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Center for Computational Systems Medicine
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Fusion Gene and Fusion Protein Summary

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Fusion Amino Acid Sequences (multiple BPs and multiple gene isoforms)

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Fusion Protein Breakpoint Sequences - (for the Screening of the FusionNeoAntigens)

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Potential FusionNeoAntigens in HLA I - (netMHCpan v4.1 + deepHLApan v1.1)

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Potential FusionNeoAntigens in HLA II - (netMHCIIpan v4.1)

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Fusion Breakpoint 14 AA Peptide Structure - (RoseTTAFold)

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Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D - (Glide)

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Vaccine Design for the FusionNeoAntigens (RNA/protein sequences)

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Potential target of CAR-T therapy development

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Information on the samples that have these potential fusion neoantigens

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Fusion Protein Targeting Drugs - (Manual Curation)

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Fusion Protein Related diseases - (Manual Curation)

Fusion Protein:ATP5C1-ALDH7A1

Fusion Gene and Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: ATP5C1-ALDH7A1
FusionPDB ID: 7944
FusionGDB2.0 ID: 7944
HgeneTgene
Gene symbol

ATP5C1

ALDH7A1

Gene ID

509

501

Gene nameATP synthase F1 subunit gammaaldehyde dehydrogenase 7 family member A1
SynonymsATP5C|ATP5C1|ATP5CL1ATQ1|EPD|PDE
Cytomap

10p14

5q23.2

Type of geneprotein-codingprotein-coding
DescriptionATP synthase subunit gamma, mitochondrialATP synthase gamma chain, mitochondrialATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1F-ATPase gamma subunitmitochondrial ATP synthase, gamma subunit 1alpha-aminoadipic semialdehyde dehydrogenase26g turgor protein homologP6c dehydrogenasealpha-AASA dehydrogenaseantiquitin-1betaine aldehyde dehydrogenasedelta1-piperideine-6-carboxylate dehydrogenaseepididymis secretory sperm binding protein
Modification date2020032020200313
UniProtAcc.

P49419

Main function of 5'-partner protein: FUNCTION: Multifunctional enzyme mediating important protective effects. Metabolizes betaine aldehyde to betaine, an important cellular osmolyte and methyl donor. Protects cells from oxidative stress by metabolizing a number of lipid peroxidation-derived aldehydes. Involved in lysine catabolism. {ECO:0000269|PubMed:16491085, ECO:0000269|PubMed:20207735}.
Ensembl transtripts involved in fusion geneENST idsENST00000335698, ENST00000356708, 
ENST00000493053, ENST00000541227, 
ENST00000413020, ENST00000409134, 
ENST00000447989, ENST00000553117, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score10 X 8 X 7=5603 X 3 X 2=18
# samples 113
** MAII scorelog2(11/560*10)=-2.34792330342031
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Fusion gene context

PubMed: ATP5C1 [Title/Abstract] AND ALDH7A1 [Title/Abstract] AND fusion [Title/Abstract]

Fusion neoantigen context

PubMed: ATP5C1 [Title/Abstract] AND ALDH7A1 [Title/Abstract] AND neoantigen [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)ATP5C1(7838118)-ALDH7A1(125896816), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneATP5C1

GO:0042776

mitochondrial ATP synthesis coupled proton transport

12110673



check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:7838118/chr5:125896816)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonRetention analysis results of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features, are available here.

check buttonFusion gene breakpoints across ATP5C1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ALDH7A1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Amino Acid Sequences


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000356708ATP5C1chr107838118+ENST00000409134ALDH7A1chr5125896816-404317079918279
ENST00000356708ATP5C1chr107838118+ENST00000447989ALDH7A1chr5125896816-109617079726215
ENST00000356708ATP5C1chr107838118+ENST00000553117ALDH7A1chr5125896816-109617079726215
ENST00000335698ATP5C1chr107838118+ENST00000409134ALDH7A1chr5125896816-399512231870279
ENST00000335698ATP5C1chr107838118+ENST00000447989ALDH7A1chr5125896816-104812231678215
ENST00000335698ATP5C1chr107838118+ENST00000553117ALDH7A1chr5125896816-104812231678215

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000356708ENST00000409134ATP5C1chr107838118+ALDH7A1chr5125896816-0.000563860.9994361
ENST00000356708ENST00000447989ATP5C1chr107838118+ALDH7A1chr5125896816-0.0034065150.9965934
ENST00000356708ENST00000553117ATP5C1chr107838118+ALDH7A1chr5125896816-0.0034065150.9965934
ENST00000335698ENST00000409134ATP5C1chr107838118+ALDH7A1chr5125896816-0.0005528390.99944717
ENST00000335698ENST00000447989ATP5C1chr107838118+ALDH7A1chr5125896816-0.0033530710.99664694
ENST00000335698ENST00000553117ATP5C1chr107838118+ALDH7A1chr5125896816-0.0033530710.99664694

check button Predicted full-length fusion amino acid sequences. For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among all the predicted ones.

Get the fusion protein sequences from here.

Fusion protein sequence information is available in the fasta format.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

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Fusion Protein Breakpoint Sequences for ATP5C1-ALDH7A1

check button +/-13 AA sequence from the breakpoints of the fusion protein sequences.
HgeneHchrHbpTgeneTchrTbpLength(fusion protein)BP in fusion proteinPeptide
ATP5C1chr107838118ALDH7A1chr512589681612231WIQVRNMATLKDRRSLLELGGNNAII
ATP5C1chr107838118ALDH7A1chr512589681617031WIQVRNMATLKDRRSLLELGGNNAII

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Potential FusionNeoAntigen Information of ATP5C1-ALDH7A1 in HLA I

check button Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.
ATP5C1-ALDH7A1_7838118_125896816.msa

check button Potential FusionNeoAntigen Information
* We used NetMHCpan v4.1 (%rank<0.5) and deepHLApan v1.1 (immunogenic score>0.5)
Fusion geneHchrHbpTgeneTchrTbpHLA IFusionNeoAntigen peptideBinding scoreImmunogenic scoreNeoantigen start (at BP 13)Neoantigen end (at BP 13)
ATP5C1-ALDH7A1chr107838118chr5125896816122HLA-B14:02DRRSLLEL0.99970.89561119
ATP5C1-ALDH7A1chr107838118chr5125896816122HLA-B14:01DRRSLLEL0.99970.89561119
ATP5C1-ALDH7A1chr107838118chr5125896816122HLA-B15:37DRRSLLEL0.9930.57971119
ATP5C1-ALDH7A1chr107838118chr5125896816122HLA-A30:08ATLKDRRSL0.62720.8351716
ATP5C1-ALDH7A1chr107838118chr5125896816122HLA-B08:01TLKDRRSLLEL0.9990.5837819
ATP5C1-ALDH7A1chr107838118chr5125896816122HLA-B39:12DRRSLLEL0.99850.96031119
ATP5C1-ALDH7A1chr107838118chr5125896816122HLA-B14:03DRRSLLEL0.9930.87611119
ATP5C1-ALDH7A1chr107838118chr5125896816122HLA-C15:06ATLKDRRSL0.9890.892716
ATP5C1-ALDH7A1chr107838118chr5125896816122HLA-C03:08ATLKDRRSL0.94860.9472716
ATP5C1-ALDH7A1chr107838118chr5125896816122HLA-C15:05ATLKDRRSL0.98470.8884716
ATP5C1-ALDH7A1chr107838118chr5125896816122HLA-C07:04TLKDRRSLL0.49940.8998817
ATP5C1-ALDH7A1chr107838118chr5125896816122HLA-B48:05KDRRSLLEL0.10190.56041019
ATP5C1-ALDH7A1chr107838118chr5125896816122HLA-B08:18TLKDRRSLLEL0.9990.5837819

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Potential FusionNeoAntigen Information of ATP5C1-ALDH7A1 in HLA II

check button Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.
ATP5C1-ALDH7A1_7838118_125896816.msa

check button Potential FusionNeoAntigen Information
* We used NetMHCIIpan v4.1 (%rank<0.5).
Fusion geneHchrHbpTgeneTchrTbpHLA IIFusionNeoAntigen peptideNeoantigen start (at BP 13)Neoantigen end (at BP 13)
ATP5C1-ALDH7A1chr107838118chr5125896816122DRB1-0403WIQVRNMATLKDRRS015
ATP5C1-ALDH7A1chr107838118chr5125896816122DRB1-0403IQVRNMATLKDRRSL116
ATP5C1-ALDH7A1chr107838118chr5125896816122DRB1-0405WIQVRNMATLKDRRS015
ATP5C1-ALDH7A1chr107838118chr5125896816122DRB1-0409WIQVRNMATLKDRRS015
ATP5C1-ALDH7A1chr107838118chr5125896816122DRB1-0411WIQVRNMATLKDRRS015
ATP5C1-ALDH7A1chr107838118chr5125896816122DRB1-0411IQVRNMATLKDRRSL116
ATP5C1-ALDH7A1chr107838118chr5125896816122DRB1-0415WIQVRNMATLKDRRS015
ATP5C1-ALDH7A1chr107838118chr5125896816122DRB1-0415IQVRNMATLKDRRSL116
ATP5C1-ALDH7A1chr107838118chr5125896816122DRB1-0417WIQVRNMATLKDRRS015
ATP5C1-ALDH7A1chr107838118chr5125896816122DRB1-0424WIQVRNMATLKDRRS015
ATP5C1-ALDH7A1chr107838118chr5125896816122DRB1-0427WIQVRNMATLKDRRS015
ATP5C1-ALDH7A1chr107838118chr5125896816122DRB1-0427IQVRNMATLKDRRSL116
ATP5C1-ALDH7A1chr107838118chr5125896816122DRB1-0429WIQVRNMATLKDRRS015
ATP5C1-ALDH7A1chr107838118chr5125896816122DRB1-0430WIQVRNMATLKDRRS015
ATP5C1-ALDH7A1chr107838118chr5125896816122DRB1-0436WIQVRNMATLKDRRS015
ATP5C1-ALDH7A1chr107838118chr5125896816122DRB1-0436IQVRNMATLKDRRSL116
ATP5C1-ALDH7A1chr107838118chr5125896816122DRB1-0439WIQVRNMATLKDRRS015
ATP5C1-ALDH7A1chr107838118chr5125896816122DRB1-0439IQVRNMATLKDRRSL116
ATP5C1-ALDH7A1chr107838118chr5125896816122DRB1-0440WIQVRNMATLKDRRS015
ATP5C1-ALDH7A1chr107838118chr5125896816122DRB1-0441WIQVRNMATLKDRRS015
ATP5C1-ALDH7A1chr107838118chr5125896816122DRB1-0441IQVRNMATLKDRRSL116
ATP5C1-ALDH7A1chr107838118chr5125896816122DRB1-0442WIQVRNMATLKDRRS015
ATP5C1-ALDH7A1chr107838118chr5125896816122DRB1-0442IQVRNMATLKDRRSL116
ATP5C1-ALDH7A1chr107838118chr5125896816122DRB1-0445WIQVRNMATLKDRRS015
ATP5C1-ALDH7A1chr107838118chr5125896816122DRB1-0446WIQVRNMATLKDRRS015
ATP5C1-ALDH7A1chr107838118chr5125896816122DRB1-0446IQVRNMATLKDRRSL116
ATP5C1-ALDH7A1chr107838118chr5125896816122DRB1-0448WIQVRNMATLKDRRS015
ATP5C1-ALDH7A1chr107838118chr5125896816122DRB1-0449WIQVRNMATLKDRRS015
ATP5C1-ALDH7A1chr107838118chr5125896816122DRB1-0449IQVRNMATLKDRRSL116
ATP5C1-ALDH7A1chr107838118chr5125896816122DRB1-0450WIQVRNMATLKDRRS015
ATP5C1-ALDH7A1chr107838118chr5125896816122DRB1-0450IQVRNMATLKDRRSL116
ATP5C1-ALDH7A1chr107838118chr5125896816122DRB1-0451WIQVRNMATLKDRRS015
ATP5C1-ALDH7A1chr107838118chr5125896816122DRB1-0451IQVRNMATLKDRRSL116
ATP5C1-ALDH7A1chr107838118chr5125896816122DRB1-0452WIQVRNMATLKDRRS015
ATP5C1-ALDH7A1chr107838118chr5125896816122DRB1-0452IQVRNMATLKDRRSL116
ATP5C1-ALDH7A1chr107838118chr5125896816122DRB1-0453WIQVRNMATLKDRRS015
ATP5C1-ALDH7A1chr107838118chr5125896816122DRB1-0453IQVRNMATLKDRRSL116
ATP5C1-ALDH7A1chr107838118chr5125896816122DRB1-0455WIQVRNMATLKDRRS015
ATP5C1-ALDH7A1chr107838118chr5125896816122DRB1-0456WIQVRNMATLKDRRS015
ATP5C1-ALDH7A1chr107838118chr5125896816122DRB1-0457WIQVRNMATLKDRRS015
ATP5C1-ALDH7A1chr107838118chr5125896816122DRB1-0458WIQVRNMATLKDRRS015
ATP5C1-ALDH7A1chr107838118chr5125896816122DRB1-0458IQVRNMATLKDRRSL116
ATP5C1-ALDH7A1chr107838118chr5125896816122DRB1-0459WIQVRNMATLKDRRS015
ATP5C1-ALDH7A1chr107838118chr5125896816122DRB1-0459IQVRNMATLKDRRSL116
ATP5C1-ALDH7A1chr107838118chr5125896816122DRB1-0460WIQVRNMATLKDRRS015
ATP5C1-ALDH7A1chr107838118chr5125896816122DRB1-0460IQVRNMATLKDRRSL116
ATP5C1-ALDH7A1chr107838118chr5125896816122DRB1-0465WIQVRNMATLKDRRS015
ATP5C1-ALDH7A1chr107838118chr5125896816122DRB1-0465IQVRNMATLKDRRSL116
ATP5C1-ALDH7A1chr107838118chr5125896816122DRB1-0467WIQVRNMATLKDRRS015
ATP5C1-ALDH7A1chr107838118chr5125896816122DRB1-0467IQVRNMATLKDRRSL116
ATP5C1-ALDH7A1chr107838118chr5125896816122DRB1-0468WIQVRNMATLKDRRS015
ATP5C1-ALDH7A1chr107838118chr5125896816122DRB1-0470WIQVRNMATLKDRRS015
ATP5C1-ALDH7A1chr107838118chr5125896816122DRB1-0471WIQVRNMATLKDRRS015
ATP5C1-ALDH7A1chr107838118chr5125896816122DRB1-0471IQVRNMATLKDRRSL116
ATP5C1-ALDH7A1chr107838118chr5125896816122DRB1-0473WIQVRNMATLKDRRS015
ATP5C1-ALDH7A1chr107838118chr5125896816122DRB1-0477WIQVRNMATLKDRRS015
ATP5C1-ALDH7A1chr107838118chr5125896816122DRB1-0478WIQVRNMATLKDRRS015
ATP5C1-ALDH7A1chr107838118chr5125896816122DRB1-0479WIQVRNMATLKDRRS015
ATP5C1-ALDH7A1chr107838118chr5125896816122DRB1-0480WIQVRNMATLKDRRS015
ATP5C1-ALDH7A1chr107838118chr5125896816122DRB1-0480IQVRNMATLKDRRSL116
ATP5C1-ALDH7A1chr107838118chr5125896816122DRB1-0483WIQVRNMATLKDRRS015
ATP5C1-ALDH7A1chr107838118chr5125896816122DRB1-0484WIQVRNMATLKDRRS015
ATP5C1-ALDH7A1chr107838118chr5125896816122DRB1-0485WIQVRNMATLKDRRS015
ATP5C1-ALDH7A1chr107838118chr5125896816122DRB1-0485IQVRNMATLKDRRSL116
ATP5C1-ALDH7A1chr107838118chr5125896816122DRB1-0486WIQVRNMATLKDRRS015
ATP5C1-ALDH7A1chr107838118chr5125896816122DRB1-0486IQVRNMATLKDRRSL116
ATP5C1-ALDH7A1chr107838118chr5125896816122DRB1-0487WIQVRNMATLKDRRS015
ATP5C1-ALDH7A1chr107838118chr5125896816122DRB1-0488WIQVRNMATLKDRRS015
ATP5C1-ALDH7A1chr107838118chr5125896816122DRB1-0488IQVRNMATLKDRRSL116
ATP5C1-ALDH7A1chr107838118chr5125896816122DRB1-0489WIQVRNMATLKDRRS015
ATP5C1-ALDH7A1chr107838118chr5125896816122DRB1-0491WIQVRNMATLKDRRS015
ATP5C1-ALDH7A1chr107838118chr5125896816122DRB1-0491IQVRNMATLKDRRSL116
ATP5C1-ALDH7A1chr107838118chr5125896816122DRB1-1410WIQVRNMATLKDRRS015
ATP5C1-ALDH7A1chr107838118chr5125896816122DRB1-1457WIQVRNMATLKDRRS015
ATP5C1-ALDH7A1chr107838118chr5125896816122DRB1-1457IQVRNMATLKDRRSL116

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Fusion breakpoint peptide structures of ATP5C1-ALDH7A1

check button3D structures of the fusion breakpoint peptide of 14AA sequence that have potential fusion neoantigens
* The minimum length of the amino acid sequence in RoseTTAFold is 14AA. Here, we predicted the 14AA fusion protein breakpoint sequence not the fusion neoantigen peptide, which is shorter than 14 AA.
File nameBPseqHgeneTgeneHchrHbpTchrTbpAAlen
5856MATLKDRRSLLELGATP5C1ALDH7A1chr107838118chr5125896816122

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Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D of ATP5C1-ALDH7A1

check buttonVirtual screening between 25 HLAs (from PDB) and FusionNeoAntigens
* We used Glide to predict the interaction between HLAs and neoantigens.
HLA allelePDB IDFile nameBPseqDocking scoreGlide score
HLA-B53:011A1O5856MATLKDRRSLLELG-2.69901-2.81241
HLA-B53:011A1O5856MATLKDRRSLLELG-1.64072-2.67602
HLA-B51:011E285856MATLKDRRSLLELG-3.89938-4.01278
HLA-B51:011E285856MATLKDRRSLLELG-3.06372-4.09902
HLA-B57:032BVO5856MATLKDRRSLLELG-3.85739-3.97079
HLA-B57:032BVO5856MATLKDRRSLLELG-2.16065-3.19595
HLA-A03:012XPG5856MATLKDRRSLLELG-3.98424-4.09764
HLA-A03:012XPG5856MATLKDRRSLLELG-3.8004-4.8357
HLA-B14:023BVN5856MATLKDRRSLLELG-5.50909-5.62249
HLA-B14:023BVN5856MATLKDRRSLLELG-3.39692-4.43222
HLA-B52:013W395856MATLKDRRSLLELG-4.60651-4.71991
HLA-B52:013W395856MATLKDRRSLLELG-3.34519-4.38049
HLA-B18:014JQV5856MATLKDRRSLLELG-4.4543-4.5677
HLA-B18:014JQV5856MATLKDRRSLLELG-3.52041-4.55571
HLA-A11:014UQ25856MATLKDRRSLLELG-8.57217-8.68557
HLA-A11:014UQ25856MATLKDRRSLLELG-5.25237-6.28767
HLA-A24:025HGA5856MATLKDRRSLLELG-5.46268-5.57608
HLA-A24:025HGA5856MATLKDRRSLLELG-4.17359-5.20889
HLA-B57:015VUD5856MATLKDRRSLLELG-3.01236-3.12576
HLA-B57:015VUD5856MATLKDRRSLLELG-2.64732-3.68262
HLA-C08:026JTP5856MATLKDRRSLLELG-5.68918-5.80258
HLA-C08:026JTP5856MATLKDRRSLLELG-2.35623-3.39153
HLA-B37:016MT45856MATLKDRRSLLELG-1.0889-2.1242
HLA-B27:056PYJ5856MATLKDRRSLLELG-3.72452-3.83792
HLA-B27:056PYJ5856MATLKDRRSLLELG-2.83784-3.87314
HLA-B27:036PZ55856MATLKDRRSLLELG-3.01578-3.12918
HLA-B27:036PZ55856MATLKDRRSLLELG-0.24885-1.28415
HLA-B44:053DX85856MATLKDRRSLLELG-4.88127-4.99467
HLA-B44:053DX85856MATLKDRRSLLELG-3.81413-4.84943
HLA-B44:021M6O5856MATLKDRRSLLELG-2.54607-3.58137
HLA-B44:021M6O5856MATLKDRRSLLELG-2.05297-2.16637
HLA-B07:025EO05856MATLKDRRSLLELG-0.497899-1.5332
HLA-A02:016TDR5856MATLKDRRSLLELG-1.85788-2.89318
HLA-A02:016TDR5856MATLKDRRSLLELG-2.64204-2.75544

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Vaccine Design for the FusionNeoAntigens of ATP5C1-ALDH7A1

check button mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-Is.
Fusion geneHchrHbpTchrTbpStart in +/-13AAEnd in +/-13AAFusionNeoAntigen peptide sequenceFusionNeoAntigen RNA sequence
ATP5C1-ALDH7A1chr107838118chr51258968161019KDRRSLLELTGAAAGATAGGAGAAGTCTGTTGGAAC
ATP5C1-ALDH7A1chr107838118chr51258968161119DRRSLLELAAGATAGGAGAAGTCTGTTGGAAC
ATP5C1-ALDH7A1chr107838118chr5125896816716ATLKDRRSLTGGCAACTTTGAAAGATAGGAGAAGTC
ATP5C1-ALDH7A1chr107838118chr5125896816817TLKDRRSLLCAACTTTGAAAGATAGGAGAAGTCTGT
ATP5C1-ALDH7A1chr107838118chr5125896816819TLKDRRSLLELCAACTTTGAAAGATAGGAGAAGTCTGTTGGAAC

check button mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-IIs.
Fusion geneHchrHbpTchrTbpStart in +/-13AAEnd in +/-13AAFusionNeoAntigen peptideFusionNEoAntigen RNA sequence
ATP5C1-ALDH7A1chr107838118chr5125896816015WIQVRNMATLKDRRSAATGGATTCAAGTTCGAAATATGGCAACTTTGAAAGATAGGAGAA
ATP5C1-ALDH7A1chr107838118chr5125896816116IQVRNMATLKDRRSLGGATTCAAGTTCGAAATATGGCAACTTTGAAAGATAGGAGAAGTC

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Information of the samples that have these potential fusion neoantigens of ATP5C1-ALDH7A1

check button These samples were reported as having these fusion breakpoints. For individual breakpoints, we checked the open reading frames considering multiple gene isoforms and chose the in-frame fusion genes only. Then, we made fusion protein sequences and predicted the fusion neoantigens. These fusion-positive samples may have these potential fusion neoantigens.
Cancer typeFusion geneHchrHbpHenstTchrTbpTenstSample
Non-CancerATP5C1-ALDH7A1chr107838118ENST00000335698chr5125896816ENST00000409134ERR315399

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Potential target of CAR-T therapy development for ATP5C1-ALDH7A1

check button Predicted 3D structure. We used RoseTTAFold.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, to provide the retention of the transmembrane domain, we only show the protein feature retention information of those transmembrane features


* Minus value of BPloci means that the break point is located before the CDS.
- In-frame and retained 'Transmembrane'.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

check button Subcellular localization prediction of the transmembrane domain retained fusion proteins
* We used DeepLoc 1.0. The order of the X-axis of the barplot is as follows: Entry_ID, Localization, Type, Nucleus, Cytoplasm, Extracellular, Mitochondrion, Cell_membrane, Endoplasmic_reticulum, Plastid, Golgi.apparatus, Lysosome.Vacuole, Peroxisome. Y-axis is the output score of DeepLoc. Clicking the image will open a new tab with a large image.
HgeneHchrHbpHenstTgeneTchrTbpTenstDeepLoc result

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Related Drugs to ATP5C1-ALDH7A1

check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to ATP5C1-ALDH7A1

check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource