST00000407236ENST00000348697PPARAchr2246594488+FBLN1chr2245942965+0.0011856450.99881434
ENST00000407236ENST00000402984PPARAchr2246594488+FBLN1chr2245942965+0.0176249030.9823751
ENST00000407236ENST00000262722PPARAchr2246594488+FBLN1chr2245942965+0.0164936740.9835064
ENST00000407236ENST00000327858PPARAchr2246594488+FBLN1chr2245942965+0.0015297790.99847025
ENST00000407236ENST00000442170PPARAchr2246594488+FBLN1chr2245942965+0.0042062550.9957937
ENST00000407236ENST00000340923PPARAchr2246594488+FBLN1chr2245942965+0.0029951360.9970048
ENST00000402126ENST00000348697PPARAchr2246594488+FBLN1chr2245942965+0.0009914070.9990086
ENST00000402126ENST00000402984PPARAchr2246594488+FBLN1chr2245942965+0.0193908050.98060924
ENST00000402126ENST00000262722PPARAchr2246594488+FBLN1chr2245942965+0.0180217250.98197824
ENST00000402126ENST00000327858PPARAchr2246594488+FBLN1chr2245942965+0.0012985170.99870145
ENST00000402126ENST00000442170PPARAchr2246594488+FBLN1chr2245942965+0.0038980910.99610186
ENST00000402126ENST00000340923PPARAchr2246594488+FBLN1chr2245942965+0.0027541260.9972459
ENST00000434345ENST00000348697PPARAchr2246594488+FBLN1chr2245942965+0.0007410040.99925894
ENST00000434345ENST00000402984PPARAchr2246594488+FBLN1chr2245942965+0.0193991640.9806009
ENST00000434345ENST00000262722PPARAchr2246594488+FBLN1chr2245942965+0.0178099370.98219
ENST00000434345ENST00000327858PPARAchr2246594488+FBLN1chr2245942965+0.0010489840.99895096
ENST00000434345ENST00000442170PPARAchr2246594488+FBLN1chr2245942965+0.0033661770.9966338
ENST00000434345ENST00000340923PPARAchr2246594488+FBLN1chr2245942965+0.0018358110.99816424

check button Predicted full-length fusion amino acid sequences. For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among all the predicted ones.

Get the fusion protein sequences from here.

Fusion protein sequence information is available in the fasta format.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

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Fusion Protein Breakpoint Sequences for PPARA-FBLN1

check button +/-13 AA sequence from the breakpoints of the fusion protein sequences.
HgeneHchrHbpTgeneTchrTbpLength(fusion protein)BP in fusion proteinPeptide
PPARAchr2246594488FBLN1chr224594296520856DSSGSFGFTEYQYLGSCPGSDGSVIT
PPARAchr2246594488FBLN1chr224594296533659DSSGSFGFTEYQYLGSCPGSDGSVIT
PPARAchr2246594488FBLN1chr224594296539059DSSGSFGFTEYQYLGSCPGSDGSVIT
PPARAchr2246594488FBLN1chr224594296542159DSSGSFGFTEYQYLGSCPGSDGSVIT
PPARAchr2246594488FBLN1chr224594296547359DSSGSFGFTEYQYLGSCPGSDGSVIT

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Potential FusionNeoAntigen Information of PPARA-FBLN1 in HLA I

check button Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.
PPARA-FBLN1_46594488_45942965.msa

check button Potential FusionNeoAntigen Information
* We used NetMHCpan v4.1 (%rank<0.5) and deepHLApan v1.1 (immunogenic score>0.5)
Fusion geneHchrHbpTgeneTchrTbpHLA IFusionNeoAntigen peptideBinding scoreImmunogenic scoreNeoantigen start (at BP 13)Neoantigen end (at BP 13)
PPARA-FBLN1chr2246594488chr2245942965390HLA-B50:01TEYQYLGSC0.03640.5868817
PPARA-FBLN1chr2246594488chr2245942965390HLA-C03:08FGFTEYQYL0.99790.8926514
PPARA-FBLN1chr2246594488chr2245942965390HLA-C03:19FGFTEYQYL0.99780.995514
PPARA-FBLN1chr2246594488chr2245942965390HLA-C03:07FGFTEYQYL0.99770.9915514
PPARA-FBLN1chr2246594488chr2245942965390HLA-B40:06TEYQYLGSC0.97260.5818817
PPARA-FBLN1chr2246594488chr2245942965390HLA-C04:06FGFTEYQYL0.94570.8298514
PPARA-FBLN1chr2246594488chr2245942965390HLA-C08:13FGFTEYQYL0.92340.9576514
PPARA-FBLN1chr2246594488chr2245942965390HLA-C08:04FGFTEYQYL0.92340.9576514
PPARA-FBLN1chr2246594488chr2245942965390HLA-C06:03FGFTEYQYL0.90670.9969514
PPARA-FBLN1chr2246594488chr2245942965390HLA-C07:29FGFTEYQYL0.81790.8967514
PPARA-FBLN1chr2246594488chr2245942965390HLA-C07:13FGFTEYQYL0.80630.8926514
PPARA-FBLN1chr2246594488chr2245942965390HLA-C08:03FGFTEYQYL0.77560.9861514
PPARA-FBLN1chr2246594488chr2245942965390HLA-C02:06FGFTEYQYL0.72120.9922514
PPARA-FBLN1chr2246594488chr2245942965390HLA-C03:03FGFTEYQYL0.99830.9946514
PPARA-FBLN1chr2246594488chr2245942965390HLA-C03:04FGFTEYQYL0.99830.9946514
PPARA-FBLN1chr2246594488chr2245942965390HLA-C03:17FGFTEYQYL0.99610.9847514
PPARA-FBLN1chr2246594488chr2245942965390HLA-C03:05FGFTEYQYL0.9960.9563514
PPARA-FBLN1chr2246594488chr2245942965390HLA-C03:67FGFTEYQYL0.99430.9898514
PPARA-FBLN1chr2246594488chr2245942965390HLA-C03:06FGFTEYQYL0.93820.9954514
PPARA-FBLN1chr2246594488chr2245942965390HLA-C08:01FGFTEYQYL0.77560.9861514
PPARA-FBLN1chr2246594488chr2245942965390HLA-C17:01FGFTEYQYL0.7590.9311514
PPARA-FBLN1chr2246594488chr2245942965390HLA-C06:08FGFTEYQYL0.6280.9966514
PPARA-FBLN1chr2246594488chr2245942965390HLA-B50:05TEYQYLGSC0.03640.5868817
PPARA-FBLN1chr2246594488chr2245942965390HLA-B50:04TEYQYLGSC0.03640.5868817

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Potential FusionNeoAntigen Information of PPARA-FBLN1 in HLA II

check button Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.

check button Potential FusionNeoAntigen Information
* We used NetMHCIIpan v4.1 (%rank<0.5).
Fusion geneHchrHbpTgeneTchrTbpHLA IIFusionNeoAntigen peptideNeoantigen start (at BP 13)Neoantigen end (at BP 13)

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Fusion breakpoint peptide structures of PPARA-FBLN1

check button3D structures of the fusion breakpoint peptide of 14AA sequence that have potential fusion neoantigens
* The minimum length of the amino acid sequence in RoseTTAFold is 14AA. Here, we predicted the 14AA fusion protein breakpoint sequence not the fusion neoantigen peptide, which is shorter than 14 AA.
File nameBPseqHgeneTgeneHchrHbpTchrTbpAAlen
2788GFTEYQYLGSCPGSPPARAFBLN1chr2246594488chr2245942965390

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Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D of PPARA-FBLN1

check buttonVirtual screening between 25 HLAs (from PDB) and FusionNeoAntigens
* We used Glide to predict the interaction between HLAs and neoantigens.
HLA allelePDB IDFile nameBPseqDocking scoreGlide score
HLA-B14:023BVN2788GFTEYQYLGSCPGS-7.02924-7.14264
HLA-B14:023BVN2788GFTEYQYLGSCPGS-3.38077-4.41607
HLA-B52:013W392788GFTEYQYLGSCPGS-6.41355-6.52695
HLA-B52:013W392788GFTEYQYLGSCPGS-4.44188-5.47718
HLA-A24:025HGA2788GFTEYQYLGSCPGS-7.76595-8.80125
HLA-A24:025HGA2788GFTEYQYLGSCPGS-7.30892-7.42232
HLA-B44:053DX82788GFTEYQYLGSCPGS-5.65486-5.76826
HLA-B44:053DX82788GFTEYQYLGSCPGS-2.95775-3.99305

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Vaccine Design for the FusionNeoAntigens of PPARA-FBLN1

check button mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-Is.
Fusion geneHchrHbpTchrTbpStart in +/-13AAEnd in +/-13AAFusionNeoAntigen peptide sequenceFusionNeoAntigen RNA sequence
PPARA-FBLN1chr2246594488chr2245942965514FGFTEYQYLGCTCAGATGGCTCGGTCATCACGGACA
PPARA-FBLN1chr2246594488chr2245942965817TEYQYLGSCGCTCGGTCATCACGGACATCAATGAGT

check button mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-IIs.
Fusion geneHchrHbpTchrTbpStart in +/-13AAEnd in +/-13AAFusionNeoAntigen peptideFusionNEoAntigen RNA sequence

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Information of the samples that have these potential fusion neoantigens of PPARA-FBLN1

check button These samples were reported as having these fusion breakpoints. For individual breakpoints, we checked the open reading frames considering multiple gene isoforms and chose the in-frame fusion genes only. Then, we made fusion protein sequences and predicted the fusion neoantigens. These fusion-positive samples may have these potential fusion neoantigens.
Cancer typeFusion geneHchrHbpHenstTchrTbpTenstSample
BRCAPPARA-FBLN1chr2246594488ENST00000262735chr2245942965ENST00000262722TCGA-UU-A93S-01A

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Potential target of CAR-T therapy development for PPARA-FBLN1

check button Predicted 3D structure. We used RoseTTAFold.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, to provide the retention of the transmembrane domain, we only show the protein feature retention information of those transmembrane features


* Minus value of BPloci means that the break point is located before the CDS.
- In-frame and retained 'Transmembrane'.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

check button Subcellular localization prediction of the transmembrane domain retained fusion proteins
* We used DeepLoc 1.0. The order of the X-axis of the barplot is as follows: Entry_ID, Localization, Type, Nucleus, Cytoplasm, Extracellular, Mitochondrion, Cell_membrane, Endoplasmic_reticulum, Plastid, Golgi.apparatus, Lysosome.Vacuole, Peroxisome. Y-axis is the output score of DeepLoc. Clicking the image will open a new tab with a large image.
HgeneHchrHbpHenstTgeneTchrTbpTenstDeepLoc result

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Related Drugs to PPARA-FBLN1

check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to PPARA-FBLN1

check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource