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Fusion Protein:SLC25A16-DRGX

Fusion Gene and Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: SLC25A16-DRGX
	FusionPDB ID: 82571
	FusionGDB2.0 ID: 82571
		Hgene	Tgene
	Gene symbol	SLC25A16	DRGX
	Gene ID	8034	644168
	Gene name	solute carrier family 25 member 16	dorsal root ganglia homeobox
	Synonyms	D10S105E\|GDA\|GDC\|HGT.1\|ML7\|hML7	DRG11\|PRRXL1
	Cytomap	10q21.3	10q11.23
	Type of gene	protein-coding	protein-coding
	Description	graves disease carrier proteinmitochondrial solute carrier protein homologsolute carrier family 25 (mitochondrial carrier; Graves disease autoantigen), member 16	dorsal root ganglia homeobox proteinpaired related homeobox-like 1paired-like homeodomain trancription factor DRG11
	Modification date	20200313	20200313
	UniProtAcc	P16260 Main function of 5'-partner protein: FUNCTION: Required for the accumulation of coenzyme A in the mitochondrial matrix. {ECO:0000269\|PubMed:11158296}.	.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000265870, ENST00000539557, ENST00000609923,	ENST00000374139, ENST00000434016,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	7 X 7 X 3=147	2 X 2 X 2=8
	# samples	7	2
	** MAII score	log2(7/147*10)=-1.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(2/8*10)=1.32192809488736
Fusion gene context	PubMed: SLC25A16 [Title/Abstract] AND DRGX [Title/Abstract] AND fusion [Title/Abstract]
Fusion neoantigen context	PubMed: SLC25A16 [Title/Abstract] AND DRGX [Title/Abstract] AND neoantigen [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	SLC25A16(70248224)-DRGX(50574426), # samples:3
Anticipated loss of major functional domain due to fusion event.	SLC25A16-DRGX seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. SLC25A16-DRGX seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. SLC25A16-DRGX seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. SLC25A16-DRGX seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. SLC25A16-DRGX seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF. SLC25A16-DRGX seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. SLC25A16-DRGX seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF. SLC25A16-DRGX seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:70248224/chr10:50574426)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Retention analysis results of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features, are available here.

Fusion gene breakpoints across SLC25A16 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across DRGX (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Amino Acid Sequences

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000609923	SLC25A16	chr10	70248224	-	ENST00000434016	DRGX	chr10	50574426	-	1138	872	90	947	285
ENST00000539557	SLC25A16	chr10	70248224	-	ENST00000374139	DRGX	chr10	50574426	-	3186	996	391	1071	226

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000609923	ENST00000434016	SLC25A16	chr10	70248224	-	DRGX	chr10	50574426	-	0.009027694	0.9909723
ENST00000539557	ENST00000374139	SLC25A16	chr10	70248224	-	DRGX	chr10	50574426	-	0.011301494	0.98869854

Predicted full-length fusion amino acid sequences. For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among all the predicted ones.

Get the fusion protein sequences from here.

Fusion protein sequence information is available in the fasta format.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

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Fusion Protein Breakpoint Sequences for SLC25A16-DRGX

+/-13 AA sequence from the breakpoints of the fusion protein sequences.

Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	Length(fusion protein)	BP in fusion protein	Peptide
SLC25A16	chr10	70248224	DRGX	chr10	50574426	872	261	CGGVAGAIAQTISGPTVLLLRPRPHG
SLC25A16	chr10	70248224	DRGX	chr10	50574426	996	202	CGGVAGAIAQTISGPTVLLLRPRPHG

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Potential FusionNeoAntigen Information of SLC25A16-DRGX in HLA I

Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.

SLC25A16-DRGX_70248224_50574426.msa

Potential FusionNeoAntigen Information
* We used NetMHCpan v4.1 (%rank<0.5) and deepHLApan v1.1 (immunogenic score>0.5)

Fusion gene	Hchr	Hbp	Tgene	Tchr	Tbp	HLA I	FusionNeoAntigen peptide	Binding score	Immunogenic score	Neoantigen start (at BP 13)	Neoantigen end (at BP 13)
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	HLA-B15:17	ISGPTVLLL	0.989	0.849	11	20
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	HLA-B15:16	ISGPTVLLL	0.986	0.6828	11	20
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	HLA-B58:01	ISGPTVLLL	0.9838	0.8854	11	20
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	HLA-B57:03	ISGPTVLLL	0.9681	0.9659	11	20
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	HLA-B15:17	QTISGPTVL	0.9574	0.9497	9	18
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	HLA-B58:02	ISGPTVLLL	0.9573	0.8906	11	20
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	HLA-B15:16	QTISGPTVL	0.9313	0.9588	9	18
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	HLA-A02:38	TISGPTVLL	0.9295	0.6682	10	19
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	HLA-B48:01	AQTISGPTV	0.9181	0.8083	8	17
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	HLA-B13:02	AQTISGPTV	0.8683	0.8932	8	17
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	HLA-B52:01	ISGPTVLLL	0.8283	0.7806	11	20
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	HLA-B13:01	AQTISGPTV	0.6554	0.9822	8	17
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	HLA-B39:13	AQTISGPTV	0.4124	0.9392	8	17
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	HLA-B52:01	AQTISGPTV	0.0315	0.9785	8	17
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	HLA-B15:01	AQTISGPTVL	0.9935	0.8982	8	18
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	HLA-B48:01	AQTISGPTVL	0.945	0.9225	8	18
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	HLA-B15:03	AQTISGPTVL	0.9091	0.826	8	18
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	HLA-B39:13	AQTISGPTVL	0.7926	0.9758	8	18
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	HLA-B13:01	AQTISGPTVL	0.6914	0.9816	8	18
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	HLA-B13:02	AQTISGPTVL	0.6858	0.8561	8	18
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	HLA-B48:01	AQTISGPTVLL	0.995	0.9393	8	19
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	HLA-B13:01	AQTISGPTVLL	0.9795	0.9865	8	19
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	HLA-C15:06	ISGPTVLL	0.9999	0.9149	11	19
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	HLA-C01:17	SGPTVLLL	0.9983	0.9429	12	20
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	HLA-C01:30	SGPTVLLL	0.9971	0.9515	12	20
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	HLA-C15:04	ISGPTVLLL	0.9994	0.9069	11	20
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	HLA-C03:07	ISGPTVLLL	0.9993	0.9608	11	20
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	HLA-C15:06	ISGPTVLLL	0.9992	0.9145	11	20
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	HLA-C03:19	QTISGPTVL	0.9991	0.9884	9	18
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	HLA-C03:19	ISGPTVLLL	0.999	0.9872	11	20
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	HLA-C03:08	ISGPTVLLL	0.999	0.891	11	20
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	HLA-C03:08	QTISGPTVL	0.9989	0.9259	9	18
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	HLA-C03:07	QTISGPTVL	0.9987	0.9821	9	18
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	HLA-C15:06	QTISGPTVL	0.9982	0.9501	9	18
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	HLA-C15:04	QTISGPTVL	0.9981	0.9383	9	18
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	HLA-C03:19	TISGPTVLL	0.998	0.9923	10	19
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	HLA-C03:07	TISGPTVLL	0.9978	0.9831	10	19
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	HLA-C03:08	TISGPTVLL	0.9974	0.9014	10	19
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	HLA-C15:06	TISGPTVLL	0.9967	0.9105	10	19
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	HLA-C01:17	ISGPTVLLL	0.9966	0.9521	11	20
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	HLA-C04:06	ISGPTVLLL	0.9955	0.9231	11	20
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	HLA-C04:06	TISGPTVLL	0.9923	0.9502	10	19
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	HLA-C04:06	QTISGPTVL	0.9885	0.9723	9	18
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	HLA-C08:04	TISGPTVLL	0.9833	0.9832	10	19
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	HLA-C08:13	TISGPTVLL	0.9833	0.9832	10	19
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	HLA-C12:12	QTISGPTVL	0.9797	0.9526	9	18
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	HLA-C08:04	QTISGPTVL	0.9747	0.9811	9	18
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	HLA-C08:13	QTISGPTVL	0.9747	0.9811	9	18
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	HLA-C08:04	ISGPTVLLL	0.9731	0.962	11	20
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	HLA-C08:13	ISGPTVLLL	0.9731	0.962	11	20
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	HLA-C06:03	QTISGPTVL	0.967	0.9927	9	18
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	HLA-C12:04	QTISGPTVL	0.9664	0.9909	9	18
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	HLA-C01:17	TISGPTVLL	0.9597	0.9628	10	19
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	HLA-C06:03	ISGPTVLLL	0.9489	0.99	11	20
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	HLA-C12:12	ISGPTVLLL	0.9482	0.9468	11	20
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	HLA-C12:04	ISGPTVLLL	0.9434	0.9894	11	20
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	HLA-C01:17	QTISGPTVL	0.9431	0.9692	9	18
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	HLA-C08:03	QTISGPTVL	0.8828	0.9901	9	18
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	HLA-C01:30	TISGPTVLL	0.8543	0.9642	10	19
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	HLA-C02:06	TISGPTVLL	0.828	0.9443	10	19
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	HLA-C08:03	TISGPTVLL	0.8135	0.9883	10	19
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	HLA-C03:14	QTISGPTVL	0.7879	0.979	9	18
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	HLA-C02:06	QTISGPTVL	0.7446	0.9742	9	18
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	HLA-C08:03	ISGPTVLLL	0.7078	0.9808	11	20
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	HLA-B48:03	AQTISGPTV	0.6713	0.7593	8	17
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	HLA-C01:30	QTISGPTVL	0.6118	0.9661	9	18
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	HLA-C02:06	ISGPTVLLL	0.552	0.9451	11	20
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	HLA-B39:08	AQTISGPTV	0.5096	0.7765	8	17
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	HLA-B15:04	AQTISGPTVL	0.9858	0.9453	8	18
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	HLA-B39:08	AQTISGPTVL	0.8547	0.9512	8	18
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	HLA-B48:03	AQTISGPTVL	0.8368	0.8109	8	18
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	HLA-C03:19	IAQTISGPTVL	0.9995	0.9922	7	18
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	HLA-C03:08	IAQTISGPTVL	0.999	0.8779	7	18
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	HLA-B48:03	AQTISGPTVLL	0.9537	0.8882	8	19
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	HLA-C15:05	ISGPTVLL	0.9999	0.8855	11	19
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	HLA-C15:02	ISGPTVLL	0.9999	0.8811	11	19
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	HLA-C01:03	SGPTVLLL	0.9994	0.9451	12	20
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	HLA-C01:02	SGPTVLLL	0.9987	0.9372	12	20
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	HLA-C15:09	ISGPTVLLL	0.9994	0.9069	11	20
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	HLA-C04:03	ISGPTVLLL	0.9993	0.8925	11	20
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	HLA-C15:05	ISGPTVLLL	0.9991	0.8667	11	20
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	HLA-C15:02	ISGPTVLLL	0.9991	0.8684	11	20
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	HLA-C03:03	QTISGPTVL	0.999	0.9837	9	18
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	HLA-C03:04	QTISGPTVL	0.999	0.9837	9	18
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	HLA-C03:03	ISGPTVLLL	0.9989	0.9819	11	20
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	HLA-C03:04	ISGPTVLLL	0.9989	0.9819	11	20
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	HLA-C03:17	ISGPTVLLL	0.9988	0.9552	11	20
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	HLA-C03:05	ISGPTVLLL	0.9987	0.9057	11	20
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	HLA-C15:09	QTISGPTVL	0.9981	0.9383	9	18
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	HLA-C15:05	QTISGPTVL	0.998	0.963	9	18
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	HLA-C15:02	QTISGPTVL	0.9979	0.9451	9	18
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	HLA-C03:05	QTISGPTVL	0.9979	0.9282	9	18
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	HLA-C03:17	QTISGPTVL	0.9979	0.9733	9	18
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	HLA-C03:03	TISGPTVLL	0.9975	0.9893	10	19
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	HLA-C03:04	TISGPTVLL	0.9975	0.9893	10	19
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	HLA-C01:03	ISGPTVLLL	0.9974	0.961	11	20
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	HLA-C04:03	TISGPTVLL	0.9966	0.9147	10	19
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	HLA-C03:67	QTISGPTVL	0.9964	0.9776	9	18
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	HLA-C15:05	TISGPTVLL	0.9957	0.9191	10	19
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	HLA-C15:02	TISGPTVLL	0.9956	0.8988	10	19
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	HLA-C03:02	QTISGPTVL	0.9948	0.9768	9	18
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	HLA-C03:05	TISGPTVLL	0.9935	0.9256	10	19
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	HLA-C04:04	TISGPTVLL	0.9919	0.9501	10	19
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	HLA-B57:04	ISGPTVLLL	0.9888	0.6427	11	20
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	HLA-C03:06	ISGPTVLLL	0.9868	0.9823	11	20
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	HLA-C12:03	QTISGPTVL	0.9864	0.9815	9	18
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	HLA-C01:03	TISGPTVLL	0.9812	0.9599	10	19
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	HLA-C03:06	QTISGPTVL	0.9809	0.9865	9	18
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	HLA-B58:06	ISGPTVLLL	0.9751	0.7345	11	20
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	HLA-C16:04	QTISGPTVL	0.9749	0.9811	9	18
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	HLA-C01:02	TISGPTVLL	0.9735	0.9608	10	19
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	HLA-C16:02	ISGPTVLLL	0.9715	0.9899	11	20
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	HLA-C12:02	QTISGPTVL	0.9705	0.9741	9	18
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	HLA-B57:02	ISGPTVLLL	0.9682	0.8362	11	20
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	HLA-C16:04	ISGPTVLLL	0.9667	0.9782	11	20
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	HLA-C03:06	TISGPTVLL	0.9638	0.9885	10	19
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	HLA-C01:02	QTISGPTVL	0.948	0.9678	9	18
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	HLA-C12:03	ISGPTVLLL	0.9454	0.9779	11	20
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	HLA-C16:01	ISGPTVLLL	0.9296	0.9778	11	20
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	HLA-A68:02	QTISGPTVL	0.9264	0.5823	9	18
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	HLA-C16:01	QTISGPTVL	0.9244	0.9775	9	18
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	HLA-C16:02	QTISGPTVL	0.8881	0.9921	9	18
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	HLA-B15:73	QTISGPTVL	0.888	0.9651	9	18
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	HLA-C08:01	QTISGPTVL	0.8828	0.9901	9	18
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	HLA-A69:01	TISGPTVLL	0.8581	0.5469	10	19
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	HLA-B35:13	QTISGPTVL	0.8241	0.8729	9	18
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	HLA-B15:30	QTISGPTVL	0.8184	0.9086	9	18
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	HLA-B15:73	TISGPTVLL	0.8139	0.9616	10	19
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	HLA-C08:01	TISGPTVLL	0.8135	0.9883	10	19
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	HLA-A69:01	QTISGPTVL	0.8058	0.62	9	18
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	HLA-B35:13	ISGPTVLLL	0.8034	0.8425	11	20
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	HLA-B15:30	TISGPTVLL	0.7532	0.8611	10	19
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	HLA-C02:02	QTISGPTVL	0.7313	0.9825	9	18
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	HLA-C02:10	QTISGPTVL	0.7313	0.9825	9	18
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	HLA-C08:01	ISGPTVLLL	0.7078	0.9808	11	20
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	HLA-B07:13	QTISGPTVL	0.689	0.8431	9	18
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	HLA-B15:73	AQTISGPTV	0.6761	0.9652	8	17
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	HLA-B40:12	AQTISGPTV	0.6713	0.7593	8	17
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	HLA-C17:01	ISGPTVLLL	0.625	0.9313	11	20
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	HLA-B15:30	AQTISGPTV	0.5546	0.9177	8	17
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	HLA-C17:01	TISGPTVLL	0.5449	0.9403	10	19
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	HLA-C02:10	ISGPTVLLL	0.5394	0.9544	11	20
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	HLA-C02:02	ISGPTVLLL	0.5394	0.9544	11	20
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	HLA-B40:49	AQTISGPTV	0.5033	0.7445	8	17
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	HLA-B40:21	AQTISGPTV	0.4572	0.8375	8	17
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	HLA-B39:02	AQTISGPTV	0.4119	0.9335	8	17
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	HLA-C17:01	QTISGPTVL	0.3992	0.9788	9	18
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	HLA-B07:13	TISGPTVLL	0.3095	0.8043	10	19
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	HLA-B40:21	QTISGPTVL	0.1097	0.8961	9	18
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	HLA-B40:21	TISGPTVLL	0.0888	0.5301	10	19
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	HLA-B07:13	ISGPTVLLL	0.0665	0.8175	11	20
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	HLA-B15:27	AQTISGPTVL	0.9935	0.9181	8	18
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	HLA-B15:33	AQTISGPTVL	0.9935	0.8982	8	18
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	HLA-B15:125	AQTISGPTVL	0.9935	0.8982	8	18
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	HLA-B15:34	AQTISGPTVL	0.9935	0.8982	8	18
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	HLA-B15:54	AQTISGPTVL	0.9811	0.8685	8	18
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	HLA-A68:02	QTISGPTVLL	0.979	0.681	9	19
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	HLA-B15:53	AQTISGPTVL	0.977	0.8872	8	18
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	HLA-B15:73	AQTISGPTVL	0.9743	0.9701	8	18
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	HLA-B15:50	AQTISGPTVL	0.9715	0.9234	8	18
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	HLA-B15:30	AQTISGPTVL	0.9605	0.9421	8	18
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	HLA-A69:01	QTISGPTVLL	0.9416	0.6597	9	19
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	HLA-B39:02	AQTISGPTVL	0.8891	0.975	8	18
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	HLA-B40:12	AQTISGPTVL	0.8368	0.8109	8	18
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	HLA-B40:49	AQTISGPTVL	0.8112	0.8018	8	18
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	HLA-B40:21	AQTISGPTVL	0.7155	0.9128	8	18
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	HLA-C03:05	IAQTISGPTVL	0.9996	0.9438	7	18
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	HLA-C03:03	IAQTISGPTVL	0.9995	0.9899	7	18
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	HLA-C03:04	IAQTISGPTVL	0.9995	0.9899	7	18
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	HLA-C03:17	IAQTISGPTVL	0.9992	0.971	7	18
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	HLA-B15:73	AQTISGPTVLL	0.9971	0.9815	8	19
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	HLA-B15:30	AQTISGPTVLL	0.995	0.9682	8	19
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	HLA-B40:49	AQTISGPTVLL	0.9831	0.8731	8	19
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	HLA-B35:13	IAQTISGPTVL	0.9824	0.798	7	18
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	HLA-B40:21	AQTISGPTVLL	0.9778	0.9364	8	19
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	HLA-C03:06	IAQTISGPTVL	0.9654	0.9908	7	18
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	HLA-B40:12	AQTISGPTVLL	0.9537	0.8882	8	19
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	HLA-B48:05	AQTISGPTVLL	0.8046	0.5554	8	19

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Potential FusionNeoAntigen Information of SLC25A16-DRGX in HLA II

SLC25A16-DRGX_70248224_50574426.msa

Potential FusionNeoAntigen Information
* We used NetMHCIIpan v4.1 (%rank<0.5).

Fusion gene	Hchr	Hbp	Tgene	Tchr	Tbp	HLA II	FusionNeoAntigen peptide	Neoantigen start (at BP 13)	Neoantigen end (at BP 13)
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	DRB1-0906	CGGVAGAIAQTISGP	0	15
SLC25A16-DRGX	chr10	70248224	chr10	50574426	996	DRB1-0906	GGVAGAIAQTISGPT	1	16

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Fusion breakpoint peptide structures of SLC25A16-DRGX

3D structures of the fusion breakpoint peptide of 14AA sequence that have potential fusion neoantigens
* The minimum length of the amino acid sequence in RoseTTAFold is 14AA. Here, we predicted the 14AA fusion protein breakpoint sequence not the fusion neoantigen peptide, which is shorter than 14 AA.

File name	BPseq	Hgene	Tgene	Hchr	Hbp	Tchr	Tbp	AAlen
272	AIAQTISGPTVLLL	SLC25A16	DRGX	chr10	70248224	chr10	50574426	996

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Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D of SLC25A16-DRGX

Virtual screening between 25 HLAs (from PDB) and FusionNeoAntigens
* We used Glide to predict the interaction between HLAs and neoantigens.

HLA allele	PDB ID	File name	BPseq	Docking score	Glide score
HLA-B14:02	3BVN	272	AIAQTISGPTVLLL	-7.15543	-7.26883
HLA-B14:02	3BVN	272	AIAQTISGPTVLLL	-4.77435	-5.80965
HLA-B52:01	3W39	272	AIAQTISGPTVLLL	-6.80875	-6.92215
HLA-B52:01	3W39	272	AIAQTISGPTVLLL	-4.20386	-5.23916
HLA-A11:01	4UQ2	272	AIAQTISGPTVLLL	-7.5194	-8.5547
HLA-A11:01	4UQ2	272	AIAQTISGPTVLLL	-6.9601	-7.0735
HLA-A24:02	5HGA	272	AIAQTISGPTVLLL	-7.52403	-7.63743
HLA-A24:02	5HGA	272	AIAQTISGPTVLLL	-5.82433	-6.85963
HLA-B27:05	6PYJ	272	AIAQTISGPTVLLL	-3.28285	-4.31815
HLA-B44:05	3DX8	272	AIAQTISGPTVLLL	-5.91172	-6.94702
HLA-B44:05	3DX8	272	AIAQTISGPTVLLL	-4.24346	-4.35686

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Vaccine Design for the FusionNeoAntigens of SLC25A16-DRGX

mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-Is.

Fusion gene	Hchr	Hbp	Tchr	Tbp	Start in +/-13AA	End in +/-13AA	FusionNeoAntigen peptide sequence	FusionNeoAntigen RNA sequence
SLC25A16-DRGX	chr10	70248224	chr10	50574426	10	19	TISGPTVLL	GACAATATCGGGGCCCACTGTGCTCTT
SLC25A16-DRGX	chr10	70248224	chr10	50574426	11	19	ISGPTVLL	AATATCGGGGCCCACTGTGCTCTT
SLC25A16-DRGX	chr10	70248224	chr10	50574426	11	20	ISGPTVLLL	AATATCGGGGCCCACTGTGCTCTTGCT
SLC25A16-DRGX	chr10	70248224	chr10	50574426	12	20	SGPTVLLL	ATCGGGGCCCACTGTGCTCTTGCT
SLC25A16-DRGX	chr10	70248224	chr10	50574426	7	18	IAQTISGPTVL	AATAGCGCAGACAATATCGGGGCCCACTGTGCT
SLC25A16-DRGX	chr10	70248224	chr10	50574426	8	17	AQTISGPTV	AGCGCAGACAATATCGGGGCCCACTGT
SLC25A16-DRGX	chr10	70248224	chr10	50574426	8	18	AQTISGPTVL	AGCGCAGACAATATCGGGGCCCACTGTGCT
SLC25A16-DRGX	chr10	70248224	chr10	50574426	8	19	AQTISGPTVLL	AGCGCAGACAATATCGGGGCCCACTGTGCTCTT
SLC25A16-DRGX	chr10	70248224	chr10	50574426	9	18	QTISGPTVL	GCAGACAATATCGGGGCCCACTGTGCT
SLC25A16-DRGX	chr10	70248224	chr10	50574426	9	19	QTISGPTVLL	GCAGACAATATCGGGGCCCACTGTGCTCTT

mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-IIs.

Fusion gene	Hchr	Hbp	Tchr	Tbp	Start in +/-13AA	End in +/-13AA	FusionNeoAntigen peptide	FusionNEoAntigen RNA sequence
SLC25A16-DRGX	chr10	70248224	chr10	50574426	0	15	CGGVAGAIAQTISGP	TTGTGGTGGTGTTGCTGGAGCAATAGCGCAGACAATATCGGGGCC
SLC25A16-DRGX	chr10	70248224	chr10	50574426	1	16	GGVAGAIAQTISGPT	TGGTGGTGTTGCTGGAGCAATAGCGCAGACAATATCGGGGCCCAC

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Information of the samples that have these potential fusion neoantigens of SLC25A16-DRGX

These samples were reported as having these fusion breakpoints. For individual breakpoints, we checked the open reading frames considering multiple gene isoforms and chose the in-frame fusion genes only. Then, we made fusion protein sequences and predicted the fusion neoantigens. These fusion-positive samples may have these potential fusion neoantigens.

Cancer type	Fusion gene	Hchr	Hbp	Henst	Tchr	Tbp	Tenst	Sample
SKCM	SLC25A16-DRGX	chr10	70248224	ENST00000539557	chr10	50574426	ENST00000374139	TCGA-W3-AA1V-06B

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Potential target of CAR-T therapy development for SLC25A16-DRGX

Predicted 3D structure. We used RoseTTAFold.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, to provide the retention of the transmembrane domain, we only show the protein feature retention information of those transmembrane features

* Minus value of BPloci means that the break point is located before the CDS.

- In-frame and retained 'Transmembrane'.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

SLC25A16

chr10:70248224

chr10:50574426

ENST00000609923

134_154

257

333.0

Transmembrane

Helical%3B Name%3D3

Hgene

SLC25A16

chr10:70248224

chr10:50574426

ENST00000609923

191_211

257

333.0

Transmembrane

Helical%3B Name%3D4

Hgene

SLC25A16

chr10:70248224

chr10:50574426

ENST00000609923

37_57

257

333.0

Transmembrane

Helical%3B Name%3D1

Hgene

SLC25A16

chr10:70248224

chr10:50574426

ENST00000609923

88_108

257

333.0

Transmembrane

Helical%3B Name%3D2

Subcellular localization prediction of the transmembrane domain retained fusion proteins
* We used DeepLoc 1.0. The order of the X-axis of the barplot is as follows: Entry_ID, Localization, Type, Nucleus, Cytoplasm, Extracellular, Mitochondrion, Cell_membrane, Endoplasmic_reticulum, Plastid, Golgi.apparatus, Lysosome.Vacuole, Peroxisome. Y-axis is the output score of DeepLoc. Clicking the image will open a new tab with a large image.

Hgene

Hchr

Hbp

Henst

Tgene

Tchr

Tbp

Tenst

DeepLoc result

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Related Drugs to SLC25A16-DRGX

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to SLC25A16-DRGX

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source

	Fusion Gene and Fusion Protein Summary
	Fusion Amino Acid Sequences (multiple BPs and multiple gene isoforms)
	Fusion Protein Breakpoint Sequences - (for the Screening of the FusionNeoAntigens)
	Potential FusionNeoAntigens in HLA I - (netMHCpan v4.1 + deepHLApan v1.1)
	Potential FusionNeoAntigens in HLA II - (netMHCIIpan v4.1)
	Fusion Breakpoint 14 AA Peptide Structure - (RoseTTAFold)
	Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D - (Glide)
	Vaccine Design for the FusionNeoAntigens (RNA/protein sequences)
	Potential target of CAR-T therapy development
	Information on the samples that have these potential fusion neoantigens
	Fusion Protein Targeting Drugs - (Manual Curation)
	Fusion Protein Related diseases - (Manual Curation)