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Fusion Protein:SLC25A3-EZH2 |
Fusion Gene and Fusion Protein Summary |
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Fusion partner gene information | Fusion gene name: SLC25A3-EZH2 | FusionPDB ID: 82679 | FusionGDB2.0 ID: 82679 | Hgene | Tgene | Gene symbol | SLC25A3 | EZH2 | Gene ID | 5250 | 2146 |
Gene name | solute carrier family 25 member 3 | enhancer of zeste 2 polycomb repressive complex 2 subunit | |
Synonyms | OK/SW-cl.48|PHC|PTP | ENX-1|ENX1|EZH2b|KMT6|KMT6A|WVS|WVS2 | |
Cytomap | 12q23.1 | 7q36.1 | |
Type of gene | protein-coding | protein-coding | |
Description | phosphate carrier protein, mitochondrialphosphate transport proteinsolute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3 | histone-lysine N-methyltransferase EZH2enhancer of zeste homolog 2lysine N-methyltransferase 6 | |
Modification date | 20200313 | 20200329 | |
UniProtAcc | . | Q15910 Main function of 5'-partner protein: FUNCTION: Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Displays a preference for substrates with less methylation, loses activity when progressively more methyl groups are incorporated into H3K27, H3K27me0 > H3K27me1 > H3K27me2 (PubMed:22323599, PubMed:30923826). Compared to EZH1-containing complexes, it is more abundant in embryonic stem cells and plays a major role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1, CDKN2A and retinoic acid target genes. EZH2 can also methylate non-histone proteins such as the transcription factor GATA4 and the nuclear receptor RORA. Regulates the circadian clock via histone methylation at the promoter of the circadian genes. Essential for the CRY1/2-mediated repression of the transcriptional activation of PER1/2 by the CLOCK-ARNTL/BMAL1 heterodimer; involved in the di and trimethylation of 'Lys-27' of histone H3 on PER1/2 promoters which is necessary for the CRY1/2 proteins to inhibit transcription. {ECO:0000269|PubMed:14532106, ECO:0000269|PubMed:15225548, ECO:0000269|PubMed:15231737, ECO:0000269|PubMed:15385962, ECO:0000269|PubMed:16179254, ECO:0000269|PubMed:16357870, ECO:0000269|PubMed:16618801, ECO:0000269|PubMed:16717091, ECO:0000269|PubMed:16936726, ECO:0000269|PubMed:17210787, ECO:0000269|PubMed:17344414, ECO:0000269|PubMed:18285464, ECO:0000269|PubMed:19026781, ECO:0000269|PubMed:20935635, ECO:0000269|PubMed:22323599, ECO:0000269|PubMed:23063525, ECO:0000269|PubMed:24474760, ECO:0000269|PubMed:30923826}. | |
Ensembl transtripts involved in fusion gene | ENST ids | ENST00000188376, ENST00000228318, ENST00000401722, ENST00000547534, ENST00000548847, ENST00000549338, ENST00000551265, ENST00000551917, ENST00000552981, | ENST00000536783, ENST00000320356, ENST00000350995, ENST00000460911, ENST00000476773, ENST00000478654, ENST00000483967, ENST00000541220, |
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0) | * DoF score | 13 X 12 X 4=624 | 10 X 7 X 5=350 |
# samples | 13 | 9 | |
** MAII score | log2(13/624*10)=-2.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(9/350*10)=-1.95935801550265 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Fusion gene context | PubMed: SLC25A3 [Title/Abstract] AND EZH2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Fusion neoantigen context | PubMed: SLC25A3 [Title/Abstract] AND EZH2 [Title/Abstract] AND neoantigen [Title/Abstract] | ||
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | SLC25A3(98987913)-EZH2(148511229), # samples:1 | ||
Anticipated loss of major functional domain due to fusion event. | SLC25A3-EZH2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. SLC25A3-EZH2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. SLC25A3-EZH2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. SLC25A3-EZH2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. SLC25A3-EZH2 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. SLC25A3-EZH2 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. SLC25A3-EZH2 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF. SLC25A3-EZH2 seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF. SLC25A3-EZH2 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. SLC25A3-EZH2 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | EZH2 | GO:0000122 | negative regulation of transcription by RNA polymerase II | 20154697 |
Tgene | EZH2 | GO:0010718 | positive regulation of epithelial to mesenchymal transition | 20154697 |
Tgene | EZH2 | GO:0043406 | positive regulation of MAP kinase activity | 20154697 |
Tgene | EZH2 | GO:0043547 | positive regulation of GTPase activity | 20154697 |
Tgene | EZH2 | GO:0045814 | negative regulation of gene expression, epigenetic | 20154697 |
Tgene | EZH2 | GO:0070734 | histone H3-K27 methylation | 24474760 |
Tgene | EZH2 | GO:0071902 | positive regulation of protein serine/threonine kinase activity | 20154697 |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:98987913/chr7:148511229) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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Fusion Amino Acid Sequences |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
ENST00000401722 | SLC25A3 | chr12 | 98987913 | + | ENST00000478654 | EZH2 | chr7 | 148511229 | - | 1153 | 307 | 150 | 890 | 246 |
ENST00000401722 | SLC25A3 | chr12 | 98987913 | + | ENST00000460911 | EZH2 | chr7 | 148511229 | - | 1152 | 307 | 150 | 890 | 246 |
ENST00000401722 | SLC25A3 | chr12 | 98987913 | + | ENST00000350995 | EZH2 | chr7 | 148511229 | - | 1152 | 307 | 150 | 890 | 246 |
ENST00000401722 | SLC25A3 | chr12 | 98987913 | + | ENST00000320356 | EZH2 | chr7 | 148511229 | - | 1152 | 307 | 150 | 890 | 246 |
ENST00000401722 | SLC25A3 | chr12 | 98987913 | + | ENST00000541220 | EZH2 | chr7 | 148511229 | - | 1152 | 307 | 150 | 890 | 246 |
ENST00000401722 | SLC25A3 | chr12 | 98987913 | + | ENST00000476773 | EZH2 | chr7 | 148511229 | - | 1055 | 307 | 150 | 890 | 246 |
ENST00000401722 | SLC25A3 | chr12 | 98987913 | + | ENST00000483967 | EZH2 | chr7 | 148511229 | - | 1012 | 307 | 150 | 890 | 246 |
ENST00000228318 | SLC25A3 | chr12 | 98987913 | + | ENST00000478654 | EZH2 | chr7 | 148511229 | - | 1123 | 277 | 93 | 860 | 255 |
ENST00000228318 | SLC25A3 | chr12 | 98987913 | + | ENST00000460911 | EZH2 | chr7 | 148511229 | - | 1122 | 277 | 93 | 860 | 255 |
ENST00000228318 | SLC25A3 | chr12 | 98987913 | + | ENST00000350995 | EZH2 | chr7 | 148511229 | - | 1122 | 277 | 93 | 860 | 255 |
ENST00000228318 | SLC25A3 | chr12 | 98987913 | + | ENST00000320356 | EZH2 | chr7 | 148511229 | - | 1122 | 277 | 93 | 860 | 255 |
ENST00000228318 | SLC25A3 | chr12 | 98987913 | + | ENST00000541220 | EZH2 | chr7 | 148511229 | - | 1122 | 277 | 93 | 860 | 255 |
ENST00000228318 | SLC25A3 | chr12 | 98987913 | + | ENST00000476773 | EZH2 | chr7 | 148511229 | - | 1025 | 277 | 93 | 860 | 255 |
ENST00000228318 | SLC25A3 | chr12 | 98987913 | + | ENST00000483967 | EZH2 | chr7 | 148511229 | - | 982 | 277 | 93 | 860 | 255 |
ENST00000188376 | SLC25A3 | chr12 | 98987913 | + | ENST00000478654 | EZH2 | chr7 | 148511229 | - | 1357 | 511 | 138 | 1094 | 318 |
ENST00000188376 | SLC25A3 | chr12 | 98987913 | + | ENST00000460911 | EZH2 | chr7 | 148511229 | - | 1356 | 511 | 138 | 1094 | 318 |
ENST00000188376 | SLC25A3 | chr12 | 98987913 | + | ENST00000350995 | EZH2 | chr7 | 148511229 | - | 1356 | 511 | 138 | 1094 | 318 |
ENST00000188376 | SLC25A3 | chr12 | 98987913 | + | ENST00000320356 | EZH2 | chr7 | 148511229 | - | 1356 | 511 | 138 | 1094 | 318 |
ENST00000188376 | SLC25A3 | chr12 | 98987913 | + | ENST00000541220 | EZH2 | chr7 | 148511229 | - | 1356 | 511 | 138 | 1094 | 318 |
ENST00000188376 | SLC25A3 | chr12 | 98987913 | + | ENST00000476773 | EZH2 | chr7 | 148511229 | - | 1259 | 511 | 138 | 1094 | 318 |
ENST00000188376 | SLC25A3 | chr12 | 98987913 | + | ENST00000483967 | EZH2 | chr7 | 148511229 | - | 1216 | 511 | 138 | 1094 | 318 |
ENST00000551917 | SLC25A3 | chr12 | 98987913 | + | ENST00000478654 | EZH2 | chr7 | 148511229 | - | 1094 | 248 | 91 | 831 | 246 |
ENST00000551917 | SLC25A3 | chr12 | 98987913 | + | ENST00000460911 | EZH2 | chr7 | 148511229 | - | 1093 | 248 | 91 | 831 | 246 |
ENST00000551917 | SLC25A3 | chr12 | 98987913 | + | ENST00000350995 | EZH2 | chr7 | 148511229 | - | 1093 | 248 | 91 | 831 | 246 |
ENST00000551917 | SLC25A3 | chr12 | 98987913 | + | ENST00000320356 | EZH2 | chr7 | 148511229 | - | 1093 | 248 | 91 | 831 | 246 |
ENST00000551917 | SLC25A3 | chr12 | 98987913 | + | ENST00000541220 | EZH2 | chr7 | 148511229 | - | 1093 | 248 | 91 | 831 | 246 |
ENST00000551917 | SLC25A3 | chr12 | 98987913 | + | ENST00000476773 | EZH2 | chr7 | 148511229 | - | 996 | 248 | 91 | 831 | 246 |
ENST00000551917 | SLC25A3 | chr12 | 98987913 | + | ENST00000483967 | EZH2 | chr7 | 148511229 | - | 953 | 248 | 91 | 831 | 246 |
ENST00000552981 | SLC25A3 | chr12 | 98987913 | + | ENST00000478654 | EZH2 | chr7 | 148511229 | - | 1088 | 242 | 58 | 825 | 255 |
ENST00000552981 | SLC25A3 | chr12 | 98987913 | + | ENST00000460911 | EZH2 | chr7 | 148511229 | - | 1087 | 242 | 58 | 825 | 255 |
ENST00000552981 | SLC25A3 | chr12 | 98987913 | + | ENST00000350995 | EZH2 | chr7 | 148511229 | - | 1087 | 242 | 58 | 825 | 255 |
ENST00000552981 | SLC25A3 | chr12 | 98987913 | + | ENST00000320356 | EZH2 | chr7 | 148511229 | - | 1087 | 242 | 58 | 825 | 255 |
ENST00000552981 | SLC25A3 | chr12 | 98987913 | + | ENST00000541220 | EZH2 | chr7 | 148511229 | - | 1087 | 242 | 58 | 825 | 255 |
ENST00000552981 | SLC25A3 | chr12 | 98987913 | + | ENST00000476773 | EZH2 | chr7 | 148511229 | - | 990 | 242 | 58 | 825 | 255 |
ENST00000552981 | SLC25A3 | chr12 | 98987913 | + | ENST00000483967 | EZH2 | chr7 | 148511229 | - | 947 | 242 | 58 | 825 | 255 |
ENST00000547534 | SLC25A3 | chr12 | 98987913 | + | ENST00000478654 | EZH2 | chr7 | 148511229 | - | 1062 | 216 | 32 | 799 | 255 |
ENST00000547534 | SLC25A3 | chr12 | 98987913 | + | ENST00000460911 | EZH2 | chr7 | 148511229 | - | 1061 | 216 | 32 | 799 | 255 |
ENST00000547534 | SLC25A3 | chr12 | 98987913 | + | ENST00000350995 | EZH2 | chr7 | 148511229 | - | 1061 | 216 | 32 | 799 | 255 |
ENST00000547534 | SLC25A3 | chr12 | 98987913 | + | ENST00000320356 | EZH2 | chr7 | 148511229 | - | 1061 | 216 | 32 | 799 | 255 |
ENST00000547534 | SLC25A3 | chr12 | 98987913 | + | ENST00000541220 | EZH2 | chr7 | 148511229 | - | 1061 | 216 | 32 | 799 | 255 |
ENST00000547534 | SLC25A3 | chr12 | 98987913 | + | ENST00000476773 | EZH2 | chr7 | 148511229 | - | 964 | 216 | 32 | 799 | 255 |
ENST00000547534 | SLC25A3 | chr12 | 98987913 | + | ENST00000483967 | EZH2 | chr7 | 148511229 | - | 921 | 216 | 32 | 799 | 255 |
ENST00000549338 | SLC25A3 | chr12 | 98987913 | + | ENST00000478654 | EZH2 | chr7 | 148511229 | - | 1056 | 210 | 53 | 793 | 246 |
ENST00000549338 | SLC25A3 | chr12 | 98987913 | + | ENST00000460911 | EZH2 | chr7 | 148511229 | - | 1055 | 210 | 53 | 793 | 246 |
ENST00000549338 | SLC25A3 | chr12 | 98987913 | + | ENST00000350995 | EZH2 | chr7 | 148511229 | - | 1055 | 210 | 53 | 793 | 246 |
ENST00000549338 | SLC25A3 | chr12 | 98987913 | + | ENST00000320356 | EZH2 | chr7 | 148511229 | - | 1055 | 210 | 53 | 793 | 246 |
ENST00000549338 | SLC25A3 | chr12 | 98987913 | + | ENST00000541220 | EZH2 | chr7 | 148511229 | - | 1055 | 210 | 53 | 793 | 246 |
ENST00000549338 | SLC25A3 | chr12 | 98987913 | + | ENST00000476773 | EZH2 | chr7 | 148511229 | - | 958 | 210 | 53 | 793 | 246 |
ENST00000549338 | SLC25A3 | chr12 | 98987913 | + | ENST00000483967 | EZH2 | chr7 | 148511229 | - | 915 | 210 | 53 | 793 | 246 |
ENST00000548847 | SLC25A3 | chr12 | 98987913 | + | ENST00000478654 | EZH2 | chr7 | 148511229 | - | 1257 | 411 | 38 | 994 | 318 |
ENST00000548847 | SLC25A3 | chr12 | 98987913 | + | ENST00000460911 | EZH2 | chr7 | 148511229 | - | 1256 | 411 | 38 | 994 | 318 |
ENST00000548847 | SLC25A3 | chr12 | 98987913 | + | ENST00000350995 | EZH2 | chr7 | 148511229 | - | 1256 | 411 | 38 | 994 | 318 |
ENST00000548847 | SLC25A3 | chr12 | 98987913 | + | ENST00000320356 | EZH2 | chr7 | 148511229 | - | 1256 | 411 | 38 | 994 | 318 |
ENST00000548847 | SLC25A3 | chr12 | 98987913 | + | ENST00000541220 | EZH2 | chr7 | 148511229 | - | 1256 | 411 | 38 | 994 | 318 |
ENST00000548847 | SLC25A3 | chr12 | 98987913 | + | ENST00000476773 | EZH2 | chr7 | 148511229 | - | 1159 | 411 | 38 | 994 | 318 |
ENST00000548847 | SLC25A3 | chr12 | 98987913 | + | ENST00000483967 | EZH2 | chr7 | 148511229 | - | 1116 | 411 | 38 | 994 | 318 |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
ENST00000401722 | ENST00000478654 | SLC25A3 | chr12 | 98987913 | + | EZH2 | chr7 | 148511229 | - | 0.00245531 | 0.9975447 |
ENST00000401722 | ENST00000460911 | SLC25A3 | chr12 | 98987913 | + | EZH2 | chr7 | 148511229 | - | 0.002475926 | 0.9975241 |
ENST00000401722 | ENST00000350995 | SLC25A3 | chr12 | 98987913 | + | EZH2 | chr7 | 148511229 | - | 0.002475926 | 0.9975241 |
ENST00000401722 | ENST00000320356 | SLC25A3 | chr12 | 98987913 | + | EZH2 | chr7 | 148511229 | - | 0.002475926 | 0.9975241 |
ENST00000401722 | ENST00000541220 | SLC25A3 | chr12 | 98987913 | + | EZH2 | chr7 | 148511229 | - | 0.002475926 | 0.9975241 |
ENST00000401722 | ENST00000476773 | SLC25A3 | chr12 | 98987913 | + | EZH2 | chr7 | 148511229 | - | 0.002904699 | 0.99709535 |
ENST00000401722 | ENST00000483967 | SLC25A3 | chr12 | 98987913 | + | EZH2 | chr7 | 148511229 | - | 0.003256522 | 0.9967435 |
ENST00000228318 | ENST00000478654 | SLC25A3 | chr12 | 98987913 | + | EZH2 | chr7 | 148511229 | - | 0.002511707 | 0.99748826 |
ENST00000228318 | ENST00000460911 | SLC25A3 | chr12 | 98987913 | + | EZH2 | chr7 | 148511229 | - | 0.00253019 | 0.9974698 |
ENST00000228318 | ENST00000350995 | SLC25A3 | chr12 | 98987913 | + | EZH2 | chr7 | 148511229 | - | 0.00253019 | 0.9974698 |
ENST00000228318 | ENST00000320356 | SLC25A3 | chr12 | 98987913 | + | EZH2 | chr7 | 148511229 | - | 0.00253019 | 0.9974698 |
ENST00000228318 | ENST00000541220 | SLC25A3 | chr12 | 98987913 | + | EZH2 | chr7 | 148511229 | - | 0.00253019 | 0.9974698 |
ENST00000228318 | ENST00000476773 | SLC25A3 | chr12 | 98987913 | + | EZH2 | chr7 | 148511229 | - | 0.002950849 | 0.99704915 |
ENST00000228318 | ENST00000483967 | SLC25A3 | chr12 | 98987913 | + | EZH2 | chr7 | 148511229 | - | 0.00334346 | 0.99665654 |
ENST00000188376 | ENST00000478654 | SLC25A3 | chr12 | 98987913 | + | EZH2 | chr7 | 148511229 | - | 0.002951828 | 0.9970482 |
ENST00000188376 | ENST00000460911 | SLC25A3 | chr12 | 98987913 | + | EZH2 | chr7 | 148511229 | - | 0.002983779 | 0.9970162 |
ENST00000188376 | ENST00000350995 | SLC25A3 | chr12 | 98987913 | + | EZH2 | chr7 | 148511229 | - | 0.002983779 | 0.9970162 |
ENST00000188376 | ENST00000320356 | SLC25A3 | chr12 | 98987913 | + | EZH2 | chr7 | 148511229 | - | 0.002983779 | 0.9970162 |
ENST00000188376 | ENST00000541220 | SLC25A3 | chr12 | 98987913 | + | EZH2 | chr7 | 148511229 | - | 0.002983779 | 0.9970162 |
ENST00000188376 | ENST00000476773 | SLC25A3 | chr12 | 98987913 | + | EZH2 | chr7 | 148511229 | - | 0.003329421 | 0.99667054 |
ENST00000188376 | ENST00000483967 | SLC25A3 | chr12 | 98987913 | + | EZH2 | chr7 | 148511229 | - | 0.003788359 | 0.99621165 |
ENST00000551917 | ENST00000478654 | SLC25A3 | chr12 | 98987913 | + | EZH2 | chr7 | 148511229 | - | 0.00248143 | 0.99751854 |
ENST00000551917 | ENST00000460911 | SLC25A3 | chr12 | 98987913 | + | EZH2 | chr7 | 148511229 | - | 0.002488994 | 0.997511 |
ENST00000551917 | ENST00000350995 | SLC25A3 | chr12 | 98987913 | + | EZH2 | chr7 | 148511229 | - | 0.002488994 | 0.997511 |
ENST00000551917 | ENST00000320356 | SLC25A3 | chr12 | 98987913 | + | EZH2 | chr7 | 148511229 | - | 0.002488994 | 0.997511 |
ENST00000551917 | ENST00000541220 | SLC25A3 | chr12 | 98987913 | + | EZH2 | chr7 | 148511229 | - | 0.002488994 | 0.997511 |
ENST00000551917 | ENST00000476773 | SLC25A3 | chr12 | 98987913 | + | EZH2 | chr7 | 148511229 | - | 0.00291309 | 0.99708694 |
ENST00000551917 | ENST00000483967 | SLC25A3 | chr12 | 98987913 | + | EZH2 | chr7 | 148511229 | - | 0.003133132 | 0.9968669 |
ENST00000552981 | ENST00000478654 | SLC25A3 | chr12 | 98987913 | + | EZH2 | chr7 | 148511229 | - | 0.002540041 | 0.99745995 |
ENST00000552981 | ENST00000460911 | SLC25A3 | chr12 | 98987913 | + | EZH2 | chr7 | 148511229 | - | 0.002543438 | 0.9974566 |
ENST00000552981 | ENST00000350995 | SLC25A3 | chr12 | 98987913 | + | EZH2 | chr7 | 148511229 | - | 0.002543438 | 0.9974566 |
ENST00000552981 | ENST00000320356 | SLC25A3 | chr12 | 98987913 | + | EZH2 | chr7 | 148511229 | - | 0.002543438 | 0.9974566 |
ENST00000552981 | ENST00000541220 | SLC25A3 | chr12 | 98987913 | + | EZH2 | chr7 | 148511229 | - | 0.002543438 | 0.9974566 |
ENST00000552981 | ENST00000476773 | SLC25A3 | chr12 | 98987913 | + | EZH2 | chr7 | 148511229 | - | 0.00298175 | 0.9970182 |
ENST00000552981 | ENST00000483967 | SLC25A3 | chr12 | 98987913 | + | EZH2 | chr7 | 148511229 | - | 0.003175916 | 0.99682415 |
ENST00000547534 | ENST00000478654 | SLC25A3 | chr12 | 98987913 | + | EZH2 | chr7 | 148511229 | - | 0.002710754 | 0.9972893 |
ENST00000547534 | ENST00000460911 | SLC25A3 | chr12 | 98987913 | + | EZH2 | chr7 | 148511229 | - | 0.002718608 | 0.9972813 |
ENST00000547534 | ENST00000350995 | SLC25A3 | chr12 | 98987913 | + | EZH2 | chr7 | 148511229 | - | 0.002718608 | 0.9972813 |
ENST00000547534 | ENST00000320356 | SLC25A3 | chr12 | 98987913 | + | EZH2 | chr7 | 148511229 | - | 0.002718608 | 0.9972813 |
ENST00000547534 | ENST00000541220 | SLC25A3 | chr12 | 98987913 | + | EZH2 | chr7 | 148511229 | - | 0.002718608 | 0.9972813 |
ENST00000547534 | ENST00000476773 | SLC25A3 | chr12 | 98987913 | + | EZH2 | chr7 | 148511229 | - | 0.003210106 | 0.9967899 |
ENST00000547534 | ENST00000483967 | SLC25A3 | chr12 | 98987913 | + | EZH2 | chr7 | 148511229 | - | 0.003487802 | 0.99651223 |
ENST00000549338 | ENST00000478654 | SLC25A3 | chr12 | 98987913 | + | EZH2 | chr7 | 148511229 | - | 0.002809442 | 0.99719054 |
ENST00000549338 | ENST00000460911 | SLC25A3 | chr12 | 98987913 | + | EZH2 | chr7 | 148511229 | - | 0.002815782 | 0.9971842 |
ENST00000549338 | ENST00000350995 | SLC25A3 | chr12 | 98987913 | + | EZH2 | chr7 | 148511229 | - | 0.002815782 | 0.9971842 |
ENST00000549338 | ENST00000320356 | SLC25A3 | chr12 | 98987913 | + | EZH2 | chr7 | 148511229 | - | 0.002815782 | 0.9971842 |
ENST00000549338 | ENST00000541220 | SLC25A3 | chr12 | 98987913 | + | EZH2 | chr7 | 148511229 | - | 0.002815782 | 0.9971842 |
ENST00000549338 | ENST00000476773 | SLC25A3 | chr12 | 98987913 | + | EZH2 | chr7 | 148511229 | - | 0.003357133 | 0.9966428 |
ENST00000549338 | ENST00000483967 | SLC25A3 | chr12 | 98987913 | + | EZH2 | chr7 | 148511229 | - | 0.003701664 | 0.9962984 |
ENST00000548847 | ENST00000478654 | SLC25A3 | chr12 | 98987913 | + | EZH2 | chr7 | 148511229 | - | 0.002866169 | 0.99713385 |
ENST00000548847 | ENST00000460911 | SLC25A3 | chr12 | 98987913 | + | EZH2 | chr7 | 148511229 | - | 0.002902919 | 0.99709713 |
ENST00000548847 | ENST00000350995 | SLC25A3 | chr12 | 98987913 | + | EZH2 | chr7 | 148511229 | - | 0.002902919 | 0.99709713 |
ENST00000548847 | ENST00000320356 | SLC25A3 | chr12 | 98987913 | + | EZH2 | chr7 | 148511229 | - | 0.002902919 | 0.99709713 |
ENST00000548847 | ENST00000541220 | SLC25A3 | chr12 | 98987913 | + | EZH2 | chr7 | 148511229 | - | 0.002902919 | 0.99709713 |
ENST00000548847 | ENST00000476773 | SLC25A3 | chr12 | 98987913 | + | EZH2 | chr7 | 148511229 | - | 0.003379473 | 0.99662054 |
ENST00000548847 | ENST00000483967 | SLC25A3 | chr12 | 98987913 | + | EZH2 | chr7 | 148511229 | - | 0.003951004 | 0.996049 |
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Get the fusion protein sequences from here. |
Fusion protein sequence information is available in the fasta format. >FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP |
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Fusion Protein Breakpoint Sequences for SLC25A3-EZH2 |
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Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | Length(fusion protein) | BP in fusion protein | Peptide |
SLC25A3 | chr12 | 98987913 | EZH2 | chr7 | 148511229 | 210 | 51 | QPRRPRNLAAAAVEGQNRFPGCRCKA |
SLC25A3 | chr12 | 98987913 | EZH2 | chr7 | 148511229 | 216 | 60 | QPRRPRNLAAAAVEGQNRFPGCRCKA |
SLC25A3 | chr12 | 98987913 | EZH2 | chr7 | 148511229 | 242 | 60 | QPRRPRNLAAAAVEGQNRFPGCRCKA |
SLC25A3 | chr12 | 98987913 | EZH2 | chr7 | 148511229 | 248 | 51 | QPRRPRNLAAAAVEGQNRFPGCRCKA |
SLC25A3 | chr12 | 98987913 | EZH2 | chr7 | 148511229 | 277 | 60 | QPRRPRNLAAAAVEGQNRFPGCRCKA |
SLC25A3 | chr12 | 98987913 | EZH2 | chr7 | 148511229 | 307 | 51 | QPRRPRNLAAAAVEGQNRFPGCRCKA |
SLC25A3 | chr12 | 98987913 | EZH2 | chr7 | 148511229 | 411 | 123 | QPRRPRNLAAAAVEGQNRFPGCRCKA |
SLC25A3 | chr12 | 98987913 | EZH2 | chr7 | 148511229 | 511 | 123 | QPRRPRNLAAAAVEGQNRFPGCRCKA |
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Potential FusionNeoAntigen Information of SLC25A3-EZH2 in HLA I |
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SLC25A3-EZH2_98987913_148511229.msa |
![]() * We used NetMHCpan v4.1 (%rank<0.5) and deepHLApan v1.1 (immunogenic score>0.5) |
Fusion gene | Hchr | Hbp | Tgene | Tchr | Tbp | HLA I | FusionNeoAntigen peptide | Binding score | Immunogenic score | Neoantigen start (at BP 13) | Neoantigen end (at BP 13) |
SLC25A3-EZH2 | chr12 | 98987913 | chr7 | 148511229 | 511 | HLA-B15:17 | AAVEGQNRF | 0.9886 | 0.9656 | 10 | 19 |
SLC25A3-EZH2 | chr12 | 98987913 | chr7 | 148511229 | 511 | HLA-B15:16 | AAVEGQNRF | 0.9867 | 0.903 | 10 | 19 |
SLC25A3-EZH2 | chr12 | 98987913 | chr7 | 148511229 | 511 | HLA-B46:01 | AAVEGQNRF | 0.9615 | 0.6572 | 10 | 19 |
SLC25A3-EZH2 | chr12 | 98987913 | chr7 | 148511229 | 511 | HLA-B13:01 | AAVEGQNRF | 0.1291 | 0.9869 | 10 | 19 |
SLC25A3-EZH2 | chr12 | 98987913 | chr7 | 148511229 | 511 | HLA-C03:08 | AAVEGQNRF | 0.9966 | 0.939 | 10 | 19 |
SLC25A3-EZH2 | chr12 | 98987913 | chr7 | 148511229 | 511 | HLA-C03:19 | AAVEGQNRF | 0.9947 | 0.991 | 10 | 19 |
SLC25A3-EZH2 | chr12 | 98987913 | chr7 | 148511229 | 511 | HLA-B15:05 | AAVEGQNRF | 0.9906 | 0.966 | 10 | 19 |
SLC25A3-EZH2 | chr12 | 98987913 | chr7 | 148511229 | 511 | HLA-C15:04 | AAVEGQNRF | 0.985 | 0.9656 | 10 | 19 |
SLC25A3-EZH2 | chr12 | 98987913 | chr7 | 148511229 | 511 | HLA-C03:07 | AAVEGQNRF | 0.9597 | 0.9919 | 10 | 19 |
SLC25A3-EZH2 | chr12 | 98987913 | chr7 | 148511229 | 511 | HLA-C08:13 | AAVEGQNRF | 0.7768 | 0.9885 | 10 | 19 |
SLC25A3-EZH2 | chr12 | 98987913 | chr7 | 148511229 | 511 | HLA-C08:04 | AAVEGQNRF | 0.7768 | 0.9885 | 10 | 19 |
SLC25A3-EZH2 | chr12 | 98987913 | chr7 | 148511229 | 511 | HLA-C03:14 | AAVEGQNRF | 0.7259 | 0.9822 | 10 | 19 |
SLC25A3-EZH2 | chr12 | 98987913 | chr7 | 148511229 | 511 | HLA-C12:04 | AAVEGQNRF | 0.7071 | 0.9954 | 10 | 19 |
SLC25A3-EZH2 | chr12 | 98987913 | chr7 | 148511229 | 511 | HLA-C12:12 | AAVEGQNRF | 0.7005 | 0.9454 | 10 | 19 |
SLC25A3-EZH2 | chr12 | 98987913 | chr7 | 148511229 | 511 | HLA-C06:03 | AAVEGQNRF | 0.6978 | 0.995 | 10 | 19 |
SLC25A3-EZH2 | chr12 | 98987913 | chr7 | 148511229 | 511 | HLA-C02:06 | AAVEGQNRF | 0.5335 | 0.9757 | 10 | 19 |
SLC25A3-EZH2 | chr12 | 98987913 | chr7 | 148511229 | 511 | HLA-C08:03 | AAVEGQNRF | 0.4367 | 0.9946 | 10 | 19 |
SLC25A3-EZH2 | chr12 | 98987913 | chr7 | 148511229 | 511 | HLA-C03:02 | AAVEGQNRF | 0.9971 | 0.9799 | 10 | 19 |
SLC25A3-EZH2 | chr12 | 98987913 | chr7 | 148511229 | 511 | HLA-C03:03 | AAVEGQNRF | 0.9965 | 0.9906 | 10 | 19 |
SLC25A3-EZH2 | chr12 | 98987913 | chr7 | 148511229 | 511 | HLA-C03:04 | AAVEGQNRF | 0.9965 | 0.9906 | 10 | 19 |
SLC25A3-EZH2 | chr12 | 98987913 | chr7 | 148511229 | 511 | HLA-B35:11 | AAVEGQNRF | 0.9914 | 0.9659 | 10 | 19 |
SLC25A3-EZH2 | chr12 | 98987913 | chr7 | 148511229 | 511 | HLA-B15:20 | AAVEGQNRF | 0.9909 | 0.9784 | 10 | 19 |
SLC25A3-EZH2 | chr12 | 98987913 | chr7 | 148511229 | 511 | HLA-B35:28 | AAVEGQNRF | 0.9895 | 0.9804 | 10 | 19 |
SLC25A3-EZH2 | chr12 | 98987913 | chr7 | 148511229 | 511 | HLA-B58:06 | AAVEGQNRF | 0.9877 | 0.9756 | 10 | 19 |
SLC25A3-EZH2 | chr12 | 98987913 | chr7 | 148511229 | 511 | HLA-B57:02 | AAVEGQNRF | 0.9866 | 0.9817 | 10 | 19 |
SLC25A3-EZH2 | chr12 | 98987913 | chr7 | 148511229 | 511 | HLA-C15:09 | AAVEGQNRF | 0.985 | 0.9656 | 10 | 19 |
SLC25A3-EZH2 | chr12 | 98987913 | chr7 | 148511229 | 511 | HLA-C03:05 | AAVEGQNRF | 0.9709 | 0.9263 | 10 | 19 |
SLC25A3-EZH2 | chr12 | 98987913 | chr7 | 148511229 | 511 | HLA-C03:17 | AAVEGQNRF | 0.9705 | 0.9726 | 10 | 19 |
SLC25A3-EZH2 | chr12 | 98987913 | chr7 | 148511229 | 511 | HLA-C16:04 | AAVEGQNRF | 0.9326 | 0.9866 | 10 | 19 |
SLC25A3-EZH2 | chr12 | 98987913 | chr7 | 148511229 | 511 | HLA-B15:08 | AAVEGQNRF | 0.9263 | 0.9499 | 10 | 19 |
SLC25A3-EZH2 | chr12 | 98987913 | chr7 | 148511229 | 511 | HLA-B15:24 | AAVEGQNRF | 0.9242 | 0.9635 | 10 | 19 |
SLC25A3-EZH2 | chr12 | 98987913 | chr7 | 148511229 | 511 | HLA-B35:13 | AAVEGQNRF | 0.9116 | 0.9721 | 10 | 19 |
SLC25A3-EZH2 | chr12 | 98987913 | chr7 | 148511229 | 511 | HLA-B35:43 | AAVEGQNRF | 0.908 | 0.9514 | 10 | 19 |
SLC25A3-EZH2 | chr12 | 98987913 | chr7 | 148511229 | 511 | HLA-C03:06 | AAVEGQNRF | 0.8224 | 0.9915 | 10 | 19 |
SLC25A3-EZH2 | chr12 | 98987913 | chr7 | 148511229 | 511 | HLA-C12:02 | AAVEGQNRF | 0.8009 | 0.9786 | 10 | 19 |
SLC25A3-EZH2 | chr12 | 98987913 | chr7 | 148511229 | 511 | HLA-C12:03 | AAVEGQNRF | 0.7515 | 0.9868 | 10 | 19 |
SLC25A3-EZH2 | chr12 | 98987913 | chr7 | 148511229 | 511 | HLA-C16:02 | AAVEGQNRF | 0.6465 | 0.9958 | 10 | 19 |
SLC25A3-EZH2 | chr12 | 98987913 | chr7 | 148511229 | 511 | HLA-C16:01 | AAVEGQNRF | 0.6424 | 0.9893 | 10 | 19 |
SLC25A3-EZH2 | chr12 | 98987913 | chr7 | 148511229 | 511 | HLA-C02:10 | AAVEGQNRF | 0.5798 | 0.9851 | 10 | 19 |
SLC25A3-EZH2 | chr12 | 98987913 | chr7 | 148511229 | 511 | HLA-C02:02 | AAVEGQNRF | 0.5798 | 0.9851 | 10 | 19 |
SLC25A3-EZH2 | chr12 | 98987913 | chr7 | 148511229 | 511 | HLA-C08:01 | AAVEGQNRF | 0.4367 | 0.9946 | 10 | 19 |
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Potential FusionNeoAntigen Information of SLC25A3-EZH2 in HLA II |
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SLC25A3-EZH2_98987913_148511229.msa |
![]() * We used NetMHCIIpan v4.1 (%rank<0.5). |
Fusion gene | Hchr | Hbp | Tgene | Tchr | Tbp | HLA II | FusionNeoAntigen peptide | Neoantigen start (at BP 13) | Neoantigen end (at BP 13) |
SLC25A3-EZH2 | chr12 | 98987913 | chr7 | 148511229 | 511 | DRB1-0451 | RPRNLAAAAVEGQNR | 3 | 18 |
SLC25A3-EZH2 | chr12 | 98987913 | chr7 | 148511229 | 511 | DRB1-0451 | PRNLAAAAVEGQNRF | 4 | 19 |
SLC25A3-EZH2 | chr12 | 98987913 | chr7 | 148511229 | 511 | DRB1-0478 | RPRNLAAAAVEGQNR | 3 | 18 |
SLC25A3-EZH2 | chr12 | 98987913 | chr7 | 148511229 | 511 | DRB1-0478 | PRNLAAAAVEGQNRF | 4 | 19 |
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Fusion breakpoint peptide structures of SLC25A3-EZH2 |
![]() * The minimum length of the amino acid sequence in RoseTTAFold is 14AA. Here, we predicted the 14AA fusion protein breakpoint sequence not the fusion neoantigen peptide, which is shorter than 14 AA. |
File name | BPseq | Hgene | Tgene | Hchr | Hbp | Tchr | Tbp | AAlen |
6238 | NLAAAAVEGQNRFP | SLC25A3 | EZH2 | chr12 | 98987913 | chr7 | 148511229 | 511 |
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Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D of SLC25A3-EZH2 |
![]() * We used Glide to predict the interaction between HLAs and neoantigens. |
HLA allele | PDB ID | File name | BPseq | Docking score | Glide score |
HLA-B14:02 | 3BVN | 6238 | NLAAAAVEGQNRFP | -7.9962 | -8.1096 |
HLA-B14:02 | 3BVN | 6238 | NLAAAAVEGQNRFP | -5.70842 | -6.74372 |
HLA-B52:01 | 3W39 | 6238 | NLAAAAVEGQNRFP | -6.83737 | -6.95077 |
HLA-B52:01 | 3W39 | 6238 | NLAAAAVEGQNRFP | -4.4836 | -5.5189 |
HLA-A11:01 | 4UQ2 | 6238 | NLAAAAVEGQNRFP | -10.0067 | -10.1201 |
HLA-A11:01 | 4UQ2 | 6238 | NLAAAAVEGQNRFP | -9.03915 | -10.0745 |
HLA-A24:02 | 5HGA | 6238 | NLAAAAVEGQNRFP | -6.56204 | -6.67544 |
HLA-A24:02 | 5HGA | 6238 | NLAAAAVEGQNRFP | -5.42271 | -6.45801 |
HLA-B44:05 | 3DX8 | 6238 | NLAAAAVEGQNRFP | -7.85648 | -8.89178 |
HLA-B44:05 | 3DX8 | 6238 | NLAAAAVEGQNRFP | -5.3978 | -5.5112 |
HLA-A02:01 | 6TDR | 6238 | NLAAAAVEGQNRFP | -3.37154 | -4.40684 |
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Vaccine Design for the FusionNeoAntigens of SLC25A3-EZH2 |
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Fusion gene | Hchr | Hbp | Tchr | Tbp | Start in +/-13AA | End in +/-13AA | FusionNeoAntigen peptide sequence | FusionNeoAntigen RNA sequence |
SLC25A3-EZH2 | chr12 | 98987913 | chr7 | 148511229 | 10 | 19 | AAVEGQNRF | CCGTGGAAGGTCAAAACCGCTTTCCGG |
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Fusion gene | Hchr | Hbp | Tchr | Tbp | Start in +/-13AA | End in +/-13AA | FusionNeoAntigen peptide | FusionNEoAntigen RNA sequence |
SLC25A3-EZH2 | chr12 | 98987913 | chr7 | 148511229 | 3 | 18 | RPRNLAAAAVEGQNR | CTCGCAACCTGGCAGCCGCCGCCGTGGAAGGTCAAAACCGCTTTC |
SLC25A3-EZH2 | chr12 | 98987913 | chr7 | 148511229 | 4 | 19 | PRNLAAAAVEGQNRF | GCAACCTGGCAGCCGCCGCCGTGGAAGGTCAAAACCGCTTTCCGG |
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Information of the samples that have these potential fusion neoantigens of SLC25A3-EZH2 |
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Cancer type | Fusion gene | Hchr | Hbp | Henst | Tchr | Tbp | Tenst | Sample |
STAD | SLC25A3-EZH2 | chr12 | 98987913 | ENST00000188376 | chr7 | 148511229 | ENST00000320356 | TCGA-BR-8081 |
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Potential target of CAR-T therapy development for SLC25A3-EZH2 |
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![]() * Minus value of BPloci means that the break point is located before the CDS. |
- In-frame and retained 'Transmembrane'. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
![]() * We used DeepLoc 1.0. The order of the X-axis of the barplot is as follows: Entry_ID, Localization, Type, Nucleus, Cytoplasm, Extracellular, Mitochondrion, Cell_membrane, Endoplasmic_reticulum, Plastid, Golgi.apparatus, Lysosome.Vacuole, Peroxisome. Y-axis is the output score of DeepLoc. Clicking the image will open a new tab with a large image. |
Hgene | Hchr | Hbp | Henst | Tgene | Tchr | Tbp | Tenst | DeepLoc result |
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Related Drugs to SLC25A3-EZH2 |
![]() (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
Hgene | Tgene | Drug | Source | PMID |
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Related Diseases to SLC25A3-EZH2 |
![]() (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
Hgene | Tgene | Disease | Source | PMID |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |