FusionNeoAntigen Logo

Home

Download

Statistics

Examples

Help

Contact

Terms of Use
Center for Computational Systems Medicine
leaf

Fusion Gene and Fusion Protein Summary

leaf

Fusion Amino Acid Sequences (multiple BPs and multiple gene isoforms)

leaf

Fusion Protein Breakpoint Sequences - (for the Screening of the FusionNeoAntigens)

leaf

Potential FusionNeoAntigens in HLA I - (netMHCpan v4.1 + deepHLApan v1.1)

leaf

Potential FusionNeoAntigens in HLA II - (netMHCIIpan v4.1)

leaf

Fusion Breakpoint 14 AA Peptide Structure - (RoseTTAFold)

leaf

Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D - (Glide)

leaf

Vaccine Design for the FusionNeoAntigens (RNA/protein sequences)

leaf

Potential target of CAR-T therapy development

leaf

Information on the samples that have these potential fusion neoantigens

leaf

Fusion Protein Targeting Drugs - (Manual Curation)

leaf

Fusion Protein Related diseases - (Manual Curation)

Fusion Protein:ROCK2-MEIS1

Fusion Gene and Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: ROCK2-MEIS1
FusionPDB ID: 75331
FusionGDB2.0 ID: 75331
HgeneTgene
Gene symbol

ROCK2

MEIS1

Gene ID

9475

4211

Gene nameRho associated coiled-coil containing protein kinase 2Meis homeobox 1
SynonymsROCK-II-
Cytomap

2p25.1

2p14

Type of geneprotein-codingprotein-coding
Descriptionrho-associated protein kinase 2p164 ROCK-2rho-associated, coiled-coil-containing protein kinase IIhomeobox protein Meis1Meis1, myeloid ecotropic viral integration site 1 homologWUGSC:H_NH0444B04.1leukemogenic homolog protein
Modification date2020032920200313
UniProtAcc.

O00470

Main function of 5'-partner protein: FUNCTION: Acts as a transcriptional regulator of PAX6. Acts as a transcriptional activator of PF4 in complex with PBX1 or PBX2. Required for hematopoiesis, megakaryocyte lineage development and vascular patterning. May function as a cofactor for HOXA7 and HOXA9 in the induction of myeloid leukemias. {ECO:0000269|PubMed:12609849}.
Ensembl transtripts involved in fusion geneENST idsENST00000315872, ENST00000401753, 
ENST00000462366, 		ENST00000409517, 
ENST00000272369, ENST00000398506, 
ENST00000407092, ENST00000444274, 
ENST00000488550, ENST00000495021, 
ENST00000560281, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score16 X 11 X 9=158411 X 10 X 4=440
# samples 1713
** MAII scorelog2(17/1584*10)=-3.21996568394191
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(13/440*10)=-1.7589919004962
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Fusion gene context

PubMed: ROCK2 [Title/Abstract] AND MEIS1 [Title/Abstract] AND fusion [Title/Abstract]

Fusion neoantigen context

PubMed: ROCK2 [Title/Abstract] AND MEIS1 [Title/Abstract] AND neoantigen [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)ROCK2(11484122)-MEIS1(66775075), # samples:2
Anticipated loss of major functional domain due to fusion event.ROCK2-MEIS1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ROCK2-MEIS1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ROCK2-MEIS1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ROCK2-MEIS1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneROCK2

GO:0006468

protein phosphorylation

18559669



check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:11484122/chr2:66775075)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonRetention analysis results of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features, are available here.

check buttonFusion gene breakpoints across ROCK2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across MEIS1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


Top

Fusion Amino Acid Sequences


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000315872ROCK2chr211484122-ENST00000560281MEIS1chr266775075+1751590449814121
ENST00000315872ROCK2chr211484122-ENST00000407092MEIS1chr266775075+23295904491099216
ENST00000315872ROCK2chr211484122-ENST00000272369MEIS1chr266775075+3536590859386157
ENST00000315872ROCK2chr211484122-ENST00000488550MEIS1chr266775075+451459031633588141
ENST00000315872ROCK2chr211484122-ENST00000398506MEIS1chr266775075+20295904491099216
ENST00000315872ROCK2chr211484122-ENST00000444274MEIS1chr266775075+14295904491099216
ENST00000315872ROCK2chr211484122-ENST00000495021MEIS1chr266775075+15035905150172
ENST00000315872ROCK2chr211484121-ENST00000560281MEIS1chr266775074+1751590449814121
ENST00000315872ROCK2chr211484121-ENST00000407092MEIS1chr266775074+23295904491099216
ENST00000315872ROCK2chr211484121-ENST00000272369MEIS1chr266775074+3536590859386157
ENST00000315872ROCK2chr211484121-ENST00000488550MEIS1chr266775074+451459031633588141
ENST00000315872ROCK2chr211484121-ENST00000398506MEIS1chr266775074+20295904491099216
ENST00000315872ROCK2chr211484121-ENST00000444274MEIS1chr266775074+14295904491099216
ENST00000315872ROCK2chr211484121-ENST00000495021MEIS1chr266775074+15035905150172

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000315872ENST00000560281ROCK2chr211484122-MEIS1chr266775075+0.30923970.69076025
ENST00000315872ENST00000407092ROCK2chr211484122-MEIS1chr266775075+0.0102316150.9897684
ENST00000315872ENST00000272369ROCK2chr211484122-MEIS1chr266775075+0.0182511680.9817488
ENST00000315872ENST00000488550ROCK2chr211484122-MEIS1chr266775075+0.122936650.8770634
ENST00000315872ENST00000398506ROCK2chr211484122-MEIS1chr266775075+0.0101905440.9898094
ENST00000315872ENST00000444274ROCK2chr211484122-MEIS1chr266775075+0.0199531340.9800468
ENST00000315872ENST00000495021ROCK2chr211484122-MEIS1chr266775075+0.0308211260.9691789
ENST00000315872ENST00000560281ROCK2chr211484121-MEIS1chr266775074+0.30923970.69076025
ENST00000315872ENST00000407092ROCK2chr211484121-MEIS1chr266775074+0.0102316150.9897684
ENST00000315872ENST00000272369ROCK2chr211484121-MEIS1chr266775074+0.0182511680.9817488
ENST00000315872ENST00000488550ROCK2chr211484121-MEIS1chr266775074+0.122936650.8770634
ENST00000315872ENST00000398506ROCK2chr211484121-MEIS1chr266775074+0.0101905440.9898094
ENST00000315872ENST00000444274ROCK2chr211484121-MEIS1chr266775074+0.0199531340.9800468
ENST00000315872ENST00000495021ROCK2chr211484121-MEIS1chr266775074+0.0308211260.9691789

check button Predicted full-length fusion amino acid sequences. For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among all the predicted ones.

Get the fusion protein sequences from here.

Fusion protein sequence information is available in the fasta format.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

Top

Fusion Protein Breakpoint Sequences for ROCK2-MEIS1

check button +/-13 AA sequence from the breakpoints of the fusion protein sequences.
HgeneHchrHbpTgeneTchrTbpLength(fusion protein)BP in fusion proteinPeptide
ROCK2chr211484121MEIS1chr26677507459041KLEALIRDPRSPINVESLLHPYPSEE
ROCK2chr211484122MEIS1chr26677507559041KLEALIRDPRSPINVESLLHPYPSEE

Top

Potential FusionNeoAntigen Information of ROCK2-MEIS1 in HLA I

check button Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.

check button Potential FusionNeoAntigen Information
* We used NetMHCpan v4.1 (%rank<0.5) and deepHLApan v1.1 (immunogenic score>0.5)
Fusion geneHchrHbpTgeneTchrTbpHLA IFusionNeoAntigen peptideBinding scoreImmunogenic scoreNeoantigen start (at BP 13)Neoantigen end (at BP 13)

Top

Potential FusionNeoAntigen Information of ROCK2-MEIS1 in HLA II

check button Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.
ROCK2-MEIS1_11484121_66775074.msa

check button Potential FusionNeoAntigen Information
* We used NetMHCIIpan v4.1 (%rank<0.5).
Fusion geneHchrHbpTgeneTchrTbpHLA IIFusionNeoAntigen peptideNeoantigen start (at BP 13)Neoantigen end (at BP 13)
ROCK2-MEIS1chr211484121chr266775074590DRB1-0301LEALIRDPRSPINVE116
ROCK2-MEIS1chr211484121chr266775074590DRB1-0301KLEALIRDPRSPINV015
ROCK2-MEIS1chr211484121chr266775074590DRB1-0301EALIRDPRSPINVES217
ROCK2-MEIS1chr211484121chr266775074590DRB1-0303LEALIRDPRSPINVE116
ROCK2-MEIS1chr211484121chr266775074590DRB1-0303KLEALIRDPRSPINV015
ROCK2-MEIS1chr211484121chr266775074590DRB1-0303EALIRDPRSPINVES217
ROCK2-MEIS1chr211484121chr266775074590DRB1-0305LEALIRDPRSPINVE116
ROCK2-MEIS1chr211484121chr266775074590DRB1-0305KLEALIRDPRSPINV015
ROCK2-MEIS1chr211484121chr266775074590DRB1-0305EALIRDPRSPINVES217
ROCK2-MEIS1chr211484121chr266775074590DRB1-0307LEALIRDPRSPINVE116
ROCK2-MEIS1chr211484121chr266775074590DRB1-0307KLEALIRDPRSPINV015
ROCK2-MEIS1chr211484121chr266775074590DRB1-0307EALIRDPRSPINVES217
ROCK2-MEIS1chr211484121chr266775074590DRB1-0310LEALIRDPRSPINVE116
ROCK2-MEIS1chr211484121chr266775074590DRB1-0310KLEALIRDPRSPINV015
ROCK2-MEIS1chr211484121chr266775074590DRB1-0310EALIRDPRSPINVES217
ROCK2-MEIS1chr211484121chr266775074590DRB1-0313LEALIRDPRSPINVE116
ROCK2-MEIS1chr211484121chr266775074590DRB1-0313KLEALIRDPRSPINV015
ROCK2-MEIS1chr211484121chr266775074590DRB1-0313EALIRDPRSPINVES217
ROCK2-MEIS1chr211484121chr266775074590DRB1-0315LEALIRDPRSPINVE116
ROCK2-MEIS1chr211484121chr266775074590DRB1-0315KLEALIRDPRSPINV015
ROCK2-MEIS1chr211484121chr266775074590DRB1-0315EALIRDPRSPINVES217
ROCK2-MEIS1chr211484121chr266775074590DRB1-0318LEALIRDPRSPINVE116
ROCK2-MEIS1chr211484121chr266775074590DRB1-0318KLEALIRDPRSPINV015
ROCK2-MEIS1chr211484121chr266775074590DRB1-0318EALIRDPRSPINVES217
ROCK2-MEIS1chr211484121chr266775074590DRB1-0320LEALIRDPRSPINVE116
ROCK2-MEIS1chr211484121chr266775074590DRB1-0320KLEALIRDPRSPINV015
ROCK2-MEIS1chr211484121chr266775074590DRB1-0320EALIRDPRSPINVES217
ROCK2-MEIS1chr211484121chr266775074590DRB1-0322LEALIRDPRSPINVE116
ROCK2-MEIS1chr211484121chr266775074590DRB1-0322KLEALIRDPRSPINV015
ROCK2-MEIS1chr211484121chr266775074590DRB1-0322EALIRDPRSPINVES217
ROCK2-MEIS1chr211484121chr266775074590DRB1-0324LEALIRDPRSPINVE116
ROCK2-MEIS1chr211484121chr266775074590DRB1-0324KLEALIRDPRSPINV015
ROCK2-MEIS1chr211484121chr266775074590DRB1-0324EALIRDPRSPINVES217
ROCK2-MEIS1chr211484121chr266775074590DRB1-0326LEALIRDPRSPINVE116
ROCK2-MEIS1chr211484121chr266775074590DRB1-0326KLEALIRDPRSPINV015
ROCK2-MEIS1chr211484121chr266775074590DRB1-0326EALIRDPRSPINVES217
ROCK2-MEIS1chr211484121chr266775074590DRB1-0328LEALIRDPRSPINVE116
ROCK2-MEIS1chr211484121chr266775074590DRB1-0328KLEALIRDPRSPINV015
ROCK2-MEIS1chr211484121chr266775074590DRB1-0328EALIRDPRSPINVES217
ROCK2-MEIS1chr211484121chr266775074590DRB1-0330LEALIRDPRSPINVE116
ROCK2-MEIS1chr211484121chr266775074590DRB1-0330KLEALIRDPRSPINV015
ROCK2-MEIS1chr211484121chr266775074590DRB1-0330EALIRDPRSPINVES217
ROCK2-MEIS1chr211484121chr266775074590DRB1-0332LEALIRDPRSPINVE116
ROCK2-MEIS1chr211484121chr266775074590DRB1-0332KLEALIRDPRSPINV015
ROCK2-MEIS1chr211484121chr266775074590DRB1-0332EALIRDPRSPINVES217
ROCK2-MEIS1chr211484121chr266775074590DRB1-0334LEALIRDPRSPINVE116
ROCK2-MEIS1chr211484121chr266775074590DRB1-0334KLEALIRDPRSPINV015
ROCK2-MEIS1chr211484121chr266775074590DRB1-0334EALIRDPRSPINVES217
ROCK2-MEIS1chr211484121chr266775074590DRB1-0336LEALIRDPRSPINVE116
ROCK2-MEIS1chr211484121chr266775074590DRB1-0336KLEALIRDPRSPINV015
ROCK2-MEIS1chr211484121chr266775074590DRB1-0336EALIRDPRSPINVES217
ROCK2-MEIS1chr211484121chr266775074590DRB1-0338LEALIRDPRSPINVE116
ROCK2-MEIS1chr211484121chr266775074590DRB1-0338KLEALIRDPRSPINV015
ROCK2-MEIS1chr211484121chr266775074590DRB1-0338EALIRDPRSPINVES217
ROCK2-MEIS1chr211484121chr266775074590DRB1-0340LEALIRDPRSPINVE116
ROCK2-MEIS1chr211484121chr266775074590DRB1-0340KLEALIRDPRSPINV015
ROCK2-MEIS1chr211484121chr266775074590DRB1-0340EALIRDPRSPINVES217
ROCK2-MEIS1chr211484121chr266775074590DRB1-0342LEALIRDPRSPINVE116
ROCK2-MEIS1chr211484121chr266775074590DRB1-0342KLEALIRDPRSPINV015
ROCK2-MEIS1chr211484121chr266775074590DRB1-0344LEALIRDPRSPINVE116
ROCK2-MEIS1chr211484121chr266775074590DRB1-0344KLEALIRDPRSPINV015
ROCK2-MEIS1chr211484121chr266775074590DRB1-0344EALIRDPRSPINVES217
ROCK2-MEIS1chr211484121chr266775074590DRB1-0346LEALIRDPRSPINVE116
ROCK2-MEIS1chr211484121chr266775074590DRB1-0346KLEALIRDPRSPINV015
ROCK2-MEIS1chr211484121chr266775074590DRB1-0346EALIRDPRSPINVES217
ROCK2-MEIS1chr211484121chr266775074590DRB1-0348LEALIRDPRSPINVE116
ROCK2-MEIS1chr211484121chr266775074590DRB1-0348KLEALIRDPRSPINV015
ROCK2-MEIS1chr211484121chr266775074590DRB1-0348EALIRDPRSPINVES217
ROCK2-MEIS1chr211484121chr266775074590DRB1-0350LEALIRDPRSPINVE116
ROCK2-MEIS1chr211484121chr266775074590DRB1-0350KLEALIRDPRSPINV015
ROCK2-MEIS1chr211484121chr266775074590DRB1-0350EALIRDPRSPINVES217
ROCK2-MEIS1chr211484121chr266775074590DRB1-0352LEALIRDPRSPINVE116
ROCK2-MEIS1chr211484121chr266775074590DRB1-0352KLEALIRDPRSPINV015
ROCK2-MEIS1chr211484121chr266775074590DRB1-0352EALIRDPRSPINVES217
ROCK2-MEIS1chr211484121chr266775074590DRB1-0354LEALIRDPRSPINVE116
ROCK2-MEIS1chr211484121chr266775074590DRB1-0354KLEALIRDPRSPINV015
ROCK2-MEIS1chr211484121chr266775074590DRB1-0354EALIRDPRSPINVES217
ROCK2-MEIS1chr211484121chr266775074590DRB1-1107LEALIRDPRSPINVE116
ROCK2-MEIS1chr211484121chr266775074590DRB1-1107KLEALIRDPRSPINV015
ROCK2-MEIS1chr211484121chr266775074590DRB1-1107EALIRDPRSPINVES217
ROCK2-MEIS1chr211484121chr266775074590DRB1-1179LEALIRDPRSPINVE116
ROCK2-MEIS1chr211484121chr266775074590DRB1-1333LEALIRDPRSPINVE116
ROCK2-MEIS1chr211484121chr266775074590DRB1-1394LEALIRDPRSPINVE116
ROCK2-MEIS1chr211484121chr266775074590DRB1-1394KLEALIRDPRSPINV015
ROCK2-MEIS1chr211484121chr266775074590DRB1-1419LEALIRDPRSPINVE116
ROCK2-MEIS1chr211484121chr266775074590DRB1-1419KLEALIRDPRSPINV015
ROCK2-MEIS1chr211484121chr266775074590DRB1-1421LEALIRDPRSPINVE116
ROCK2-MEIS1chr211484121chr266775074590DRB1-1421KLEALIRDPRSPINV015
ROCK2-MEIS1chr211484121chr266775074590DRB1-1438LEALIRDPRSPINVE116
ROCK2-MEIS1chr211484121chr266775074590DRB1-1438KLEALIRDPRSPINV015
ROCK2-MEIS1chr211484121chr266775074590DRB1-1449LEALIRDPRSPINVE116
ROCK2-MEIS1chr211484121chr266775074590DRB1-1450LEALIRDPRSPINVE116
ROCK2-MEIS1chr211484121chr266775074590DRB1-1476LEALIRDPRSPINVE116
ROCK2-MEIS1chr211484121chr266775074590DRB1-1476KLEALIRDPRSPINV015
ROCK2-MEIS1chr211484121chr266775074590DRB1-1476EALIRDPRSPINVES217
ROCK2-MEIS1chr211484121chr266775074590DRB1-1479LEALIRDPRSPINVE116
ROCK2-MEIS1chr211484121chr266775074590DRB1-1479KLEALIRDPRSPINV015
ROCK2-MEIS1chr211484121chr266775074590DRB1-1479EALIRDPRSPINVES217
ROCK2-MEIS1chr211484121chr266775074590DRB1-1482LEALIRDPRSPINVE116
ROCK2-MEIS1chr211484121chr266775074590DRB1-1482KLEALIRDPRSPINV015
ROCK2-MEIS1chr211484121chr266775074590DRB1-1482EALIRDPRSPINVES217
ROCK2-MEIS1chr211484121chr266775074590DRB1-1495LEALIRDPRSPINVE116
ROCK2-MEIS1chr211484121chr266775074590DRB3-0114LEALIRDPRSPINVE116
ROCK2-MEIS1chr211484121chr266775074590DRB3-0114KLEALIRDPRSPINV015
ROCK2-MEIS1chr211484121chr266775074590DRB3-0114EALIRDPRSPINVES217

Top

Fusion breakpoint peptide structures of ROCK2-MEIS1

check button3D structures of the fusion breakpoint peptide of 14AA sequence that have potential fusion neoantigens
* The minimum length of the amino acid sequence in RoseTTAFold is 14AA. Here, we predicted the 14AA fusion protein breakpoint sequence not the fusion neoantigen peptide, which is shorter than 14 AA.

Top

Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D of ROCK2-MEIS1

check buttonVirtual screening between 25 HLAs (from PDB) and FusionNeoAntigens
* We used Glide to predict the interaction between HLAs and neoantigens.
HLA allelePDB IDFile nameBPseqDocking scoreGlide score

Top

Vaccine Design for the FusionNeoAntigens of ROCK2-MEIS1

check button mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-Is.
Fusion geneHchrHbpTchrTbpStart in +/-13AAEnd in +/-13AAFusionNeoAntigen peptide sequenceFusionNeoAntigen RNA sequence

check button mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-IIs.
Fusion geneHchrHbpTchrTbpStart in +/-13AAEnd in +/-13AAFusionNeoAntigen peptideFusionNEoAntigen RNA sequence
ROCK2-MEIS1chr211484121chr266775074015KLEALIRDPRSPINVCGAGACCCTCGCTCCCCCATCAACGTGGAGAGCTTGCTGCACCCT
ROCK2-MEIS1chr211484121chr266775074116LEALIRDPRSPINVEGACCCTCGCTCCCCCATCAACGTGGAGAGCTTGCTGCACCCTTAC
ROCK2-MEIS1chr211484121chr266775074217EALIRDPRSPINVESCCTCGCTCCCCCATCAACGTGGAGAGCTTGCTGCACCCTTACCCT

Top

Information of the samples that have these potential fusion neoantigens of ROCK2-MEIS1

check button These samples were reported as having these fusion breakpoints. For individual breakpoints, we checked the open reading frames considering multiple gene isoforms and chose the in-frame fusion genes only. Then, we made fusion protein sequences and predicted the fusion neoantigens. These fusion-positive samples may have these potential fusion neoantigens.
Cancer typeFusion geneHchrHbpHenstTchrTbpTenstSample

Top

Potential target of CAR-T therapy development for ROCK2-MEIS1

check button Predicted 3D structure. We used RoseTTAFold.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, to provide the retention of the transmembrane domain, we only show the protein feature retention information of those transmembrane features


* Minus value of BPloci means that the break point is located before the CDS.
- In-frame and retained 'Transmembrane'.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

check button Subcellular localization prediction of the transmembrane domain retained fusion proteins
* We used DeepLoc 1.0. The order of the X-axis of the barplot is as follows: Entry_ID, Localization, Type, Nucleus, Cytoplasm, Extracellular, Mitochondrion, Cell_membrane, Endoplasmic_reticulum, Plastid, Golgi.apparatus, Lysosome.Vacuole, Peroxisome. Y-axis is the output score of DeepLoc. Clicking the image will open a new tab with a large image.
HgeneHchrHbpHenstTgeneTchrTbpTenstDeepLoc result

Top

Related Drugs to ROCK2-MEIS1

check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

Top

Related Diseases to ROCK2-MEIS1

check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource