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Fusion Protein:ATP1A1-SLC12A1

Fusion Gene and Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: ATP1A1-SLC12A1
	FusionPDB ID: 7790
	FusionGDB2.0 ID: 7790
		Hgene	Tgene
	Gene symbol	ATP1A1	SLC12A1
	Gene ID	480	6557
	Gene name	ATPase Na+/K+ transporting subunit alpha 4	solute carrier family 12 member 1
	Synonyms	ATP1A1\|ATP1AL2	BSC1\|NKCC2
	Cytomap	1q23.2	15q21.1
	Type of gene	protein-coding	protein-coding
	Description	sodium/potassium-transporting ATPase subunit alpha-4ATPase, Na+/K+ transporting, alpha 4 polypeptideATPase, Na+/K+ transporting, alpha polypeptide-like 2Na(+)/K(+) ATPase alpha-4 subunitNa+/K+ ATPase 4Na+/K+ ATPase, alpha-D polypeptideNa,K-ATPase su	solute carrier family 12 member 1NKCC2A variant ANa-K-2Cl cotransporterbumetanide-sensitive sodium-(potassium)-chloride cotransporter 2kidney-specific Na-K-Cl symportersolute carrier family 12 (sodium/potassium/chloride transporter), member 1solute
	Modification date	20200313	20200313
	UniProtAcc	Q5TC04 Main function of 5'-partner protein:	.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000295598, ENST00000369496, ENST00000537345, ENST00000491156,	ENST00000559723, ENST00000330289, ENST00000380993, ENST00000396577, ENST00000558405, ENST00000561031,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	16 X 18 X 7=2016	6 X 7 X 5=210
	# samples	23	7
	** MAII score	log2(23/2016*10)=-3.13178987255554 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(7/210*10)=-1.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Fusion gene context	PubMed: ATP1A1 [Title/Abstract] AND SLC12A1 [Title/Abstract] AND fusion [Title/Abstract]
Fusion neoantigen context	PubMed: ATP1A1 [Title/Abstract] AND SLC12A1 [Title/Abstract] AND neoantigen [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	ATP1A1(116933513)-SLC12A1(48513118), # samples:1
Anticipated loss of major functional domain due to fusion event.	ATP1A1-SLC12A1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ATP1A1-SLC12A1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	ATP1A1	GO:0030317	flagellated sperm motility	12112599
Hgene	ATP1A1	GO:0030641	regulation of cellular pH	12112599

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:116933513/chr15:48513118)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Retention analysis results of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features, are available here.

Fusion gene breakpoints across ATP1A1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across SLC12A1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Amino Acid Sequences

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000295598	ATP1A1	chr1	116933513	+	ENST00000380993	SLC12A1	chr15	48513118	+	5523	1584	237	4331	1364
ENST00000295598	ATP1A1	chr1	116933513	+	ENST00000396577	SLC12A1	chr15	48513118	+	5525	1584	237	4331	1364
ENST00000295598	ATP1A1	chr1	116933513	+	ENST00000330289	SLC12A1	chr15	48513118	+	2610	1584	237	2324	695
ENST00000295598	ATP1A1	chr1	116933513	+	ENST00000558405	SLC12A1	chr15	48513118	+	4444	1584	237	4331	1364
ENST00000295598	ATP1A1	chr1	116933513	+	ENST00000561031	SLC12A1	chr15	48513118	+	1767	1584	237	1685	482
ENST00000537345	ATP1A1	chr1	116933513	+	ENST00000380993	SLC12A1	chr15	48513118	+	5634	1695	318	4442	1374
ENST00000537345	ATP1A1	chr1	116933513	+	ENST00000396577	SLC12A1	chr15	48513118	+	5636	1695	318	4442	1374
ENST00000537345	ATP1A1	chr1	116933513	+	ENST00000330289	SLC12A1	chr15	48513118	+	2721	1695	318	2435	705
ENST00000537345	ATP1A1	chr1	116933513	+	ENST00000558405	SLC12A1	chr15	48513118	+	4555	1695	318	4442	1374
ENST00000537345	ATP1A1	chr1	116933513	+	ENST00000561031	SLC12A1	chr15	48513118	+	1878	1695	318	1796	492
ENST00000369496	ATP1A1	chr1	116933513	+	ENST00000380993	SLC12A1	chr15	48513118	+	5443	1504	163	4251	1362
ENST00000369496	ATP1A1	chr1	116933513	+	ENST00000396577	SLC12A1	chr15	48513118	+	5445	1504	163	4251	1362
ENST00000369496	ATP1A1	chr1	116933513	+	ENST00000330289	SLC12A1	chr15	48513118	+	2530	1504	163	2244	693
ENST00000369496	ATP1A1	chr1	116933513	+	ENST00000558405	SLC12A1	chr15	48513118	+	4364	1504	163	4251	1362
ENST00000369496	ATP1A1	chr1	116933513	+	ENST00000561031	SLC12A1	chr15	48513118	+	1687	1504	163	1605	480

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000295598	ENST00000380993	ATP1A1	chr1	116933513	+	SLC12A1	chr15	48513118	+	0.00043349	0.9995665
ENST00000295598	ENST00000396577	ATP1A1	chr1	116933513	+	SLC12A1	chr15	48513118	+	0.000426644	0.9995734
ENST00000295598	ENST00000330289	ATP1A1	chr1	116933513	+	SLC12A1	chr15	48513118	+	0.003072459	0.99692756
ENST00000295598	ENST00000558405	ATP1A1	chr1	116933513	+	SLC12A1	chr15	48513118	+	0.000816806	0.99918324
ENST00000295598	ENST00000561031	ATP1A1	chr1	116933513	+	SLC12A1	chr15	48513118	+	0.002307956	0.9976921
ENST00000537345	ENST00000380993	ATP1A1	chr1	116933513	+	SLC12A1	chr15	48513118	+	0.00040397	0.99959606
ENST00000537345	ENST00000396577	ATP1A1	chr1	116933513	+	SLC12A1	chr15	48513118	+	0.000396094	0.9996039
ENST00000537345	ENST00000330289	ATP1A1	chr1	116933513	+	SLC12A1	chr15	48513118	+	0.00179055	0.9982095
ENST00000537345	ENST00000558405	ATP1A1	chr1	116933513	+	SLC12A1	chr15	48513118	+	0.000681139	0.99931884
ENST00000537345	ENST00000561031	ATP1A1	chr1	116933513	+	SLC12A1	chr15	48513118	+	0.001931676	0.9980684
ENST00000369496	ENST00000380993	ATP1A1	chr1	116933513	+	SLC12A1	chr15	48513118	+	0.000346293	0.9996537
ENST00000369496	ENST00000396577	ATP1A1	chr1	116933513	+	SLC12A1	chr15	48513118	+	0.000334278	0.99966574
ENST00000369496	ENST00000330289	ATP1A1	chr1	116933513	+	SLC12A1	chr15	48513118	+	0.002072649	0.9979273
ENST00000369496	ENST00000558405	ATP1A1	chr1	116933513	+	SLC12A1	chr15	48513118	+	0.000598687	0.99940133
ENST00000369496	ENST00000561031	ATP1A1	chr1	116933513	+	SLC12A1	chr15	48513118	+	0.001999205	0.9980008

Predicted full-length fusion amino acid sequences. For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among all the predicted ones.

Get the fusion protein sequences from here.

Fusion protein sequence information is available in the fasta format.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

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Fusion Protein Breakpoint Sequences for ATP1A1-SLC12A1

+/-13 AA sequence from the breakpoints of the fusion protein sequences.

Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	Length(fusion protein)	BP in fusion protein	Peptide
ATP1A1	chr1	116933513	SLC12A1	chr15	48513118	1504	447	VFQANQENLPILKVRCMLNIWGVMLF
ATP1A1	chr1	116933513	SLC12A1	chr15	48513118	1584	449	VFQANQENLPILKVRCMLNIWGVMLF
ATP1A1	chr1	116933513	SLC12A1	chr15	48513118	1695	459	VFQANQENLPILKVRCMLNIWGVMLF

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Potential FusionNeoAntigen Information of ATP1A1-SLC12A1 in HLA I

Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.

ATP1A1-SLC12A1_116933513_48513118.msa

Potential FusionNeoAntigen Information
* We used NetMHCpan v4.1 (%rank<0.5) and deepHLApan v1.1 (immunogenic score>0.5)

Fusion gene	Hchr	Hbp	Tgene	Tchr	Tbp	HLA I	FusionNeoAntigen peptide	Binding score	Immunogenic score	Neoantigen start (at BP 13)	Neoantigen end (at BP 13)
ATP1A1-SLC12A1	chr1	116933513	chr15	48513118	1584	HLA-B08:01	ILKVRCML	0.9993	0.5088	10	18
ATP1A1-SLC12A1	chr1	116933513	chr15	48513118	1584	HLA-B45:01	QENLPILKV	0.9995	0.9325	5	14
ATP1A1-SLC12A1	chr1	116933513	chr15	48513118	1584	HLA-B57:01	KVRCMLNIW	0.999	0.9592	12	21
ATP1A1-SLC12A1	chr1	116933513	chr15	48513118	1584	HLA-B50:02	QENLPILKV	0.999	0.5968	5	14
ATP1A1-SLC12A1	chr1	116933513	chr15	48513118	1584	HLA-B13:01	QENLPILKV	0.9843	0.926	5	14
ATP1A1-SLC12A1	chr1	116933513	chr15	48513118	1584	HLA-B44:03	QENLPILKV	0.978	0.9605	5	14
ATP1A1-SLC12A1	chr1	116933513	chr15	48513118	1584	HLA-B08:01	LPILKVRCM	0.9754	0.7693	8	17
ATP1A1-SLC12A1	chr1	116933513	chr15	48513118	1584	HLA-B35:01	LPILKVRCM	0.9636	0.6979	8	17
ATP1A1-SLC12A1	chr1	116933513	chr15	48513118	1584	HLA-B08:09	LPILKVRCM	0.9605	0.6785	8	17
ATP1A1-SLC12A1	chr1	116933513	chr15	48513118	1584	HLA-B35:03	LPILKVRCM	0.9302	0.742	8	17
ATP1A1-SLC12A1	chr1	116933513	chr15	48513118	1584	HLA-B47:01	QENLPILKV	0.9277	0.513	5	14
ATP1A1-SLC12A1	chr1	116933513	chr15	48513118	1584	HLA-B41:01	QENLPILKV	0.6841	0.9622	5	14
ATP1A1-SLC12A1	chr1	116933513	chr15	48513118	1584	HLA-B35:02	LPILKVRCM	0.6474	0.8005	8	17
ATP1A1-SLC12A1	chr1	116933513	chr15	48513118	1584	HLA-B35:04	LPILKVRCM	0.6474	0.8005	8	17
ATP1A1-SLC12A1	chr1	116933513	chr15	48513118	1584	HLA-B50:01	QENLPILKV	0.5528	0.6519	5	14
ATP1A1-SLC12A1	chr1	116933513	chr15	48513118	1584	HLA-B39:13	QENLPILKV	0.2593	0.8952	5	14
ATP1A1-SLC12A1	chr1	116933513	chr15	48513118	1584	HLA-B52:01	QENLPILKV	0.2366	0.8145	5	14
ATP1A1-SLC12A1	chr1	116933513	chr15	48513118	1584	HLA-B40:06	QENLPILKV	0.999	0.6466	5	14
ATP1A1-SLC12A1	chr1	116933513	chr15	48513118	1584	HLA-B42:02	LPILKVRCM	0.9828	0.7904	8	17
ATP1A1-SLC12A1	chr1	116933513	chr15	48513118	1584	HLA-B42:01	LPILKVRCM	0.9729	0.7827	8	17
ATP1A1-SLC12A1	chr1	116933513	chr15	48513118	1584	HLA-B35:12	LPILKVRCM	0.6474	0.8005	8	17
ATP1A1-SLC12A1	chr1	116933513	chr15	48513118	1584	HLA-B39:08	QENLPILKV	0.5777	0.9006	5	14
ATP1A1-SLC12A1	chr1	116933513	chr15	48513118	1584	HLA-B39:10	LPILKVRCM	0.3659	0.7511	8	17
ATP1A1-SLC12A1	chr1	116933513	chr15	48513118	1584	HLA-B51:07	QENLPILKV	0.1969	0.6872	5	14
ATP1A1-SLC12A1	chr1	116933513	chr15	48513118	1584	HLA-B08:18	ILKVRCML	0.9993	0.5088	10	18
ATP1A1-SLC12A1	chr1	116933513	chr15	48513118	1584	HLA-B57:10	KVRCMLNIW	0.999	0.9592	12	21
ATP1A1-SLC12A1	chr1	116933513	chr15	48513118	1584	HLA-B58:06	KVRCMLNIW	0.9968	0.6874	12	21
ATP1A1-SLC12A1	chr1	116933513	chr15	48513118	1584	HLA-B40:04	QENLPILKV	0.9913	0.6947	5	14
ATP1A1-SLC12A1	chr1	116933513	chr15	48513118	1584	HLA-A32:01	KVRCMLNIW	0.9907	0.9796	12	21
ATP1A1-SLC12A1	chr1	116933513	chr15	48513118	1584	HLA-B44:26	QENLPILKV	0.978	0.9605	5	14
ATP1A1-SLC12A1	chr1	116933513	chr15	48513118	1584	HLA-B44:07	QENLPILKV	0.978	0.9605	5	14
ATP1A1-SLC12A1	chr1	116933513	chr15	48513118	1584	HLA-B44:13	QENLPILKV	0.978	0.9605	5	14
ATP1A1-SLC12A1	chr1	116933513	chr15	48513118	1584	HLA-B08:18	LPILKVRCM	0.9754	0.7693	8	17
ATP1A1-SLC12A1	chr1	116933513	chr15	48513118	1584	HLA-B35:77	LPILKVRCM	0.9636	0.6979	8	17
ATP1A1-SLC12A1	chr1	116933513	chr15	48513118	1584	HLA-B35:23	LPILKVRCM	0.9585	0.6677	8	17
ATP1A1-SLC12A1	chr1	116933513	chr15	48513118	1584	HLA-B35:24	LPILKVRCM	0.901	0.6683	8	17
ATP1A1-SLC12A1	chr1	116933513	chr15	48513118	1584	HLA-B35:11	LPILKVRCM	0.8418	0.7497	8	17
ATP1A1-SLC12A1	chr1	116933513	chr15	48513118	1584	HLA-B41:03	QENLPILKV	0.8134	0.72	5	14
ATP1A1-SLC12A1	chr1	116933513	chr15	48513118	1584	HLA-B18:11	QENLPILKV	0.7684	0.836	5	14
ATP1A1-SLC12A1	chr1	116933513	chr15	48513118	1584	HLA-B08:12	LPILKVRCM	0.7395	0.8555	8	17
ATP1A1-SLC12A1	chr1	116933513	chr15	48513118	1584	HLA-B18:03	QENLPILKV	0.7175	0.8148	5	14
ATP1A1-SLC12A1	chr1	116933513	chr15	48513118	1584	HLA-B35:09	LPILKVRCM	0.6474	0.8005	8	17
ATP1A1-SLC12A1	chr1	116933513	chr15	48513118	1584	HLA-B50:04	QENLPILKV	0.5528	0.6519	5	14
ATP1A1-SLC12A1	chr1	116933513	chr15	48513118	1584	HLA-B50:05	QENLPILKV	0.5528	0.6519	5	14
ATP1A1-SLC12A1	chr1	116933513	chr15	48513118	1584	HLA-B67:01	LPILKVRCM	0.4594	0.6314	8	17
ATP1A1-SLC12A1	chr1	116933513	chr15	48513118	1584	HLA-B39:02	QENLPILKV	0.271	0.8909	5	14
ATP1A1-SLC12A1	chr1	116933513	chr15	48513118	1584	HLA-B18:07	LPILKVRCM	0.1135	0.6408	8	17
ATP1A1-SLC12A1	chr1	116933513	chr15	48513118	1584	HLA-B35:43	LPILKVRCM	0.0054	0.5829	8	17
ATP1A1-SLC12A1	chr1	116933513	chr15	48513118	1584	HLA-B15:08	LPILKVRCM	0.005	0.5846	8	17
ATP1A1-SLC12A1	chr1	116933513	chr15	48513118	1584	HLA-B15:11	LPILKVRCM	0.0048	0.5912	8	17

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Potential FusionNeoAntigen Information of ATP1A1-SLC12A1 in HLA II

Potential FusionNeoAntigen Information
* We used NetMHCIIpan v4.1 (%rank<0.5).

Fusion gene

Hchr

Hbp

Tgene

Tchr

Tbp

HLA II

FusionNeoAntigen peptide

Neoantigen start (at BP 13)

Neoantigen end (at BP 13)

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Fusion breakpoint peptide structures of ATP1A1-SLC12A1

3D structures of the fusion breakpoint peptide of 14AA sequence that have potential fusion neoantigens
* The minimum length of the amino acid sequence in RoseTTAFold is 14AA. Here, we predicted the 14AA fusion protein breakpoint sequence not the fusion neoantigen peptide, which is shorter than 14 AA.

File name	BPseq	Hgene	Tgene	Hchr	Hbp	Tchr	Tbp	AAlen
1985	ENLPILKVRCMLNI	ATP1A1	SLC12A1	chr1	116933513	chr15	48513118	1584

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Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D of ATP1A1-SLC12A1

Virtual screening between 25 HLAs (from PDB) and FusionNeoAntigens
* We used Glide to predict the interaction between HLAs and neoantigens.

HLA allele	PDB ID	File name	BPseq	Docking score	Glide score
HLA-B14:02	3BVN	1985	ENLPILKVRCMLNI	-7.9962	-8.1096
HLA-B14:02	3BVN	1985	ENLPILKVRCMLNI	-5.70842	-6.74372
HLA-B52:01	3W39	1985	ENLPILKVRCMLNI	-6.83737	-6.95077
HLA-B52:01	3W39	1985	ENLPILKVRCMLNI	-4.4836	-5.5189
HLA-A11:01	4UQ2	1985	ENLPILKVRCMLNI	-10.0067	-10.1201
HLA-A11:01	4UQ2	1985	ENLPILKVRCMLNI	-9.03915	-10.0745
HLA-A24:02	5HGA	1985	ENLPILKVRCMLNI	-6.56204	-6.67544
HLA-A24:02	5HGA	1985	ENLPILKVRCMLNI	-5.42271	-6.45801
HLA-B44:05	3DX8	1985	ENLPILKVRCMLNI	-7.85648	-8.89178
HLA-B44:05	3DX8	1985	ENLPILKVRCMLNI	-5.3978	-5.5112
HLA-A02:01	6TDR	1985	ENLPILKVRCMLNI	-3.37154	-4.40684

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Vaccine Design for the FusionNeoAntigens of ATP1A1-SLC12A1

mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-Is.

Fusion gene	Hchr	Hbp	Tchr	Tbp	Start in +/-13AA	End in +/-13AA	FusionNeoAntigen peptide sequence	FusionNeoAntigen RNA sequence
ATP1A1-SLC12A1	chr1	116933513	chr15	48513118	10	18	ILKVRCML	ATTCTTAAGGTAAGATGCATGCTG
ATP1A1-SLC12A1	chr1	116933513	chr15	48513118	12	21	KVRCMLNIW	AAGGTAAGATGCATGCTGAACATCTGG
ATP1A1-SLC12A1	chr1	116933513	chr15	48513118	5	14	QENLPILKV	CAGGAAAACCTACCTATTCTTAAGGTA
ATP1A1-SLC12A1	chr1	116933513	chr15	48513118	8	17	LPILKVRCM	CTACCTATTCTTAAGGTAAGATGCATG

mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-IIs.

Fusion gene

Hchr

Hbp

Tchr

Tbp

Start in +/-13AA

End in +/-13AA

FusionNeoAntigen peptide

FusionNEoAntigen RNA sequence

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Information of the samples that have these potential fusion neoantigens of ATP1A1-SLC12A1

These samples were reported as having these fusion breakpoints. For individual breakpoints, we checked the open reading frames considering multiple gene isoforms and chose the in-frame fusion genes only. Then, we made fusion protein sequences and predicted the fusion neoantigens. These fusion-positive samples may have these potential fusion neoantigens.

Cancer type	Fusion gene	Hchr	Hbp	Henst	Tchr	Tbp	Tenst	Sample
Non-Cancer	ATP1A1-SLC12A1	chr1	116933513	ENST00000295598	chr15	48513118	ENST00000330289	TCGA-CZ-5469-11A

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Potential target of CAR-T therapy development for ATP1A1-SLC12A1

Predicted 3D structure. We used RoseTTAFold.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, to provide the retention of the transmembrane domain, we only show the protein feature retention information of those transmembrane features

* Minus value of BPloci means that the break point is located before the CDS.

- In-frame and retained 'Transmembrane'.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ATP1A1

chr1:116933513

chr15:48513118

ENST00000295598

132_152

444

1024.0

Transmembrane

Helical

Hgene

ATP1A1

chr1:116933513

chr15:48513118

ENST00000295598

289_308

444

1024.0

Transmembrane

Helical

Hgene

ATP1A1

chr1:116933513

chr15:48513118

ENST00000295598

321_338

444

1024.0

Transmembrane

Helical

Hgene

ATP1A1

chr1:116933513

chr15:48513118

ENST00000295598

88_108

444

1024.0

Transmembrane

Helical

Hgene

ATP1A1

chr1:116933513

chr15:48513118

ENST00000369496

132_152

413

993.0

Transmembrane

Helical

Hgene

ATP1A1

chr1:116933513

chr15:48513118

ENST00000369496

289_308

413

993.0

Transmembrane

Helical

Hgene

ATP1A1

chr1:116933513

chr15:48513118

ENST00000369496

321_338

413

993.0

Transmembrane

Helical

Hgene

ATP1A1

chr1:116933513

chr15:48513118

ENST00000369496

88_108

413

993.0

Transmembrane

Helical

Hgene

ATP1A1

chr1:116933513

chr15:48513118

ENST00000537345

132_152

444

1024.0

Transmembrane

Helical

Hgene

ATP1A1

chr1:116933513

chr15:48513118

ENST00000537345

289_308

444

1024.0

Transmembrane

Helical

Hgene

ATP1A1

chr1:116933513

chr15:48513118

ENST00000537345

321_338

444

1024.0

Transmembrane

Helical

Hgene

ATP1A1

chr1:116933513

chr15:48513118

ENST00000537345

88_108

444

1024.0

Transmembrane

Helical

Tgene

SLC12A1

chr1:116933513

chr15:48513118

ENST00000380993

202_222

1100.0

Transmembrane

Helical

Tgene

SLC12A1

chr1:116933513

chr15:48513118

ENST00000380993

260_280

1100.0

Transmembrane

Helical

Tgene

SLC12A1

chr1:116933513

chr15:48513118

ENST00000380993

303_323

1100.0

Transmembrane

Helical

Tgene

SLC12A1

chr1:116933513

chr15:48513118

ENST00000380993

328_348

1100.0

Transmembrane

Helical

Tgene

SLC12A1

chr1:116933513

chr15:48513118

ENST00000380993

380_400

1100.0

Transmembrane

Helical

Tgene

SLC12A1

chr1:116933513

chr15:48513118

ENST00000380993

418_438

1100.0

Transmembrane

Helical

Tgene

SLC12A1

chr1:116933513

chr15:48513118

ENST00000380993

485_505

1100.0

Transmembrane

Helical

Tgene

SLC12A1

chr1:116933513

chr15:48513118

ENST00000380993

551_571

1100.0

Transmembrane

Helical

Tgene

SLC12A1

chr1:116933513

chr15:48513118

ENST00000380993

572_592

1100.0

Transmembrane

Helical

Tgene

SLC12A1

chr1:116933513

chr15:48513118

ENST00000380993

610_630

1100.0

Transmembrane

Helical

Tgene

SLC12A1

chr1:116933513

chr15:48513118

ENST00000380993

793_813

1100.0

Transmembrane

Helical

Tgene

SLC12A1

chr1:116933513

chr15:48513118

ENST00000558405

202_222

1100.0

Transmembrane

Helical

Tgene

SLC12A1

chr1:116933513

chr15:48513118

ENST00000558405

260_280

1100.0

Transmembrane

Helical

Tgene

SLC12A1

chr1:116933513

chr15:48513118

ENST00000558405

303_323

1100.0

Transmembrane

Helical

Tgene

SLC12A1

chr1:116933513

chr15:48513118

ENST00000558405

328_348

1100.0

Transmembrane

Helical

Tgene

SLC12A1

chr1:116933513

chr15:48513118

ENST00000558405

380_400

1100.0

Transmembrane

Helical

Tgene

SLC12A1

chr1:116933513

chr15:48513118

ENST00000558405

418_438

1100.0

Transmembrane

Helical

Tgene

SLC12A1

chr1:116933513

chr15:48513118

ENST00000558405

485_505

1100.0

Transmembrane

Helical

Tgene

SLC12A1

chr1:116933513

chr15:48513118

ENST00000558405

551_571

1100.0

Transmembrane

Helical

Tgene

SLC12A1

chr1:116933513

chr15:48513118

ENST00000558405

572_592

1100.0

Transmembrane

Helical

Tgene

SLC12A1

chr1:116933513

chr15:48513118

ENST00000558405

610_630

1100.0

Transmembrane

Helical

Tgene

SLC12A1

chr1:116933513

chr15:48513118

ENST00000558405

793_813

1100.0

Transmembrane

Helical

Subcellular localization prediction of the transmembrane domain retained fusion proteins
* We used DeepLoc 1.0. The order of the X-axis of the barplot is as follows: Entry_ID, Localization, Type, Nucleus, Cytoplasm, Extracellular, Mitochondrion, Cell_membrane, Endoplasmic_reticulum, Plastid, Golgi.apparatus, Lysosome.Vacuole, Peroxisome. Y-axis is the output score of DeepLoc. Clicking the image will open a new tab with a large image.

Hgene

Hchr

Hbp

Henst

Tgene

Tchr

Tbp

Tenst

DeepLoc result

Top

Related Drugs to ATP1A1-SLC12A1

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to ATP1A1-SLC12A1

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source

	Fusion Gene and Fusion Protein Summary
	Fusion Amino Acid Sequences (multiple BPs and multiple gene isoforms)
	Fusion Protein Breakpoint Sequences - (for the Screening of the FusionNeoAntigens)
	Potential FusionNeoAntigens in HLA I - (netMHCpan v4.1 + deepHLApan v1.1)
	Potential FusionNeoAntigens in HLA II - (netMHCIIpan v4.1)
	Fusion Breakpoint 14 AA Peptide Structure - (RoseTTAFold)
	Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D - (Glide)
	Vaccine Design for the FusionNeoAntigens (RNA/protein sequences)
	Potential target of CAR-T therapy development
	Information on the samples that have these potential fusion neoantigens
	Fusion Protein Targeting Drugs - (Manual Curation)
	Fusion Protein Related diseases - (Manual Curation)