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Fusion Protein:SMARCA4-KCNMA1 |
Fusion Gene and Fusion Protein Summary |
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Fusion partner gene information | Fusion gene name: SMARCA4-KCNMA1 | FusionPDB ID: 83893 | FusionGDB2.0 ID: 83893 | Hgene | Tgene | Gene symbol | SMARCA4 | KCNMA1 | Gene ID | 6597 | 3778 |
Gene name | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 | potassium calcium-activated channel subfamily M alpha 1 | |
Synonyms | BAF190|BAF190A|BRG1|CSS4|MRD16|RTPS2|SNF2|SNF2-beta|SNF2L4|SNF2LB|SWI2|hSNF2b | BKTM|CADEDS|IEG16|KCa1.1|LIWAS|MaxiK|PNKD3|SAKCA|SLO|SLO-ALPHA|SLO1|bA205K10.1|hSlo|mSLO1 | |
Cytomap | 19p13.2 | 10q22.3 | |
Type of gene | protein-coding | protein-coding | |
Description | transcription activator BRG1ATP-dependent helicase SMARCA4BRG1-associated factor 190ABRM/SWI2-related gene 1SNF2-like 4brahma protein-like 1global transcription activator homologous sequencehomeotic gene regulatormitotic growth and transcription a | calcium-activated potassium channel subunit alpha-1uncharacterized proteinBK channel alpha subunitBKCA alpha subunitbig potassium channel alpha subunitcalcium-activated potassium channel, subfamily M subunit alpha-1k(VCA)alphamaxi-K channel HSLOpo | |
Modification date | 20200315 | 20200315 | |
UniProtAcc | . | Q12791 Main function of 5'-partner protein: FUNCTION: Potassium channel activated by both membrane depolarization or increase in cytosolic Ca(2+) that mediates export of K(+) (PubMed:29330545, PubMed:31152168). It is also activated by the concentration of cytosolic Mg(2+). Its activation dampens the excitatory events that elevate the cytosolic Ca(2+) concentration and/or depolarize the cell membrane. It therefore contributes to repolarization of the membrane potential. Plays a key role in controlling excitability in a number of systems, such as regulation of the contraction of smooth muscle, the tuning of hair cells in the cochlea, regulation of transmitter release, and innate immunity. In smooth muscles, its activation by high level of Ca(2+), caused by ryanodine receptors in the sarcoplasmic reticulum, regulates the membrane potential. In cochlea cells, its number and kinetic properties partly determine the characteristic frequency of each hair cell and thereby helps to establish a tonotopic map. Kinetics of KCNMA1 channels are determined by alternative splicing, phosphorylation status and its combination with modulating beta subunits. Highly sensitive to both iberiotoxin (IbTx) and charybdotoxin (CTX). {ECO:0000269|PubMed:29330545, ECO:0000269|PubMed:31152168}. | |
Ensembl transtripts involved in fusion gene | ENST ids | ENST00000344626, ENST00000358026, ENST00000413806, ENST00000429416, ENST00000444061, ENST00000450717, ENST00000541122, ENST00000589677, ENST00000590574, ENST00000538456, | ENST00000480683, ENST00000481070, ENST00000484507, ENST00000286627, ENST00000286628, ENST00000354353, ENST00000372440, ENST00000372443, ENST00000404771, ENST00000404857, ENST00000406533, |
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0) | * DoF score | 29 X 29 X 17=14297 | 18 X 17 X 8=2448 |
# samples | 55 | 21 | |
** MAII score | log2(55/14297*10)=-4.70013702309346 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(21/2448*10)=-3.54314232502653 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Fusion gene context | PubMed: SMARCA4 [Title/Abstract] AND KCNMA1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Fusion neoantigen context | PubMed: SMARCA4 [Title/Abstract] AND KCNMA1 [Title/Abstract] AND neoantigen [Title/Abstract] | ||
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | SMARCA4(11114074)-KCNMA1(79397104), # samples:1 | ||
Anticipated loss of major functional domain due to fusion event. | SMARCA4-KCNMA1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. SMARCA4-KCNMA1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. SMARCA4-KCNMA1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. SMARCA4-KCNMA1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | SMARCA4 | GO:0006337 | nucleosome disassembly | 8895581 |
Hgene | SMARCA4 | GO:0006338 | chromatin remodeling | 10943845|11726552 |
Hgene | SMARCA4 | GO:0045892 | negative regulation of transcription, DNA-templated | 12065415 |
Hgene | SMARCA4 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 15774904|17938176 |
Hgene | SMARCA4 | GO:0051091 | positive regulation of DNA-binding transcription factor activity | 11950834|17938176 |
Hgene | SMARCA4 | GO:1902661 | positive regulation of glucose mediated signaling pathway | 22368283 |
Tgene | KCNMA1 | GO:0001666 | response to hypoxia | 15528406 |
Tgene | KCNMA1 | GO:0006813 | potassium ion transport | 7573516|7877450|11245614|12388065|17706472|18458941 |
Tgene | KCNMA1 | GO:0006970 | response to osmotic stress | 10840032|12388065 |
Tgene | KCNMA1 | GO:0030007 | cellular potassium ion homeostasis | 11245614 |
Tgene | KCNMA1 | GO:0034465 | response to carbon monoxide | 15528406 |
Tgene | KCNMA1 | GO:0042391 | regulation of membrane potential | 7877450|7993625 |
Tgene | KCNMA1 | GO:0045794 | negative regulation of cell volume | 12388065 |
Tgene | KCNMA1 | GO:0051592 | response to calcium ion | 12388065|18458941 |
Tgene | KCNMA1 | GO:0060073 | micturition | 11641143 |
Tgene | KCNMA1 | GO:0060083 | smooth muscle contraction involved in micturition | 11641143 |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:11114074/chr10:79397104) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Fusion Amino Acid Sequences |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
ENST00000358026 | SMARCA4 | chr19 | 11114074 | + | ENST00000404771 | KCNMA1 | chr10 | 79397104 | + | 5998 | 2285 | 263 | 2350 | 695 |
ENST00000358026 | SMARCA4 | chr19 | 11114074 | + | ENST00000372440 | KCNMA1 | chr10 | 79397104 | + | 5795 | 2285 | 263 | 2350 | 695 |
ENST00000358026 | SMARCA4 | chr19 | 11114074 | + | ENST00000372443 | KCNMA1 | chr10 | 79397104 | + | 5879 | 2285 | 263 | 2353 | 696 |
ENST00000358026 | SMARCA4 | chr19 | 11114074 | + | ENST00000286628 | KCNMA1 | chr10 | 79397104 | + | 8085 | 2285 | 263 | 2311 | 682 |
ENST00000358026 | SMARCA4 | chr19 | 11114074 | + | ENST00000286627 | KCNMA1 | chr10 | 79397104 | + | 7911 | 2285 | 263 | 2311 | 682 |
ENST00000358026 | SMARCA4 | chr19 | 11114074 | + | ENST00000354353 | KCNMA1 | chr10 | 79397104 | + | 5709 | 2285 | 263 | 2311 | 682 |
ENST00000358026 | SMARCA4 | chr19 | 11114074 | + | ENST00000404857 | KCNMA1 | chr10 | 79397104 | + | 5649 | 2285 | 263 | 2311 | 682 |
ENST00000358026 | SMARCA4 | chr19 | 11114074 | + | ENST00000406533 | KCNMA1 | chr10 | 79397104 | + | 5712 | 2285 | 263 | 2311 | 682 |
ENST00000344626 | SMARCA4 | chr19 | 11114074 | + | ENST00000404771 | KCNMA1 | chr10 | 79397104 | + | 5919 | 2206 | 184 | 2271 | 695 |
ENST00000344626 | SMARCA4 | chr19 | 11114074 | + | ENST00000372440 | KCNMA1 | chr10 | 79397104 | + | 5716 | 2206 | 184 | 2271 | 695 |
ENST00000344626 | SMARCA4 | chr19 | 11114074 | + | ENST00000372443 | KCNMA1 | chr10 | 79397104 | + | 5800 | 2206 | 184 | 2274 | 696 |
ENST00000344626 | SMARCA4 | chr19 | 11114074 | + | ENST00000286628 | KCNMA1 | chr10 | 79397104 | + | 8006 | 2206 | 184 | 2232 | 682 |
ENST00000344626 | SMARCA4 | chr19 | 11114074 | + | ENST00000286627 | KCNMA1 | chr10 | 79397104 | + | 7832 | 2206 | 184 | 2232 | 682 |
ENST00000344626 | SMARCA4 | chr19 | 11114074 | + | ENST00000354353 | KCNMA1 | chr10 | 79397104 | + | 5630 | 2206 | 184 | 2232 | 682 |
ENST00000344626 | SMARCA4 | chr19 | 11114074 | + | ENST00000404857 | KCNMA1 | chr10 | 79397104 | + | 5570 | 2206 | 184 | 2232 | 682 |
ENST00000344626 | SMARCA4 | chr19 | 11114074 | + | ENST00000406533 | KCNMA1 | chr10 | 79397104 | + | 5633 | 2206 | 184 | 2232 | 682 |
ENST00000429416 | SMARCA4 | chr19 | 11114074 | + | ENST00000404771 | KCNMA1 | chr10 | 79397104 | + | 5995 | 2282 | 56 | 2347 | 763 |
ENST00000429416 | SMARCA4 | chr19 | 11114074 | + | ENST00000372440 | KCNMA1 | chr10 | 79397104 | + | 5792 | 2282 | 56 | 2347 | 763 |
ENST00000429416 | SMARCA4 | chr19 | 11114074 | + | ENST00000372443 | KCNMA1 | chr10 | 79397104 | + | 5876 | 2282 | 56 | 2350 | 764 |
ENST00000429416 | SMARCA4 | chr19 | 11114074 | + | ENST00000286628 | KCNMA1 | chr10 | 79397104 | + | 8082 | 2282 | 56 | 2308 | 750 |
ENST00000429416 | SMARCA4 | chr19 | 11114074 | + | ENST00000286627 | KCNMA1 | chr10 | 79397104 | + | 7908 | 2282 | 56 | 2308 | 750 |
ENST00000429416 | SMARCA4 | chr19 | 11114074 | + | ENST00000354353 | KCNMA1 | chr10 | 79397104 | + | 5706 | 2282 | 56 | 2308 | 750 |
ENST00000429416 | SMARCA4 | chr19 | 11114074 | + | ENST00000404857 | KCNMA1 | chr10 | 79397104 | + | 5646 | 2282 | 56 | 2308 | 750 |
ENST00000429416 | SMARCA4 | chr19 | 11114074 | + | ENST00000406533 | KCNMA1 | chr10 | 79397104 | + | 5709 | 2282 | 56 | 2308 | 750 |
ENST00000541122 | SMARCA4 | chr19 | 11114074 | + | ENST00000404771 | KCNMA1 | chr10 | 79397104 | + | 5999 | 2286 | 255 | 2351 | 698 |
ENST00000541122 | SMARCA4 | chr19 | 11114074 | + | ENST00000372440 | KCNMA1 | chr10 | 79397104 | + | 5796 | 2286 | 255 | 2351 | 698 |
ENST00000541122 | SMARCA4 | chr19 | 11114074 | + | ENST00000372443 | KCNMA1 | chr10 | 79397104 | + | 5880 | 2286 | 255 | 2354 | 699 |
ENST00000541122 | SMARCA4 | chr19 | 11114074 | + | ENST00000286628 | KCNMA1 | chr10 | 79397104 | + | 8086 | 2286 | 255 | 2312 | 685 |
ENST00000541122 | SMARCA4 | chr19 | 11114074 | + | ENST00000286627 | KCNMA1 | chr10 | 79397104 | + | 7912 | 2286 | 255 | 2312 | 685 |
ENST00000541122 | SMARCA4 | chr19 | 11114074 | + | ENST00000354353 | KCNMA1 | chr10 | 79397104 | + | 5710 | 2286 | 255 | 2312 | 685 |
ENST00000541122 | SMARCA4 | chr19 | 11114074 | + | ENST00000404857 | KCNMA1 | chr10 | 79397104 | + | 5650 | 2286 | 255 | 2312 | 685 |
ENST00000541122 | SMARCA4 | chr19 | 11114074 | + | ENST00000406533 | KCNMA1 | chr10 | 79397104 | + | 5713 | 2286 | 255 | 2312 | 685 |
ENST00000589677 | SMARCA4 | chr19 | 11114074 | + | ENST00000404771 | KCNMA1 | chr10 | 79397104 | + | 6044 | 2331 | 309 | 2396 | 695 |
ENST00000589677 | SMARCA4 | chr19 | 11114074 | + | ENST00000372440 | KCNMA1 | chr10 | 79397104 | + | 5841 | 2331 | 309 | 2396 | 695 |
ENST00000589677 | SMARCA4 | chr19 | 11114074 | + | ENST00000372443 | KCNMA1 | chr10 | 79397104 | + | 5925 | 2331 | 309 | 2399 | 696 |
ENST00000589677 | SMARCA4 | chr19 | 11114074 | + | ENST00000286628 | KCNMA1 | chr10 | 79397104 | + | 8131 | 2331 | 309 | 2357 | 682 |
ENST00000589677 | SMARCA4 | chr19 | 11114074 | + | ENST00000286627 | KCNMA1 | chr10 | 79397104 | + | 7957 | 2331 | 309 | 2357 | 682 |
ENST00000589677 | SMARCA4 | chr19 | 11114074 | + | ENST00000354353 | KCNMA1 | chr10 | 79397104 | + | 5755 | 2331 | 309 | 2357 | 682 |
ENST00000589677 | SMARCA4 | chr19 | 11114074 | + | ENST00000404857 | KCNMA1 | chr10 | 79397104 | + | 5695 | 2331 | 309 | 2357 | 682 |
ENST00000589677 | SMARCA4 | chr19 | 11114074 | + | ENST00000406533 | KCNMA1 | chr10 | 79397104 | + | 5758 | 2331 | 309 | 2357 | 682 |
ENST00000444061 | SMARCA4 | chr19 | 11114074 | + | ENST00000404771 | KCNMA1 | chr10 | 79397104 | + | 5810 | 2097 | 66 | 2162 | 698 |
ENST00000444061 | SMARCA4 | chr19 | 11114074 | + | ENST00000372440 | KCNMA1 | chr10 | 79397104 | + | 5607 | 2097 | 66 | 2162 | 698 |
ENST00000444061 | SMARCA4 | chr19 | 11114074 | + | ENST00000372443 | KCNMA1 | chr10 | 79397104 | + | 5691 | 2097 | 66 | 2165 | 699 |
ENST00000444061 | SMARCA4 | chr19 | 11114074 | + | ENST00000286628 | KCNMA1 | chr10 | 79397104 | + | 7897 | 2097 | 66 | 2123 | 685 |
ENST00000444061 | SMARCA4 | chr19 | 11114074 | + | ENST00000286627 | KCNMA1 | chr10 | 79397104 | + | 7723 | 2097 | 66 | 2123 | 685 |
ENST00000444061 | SMARCA4 | chr19 | 11114074 | + | ENST00000354353 | KCNMA1 | chr10 | 79397104 | + | 5521 | 2097 | 66 | 2123 | 685 |
ENST00000444061 | SMARCA4 | chr19 | 11114074 | + | ENST00000404857 | KCNMA1 | chr10 | 79397104 | + | 5461 | 2097 | 66 | 2123 | 685 |
ENST00000444061 | SMARCA4 | chr19 | 11114074 | + | ENST00000406533 | KCNMA1 | chr10 | 79397104 | + | 5524 | 2097 | 66 | 2123 | 685 |
ENST00000590574 | SMARCA4 | chr19 | 11114074 | + | ENST00000404771 | KCNMA1 | chr10 | 79397104 | + | 6151 | 2438 | 416 | 2503 | 695 |
ENST00000590574 | SMARCA4 | chr19 | 11114074 | + | ENST00000372440 | KCNMA1 | chr10 | 79397104 | + | 5948 | 2438 | 416 | 2503 | 695 |
ENST00000590574 | SMARCA4 | chr19 | 11114074 | + | ENST00000372443 | KCNMA1 | chr10 | 79397104 | + | 6032 | 2438 | 416 | 2506 | 696 |
ENST00000590574 | SMARCA4 | chr19 | 11114074 | + | ENST00000286628 | KCNMA1 | chr10 | 79397104 | + | 8238 | 2438 | 416 | 2464 | 682 |
ENST00000590574 | SMARCA4 | chr19 | 11114074 | + | ENST00000286627 | KCNMA1 | chr10 | 79397104 | + | 8064 | 2438 | 416 | 2464 | 682 |
ENST00000590574 | SMARCA4 | chr19 | 11114074 | + | ENST00000354353 | KCNMA1 | chr10 | 79397104 | + | 5862 | 2438 | 416 | 2464 | 682 |
ENST00000590574 | SMARCA4 | chr19 | 11114074 | + | ENST00000404857 | KCNMA1 | chr10 | 79397104 | + | 5802 | 2438 | 416 | 2464 | 682 |
ENST00000590574 | SMARCA4 | chr19 | 11114074 | + | ENST00000406533 | KCNMA1 | chr10 | 79397104 | + | 5865 | 2438 | 416 | 2464 | 682 |
ENST00000413806 | SMARCA4 | chr19 | 11114074 | + | ENST00000404771 | KCNMA1 | chr10 | 79397104 | + | 5714 | 2001 | 0 | 2066 | 688 |
ENST00000413806 | SMARCA4 | chr19 | 11114074 | + | ENST00000372440 | KCNMA1 | chr10 | 79397104 | + | 5511 | 2001 | 0 | 2066 | 688 |
ENST00000413806 | SMARCA4 | chr19 | 11114074 | + | ENST00000372443 | KCNMA1 | chr10 | 79397104 | + | 5595 | 2001 | 0 | 2069 | 689 |
ENST00000413806 | SMARCA4 | chr19 | 11114074 | + | ENST00000286628 | KCNMA1 | chr10 | 79397104 | + | 7801 | 2001 | 0 | 2027 | 675 |
ENST00000413806 | SMARCA4 | chr19 | 11114074 | + | ENST00000286627 | KCNMA1 | chr10 | 79397104 | + | 7627 | 2001 | 0 | 2027 | 675 |
ENST00000413806 | SMARCA4 | chr19 | 11114074 | + | ENST00000354353 | KCNMA1 | chr10 | 79397104 | + | 5425 | 2001 | 0 | 2027 | 675 |
ENST00000413806 | SMARCA4 | chr19 | 11114074 | + | ENST00000404857 | KCNMA1 | chr10 | 79397104 | + | 5365 | 2001 | 0 | 2027 | 675 |
ENST00000413806 | SMARCA4 | chr19 | 11114074 | + | ENST00000406533 | KCNMA1 | chr10 | 79397104 | + | 5428 | 2001 | 0 | 2027 | 675 |
ENST00000450717 | SMARCA4 | chr19 | 11114074 | + | ENST00000404771 | KCNMA1 | chr10 | 79397104 | + | 5714 | 2001 | 0 | 2066 | 688 |
ENST00000450717 | SMARCA4 | chr19 | 11114074 | + | ENST00000372440 | KCNMA1 | chr10 | 79397104 | + | 5511 | 2001 | 0 | 2066 | 688 |
ENST00000450717 | SMARCA4 | chr19 | 11114074 | + | ENST00000372443 | KCNMA1 | chr10 | 79397104 | + | 5595 | 2001 | 0 | 2069 | 689 |
ENST00000450717 | SMARCA4 | chr19 | 11114074 | + | ENST00000286628 | KCNMA1 | chr10 | 79397104 | + | 7801 | 2001 | 0 | 2027 | 675 |
ENST00000450717 | SMARCA4 | chr19 | 11114074 | + | ENST00000286627 | KCNMA1 | chr10 | 79397104 | + | 7627 | 2001 | 0 | 2027 | 675 |
ENST00000450717 | SMARCA4 | chr19 | 11114074 | + | ENST00000354353 | KCNMA1 | chr10 | 79397104 | + | 5425 | 2001 | 0 | 2027 | 675 |
ENST00000450717 | SMARCA4 | chr19 | 11114074 | + | ENST00000404857 | KCNMA1 | chr10 | 79397104 | + | 5365 | 2001 | 0 | 2027 | 675 |
ENST00000450717 | SMARCA4 | chr19 | 11114074 | + | ENST00000406533 | KCNMA1 | chr10 | 79397104 | + | 5428 | 2001 | 0 | 2027 | 675 |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
ENST00000358026 | ENST00000404771 | SMARCA4 | chr19 | 11114074 | + | KCNMA1 | chr10 | 79397104 | + | 0.007098464 | 0.9929015 |
ENST00000358026 | ENST00000372440 | SMARCA4 | chr19 | 11114074 | + | KCNMA1 | chr10 | 79397104 | + | 0.007554896 | 0.9924452 |
ENST00000358026 | ENST00000372443 | SMARCA4 | chr19 | 11114074 | + | KCNMA1 | chr10 | 79397104 | + | 0.007271536 | 0.9927285 |
ENST00000358026 | ENST00000286628 | SMARCA4 | chr19 | 11114074 | + | KCNMA1 | chr10 | 79397104 | + | 0.002543757 | 0.99745625 |
ENST00000358026 | ENST00000286627 | SMARCA4 | chr19 | 11114074 | + | KCNMA1 | chr10 | 79397104 | + | 0.002681246 | 0.9973188 |
ENST00000358026 | ENST00000354353 | SMARCA4 | chr19 | 11114074 | + | KCNMA1 | chr10 | 79397104 | + | 0.008907206 | 0.99109274 |
ENST00000358026 | ENST00000404857 | SMARCA4 | chr19 | 11114074 | + | KCNMA1 | chr10 | 79397104 | + | 0.008631992 | 0.991368 |
ENST00000358026 | ENST00000406533 | SMARCA4 | chr19 | 11114074 | + | KCNMA1 | chr10 | 79397104 | + | 0.008449574 | 0.99155045 |
ENST00000344626 | ENST00000404771 | SMARCA4 | chr19 | 11114074 | + | KCNMA1 | chr10 | 79397104 | + | 0.007333777 | 0.9926662 |
ENST00000344626 | ENST00000372440 | SMARCA4 | chr19 | 11114074 | + | KCNMA1 | chr10 | 79397104 | + | 0.007760081 | 0.99223995 |
ENST00000344626 | ENST00000372443 | SMARCA4 | chr19 | 11114074 | + | KCNMA1 | chr10 | 79397104 | + | 0.00746579 | 0.99253416 |
ENST00000344626 | ENST00000286628 | SMARCA4 | chr19 | 11114074 | + | KCNMA1 | chr10 | 79397104 | + | 0.002596081 | 0.9974039 |
ENST00000344626 | ENST00000286627 | SMARCA4 | chr19 | 11114074 | + | KCNMA1 | chr10 | 79397104 | + | 0.002737638 | 0.99726236 |
ENST00000344626 | ENST00000354353 | SMARCA4 | chr19 | 11114074 | + | KCNMA1 | chr10 | 79397104 | + | 0.009125917 | 0.99087405 |
ENST00000344626 | ENST00000404857 | SMARCA4 | chr19 | 11114074 | + | KCNMA1 | chr10 | 79397104 | + | 0.008744925 | 0.99125504 |
ENST00000344626 | ENST00000406533 | SMARCA4 | chr19 | 11114074 | + | KCNMA1 | chr10 | 79397104 | + | 0.00873274 | 0.99126726 |
ENST00000429416 | ENST00000404771 | SMARCA4 | chr19 | 11114074 | + | KCNMA1 | chr10 | 79397104 | + | 0.007711208 | 0.99228877 |
ENST00000429416 | ENST00000372440 | SMARCA4 | chr19 | 11114074 | + | KCNMA1 | chr10 | 79397104 | + | 0.008120786 | 0.99187917 |
ENST00000429416 | ENST00000372443 | SMARCA4 | chr19 | 11114074 | + | KCNMA1 | chr10 | 79397104 | + | 0.007835088 | 0.99216485 |
ENST00000429416 | ENST00000286628 | SMARCA4 | chr19 | 11114074 | + | KCNMA1 | chr10 | 79397104 | + | 0.002749821 | 0.99725014 |
ENST00000429416 | ENST00000286627 | SMARCA4 | chr19 | 11114074 | + | KCNMA1 | chr10 | 79397104 | + | 0.002872751 | 0.99712723 |
ENST00000429416 | ENST00000354353 | SMARCA4 | chr19 | 11114074 | + | KCNMA1 | chr10 | 79397104 | + | 0.009500177 | 0.9904998 |
ENST00000429416 | ENST00000404857 | SMARCA4 | chr19 | 11114074 | + | KCNMA1 | chr10 | 79397104 | + | 0.009111825 | 0.99088824 |
ENST00000429416 | ENST00000406533 | SMARCA4 | chr19 | 11114074 | + | KCNMA1 | chr10 | 79397104 | + | 0.009177711 | 0.9908223 |
ENST00000541122 | ENST00000404771 | SMARCA4 | chr19 | 11114074 | + | KCNMA1 | chr10 | 79397104 | + | 0.00736729 | 0.9926327 |
ENST00000541122 | ENST00000372440 | SMARCA4 | chr19 | 11114074 | + | KCNMA1 | chr10 | 79397104 | + | 0.00784375 | 0.99215627 |
ENST00000541122 | ENST00000372443 | SMARCA4 | chr19 | 11114074 | + | KCNMA1 | chr10 | 79397104 | + | 0.007551103 | 0.9924489 |
ENST00000541122 | ENST00000286628 | SMARCA4 | chr19 | 11114074 | + | KCNMA1 | chr10 | 79397104 | + | 0.002659297 | 0.99734074 |
ENST00000541122 | ENST00000286627 | SMARCA4 | chr19 | 11114074 | + | KCNMA1 | chr10 | 79397104 | + | 0.002802081 | 0.99719787 |
ENST00000541122 | ENST00000354353 | SMARCA4 | chr19 | 11114074 | + | KCNMA1 | chr10 | 79397104 | + | 0.009253886 | 0.99074614 |
ENST00000541122 | ENST00000404857 | SMARCA4 | chr19 | 11114074 | + | KCNMA1 | chr10 | 79397104 | + | 0.008899995 | 0.9911 |
ENST00000541122 | ENST00000406533 | SMARCA4 | chr19 | 11114074 | + | KCNMA1 | chr10 | 79397104 | + | 0.008842698 | 0.9911573 |
ENST00000589677 | ENST00000404771 | SMARCA4 | chr19 | 11114074 | + | KCNMA1 | chr10 | 79397104 | + | 0.006988196 | 0.9930118 |
ENST00000589677 | ENST00000372440 | SMARCA4 | chr19 | 11114074 | + | KCNMA1 | chr10 | 79397104 | + | 0.007350122 | 0.99264985 |
ENST00000589677 | ENST00000372443 | SMARCA4 | chr19 | 11114074 | + | KCNMA1 | chr10 | 79397104 | + | 0.00709869 | 0.99290127 |
ENST00000589677 | ENST00000286628 | SMARCA4 | chr19 | 11114074 | + | KCNMA1 | chr10 | 79397104 | + | 0.002596342 | 0.9974037 |
ENST00000589677 | ENST00000286627 | SMARCA4 | chr19 | 11114074 | + | KCNMA1 | chr10 | 79397104 | + | 0.002720566 | 0.99727947 |
ENST00000589677 | ENST00000354353 | SMARCA4 | chr19 | 11114074 | + | KCNMA1 | chr10 | 79397104 | + | 0.00862442 | 0.9913756 |
ENST00000589677 | ENST00000404857 | SMARCA4 | chr19 | 11114074 | + | KCNMA1 | chr10 | 79397104 | + | 0.008267848 | 0.9917321 |
ENST00000589677 | ENST00000406533 | SMARCA4 | chr19 | 11114074 | + | KCNMA1 | chr10 | 79397104 | + | 0.008275026 | 0.99172497 |
ENST00000444061 | ENST00000404771 | SMARCA4 | chr19 | 11114074 | + | KCNMA1 | chr10 | 79397104 | + | 0.00719622 | 0.99280375 |
ENST00000444061 | ENST00000372440 | SMARCA4 | chr19 | 11114074 | + | KCNMA1 | chr10 | 79397104 | + | 0.007594709 | 0.99240524 |
ENST00000444061 | ENST00000372443 | SMARCA4 | chr19 | 11114074 | + | KCNMA1 | chr10 | 79397104 | + | 0.007325073 | 0.9926749 |
ENST00000444061 | ENST00000286628 | SMARCA4 | chr19 | 11114074 | + | KCNMA1 | chr10 | 79397104 | + | 0.002530961 | 0.99746907 |
ENST00000444061 | ENST00000286627 | SMARCA4 | chr19 | 11114074 | + | KCNMA1 | chr10 | 79397104 | + | 0.002662066 | 0.9973379 |
ENST00000444061 | ENST00000354353 | SMARCA4 | chr19 | 11114074 | + | KCNMA1 | chr10 | 79397104 | + | 0.008893017 | 0.99110705 |
ENST00000444061 | ENST00000404857 | SMARCA4 | chr19 | 11114074 | + | KCNMA1 | chr10 | 79397104 | + | 0.008485828 | 0.9915141 |
ENST00000444061 | ENST00000406533 | SMARCA4 | chr19 | 11114074 | + | KCNMA1 | chr10 | 79397104 | + | 0.008572106 | 0.99142784 |
ENST00000590574 | ENST00000404771 | SMARCA4 | chr19 | 11114074 | + | KCNMA1 | chr10 | 79397104 | + | 0.00708214 | 0.99291784 |
ENST00000590574 | ENST00000372440 | SMARCA4 | chr19 | 11114074 | + | KCNMA1 | chr10 | 79397104 | + | 0.007471081 | 0.9925289 |
ENST00000590574 | ENST00000372443 | SMARCA4 | chr19 | 11114074 | + | KCNMA1 | chr10 | 79397104 | + | 0.007205923 | 0.9927941 |
ENST00000590574 | ENST00000286628 | SMARCA4 | chr19 | 11114074 | + | KCNMA1 | chr10 | 79397104 | + | 0.002585071 | 0.99741495 |
ENST00000590574 | ENST00000286627 | SMARCA4 | chr19 | 11114074 | + | KCNMA1 | chr10 | 79397104 | + | 0.00271236 | 0.99728763 |
ENST00000590574 | ENST00000354353 | SMARCA4 | chr19 | 11114074 | + | KCNMA1 | chr10 | 79397104 | + | 0.008780213 | 0.9912198 |
ENST00000590574 | ENST00000404857 | SMARCA4 | chr19 | 11114074 | + | KCNMA1 | chr10 | 79397104 | + | 0.008517019 | 0.9914829 |
ENST00000590574 | ENST00000406533 | SMARCA4 | chr19 | 11114074 | + | KCNMA1 | chr10 | 79397104 | + | 0.008460015 | 0.99154 |
ENST00000413806 | ENST00000404771 | SMARCA4 | chr19 | 11114074 | + | KCNMA1 | chr10 | 79397104 | + | 0.006974427 | 0.99302554 |
ENST00000413806 | ENST00000372440 | SMARCA4 | chr19 | 11114074 | + | KCNMA1 | chr10 | 79397104 | + | 0.007391208 | 0.9926087 |
ENST00000413806 | ENST00000372443 | SMARCA4 | chr19 | 11114074 | + | KCNMA1 | chr10 | 79397104 | + | 0.007108968 | 0.9928911 |
ENST00000413806 | ENST00000286628 | SMARCA4 | chr19 | 11114074 | + | KCNMA1 | chr10 | 79397104 | + | 0.002452772 | 0.9975472 |
ENST00000413806 | ENST00000286627 | SMARCA4 | chr19 | 11114074 | + | KCNMA1 | chr10 | 79397104 | + | 0.002580786 | 0.99741924 |
ENST00000413806 | ENST00000354353 | SMARCA4 | chr19 | 11114074 | + | KCNMA1 | chr10 | 79397104 | + | 0.008725932 | 0.99127406 |
ENST00000413806 | ENST00000404857 | SMARCA4 | chr19 | 11114074 | + | KCNMA1 | chr10 | 79397104 | + | 0.008339023 | 0.99166095 |
ENST00000413806 | ENST00000406533 | SMARCA4 | chr19 | 11114074 | + | KCNMA1 | chr10 | 79397104 | + | 0.008315111 | 0.9916849 |
ENST00000450717 | ENST00000404771 | SMARCA4 | chr19 | 11114074 | + | KCNMA1 | chr10 | 79397104 | + | 0.006974427 | 0.99302554 |
ENST00000450717 | ENST00000372440 | SMARCA4 | chr19 | 11114074 | + | KCNMA1 | chr10 | 79397104 | + | 0.007391208 | 0.9926087 |
ENST00000450717 | ENST00000372443 | SMARCA4 | chr19 | 11114074 | + | KCNMA1 | chr10 | 79397104 | + | 0.007108968 | 0.9928911 |
ENST00000450717 | ENST00000286628 | SMARCA4 | chr19 | 11114074 | + | KCNMA1 | chr10 | 79397104 | + | 0.002452772 | 0.9975472 |
ENST00000450717 | ENST00000286627 | SMARCA4 | chr19 | 11114074 | + | KCNMA1 | chr10 | 79397104 | + | 0.002580786 | 0.99741924 |
ENST00000450717 | ENST00000354353 | SMARCA4 | chr19 | 11114074 | + | KCNMA1 | chr10 | 79397104 | + | 0.008725932 | 0.99127406 |
ENST00000450717 | ENST00000404857 | SMARCA4 | chr19 | 11114074 | + | KCNMA1 | chr10 | 79397104 | + | 0.008339023 | 0.99166095 |
ENST00000450717 | ENST00000406533 | SMARCA4 | chr19 | 11114074 | + | KCNMA1 | chr10 | 79397104 | + | 0.008315111 | 0.9916849 |
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Get the fusion protein sequences from here. |
Fusion protein sequence information is available in the fasta format. >FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP |
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Fusion Protein Breakpoint Sequences for SMARCA4-KCNMA1 |
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Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | Length(fusion protein) | BP in fusion protein | Peptide |
SMARCA4 | chr19 | 11114074 | KCNMA1 | chr10 | 79397104 | 2282 | 23 | EEKRDAHSAPGPARRGGGGAGKSTAP |
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Potential FusionNeoAntigen Information of SMARCA4-KCNMA1 in HLA I |
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![]() * We used NetMHCpan v4.1 (%rank<0.5) and deepHLApan v1.1 (immunogenic score>0.5) |
Fusion gene | Hchr | Hbp | Tgene | Tchr | Tbp | HLA I | FusionNeoAntigen peptide | Binding score | Immunogenic score | Neoantigen start (at BP 13) | Neoantigen end (at BP 13) |
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Potential FusionNeoAntigen Information of SMARCA4-KCNMA1 in HLA II |
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![]() * We used NetMHCIIpan v4.1 (%rank<0.5). |
Fusion gene | Hchr | Hbp | Tgene | Tchr | Tbp | HLA II | FusionNeoAntigen peptide | Neoantigen start (at BP 13) | Neoantigen end (at BP 13) |
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Fusion breakpoint peptide structures of SMARCA4-KCNMA1 |
![]() * The minimum length of the amino acid sequence in RoseTTAFold is 14AA. Here, we predicted the 14AA fusion protein breakpoint sequence not the fusion neoantigen peptide, which is shorter than 14 AA. |
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Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D of SMARCA4-KCNMA1 |
![]() * We used Glide to predict the interaction between HLAs and neoantigens. |
HLA allele | PDB ID | File name | BPseq | Docking score | Glide score |
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Vaccine Design for the FusionNeoAntigens of SMARCA4-KCNMA1 |
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Fusion gene | Hchr | Hbp | Tchr | Tbp | Start in +/-13AA | End in +/-13AA | FusionNeoAntigen peptide sequence | FusionNeoAntigen RNA sequence |
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Fusion gene | Hchr | Hbp | Tchr | Tbp | Start in +/-13AA | End in +/-13AA | FusionNeoAntigen peptide | FusionNEoAntigen RNA sequence |
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Information of the samples that have these potential fusion neoantigens of SMARCA4-KCNMA1 |
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Cancer type | Fusion gene | Hchr | Hbp | Henst | Tchr | Tbp | Tenst | Sample |
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Potential target of CAR-T therapy development for SMARCA4-KCNMA1 |
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![]() * Minus value of BPloci means that the break point is located before the CDS. |
- In-frame and retained 'Transmembrane'. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Tgene | KCNMA1 | chr19:11114074 | chr10:79397104 | ENST00000286627 | 0 | 27 | 336_358 | 0 | 1179.0 | Intramembrane | Pore-forming%3B Name%3DP region | |
Tgene | KCNMA1 | chr19:11114074 | chr10:79397104 | ENST00000286628 | 0 | 28 | 336_358 | 0 | 1237.0 | Intramembrane | Pore-forming%3B Name%3DP region | |
Tgene | KCNMA1 | chr19:11114074 | chr10:79397104 | ENST00000404857 | 0 | 28 | 336_358 | 0 | 1220.0 | Intramembrane | Pore-forming%3B Name%3DP region | |
Tgene | KCNMA1 | chr19:11114074 | chr10:79397104 | ENST00000480683 | 0 | 2 | 336_358 | 0 | 169.0 | Intramembrane | Pore-forming%3B Name%3DP region | |
Tgene | KCNMA1 | chr19:11114074 | chr10:79397104 | ENST00000286627 | 0 | 27 | 179_199 | 0 | 1179.0 | Transmembrane | Helical%3B Name%3DSegment S1 | |
Tgene | KCNMA1 | chr19:11114074 | chr10:79397104 | ENST00000286627 | 0 | 27 | 215_235 | 0 | 1179.0 | Transmembrane | Helical%3B Name%3DSegment S2 | |
Tgene | KCNMA1 | chr19:11114074 | chr10:79397104 | ENST00000286627 | 0 | 27 | 240_260 | 0 | 1179.0 | Transmembrane | Helical%3B Name%3DSegment S3 | |
Tgene | KCNMA1 | chr19:11114074 | chr10:79397104 | ENST00000286627 | 0 | 27 | 265_285 | 0 | 1179.0 | Transmembrane | Helical%3B Name%3DSegment S4 | |
Tgene | KCNMA1 | chr19:11114074 | chr10:79397104 | ENST00000286627 | 0 | 27 | 301_321 | 0 | 1179.0 | Transmembrane | Helical%3B Name%3DSegment S5 | |
Tgene | KCNMA1 | chr19:11114074 | chr10:79397104 | ENST00000286627 | 0 | 27 | 368_388 | 0 | 1179.0 | Transmembrane | Helical%3B Name%3DSegment S6 | |
Tgene | KCNMA1 | chr19:11114074 | chr10:79397104 | ENST00000286627 | 0 | 27 | 87_107 | 0 | 1179.0 | Transmembrane | Helical%3B Name%3DSegment S0 | |
Tgene | KCNMA1 | chr19:11114074 | chr10:79397104 | ENST00000286628 | 0 | 28 | 179_199 | 0 | 1237.0 | Transmembrane | Helical%3B Name%3DSegment S1 | |
Tgene | KCNMA1 | chr19:11114074 | chr10:79397104 | ENST00000286628 | 0 | 28 | 215_235 | 0 | 1237.0 | Transmembrane | Helical%3B Name%3DSegment S2 | |
Tgene | KCNMA1 | chr19:11114074 | chr10:79397104 | ENST00000286628 | 0 | 28 | 240_260 | 0 | 1237.0 | Transmembrane | Helical%3B Name%3DSegment S3 | |
Tgene | KCNMA1 | chr19:11114074 | chr10:79397104 | ENST00000286628 | 0 | 28 | 265_285 | 0 | 1237.0 | Transmembrane | Helical%3B Name%3DSegment S4 | |
Tgene | KCNMA1 | chr19:11114074 | chr10:79397104 | ENST00000286628 | 0 | 28 | 301_321 | 0 | 1237.0 | Transmembrane | Helical%3B Name%3DSegment S5 | |
Tgene | KCNMA1 | chr19:11114074 | chr10:79397104 | ENST00000286628 | 0 | 28 | 368_388 | 0 | 1237.0 | Transmembrane | Helical%3B Name%3DSegment S6 | |
Tgene | KCNMA1 | chr19:11114074 | chr10:79397104 | ENST00000286628 | 0 | 28 | 87_107 | 0 | 1237.0 | Transmembrane | Helical%3B Name%3DSegment S0 | |
Tgene | KCNMA1 | chr19:11114074 | chr10:79397104 | ENST00000404857 | 0 | 28 | 179_199 | 0 | 1220.0 | Transmembrane | Helical%3B Name%3DSegment S1 | |
Tgene | KCNMA1 | chr19:11114074 | chr10:79397104 | ENST00000404857 | 0 | 28 | 215_235 | 0 | 1220.0 | Transmembrane | Helical%3B Name%3DSegment S2 | |
Tgene | KCNMA1 | chr19:11114074 | chr10:79397104 | ENST00000404857 | 0 | 28 | 240_260 | 0 | 1220.0 | Transmembrane | Helical%3B Name%3DSegment S3 | |
Tgene | KCNMA1 | chr19:11114074 | chr10:79397104 | ENST00000404857 | 0 | 28 | 265_285 | 0 | 1220.0 | Transmembrane | Helical%3B Name%3DSegment S4 | |
Tgene | KCNMA1 | chr19:11114074 | chr10:79397104 | ENST00000404857 | 0 | 28 | 301_321 | 0 | 1220.0 | Transmembrane | Helical%3B Name%3DSegment S5 | |
Tgene | KCNMA1 | chr19:11114074 | chr10:79397104 | ENST00000404857 | 0 | 28 | 368_388 | 0 | 1220.0 | Transmembrane | Helical%3B Name%3DSegment S6 | |
Tgene | KCNMA1 | chr19:11114074 | chr10:79397104 | ENST00000404857 | 0 | 28 | 87_107 | 0 | 1220.0 | Transmembrane | Helical%3B Name%3DSegment S0 | |
Tgene | KCNMA1 | chr19:11114074 | chr10:79397104 | ENST00000480683 | 0 | 2 | 179_199 | 0 | 169.0 | Transmembrane | Helical%3B Name%3DSegment S1 | |
Tgene | KCNMA1 | chr19:11114074 | chr10:79397104 | ENST00000480683 | 0 | 2 | 215_235 | 0 | 169.0 | Transmembrane | Helical%3B Name%3DSegment S2 | |
Tgene | KCNMA1 | chr19:11114074 | chr10:79397104 | ENST00000480683 | 0 | 2 | 240_260 | 0 | 169.0 | Transmembrane | Helical%3B Name%3DSegment S3 | |
Tgene | KCNMA1 | chr19:11114074 | chr10:79397104 | ENST00000480683 | 0 | 2 | 265_285 | 0 | 169.0 | Transmembrane | Helical%3B Name%3DSegment S4 | |
Tgene | KCNMA1 | chr19:11114074 | chr10:79397104 | ENST00000480683 | 0 | 2 | 301_321 | 0 | 169.0 | Transmembrane | Helical%3B Name%3DSegment S5 | |
Tgene | KCNMA1 | chr19:11114074 | chr10:79397104 | ENST00000480683 | 0 | 2 | 368_388 | 0 | 169.0 | Transmembrane | Helical%3B Name%3DSegment S6 | |
Tgene | KCNMA1 | chr19:11114074 | chr10:79397104 | ENST00000480683 | 0 | 2 | 87_107 | 0 | 169.0 | Transmembrane | Helical%3B Name%3DSegment S0 |
![]() * We used DeepLoc 1.0. The order of the X-axis of the barplot is as follows: Entry_ID, Localization, Type, Nucleus, Cytoplasm, Extracellular, Mitochondrion, Cell_membrane, Endoplasmic_reticulum, Plastid, Golgi.apparatus, Lysosome.Vacuole, Peroxisome. Y-axis is the output score of DeepLoc. Clicking the image will open a new tab with a large image. |
Hgene | Hchr | Hbp | Henst | Tgene | Tchr | Tbp | Tenst | DeepLoc result |
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Related Drugs to SMARCA4-KCNMA1 |
![]() (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
Hgene | Tgene | Drug | Source | PMID |
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Related Diseases to SMARCA4-KCNMA1 |
![]() (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
Hgene | Tgene | Disease | Source | PMID |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |