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Center for Computational Systems Medicine
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Fusion Gene and Fusion Protein Summary

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Fusion Amino Acid Sequences (multiple BPs and multiple gene isoforms)

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Fusion Protein Breakpoint Sequences - (for the Screening of the FusionNeoAntigens)

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Potential FusionNeoAntigens in HLA I - (netMHCpan v4.1 + deepHLApan v1.1)

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Potential FusionNeoAntigens in HLA II - (netMHCIIpan v4.1)

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Fusion Breakpoint 14 AA Peptide Structure - (RoseTTAFold)

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Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D - (Glide)

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Vaccine Design for the FusionNeoAntigens (RNA/protein sequences)

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Potential target of CAR-T therapy development

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Information on the samples that have these potential fusion neoantigens

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Fusion Protein Targeting Drugs - (Manual Curation)

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Fusion Protein Related diseases - (Manual Curation)

Fusion Protein:RTN4RL2-CTNND1

Fusion Gene and Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: RTN4RL2-CTNND1
FusionPDB ID: 78587
FusionGDB2.0 ID: 78587
HgeneTgene
Gene symbol

RTN4RL2

CTNND1

Gene ID

349667

100528016

Gene namereticulon 4 receptor like 2TMX2-CTNND1 readthrough (NMD candidate)
SynonymsNGRH1|NgR2CAS|CTNND1|p120(cas)|p120(ctn)
Cytomap

11q12.1

11q12.1

Type of geneprotein-codingncRNA
Descriptionreticulon-4 receptor-like 2Nogo-66 receptor homolog 1nogo receptor-like 3nogo-66 receptor-related protein 2Cadherin-associated Src substrateCatenin delta-1TMX2-CTNND1 readthrough (non-protein coding)p120 catenin
Modification date2020031320200313
UniProtAcc.

O60716

Main function of 5'-partner protein: FUNCTION: Key regulator of cell-cell adhesion that associates with and regulates the cell adhesion properties of both C-, E- and N-cadherins, being critical for their surface stability (PubMed:14610055, PubMed:20371349). Beside cell-cell adhesion, regulates gene transcription through several transcription factors including ZBTB33/Kaiso2 and GLIS2, and the activity of Rho family GTPases and downstream cytoskeletal dynamics (PubMed:10207085, PubMed:20371349). Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors (PubMed:17344476). {ECO:0000269|PubMed:10207085, ECO:0000269|PubMed:14610055, ECO:0000269|PubMed:17344476, ECO:0000269|PubMed:20371349}.
Ensembl transtripts involved in fusion geneENST idsENST00000335099, ENST00000395120, 
ENST00000533205, 		ENST00000361332, 
ENST00000399050, ENST00000415361, 
ENST00000426142, ENST00000428599, 
ENST00000526357, ENST00000526938, 
ENST00000528232, ENST00000528621, 
ENST00000529526, ENST00000529873, 
ENST00000529986, ENST00000530094, 
ENST00000530748, ENST00000532245, 
ENST00000532463, ENST00000532649, 
ENST00000532787, ENST00000532844, 
ENST00000534579, ENST00000358694, 
ENST00000525902, ENST00000526772, 
ENST00000527467, ENST00000531014, 
ENST00000533667, ENST00000360682, 
ENST00000361391, ENST00000361796, 
ENST00000399039, ENST00000524630, 
ENST00000529919, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score2 X 1 X 2=417 X 21 X 10=3570
# samples 325
** MAII scorelog2(3/4*10)=2.90689059560852log2(25/3570*10)=-3.83592407425437
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Fusion gene context

PubMed: RTN4RL2 [Title/Abstract] AND CTNND1 [Title/Abstract] AND fusion [Title/Abstract]

Fusion neoantigen context

PubMed: RTN4RL2 [Title/Abstract] AND CTNND1 [Title/Abstract] AND neoantigen [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)RTN4RL2(57235563)-CTNND1(57561482), # samples:2
Anticipated loss of major functional domain due to fusion event.RTN4RL2-CTNND1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
RTN4RL2-CTNND1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
RTN4RL2-CTNND1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
RTN4RL2-CTNND1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
RTN4RL2-CTNND1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
RTN4RL2-CTNND1 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
RTN4RL2-CTNND1 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:57235563/chr11:57561482)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonRetention analysis results of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features, are available here.

check buttonFusion gene breakpoints across RTN4RL2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CTNND1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Amino Acid Sequences


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000335099RTN4RL2chr1157235563+ENST00000524630CTNND1chr1157561482+66758302034361138
ENST00000335099RTN4RL2chr1157235563+ENST00000529919CTNND1chr1157561482+50848302034511143
ENST00000335099RTN4RL2chr1157235563+ENST00000399039CTNND1chr1157561482+54928302034511143
ENST00000335099RTN4RL2chr1157235563+ENST00000360682CTNND1chr1157561482+63508302034781152
ENST00000335099RTN4RL2chr1157235563+ENST00000361796CTNND1chr1157561482+63088302034361138
ENST00000335099RTN4RL2chr1157235563+ENST00000361391CTNND1chr1157561482+63318302034601146
ENST00000533205RTN4RL2chr1157235563+ENST00000524630CTNND1chr1157561482+6367522931281039
ENST00000533205RTN4RL2chr1157235563+ENST00000529919CTNND1chr1157561482+4776522931431044
ENST00000533205RTN4RL2chr1157235563+ENST00000399039CTNND1chr1157561482+5184522931431044
ENST00000533205RTN4RL2chr1157235563+ENST00000360682CTNND1chr1157561482+6042522931701053
ENST00000533205RTN4RL2chr1157235563+ENST00000361796CTNND1chr1157561482+6000522931281039
ENST00000533205RTN4RL2chr1157235563+ENST00000361391CTNND1chr1157561482+6023522931521047
ENST00000395120RTN4RL2chr1157235563+ENST00000524630CTNND1chr1157561482+6358513031191039
ENST00000395120RTN4RL2chr1157235563+ENST00000529919CTNND1chr1157561482+4767513031341044
ENST00000395120RTN4RL2chr1157235563+ENST00000399039CTNND1chr1157561482+5175513031341044
ENST00000395120RTN4RL2chr1157235563+ENST00000360682CTNND1chr1157561482+6033513031611053
ENST00000395120RTN4RL2chr1157235563+ENST00000361796CTNND1chr1157561482+5991513031191039
ENST00000395120RTN4RL2chr1157235563+ENST00000361391CTNND1chr1157561482+6014513031431047
ENST00000335099RTN4RL2chr1157235563+ENST00000524630CTNND1chr1157561481+66758302034361138
ENST00000335099RTN4RL2chr1157235563+ENST00000529919CTNND1chr1157561481+50848302034511143
ENST00000335099RTN4RL2chr1157235563+ENST00000399039CTNND1chr1157561481+54928302034511143
ENST00000335099RTN4RL2chr1157235563+ENST00000360682CTNND1chr1157561481+63508302034781152
ENST00000335099RTN4RL2chr1157235563+ENST00000361796CTNND1chr1157561481+63088302034361138
ENST00000335099RTN4RL2chr1157235563+ENST00000361391CTNND1chr1157561481+63318302034601146
ENST00000533205RTN4RL2chr1157235563+ENST00000524630CTNND1chr1157561481+6367522931281039
ENST00000533205RTN4RL2chr1157235563+ENST00000529919CTNND1chr1157561481+4776522931431044
ENST00000533205RTN4RL2chr1157235563+ENST00000399039CTNND1chr1157561481+5184522931431044
ENST00000533205RTN4RL2chr1157235563+ENST00000360682CTNND1chr1157561481+6042522931701053
ENST00000533205RTN4RL2chr1157235563+ENST00000361796CTNND1chr1157561481+6000522931281039
ENST00000533205RTN4RL2chr1157235563+ENST00000361391CTNND1chr1157561481+6023522931521047
ENST00000395120RTN4RL2chr1157235563+ENST00000524630CTNND1chr1157561481+6358513031191039
ENST00000395120RTN4RL2chr1157235563+ENST00000529919CTNND1chr1157561481+4767513031341044
ENST00000395120RTN4RL2chr1157235563+ENST00000399039CTNND1chr1157561481+5175513031341044
ENST00000395120RTN4RL2chr1157235563+ENST00000360682CTNND1chr1157561481+6033513031611053
ENST00000395120RTN4RL2chr1157235563+ENST00000361796CTNND1chr1157561481+5991513031191039
ENST00000395120RTN4RL2chr1157235563+ENST00000361391CTNND1chr1157561481+6014513031431047
ENST00000335099RTN4RL2chr1157235563+ENST00000524630CTNND1chr1157563049+66038302033641114
ENST00000335099RTN4RL2chr1157235563+ENST00000529919CTNND1chr1157563049+50128302033791119
ENST00000335099RTN4RL2chr1157235563+ENST00000399039CTNND1chr1157563049+54208302033791119
ENST00000335099RTN4RL2chr1157235563+ENST00000360682CTNND1chr1157563049+62788302034061128
ENST00000335099RTN4RL2chr1157235563+ENST00000361796CTNND1chr1157563049+62368302033641114
ENST00000335099RTN4RL2chr1157235563+ENST00000361391CTNND1chr1157563049+62598302033881122
ENST00000533205RTN4RL2chr1157235563+ENST00000524630CTNND1chr1157563049+6295522930561015
ENST00000533205RTN4RL2chr1157235563+ENST00000529919CTNND1chr1157563049+4704522930711020
ENST00000533205RTN4RL2chr1157235563+ENST00000399039CTNND1chr1157563049+5112522930711020
ENST00000533205RTN4RL2chr1157235563+ENST00000360682CTNND1chr1157563049+5970522930981029
ENST00000533205RTN4RL2chr1157235563+ENST00000361796CTNND1chr1157563049+5928522930561015
ENST00000533205RTN4RL2chr1157235563+ENST00000361391CTNND1chr1157563049+5951522930801023
ENST00000395120RTN4RL2chr1157235563+ENST00000524630CTNND1chr1157563049+6286513030471015
ENST00000395120RTN4RL2chr1157235563+ENST00000529919CTNND1chr1157563049+4695513030621020
ENST00000395120RTN4RL2chr1157235563+ENST00000399039CTNND1chr1157563049+5103513030621020
ENST00000395120RTN4RL2chr1157235563+ENST00000360682CTNND1chr1157563049+5961513030891029
ENST00000395120RTN4RL2chr1157235563+ENST00000361796CTNND1chr1157563049+5919513030471015
ENST00000395120RTN4RL2chr1157235563+ENST00000361391CTNND1chr1157563049+5942513030711023

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000335099ENST00000524630RTN4RL2chr1157235563+CTNND1chr1157561482+0.0013856660.9986143
ENST00000335099ENST00000529919RTN4RL2chr1157235563+CTNND1chr1157561482+0.0036605080.99633956
ENST00000335099ENST00000399039RTN4RL2chr1157235563+CTNND1chr1157561482+0.0021365290.9978635
ENST00000335099ENST00000360682RTN4RL2chr1157235563+CTNND1chr1157561482+0.0009128360.9990872
ENST00000335099ENST00000361796RTN4RL2chr1157235563+CTNND1chr1157561482+0.001576140.99842393
ENST00000335099ENST00000361391RTN4RL2chr1157235563+CTNND1chr1157561482+0.0010227010.9989773
ENST00000533205ENST00000524630RTN4RL2chr1157235563+CTNND1chr1157561482+0.000952440.9990476
ENST00000533205ENST00000529919RTN4RL2chr1157235563+CTNND1chr1157561482+0.0028150630.99718493
ENST00000533205ENST00000399039RTN4RL2chr1157235563+CTNND1chr1157561482+0.0014872840.9985127
ENST00000533205ENST00000360682RTN4RL2chr1157235563+CTNND1chr1157561482+0.0006192280.9993807
ENST00000533205ENST00000361796RTN4RL2chr1157235563+CTNND1chr1157561482+0.0010830190.998917
ENST00000533205ENST00000361391RTN4RL2chr1157235563+CTNND1chr1157561482+0.0007124490.99928755
ENST00000395120ENST00000524630RTN4RL2chr1157235563+CTNND1chr1157561482+0.0009347070.99906534
ENST00000395120ENST00000529919RTN4RL2chr1157235563+CTNND1chr1157561482+0.0027673220.99723274
ENST00000395120ENST00000399039RTN4RL2chr1157235563+CTNND1chr1157561482+0.0014540210.998546
ENST00000395120ENST00000360682RTN4RL2chr1157235563+CTNND1chr1157561482+0.0006060420.99939394
ENST00000395120ENST00000361796RTN4RL2chr1157235563+CTNND1chr1157561482+0.0010635870.99893636
ENST00000395120ENST00000361391RTN4RL2chr1157235563+CTNND1chr1157561482+0.0006976930.99930227
ENST00000335099ENST00000524630RTN4RL2chr1157235563+CTNND1chr1157561481+0.0013856660.9986143
ENST00000335099ENST00000529919RTN4RL2chr1157235563+CTNND1chr1157561481+0.0036605080.99633956
ENST00000335099ENST00000399039RTN4RL2chr1157235563+CTNND1chr1157561481+0.0021365290.9978635
ENST00000335099ENST00000360682RTN4RL2chr1157235563+CTNND1chr1157561481+0.0009128360.9990872
ENST00000335099ENST00000361796RTN4RL2chr1157235563+CTNND1chr1157561481+0.001576140.99842393
ENST00000335099ENST00000361391RTN4RL2chr1157235563+CTNND1chr1157561481+0.0010227010.9989773
ENST00000533205ENST00000524630RTN4RL2chr1157235563+CTNND1chr1157561481+0.000952440.9990476
ENST00000533205ENST00000529919RTN4RL2chr1157235563+CTNND1chr1157561481+0.0028150630.99718493
ENST00000533205ENST00000399039RTN4RL2chr1157235563+CTNND1chr1157561481+0.0014872840.9985127
ENST00000533205ENST00000360682RTN4RL2chr1157235563+CTNND1chr1157561481+0.0006192280.9993807
ENST00000533205ENST00000361796RTN4RL2chr1157235563+CTNND1chr1157561481+0.0010830190.998917
ENST00000533205ENST00000361391RTN4RL2chr1157235563+CTNND1chr1157561481+0.0007124490.99928755
ENST00000395120ENST00000524630RTN4RL2chr1157235563+CTNND1chr1157561481+0.0009347070.99906534
ENST00000395120ENST00000529919RTN4RL2chr1157235563+CTNND1chr1157561481+0.0027673220.99723274
ENST00000395120ENST00000399039RTN4RL2chr1157235563+CTNND1chr1157561481+0.0014540210.998546
ENST00000395120ENST00000360682RTN4RL2chr1157235563+CTNND1chr1157561481+0.0006060420.99939394
ENST00000395120ENST00000361796RTN4RL2chr1157235563+CTNND1chr1157561481+0.0010635870.99893636
ENST00000395120ENST00000361391RTN4RL2chr1157235563+CTNND1chr1157561481+0.0006976930.99930227
ENST00000335099ENST00000524630RTN4RL2chr1157235563+CTNND1chr1157563049+0.0012085970.9987914
ENST00000335099ENST00000529919RTN4RL2chr1157235563+CTNND1chr1157563049+0.0035783640.9964217
ENST00000335099ENST00000399039RTN4RL2chr1157235563+CTNND1chr1157563049+0.0020354970.9979645
ENST00000335099ENST00000360682RTN4RL2chr1157235563+CTNND1chr1157563049+0.0009141950.9990858
ENST00000335099ENST00000361796RTN4RL2chr1157235563+CTNND1chr1157563049+0.0013821760.99861777
ENST00000335099ENST00000361391RTN4RL2chr1157235563+CTNND1chr1157563049+0.0012613640.9987387
ENST00000533205ENST00000524630RTN4RL2chr1157235563+CTNND1chr1157563049+0.0008314490.9991685
ENST00000533205ENST00000529919RTN4RL2chr1157235563+CTNND1chr1157563049+0.0027388090.99726117
ENST00000533205ENST00000399039RTN4RL2chr1157235563+CTNND1chr1157563049+0.0014137150.9985863
ENST00000533205ENST00000360682RTN4RL2chr1157235563+CTNND1chr1157563049+0.0006257520.99937433
ENST00000533205ENST00000361796RTN4RL2chr1157235563+CTNND1chr1157563049+0.0009579770.999042
ENST00000533205ENST00000361391RTN4RL2chr1157235563+CTNND1chr1157563049+0.0008783410.9991216
ENST00000395120ENST00000524630RTN4RL2chr1157235563+CTNND1chr1157563049+0.0008136090.99918634
ENST00000395120ENST00000529919RTN4RL2chr1157235563+CTNND1chr1157563049+0.0026824010.9973176
ENST00000395120ENST00000399039RTN4RL2chr1157235563+CTNND1chr1157563049+0.0013816860.99861836
ENST00000395120ENST00000360682RTN4RL2chr1157235563+CTNND1chr1157563049+0.0006124280.9993875
ENST00000395120ENST00000361796RTN4RL2chr1157235563+CTNND1chr1157563049+0.0009391830.9990608
ENST00000395120ENST00000361391RTN4RL2chr1157235563+CTNND1chr1157563049+0.0008600110.9991399

check button Predicted full-length fusion amino acid sequences. For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among all the predicted ones.

Get the fusion protein sequences from here.

Fusion protein sequence information is available in the fasta format.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

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Fusion Protein Breakpoint Sequences for RTN4RL2-CTNND1

check button +/-13 AA sequence from the breakpoints of the fusion protein sequences.
HgeneHchrHbpTgeneTchrTbpLength(fusion protein)BP in fusion proteinPeptide

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Potential FusionNeoAntigen Information of RTN4RL2-CTNND1 in HLA I

check button Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.

check button Potential FusionNeoAntigen Information
* We used NetMHCpan v4.1 (%rank<0.5) and deepHLApan v1.1 (immunogenic score>0.5)
Fusion geneHchrHbpTgeneTchrTbpHLA IFusionNeoAntigen peptideBinding scoreImmunogenic scoreNeoantigen start (at BP 13)Neoantigen end (at BP 13)

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Potential FusionNeoAntigen Information of RTN4RL2-CTNND1 in HLA II

check button Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.

check button Potential FusionNeoAntigen Information
* We used NetMHCIIpan v4.1 (%rank<0.5).
Fusion geneHchrHbpTgeneTchrTbpHLA IIFusionNeoAntigen peptideNeoantigen start (at BP 13)Neoantigen end (at BP 13)

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Fusion breakpoint peptide structures of RTN4RL2-CTNND1

check button3D structures of the fusion breakpoint peptide of 14AA sequence that have potential fusion neoantigens
* The minimum length of the amino acid sequence in RoseTTAFold is 14AA. Here, we predicted the 14AA fusion protein breakpoint sequence not the fusion neoantigen peptide, which is shorter than 14 AA.

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Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D of RTN4RL2-CTNND1

check buttonVirtual screening between 25 HLAs (from PDB) and FusionNeoAntigens
* We used Glide to predict the interaction between HLAs and neoantigens.
HLA allelePDB IDFile nameBPseqDocking scoreGlide score

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Vaccine Design for the FusionNeoAntigens of RTN4RL2-CTNND1

check button mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-Is.
Fusion geneHchrHbpTchrTbpStart in +/-13AAEnd in +/-13AAFusionNeoAntigen peptide sequenceFusionNeoAntigen RNA sequence

check button mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-IIs.
Fusion geneHchrHbpTchrTbpStart in +/-13AAEnd in +/-13AAFusionNeoAntigen peptideFusionNEoAntigen RNA sequence

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Information of the samples that have these potential fusion neoantigens of RTN4RL2-CTNND1

check button These samples were reported as having these fusion breakpoints. For individual breakpoints, we checked the open reading frames considering multiple gene isoforms and chose the in-frame fusion genes only. Then, we made fusion protein sequences and predicted the fusion neoantigens. These fusion-positive samples may have these potential fusion neoantigens.
Cancer typeFusion geneHchrHbpHenstTchrTbpTenstSample

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Potential target of CAR-T therapy development for RTN4RL2-CTNND1

check button Predicted 3D structure. We used RoseTTAFold.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, to provide the retention of the transmembrane domain, we only show the protein feature retention information of those transmembrane features


* Minus value of BPloci means that the break point is located before the CDS.
- In-frame and retained 'Transmembrane'.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

check button Subcellular localization prediction of the transmembrane domain retained fusion proteins
* We used DeepLoc 1.0. The order of the X-axis of the barplot is as follows: Entry_ID, Localization, Type, Nucleus, Cytoplasm, Extracellular, Mitochondrion, Cell_membrane, Endoplasmic_reticulum, Plastid, Golgi.apparatus, Lysosome.Vacuole, Peroxisome. Y-axis is the output score of DeepLoc. Clicking the image will open a new tab with a large image.
HgeneHchrHbpHenstTgeneTchrTbpTenstDeepLoc result

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Related Drugs to RTN4RL2-CTNND1

check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to RTN4RL2-CTNND1

check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource