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Fusion Protein:ATP11A-TUBGCP3

Fusion Gene and Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: ATP11A-TUBGCP3
	FusionPDB ID: 7721
	FusionGDB2.0 ID: 7721
		Hgene	Tgene
	Gene symbol	ATP11A	TUBGCP3
	Gene ID	23250	10426
	Gene name	ATPase phospholipid transporting 11A	tubulin gamma complex associated protein 3
	Synonyms	ATPIH\|ATPIS	104p\|ALP6\|GCP3\|Grip104\|SPBC98\|Spc98\|Spc98p
	Cytomap	13q34	13q34
	Type of gene	protein-coding	protein-coding
	Description	probable phospholipid-transporting ATPase IHATPase, class VI, type 11AP4-ATPase flippase complex alpha subunit ATP11Aphospholipid-translocating ATPasepotential phospholipid-transporting ATPase IH	gamma-tubulin complex component 3gamma-ring complex protein 104 kDaspindle pole body protein Spc98 homolog
	Modification date	20200313	20200313
	UniProtAcc	Q6ZP68 Main function of 5'-partner protein:	.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000283558, ENST00000375630, ENST00000375645, ENST00000487903, ENST00000419448,	ENST00000462580, ENST00000261965, ENST00000375669,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	20 X 11 X 16=3520	5 X 5 X 2=50
	# samples	31	5
	** MAII score	log2(31/3520*10)=-3.50523530825042 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(5/50*10)=0
Fusion gene context	PubMed: ATP11A [Title/Abstract] AND TUBGCP3 [Title/Abstract] AND fusion [Title/Abstract]
Fusion neoantigen context	PubMed: ATP11A [Title/Abstract] AND TUBGCP3 [Title/Abstract] AND neoantigen [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	ATP11A(113490565)-TUBGCP3(113209319), # samples:2 TUBGCP3(113158346)-ATP11A(113490492), # samples:2
Anticipated loss of major functional domain due to fusion event.	ATP11A-TUBGCP3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ATP11A-TUBGCP3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. TUBGCP3-ATP11A seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. TUBGCP3-ATP11A seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF. TUBGCP3-ATP11A seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr13:113490565/chr13:113209319)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Retention analysis results of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features, are available here.

Fusion gene breakpoints across ATP11A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across TUBGCP3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Amino Acid Sequences

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000283558	ATP11A	chr13	113490565	+	ENST00000261965	TUBGCP3	chr13	113209319	-	4778	1793	55	3795	1246
ENST00000283558	ATP11A	chr13	113490565	+	ENST00000375669	TUBGCP3	chr13	113209319	-	3648	1793	55	3546	1163
ENST00000375630	ATP11A	chr13	113490565	+	ENST00000261965	TUBGCP3	chr13	113209319	-	4778	1793	55	3795	1246
ENST00000375630	ATP11A	chr13	113490565	+	ENST00000375669	TUBGCP3	chr13	113209319	-	3648	1793	55	3546	1163
ENST00000487903	ATP11A	chr13	113490565	+	ENST00000261965	TUBGCP3	chr13	113209319	-	4778	1793	55	3795	1246
ENST00000487903	ATP11A	chr13	113490565	+	ENST00000375669	TUBGCP3	chr13	113209319	-	3648	1793	55	3546	1163
ENST00000375645	ATP11A	chr13	113490565	+	ENST00000261965	TUBGCP3	chr13	113209319	-	4778	1793	55	3795	1246
ENST00000375645	ATP11A	chr13	113490565	+	ENST00000375669	TUBGCP3	chr13	113209319	-	3648	1793	55	3546	1163

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000283558	ENST00000261965	ATP11A	chr13	113490565	+	TUBGCP3	chr13	113209319	-	0.000104098	0.99989593
ENST00000283558	ENST00000375669	ATP11A	chr13	113490565	+	TUBGCP3	chr13	113209319	-	0.000274543	0.9997254
ENST00000375630	ENST00000261965	ATP11A	chr13	113490565	+	TUBGCP3	chr13	113209319	-	0.000104098	0.99989593
ENST00000375630	ENST00000375669	ATP11A	chr13	113490565	+	TUBGCP3	chr13	113209319	-	0.000274543	0.9997254
ENST00000487903	ENST00000261965	ATP11A	chr13	113490565	+	TUBGCP3	chr13	113209319	-	0.000104098	0.99989593
ENST00000487903	ENST00000375669	ATP11A	chr13	113490565	+	TUBGCP3	chr13	113209319	-	0.000274543	0.9997254
ENST00000375645	ENST00000261965	ATP11A	chr13	113490565	+	TUBGCP3	chr13	113209319	-	0.000104098	0.99989593
ENST00000375645	ENST00000375669	ATP11A	chr13	113490565	+	TUBGCP3	chr13	113209319	-	0.000274543	0.9997254

Predicted full-length fusion amino acid sequences. For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among all the predicted ones.

Get the fusion protein sequences from here.

Fusion protein sequence information is available in the fasta format.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

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Fusion Protein Breakpoint Sequences for ATP11A-TUBGCP3

+/-13 AA sequence from the breakpoints of the fusion protein sequences.

Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	Length(fusion protein)	BP in fusion protein	Peptide
ATP11A	chr13	113490565	TUBGCP3	chr13	113209319	1793	579	VRRRMSVIVKSATGTMEITEAALVRD

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Potential FusionNeoAntigen Information of ATP11A-TUBGCP3 in HLA I

Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.

ATP11A-TUBGCP3_113490565_113209319.msa

Potential FusionNeoAntigen Information
* We used NetMHCpan v4.1 (%rank<0.5) and deepHLApan v1.1 (immunogenic score>0.5)

Fusion gene	Hchr	Hbp	Tgene	Tchr	Tbp	HLA I	FusionNeoAntigen peptide	Binding score	Immunogenic score	Neoantigen start (at BP 13)	Neoantigen end (at BP 13)
ATP11A-TUBGCP3	chr13	113490565	chr13	113209319	1793	HLA-B15:16	KSATGTMEI	0.994	0.6451	9	18
ATP11A-TUBGCP3	chr13	113490565	chr13	113209319	1793	HLA-B15:02	IVKSATGTM	0.9669	0.766	7	16
ATP11A-TUBGCP3	chr13	113490565	chr13	113209319	1793	HLA-C15:04	KSATGTMEI	0.9994	0.8219	9	18
ATP11A-TUBGCP3	chr13	113490565	chr13	113209319	1793	HLA-C15:06	KSATGTMEI	0.999	0.7415	9	18
ATP11A-TUBGCP3	chr13	113490565	chr13	113209319	1793	HLA-C12:12	IVKSATGTM	0.9636	0.8586	7	16
ATP11A-TUBGCP3	chr13	113490565	chr13	113209319	1793	HLA-B15:04	IVKSATGTM	0.9333	0.5182	7	16
ATP11A-TUBGCP3	chr13	113490565	chr13	113209319	1793	HLA-C06:03	KSATGTMEI	0.9073	0.9818	9	18
ATP11A-TUBGCP3	chr13	113490565	chr13	113209319	1793	HLA-C02:06	KSATGTMEI	0.6759	0.9133	9	18
ATP11A-TUBGCP3	chr13	113490565	chr13	113209319	1793	HLA-C15:09	KSATGTMEI	0.9994	0.8219	9	18
ATP11A-TUBGCP3	chr13	113490565	chr13	113209319	1793	HLA-C15:02	KSATGTMEI	0.9994	0.5901	9	18
ATP11A-TUBGCP3	chr13	113490565	chr13	113209319	1793	HLA-C15:05	KSATGTMEI	0.999	0.6553	9	18
ATP11A-TUBGCP3	chr13	113490565	chr13	113209319	1793	HLA-C12:02	IVKSATGTM	0.977	0.8956	7	16
ATP11A-TUBGCP3	chr13	113490565	chr13	113209319	1793	HLA-C16:02	KSATGTMEI	0.976	0.9833	9	18
ATP11A-TUBGCP3	chr13	113490565	chr13	113209319	1793	HLA-C03:02	IVKSATGTM	0.9434	0.8145	7	16
ATP11A-TUBGCP3	chr13	113490565	chr13	113209319	1793	HLA-B15:73	IVKSATGTM	0.8375	0.6804	7	16
ATP11A-TUBGCP3	chr13	113490565	chr13	113209319	1793	HLA-B15:30	IVKSATGTM	0.7833	0.514	7	16
ATP11A-TUBGCP3	chr13	113490565	chr13	113209319	1793	HLA-C17:01	KSATGTMEI	0.301	0.8215	9	18

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Potential FusionNeoAntigen Information of ATP11A-TUBGCP3 in HLA II

ATP11A-TUBGCP3_113490565_113209319.msa

Potential FusionNeoAntigen Information
* We used NetMHCIIpan v4.1 (%rank<0.5).

Fusion gene	Hchr	Hbp	Tgene	Tchr	Tbp	HLA II	FusionNeoAntigen peptide	Neoantigen start (at BP 13)	Neoantigen end (at BP 13)
ATP11A-TUBGCP3	chr13	113490565	chr13	113209319	1793	DRB1-0701	ATGTMEITEAALVRD	11	26
ATP11A-TUBGCP3	chr13	113490565	chr13	113209319	1793	DRB1-0701	SATGTMEITEAALVR	10	25
ATP11A-TUBGCP3	chr13	113490565	chr13	113209319	1793	DRB1-0703	ATGTMEITEAALVRD	11	26
ATP11A-TUBGCP3	chr13	113490565	chr13	113209319	1793	DRB1-0703	SATGTMEITEAALVR	10	25
ATP11A-TUBGCP3	chr13	113490565	chr13	113209319	1793	DRB1-0704	ATGTMEITEAALVRD	11	26
ATP11A-TUBGCP3	chr13	113490565	chr13	113209319	1793	DRB1-0704	SATGTMEITEAALVR	10	25
ATP11A-TUBGCP3	chr13	113490565	chr13	113209319	1793	DRB1-0705	ATGTMEITEAALVRD	11	26
ATP11A-TUBGCP3	chr13	113490565	chr13	113209319	1793	DRB1-0705	SATGTMEITEAALVR	10	25
ATP11A-TUBGCP3	chr13	113490565	chr13	113209319	1793	DRB1-0706	ATGTMEITEAALVRD	11	26
ATP11A-TUBGCP3	chr13	113490565	chr13	113209319	1793	DRB1-0706	SATGTMEITEAALVR	10	25
ATP11A-TUBGCP3	chr13	113490565	chr13	113209319	1793	DRB1-0707	ATGTMEITEAALVRD	11	26
ATP11A-TUBGCP3	chr13	113490565	chr13	113209319	1793	DRB1-0707	SATGTMEITEAALVR	10	25
ATP11A-TUBGCP3	chr13	113490565	chr13	113209319	1793	DRB1-0708	ATGTMEITEAALVRD	11	26
ATP11A-TUBGCP3	chr13	113490565	chr13	113209319	1793	DRB1-0708	SATGTMEITEAALVR	10	25
ATP11A-TUBGCP3	chr13	113490565	chr13	113209319	1793	DRB1-0709	ATGTMEITEAALVRD	11	26
ATP11A-TUBGCP3	chr13	113490565	chr13	113209319	1793	DRB1-0709	SATGTMEITEAALVR	10	25
ATP11A-TUBGCP3	chr13	113490565	chr13	113209319	1793	DRB1-0711	ATGTMEITEAALVRD	11	26
ATP11A-TUBGCP3	chr13	113490565	chr13	113209319	1793	DRB1-0711	SATGTMEITEAALVR	10	25
ATP11A-TUBGCP3	chr13	113490565	chr13	113209319	1793	DRB1-0712	ATGTMEITEAALVRD	11	26
ATP11A-TUBGCP3	chr13	113490565	chr13	113209319	1793	DRB1-0712	SATGTMEITEAALVR	10	25
ATP11A-TUBGCP3	chr13	113490565	chr13	113209319	1793	DRB1-0713	ATGTMEITEAALVRD	11	26
ATP11A-TUBGCP3	chr13	113490565	chr13	113209319	1793	DRB1-0713	SATGTMEITEAALVR	10	25
ATP11A-TUBGCP3	chr13	113490565	chr13	113209319	1793	DRB1-0714	ATGTMEITEAALVRD	11	26
ATP11A-TUBGCP3	chr13	113490565	chr13	113209319	1793	DRB1-0714	SATGTMEITEAALVR	10	25
ATP11A-TUBGCP3	chr13	113490565	chr13	113209319	1793	DRB1-0715	ATGTMEITEAALVRD	11	26
ATP11A-TUBGCP3	chr13	113490565	chr13	113209319	1793	DRB1-0715	SATGTMEITEAALVR	10	25
ATP11A-TUBGCP3	chr13	113490565	chr13	113209319	1793	DRB1-0716	ATGTMEITEAALVRD	11	26
ATP11A-TUBGCP3	chr13	113490565	chr13	113209319	1793	DRB1-0716	SATGTMEITEAALVR	10	25
ATP11A-TUBGCP3	chr13	113490565	chr13	113209319	1793	DRB1-0717	ATGTMEITEAALVRD	11	26
ATP11A-TUBGCP3	chr13	113490565	chr13	113209319	1793	DRB1-0717	SATGTMEITEAALVR	10	25
ATP11A-TUBGCP3	chr13	113490565	chr13	113209319	1793	DRB1-0719	ATGTMEITEAALVRD	11	26
ATP11A-TUBGCP3	chr13	113490565	chr13	113209319	1793	DRB1-0719	SATGTMEITEAALVR	10	25
ATP11A-TUBGCP3	chr13	113490565	chr13	113209319	1793	DRB1-0904	ATGTMEITEAALVRD	11	26
ATP11A-TUBGCP3	chr13	113490565	chr13	113209319	1793	DRB1-0906	ATGTMEITEAALVRD	11	26
ATP11A-TUBGCP3	chr13	113490565	chr13	113209319	1793	DRB1-0907	ATGTMEITEAALVRD	11	26
ATP11A-TUBGCP3	chr13	113490565	chr13	113209319	1793	DRB1-1439	ATGTMEITEAALVRD	11	26
ATP11A-TUBGCP3	chr13	113490565	chr13	113209319	1793	DRB3-0301	ATGTMEITEAALVRD	11	26

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Fusion breakpoint peptide structures of ATP11A-TUBGCP3

3D structures of the fusion breakpoint peptide of 14AA sequence that have potential fusion neoantigens
* The minimum length of the amino acid sequence in RoseTTAFold is 14AA. Here, we predicted the 14AA fusion protein breakpoint sequence not the fusion neoantigen peptide, which is shorter than 14 AA.

File name	BPseq	Hgene	Tgene	Hchr	Hbp	Tchr	Tbp	AAlen
10026	VIVKSATGTMEITE	ATP11A	TUBGCP3	chr13	113490565	chr13	113209319	1793

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Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D of ATP11A-TUBGCP3

Virtual screening between 25 HLAs (from PDB) and FusionNeoAntigens
* We used Glide to predict the interaction between HLAs and neoantigens.

HLA allele	PDB ID	File name	BPseq	Docking score	Glide score
HLA-B14:02	3BVN	10026	VIVKSATGTMEITE	-5.50071	-6.53601
HLA-B14:02	3BVN	10026	VIVKSATGTMEITE	-5.44997	-5.56337
HLA-B52:01	3W39	10026	VIVKSATGTMEITE	-6.87928	-6.99268
HLA-B52:01	3W39	10026	VIVKSATGTMEITE	-3.95744	-4.99274
HLA-A24:02	5HGA	10026	VIVKSATGTMEITE	-7.30598	-7.41938
HLA-A24:02	5HGA	10026	VIVKSATGTMEITE	-5.09366	-6.12896
HLA-B44:05	3DX8	10026	VIVKSATGTMEITE	-5.64505	-5.75845
HLA-B44:05	3DX8	10026	VIVKSATGTMEITE	-4.1878	-5.2231
HLA-B35:01	1A1N	10026	VIVKSATGTMEITE	-6.8383	-7.8736
HLA-B35:01	1A1N	10026	VIVKSATGTMEITE	-6.50818	-6.62158
HLA-A02:01	6TDR	10026	VIVKSATGTMEITE	-0.0912853	-1.12659

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Vaccine Design for the FusionNeoAntigens of ATP11A-TUBGCP3

mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-Is.

Fusion gene	Hchr	Hbp	Tchr	Tbp	Start in +/-13AA	End in +/-13AA	FusionNeoAntigen peptide sequence	FusionNeoAntigen RNA sequence
ATP11A-TUBGCP3	chr13	113490565	chr13	113209319	7	16	IVKSATGTM	TTGTAAAATCTGCTACAGGTACTATGG
ATP11A-TUBGCP3	chr13	113490565	chr13	113209319	9	18	KSATGTMEI	AATCTGCTACAGGTACTATGGAAATTA

mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-IIs.

Fusion gene	Hchr	Hbp	Tchr	Tbp	Start in +/-13AA	End in +/-13AA	FusionNeoAntigen peptide	FusionNEoAntigen RNA sequence
ATP11A-TUBGCP3	chr13	113490565	chr13	113209319	10	25	SATGTMEITEAALVR	CTGCTACAGGTACTATGGAAATTACAGAAGCAGCTCTGGTAAGGG
ATP11A-TUBGCP3	chr13	113490565	chr13	113209319	11	26	ATGTMEITEAALVRD	CTACAGGTACTATGGAAATTACAGAAGCAGCTCTGGTAAGGGACA

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Information of the samples that have these potential fusion neoantigens of ATP11A-TUBGCP3

These samples were reported as having these fusion breakpoints. For individual breakpoints, we checked the open reading frames considering multiple gene isoforms and chose the in-frame fusion genes only. Then, we made fusion protein sequences and predicted the fusion neoantigens. These fusion-positive samples may have these potential fusion neoantigens.

Cancer type	Fusion gene	Hchr	Hbp	Henst	Tchr	Tbp	Tenst	Sample
BRCA	ATP11A-TUBGCP3	chr13	113490565	ENST00000283558	chr13	113209319	ENST00000261965	TCGA-D8-A143-01A

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Potential target of CAR-T therapy development for ATP11A-TUBGCP3

Predicted 3D structure. We used RoseTTAFold.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, to provide the retention of the transmembrane domain, we only show the protein feature retention information of those transmembrane features

* Minus value of BPloci means that the break point is located before the CDS.

- In-frame and retained 'Transmembrane'.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ATP11A

chr13:113490565

chr13:113209319

ENST00000283558

297_318

568

1135.0

Transmembrane

Helical

Hgene

ATP11A

chr13:113490565

chr13:113209319

ENST00000283558

350_372

568

1135.0

Transmembrane

Helical

Hgene

ATP11A

chr13:113490565

chr13:113209319

ENST00000283558

62_82

568

1135.0

Transmembrane

Helical

Hgene

ATP11A

chr13:113490565

chr13:113209319

ENST00000283558

89_110

568

1135.0

Transmembrane

Helical

Hgene

ATP11A

chr13:113490565

chr13:113209319

ENST00000375645

297_318

568

2857.0

Transmembrane

Helical

Hgene

ATP11A

chr13:113490565

chr13:113209319

ENST00000375645

350_372

568

2857.0

Transmembrane

Helical

Hgene

ATP11A

chr13:113490565

chr13:113209319

ENST00000375645

62_82

568

2857.0

Transmembrane

Helical

Hgene

ATP11A

chr13:113490565

chr13:113209319

ENST00000375645

89_110

568

2857.0

Transmembrane

Helical

Hgene

ATP11A

chr13:113490565

chr13:113209319

ENST00000487903

297_318

568

2878.0

Transmembrane

Helical

Hgene

ATP11A

chr13:113490565

chr13:113209319

ENST00000487903

350_372

568

2878.0

Transmembrane

Helical

Hgene

ATP11A

chr13:113490565

chr13:113209319

ENST00000487903

62_82

568

2878.0

Transmembrane

Helical

Hgene

ATP11A

chr13:113490565

chr13:113209319

ENST00000487903

89_110

568

2878.0

Transmembrane

Helical

Subcellular localization prediction of the transmembrane domain retained fusion proteins
* We used DeepLoc 1.0. The order of the X-axis of the barplot is as follows: Entry_ID, Localization, Type, Nucleus, Cytoplasm, Extracellular, Mitochondrion, Cell_membrane, Endoplasmic_reticulum, Plastid, Golgi.apparatus, Lysosome.Vacuole, Peroxisome. Y-axis is the output score of DeepLoc. Clicking the image will open a new tab with a large image.

Hgene

Hchr

Hbp

Henst

Tgene

Tchr

Tbp

Tenst

DeepLoc result

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Related Drugs to ATP11A-TUBGCP3

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to ATP11A-TUBGCP3

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source

	Fusion Gene and Fusion Protein Summary
	Fusion Amino Acid Sequences (multiple BPs and multiple gene isoforms)
	Fusion Protein Breakpoint Sequences - (for the Screening of the FusionNeoAntigens)
	Potential FusionNeoAntigens in HLA I - (netMHCpan v4.1 + deepHLApan v1.1)
	Potential FusionNeoAntigens in HLA II - (netMHCIIpan v4.1)
	Fusion Breakpoint 14 AA Peptide Structure - (RoseTTAFold)
	Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D - (Glide)
	Vaccine Design for the FusionNeoAntigens (RNA/protein sequences)
	Potential target of CAR-T therapy development
	Information on the samples that have these potential fusion neoantigens
	Fusion Protein Targeting Drugs - (Manual Curation)
	Fusion Protein Related diseases - (Manual Curation)