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Fusion Protein:SLC37A1-MTA1

Fusion Gene and Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: SLC37A1-MTA1
	FusionPDB ID: 83051
	FusionGDB2.0 ID: 83051
		Hgene	Tgene
	Gene symbol	SLC37A1	MTA1
	Gene ID	54020	9112
	Gene name	solute carrier family 37 member 1	metastasis associated 1
	Synonyms	G3PP	-
	Cytomap	21q22.3	14q32.33
	Type of gene	protein-coding	protein-coding
	Description	glucose-6-phosphate exchanger SLC37A1G-3-P permeaseG-3-P transporterglycerol-3-phosphate permeaseglycerol-3-phosphate transportersolute carrier family 37 (glucose-6-phosphate transporter), member 1solute carrier family 37 (glycerol-3-phosphate trans	metastasis-associated protein MTA1metastasis associated gene 1 protein
	Modification date	20200313	20200313
	UniProtAcc	.	Q13330 Main function of 5'-partner protein: FUNCTION: Transcriptional coregulator which can act as both a transcriptional corepressor and coactivator. As a part of the histone-deacetylase multiprotein complex (NuRD), regulates transcription of its targets by modifying the acetylation status of the target chromatin and cofactor accessibility to the target DNA. In conjunction with other components of NuRD, acts as a transcriptional corepressor of BRCA1, ESR1, TFF1 and CDKN1A. Acts as a transcriptional coactivator of BCAS3, PAX5 and SUMO2, independent of the NuRD complex. Stimulates the expression of WNT1 by inhibiting the expression of its transcriptional corepressor SIX3. Regulates p53-dependent and -independent DNA repair processes following genotoxic stress. Regulates the stability and function of p53/TP53 by inhibiting its ubiquitination by COP1 and MDM2 thereby regulating the p53-dependent DNA repair. Plays an important role in tumorigenesis, tumor invasion, and metastasis. Involved in the epigenetic regulation of ESR1 expression in breast cancer in a TFAP2C, IFI16 and HDAC4/5/6-dependent manner. Plays a role in the regulation of the circadian clock and is essential for the generation and maintenance of circadian rhythms under constant light and for normal entrainment of behavior to light-dark (LD) cycles. Positively regulates the CLOCK-ARNTL/BMAL1 heterodimer mediated transcriptional activation of its own transcription and the transcription of CRY1. Regulates deacetylation of ARNTL/BMAL1 by regulating SIRT1 expression, resulting in derepressing CRY1-mediated transcription repression. Isoform Short binds to ESR1 and sequesters it in the cytoplasm and enhances its non-genomic responses. With TFCP2L1, promotes establishment and maintenance of pluripotency in embryonic stem cells (ESCs) and inhibits endoderm differentiation (By similarity). {ECO:0000250\|UniProtKB:Q8K4B0, ECO:0000269\|PubMed:16617102, ECO:0000269\|PubMed:17671180, ECO:0000269\|PubMed:17922032, ECO:0000269\|PubMed:19837670, ECO:0000269\|PubMed:21965678, ECO:0000269\|PubMed:24413532}.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000352133, ENST00000398341, ENST00000454800,	ENST00000331320, ENST00000405646, ENST00000406191, ENST00000435036,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	7 X 6 X 3=126	6 X 9 X 5=270
	# samples	8	10
	** MAII score	log2(8/126*10)=-0.655351828612554 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(10/270*10)=-1.43295940727611 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Fusion gene context	PubMed: SLC37A1 [Title/Abstract] AND MTA1 [Title/Abstract] AND fusion [Title/Abstract]
Fusion neoantigen context	PubMed: SLC37A1 [Title/Abstract] AND MTA1 [Title/Abstract] AND neoantigen [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	SLC37A1(43988548)-MTA1(105932763), # samples:1
Anticipated loss of major functional domain due to fusion event.	SLC37A1-MTA1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. SLC37A1-MTA1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. SLC37A1-MTA1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. SLC37A1-MTA1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	SLC37A1	GO:0015760	glucose-6-phosphate transport	21949678
Hgene	SLC37A1	GO:0035435	phosphate ion transmembrane transport	21949678
Tgene	MTA1	GO:0010212	response to ionizing radiation	19805145
Tgene	MTA1	GO:1902499	positive regulation of protein autoubiquitination	19805145

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr21:43988548/chr14:105932763)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Retention analysis results of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features, are available here.

Fusion gene breakpoints across SLC37A1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across MTA1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Amino Acid Sequences

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000398341	SLC37A1	chr21	43988548	-	ENST00000331320	MTA1	chr14	105932763	+	2873	1835	412	2358	648
ENST00000398341	SLC37A1	chr21	43988548	-	ENST00000406191	MTA1	chr14	105932763	+	2837	1835	412	2322	636
ENST00000398341	SLC37A1	chr21	43988548	-	ENST00000405646	MTA1	chr14	105932763	+	2873	1835	412	2358	648
ENST00000398341	SLC37A1	chr21	43988548	-	ENST00000435036	MTA1	chr14	105932763	+	2839	1835	412	2370	652
ENST00000352133	SLC37A1	chr21	43988548	-	ENST00000331320	MTA1	chr14	105932763	+	3443	2405	982	2928	648
ENST00000352133	SLC37A1	chr21	43988548	-	ENST00000406191	MTA1	chr14	105932763	+	3407	2405	982	2892	636
ENST00000352133	SLC37A1	chr21	43988548	-	ENST00000405646	MTA1	chr14	105932763	+	3443	2405	982	2928	648
ENST00000352133	SLC37A1	chr21	43988548	-	ENST00000435036	MTA1	chr14	105932763	+	3409	2405	982	2940	652

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000398341	ENST00000331320	SLC37A1	chr21	43988548	-	MTA1	chr14	105932763	+	0.007843455	0.9921565
ENST00000398341	ENST00000406191	SLC37A1	chr21	43988548	-	MTA1	chr14	105932763	+	0.006301333	0.9936986
ENST00000398341	ENST00000405646	SLC37A1	chr21	43988548	-	MTA1	chr14	105932763	+	0.007843455	0.9921565
ENST00000398341	ENST00000435036	SLC37A1	chr21	43988548	-	MTA1	chr14	105932763	+	0.008626649	0.99137336
ENST00000352133	ENST00000331320	SLC37A1	chr21	43988548	-	MTA1	chr14	105932763	+	0.007908795	0.9920912
ENST00000352133	ENST00000406191	SLC37A1	chr21	43988548	-	MTA1	chr14	105932763	+	0.006520932	0.993479
ENST00000352133	ENST00000405646	SLC37A1	chr21	43988548	-	MTA1	chr14	105932763	+	0.007908795	0.9920912
ENST00000352133	ENST00000435036	SLC37A1	chr21	43988548	-	MTA1	chr14	105932763	+	0.008717786	0.9912822

Predicted full-length fusion amino acid sequences. For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among all the predicted ones.

Get the fusion protein sequences from here.

Fusion protein sequence information is available in the fasta format.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

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Fusion Protein Breakpoint Sequences for SLC37A1-MTA1

+/-13 AA sequence from the breakpoints of the fusion protein sequences.

Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	Length(fusion protein)	BP in fusion protein	Peptide
SLC37A1	chr21	43988548	MTA1	chr14	105932763	1835	474	STVTAIIDGTGSVETHPRPPKPDPVK
SLC37A1	chr21	43988548	MTA1	chr14	105932763	2405	474	STVTAIIDGTGSVETHPRPPKPDPVK

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Potential FusionNeoAntigen Information of SLC37A1-MTA1 in HLA I

Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.

SLC37A1-MTA1_43988548_105932763.msa

Potential FusionNeoAntigen Information
* We used NetMHCpan v4.1 (%rank<0.5) and deepHLApan v1.1 (immunogenic score>0.5)

Fusion gene	Hchr	Hbp	Tgene	Tchr	Tbp	HLA I	FusionNeoAntigen peptide	Binding score	Immunogenic score	Neoantigen start (at BP 13)	Neoantigen end (at BP 13)
SLC37A1-MTA1	chr21	43988548	chr14	105932763	2405	HLA-A30:01	SVETHPRPPK	0.9503	0.7124	11	21

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Potential FusionNeoAntigen Information of SLC37A1-MTA1 in HLA II

SLC37A1-MTA1_43988548_105932763.msa

Potential FusionNeoAntigen Information
* We used NetMHCIIpan v4.1 (%rank<0.5).

Fusion gene	Hchr	Hbp	Tgene	Tchr	Tbp	HLA II	FusionNeoAntigen peptide	Neoantigen start (at BP 13)	Neoantigen end (at BP 13)
SLC37A1-MTA1	chr21	43988548	chr14	105932763	2405	DRB1-1102	TGSVETHPRPPKPDP	9	24
SLC37A1-MTA1	chr21	43988548	chr14	105932763	2405	DRB1-1102	GTGSVETHPRPPKPD	8	23
SLC37A1-MTA1	chr21	43988548	chr14	105932763	2405	DRB1-1116	TGSVETHPRPPKPDP	9	24
SLC37A1-MTA1	chr21	43988548	chr14	105932763	2405	DRB1-1116	GTGSVETHPRPPKPD	8	23
SLC37A1-MTA1	chr21	43988548	chr14	105932763	2405	DRB1-1121	TGSVETHPRPPKPDP	9	24
SLC37A1-MTA1	chr21	43988548	chr14	105932763	2405	DRB1-1121	GTGSVETHPRPPKPD	8	23
SLC37A1-MTA1	chr21	43988548	chr14	105932763	2405	DRB1-1136	TGSVETHPRPPKPDP	9	24
SLC37A1-MTA1	chr21	43988548	chr14	105932763	2405	DRB1-1136	GTGSVETHPRPPKPD	8	23
SLC37A1-MTA1	chr21	43988548	chr14	105932763	2405	DRB1-1148	TGSVETHPRPPKPDP	9	24
SLC37A1-MTA1	chr21	43988548	chr14	105932763	2405	DRB1-1148	GTGSVETHPRPPKPD	8	23
SLC37A1-MTA1	chr21	43988548	chr14	105932763	2405	DRB1-1159	TGSVETHPRPPKPDP	9	24
SLC37A1-MTA1	chr21	43988548	chr14	105932763	2405	DRB1-1165	TGSVETHPRPPKPDP	9	24
SLC37A1-MTA1	chr21	43988548	chr14	105932763	2405	DRB1-1165	GTGSVETHPRPPKPD	8	23
SLC37A1-MTA1	chr21	43988548	chr14	105932763	2405	DRB1-1168	TGSVETHPRPPKPDP	9	24
SLC37A1-MTA1	chr21	43988548	chr14	105932763	2405	DRB1-1170	TGSVETHPRPPKPDP	9	24
SLC37A1-MTA1	chr21	43988548	chr14	105932763	2405	DRB1-1186	TGSVETHPRPPKPDP	9	24
SLC37A1-MTA1	chr21	43988548	chr14	105932763	2405	DRB1-1186	GTGSVETHPRPPKPD	8	23
SLC37A1-MTA1	chr21	43988548	chr14	105932763	2405	DRB1-1301	TGSVETHPRPPKPDP	9	24
SLC37A1-MTA1	chr21	43988548	chr14	105932763	2405	DRB1-1301	GTGSVETHPRPPKPD	8	23
SLC37A1-MTA1	chr21	43988548	chr14	105932763	2405	DRB1-1308	TGSVETHPRPPKPDP	9	24
SLC37A1-MTA1	chr21	43988548	chr14	105932763	2405	DRB1-1308	GTGSVETHPRPPKPD	8	23
SLC37A1-MTA1	chr21	43988548	chr14	105932763	2405	DRB1-1316	TGSVETHPRPPKPDP	9	24
SLC37A1-MTA1	chr21	43988548	chr14	105932763	2405	DRB1-1316	GTGSVETHPRPPKPD	8	23
SLC37A1-MTA1	chr21	43988548	chr14	105932763	2405	DRB1-1317	TGSVETHPRPPKPDP	9	24
SLC37A1-MTA1	chr21	43988548	chr14	105932763	2405	DRB1-1319	TGSVETHPRPPKPDP	9	24
SLC37A1-MTA1	chr21	43988548	chr14	105932763	2405	DRB1-1320	TGSVETHPRPPKPDP	9	24
SLC37A1-MTA1	chr21	43988548	chr14	105932763	2405	DRB1-1320	GTGSVETHPRPPKPD	8	23
SLC37A1-MTA1	chr21	43988548	chr14	105932763	2405	DRB1-1322	TGSVETHPRPPKPDP	9	24
SLC37A1-MTA1	chr21	43988548	chr14	105932763	2405	DRB1-1322	GTGSVETHPRPPKPD	8	23
SLC37A1-MTA1	chr21	43988548	chr14	105932763	2405	DRB1-1327	TGSVETHPRPPKPDP	9	24
SLC37A1-MTA1	chr21	43988548	chr14	105932763	2405	DRB1-1327	GTGSVETHPRPPKPD	8	23
SLC37A1-MTA1	chr21	43988548	chr14	105932763	2405	DRB1-1329	TGSVETHPRPPKPDP	9	24
SLC37A1-MTA1	chr21	43988548	chr14	105932763	2405	DRB1-1335	TGSVETHPRPPKPDP	9	24
SLC37A1-MTA1	chr21	43988548	chr14	105932763	2405	DRB1-1335	GTGSVETHPRPPKPD	8	23
SLC37A1-MTA1	chr21	43988548	chr14	105932763	2405	DRB1-1343	TGSVETHPRPPKPDP	9	24
SLC37A1-MTA1	chr21	43988548	chr14	105932763	2405	DRB1-1351	TGSVETHPRPPKPDP	9	24
SLC37A1-MTA1	chr21	43988548	chr14	105932763	2405	DRB1-1351	GTGSVETHPRPPKPD	8	23
SLC37A1-MTA1	chr21	43988548	chr14	105932763	2405	DRB1-1352	TGSVETHPRPPKPDP	9	24
SLC37A1-MTA1	chr21	43988548	chr14	105932763	2405	DRB1-1352	GTGSVETHPRPPKPD	8	23
SLC37A1-MTA1	chr21	43988548	chr14	105932763	2405	DRB1-1353	TGSVETHPRPPKPDP	9	24
SLC37A1-MTA1	chr21	43988548	chr14	105932763	2405	DRB1-1359	TGSVETHPRPPKPDP	9	24
SLC37A1-MTA1	chr21	43988548	chr14	105932763	2405	DRB1-1359	GTGSVETHPRPPKPD	8	23
SLC37A1-MTA1	chr21	43988548	chr14	105932763	2405	DRB1-1361	TGSVETHPRPPKPDP	9	24
SLC37A1-MTA1	chr21	43988548	chr14	105932763	2405	DRB1-1361	GTGSVETHPRPPKPD	8	23
SLC37A1-MTA1	chr21	43988548	chr14	105932763	2405	DRB1-1364	TGSVETHPRPPKPDP	9	24
SLC37A1-MTA1	chr21	43988548	chr14	105932763	2405	DRB1-1364	GTGSVETHPRPPKPD	8	23
SLC37A1-MTA1	chr21	43988548	chr14	105932763	2405	DRB1-1368	TGSVETHPRPPKPDP	9	24
SLC37A1-MTA1	chr21	43988548	chr14	105932763	2405	DRB1-1368	GTGSVETHPRPPKPD	8	23
SLC37A1-MTA1	chr21	43988548	chr14	105932763	2405	DRB1-1369	TGSVETHPRPPKPDP	9	24
SLC37A1-MTA1	chr21	43988548	chr14	105932763	2405	DRB1-1369	GTGSVETHPRPPKPD	8	23
SLC37A1-MTA1	chr21	43988548	chr14	105932763	2405	DRB1-1370	TGSVETHPRPPKPDP	9	24
SLC37A1-MTA1	chr21	43988548	chr14	105932763	2405	DRB1-1370	GTGSVETHPRPPKPD	8	23
SLC37A1-MTA1	chr21	43988548	chr14	105932763	2405	DRB1-1371	TGSVETHPRPPKPDP	9	24
SLC37A1-MTA1	chr21	43988548	chr14	105932763	2405	DRB1-1371	GTGSVETHPRPPKPD	8	23
SLC37A1-MTA1	chr21	43988548	chr14	105932763	2405	DRB1-1371	GSVETHPRPPKPDPV	10	25
SLC37A1-MTA1	chr21	43988548	chr14	105932763	2405	DRB1-1372	TGSVETHPRPPKPDP	9	24
SLC37A1-MTA1	chr21	43988548	chr14	105932763	2405	DRB1-1372	GTGSVETHPRPPKPD	8	23
SLC37A1-MTA1	chr21	43988548	chr14	105932763	2405	DRB1-1376	TGSVETHPRPPKPDP	9	24
SLC37A1-MTA1	chr21	43988548	chr14	105932763	2405	DRB1-1378	TGSVETHPRPPKPDP	9	24
SLC37A1-MTA1	chr21	43988548	chr14	105932763	2405	DRB1-1378	GTGSVETHPRPPKPD	8	23
SLC37A1-MTA1	chr21	43988548	chr14	105932763	2405	DRB1-1379	TGSVETHPRPPKPDP	9	24
SLC37A1-MTA1	chr21	43988548	chr14	105932763	2405	DRB1-1379	GTGSVETHPRPPKPD	8	23
SLC37A1-MTA1	chr21	43988548	chr14	105932763	2405	DRB1-1380	TGSVETHPRPPKPDP	9	24
SLC37A1-MTA1	chr21	43988548	chr14	105932763	2405	DRB1-1380	GTGSVETHPRPPKPD	8	23
SLC37A1-MTA1	chr21	43988548	chr14	105932763	2405	DRB1-1383	TGSVETHPRPPKPDP	9	24
SLC37A1-MTA1	chr21	43988548	chr14	105932763	2405	DRB1-1383	GTGSVETHPRPPKPD	8	23
SLC37A1-MTA1	chr21	43988548	chr14	105932763	2405	DRB1-1384	TGSVETHPRPPKPDP	9	24
SLC37A1-MTA1	chr21	43988548	chr14	105932763	2405	DRB1-1384	GTGSVETHPRPPKPD	8	23
SLC37A1-MTA1	chr21	43988548	chr14	105932763	2405	DRB1-1387	TGSVETHPRPPKPDP	9	24
SLC37A1-MTA1	chr21	43988548	chr14	105932763	2405	DRB1-1387	GTGSVETHPRPPKPD	8	23
SLC37A1-MTA1	chr21	43988548	chr14	105932763	2405	DRB1-1391	TGSVETHPRPPKPDP	9	24
SLC37A1-MTA1	chr21	43988548	chr14	105932763	2405	DRB1-1391	GTGSVETHPRPPKPD	8	23
SLC37A1-MTA1	chr21	43988548	chr14	105932763	2405	DRB1-1392	TGSVETHPRPPKPDP	9	24
SLC37A1-MTA1	chr21	43988548	chr14	105932763	2405	DRB1-1392	GTGSVETHPRPPKPD	8	23
SLC37A1-MTA1	chr21	43988548	chr14	105932763	2405	DRB1-1398	TGSVETHPRPPKPDP	9	24
SLC37A1-MTA1	chr21	43988548	chr14	105932763	2405	DRB1-1398	GTGSVETHPRPPKPD	8	23

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Fusion breakpoint peptide structures of SLC37A1-MTA1

3D structures of the fusion breakpoint peptide of 14AA sequence that have potential fusion neoantigens
* The minimum length of the amino acid sequence in RoseTTAFold is 14AA. Here, we predicted the 14AA fusion protein breakpoint sequence not the fusion neoantigen peptide, which is shorter than 14 AA.

File name	BPseq	Hgene	Tgene	Hchr	Hbp	Tchr	Tbp	AAlen
3625	IDGTGSVETHPRPP	SLC37A1	MTA1	chr21	43988548	chr14	105932763	2405

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Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D of SLC37A1-MTA1

Virtual screening between 25 HLAs (from PDB) and FusionNeoAntigens
* We used Glide to predict the interaction between HLAs and neoantigens.

HLA allele	PDB ID	File name	BPseq	Docking score	Glide score
HLA-B14:02	3BVN	3625	IDGTGSVETHPRPP	-7.9962	-8.1096
HLA-B14:02	3BVN	3625	IDGTGSVETHPRPP	-5.70842	-6.74372
HLA-B52:01	3W39	3625	IDGTGSVETHPRPP	-6.83737	-6.95077
HLA-B52:01	3W39	3625	IDGTGSVETHPRPP	-4.4836	-5.5189
HLA-A11:01	4UQ2	3625	IDGTGSVETHPRPP	-10.0067	-10.1201
HLA-A11:01	4UQ2	3625	IDGTGSVETHPRPP	-9.03915	-10.0745
HLA-A24:02	5HGA	3625	IDGTGSVETHPRPP	-6.56204	-6.67544
HLA-A24:02	5HGA	3625	IDGTGSVETHPRPP	-5.42271	-6.45801
HLA-B44:05	3DX8	3625	IDGTGSVETHPRPP	-7.85648	-8.89178
HLA-B44:05	3DX8	3625	IDGTGSVETHPRPP	-5.3978	-5.5112
HLA-A02:01	6TDR	3625	IDGTGSVETHPRPP	-3.37154	-4.40684

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Vaccine Design for the FusionNeoAntigens of SLC37A1-MTA1

mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-Is.

Fusion gene	Hchr	Hbp	Tchr	Tbp	Start in +/-13AA	End in +/-13AA	FusionNeoAntigen peptide sequence	FusionNeoAntigen RNA sequence
SLC37A1-MTA1	chr21	43988548	chr14	105932763	11	21	SVETHPRPPK	CTGTAGAGACCCACCCCCGCCCCCCCAAGC

mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-IIs.

Fusion gene	Hchr	Hbp	Tchr	Tbp	Start in +/-13AA	End in +/-13AA	FusionNeoAntigen peptide	FusionNEoAntigen RNA sequence
SLC37A1-MTA1	chr21	43988548	chr14	105932763	10	25	GSVETHPRPPKPDPV	GCTCTGTAGAGACCCACCCCCGCCCCCCCAAGCCTGACCCCGTGA
SLC37A1-MTA1	chr21	43988548	chr14	105932763	8	23	GTGSVETHPRPPKPD	GGACGGGCTCTGTAGAGACCCACCCCCGCCCCCCCAAGCCTGACC
SLC37A1-MTA1	chr21	43988548	chr14	105932763	9	24	TGSVETHPRPPKPDP	CGGGCTCTGTAGAGACCCACCCCCGCCCCCCCAAGCCTGACCCCG

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Information of the samples that have these potential fusion neoantigens of SLC37A1-MTA1

These samples were reported as having these fusion breakpoints. For individual breakpoints, we checked the open reading frames considering multiple gene isoforms and chose the in-frame fusion genes only. Then, we made fusion protein sequences and predicted the fusion neoantigens. These fusion-positive samples may have these potential fusion neoantigens.

Cancer type	Fusion gene	Hchr	Hbp	Henst	Tchr	Tbp	Tenst	Sample
PRAD	SLC37A1-MTA1	chr21	43988548	ENST00000352133	chr14	105932763	ENST00000331320	TCGA-EJ-5504-01A

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Potential target of CAR-T therapy development for SLC37A1-MTA1

Predicted 3D structure. We used RoseTTAFold.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, to provide the retention of the transmembrane domain, we only show the protein feature retention information of those transmembrane features

* Minus value of BPloci means that the break point is located before the CDS.

- In-frame and retained 'Transmembrane'.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

SLC37A1

chr21:43988548

chr14:105932763

ENST00000352133

100_120

474

534.0

Transmembrane

Helical

Hgene

SLC37A1

chr21:43988548

chr14:105932763

ENST00000352133

129_149

474

534.0

Transmembrane

Helical

Hgene

SLC37A1

chr21:43988548

chr14:105932763

ENST00000352133

157_177

474

534.0

Transmembrane

Helical

Hgene

SLC37A1

chr21:43988548

chr14:105932763

ENST00000352133

18_38

474

534.0

Transmembrane

Helical

Hgene

SLC37A1

chr21:43988548

chr14:105932763

ENST00000352133

222_242

474

534.0

Transmembrane

Helical

Hgene

SLC37A1

chr21:43988548

chr14:105932763

ENST00000352133

304_324

474

534.0

Transmembrane

Helical

Hgene

SLC37A1

chr21:43988548

chr14:105932763

ENST00000352133

334_354

474

534.0

Transmembrane

Helical

Hgene

SLC37A1

chr21:43988548

chr14:105932763

ENST00000352133

366_386

474

534.0

Transmembrane

Helical

Hgene

SLC37A1

chr21:43988548

chr14:105932763

ENST00000352133

394_414

474

534.0

Transmembrane

Helical

Hgene

SLC37A1

chr21:43988548

chr14:105932763

ENST00000352133

423_443

474

534.0

Transmembrane

Helical

Hgene

SLC37A1

chr21:43988548

chr14:105932763

ENST00000398341

100_120

474

534.0

Transmembrane

Helical

Hgene

SLC37A1

chr21:43988548

chr14:105932763

ENST00000398341

129_149

474

534.0

Transmembrane

Helical

Hgene

SLC37A1

chr21:43988548

chr14:105932763

ENST00000398341

157_177

474

534.0

Transmembrane

Helical

Hgene

SLC37A1

chr21:43988548

chr14:105932763

ENST00000398341

18_38

474

534.0

Transmembrane

Helical

Hgene

SLC37A1

chr21:43988548

chr14:105932763

ENST00000398341

222_242

474

534.0

Transmembrane

Helical

Hgene

SLC37A1

chr21:43988548

chr14:105932763

ENST00000398341

304_324

474

534.0

Transmembrane

Helical

Hgene

SLC37A1

chr21:43988548

chr14:105932763

ENST00000398341

334_354

474

534.0

Transmembrane

Helical

Hgene

SLC37A1

chr21:43988548

chr14:105932763

ENST00000398341

366_386

474

534.0

Transmembrane

Helical

Hgene

SLC37A1

chr21:43988548

chr14:105932763

ENST00000398341

394_414

474

534.0

Transmembrane

Helical

Hgene

SLC37A1

chr21:43988548

chr14:105932763

ENST00000398341

423_443

474

534.0

Transmembrane

Helical

Subcellular localization prediction of the transmembrane domain retained fusion proteins
* We used DeepLoc 1.0. The order of the X-axis of the barplot is as follows: Entry_ID, Localization, Type, Nucleus, Cytoplasm, Extracellular, Mitochondrion, Cell_membrane, Endoplasmic_reticulum, Plastid, Golgi.apparatus, Lysosome.Vacuole, Peroxisome. Y-axis is the output score of DeepLoc. Clicking the image will open a new tab with a large image.

Hgene

Hchr

Hbp

Henst

Tgene

Tchr

Tbp

Tenst

DeepLoc result

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Related Drugs to SLC37A1-MTA1

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to SLC37A1-MTA1

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source

	Fusion Gene and Fusion Protein Summary
	Fusion Amino Acid Sequences (multiple BPs and multiple gene isoforms)
	Fusion Protein Breakpoint Sequences - (for the Screening of the FusionNeoAntigens)
	Potential FusionNeoAntigens in HLA I - (netMHCpan v4.1 + deepHLApan v1.1)
	Potential FusionNeoAntigens in HLA II - (netMHCIIpan v4.1)
	Fusion Breakpoint 14 AA Peptide Structure - (RoseTTAFold)
	Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D - (Glide)
	Vaccine Design for the FusionNeoAntigens (RNA/protein sequences)
	Potential target of CAR-T therapy development
	Information on the samples that have these potential fusion neoantigens
	Fusion Protein Targeting Drugs - (Manual Curation)
	Fusion Protein Related diseases - (Manual Curation)