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Center for Computational Systems Medicine
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Fusion Gene and Fusion Protein Summary

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Fusion Amino Acid Sequences (multiple BPs and multiple gene isoforms)

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Fusion Protein Breakpoint Sequences - (for the Screening of the FusionNeoAntigens)

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Potential FusionNeoAntigens in HLA I - (netMHCpan v4.1 + deepHLApan v1.1)

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Potential FusionNeoAntigens in HLA II - (netMHCIIpan v4.1)

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Fusion Breakpoint 14 AA Peptide Structure - (RoseTTAFold)

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Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D - (Glide)

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Vaccine Design for the FusionNeoAntigens (RNA/protein sequences)

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Potential target of CAR-T therapy development

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Information on the samples that have these potential fusion neoantigens

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Fusion Protein Targeting Drugs - (Manual Curation)

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Fusion Protein Related diseases - (Manual Curation)

Fusion Protein:PPP6R3-MARK2

Fusion Gene and Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: PPP6R3-MARK2
FusionPDB ID: 68307
FusionGDB2.0 ID: 68307
HgeneTgene
Gene symbol

PPP6R3

MARK2

Gene ID

55291

2011

Gene nameprotein phosphatase 6 regulatory subunit 3microtubule affinity regulating kinase 2
SynonymsC11orf23|PP6R3|SAP190|SAPL|SAPLa|SAPS3EMK-1|EMK1|PAR-1|Par-1b|Par1b
Cytomap

11q13.2

11q13.1

Type of geneprotein-codingprotein-coding
Descriptionserine/threonine-protein phosphatase 6 regulatory subunit 3SAPS domain family, member 3sporulation-induced transcript 4-associated protein SAPLserine/threonine-protein kinase MARK2ELKL motif kinase 1MAP/microtubule affinity-regulating kinase 2PAR1 homolog bSer/Thr protein kinase PAR-1Bserine/threonine protein kinase EMKtesticular tissue protein Li 117
Modification date2020031320200329
UniProtAcc.

Q7KZI7

Main function of 5'-partner protein: FUNCTION: Serine/threonine-protein kinase (PubMed:23666762). Involved in cell polarity and microtubule dynamics regulation. Phosphorylates CRTC2/TORC2, DCX, HDAC7, KIF13B, MAP2, MAP4 and RAB11FIP2. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Plays a key role in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Regulates epithelial cell polarity by phosphorylating RAB11FIP2. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Regulates axogenesis by phosphorylating KIF13B, promoting interaction between KIF13B and 14-3-3 and inhibiting microtubule-dependent accumulation of KIF13B. Also required for neurite outgrowth and establishment of neuronal polarity. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3). Modulates the developmental decision to build a columnar versus a hepatic epithelial cell apparently by promoting a switch from a direct to a transcytotic mode of apical protein delivery. Essential for the asymmetric development of membrane domains of polarized epithelial cells. {ECO:0000269|PubMed:11433294, ECO:0000269|PubMed:12429843, ECO:0000269|PubMed:14976552, ECO:0000269|PubMed:15158914, ECO:0000269|PubMed:15324659, ECO:0000269|PubMed:15365179, ECO:0000269|PubMed:16775013, ECO:0000269|PubMed:16980613, ECO:0000269|PubMed:18626018, ECO:0000269|PubMed:20194617, ECO:0000269|PubMed:23666762}.
Ensembl transtripts involved in fusion geneENST idsENST00000265636, ENST00000265637, 
ENST00000393799, ENST00000393800, 
ENST00000393801, ENST00000524845, 
ENST00000524904, ENST00000527403, 
ENST00000529710, ENST00000534534, 
ENST00000530427, 		ENST00000315032, 
ENST00000350490, ENST00000361128, 
ENST00000377810, ENST00000502399, 
ENST00000508192, ENST00000509502, 
ENST00000513765, ENST00000408948, 
ENST00000425897, ENST00000377809, 
ENST00000402010, ENST00000413835, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score34 X 21 X 15=107107 X 6 X 3=126
# samples 4310
** MAII scorelog2(43/10710*10)=-4.63847801004816
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/126*10)=-0.333423733725192
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Fusion gene context

PubMed: PPP6R3 [Title/Abstract] AND MARK2 [Title/Abstract] AND fusion [Title/Abstract]

Fusion neoantigen context

PubMed: PPP6R3 [Title/Abstract] AND MARK2 [Title/Abstract] AND neoantigen [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)PPP6R3(68343511)-MARK2(63662631), # samples:2
Anticipated loss of major functional domain due to fusion event.PPP6R3-MARK2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
PPP6R3-MARK2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePPP6R3

GO:0043666

regulation of phosphoprotein phosphatase activity

16716191

TgeneMARK2

GO:0006468

protein phosphorylation

14976552

TgeneMARK2

GO:0010976

positive regulation of neuron projection development

12429843

TgeneMARK2

GO:0018105

peptidyl-serine phosphorylation

10542369|16717194

TgeneMARK2

GO:0030010

establishment of cell polarity

12429843

TgeneMARK2

GO:0035556

intracellular signal transduction

14976552

TgeneMARK2

GO:0045197

establishment or maintenance of epithelial cell apical/basal polarity

15324659

TgeneMARK2

GO:0070507

regulation of microtubule cytoskeleton organization

10542369



check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:68343511/chr11:63662631)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonRetention analysis results of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features, are available here.

check buttonFusion gene breakpoints across PPP6R3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across MARK2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Amino Acid Sequences


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000393799PPP6R3chr1168343511+ENST00000377809MARK2chr1163662631+5862181226740791270
ENST00000393799PPP6R3chr1168343511+ENST00000402010MARK2chr1163662631+5907181226741241285
ENST00000393799PPP6R3chr1168343511+ENST00000413835MARK2chr1163662631+5745181226739621231
ENST00000393800PPP6R3chr1168343511+ENST00000377809MARK2chr1163662631+5849179925440661270
ENST00000393800PPP6R3chr1168343511+ENST00000402010MARK2chr1163662631+5894179925441111285
ENST00000393800PPP6R3chr1168343511+ENST00000413835MARK2chr1163662631+5732179925439491231
ENST00000534534PPP6R3chr1168343511+ENST00000377809MARK2chr1163662631+5176112625333931046
ENST00000534534PPP6R3chr1168343511+ENST00000402010MARK2chr1163662631+5221112625334381061
ENST00000534534PPP6R3chr1168343511+ENST00000413835MARK2chr1163662631+5059112625332761007
ENST00000524845PPP6R3chr1168343511+ENST00000377809MARK2chr1163662631+5831178123640481270
ENST00000524845PPP6R3chr1168343511+ENST00000402010MARK2chr1163662631+5876178123640931285
ENST00000524845PPP6R3chr1168343511+ENST00000413835MARK2chr1163662631+5714178123639311231
ENST00000265637PPP6R3chr1168343511+ENST00000377809MARK2chr1163662631+567716278238941270
ENST00000265637PPP6R3chr1168343511+ENST00000402010MARK2chr1163662631+572216278239391285
ENST00000265637PPP6R3chr1168343511+ENST00000413835MARK2chr1163662631+556016278237771231
ENST00000524904PPP6R3chr1168343511+ENST00000377809MARK2chr1163662631+5825177523040421270
ENST00000524904PPP6R3chr1168343511+ENST00000402010MARK2chr1163662631+5870177523040871285
ENST00000524904PPP6R3chr1168343511+ENST00000413835MARK2chr1163662631+5708177523039251231
ENST00000393801PPP6R3chr1168343511+ENST00000377809MARK2chr1163662631+5810176021540271270
ENST00000393801PPP6R3chr1168343511+ENST00000402010MARK2chr1163662631+5855176021540721285
ENST00000393801PPP6R3chr1168343511+ENST00000413835MARK2chr1163662631+5693176021539101231
ENST00000265636PPP6R3chr1168343511+ENST00000377809MARK2chr1163662631+5719166927739361219
ENST00000265636PPP6R3chr1168343511+ENST00000402010MARK2chr1163662631+5764166927739811234
ENST00000265636PPP6R3chr1168343511+ENST00000413835MARK2chr1163662631+5602166927738191180
ENST00000529710PPP6R3chr1168343511+ENST00000377809MARK2chr1163662631+5719166927739361219
ENST00000529710PPP6R3chr1168343511+ENST00000402010MARK2chr1163662631+5764166927739811234
ENST00000529710PPP6R3chr1168343511+ENST00000413835MARK2chr1163662631+5602166927738191180
ENST00000527403PPP6R3chr1168343511+ENST00000377809MARK2chr1163662631+5747169715239641270
ENST00000527403PPP6R3chr1168343511+ENST00000402010MARK2chr1163662631+5792169715240091285
ENST00000527403PPP6R3chr1168343511+ENST00000413835MARK2chr1163662631+5630169715238471231

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000393799ENST00000377809PPP6R3chr1168343511+MARK2chr1163662631+0.0016718020.99832815
ENST00000393799ENST00000402010PPP6R3chr1168343511+MARK2chr1163662631+0.0012596380.9987404
ENST00000393799ENST00000413835PPP6R3chr1168343511+MARK2chr1163662631+0.0009546470.9990453
ENST00000393800ENST00000377809PPP6R3chr1168343511+MARK2chr1163662631+0.0015966110.9984034
ENST00000393800ENST00000402010PPP6R3chr1168343511+MARK2chr1163662631+0.0012035480.99879646
ENST00000393800ENST00000413835PPP6R3chr1168343511+MARK2chr1163662631+0.0009062210.9990938
ENST00000534534ENST00000377809PPP6R3chr1168343511+MARK2chr1163662631+0.0013644890.9986355
ENST00000534534ENST00000402010PPP6R3chr1168343511+MARK2chr1163662631+0.0013687180.9986313
ENST00000534534ENST00000413835PPP6R3chr1168343511+MARK2chr1163662631+0.000713540.9992865
ENST00000524845ENST00000377809PPP6R3chr1168343511+MARK2chr1163662631+0.0015849880.998415
ENST00000524845ENST00000402010PPP6R3chr1168343511+MARK2chr1163662631+0.0011948520.99880517
ENST00000524845ENST00000413835PPP6R3chr1168343511+MARK2chr1163662631+0.0009005090.9990995
ENST00000265637ENST00000377809PPP6R3chr1168343511+MARK2chr1163662631+0.0014943410.9985057
ENST00000265637ENST00000402010PPP6R3chr1168343511+MARK2chr1163662631+0.0011303510.9988696
ENST00000265637ENST00000413835PPP6R3chr1168343511+MARK2chr1163662631+0.0008728790.9991271
ENST00000524904ENST00000377809PPP6R3chr1168343511+MARK2chr1163662631+0.0015935180.99840647
ENST00000524904ENST00000402010PPP6R3chr1168343511+MARK2chr1163662631+0.0012012360.9987987
ENST00000524904ENST00000413835PPP6R3chr1168343511+MARK2chr1163662631+0.0009079460.9990921
ENST00000393801ENST00000377809PPP6R3chr1168343511+MARK2chr1163662631+0.0016129040.9983871
ENST00000393801ENST00000402010PPP6R3chr1168343511+MARK2chr1163662631+0.0012153820.9987846
ENST00000393801ENST00000413835PPP6R3chr1168343511+MARK2chr1163662631+0.0009242950.99907565
ENST00000265636ENST00000377809PPP6R3chr1168343511+MARK2chr1163662631+0.0019940830.9980059
ENST00000265636ENST00000402010PPP6R3chr1168343511+MARK2chr1163662631+0.0010138850.99898607
ENST00000265636ENST00000413835PPP6R3chr1168343511+MARK2chr1163662631+0.0008196170.9991804
ENST00000529710ENST00000377809PPP6R3chr1168343511+MARK2chr1163662631+0.0019940830.9980059
ENST00000529710ENST00000402010PPP6R3chr1168343511+MARK2chr1163662631+0.0010138850.99898607
ENST00000529710ENST00000413835PPP6R3chr1168343511+MARK2chr1163662631+0.0008196170.9991804
ENST00000527403ENST00000377809PPP6R3chr1168343511+MARK2chr1163662631+0.0015445080.9984555
ENST00000527403ENST00000402010PPP6R3chr1168343511+MARK2chr1163662631+0.0011642410.99883574
ENST00000527403ENST00000413835PPP6R3chr1168343511+MARK2chr1163662631+0.0008882660.9991117

check button Predicted full-length fusion amino acid sequences. For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among all the predicted ones.

Get the fusion protein sequences from here.

Fusion protein sequence information is available in the fasta format.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

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Fusion Protein Breakpoint Sequences for PPP6R3-MARK2

check button +/-13 AA sequence from the breakpoints of the fusion protein sequences.
HgeneHchrHbpTgeneTchrTbpLength(fusion protein)BP in fusion proteinPeptide
PPP6R3chr1168343511MARK2chr11636626311126291SLGETNKRNTVDLPTLGHLDSKPSSK
PPP6R3chr1168343511MARK2chr11636626311627515SLGETNKRNTVDLPTLGHLDSKPSSK
PPP6R3chr1168343511MARK2chr11636626311669464SLGETNKRNTVDLPTLGHLDSKPSSK
PPP6R3chr1168343511MARK2chr11636626311697515SLGETNKRNTVDLPTLGHLDSKPSSK
PPP6R3chr1168343511MARK2chr11636626311760515SLGETNKRNTVDLPTLGHLDSKPSSK
PPP6R3chr1168343511MARK2chr11636626311775515SLGETNKRNTVDLPTLGHLDSKPSSK
PPP6R3chr1168343511MARK2chr11636626311781515SLGETNKRNTVDLPTLGHLDSKPSSK
PPP6R3chr1168343511MARK2chr11636626311799515SLGETNKRNTVDLPTLGHLDSKPSSK
PPP6R3chr1168343511MARK2chr11636626311812515SLGETNKRNTVDLPTLGHLDSKPSSK

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Potential FusionNeoAntigen Information of PPP6R3-MARK2 in HLA I

check button Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.
PPP6R3-MARK2_68343511_63662631.msa

check button Potential FusionNeoAntigen Information
* We used NetMHCpan v4.1 (%rank<0.5) and deepHLApan v1.1 (immunogenic score>0.5)
Fusion geneHchrHbpTgeneTchrTbpHLA IFusionNeoAntigen peptideBinding scoreImmunogenic scoreNeoantigen start (at BP 13)Neoantigen end (at BP 13)
PPP6R3-MARK2chr1168343511chr11636626311669HLA-B27:05KRNTVDLPTL0.99990.7376616
PPP6R3-MARK2chr1168343511chr11636626311669HLA-B27:04KRNTVDLPTL0.99980.6112616
PPP6R3-MARK2chr1168343511chr11636626311669HLA-C05:09TVDLPTLGHL0.99990.9887919
PPP6R3-MARK2chr1168343511chr11636626311669HLA-B27:14KRNTVDLPTL0.99990.6587616
PPP6R3-MARK2chr1168343511chr11636626311669HLA-C08:15TVDLPTLGHL0.99990.9945919
PPP6R3-MARK2chr1168343511chr11636626311669HLA-B27:03KRNTVDLPTL0.99690.7824616
PPP6R3-MARK2chr1168343511chr11636626311669HLA-A02:07TVDLPTLGHL0.69070.6552919
PPP6R3-MARK2chr1168343511chr11636626311669HLA-C08:02TVDLPTLGHL0.99990.9945919
PPP6R3-MARK2chr1168343511chr11636626311669HLA-C04:03TVDLPTLGHL0.99990.9808919
PPP6R3-MARK2chr1168343511chr11636626311669HLA-C05:01TVDLPTLGHL0.99990.9887919
PPP6R3-MARK2chr1168343511chr11636626311669HLA-B27:08KRNTVDLPTL0.99980.5882616
PPP6R3-MARK2chr1168343511chr11636626311669HLA-B27:10KRNTVDLPTL0.99980.7929616
PPP6R3-MARK2chr1168343511chr11636626311669HLA-B27:06KRNTVDLPTL0.99960.6178616
PPP6R3-MARK2chr1168343511chr11636626311669HLA-B27:09KRNTVDLPTL0.99940.7099616

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Potential FusionNeoAntigen Information of PPP6R3-MARK2 in HLA II

check button Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.

check button Potential FusionNeoAntigen Information
* We used NetMHCIIpan v4.1 (%rank<0.5).
Fusion geneHchrHbpTgeneTchrTbpHLA IIFusionNeoAntigen peptideNeoantigen start (at BP 13)Neoantigen end (at BP 13)

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Fusion breakpoint peptide structures of PPP6R3-MARK2

check button3D structures of the fusion breakpoint peptide of 14AA sequence that have potential fusion neoantigens
* The minimum length of the amino acid sequence in RoseTTAFold is 14AA. Here, we predicted the 14AA fusion protein breakpoint sequence not the fusion neoantigen peptide, which is shorter than 14 AA.
File nameBPseqHgeneTgeneHchrHbpTchrTbpAAlen
4571KRNTVDLPTLGHLDPPP6R3MARK2chr1168343511chr11636626311669

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Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D of PPP6R3-MARK2

check buttonVirtual screening between 25 HLAs (from PDB) and FusionNeoAntigens
* We used Glide to predict the interaction between HLAs and neoantigens.
HLA allelePDB IDFile nameBPseqDocking scoreGlide score
HLA-B14:023BVN4571KRNTVDLPTLGHLD-7.15543-7.26883
HLA-B14:023BVN4571KRNTVDLPTLGHLD-4.77435-5.80965
HLA-B52:013W394571KRNTVDLPTLGHLD-6.80875-6.92215
HLA-B52:013W394571KRNTVDLPTLGHLD-4.20386-5.23916
HLA-A11:014UQ24571KRNTVDLPTLGHLD-7.5194-8.5547
HLA-A11:014UQ24571KRNTVDLPTLGHLD-6.9601-7.0735
HLA-A24:025HGA4571KRNTVDLPTLGHLD-7.52403-7.63743
HLA-A24:025HGA4571KRNTVDLPTLGHLD-5.82433-6.85963
HLA-B27:056PYJ4571KRNTVDLPTLGHLD-3.28285-4.31815
HLA-B44:053DX84571KRNTVDLPTLGHLD-5.91172-6.94702
HLA-B44:053DX84571KRNTVDLPTLGHLD-4.24346-4.35686

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Vaccine Design for the FusionNeoAntigens of PPP6R3-MARK2

check button mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-Is.
Fusion geneHchrHbpTchrTbpStart in +/-13AAEnd in +/-13AAFusionNeoAntigen peptide sequenceFusionNeoAntigen RNA sequence
PPP6R3-MARK2chr1168343511chr1163662631616KRNTVDLPTLAAGAGGAACACGGTAGATCTACCCACCTTG
PPP6R3-MARK2chr1168343511chr1163662631919TVDLPTLGHLACGGTAGATCTACCCACCTTGGGACACCTT

check button mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-IIs.
Fusion geneHchrHbpTchrTbpStart in +/-13AAEnd in +/-13AAFusionNeoAntigen peptideFusionNEoAntigen RNA sequence

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Information of the samples that have these potential fusion neoantigens of PPP6R3-MARK2

check button These samples were reported as having these fusion breakpoints. For individual breakpoints, we checked the open reading frames considering multiple gene isoforms and chose the in-frame fusion genes only. Then, we made fusion protein sequences and predicted the fusion neoantigens. These fusion-positive samples may have these potential fusion neoantigens.
Cancer typeFusion geneHchrHbpHenstTchrTbpTenstSample
STADPPP6R3-MARK2chr1168343511ENST00000265636chr1163662631ENST00000377809TCGA-BR-6802-01A

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Potential target of CAR-T therapy development for PPP6R3-MARK2

check button Predicted 3D structure. We used RoseTTAFold.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, to provide the retention of the transmembrane domain, we only show the protein feature retention information of those transmembrane features


* Minus value of BPloci means that the break point is located before the CDS.
- In-frame and retained 'Transmembrane'.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

check button Subcellular localization prediction of the transmembrane domain retained fusion proteins
* We used DeepLoc 1.0. The order of the X-axis of the barplot is as follows: Entry_ID, Localization, Type, Nucleus, Cytoplasm, Extracellular, Mitochondrion, Cell_membrane, Endoplasmic_reticulum, Plastid, Golgi.apparatus, Lysosome.Vacuole, Peroxisome. Y-axis is the output score of DeepLoc. Clicking the image will open a new tab with a large image.
HgeneHchrHbpHenstTgeneTchrTbpTenstDeepLoc result

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Related Drugs to PPP6R3-MARK2

check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to PPP6R3-MARK2

check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource