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Center for Computational Systems Medicine
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Fusion Gene and Fusion Protein Summary

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Fusion Amino Acid Sequences (multiple BPs and multiple gene isoforms)

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Fusion Protein Breakpoint Sequences - (for the Screening of the FusionNeoAntigens)

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Potential FusionNeoAntigens in HLA I - (netMHCpan v4.1 + deepHLApan v1.1)

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Potential FusionNeoAntigens in HLA II - (netMHCIIpan v4.1)

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Fusion Breakpoint 14 AA Peptide Structure - (RoseTTAFold)

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Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D - (Glide)

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Vaccine Design for the FusionNeoAntigens (RNA/protein sequences)

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Potential target of CAR-T therapy development

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Information on the samples that have these potential fusion neoantigens

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Fusion Protein Targeting Drugs - (Manual Curation)

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Fusion Protein Related diseases - (Manual Curation)

Fusion Protein:SH3D19-FUS

Fusion Gene and Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: SH3D19-FUS
FusionPDB ID: 81430
FusionGDB2.0 ID: 81430
HgeneTgene
Gene symbol

SH3D19

FUS

Gene ID

152503

2521

Gene nameSH3 domain containing 19FUS RNA binding protein
SynonymsEBP|EVE1|Eve-1|Kryn|SH3P19ALS6|ETM4|FUS1|HNRNPP2|POMP75|TLS
Cytomap

4q31.3

16p11.2

Type of geneprotein-codingprotein-coding
DescriptionSH3 domain-containing protein 19ADAM-binding protein Eve-1EEN-binding proteinSH3 domain protein D19RNA-binding protein FUS75 kDa DNA-pairing proteinfus-like proteinfused in sarcomafusion gene in myxoid liposarcomaheterogeneous nuclear ribonucleoprotein P2oncogene FUSoncogene TLStranslocated in liposarcoma protein
Modification date2020031320200329
UniProtAcc.

P35637

Main function of 5'-partner protein: FUNCTION: DNA/RNA-binding protein that plays a role in various cellular processes such as transcription regulation, RNA splicing, RNA transport, DNA repair and damage response (PubMed:27731383). Binds to nascent pre-mRNAs and acts as a molecular mediator between RNA polymerase II and U1 small nuclear ribonucleoprotein thereby coupling transcription and splicing (PubMed:26124092). Binds also its own pre-mRNA and autoregulates its expression; this autoregulation mechanism is mediated by non-sense-mediated decay (PubMed:24204307). Plays a role in DNA repair mechanisms by promoting D-loop formation and homologous recombination during DNA double-strand break repair (PubMed:10567410). In neuronal cells, plays crucial roles in dendritic spine formation and stability, RNA transport, mRNA stability and synaptic homeostasis (By similarity). {ECO:0000250|UniProtKB:P56959, ECO:0000269|PubMed:10567410, ECO:0000269|PubMed:24204307, ECO:0000269|PubMed:26124092, ECO:0000269|PubMed:27731383}.
Ensembl transtripts involved in fusion geneENST idsENST00000304527, ENST00000409252, 
ENST00000409598, ENST00000424281, 
ENST00000427414, ENST00000455740, 
ENST00000514152, ENST00000604030, 
ENST00000474990, ENST00000254108, 
ENST00000380244, ENST00000568685, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score13 X 9 X 6=70220 X 13 X 10=2600
# samples 1422
** MAII scorelog2(14/702*10)=-2.32604420335959
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(22/2600*10)=-3.56293619439116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Fusion gene context

PubMed: SH3D19 [Title/Abstract] AND FUS [Title/Abstract] AND fusion [Title/Abstract]

Fusion neoantigen context

PubMed: SH3D19 [Title/Abstract] AND FUS [Title/Abstract] AND neoantigen [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)SH3D19(152095821)-FUS(31199645), # samples:1
SH3D19(152095822)-FUS(31199646), # samples:1
Anticipated loss of major functional domain due to fusion event.SH3D19-FUS seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
SH3D19-FUS seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
SH3D19-FUS seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
SH3D19-FUS seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
SH3D19-FUS seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
SH3D19-FUS seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
SH3D19-FUS seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneFUS

GO:0006355

regulation of transcription, DNA-templated

26124092

TgeneFUS

GO:0006357

regulation of transcription by RNA polymerase II

25453086

TgeneFUS

GO:0008380

RNA splicing

26124092

TgeneFUS

GO:0043484

regulation of RNA splicing

25453086|27731383

TgeneFUS

GO:0048255

mRNA stabilization

27378374

TgeneFUS

GO:0051260

protein homooligomerization

25453086

TgeneFUS

GO:1905168

positive regulation of double-strand break repair via homologous recombination

10567410



check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr4:152095821/chr16:31199645)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonRetention analysis results of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features, are available here.

check buttonFusion gene breakpoints across SH3D19 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across FUS (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Amino Acid Sequences


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000409598SH3D19chr4152095821-ENST00000254108FUSchr1631199645+301218624812643720
ENST00000409598SH3D19chr4152095821-ENST00000380244FUSchr1631199645+280818624812643720
ENST00000409598SH3D19chr4152095821-ENST00000568685FUSchr1631199645+278418624812646721
ENST00000424281SH3D19chr4152095821-ENST00000254108FUSchr1631199645+293417843912565724
ENST00000424281SH3D19chr4152095821-ENST00000380244FUSchr1631199645+273017843912565724
ENST00000424281SH3D19chr4152095821-ENST00000568685FUSchr1631199645+270617843912568725
ENST00000304527SH3D19chr4152095821-ENST00000254108FUSchr1631199645+293417843912565724
ENST00000304527SH3D19chr4152095821-ENST00000380244FUSchr1631199645+273017843912565724
ENST00000304527SH3D19chr4152095821-ENST00000568685FUSchr1631199645+270617843912568725
ENST00000455740SH3D19chr4152095821-ENST00000254108FUSchr1631199645+293417843912565724
ENST00000455740SH3D19chr4152095821-ENST00000380244FUSchr1631199645+273017843912565724
ENST00000455740SH3D19chr4152095821-ENST00000568685FUSchr1631199645+270617843912568725
ENST00000409252SH3D19chr4152095821-ENST00000254108FUSchr1631199645+25521402302183717
ENST00000409252SH3D19chr4152095821-ENST00000380244FUSchr1631199645+23481402302183717
ENST00000409252SH3D19chr4152095821-ENST00000568685FUSchr1631199645+23241402302186718
ENST00000409598SH3D19chr4152095822-ENST00000254108FUSchr1631199646+301218624812643720
ENST00000409598SH3D19chr4152095822-ENST00000380244FUSchr1631199646+280818624812643720
ENST00000409598SH3D19chr4152095822-ENST00000568685FUSchr1631199646+278418624812646721
ENST00000424281SH3D19chr4152095822-ENST00000254108FUSchr1631199646+293417843912565724
ENST00000424281SH3D19chr4152095822-ENST00000380244FUSchr1631199646+273017843912565724
ENST00000424281SH3D19chr4152095822-ENST00000568685FUSchr1631199646+270617843912568725
ENST00000304527SH3D19chr4152095822-ENST00000254108FUSchr1631199646+293417843912565724
ENST00000304527SH3D19chr4152095822-ENST00000380244FUSchr1631199646+273017843912565724
ENST00000304527SH3D19chr4152095822-ENST00000568685FUSchr1631199646+270617843912568725
ENST00000455740SH3D19chr4152095822-ENST00000254108FUSchr1631199646+293417843912565724
ENST00000455740SH3D19chr4152095822-ENST00000380244FUSchr1631199646+273017843912565724
ENST00000455740SH3D19chr4152095822-ENST00000568685FUSchr1631199646+270617843912568725
ENST00000409252SH3D19chr4152095822-ENST00000254108FUSchr1631199646+25521402302183717
ENST00000409252SH3D19chr4152095822-ENST00000380244FUSchr1631199646+23481402302183717
ENST00000409252SH3D19chr4152095822-ENST00000568685FUSchr1631199646+23241402302186718

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000409598ENST00000254108SH3D19chr4152095821-FUSchr1631199645+0.0014684120.9985316
ENST00000409598ENST00000380244SH3D19chr4152095821-FUSchr1631199645+0.0016583610.9983417
ENST00000409598ENST00000568685SH3D19chr4152095821-FUSchr1631199645+0.0022767520.9977233
ENST00000424281ENST00000254108SH3D19chr4152095821-FUSchr1631199645+0.0015445640.9984554
ENST00000424281ENST00000380244SH3D19chr4152095821-FUSchr1631199645+0.0017467640.99825317
ENST00000424281ENST00000568685SH3D19chr4152095821-FUSchr1631199645+0.002390020.99761
ENST00000304527ENST00000254108SH3D19chr4152095821-FUSchr1631199645+0.0015445640.9984554
ENST00000304527ENST00000380244SH3D19chr4152095821-FUSchr1631199645+0.0017467640.99825317
ENST00000304527ENST00000568685SH3D19chr4152095821-FUSchr1631199645+0.002390020.99761
ENST00000455740ENST00000254108SH3D19chr4152095821-FUSchr1631199645+0.0015445640.9984554
ENST00000455740ENST00000380244SH3D19chr4152095821-FUSchr1631199645+0.0017467640.99825317
ENST00000455740ENST00000568685SH3D19chr4152095821-FUSchr1631199645+0.002390020.99761
ENST00000409252ENST00000254108SH3D19chr4152095821-FUSchr1631199645+0.0020070550.997993
ENST00000409252ENST00000380244SH3D19chr4152095821-FUSchr1631199645+0.0023368890.99766314
ENST00000409252ENST00000568685SH3D19chr4152095821-FUSchr1631199645+0.0032022290.99679774
ENST00000409598ENST00000254108SH3D19chr4152095822-FUSchr1631199646+0.0014684120.9985316
ENST00000409598ENST00000380244SH3D19chr4152095822-FUSchr1631199646+0.0016583610.9983417
ENST00000409598ENST00000568685SH3D19chr4152095822-FUSchr1631199646+0.0022767520.9977233
ENST00000424281ENST00000254108SH3D19chr4152095822-FUSchr1631199646+0.0015445640.9984554
ENST00000424281ENST00000380244SH3D19chr4152095822-FUSchr1631199646+0.0017467640.99825317
ENST00000424281ENST00000568685SH3D19chr4152095822-FUSchr1631199646+0.002390020.99761
ENST00000304527ENST00000254108SH3D19chr4152095822-FUSchr1631199646+0.0015445640.9984554
ENST00000304527ENST00000380244SH3D19chr4152095822-FUSchr1631199646+0.0017467640.99825317
ENST00000304527ENST00000568685SH3D19chr4152095822-FUSchr1631199646+0.002390020.99761
ENST00000455740ENST00000254108SH3D19chr4152095822-FUSchr1631199646+0.0015445640.9984554
ENST00000455740ENST00000380244SH3D19chr4152095822-FUSchr1631199646+0.0017467640.99825317
ENST00000455740ENST00000568685SH3D19chr4152095822-FUSchr1631199646+0.002390020.99761
ENST00000409252ENST00000254108SH3D19chr4152095822-FUSchr1631199646+0.0020070550.997993
ENST00000409252ENST00000380244SH3D19chr4152095822-FUSchr1631199646+0.0023368890.99766314
ENST00000409252ENST00000568685SH3D19chr4152095822-FUSchr1631199646+0.0032022290.99679774

check button Predicted full-length fusion amino acid sequences. For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among all the predicted ones.

Get the fusion protein sequences from here.

Fusion protein sequence information is available in the fasta format.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

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Fusion Protein Breakpoint Sequences for SH3D19-FUS

check button +/-13 AA sequence from the breakpoints of the fusion protein sequences.
HgeneHchrHbpTgeneTchrTbpLength(fusion protein)BP in fusion proteinPeptide
SH3D19chr4152095821FUSchr16311996451402457NLAEESVGSEMVLGPRDQGSRHDSAE
SH3D19chr4152095821FUSchr16311996451402457NLAEESVGSEMVLGPRDQGSRHDSEQ
SH3D19chr4152095821FUSchr16311996451402572ATRRADFNRGGGNGRGGRGRGGPMGR
SH3D19chr4152095821FUSchr16311996451402573ATRRADFNRGGGNGRGGRGRGGPMGR
SH3D19chr4152095821FUSchr16311996451402573TRRADFNRGGGNGRGGRGRGGPMGRG
SH3D19chr4152095821FUSchr16311996451402574TRRADFNRGGGNGRGGRGRGGPMGRG
SH3D19chr4152095821FUSchr16311996451784464NLAEESVGSEMVLGPRDQGSRHDSAE
SH3D19chr4152095821FUSchr16311996451784464NLAEESVGSEMVLGPRDQGSRHDSEQ
SH3D19chr4152095821FUSchr16311996451784579ATRRADFNRGGGNGRGGRGRGGPMGR
SH3D19chr4152095821FUSchr16311996451784580ATRRADFNRGGGNGRGGRGRGGPMGR
SH3D19chr4152095821FUSchr16311996451784580TRRADFNRGGGNGRGGRGRGGPMGRG
SH3D19chr4152095821FUSchr16311996451784581TRRADFNRGGGNGRGGRGRGGPMGRG
SH3D19chr4152095821FUSchr16311996451862460NLAEESVGSEMVLGPRDQGSRHDSAE
SH3D19chr4152095821FUSchr16311996451862460NLAEESVGSEMVLGPRDQGSRHDSEQ
SH3D19chr4152095821FUSchr16311996451862575ATRRADFNRGGGNGRGGRGRGGPMGR
SH3D19chr4152095821FUSchr16311996451862576ATRRADFNRGGGNGRGGRGRGGPMGR
SH3D19chr4152095821FUSchr16311996451862576TRRADFNRGGGNGRGGRGRGGPMGRG
SH3D19chr4152095821FUSchr16311996451862577TRRADFNRGGGNGRGGRGRGGPMGRG
SH3D19chr4152095822FUSchr16311996461402457NLAEESVGSEMVLGPRDQGSRHDSAE
SH3D19chr4152095822FUSchr16311996461402457NLAEESVGSEMVLGPRDQGSRHDSEQ
SH3D19chr4152095822FUSchr16311996461402572ATRRADFNRGGGNGRGGRGRGGPMGR
SH3D19chr4152095822FUSchr16311996461402573ATRRADFNRGGGNGRGGRGRGGPMGR
SH3D19chr4152095822FUSchr16311996461402573TRRADFNRGGGNGRGGRGRGGPMGRG
SH3D19chr4152095822FUSchr16311996461402574TRRADFNRGGGNGRGGRGRGGPMGRG
SH3D19chr4152095822FUSchr16311996461784464NLAEESVGSEMVLGPRDQGSRHDSAE
SH3D19chr4152095822FUSchr16311996461784464NLAEESVGSEMVLGPRDQGSRHDSEQ
SH3D19chr4152095822FUSchr16311996461784579ATRRADFNRGGGNGRGGRGRGGPMGR
SH3D19chr4152095822FUSchr16311996461784580ATRRADFNRGGGNGRGGRGRGGPMGR
SH3D19chr4152095822FUSchr16311996461784580TRRADFNRGGGNGRGGRGRGGPMGRG
SH3D19chr4152095822FUSchr16311996461784581TRRADFNRGGGNGRGGRGRGGPMGRG
SH3D19chr4152095822FUSchr16311996461862460NLAEESVGSEMVLGPRDQGSRHDSAE
SH3D19chr4152095822FUSchr16311996461862460NLAEESVGSEMVLGPRDQGSRHDSEQ
SH3D19chr4152095822FUSchr16311996461862575ATRRADFNRGGGNGRGGRGRGGPMGR
SH3D19chr4152095822FUSchr16311996461862576ATRRADFNRGGGNGRGGRGRGGPMGR
SH3D19chr4152095822FUSchr16311996461862576TRRADFNRGGGNGRGGRGRGGPMGRG
SH3D19chr4152095822FUSchr16311996461862577TRRADFNRGGGNGRGGRGRGGPMGRG

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Potential FusionNeoAntigen Information of SH3D19-FUS in HLA I

check button Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.

check button Potential FusionNeoAntigen Information
* We used NetMHCpan v4.1 (%rank<0.5) and deepHLApan v1.1 (immunogenic score>0.5)
Fusion geneHchrHbpTgeneTchrTbpHLA IFusionNeoAntigen peptideBinding scoreImmunogenic scoreNeoantigen start (at BP 13)Neoantigen end (at BP 13)

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Potential FusionNeoAntigen Information of SH3D19-FUS in HLA II

check button Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.

check button Potential FusionNeoAntigen Information
* We used NetMHCIIpan v4.1 (%rank<0.5).
Fusion geneHchrHbpTgeneTchrTbpHLA IIFusionNeoAntigen peptideNeoantigen start (at BP 13)Neoantigen end (at BP 13)

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Fusion breakpoint peptide structures of SH3D19-FUS

check button3D structures of the fusion breakpoint peptide of 14AA sequence that have potential fusion neoantigens
* The minimum length of the amino acid sequence in RoseTTAFold is 14AA. Here, we predicted the 14AA fusion protein breakpoint sequence not the fusion neoantigen peptide, which is shorter than 14 AA.

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Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D of SH3D19-FUS

check buttonVirtual screening between 25 HLAs (from PDB) and FusionNeoAntigens
* We used Glide to predict the interaction between HLAs and neoantigens.
HLA allelePDB IDFile nameBPseqDocking scoreGlide score

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Vaccine Design for the FusionNeoAntigens of SH3D19-FUS

check button mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-Is.
Fusion geneHchrHbpTchrTbpStart in +/-13AAEnd in +/-13AAFusionNeoAntigen peptide sequenceFusionNeoAntigen RNA sequence

check button mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-IIs.
Fusion geneHchrHbpTchrTbpStart in +/-13AAEnd in +/-13AAFusionNeoAntigen peptideFusionNEoAntigen RNA sequence

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Information of the samples that have these potential fusion neoantigens of SH3D19-FUS

check button These samples were reported as having these fusion breakpoints. For individual breakpoints, we checked the open reading frames considering multiple gene isoforms and chose the in-frame fusion genes only. Then, we made fusion protein sequences and predicted the fusion neoantigens. These fusion-positive samples may have these potential fusion neoantigens.
Cancer typeFusion geneHchrHbpHenstTchrTbpTenstSample

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Potential target of CAR-T therapy development for SH3D19-FUS

check button Predicted 3D structure. We used RoseTTAFold.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, to provide the retention of the transmembrane domain, we only show the protein feature retention information of those transmembrane features


* Minus value of BPloci means that the break point is located before the CDS.
- In-frame and retained 'Transmembrane'.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

check button Subcellular localization prediction of the transmembrane domain retained fusion proteins
* We used DeepLoc 1.0. The order of the X-axis of the barplot is as follows: Entry_ID, Localization, Type, Nucleus, Cytoplasm, Extracellular, Mitochondrion, Cell_membrane, Endoplasmic_reticulum, Plastid, Golgi.apparatus, Lysosome.Vacuole, Peroxisome. Y-axis is the output score of DeepLoc. Clicking the image will open a new tab with a large image.
HgeneHchrHbpHenstTgeneTchrTbpTenstDeepLoc result

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Related Drugs to SH3D19-FUS

check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to SH3D19-FUS

check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneFUSC1842675AMYOTROPHIC LATERAL SCLEROSIS 6 (disorder)5UNIPROT
TgeneFUSC3468114Juvenile amyotrophic lateral sclerosis5ORPHANET
TgeneFUSC0002736Amyotrophic Lateral Sclerosis2CTD_human;ORPHANET
TgeneFUSC0206634Liposarcoma, Myxoid2CTD_human;ORPHANET
TgeneFUSC0393554Amyotrophic Lateral Sclerosis With Dementia1CTD_human
TgeneFUSC0497327Dementia1GENOMICS_ENGLAND
TgeneFUSC0543859Amyotrophic Lateral Sclerosis, Guam Form1CTD_human
TgeneFUSC3539195TREMOR, HEREDITARY ESSENTIAL, 41CTD_human;UNIPROT
TgeneFUSC3888102Frontotemporal Dementia With Motor Neuron Disease1ORPHANET