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Fusion Protein:ASH1L-GON4L

Fusion Gene and Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: ASH1L-GON4L
	FusionPDB ID: 7093
	FusionGDB2.0 ID: 7093
		Hgene	Tgene
	Gene symbol	ASH1L	GON4L
	Gene ID	55870	54856
	Gene name	ASH1 like histone lysine methyltransferase	gon-4 like
	Synonyms	ASH1\|ASH1L1\|KMT2H\|MRD52	GON-4\|GON4\|YARP
	Cytomap	1q22	1q22
	Type of gene	protein-coding	protein-coding
	Description	histone-lysine N-methyltransferase ASH1LASH1-like proteinabsent small and homeotic disks protein 1 homologash1 (absent, small, or homeotic)-likelysine N-methyltransferase 2Hprobable histone-lysine N-methyltransferase ASH1L	GON-4-like protein2610100B20RikYY1AP related proteinYY1AP-related protein1gon-4 homolog
	Modification date	20200313	20200320
	UniProtAcc	Q9NR48 Main function of 5'-partner protein: FUNCTION: Histone methyltransferase specifically trimethylating 'Lys-36' of histone H3 forming H3K36me3 (PubMed:21239497). Also monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro (By similarity). The physiological significance of the H3K9me1 activity is unclear (By similarity). {ECO:0000250\|UniProtKB:Q99MY8, ECO:0000269\|PubMed:21239497}.	Q3T8J9 Main function of 5'-partner protein: FUNCTION: Has transcriptional repressor activity, probably as part of a complex with YY1, SIN3A AND HDAC1. Required for B cell lymphopoiesis. {ECO:0000250\|UniProtKB:Q9DB00}.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000368346, ENST00000392403, ENST00000548830,	ENST00000471341, ENST00000271883, ENST00000361040, ENST00000368331, ENST00000437809,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	36 X 20 X 14=10080	11 X 14 X 10=1540
	# samples	44	17
	** MAII score	log2(44/10080*10)=-4.51784830486262 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(17/1540*10)=-3.17932369944456 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Fusion gene context	PubMed: ASH1L [Title/Abstract] AND GON4L [Title/Abstract] AND fusion [Title/Abstract]
Fusion neoantigen context	PubMed: ASH1L [Title/Abstract] AND GON4L [Title/Abstract] AND neoantigen [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	ASH1L(155531944)-GON4L(155730432), # samples:2 ASH1L(155531944)-GON4L(155786053), # samples:2
Anticipated loss of major functional domain due to fusion event.	ASH1L-GON4L seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ASH1L-GON4L seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ASH1L-GON4L seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. ASH1L-GON4L seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	ASH1L	GO:0097676	histone H3-K36 dimethylation	26002201

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:155531944/chr1:155730432)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Retention analysis results of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features, are available here.

Fusion gene breakpoints across ASH1L (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across GON4L (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Amino Acid Sequences

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000368346	ASH1L	chr1	155385534	-	ENST00000437809	GON4L	chr1	155796819	-	13733	6648	6473	12865	2130
ENST00000368346	ASH1L	chr1	155385534	-	ENST00000368331	GON4L	chr1	155796819	-	13734	6648	6473	12868	2131
ENST00000368346	ASH1L	chr1	155385534	-	ENST00000271883	GON4L	chr1	155796819	-	13118	6648	6473	12865	2130
ENST00000368346	ASH1L	chr1	155385534	-	ENST00000361040	GON4L	chr1	155796819	-	11189	6648	640	6669	2009
ENST00000392403	ASH1L	chr1	155385534	-	ENST00000437809	GON4L	chr1	155796819	-	13572	6487	6312	12704	2130
ENST00000392403	ASH1L	chr1	155385534	-	ENST00000368331	GON4L	chr1	155796819	-	13573	6487	6312	12707	2131
ENST00000392403	ASH1L	chr1	155385534	-	ENST00000271883	GON4L	chr1	155796819	-	12957	6487	6312	12704	2130
ENST00000392403	ASH1L	chr1	155385534	-	ENST00000361040	GON4L	chr1	155796819	-	11028	6487	479	6508	2009

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000368346	ENST00000437809	ASH1L	chr1	155385534	-	GON4L	chr1	155796819	-	0.011826554	0.9881734
ENST00000368346	ENST00000368331	ASH1L	chr1	155385534	-	GON4L	chr1	155796819	-	0.010592154	0.9894078
ENST00000368346	ENST00000271883	ASH1L	chr1	155385534	-	GON4L	chr1	155796819	-	0.010737265	0.98926276
ENST00000368346	ENST00000361040	ASH1L	chr1	155385534	-	GON4L	chr1	155796819	-	0.001005716	0.9989943
ENST00000392403	ENST00000437809	ASH1L	chr1	155385534	-	GON4L	chr1	155796819	-	0.011944857	0.98805517
ENST00000392403	ENST00000368331	ASH1L	chr1	155385534	-	GON4L	chr1	155796819	-	0.01095208	0.98904794
ENST00000392403	ENST00000271883	ASH1L	chr1	155385534	-	GON4L	chr1	155796819	-	0.011288563	0.98871136
ENST00000392403	ENST00000361040	ASH1L	chr1	155385534	-	GON4L	chr1	155796819	-	0.000850173	0.9991498

Predicted full-length fusion amino acid sequences. For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among all the predicted ones.

Get the fusion protein sequences from here.

Fusion protein sequence information is available in the fasta format.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

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Fusion Protein Breakpoint Sequences for ASH1L-GON4L

+/-13 AA sequence from the breakpoints of the fusion protein sequences.

Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	Length(fusion protein)	BP in fusion protein	Peptide
ASH1L	chr1	155385534	GON4L	chr1	155796819	6487	59	KQGCILTFTKLQRKPQMNSEGEIPSL
ASH1L	chr1	155385534	GON4L	chr1	155796819	6648	59	KQGCILTFTKLQRKPQMNSEGEIPSL

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Potential FusionNeoAntigen Information of ASH1L-GON4L in HLA I

Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.

ASH1L-GON4L_155385534_155796819.msa

Potential FusionNeoAntigen Information
* We used NetMHCpan v4.1 (%rank<0.5) and deepHLApan v1.1 (immunogenic score>0.5)

Fusion gene	Hchr	Hbp	Tgene	Tchr	Tbp	HLA I	FusionNeoAntigen peptide	Binding score	Immunogenic score	Neoantigen start (at BP 13)	Neoantigen end (at BP 13)
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	HLA-A30:08	LTFTKLQRK	0.9915	0.5557	5	14
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	HLA-B14:01	TKLQRKPQM	0.9251	0.7749	8	17
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	HLA-B14:02	TKLQRKPQM	0.9251	0.7749	8	17
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	HLA-B14:03	TKLQRKPQM	0.3334	0.6919	8	17
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	HLA-A30:01	LTFTKLQRK	0.9909	0.6984	5	14

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Potential FusionNeoAntigen Information of ASH1L-GON4L in HLA II

ASH1L-GON4L_155385534_155796819.msa

Potential FusionNeoAntigen Information
* We used NetMHCIIpan v4.1 (%rank<0.5).

Fusion gene	Hchr	Hbp	Tgene	Tchr	Tbp	HLA II	FusionNeoAntigen peptide	Neoantigen start (at BP 13)	Neoantigen end (at BP 13)
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1101	ILTFTKLQRKPQMNS	4	19
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1101	CILTFTKLQRKPQMN	3	18
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1102	QGCILTFTKLQRKPQ	1	16
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1102	KQGCILTFTKLQRKP	0	15
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1102	GCILTFTKLQRKPQM	2	17
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1105	ILTFTKLQRKPQMNS	4	19
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1105	CILTFTKLQRKPQMN	3	18
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1108	ILTFTKLQRKPQMNS	4	19
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1108	CILTFTKLQRKPQMN	3	18
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1109	ILTFTKLQRKPQMNS	4	19
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1109	CILTFTKLQRKPQMN	3	18
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1110	ILTFTKLQRKPQMNS	4	19
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1110	CILTFTKLQRKPQMN	3	18
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1111	ILTFTKLQRKPQMNS	4	19
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1111	CILTFTKLQRKPQMN	3	18
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1112	ILTFTKLQRKPQMNS	4	19
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1112	CILTFTKLQRKPQMN	3	18
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1113	QGCILTFTKLQRKPQ	1	16
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1114	QGCILTFTKLQRKPQ	1	16
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1114	KQGCILTFTKLQRKP	0	15
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1115	ILTFTKLQRKPQMNS	4	19
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1115	CILTFTKLQRKPQMN	3	18
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1116	QGCILTFTKLQRKPQ	1	16
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1116	KQGCILTFTKLQRKP	0	15
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1116	GCILTFTKLQRKPQM	2	17
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1118	QGCILTFTKLQRKPQ	1	16
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1119	ILTFTKLQRKPQMNS	4	19
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1119	CILTFTKLQRKPQMN	3	18
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1120	QGCILTFTKLQRKPQ	1	16
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1120	KQGCILTFTKLQRKP	0	15
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1121	QGCILTFTKLQRKPQ	1	16
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1121	KQGCILTFTKLQRKP	0	15
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1121	GCILTFTKLQRKPQM	2	17
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1124	ILTFTKLQRKPQMNS	4	19
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1124	CILTFTKLQRKPQMN	3	18
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1127	ILTFTKLQRKPQMNS	4	19
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1127	CILTFTKLQRKPQMN	3	18
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1128	ILTFTKLQRKPQMNS	4	19
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1128	CILTFTKLQRKPQMN	3	18
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1129	ILTFTKLQRKPQMNS	4	19
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1129	CILTFTKLQRKPQMN	3	18
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1131	ILTFTKLQRKPQMNS	4	19
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1131	CILTFTKLQRKPQMN	3	18
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1132	ILTFTKLQRKPQMNS	4	19
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1132	CILTFTKLQRKPQMN	3	18
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1133	ILTFTKLQRKPQMNS	4	19
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1133	CILTFTKLQRKPQMN	3	18
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1134	QGCILTFTKLQRKPQ	1	16
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1136	QGCILTFTKLQRKPQ	1	16
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1136	KQGCILTFTKLQRKP	0	15
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1137	ILTFTKLQRKPQMNS	4	19
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1139	ILTFTKLQRKPQMNS	4	19
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1139	CILTFTKLQRKPQMN	3	18
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1148	QGCILTFTKLQRKPQ	1	16
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1148	KQGCILTFTKLQRKP	0	15
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1149	ILTFTKLQRKPQMNS	4	19
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1149	CILTFTKLQRKPQMN	3	18
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1151	ILTFTKLQRKPQMNS	4	19
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1151	CILTFTKLQRKPQMN	3	18
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1155	QGCILTFTKLQRKPQ	1	16
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1161	ILTFTKLQRKPQMNS	4	19
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1161	CILTFTKLQRKPQMN	3	18
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1162	ILTFTKLQRKPQMNS	4	19
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1162	CILTFTKLQRKPQMN	3	18
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1165	QGCILTFTKLQRKPQ	1	16
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1165	KQGCILTFTKLQRKP	0	15
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1165	GCILTFTKLQRKPQM	2	17
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1166	ILTFTKLQRKPQMNS	4	19
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1166	CILTFTKLQRKPQMN	3	18
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1168	QGCILTFTKLQRKPQ	1	16
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1170	QGCILTFTKLQRKPQ	1	16
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1170	KQGCILTFTKLQRKP	0	15
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1170	GCILTFTKLQRKPQM	2	17
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1172	ILTFTKLQRKPQMNS	4	19
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1172	CILTFTKLQRKPQMN	3	18
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1172	LTFTKLQRKPQMNSE	5	20
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1172	GCILTFTKLQRKPQM	2	17
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1174	ILTFTKLQRKPQMNS	4	19
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1174	CILTFTKLQRKPQMN	3	18
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1175	ILTFTKLQRKPQMNS	4	19
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1175	CILTFTKLQRKPQMN	3	18
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1180	ILTFTKLQRKPQMNS	4	19
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1180	CILTFTKLQRKPQMN	3	18
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1181	ILTFTKLQRKPQMNS	4	19
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1181	CILTFTKLQRKPQMN	3	18
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1182	QGCILTFTKLQRKPQ	1	16
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1186	QGCILTFTKLQRKPQ	1	16
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1186	KQGCILTFTKLQRKP	0	15
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1187	ILTFTKLQRKPQMNS	4	19
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1187	CILTFTKLQRKPQMN	3	18
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1190	ILTFTKLQRKPQMNS	4	19
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1190	CILTFTKLQRKPQMN	3	18
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1191	ILTFTKLQRKPQMNS	4	19
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1191	CILTFTKLQRKPQMN	3	18
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1193	ILTFTKLQRKPQMNS	4	19
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1193	CILTFTKLQRKPQMN	3	18
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1194	ILTFTKLQRKPQMNS	4	19
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1194	CILTFTKLQRKPQMN	3	18
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1195	ILTFTKLQRKPQMNS	4	19
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1195	CILTFTKLQRKPQMN	3	18
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1196	ILTFTKLQRKPQMNS	4	19
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1196	CILTFTKLQRKPQMN	3	18
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1301	QGCILTFTKLQRKPQ	1	16
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1301	KQGCILTFTKLQRKP	0	15
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1301	GCILTFTKLQRKPQM	2	17
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1302	QGCILTFTKLQRKPQ	1	16
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1302	KQGCILTFTKLQRKP	0	15
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1304	QGCILTFTKLQRKPQ	1	16
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1304	KQGCILTFTKLQRKP	0	15
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1305	ILTFTKLQRKPQMNS	4	19
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1305	CILTFTKLQRKPQMN	3	18
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1306	QGCILTFTKLQRKPQ	1	16
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1307	ILTFTKLQRKPQMNS	4	19
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1308	QGCILTFTKLQRKPQ	1	16
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1308	KQGCILTFTKLQRKP	0	15
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1309	QGCILTFTKLQRKPQ	1	16
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1309	KQGCILTFTKLQRKP	0	15
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1314	ILTFTKLQRKPQMNS	4	19
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1314	CILTFTKLQRKPQMN	3	18
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1315	QGCILTFTKLQRKPQ	1	16
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1315	KQGCILTFTKLQRKP	0	15
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1315	GCILTFTKLQRKPQM	2	17
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1316	QGCILTFTKLQRKPQ	1	16
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1316	KQGCILTFTKLQRKP	0	15
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1317	QGCILTFTKLQRKPQ	1	16
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1317	KQGCILTFTKLQRKP	0	15
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1317	GCILTFTKLQRKPQM	2	17
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1319	QGCILTFTKLQRKPQ	1	16
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1319	KQGCILTFTKLQRKP	0	15
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1320	QGCILTFTKLQRKPQ	1	16
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1320	KQGCILTFTKLQRKP	0	15
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1322	QGCILTFTKLQRKPQ	1	16
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1322	KQGCILTFTKLQRKP	0	15
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1322	GCILTFTKLQRKPQM	2	17
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1323	QGCILTFTKLQRKPQ	1	16
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1323	KQGCILTFTKLQRKP	0	15
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1326	ILTFTKLQRKPQMNS	4	19
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1326	CILTFTKLQRKPQMN	3	18
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1327	QGCILTFTKLQRKPQ	1	16
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1327	KQGCILTFTKLQRKP	0	15
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1327	GCILTFTKLQRKPQM	2	17
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1329	QGCILTFTKLQRKPQ	1	16
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1334	QGCILTFTKLQRKPQ	1	16
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1334	KQGCILTFTKLQRKP	0	15
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1335	QGCILTFTKLQRKPQ	1	16
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1335	KQGCILTFTKLQRKP	0	15
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1335	GCILTFTKLQRKPQM	2	17
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1339	QGCILTFTKLQRKPQ	1	16
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1339	KQGCILTFTKLQRKP	0	15
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1341	QGCILTFTKLQRKPQ	1	16
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1341	KQGCILTFTKLQRKP	0	15
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1343	QGCILTFTKLQRKPQ	1	16
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1343	KQGCILTFTKLQRKP	0	15
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1344	QGCILTFTKLQRKPQ	1	16
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1347	ILTFTKLQRKPQMNS	4	19
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1350	ILTFTKLQRKPQMNS	4	19
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1350	CILTFTKLQRKPQMN	3	18
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1351	QGCILTFTKLQRKPQ	1	16
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1351	KQGCILTFTKLQRKP	0	15
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1351	GCILTFTKLQRKPQM	2	17
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1352	QGCILTFTKLQRKPQ	1	16
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1352	KQGCILTFTKLQRKP	0	15
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1352	GCILTFTKLQRKPQM	2	17
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1353	QGCILTFTKLQRKPQ	1	16
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1353	KQGCILTFTKLQRKP	0	15
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1356	ILTFTKLQRKPQMNS	4	19
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1356	CILTFTKLQRKPQMN	3	18
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1357	QGCILTFTKLQRKPQ	1	16
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1357	KQGCILTFTKLQRKP	0	15
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1357	GCILTFTKLQRKPQM	2	17
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1359	QGCILTFTKLQRKPQ	1	16
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1359	KQGCILTFTKLQRKP	0	15
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1359	GCILTFTKLQRKPQM	2	17
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1361	QGCILTFTKLQRKPQ	1	16
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1361	KQGCILTFTKLQRKP	0	15
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1361	GCILTFTKLQRKPQM	2	17
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1362	ILTFTKLQRKPQMNS	4	19
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1362	CILTFTKLQRKPQMN	3	18
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1363	ILTFTKLQRKPQMNS	4	19
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1363	CILTFTKLQRKPQMN	3	18
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1364	QGCILTFTKLQRKPQ	1	16
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1364	KQGCILTFTKLQRKP	0	15
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1364	GCILTFTKLQRKPQM	2	17
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1368	QGCILTFTKLQRKPQ	1	16
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1368	KQGCILTFTKLQRKP	0	15
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1368	GCILTFTKLQRKPQM	2	17
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1369	QGCILTFTKLQRKPQ	1	16
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1369	KQGCILTFTKLQRKP	0	15
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1369	GCILTFTKLQRKPQM	2	17
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1370	QGCILTFTKLQRKPQ	1	16
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1370	KQGCILTFTKLQRKP	0	15
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1371	QGCILTFTKLQRKPQ	1	16
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1371	KQGCILTFTKLQRKP	0	15
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1372	QGCILTFTKLQRKPQ	1	16
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1372	KQGCILTFTKLQRKP	0	15
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1373	QGCILTFTKLQRKPQ	1	16
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1373	KQGCILTFTKLQRKP	0	15
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1374	QGCILTFTKLQRKPQ	1	16
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1374	KQGCILTFTKLQRKP	0	15
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1378	QGCILTFTKLQRKPQ	1	16
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1378	KQGCILTFTKLQRKP	0	15
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1379	QGCILTFTKLQRKPQ	1	16
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1379	KQGCILTFTKLQRKP	0	15
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1379	GCILTFTKLQRKPQM	2	17
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1380	QGCILTFTKLQRKPQ	1	16
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1380	KQGCILTFTKLQRKP	0	15
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1380	GCILTFTKLQRKPQM	2	17
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1382	ILTFTKLQRKPQMNS	4	19
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1382	CILTFTKLQRKPQMN	3	18
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1383	QGCILTFTKLQRKPQ	1	16
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1383	KQGCILTFTKLQRKP	0	15
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1383	GCILTFTKLQRKPQM	2	17
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1384	QGCILTFTKLQRKPQ	1	16
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1384	KQGCILTFTKLQRKP	0	15
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1387	QGCILTFTKLQRKPQ	1	16
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1387	KQGCILTFTKLQRKP	0	15
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1387	GCILTFTKLQRKPQM	2	17
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1391	QGCILTFTKLQRKPQ	1	16
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1391	KQGCILTFTKLQRKP	0	15
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1391	GCILTFTKLQRKPQM	2	17
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1392	QGCILTFTKLQRKPQ	1	16
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1392	KQGCILTFTKLQRKP	0	15
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1392	GCILTFTKLQRKPQM	2	17
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1393	QGCILTFTKLQRKPQ	1	16
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1393	KQGCILTFTKLQRKP	0	15
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1396	QGCILTFTKLQRKPQ	1	16
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1397	QGCILTFTKLQRKPQ	1	16
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1397	KQGCILTFTKLQRKP	0	15
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1398	QGCILTFTKLQRKPQ	1	16
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1398	KQGCILTFTKLQRKP	0	15
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1398	GCILTFTKLQRKPQM	2	17
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1399	QGCILTFTKLQRKPQ	1	16
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1399	KQGCILTFTKLQRKP	0	15
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1417	QGCILTFTKLQRKPQ	1	16
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1427	ILTFTKLQRKPQMNS	4	19
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1427	CILTFTKLQRKPQMN	3	18
ASH1L-GON4L	chr1	155385534	chr1	155796819	6648	DRB1-1437	QGCILTFTKLQRKPQ	1	16

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Fusion breakpoint peptide structures of ASH1L-GON4L

3D structures of the fusion breakpoint peptide of 14AA sequence that have potential fusion neoantigens
* The minimum length of the amino acid sequence in RoseTTAFold is 14AA. Here, we predicted the 14AA fusion protein breakpoint sequence not the fusion neoantigen peptide, which is shorter than 14 AA.

File name	BPseq	Hgene	Tgene	Hchr	Hbp	Tchr	Tbp	AAlen
9338	TFTKLQRKPQMNSE	ASH1L	GON4L	chr1	155385534	chr1	155796819	6648

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Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D of ASH1L-GON4L

Virtual screening between 25 HLAs (from PDB) and FusionNeoAntigens
* We used Glide to predict the interaction between HLAs and neoantigens.

HLA allele	PDB ID	File name	BPseq	Docking score	Glide score
HLA-B14:02	3BVN	9338	TFTKLQRKPQMNSE	-7.9962	-8.1096
HLA-B14:02	3BVN	9338	TFTKLQRKPQMNSE	-5.70842	-6.74372
HLA-B52:01	3W39	9338	TFTKLQRKPQMNSE	-6.83737	-6.95077
HLA-B52:01	3W39	9338	TFTKLQRKPQMNSE	-4.4836	-5.5189
HLA-A11:01	4UQ2	9338	TFTKLQRKPQMNSE	-10.0067	-10.1201
HLA-A11:01	4UQ2	9338	TFTKLQRKPQMNSE	-9.03915	-10.0745
HLA-A24:02	5HGA	9338	TFTKLQRKPQMNSE	-6.56204	-6.67544
HLA-A24:02	5HGA	9338	TFTKLQRKPQMNSE	-5.42271	-6.45801
HLA-B44:05	3DX8	9338	TFTKLQRKPQMNSE	-7.85648	-8.89178
HLA-B44:05	3DX8	9338	TFTKLQRKPQMNSE	-5.3978	-5.5112
HLA-A02:01	6TDR	9338	TFTKLQRKPQMNSE	-3.37154	-4.40684

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Vaccine Design for the FusionNeoAntigens of ASH1L-GON4L

mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-Is.

Fusion gene	Hchr	Hbp	Tchr	Tbp	Start in +/-13AA	End in +/-13AA	FusionNeoAntigen peptide sequence	FusionNeoAntigen RNA sequence
ASH1L-GON4L	chr1	155385534	chr1	155796819	5	14	LTFTKLQRK	TTCTGACGTTTACAAAACTACAGAGGA
ASH1L-GON4L	chr1	155385534	chr1	155796819	8	17	TKLQRKPQM	TTACAAAACTACAGAGGAAACCTCAAA

mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-IIs.

Fusion gene	Hchr	Hbp	Tchr	Tbp	Start in +/-13AA	End in +/-13AA	FusionNeoAntigen peptide	FusionNEoAntigen RNA sequence
ASH1L-GON4L	chr1	155385534	chr1	155796819	0	15	KQGCILTFTKLQRKP	GAAAGCAGGGCTGTATTCTGACGTTTACAAAACTACAGAGGAAAC
ASH1L-GON4L	chr1	155385534	chr1	155796819	1	16	QGCILTFTKLQRKPQ	AGCAGGGCTGTATTCTGACGTTTACAAAACTACAGAGGAAACCTC
ASH1L-GON4L	chr1	155385534	chr1	155796819	2	17	GCILTFTKLQRKPQM	AGGGCTGTATTCTGACGTTTACAAAACTACAGAGGAAACCTCAAA
ASH1L-GON4L	chr1	155385534	chr1	155796819	3	18	CILTFTKLQRKPQMN	GCTGTATTCTGACGTTTACAAAACTACAGAGGAAACCTCAAATGA
ASH1L-GON4L	chr1	155385534	chr1	155796819	4	19	ILTFTKLQRKPQMNS	GTATTCTGACGTTTACAAAACTACAGAGGAAACCTCAAATGAATT
ASH1L-GON4L	chr1	155385534	chr1	155796819	5	20	LTFTKLQRKPQMNSE	TTCTGACGTTTACAAAACTACAGAGGAAACCTCAAATGAATTCTG

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Information of the samples that have these potential fusion neoantigens of ASH1L-GON4L

These samples were reported as having these fusion breakpoints. For individual breakpoints, we checked the open reading frames considering multiple gene isoforms and chose the in-frame fusion genes only. Then, we made fusion protein sequences and predicted the fusion neoantigens. These fusion-positive samples may have these potential fusion neoantigens.

Cancer type	Fusion gene	Hchr	Hbp	Henst	Tchr	Tbp	Tenst	Sample
STAD	ASH1L-GON4L	chr1	155385534	ENST00000368346	chr1	155796819	ENST00000271883	TCGA-BR-6456

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Potential target of CAR-T therapy development for ASH1L-GON4L

Predicted 3D structure. We used RoseTTAFold.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, to provide the retention of the transmembrane domain, we only show the protein feature retention information of those transmembrane features

* Minus value of BPloci means that the break point is located before the CDS.

- In-frame and retained 'Transmembrane'.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Subcellular localization prediction of the transmembrane domain retained fusion proteins
* We used DeepLoc 1.0. The order of the X-axis of the barplot is as follows: Entry_ID, Localization, Type, Nucleus, Cytoplasm, Extracellular, Mitochondrion, Cell_membrane, Endoplasmic_reticulum, Plastid, Golgi.apparatus, Lysosome.Vacuole, Peroxisome. Y-axis is the output score of DeepLoc. Clicking the image will open a new tab with a large image.

Hgene

Hchr

Hbp

Henst

Tgene

Tchr

Tbp

Tenst

DeepLoc result

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Related Drugs to ASH1L-GON4L

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to ASH1L-GON4L

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source

	Fusion Gene and Fusion Protein Summary
	Fusion Amino Acid Sequences (multiple BPs and multiple gene isoforms)
	Fusion Protein Breakpoint Sequences - (for the Screening of the FusionNeoAntigens)
	Potential FusionNeoAntigens in HLA I - (netMHCpan v4.1 + deepHLApan v1.1)
	Potential FusionNeoAntigens in HLA II - (netMHCIIpan v4.1)
	Fusion Breakpoint 14 AA Peptide Structure - (RoseTTAFold)
	Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D - (Glide)
	Vaccine Design for the FusionNeoAntigens (RNA/protein sequences)
	Potential target of CAR-T therapy development
	Information on the samples that have these potential fusion neoantigens
	Fusion Protein Targeting Drugs - (Manual Curation)
	Fusion Protein Related diseases - (Manual Curation)