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Center for Computational Systems Medicine
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Fusion Gene and Fusion Protein Summary

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Fusion Amino Acid Sequences (multiple BPs and multiple gene isoforms)

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Fusion Protein Breakpoint Sequences - (for the Screening of the FusionNeoAntigens)

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Potential FusionNeoAntigens in HLA I - (netMHCpan v4.1 + deepHLApan v1.1)

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Potential FusionNeoAntigens in HLA II - (netMHCIIpan v4.1)

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Fusion Breakpoint 14 AA Peptide Structure - (RoseTTAFold)

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Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D - (Glide)

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Vaccine Design for the FusionNeoAntigens (RNA/protein sequences)

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Potential target of CAR-T therapy development

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Information on the samples that have these potential fusion neoantigens

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Fusion Protein Targeting Drugs - (Manual Curation)

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Fusion Protein Related diseases - (Manual Curation)

Fusion Protein:TMPRSS2-ERG

Fusion Gene and Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: TMPRSS2-ERG
FusionPDB ID: 92377
FusionGDB2.0 ID: 92377
HgeneTgene
Gene symbol

TMPRSS2

ERG

Gene ID

7113

2078

Gene nametransmembrane serine protease 2ETS transcription factor ERG
SynonymsPP9284|PRSS10erg-3|p55
Cytomap

21q22.3

21q22.2

Type of geneprotein-codingprotein-coding
Descriptiontransmembrane protease serine 2epitheliasinserine protease 10transmembrane protease, serine 2transcriptional regulator ERGERG, ETS transcription factorFUS/ERG fusion proteinTMPRSS2/ERG fusionerythroblast transformation-specific transcription factor ERG variant 10ets-relatedtranscriptional regulator ERG (transforming protein ERG)v-ets avian
Modification date2020031320200320
UniProtAcc

O15393

Main function of 5'-partner protein: FUNCTION: Plasma membrane-anchored serine protease that participates in proteolytic cascades of relevance for the normal physiologic function of the prostate (PubMed:25122198). Androgen-induced TMPRSS2 activates several substrates that include pro-hepatocyte growth factor/HGF, the protease activated receptor-2/F2RL1 or matriptase/ST14 leading to extracellular matrix disruption and metastasis of prostate cancer cells (PubMed:15537383, PubMed:26018085, PubMed:25122198). In addition, activates trigeminal neurons and contribute to both spontaneous pain and mechanical allodynia (By similarity). {ECO:0000250|UniProtKB:Q9JIQ8, ECO:0000269|PubMed:15537383, ECO:0000269|PubMed:25122198, ECO:0000269|PubMed:26018085}.; FUNCTION: (Microbial infection) Facilitates human coronaviruses SARS-CoV and SARS-CoV-2 infections via two independent mechanisms, proteolytic cleavage of ACE2 receptor which promotes viral uptake, and cleavage of coronavirus spike glycoproteins which activates the glycoprotein for host cell entry (PubMed:24227843, PubMed:32142651, PubMed:32404436, PubMed:34159616, PubMed:33051876). Upon SARS-CoV-2 infection, increases syncytia formation by accelerating the fusion process (PubMed:34159616, PubMed:33051876). Proteolytically cleaves and activates the spike glycoproteins of human coronavirus 229E (HCoV-229E) and human coronavirus EMC (HCoV-EMC) and the fusion glycoproteins F0 of Sendai virus (SeV), human metapneumovirus (HMPV), human parainfluenza 1, 2, 3, 4a and 4b viruses (HPIV). Essential for spread and pathogenesis of influenza A virus (strains H1N1, H3N2 and H7N9); involved in proteolytic cleavage and activation of hemagglutinin (HA) protein which is essential for viral infectivity. {ECO:0000269|PubMed:21068237, ECO:0000269|PubMed:21325420, ECO:0000269|PubMed:23536651, ECO:0000269|PubMed:23966399, ECO:0000269|PubMed:24027332, ECO:0000269|PubMed:24227843, ECO:0000269|PubMed:32142651, ECO:0000269|PubMed:32404436, ECO:0000269|PubMed:33051876, ECO:0000269|PubMed:34159616}.

Q9Y282

Main function of 5'-partner protein: FUNCTION: Possible role in transport between endoplasmic reticulum and Golgi. {ECO:0000250}.
Ensembl transtripts involved in fusion geneENST idsENST00000332149, ENST00000398585, 
ENST00000458356, ENST00000497881, 
ENST00000398897, ENST00000398910, 
ENST00000398911, ENST00000398919, 
ENST00000417133, ENST00000429727, 
ENST00000442448, ENST00000453032, 
ENST00000485493, ENST00000288319, 
ENST00000398905, ENST00000398907, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score40 X 73 X 10=2920021 X 74 X 12=18648
# samples 13096
** MAII scorelog2(130/29200*10)=-4.48938484073892
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(96/18648*10)=-4.27984269352035
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Fusion gene context

PubMed: TMPRSS2 [Title/Abstract] AND ERG [Title/Abstract] AND fusion [Title/Abstract]

Recurrent fusion of TMPRSS2 and ETS transcription factor genes in prostate cancer (pmid: 16254181)
Fusion neoantigen context

PubMed: TMPRSS2 [Title/Abstract] AND ERG [Title/Abstract] AND neoantigen [Title/Abstract]

MicroRNA-regulated transcriptome analysis identifies four major subtypes with prognostic and therapeutic implications in prostate cancer.', 'Fusion transcripts and their genomic breakpoints in polyadenylated and ribosomal RNA-minus RNA sequencing data.', 'ProTECT-Prediction of T-Cell Epitopes for Cancer Therapy.' (pmid: 34527198, 34891161, 33244314)
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)TMPRSS2(42880008)-ERG(39817544), # samples:352
ERG(39947586)-TMPRSS2(42852529), # samples:5
Anticipated loss of major functional domain due to fusion event.ERG-TMPRSS2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ERG-TMPRSS2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
TMPRSS2-ERG seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
TMPRSS2-ERG seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
TMPRSS2-ERG seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
TMPRSS2-ERG seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ERG-TMPRSS2 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
ERG-TMPRSS2 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
ERG-TMPRSS2 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.
ERG-TMPRSS2 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
ERG-TMPRSS2 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
TMPRSS2-ERG seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
TMPRSS2-ERG seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
TMPRSS2-ERG seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
TMPRSS2-ERG seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
TMPRSS2-ERG seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTMPRSS2

GO:0006508

proteolysis

21068237|24227843

HgeneTMPRSS2

GO:0046598

positive regulation of viral entry into host cell

21068237|24227843

TgeneERG

GO:0045944

positive regulation of transcription by RNA polymerase II

18195090|23913826



check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr21:42880008/chr21:39817544)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonRetention analysis results of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features, are available here.

check buttonFusion gene breakpoints across TMPRSS2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ERG (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


Top

Fusion Amino Acid Sequences


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000458356TMPRSS2chr2142870045-ENST00000398907ERGchr2139795483-46151041441238364
ENST00000458356TMPRSS2chr2142870045-ENST00000398905ERGchr2139795483-46121041441235363
ENST00000458356TMPRSS2chr2142870045-ENST00000288319ERGchr2139795483-46841041441307387
ENST00000332149TMPRSS2chr2142870045-ENST00000398907ERGchr2139817544-48791501351502455
ENST00000332149TMPRSS2chr2142870045-ENST00000398905ERGchr2139817544-48761501351499454
ENST00000332149TMPRSS2chr2142870045-ENST00000288319ERGchr2139817544-49481501351571478
ENST00000398585TMPRSS2chr2142870045-ENST00000398907ERGchr2139817544-4916187401539499
ENST00000398585TMPRSS2chr2142870045-ENST00000398905ERGchr2139817544-4913187401536498
ENST00000398585TMPRSS2chr2142870045-ENST00000288319ERGchr2139817544-4985187401608522
ENST00000398585TMPRSS2chr2142879876-ENST00000398907ERGchr2139817544-4845116261468480
ENST00000398585TMPRSS2chr2142879876-ENST00000398905ERGchr2139817544-4842116261465479
ENST00000398585TMPRSS2chr2142879876-ENST00000288319ERGchr2139817544-4914116261537503
ENST00000458356TMPRSS2chr2142870046-ENST00000398907ERGchr2139795483-46151041441238364
ENST00000458356TMPRSS2chr2142870046-ENST00000398905ERGchr2139795483-46121041441235363
ENST00000458356TMPRSS2chr2142870046-ENST00000288319ERGchr2139795483-46841041441307387
ENST00000458356TMPRSS2chr2142866283-ENST00000398907ERGchr2139817544-50563273601679439
ENST00000458356TMPRSS2chr2142866283-ENST00000398905ERGchr2139817544-50533273601676438
ENST00000458356TMPRSS2chr2142866283-ENST00000288319ERGchr2139817544-51253273601748462
ENST00000332149TMPRSS2chr2142870046-ENST00000398907ERGchr2139817544-48791501351502455
ENST00000332149TMPRSS2chr2142870046-ENST00000398905ERGchr2139817544-48761501351499454
ENST00000332149TMPRSS2chr2142870046-ENST00000288319ERGchr2139817544-49481501351571478
ENST00000398585TMPRSS2chr2142870046-ENST00000398907ERGchr2139817544-4916187401539499
ENST00000398585TMPRSS2chr2142870046-ENST00000398905ERGchr2139817544-4913187401536498
ENST00000398585TMPRSS2chr2142870046-ENST00000288319ERGchr2139817544-4985187401608522
ENST00000458356TMPRSS2chr2142860321-ENST00000398907ERGchr2139817544-52635344891886465
ENST00000458356TMPRSS2chr2142860321-ENST00000398905ERGchr2139817544-52605344891883464
ENST00000458356TMPRSS2chr2142860321-ENST00000288319ERGchr2139817544-53325344891955488
ENST00000332149TMPRSS2chr2142870045-ENST00000398907ERGchr2139817544-48791501351502455
ENST00000332149TMPRSS2chr2142870045-ENST00000398905ERGchr2139817544-48761501351499454
ENST00000332149TMPRSS2chr2142870045-ENST00000288319ERGchr2139817544-49481501351571478
ENST00000398585TMPRSS2chr2142870045-ENST00000398907ERGchr2139817544-4916187401539499
ENST00000398585TMPRSS2chr2142870045-ENST00000398905ERGchr2139817544-4913187401536498
ENST00000398585TMPRSS2chr2142870045-ENST00000288319ERGchr2139817544-4985187401608522
ENST00000398585TMPRSS2chr2142879877-ENST00000398907ERGchr2139817544-4845116261468480
ENST00000398585TMPRSS2chr2142879877-ENST00000398905ERGchr2139817544-4842116261465479
ENST00000398585TMPRSS2chr2142879877-ENST00000288319ERGchr2139817544-4914116261537503
ENST00000332149TMPRSS2chr2142870045-ENST00000398907ERGchr2139817543-48791501351502455
ENST00000332149TMPRSS2chr2142870045-ENST00000398905ERGchr2139817543-48761501351499454
ENST00000332149TMPRSS2chr2142870045-ENST00000288319ERGchr2139817543-49481501351571478
ENST00000398585TMPRSS2chr2142870045-ENST00000398907ERGchr2139817543-4916187401539499
ENST00000398585TMPRSS2chr2142870045-ENST00000398905ERGchr2139817543-4913187401536498
ENST00000398585TMPRSS2chr2142870045-ENST00000288319ERGchr2139817543-4985187401608522
ENST00000398585TMPRSS2chr2142879876-ENST00000398907ERGchr2139817543-4845116261468480
ENST00000398585TMPRSS2chr2142879876-ENST00000398905ERGchr2139817543-4842116261465479
ENST00000398585TMPRSS2chr2142879876-ENST00000288319ERGchr2139817543-4914116261537503
ENST00000458356TMPRSS2chr2142866282-ENST00000398907ERGchr2139817543-50563273601679439
ENST00000458356TMPRSS2chr2142866282-ENST00000398905ERGchr2139817543-50533273601676438
ENST00000458356TMPRSS2chr2142866282-ENST00000288319ERGchr2139817543-51253273601748462
ENST00000458356TMPRSS2chr2142860320-ENST00000398907ERGchr2139817543-52635344891886465
ENST00000458356TMPRSS2chr2142860320-ENST00000398905ERGchr2139817543-52605344891883464
ENST00000458356TMPRSS2chr2142860320-ENST00000288319ERGchr2139817543-53325344891955488
ENST00000458356TMPRSS2chr2142870045-ENST00000398907ERGchr2139795482-46151041441238364
ENST00000458356TMPRSS2chr2142870045-ENST00000398905ERGchr2139795482-46121041441235363
ENST00000458356TMPRSS2chr2142870045-ENST00000288319ERGchr2139795482-46841041441307387
ENST00000332149TMPRSS2chr2142870044-ENST00000398907ERGchr2139817542-48791501351502455
ENST00000332149TMPRSS2chr2142870044-ENST00000398905ERGchr2139817542-48761501351499454
ENST00000332149TMPRSS2chr2142870044-ENST00000288319ERGchr2139817542-49481501351571478
ENST00000398585TMPRSS2chr2142870044-ENST00000398907ERGchr2139817542-4916187401539499
ENST00000398585TMPRSS2chr2142870044-ENST00000398905ERGchr2139817542-4913187401536498
ENST00000398585TMPRSS2chr2142870044-ENST00000288319ERGchr2139817542-4985187401608522
ENST00000332149TMPRSS2chr2142870045-ENST00000398907ERGchr2139817542-48791501351502455
ENST00000332149TMPRSS2chr2142870045-ENST00000398905ERGchr2139817542-48761501351499454
ENST00000332149TMPRSS2chr2142870045-ENST00000288319ERGchr2139817542-49481501351571478
ENST00000398585TMPRSS2chr2142870045-ENST00000398907ERGchr2139817542-4916187401539499
ENST00000398585TMPRSS2chr2142870045-ENST00000398905ERGchr2139817542-4913187401536498
ENST00000398585TMPRSS2chr2142870045-ENST00000288319ERGchr2139817542-4985187401608522
ENST00000398585TMPRSS2chr2142879875-ENST00000398907ERGchr2139817542-4845116261468480
ENST00000398585TMPRSS2chr2142879875-ENST00000398905ERGchr2139817542-4842116261465479
ENST00000398585TMPRSS2chr2142879875-ENST00000288319ERGchr2139817542-4914116261537503

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000458356ENST00000398907TMPRSS2chr2142870046-ERGchr2139795483-0.00195290.9980471
ENST00000458356ENST00000398905TMPRSS2chr2142870046-ERGchr2139795483-0.0026219060.9973781
ENST00000458356ENST00000288319TMPRSS2chr2142870046-ERGchr2139795483-0.00294620.99705374
ENST00000458356ENST00000398907TMPRSS2chr2142866283-ERGchr2139817544-0.0014636850.99853635
ENST00000458356ENST00000398905TMPRSS2chr2142866283-ERGchr2139817544-0.0018750790.9981249
ENST00000458356ENST00000288319TMPRSS2chr2142866283-ERGchr2139817544-0.0019518330.9980482
ENST00000332149ENST00000398907TMPRSS2chr2142870046-ERGchr2139817544-0.0017219780.998278
ENST00000332149ENST00000398905TMPRSS2chr2142870046-ERGchr2139817544-0.002092820.99790716
ENST00000332149ENST00000288319TMPRSS2chr2142870046-ERGchr2139817544-0.0021258180.99787414
ENST00000398585ENST00000398907TMPRSS2chr2142870046-ERGchr2139817544-0.0011388440.9988612
ENST00000398585ENST00000398905TMPRSS2chr2142870046-ERGchr2139817544-0.0009845610.99901545
ENST00000398585ENST00000288319TMPRSS2chr2142870046-ERGchr2139817544-0.0012755740.9987244
ENST00000458356ENST00000398907TMPRSS2chr2142860321-ERGchr2139817544-0.0024374510.9975625
ENST00000458356ENST00000398905TMPRSS2chr2142860321-ERGchr2139817544-0.0027176280.9972824
ENST00000458356ENST00000288319TMPRSS2chr2142860321-ERGchr2139817544-0.002197170.9978028
ENST00000332149ENST00000398907TMPRSS2chr2142870045-ERGchr2139817544-0.0017219780.998278
ENST00000332149ENST00000398905TMPRSS2chr2142870045-ERGchr2139817544-0.002092820.99790716
ENST00000332149ENST00000288319TMPRSS2chr2142870045-ERGchr2139817544-0.0021258180.99787414
ENST00000398585ENST00000398907TMPRSS2chr2142870045-ERGchr2139817544-0.0011388440.9988612
ENST00000398585ENST00000398905TMPRSS2chr2142870045-ERGchr2139817544-0.0009845610.99901545
ENST00000398585ENST00000288319TMPRSS2chr2142870045-ERGchr2139817544-0.0012755740.9987244
ENST00000398585ENST00000398907TMPRSS2chr2142879877-ERGchr2139817544-0.0014122120.99858785
ENST00000398585ENST00000398905TMPRSS2chr2142879877-ERGchr2139817544-0.0018070290.99819297
ENST00000398585ENST00000288319TMPRSS2chr2142879877-ERGchr2139817544-0.0018772180.99812275
ENST00000332149ENST00000398907TMPRSS2chr2142870045-ERGchr2139817543-0.0017219780.998278
ENST00000332149ENST00000398905TMPRSS2chr2142870045-ERGchr2139817543-0.002092820.99790716
ENST00000332149ENST00000288319TMPRSS2chr2142870045-ERGchr2139817543-0.0021258180.99787414
ENST00000398585ENST00000398907TMPRSS2chr2142870045-ERGchr2139817543-0.0011388440.9988612
ENST00000398585ENST00000398905TMPRSS2chr2142870045-ERGchr2139817543-0.0009845610.99901545
ENST00000398585ENST00000288319TMPRSS2chr2142870045-ERGchr2139817543-0.0012755740.9987244
ENST00000398585ENST00000398907TMPRSS2chr2142879876-ERGchr2139817543-0.0014122120.99858785
ENST00000398585ENST00000398905TMPRSS2chr2142879876-ERGchr2139817543-0.0018070290.99819297
ENST00000398585ENST00000288319TMPRSS2chr2142879876-ERGchr2139817543-0.0018772180.99812275
ENST00000458356ENST00000398907TMPRSS2chr2142866282-ERGchr2139817543-0.0014636850.99853635
ENST00000458356ENST00000398905TMPRSS2chr2142866282-ERGchr2139817543-0.0018750790.9981249
ENST00000458356ENST00000288319TMPRSS2chr2142866282-ERGchr2139817543-0.0019518330.9980482
ENST00000458356ENST00000398907TMPRSS2chr2142860320-ERGchr2139817543-0.0024374510.9975625
ENST00000458356ENST00000398905TMPRSS2chr2142860320-ERGchr2139817543-0.0027176280.9972824
ENST00000458356ENST00000288319TMPRSS2chr2142860320-ERGchr2139817543-0.002197170.9978028
ENST00000458356ENST00000398907TMPRSS2chr2142870045-ERGchr2139795482-0.00195290.9980471
ENST00000458356ENST00000398905TMPRSS2chr2142870045-ERGchr2139795482-0.0026219060.9973781
ENST00000458356ENST00000288319TMPRSS2chr2142870045-ERGchr2139795482-0.00294620.99705374
ENST00000332149ENST00000398907TMPRSS2chr2142870044-ERGchr2139817542-0.0017219780.998278
ENST00000332149ENST00000398905TMPRSS2chr2142870044-ERGchr2139817542-0.002092820.99790716
ENST00000332149ENST00000288319TMPRSS2chr2142870044-ERGchr2139817542-0.0021258180.99787414
ENST00000398585ENST00000398907TMPRSS2chr2142870044-ERGchr2139817542-0.0011388440.9988612
ENST00000398585ENST00000398905TMPRSS2chr2142870044-ERGchr2139817542-0.0009845610.99901545
ENST00000398585ENST00000288319TMPRSS2chr2142870044-ERGchr2139817542-0.0012755740.9987244
ENST00000332149ENST00000398907TMPRSS2chr2142870045-ERGchr2139817542-0.0017219780.998278
ENST00000332149ENST00000398905TMPRSS2chr2142870045-ERGchr2139817542-0.002092820.99790716
ENST00000332149ENST00000288319TMPRSS2chr2142870045-ERGchr2139817542-0.0021258180.99787414
ENST00000398585ENST00000398907TMPRSS2chr2142870045-ERGchr2139817542-0.0011388440.9988612
ENST00000398585ENST00000398905TMPRSS2chr2142870045-ERGchr2139817542-0.0009845610.99901545
ENST00000398585ENST00000288319TMPRSS2chr2142870045-ERGchr2139817542-0.0012755740.9987244
ENST00000398585ENST00000398907TMPRSS2chr2142879875-ERGchr2139817542-0.0014122120.99858785
ENST00000398585ENST00000398905TMPRSS2chr2142879875-ERGchr2139817542-0.0018070290.99819297
ENST00000398585ENST00000288319TMPRSS2chr2142879875-ERGchr2139817542-0.0018772180.99812275

check button Predicted full-length fusion amino acid sequences. For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among all the predicted ones.

Get the fusion protein sequences from here.

Fusion protein sequence information is available in the fasta format.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

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Fusion Protein Breakpoint Sequences for TMPRSS2-ERG

check button +/-13 AA sequence from the breakpoints of the fusion protein sequences.
HgeneHchrHbpTgeneTchrTbpLength(fusion protein)BP in fusion proteinPeptide
TMPRSS2chr2142860320ERGchr213981754353415CHTAPAGRTRIGVEALSVVSEDQSLF
TMPRSS2chr2142860321ERGchr213981754453415CHTAPAGRTRIGVEALSVVSEDQSLF
TMPRSS2chr2142870044ERGchr213981754218749LDAVDNSKMALNSEALSVVSEDQSLF
TMPRSS2chr2142870045ERGchr213981754218749LDAVDNSKMALNSEALSVVSEDQSLF
TMPRSS2chr2142870045ERGchr213981754318749LDAVDNSKMALNSEALSVVSEDQSLF
TMPRSS2chr2142870045ERGchr213981754418749LDAVDNSKMALNSEALSVVSEDQSLF
TMPRSS2chr2142870046ERGchr213981754418749LDAVDNSKMALNSEALSVVSEDQSLF
TMPRSS2chr2142879875ERGchr213981754211629RPEVKAGVRSAARQEALSVVSEDQSL
TMPRSS2chr2142879876ERGchr213981754311629RPEVKAGVRSAARQEALSVVSEDQSL
TMPRSS2chr2142879876ERGchr213981754411629RPEVKAGVRSAARQEALSVVSEDQSL
TMPRSS2chr2142879877ERGchr213981754411629RPEVKAGVRSAARQEALSVVSEDQSL

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Potential FusionNeoAntigen Information of TMPRSS2-ERG in HLA I

check button Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.
TMPRSS2-ERG_42860320_39817543.msa
TMPRSS2-ERG_42870044_39817542.msa
TMPRSS2-ERG_42879875_39817542.msa

check button Potential FusionNeoAntigen Information
* We used NetMHCpan v4.1 (%rank<0.5) and deepHLApan v1.1 (immunogenic score>0.5)
Fusion geneHchrHbpTgeneTchrTbpHLA IFusionNeoAntigen peptideBinding scoreImmunogenic scoreNeoantigen start (at BP 13)Neoantigen end (at BP 13)
TMPRSS2-ERGchr2142860320chr2139817543534HLA-B39:24TRIGVEAL0.99990.5098816
TMPRSS2-ERGchr2142860320chr2139817543534HLA-B39:06TRIGVEAL0.99980.8094816
TMPRSS2-ERGchr2142860320chr2139817543534HLA-B39:01TRIGVEAL0.99980.8961816
TMPRSS2-ERGchr2142860320chr2139817543534HLA-B14:02TRIGVEAL0.99960.8803816
TMPRSS2-ERGchr2142860320chr2139817543534HLA-B14:01TRIGVEAL0.99960.8803816
TMPRSS2-ERGchr2142860320chr2139817543534HLA-B15:10TRIGVEAL0.99930.6829816
TMPRSS2-ERGchr2142860320chr2139817543534HLA-B15:37TRIGVEAL0.99760.72816
TMPRSS2-ERGchr2142860320chr2139817543534HLA-B07:10RTRIGVEAL0.9970.5712716
TMPRSS2-ERGchr2142860320chr2139817543534HLA-B07:02RTRIGVEAL0.99670.5227716
TMPRSS2-ERGchr2142860320chr2139817543534HLA-A30:08RTRIGVEAL0.99180.8615716
TMPRSS2-ERGchr2142860320chr2139817543534HLA-B15:17RTRIGVEAL0.98430.9457716
TMPRSS2-ERGchr2142860320chr2139817543534HLA-B39:06GRTRIGVEA0.94540.7663615
TMPRSS2-ERGchr2142860320chr2139817543534HLA-B27:07TRIGVEALSV0.99980.7792818
TMPRSS2-ERGchr2142860320chr2139817543534HLA-B27:04GRTRIGVEAL0.99960.825616
TMPRSS2-ERGchr2142860320chr2139817543534HLA-B27:07GRTRIGVEAL0.99920.5613616
TMPRSS2-ERGchr2142860320chr2139817543534HLA-A30:08RTRIGVEALSV0.9990.8781718
TMPRSS2-ERGchr2142860320chr2139817543534HLA-B39:09TRIGVEAL0.99980.7644816
TMPRSS2-ERGchr2142860320chr2139817543534HLA-B39:12TRIGVEAL0.99970.904816
TMPRSS2-ERGchr2142860320chr2139817543534HLA-B39:05TRIGVEAL0.99950.8828816
TMPRSS2-ERGchr2142860320chr2139817543534HLA-B14:03TRIGVEAL0.97460.8208816
TMPRSS2-ERGchr2142860320chr2139817543534HLA-B27:14GRTRIGVEA0.9990.6698615
TMPRSS2-ERGchr2142860320chr2139817543534HLA-C15:06RTRIGVEAL0.99610.9531716
TMPRSS2-ERGchr2142860320chr2139817543534HLA-B73:01GRTRIGVEA0.99050.7287615
TMPRSS2-ERGchr2142860320chr2139817543534HLA-B07:12RTRIGVEAL0.9870.6862716
TMPRSS2-ERGchr2142860320chr2139817543534HLA-B07:04RTRIGVEAL0.98160.6013716
TMPRSS2-ERGchr2142860320chr2139817543534HLA-C03:08RTRIGVEAL0.97890.9409716
TMPRSS2-ERGchr2142860320chr2139817543534HLA-B73:01TRIGVEALS0.9470.6997817
TMPRSS2-ERGchr2142860320chr2139817543534HLA-B27:14TRIGVEALSV0.99990.8258818
TMPRSS2-ERGchr2142860320chr2139817543534HLA-B73:01TRIGVEALSV0.99770.8508818
TMPRSS2-ERGchr2142860320chr2139817543534HLA-B39:31TRIGVEAL0.99980.8972816
TMPRSS2-ERGchr2142860320chr2139817543534HLA-B15:09TRIGVEAL0.99850.8525816
TMPRSS2-ERGchr2142860320chr2139817543534HLA-B07:09RTRIGVEAL0.99690.5226716
TMPRSS2-ERGchr2142860320chr2139817543534HLA-B07:22RTRIGVEAL0.99670.5227716
TMPRSS2-ERGchr2142860320chr2139817543534HLA-B07:13RTRIGVEAL0.9930.8814716
TMPRSS2-ERGchr2142860320chr2139817543534HLA-A30:01RTRIGVEAL0.99260.9322716
TMPRSS2-ERGchr2142860320chr2139817543534HLA-A32:01RTRIGVEAL0.97550.9626716
TMPRSS2-ERGchr2142860320chr2139817543534HLA-B15:73RTRIGVEAL0.90490.9623716
TMPRSS2-ERGchr2142860320chr2139817543534HLA-B15:30RTRIGVEAL0.85970.9374716
TMPRSS2-ERGchr2142860320chr2139817543534HLA-B07:26RTRIGVEAL0.85710.5142716
TMPRSS2-ERGchr2142860320chr2139817543534HLA-B27:09TRIGVEALSV0.99990.8665818
TMPRSS2-ERGchr2142860320chr2139817543534HLA-B27:06TRIGVEALSV0.99980.8794818
TMPRSS2-ERGchr2142860320chr2139817543534HLA-B27:08GRTRIGVEAL0.99970.6634616
TMPRSS2-ERGchr2142860320chr2139817543534HLA-B27:06GRTRIGVEAL0.99930.8215616
TMPRSS2-ERGchr2142860320chr2139817543534HLA-B27:09GRTRIGVEAL0.99910.7303616
TMPRSS2-ERGchr2142870044chr2139817542187HLA-A02:22ALNSEALSV0.9990.5989918
TMPRSS2-ERGchr2142870044chr2139817542187HLA-A02:13ALNSEALSV0.99850.7545918
TMPRSS2-ERGchr2142870044chr2139817542187HLA-A02:27ALNSEALSV0.99850.6994918
TMPRSS2-ERGchr2142870044chr2139817542187HLA-A02:38ALNSEALSV0.99840.7207918
TMPRSS2-ERGchr2142870044chr2139817542187HLA-A02:11ALNSEALSV0.99810.6676918
TMPRSS2-ERGchr2142870044chr2139817542187HLA-A02:16ALNSEALSV0.9980.5382918
TMPRSS2-ERGchr2142870044chr2139817542187HLA-A02:60ALNSEALSV0.9980.5605918
TMPRSS2-ERGchr2142870044chr2139817542187HLA-A02:30ALNSEALSV0.9980.6392918
TMPRSS2-ERGchr2142870044chr2139817542187HLA-A02:24ALNSEALSV0.9980.6392918
TMPRSS2-ERGchr2142870044chr2139817542187HLA-A02:67ALNSEALSV0.9980.6392918
TMPRSS2-ERGchr2142870044chr2139817542187HLA-A02:21ALNSEALSV0.99780.7731918
TMPRSS2-ERGchr2142870044chr2139817542187HLA-A02:19ALNSEALSV0.99430.5282918
TMPRSS2-ERGchr2142870044chr2139817542187HLA-A02:04ALNSEALSV0.99430.5738918
TMPRSS2-ERGchr2142870044chr2139817542187HLA-B39:06SKMALNSEA0.99410.7038615
TMPRSS2-ERGchr2142870044chr2139817542187HLA-A02:35ALNSEALSV0.97650.681918
TMPRSS2-ERGchr2142870044chr2139817542187HLA-A02:29ALNSEALSV0.93550.6439918
TMPRSS2-ERGchr2142870044chr2139817542187HLA-A02:20ALNSEALSV0.92040.6446918
TMPRSS2-ERGchr2142870044chr2139817542187HLA-B13:02ALNSEALSV0.08470.6397918
TMPRSS2-ERGchr2142870044chr2139817542187HLA-A02:22ALNSEALSVV0.99890.6437919
TMPRSS2-ERGchr2142870044chr2139817542187HLA-A02:13ALNSEALSVV0.99780.78919
TMPRSS2-ERGchr2142870044chr2139817542187HLA-A02:27ALNSEALSVV0.99750.7133919
TMPRSS2-ERGchr2142870044chr2139817542187HLA-A02:16ALNSEALSVV0.99530.583919
TMPRSS2-ERGchr2142870044chr2139817542187HLA-A02:11ALNSEALSVV0.99480.6608919
TMPRSS2-ERGchr2142870044chr2139817542187HLA-A02:38ALNSEALSVV0.99010.7615919
TMPRSS2-ERGchr2142870044chr2139817542187HLA-A02:19ALNSEALSVV0.9890.5105919
TMPRSS2-ERGchr2142870044chr2139817542187HLA-A02:01ALNSEALSV0.9980.6392918
TMPRSS2-ERGchr2142870044chr2139817542187HLA-A02:07ALNSEALSV0.9980.6521918
TMPRSS2-ERGchr2142870044chr2139817542187HLA-B35:22MALNSEAL0.99140.5286816
TMPRSS2-ERGchr2142870044chr2139817542187HLA-B35:13MALNSEAL0.98180.9276816
TMPRSS2-ERGchr2142870044chr2139817542187HLA-A02:03ALNSEALSV0.99920.7248918
TMPRSS2-ERGchr2142870044chr2139817542187HLA-A02:06ALNSEALSV0.99780.7731918
TMPRSS2-ERGchr2142870044chr2139817542187HLA-A02:14ALNSEALSV0.99780.6651918
TMPRSS2-ERGchr2142870044chr2139817542187HLA-B15:73KMALNSEAL0.95650.7512716
TMPRSS2-ERGchr2142870044chr2139817542187HLA-B15:30KMALNSEAL0.88740.6884716
TMPRSS2-ERGchr2142870044chr2139817542187HLA-C01:03KMALNSEAL0.66680.9567716
TMPRSS2-ERGchr2142870044chr2139817542187HLA-C01:02KMALNSEAL0.54630.9486716
TMPRSS2-ERGchr2142870044chr2139817542187HLA-A02:03ALNSEALSVV0.99930.7447919
TMPRSS2-ERGchr2142879875chr2139817542116HLA-B27:07ARQEALSVV0.99930.60531120
TMPRSS2-ERGchr2142879875chr2139817542116HLA-B27:04ARQEALSVV0.99910.70831120
TMPRSS2-ERGchr2142879875chr2139817542116HLA-B39:06ARQEALSVV0.9980.85991120
TMPRSS2-ERGchr2142879875chr2139817542116HLA-B39:06VRSAARQEA0.97230.9184716
TMPRSS2-ERGchr2142879875chr2139817542116HLA-B52:01AARQEALSV0.91930.98831019
TMPRSS2-ERGchr2142879875chr2139817542116HLA-B07:10ARQEALSVV0.04390.56461120
TMPRSS2-ERGchr2142879875chr2139817542116HLA-B07:10VRSAARQEAL0.86820.7737717
TMPRSS2-ERGchr2142879875chr2139817542116HLA-B27:14ARQEALSVV0.99920.6791120
TMPRSS2-ERGchr2142879875chr2139817542116HLA-C15:06RSAARQEAL0.99860.951817
TMPRSS2-ERGchr2142879875chr2139817542116HLA-C03:19RSAARQEAL0.99810.9935817
TMPRSS2-ERGchr2142879875chr2139817542116HLA-C15:06AARQEALSV0.99710.95241019
TMPRSS2-ERGchr2142879875chr2139817542116HLA-C12:04AARQEALSV0.99650.98221019
TMPRSS2-ERGchr2142879875chr2139817542116HLA-C06:03AARQEALSV0.99610.98641019
TMPRSS2-ERGchr2142879875chr2139817542116HLA-C03:08RSAARQEAL0.99480.9548817
TMPRSS2-ERGchr2142879875chr2139817542116HLA-B39:12ARQEALSVV0.99050.91311120
TMPRSS2-ERGchr2142879875chr2139817542116HLA-C12:12AARQEALSV0.98810.9611019
TMPRSS2-ERGchr2142879875chr2139817542116HLA-B73:01VRSAARQEA0.98710.9289716
TMPRSS2-ERGchr2142879875chr2139817542116HLA-B73:01ARQEALSVV0.98620.83441120
TMPRSS2-ERGchr2142879875chr2139817542116HLA-C02:06AARQEALSV0.97720.95811019
TMPRSS2-ERGchr2142879875chr2139817542116HLA-C12:16ARQEALSVV0.01190.94681120
TMPRSS2-ERGchr2142879875chr2139817542116HLA-C03:17SAARQEAL0.99980.9849917
TMPRSS2-ERGchr2142879875chr2139817542116HLA-C16:01SAARQEAL0.97520.9849917
TMPRSS2-ERGchr2142879875chr2139817542116HLA-B07:13SAARQEAL0.94990.8976917
TMPRSS2-ERGchr2142879875chr2139817542116HLA-B27:06ARQEALSVV0.99940.7861120
TMPRSS2-ERGchr2142879875chr2139817542116HLA-B27:09ARQEALSVV0.99920.56131120
TMPRSS2-ERGchr2142879875chr2139817542116HLA-C15:05RSAARQEAL0.99880.9615817
TMPRSS2-ERGchr2142879875chr2139817542116HLA-C15:02RSAARQEAL0.99860.9281817
TMPRSS2-ERGchr2142879875chr2139817542116HLA-C15:02AARQEALSV0.99850.94951019
TMPRSS2-ERGchr2142879875chr2139817542116HLA-C15:05AARQEALSV0.99770.95161019
TMPRSS2-ERGchr2142879875chr2139817542116HLA-C03:17RSAARQEAL0.99280.9866817
TMPRSS2-ERGchr2142879875chr2139817542116HLA-B07:13RSAARQEAL0.98590.9208817
TMPRSS2-ERGchr2142879875chr2139817542116HLA-C03:17AARQEALSV0.97530.97241019
TMPRSS2-ERGchr2142879875chr2139817542116HLA-C16:02RSAARQEAL0.97350.9942817
TMPRSS2-ERGchr2142879875chr2139817542116HLA-B07:13AARQEALSV0.96880.88471019
TMPRSS2-ERGchr2142879875chr2139817542116HLA-C12:03AARQEALSV0.95880.96721019
TMPRSS2-ERGchr2142879875chr2139817542116HLA-C07:01ARQEALSVV0.95430.82651120
TMPRSS2-ERGchr2142879875chr2139817542116HLA-C06:08ARQEALSVV0.93220.97491120
TMPRSS2-ERGchr2142879875chr2139817542116HLA-C16:01RSAARQEAL0.92970.9825817
TMPRSS2-ERGchr2142879875chr2139817542116HLA-C16:04AARQEALSV0.91420.96771019
TMPRSS2-ERGchr2142879875chr2139817542116HLA-C07:04ARQEALSVV0.76260.94681120
TMPRSS2-ERGchr2142879875chr2139817542116HLA-C16:01AARQEALSV0.72920.98411019
TMPRSS2-ERGchr2142879875chr2139817542116HLA-C07:22ARQEALSVV0.6330.8421120
TMPRSS2-ERGchr2142879875chr2139817542116HLA-C06:06ARQEALSVV0.6040.98781120
TMPRSS2-ERGchr2142879875chr2139817542116HLA-C06:02ARQEALSVV0.12910.97691120
TMPRSS2-ERGchr2142879875chr2139817542116HLA-C06:17ARQEALSVV0.12910.97691120

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Potential FusionNeoAntigen Information of TMPRSS2-ERG in HLA II

check button Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.
TMPRSS2-ERG_42860320_39817543.msa
TMPRSS2-ERG_42879875_39817542.msa

check button Potential FusionNeoAntigen Information
* We used NetMHCIIpan v4.1 (%rank<0.5).
Fusion geneHchrHbpTgeneTchrTbpHLA IIFusionNeoAntigen peptideNeoantigen start (at BP 13)Neoantigen end (at BP 13)
TMPRSS2-ERGchr2142860320chr2139817543534DRB1-1002RIGVEALSVVSEDQS924
TMPRSS2-ERGchr2142879875chr2139817542116DRB1-0804KAGVRSAARQEALSV419
TMPRSS2-ERGchr2142879875chr2139817542116DRB1-0804VKAGVRSAARQEALS318
TMPRSS2-ERGchr2142879875chr2139817542116DRB1-0820KAGVRSAARQEALSV419
TMPRSS2-ERGchr2142879875chr2139817542116DRB1-0820VKAGVRSAARQEALS318
TMPRSS2-ERGchr2142879875chr2139817542116DRB1-0831KAGVRSAARQEALSV419
TMPRSS2-ERGchr2142879875chr2139817542116DRB1-0831VKAGVRSAARQEALS318
TMPRSS2-ERGchr2142879875chr2139817542116DRB1-1103KAGVRSAARQEALSV419
TMPRSS2-ERGchr2142879875chr2139817542116DRB1-1103VKAGVRSAARQEALS318
TMPRSS2-ERGchr2142879875chr2139817542116DRB1-1104KAGVRSAARQEALSV419
TMPRSS2-ERGchr2142879875chr2139817542116DRB1-1104VKAGVRSAARQEALS318
TMPRSS2-ERGchr2142879875chr2139817542116DRB1-1106KAGVRSAARQEALSV419
TMPRSS2-ERGchr2142879875chr2139817542116DRB1-1106VKAGVRSAARQEALS318
TMPRSS2-ERGchr2142879875chr2139817542116DRB1-1113KAGVRSAARQEALSV419
TMPRSS2-ERGchr2142879875chr2139817542116DRB1-1117KAGVRSAARQEALSV419
TMPRSS2-ERGchr2142879875chr2139817542116DRB1-1117VKAGVRSAARQEALS318
TMPRSS2-ERGchr2142879875chr2139817542116DRB1-1117EVKAGVRSAARQEAL217
TMPRSS2-ERGchr2142879875chr2139817542116DRB1-1125KAGVRSAARQEALSV419
TMPRSS2-ERGchr2142879875chr2139817542116DRB1-1125VKAGVRSAARQEALS318
TMPRSS2-ERGchr2142879875chr2139817542116DRB1-1134KAGVRSAARQEALSV419
TMPRSS2-ERGchr2142879875chr2139817542116DRB1-1135KAGVRSAARQEALSV419
TMPRSS2-ERGchr2142879875chr2139817542116DRB1-1135VKAGVRSAARQEALS318
TMPRSS2-ERGchr2142879875chr2139817542116DRB1-1138KAGVRSAARQEALSV419
TMPRSS2-ERGchr2142879875chr2139817542116DRB1-1138VKAGVRSAARQEALS318
TMPRSS2-ERGchr2142879875chr2139817542116DRB1-1141KAGVRSAARQEALSV419
TMPRSS2-ERGchr2142879875chr2139817542116DRB1-1141VKAGVRSAARQEALS318
TMPRSS2-ERGchr2142879875chr2139817542116DRB1-1142KAGVRSAARQEALSV419
TMPRSS2-ERGchr2142879875chr2139817542116DRB1-1143KAGVRSAARQEALSV419
TMPRSS2-ERGchr2142879875chr2139817542116DRB1-1143VKAGVRSAARQEALS318
TMPRSS2-ERGchr2142879875chr2139817542116DRB1-1144KAGVRSAARQEALSV419
TMPRSS2-ERGchr2142879875chr2139817542116DRB1-1144VKAGVRSAARQEALS318
TMPRSS2-ERGchr2142879875chr2139817542116DRB1-1146KAGVRSAARQEALSV419
TMPRSS2-ERGchr2142879875chr2139817542116DRB1-1146VKAGVRSAARQEALS318
TMPRSS2-ERGchr2142879875chr2139817542116DRB1-1147KAGVRSAARQEALSV419
TMPRSS2-ERGchr2142879875chr2139817542116DRB1-1147VKAGVRSAARQEALS318
TMPRSS2-ERGchr2142879875chr2139817542116DRB1-1148KAGVRSAARQEALSV419
TMPRSS2-ERGchr2142879875chr2139817542116DRB1-1148VKAGVRSAARQEALS318
TMPRSS2-ERGchr2142879875chr2139817542116DRB1-1150KAGVRSAARQEALSV419
TMPRSS2-ERGchr2142879875chr2139817542116DRB1-1150VKAGVRSAARQEALS318
TMPRSS2-ERGchr2142879875chr2139817542116DRB1-1152KAGVRSAARQEALSV419
TMPRSS2-ERGchr2142879875chr2139817542116DRB1-1152VKAGVRSAARQEALS318
TMPRSS2-ERGchr2142879875chr2139817542116DRB1-1152EVKAGVRSAARQEAL217
TMPRSS2-ERGchr2142879875chr2139817542116DRB1-1154KAGVRSAARQEALSV419
TMPRSS2-ERGchr2142879875chr2139817542116DRB1-1154VKAGVRSAARQEALS318
TMPRSS2-ERGchr2142879875chr2139817542116DRB1-1155KAGVRSAARQEALSV419
TMPRSS2-ERGchr2142879875chr2139817542116DRB1-1156KAGVRSAARQEALSV419
TMPRSS2-ERGchr2142879875chr2139817542116DRB1-1156VKAGVRSAARQEALS318
TMPRSS2-ERGchr2142879875chr2139817542116DRB1-1157KAGVRSAARQEALSV419
TMPRSS2-ERGchr2142879875chr2139817542116DRB1-1157VKAGVRSAARQEALS318
TMPRSS2-ERGchr2142879875chr2139817542116DRB1-1158KAGVRSAARQEALSV419
TMPRSS2-ERGchr2142879875chr2139817542116DRB1-1158VKAGVRSAARQEALS318
TMPRSS2-ERGchr2142879875chr2139817542116DRB1-1159KAGVRSAARQEALSV419
TMPRSS2-ERGchr2142879875chr2139817542116DRB1-1159VKAGVRSAARQEALS318
TMPRSS2-ERGchr2142879875chr2139817542116DRB1-1160KAGVRSAARQEALSV419
TMPRSS2-ERGchr2142879875chr2139817542116DRB1-1160VKAGVRSAARQEALS318
TMPRSS2-ERGchr2142879875chr2139817542116DRB1-1163KAGVRSAARQEALSV419
TMPRSS2-ERGchr2142879875chr2139817542116DRB1-1163VKAGVRSAARQEALS318
TMPRSS2-ERGchr2142879875chr2139817542116DRB1-1169KAGVRSAARQEALSV419
TMPRSS2-ERGchr2142879875chr2139817542116DRB1-1176KAGVRSAARQEALSV419
TMPRSS2-ERGchr2142879875chr2139817542116DRB1-1176VKAGVRSAARQEALS318
TMPRSS2-ERGchr2142879875chr2139817542116DRB1-1177KAGVRSAARQEALSV419
TMPRSS2-ERGchr2142879875chr2139817542116DRB1-1177VKAGVRSAARQEALS318
TMPRSS2-ERGchr2142879875chr2139817542116DRB1-1178KAGVRSAARQEALSV419
TMPRSS2-ERGchr2142879875chr2139817542116DRB1-1178VKAGVRSAARQEALS318
TMPRSS2-ERGchr2142879875chr2139817542116DRB1-1183KAGVRSAARQEALSV419
TMPRSS2-ERGchr2142879875chr2139817542116DRB1-1183VKAGVRSAARQEALS318
TMPRSS2-ERGchr2142879875chr2139817542116DRB1-1184KAGVRSAARQEALSV419
TMPRSS2-ERGchr2142879875chr2139817542116DRB1-1184VKAGVRSAARQEALS318
TMPRSS2-ERGchr2142879875chr2139817542116DRB1-1185KAGVRSAARQEALSV419
TMPRSS2-ERGchr2142879875chr2139817542116DRB1-1185VKAGVRSAARQEALS318
TMPRSS2-ERGchr2142879875chr2139817542116DRB1-1188KAGVRSAARQEALSV419
TMPRSS2-ERGchr2142879875chr2139817542116DRB1-1188VKAGVRSAARQEALS318
TMPRSS2-ERGchr2142879875chr2139817542116DRB1-1189KAGVRSAARQEALSV419
TMPRSS2-ERGchr2142879875chr2139817542116DRB1-1189VKAGVRSAARQEALS318
TMPRSS2-ERGchr2142879875chr2139817542116DRB1-1189EVKAGVRSAARQEAL217
TMPRSS2-ERGchr2142879875chr2139817542116DRB1-1192KAGVRSAARQEALSV419
TMPRSS2-ERGchr2142879875chr2139817542116DRB1-1308KAGVRSAARQEALSV419
TMPRSS2-ERGchr2142879875chr2139817542116DRB1-1308VKAGVRSAARQEALS318
TMPRSS2-ERGchr2142879875chr2139817542116DRB1-1309KAGVRSAARQEALSV419
TMPRSS2-ERGchr2142879875chr2139817542116DRB1-1309VKAGVRSAARQEALS318
TMPRSS2-ERGchr2142879875chr2139817542116DRB1-1311KAGVRSAARQEALSV419
TMPRSS2-ERGchr2142879875chr2139817542116DRB1-1311VKAGVRSAARQEALS318
TMPRSS2-ERGchr2142879875chr2139817542116DRB1-1318KAGVRSAARQEALSV419
TMPRSS2-ERGchr2142879875chr2139817542116DRB1-1318VKAGVRSAARQEALS318
TMPRSS2-ERGchr2142879875chr2139817542116DRB1-1324KAGVRSAARQEALSV419
TMPRSS2-ERGchr2142879875chr2139817542116DRB1-1324VKAGVRSAARQEALS318
TMPRSS2-ERGchr2142879875chr2139817542116DRB1-1342KAGVRSAARQEALSV419
TMPRSS2-ERGchr2142879875chr2139817542116DRB1-1342VKAGVRSAARQEALS318
TMPRSS2-ERGchr2142879875chr2139817542116DRB1-1344KAGVRSAARQEALSV419
TMPRSS2-ERGchr2142879875chr2139817542116DRB1-1370KAGVRSAARQEALSV419
TMPRSS2-ERGchr2142879875chr2139817542116DRB1-1370VKAGVRSAARQEALS318
TMPRSS2-ERGchr2142879875chr2139817542116DRB1-1371KAGVRSAARQEALSV419
TMPRSS2-ERGchr2142879875chr2139817542116DRB1-1372KAGVRSAARQEALSV419
TMPRSS2-ERGchr2142879875chr2139817542116DRB1-1372VKAGVRSAARQEALS318
TMPRSS2-ERGchr2142879875chr2139817542116DRB1-1376KAGVRSAARQEALSV419
TMPRSS2-ERGchr2142879875chr2139817542116DRB1-1376VKAGVRSAARQEALS318
TMPRSS2-ERGchr2142879875chr2139817542116DRB1-1384KAGVRSAARQEALSV419
TMPRSS2-ERGchr2142879875chr2139817542116DRB1-1384VKAGVRSAARQEALS318
TMPRSS2-ERGchr2142879875chr2139817542116DRB1-1405KAGVRSAARQEALSV419
TMPRSS2-ERGchr2142879875chr2139817542116DRB1-1405VKAGVRSAARQEALS318
TMPRSS2-ERGchr2142879875chr2139817542116DRB1-1405EVKAGVRSAARQEAL217
TMPRSS2-ERGchr2142879875chr2139817542116DRB1-1406KAGVRSAARQEALSV419
TMPRSS2-ERGchr2142879875chr2139817542116DRB1-1408KAGVRSAARQEALSV419
TMPRSS2-ERGchr2142879875chr2139817542116DRB1-1408VKAGVRSAARQEALS318
TMPRSS2-ERGchr2142879875chr2139817542116DRB1-1408EVKAGVRSAARQEAL217
TMPRSS2-ERGchr2142879875chr2139817542116DRB1-1411KAGVRSAARQEALSV419
TMPRSS2-ERGchr2142879875chr2139817542116DRB1-1411VKAGVRSAARQEALS318
TMPRSS2-ERGchr2142879875chr2139817542116DRB1-1411EVKAGVRSAARQEAL217
TMPRSS2-ERGchr2142879875chr2139817542116DRB1-1412KAGVRSAARQEALSV419
TMPRSS2-ERGchr2142879875chr2139817542116DRB1-1415KAGVRSAARQEALSV419
TMPRSS2-ERGchr2142879875chr2139817542116DRB1-1415VKAGVRSAARQEALS318
TMPRSS2-ERGchr2142879875chr2139817542116DRB1-1417KAGVRSAARQEALSV419
TMPRSS2-ERGchr2142879875chr2139817542116DRB1-1418KAGVRSAARQEALSV419
TMPRSS2-ERGchr2142879875chr2139817542116DRB1-1418VKAGVRSAARQEALS318
TMPRSS2-ERGchr2142879875chr2139817542116DRB1-1420KAGVRSAARQEALSV419
TMPRSS2-ERGchr2142879875chr2139817542116DRB1-1421KAGVRSAARQEALSV419
TMPRSS2-ERGchr2142879875chr2139817542116DRB1-1421VKAGVRSAARQEALS318
TMPRSS2-ERGchr2142879875chr2139817542116DRB1-1423KAGVRSAARQEALSV419
TMPRSS2-ERGchr2142879875chr2139817542116DRB1-1423VKAGVRSAARQEALS318
TMPRSS2-ERGchr2142879875chr2139817542116DRB1-1423EVKAGVRSAARQEAL217
TMPRSS2-ERGchr2142879875chr2139817542116DRB1-1429KAGVRSAARQEALSV419
TMPRSS2-ERGchr2142879875chr2139817542116DRB1-1433KAGVRSAARQEALSV419
TMPRSS2-ERGchr2142879875chr2139817542116DRB1-1433VKAGVRSAARQEALS318
TMPRSS2-ERGchr2142879875chr2139817542116DRB1-1434KAGVRSAARQEALSV419
TMPRSS2-ERGchr2142879875chr2139817542116DRB1-1434VKAGVRSAARQEALS318
TMPRSS2-ERGchr2142879875chr2139817542116DRB1-1437KAGVRSAARQEALSV419
TMPRSS2-ERGchr2142879875chr2139817542116DRB1-1437VKAGVRSAARQEALS318
TMPRSS2-ERGchr2142879875chr2139817542116DRB1-1443KAGVRSAARQEALSV419
TMPRSS2-ERGchr2142879875chr2139817542116DRB1-1443VKAGVRSAARQEALS318
TMPRSS2-ERGchr2142879875chr2139817542116DRB1-1443EVKAGVRSAARQEAL217
TMPRSS2-ERGchr2142879875chr2139817542116DRB1-1445KAGVRSAARQEALSV419
TMPRSS2-ERGchr2142879875chr2139817542116DRB1-1445VKAGVRSAARQEALS318
TMPRSS2-ERGchr2142879875chr2139817542116DRB1-1456KAGVRSAARQEALSV419
TMPRSS2-ERGchr2142879875chr2139817542116DRB1-1456VKAGVRSAARQEALS318
TMPRSS2-ERGchr2142879875chr2139817542116DRB1-1456EVKAGVRSAARQEAL217
TMPRSS2-ERGchr2142879875chr2139817542116DRB1-1459KAGVRSAARQEALSV419
TMPRSS2-ERGchr2142879875chr2139817542116DRB1-1459VKAGVRSAARQEALS318
TMPRSS2-ERGchr2142879875chr2139817542116DRB1-1459EVKAGVRSAARQEAL217
TMPRSS2-ERGchr2142879875chr2139817542116DRB1-1464KAGVRSAARQEALSV419
TMPRSS2-ERGchr2142879875chr2139817542116DRB1-1464VKAGVRSAARQEALS318
TMPRSS2-ERGchr2142879875chr2139817542116DRB1-1472KAGVRSAARQEALSV419
TMPRSS2-ERGchr2142879875chr2139817542116DRB1-1472VKAGVRSAARQEALS318
TMPRSS2-ERGchr2142879875chr2139817542116DRB1-1475KAGVRSAARQEALSV419
TMPRSS2-ERGchr2142879875chr2139817542116DRB1-1475VKAGVRSAARQEALS318
TMPRSS2-ERGchr2142879875chr2139817542116DRB1-1480KAGVRSAARQEALSV419
TMPRSS2-ERGchr2142879875chr2139817542116DRB1-1480VKAGVRSAARQEALS318
TMPRSS2-ERGchr2142879875chr2139817542116DRB1-1481KAGVRSAARQEALSV419
TMPRSS2-ERGchr2142879875chr2139817542116DRB1-1481VKAGVRSAARQEALS318
TMPRSS2-ERGchr2142879875chr2139817542116DRB1-1483KAGVRSAARQEALSV419
TMPRSS2-ERGchr2142879875chr2139817542116DRB1-1484KAGVRSAARQEALSV419
TMPRSS2-ERGchr2142879875chr2139817542116DRB1-1484VKAGVRSAARQEALS318
TMPRSS2-ERGchr2142879875chr2139817542116DRB1-1491KAGVRSAARQEALSV419
TMPRSS2-ERGchr2142879875chr2139817542116DRB1-1491VKAGVRSAARQEALS318
TMPRSS2-ERGchr2142879875chr2139817542116DRB1-1491EVKAGVRSAARQEAL217
TMPRSS2-ERGchr2142879875chr2139817542116DRB1-1495KAGVRSAARQEALSV419
TMPRSS2-ERGchr2142879875chr2139817542116DRB1-1495VKAGVRSAARQEALS318
TMPRSS2-ERGchr2142879875chr2139817542116DRB1-1496KAGVRSAARQEALSV419
TMPRSS2-ERGchr2142879875chr2139817542116DRB1-1496VKAGVRSAARQEALS318
TMPRSS2-ERGchr2142879875chr2139817542116DRB1-1496EVKAGVRSAARQEAL217

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Fusion breakpoint peptide structures of TMPRSS2-ERG

check button3D structures of the fusion breakpoint peptide of 14AA sequence that have potential fusion neoantigens
* The minimum length of the amino acid sequence in RoseTTAFold is 14AA. Here, we predicted the 14AA fusion protein breakpoint sequence not the fusion neoantigen peptide, which is shorter than 14 AA.
File nameBPseqHgeneTgeneHchrHbpTchrTbpAAlen
3100GRTRIGVEALSVVSTMPRSS2ERGchr2142860320chr2139817543534
File nameBPseqHgeneTgeneHchrHbpTchrTbpAAlen
3221GVRSAARQEALSVVTMPRSS2ERGchr2142879875chr2139817542116
File nameBPseqHgeneTgeneHchrHbpTchrTbpAAlen
8696SKMALNSEALSVVSTMPRSS2ERGchr2142870044chr2139817542187

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Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D of TMPRSS2-ERG

check buttonVirtual screening between 25 HLAs (from PDB) and FusionNeoAntigens
* We used Glide to predict the interaction between HLAs and neoantigens.
HLA allelePDB IDFile nameBPseqDocking scoreGlide score
HLA-B14:023BVN3100GRTRIGVEALSVVS-7.9962-8.1096
HLA-B14:023BVN3100GRTRIGVEALSVVS-5.70842-6.74372
HLA-B52:013W393100GRTRIGVEALSVVS-6.83737-6.95077
HLA-B52:013W393100GRTRIGVEALSVVS-4.4836-5.5189
HLA-A11:014UQ23100GRTRIGVEALSVVS-10.0067-10.1201
HLA-A11:014UQ23100GRTRIGVEALSVVS-9.03915-10.0745
HLA-A24:025HGA3100GRTRIGVEALSVVS-6.56204-6.67544
HLA-A24:025HGA3100GRTRIGVEALSVVS-5.42271-6.45801
HLA-B44:053DX83100GRTRIGVEALSVVS-7.85648-8.89178
HLA-B44:053DX83100GRTRIGVEALSVVS-5.3978-5.5112
HLA-A02:016TDR3100GRTRIGVEALSVVS-3.37154-4.40684
HLA-B14:023BVN3221GVRSAARQEALSVV-7.15543-7.26883
HLA-B14:023BVN3221GVRSAARQEALSVV-4.77435-5.80965
HLA-B52:013W393221GVRSAARQEALSVV-6.80875-6.92215
HLA-B52:013W393221GVRSAARQEALSVV-4.20386-5.23916
HLA-A11:014UQ23221GVRSAARQEALSVV-7.5194-8.5547
HLA-A11:014UQ23221GVRSAARQEALSVV-6.9601-7.0735
HLA-A24:025HGA3221GVRSAARQEALSVV-7.52403-7.63743
HLA-A24:025HGA3221GVRSAARQEALSVV-5.82433-6.85963
HLA-B27:056PYJ3221GVRSAARQEALSVV-3.28285-4.31815
HLA-B44:053DX83221GVRSAARQEALSVV-5.91172-6.94702
HLA-B44:053DX83221GVRSAARQEALSVV-4.24346-4.35686
HLA-B14:023BVN8696SKMALNSEALSVVS-7.15543-7.26883
HLA-B14:023BVN8696SKMALNSEALSVVS-4.77435-5.80965
HLA-B52:013W398696SKMALNSEALSVVS-6.80875-6.92215
HLA-B52:013W398696SKMALNSEALSVVS-4.20386-5.23916
HLA-A11:014UQ28696SKMALNSEALSVVS-7.5194-8.5547
HLA-A11:014UQ28696SKMALNSEALSVVS-6.9601-7.0735
HLA-A24:025HGA8696SKMALNSEALSVVS-7.52403-7.63743
HLA-A24:025HGA8696SKMALNSEALSVVS-5.82433-6.85963
HLA-B27:056PYJ8696SKMALNSEALSVVS-3.28285-4.31815
HLA-B44:053DX88696SKMALNSEALSVVS-5.91172-6.94702
HLA-B44:053DX88696SKMALNSEALSVVS-4.24346-4.35686

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Vaccine Design for the FusionNeoAntigens of TMPRSS2-ERG

check button mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-Is.
Fusion geneHchrHbpTchrTbpStart in +/-13AAEnd in +/-13AAFusionNeoAntigen peptide sequenceFusionNeoAntigen RNA sequence
TMPRSS2-ERGchr2142860320chr2139817543615GRTRIGVEAGGGAGGACGAGAATCGGTGTGGAAGCC
TMPRSS2-ERGchr2142860320chr2139817543616GRTRIGVEALGGGAGGACGAGAATCGGTGTGGAAGCCTTA
TMPRSS2-ERGchr2142860320chr2139817543716RTRIGVEALAGGACGAGAATCGGTGTGGAAGCCTTA
TMPRSS2-ERGchr2142860320chr2139817543718RTRIGVEALSVAGGACGAGAATCGGTGTGGAAGCCTTATCAGTT
TMPRSS2-ERGchr2142860320chr2139817543816TRIGVEALACGAGAATCGGTGTGGAAGCCTTA
TMPRSS2-ERGchr2142860320chr2139817543817TRIGVEALSACGAGAATCGGTGTGGAAGCCTTATCA
TMPRSS2-ERGchr2142860320chr2139817543818TRIGVEALSVACGAGAATCGGTGTGGAAGCCTTATCAGTT
TMPRSS2-ERGchr2142870044chr2139817542615SKMALNSEAAGCAAGATGGCTTTGAACTCAGAAGCC
TMPRSS2-ERGchr2142870044chr2139817542716KMALNSEALAAGATGGCTTTGAACTCAGAAGCCTTA
TMPRSS2-ERGchr2142870044chr2139817542816MALNSEALATGGCTTTGAACTCAGAAGCCTTA
TMPRSS2-ERGchr2142870044chr2139817542918ALNSEALSVGCTTTGAACTCAGAAGCCTTATCAGTT
TMPRSS2-ERGchr2142870044chr2139817542919ALNSEALSVVGCTTTGAACTCAGAAGCCTTATCAGTTGTG
TMPRSS2-ERGchr2142879875chr21398175421019AARQEALSVGCGCGGCAGGAAGCCTTATCAGTTGTG
TMPRSS2-ERGchr2142879875chr21398175421120ARQEALSVVCGGCAGGAAGCCTTATCAGTTGTGAGT
TMPRSS2-ERGchr2142879875chr2139817542716VRSAARQEAAGGAGCGCGGCGCGGCAGGAAGCCTTA
TMPRSS2-ERGchr2142879875chr2139817542717VRSAARQEALAGGAGCGCGGCGCGGCAGGAAGCCTTATCA
TMPRSS2-ERGchr2142879875chr2139817542817RSAARQEALAGCGCGGCGCGGCAGGAAGCCTTATCA
TMPRSS2-ERGchr2142879875chr2139817542917SAARQEALGCGGCGCGGCAGGAAGCCTTATCA

check button mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-IIs.
Fusion geneHchrHbpTchrTbpStart in +/-13AAEnd in +/-13AAFusionNeoAntigen peptideFusionNEoAntigen RNA sequence
TMPRSS2-ERGchr2142860320chr2139817543924RIGVEALSVVSEDQSAGAATCGGTGTGGAAGCCTTATCAGTTGTGAGTGAGGACCAGTCG
TMPRSS2-ERGchr2142879875chr2139817542217EVKAGVRSAARQEALGTGAAAGCGGGTGTGAGGAGCGCGGCGCGGCAGGAAGCCTTATCA
TMPRSS2-ERGchr2142879875chr2139817542318VKAGVRSAARQEALSAAAGCGGGTGTGAGGAGCGCGGCGCGGCAGGAAGCCTTATCAGTT
TMPRSS2-ERGchr2142879875chr2139817542419KAGVRSAARQEALSVGCGGGTGTGAGGAGCGCGGCGCGGCAGGAAGCCTTATCAGTTGTG

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Information of the samples that have these potential fusion neoantigens of TMPRSS2-ERG

check button These samples were reported as having these fusion breakpoints. For individual breakpoints, we checked the open reading frames considering multiple gene isoforms and chose the in-frame fusion genes only. Then, we made fusion protein sequences and predicted the fusion neoantigens. These fusion-positive samples may have these potential fusion neoantigens.
Cancer typeFusion geneHchrHbpHenstTchrTbpTenstSample
PRADTMPRSS2-ERGchr2142879875ENST00000398585chr2139817542ENST00000288319TCGA-MG-AAMC-01A
PRADTMPRSS2-ERGchr2142870044ENST00000398585chr2139817542ENST00000288319TCGA-QU-A6IN-01A
PRADTMPRSS2-ERGchr2142860320ENST00000458356chr2139817543ENST00000288319TCGA-KK-A6DY-01A

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Potential target of CAR-T therapy development for TMPRSS2-ERG

check button Predicted 3D structure. We used RoseTTAFold.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, to provide the retention of the transmembrane domain, we only show the protein feature retention information of those transmembrane features


* Minus value of BPloci means that the break point is located before the CDS.
- In-frame and retained 'Transmembrane'.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTMPRSS2chr21:42860320chr21:39817543ENST00000332149-51485_105148493.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneTMPRSS2chr21:42860320chr21:39817543ENST00000398585-51485_105185530.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneTMPRSS2chr21:42860320chr21:39817543ENST00000458356-51485_105148493.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneTMPRSS2chr21:42860321chr21:39817544ENST00000332149-51485_105148493.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneTMPRSS2chr21:42860321chr21:39817544ENST00000398585-51485_105185530.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneTMPRSS2chr21:42860321chr21:39817544ENST00000458356-51485_105148493.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneTMPRSS2chr21:42866282chr21:39817543ENST00000398585-31485_105116530.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneTMPRSS2chr21:42866283chr21:39817544ENST00000398585-31485_105116530.0TransmembraneHelical%3B Signal-anchor for type II membrane protein

check button Subcellular localization prediction of the transmembrane domain retained fusion proteins
* We used DeepLoc 1.0. The order of the X-axis of the barplot is as follows: Entry_ID, Localization, Type, Nucleus, Cytoplasm, Extracellular, Mitochondrion, Cell_membrane, Endoplasmic_reticulum, Plastid, Golgi.apparatus, Lysosome.Vacuole, Peroxisome. Y-axis is the output score of DeepLoc. Clicking the image will open a new tab with a large image.
HgeneHchrHbpHenstTgeneTchrTbpTenstDeepLoc result

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Related Drugs to TMPRSS2-ERG

check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID
TMPRSS2ERGLiposomal Nanovectors Enhances Docetaxel TreatmenPubMed31614005

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Related Diseases to TMPRSS2-ERG

check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID
TMPRSS2ERGProstate CancerPubMed31614005
TMPRSS2ERGProstate AdenocarcinomaMyCancerGenome
TMPRSS2ERGProstate Neuroendocrine NeoplasmMyCancerGenome
TMPRSS2ERGProstate Small Cell CarcinomaMyCancerGenome
TMPRSS2ERGBladder Urothelial CarcinomaMyCancerGenome
TMPRSS2ERGNeuroendocrine CarcinomaMyCancerGenome

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTMPRSS2C0033578Prostatic Neoplasms4CTD_human
HgeneTMPRSS2C0376358Malignant neoplasm of prostate4CTD_human
TgeneERGC0033578Prostatic Neoplasms7CTD_human
TgeneERGC0376358Malignant neoplasm of prostate7CTD_human
TgeneERGC0023418leukemia1CTD_human
TgeneERGC0023452Childhood Acute Lymphoblastic Leukemia1CTD_human
TgeneERGC0023453L2 Acute Lymphoblastic Leukemia1CTD_human
TgeneERGC0023467Leukemia, Myelocytic, Acute1CTD_human
TgeneERGC0026998Acute Myeloid Leukemia, M11CTD_human
TgeneERGC0279980Extra-osseous Ewing's sarcoma1ORPHANET
TgeneERGC1879321Acute Myeloid Leukemia (AML-M2)1CTD_human
TgeneERGC1961102Precursor Cell Lymphoblastic Leukemia Lymphoma1CTD_human