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Center for Computational Systems Medicine
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Fusion Gene and Fusion Protein Summary

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Fusion Amino Acid Sequences (multiple BPs and multiple gene isoforms)

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Fusion Protein Breakpoint Sequences - (for the Screening of the FusionNeoAntigens)

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Potential FusionNeoAntigens in HLA I - (netMHCpan v4.1 + deepHLApan v1.1)

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Potential FusionNeoAntigens in HLA II - (netMHCIIpan v4.1)

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Fusion Breakpoint 14 AA Peptide Structure - (RoseTTAFold)

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Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D - (Glide)

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Vaccine Design for the FusionNeoAntigens (RNA/protein sequences)

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Potential target of CAR-T therapy development

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Information on the samples that have these potential fusion neoantigens

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Fusion Protein Targeting Drugs - (Manual Curation)

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Fusion Protein Related diseases - (Manual Curation)

Fusion Protein:TCF7L2-CHD7

Fusion Gene and Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: TCF7L2-CHD7
FusionPDB ID: 89812
FusionGDB2.0 ID: 89812
HgeneTgene
Gene symbol

TCF7L2

CHD7

Gene ID

6934

55636

Gene nametranscription factor 7 like 2chromodomain helicase DNA binding protein 7
SynonymsTCF-4|TCF4CRG|HH5|IS3|KAL5
Cytomap

10q25.2-q25.3

8q12.2

Type of geneprotein-codingprotein-coding
Descriptiontranscription factor 7-like 2HMG box transcription factor 4T-cell factor 4T-cell-specific transcription factor 4hTCF-4transcription factor 7-like 2 (T-cell specific, HMG-box)chromodomain-helicase-DNA-binding protein 7ATP-dependent helicase CHD7CHARGE associationchromodomain helicase DNA binding protein 7 isoform CRA_e
Modification date2020031520200328
UniProtAcc

Q9NQB0

Main function of 5'-partner protein: FUNCTION: Participates in the Wnt signaling pathway and modulates MYC expression by binding to its promoter in a sequence-specific manner. Acts as repressor in the absence of CTNNB1, and as activator in its presence. Activates transcription from promoters with several copies of the Tcf motif 5'-CCTTTGATC-3' in the presence of CTNNB1. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7L2/TCF4 and CTNNB1. Expression of dominant-negative mutants results in cell-cycle arrest in G1. Necessary for the maintenance of the epithelial stem-cell compartment of the small intestine. {ECO:0000269|PubMed:12408868, ECO:0000269|PubMed:12727872, ECO:0000269|PubMed:19443654, ECO:0000269|PubMed:22699938, ECO:0000269|PubMed:9727977}.

Q9P2D1

Main function of 5'-partner protein: FUNCTION: Probable transcription regulator. Maybe involved in the in 45S precursor rRNA production. {ECO:0000269|PubMed:22646239}.
Ensembl transtripts involved in fusion geneENST idsENST00000349937, ENST00000352065, 
ENST00000355717, ENST00000355995, 
ENST00000369395, ENST00000369397, 
ENST00000534894, ENST00000536810, 
ENST00000538897, ENST00000543371, 
ENST00000545257, ENST00000542695, 
ENST00000369386, ENST00000369389, 
ENST00000466338, 		ENST00000529472, 
ENST00000423902, ENST00000524602, 
ENST00000525508, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score16 X 11 X 11=19369 X 5 X 6=270
# samples 239
** MAII scorelog2(23/1936*10)=-3.07337318633022
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/270*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Fusion gene context

PubMed: TCF7L2 [Title/Abstract] AND CHD7 [Title/Abstract] AND fusion [Title/Abstract]

Fusion neoantigen context

PubMed: TCF7L2 [Title/Abstract] AND CHD7 [Title/Abstract] AND neoantigen [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)CHD7(61655656)-TCF7L2(114900943), # samples:3
TCF7L2(114799885)-CHD7(61693559), # samples:3
Anticipated loss of major functional domain due to fusion event.CHD7-TCF7L2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CHD7-TCF7L2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
TCF7L2-CHD7 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
TCF7L2-CHD7 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
TCF7L2-CHD7 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
TCF7L2-CHD7 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTCF7L2

GO:0000122

negative regulation of transcription by RNA polymerase II

12799378

HgeneTCF7L2

GO:0006357

regulation of transcription by RNA polymerase II

9727977

HgeneTCF7L2

GO:0032092

positive regulation of protein binding

12799378

HgeneTCF7L2

GO:0032350

regulation of hormone metabolic process

15525634

HgeneTCF7L2

GO:0042593

glucose homeostasis

15525634

HgeneTCF7L2

GO:0043433

negative regulation of DNA-binding transcription factor activity

12799378

HgeneTCF7L2

GO:0045444

fat cell differentiation

10937998

HgeneTCF7L2

GO:0045892

negative regulation of transcription, DNA-templated

12799378|15525634

HgeneTCF7L2

GO:0045944

positive regulation of transcription by RNA polymerase II

9065401|19168596

HgeneTCF7L2

GO:0048625

myoblast fate commitment

10937998



check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:61655656/chr8:114900943)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonRetention analysis results of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features, are available here.

check buttonFusion gene breakpoints across TCF7L2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CHD7 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Amino Acid Sequences


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000534894TCF7L2chr10114799885+ENST00000423902CHD7chr861693559+9361105917783872736
ENST00000534894TCF7L2chr10114799885+ENST00000524602CHD7chr861693559+278210591772240687
ENST00000534894TCF7L2chr10114799885+ENST00000525508CHD7chr861693559+417110591772810877
ENST00000536810TCF7L2chr10114799885+ENST00000423902CHD7chr861693559+9361105917783872736
ENST00000536810TCF7L2chr10114799885+ENST00000524602CHD7chr861693559+278210591772240687
ENST00000536810TCF7L2chr10114799885+ENST00000525508CHD7chr861693559+417110591772810877
ENST00000545257TCF7L2chr10114799885+ENST00000423902CHD7chr861693559+9361105917783872736
ENST00000545257TCF7L2chr10114799885+ENST00000524602CHD7chr861693559+278210591772240687
ENST00000545257TCF7L2chr10114799885+ENST00000525508CHD7chr861693559+417110591772810877
ENST00000355995TCF7L2chr10114799885+ENST00000423902CHD7chr861693559+9361105917783872736
ENST00000355995TCF7L2chr10114799885+ENST00000524602CHD7chr861693559+278210591772240687
ENST00000355995TCF7L2chr10114799885+ENST00000525508CHD7chr861693559+417110591772810877
ENST00000543371TCF7L2chr10114799885+ENST00000423902CHD7chr861693559+9361105917783872736
ENST00000543371TCF7L2chr10114799885+ENST00000524602CHD7chr861693559+278210591772240687
ENST00000543371TCF7L2chr10114799885+ENST00000525508CHD7chr861693559+417110591772810877
ENST00000355717TCF7L2chr10114799885+ENST00000423902CHD7chr861693559+929299017783182713
ENST00000355717TCF7L2chr10114799885+ENST00000524602CHD7chr861693559+27139901772171664
ENST00000355717TCF7L2chr10114799885+ENST00000525508CHD7chr861693559+41029901772741854
ENST00000538897TCF7L2chr10114799885+ENST00000423902CHD7chr861693559+9361105917783872736
ENST00000538897TCF7L2chr10114799885+ENST00000524602CHD7chr861693559+278210591772240687
ENST00000538897TCF7L2chr10114799885+ENST00000525508CHD7chr861693559+417110591772810877
ENST00000349937TCF7L2chr10114799885+ENST00000423902CHD7chr861693559+91598573881852715
ENST00000349937TCF7L2chr10114799885+ENST00000524602CHD7chr861693559+2580857382038666
ENST00000349937TCF7L2chr10114799885+ENST00000525508CHD7chr861693559+3969857382608856
ENST00000369397TCF7L2chr10114799885+ENST00000423902CHD7chr861693559+90907883881162692
ENST00000369397TCF7L2chr10114799885+ENST00000524602CHD7chr861693559+2511788381969643
ENST00000369397TCF7L2chr10114799885+ENST00000525508CHD7chr861693559+3900788382539833
ENST00000352065TCF7L2chr10114799885+ENST00000423902CHD7chr861693559+88765741679022628
ENST00000352065TCF7L2chr10114799885+ENST00000524602CHD7chr861693559+2297574161755579
ENST00000352065TCF7L2chr10114799885+ENST00000525508CHD7chr861693559+3686574162325769
ENST00000369395TCF7L2chr10114799885+ENST00000423902CHD7chr861693559+88705681078962628
ENST00000369395TCF7L2chr10114799885+ENST00000524602CHD7chr861693559+2291568101749579
ENST00000369395TCF7L2chr10114799885+ENST00000525508CHD7chr861693559+3680568102319769

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000534894ENST00000423902TCF7L2chr10114799885+CHD7chr861693559+0.0009273930.99907255
ENST00000534894ENST00000524602TCF7L2chr10114799885+CHD7chr861693559+0.0012565610.9987435
ENST00000534894ENST00000525508TCF7L2chr10114799885+CHD7chr861693559+0.0008046330.9991954
ENST00000536810ENST00000423902TCF7L2chr10114799885+CHD7chr861693559+0.0009273930.99907255
ENST00000536810ENST00000524602TCF7L2chr10114799885+CHD7chr861693559+0.0012565610.9987435
ENST00000536810ENST00000525508TCF7L2chr10114799885+CHD7chr861693559+0.0008046330.9991954
ENST00000545257ENST00000423902TCF7L2chr10114799885+CHD7chr861693559+0.0009273930.99907255
ENST00000545257ENST00000524602TCF7L2chr10114799885+CHD7chr861693559+0.0012565610.9987435
ENST00000545257ENST00000525508TCF7L2chr10114799885+CHD7chr861693559+0.0008046330.9991954
ENST00000355995ENST00000423902TCF7L2chr10114799885+CHD7chr861693559+0.0009273930.99907255
ENST00000355995ENST00000524602TCF7L2chr10114799885+CHD7chr861693559+0.0012565610.9987435
ENST00000355995ENST00000525508TCF7L2chr10114799885+CHD7chr861693559+0.0008046330.9991954
ENST00000543371ENST00000423902TCF7L2chr10114799885+CHD7chr861693559+0.0009273930.99907255
ENST00000543371ENST00000524602TCF7L2chr10114799885+CHD7chr861693559+0.0012565610.9987435
ENST00000543371ENST00000525508TCF7L2chr10114799885+CHD7chr861693559+0.0008046330.9991954
ENST00000355717ENST00000423902TCF7L2chr10114799885+CHD7chr861693559+0.0009026530.99909735
ENST00000355717ENST00000524602TCF7L2chr10114799885+CHD7chr861693559+0.001459180.9985409
ENST00000355717ENST00000525508TCF7L2chr10114799885+CHD7chr861693559+0.0007984740.9992016
ENST00000538897ENST00000423902TCF7L2chr10114799885+CHD7chr861693559+0.0009273930.99907255
ENST00000538897ENST00000524602TCF7L2chr10114799885+CHD7chr861693559+0.0012565610.9987435
ENST00000538897ENST00000525508TCF7L2chr10114799885+CHD7chr861693559+0.0008046330.9991954
ENST00000349937ENST00000423902TCF7L2chr10114799885+CHD7chr861693559+0.0007614820.9992385
ENST00000349937ENST00000524602TCF7L2chr10114799885+CHD7chr861693559+0.0012994420.9987005
ENST00000349937ENST00000525508TCF7L2chr10114799885+CHD7chr861693559+0.0007639870.999236
ENST00000369397ENST00000423902TCF7L2chr10114799885+CHD7chr861693559+0.0007398280.9992601
ENST00000369397ENST00000524602TCF7L2chr10114799885+CHD7chr861693559+0.0014463690.9985536
ENST00000369397ENST00000525508TCF7L2chr10114799885+CHD7chr861693559+0.0007452690.99925476
ENST00000352065ENST00000423902TCF7L2chr10114799885+CHD7chr861693559+0.0006164090.99938357
ENST00000352065ENST00000524602TCF7L2chr10114799885+CHD7chr861693559+0.0014212570.9985788
ENST00000352065ENST00000525508TCF7L2chr10114799885+CHD7chr861693559+0.0008418340.99915814
ENST00000369395ENST00000423902TCF7L2chr10114799885+CHD7chr861693559+0.0006119960.999388
ENST00000369395ENST00000524602TCF7L2chr10114799885+CHD7chr861693559+0.0014413120.9985587
ENST00000369395ENST00000525508TCF7L2chr10114799885+CHD7chr861693559+0.0008485260.99915147

check button Predicted full-length fusion amino acid sequences. For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among all the predicted ones.

Get the fusion protein sequences from here.

Fusion protein sequence information is available in the fasta format.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

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Fusion Protein Breakpoint Sequences for TCF7L2-CHD7

check button +/-13 AA sequence from the breakpoints of the fusion protein sequences.
HgeneHchrHbpTgeneTchrTbpLength(fusion protein)BP in fusion proteinPeptide
TCF7L2chr10114799885CHD7chr8616935591059294LKDARSPSPAHIVHSPSEPFLEKPVP
TCF7L2chr10114799885CHD7chr8616935591059379ELNRNSLDGSQEEKKKKKRSKAKKDP
TCF7L2chr10114799885CHD7chr861693559568186LKDARSPSPAHIVHSPSEPFLEKPVP
TCF7L2chr10114799885CHD7chr861693559568271ELNRNSLDGSQEEKKKKKRSKAKKDP
TCF7L2chr10114799885CHD7chr861693559574186LKDARSPSPAHIVHSPSEPFLEKPVP
TCF7L2chr10114799885CHD7chr861693559574271ELNRNSLDGSQEEKKKKKRSKAKKDP
TCF7L2chr10114799885CHD7chr861693559788250LKDARSPSPAHIVHSPSEPFLEKPVP
TCF7L2chr10114799885CHD7chr861693559788335ELNRNSLDGSQEEKKKKKRSKAKKDP
TCF7L2chr10114799885CHD7chr861693559857273LKDARSPSPAHIVHSPSEPFLEKPVP
TCF7L2chr10114799885CHD7chr861693559857358ELNRNSLDGSQEEKKKKKRSKAKKDP
TCF7L2chr10114799885CHD7chr861693559990271LKDARSPSPAHIVHSPSEPFLEKPVP
TCF7L2chr10114799885CHD7chr861693559990356ELNRNSLDGSQEEKKKKKRSKAKKDP

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Potential FusionNeoAntigen Information of TCF7L2-CHD7 in HLA I

check button Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.

check button Potential FusionNeoAntigen Information
* We used NetMHCpan v4.1 (%rank<0.5) and deepHLApan v1.1 (immunogenic score>0.5)
Fusion geneHchrHbpTgeneTchrTbpHLA IFusionNeoAntigen peptideBinding scoreImmunogenic scoreNeoantigen start (at BP 13)Neoantigen end (at BP 13)

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Potential FusionNeoAntigen Information of TCF7L2-CHD7 in HLA II

check button Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.

check button Potential FusionNeoAntigen Information
* We used NetMHCIIpan v4.1 (%rank<0.5).
Fusion geneHchrHbpTgeneTchrTbpHLA IIFusionNeoAntigen peptideNeoantigen start (at BP 13)Neoantigen end (at BP 13)

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Fusion breakpoint peptide structures of TCF7L2-CHD7

check button3D structures of the fusion breakpoint peptide of 14AA sequence that have potential fusion neoantigens
* The minimum length of the amino acid sequence in RoseTTAFold is 14AA. Here, we predicted the 14AA fusion protein breakpoint sequence not the fusion neoantigen peptide, which is shorter than 14 AA.

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Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D of TCF7L2-CHD7

check buttonVirtual screening between 25 HLAs (from PDB) and FusionNeoAntigens
* We used Glide to predict the interaction between HLAs and neoantigens.
HLA allelePDB IDFile nameBPseqDocking scoreGlide score

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Vaccine Design for the FusionNeoAntigens of TCF7L2-CHD7

check button mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-Is.
Fusion geneHchrHbpTchrTbpStart in +/-13AAEnd in +/-13AAFusionNeoAntigen peptide sequenceFusionNeoAntigen RNA sequence

check button mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-IIs.
Fusion geneHchrHbpTchrTbpStart in +/-13AAEnd in +/-13AAFusionNeoAntigen peptideFusionNEoAntigen RNA sequence

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Information of the samples that have these potential fusion neoantigens of TCF7L2-CHD7

check button These samples were reported as having these fusion breakpoints. For individual breakpoints, we checked the open reading frames considering multiple gene isoforms and chose the in-frame fusion genes only. Then, we made fusion protein sequences and predicted the fusion neoantigens. These fusion-positive samples may have these potential fusion neoantigens.
Cancer typeFusion geneHchrHbpHenstTchrTbpTenstSample

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Potential target of CAR-T therapy development for TCF7L2-CHD7

check button Predicted 3D structure. We used RoseTTAFold.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, to provide the retention of the transmembrane domain, we only show the protein feature retention information of those transmembrane features


* Minus value of BPloci means that the break point is located before the CDS.
- In-frame and retained 'Transmembrane'.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

check button Subcellular localization prediction of the transmembrane domain retained fusion proteins
* We used DeepLoc 1.0. The order of the X-axis of the barplot is as follows: Entry_ID, Localization, Type, Nucleus, Cytoplasm, Extracellular, Mitochondrion, Cell_membrane, Endoplasmic_reticulum, Plastid, Golgi.apparatus, Lysosome.Vacuole, Peroxisome. Y-axis is the output score of DeepLoc. Clicking the image will open a new tab with a large image.
HgeneHchrHbpHenstTgeneTchrTbpTenstDeepLoc result

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Related Drugs to TCF7L2-CHD7

check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to TCF7L2-CHD7

check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTCF7L2C0036341Schizophrenia4PSYGENET
HgeneTCF7L2C0011860Diabetes Mellitus, Non-Insulin-Dependent3CTD_human
HgeneTCF7L2C0009402Colorectal Carcinoma2CTD_human;UNIPROT
HgeneTCF7L2C0009404Colorectal Neoplasms2CTD_human
HgeneTCF7L2C0001418Adenocarcinoma1CTD_human
HgeneTCF7L2C0005586Bipolar Disorder1PSYGENET
HgeneTCF7L2C0007102Malignant tumor of colon1CTD_human
HgeneTCF7L2C0007193Cardiomyopathy, Dilated1CTD_human
HgeneTCF7L2C0009375Colonic Neoplasms1CTD_human
HgeneTCF7L2C0010068Coronary heart disease1CTD_human
HgeneTCF7L2C0020507Hyperplasia1CTD_human
HgeneTCF7L2C0036337Schizoaffective Disorder1PSYGENET
HgeneTCF7L2C0087031Juvenile-Onset Still Disease1CTD_human
HgeneTCF7L2C0151744Myocardial Ischemia1CTD_human
HgeneTCF7L2C0205641Adenocarcinoma, Basal Cell1CTD_human
HgeneTCF7L2C0205642Adenocarcinoma, Oxyphilic1CTD_human
HgeneTCF7L2C0205643Carcinoma, Cribriform1CTD_human
HgeneTCF7L2C0205644Carcinoma, Granular Cell1CTD_human
HgeneTCF7L2C0205645Adenocarcinoma, Tubular1CTD_human
HgeneTCF7L2C0600519Ventricular Remodeling1CTD_human
HgeneTCF7L2C0600520Left Ventricle Remodeling1CTD_human
HgeneTCF7L2C1449563Cardiomyopathy, Familial Idiopathic1CTD_human
HgeneTCF7L2C1535926Neurodevelopmental Disorders1CTD_human
HgeneTCF7L2C2931456Prostate cancer, familial1CTD_human
HgeneTCF7L2C3495559Juvenile arthritis1CTD_human
HgeneTCF7L2C3714758Juvenile psoriatic arthritis1CTD_human
HgeneTCF7L2C4552091Polyarthritis, Juvenile, Rheumatoid Factor Negative1CTD_human
HgeneTCF7L2C4704862Polyarthritis, Juvenile, Rheumatoid Factor Positive1CTD_human
HgeneTCF7L2C4722327PROSTATE CANCER, HEREDITARY, 11CTD_human