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level3

	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Potential Active Site Information
	Potentially Interacting Small Molecules through Virtual Screening
	Biochemical Features of Small Molecules with ADME
	Drug Toxicity Information
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:YWHAE-NUTM2B

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: YWHAE-NUTM2B
	FusionPDB ID: 100148
	FusionGDB2.0 ID: 100148
		Hgene	Tgene
	Gene symbol	YWHAE	NUTM2B
	Gene ID	7531	729262
	Gene name	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon	NUT family member 2B
	Synonyms	14-3-3E\|HEL2\|KCIP-1\|MDCR\|MDS	FAM22B\|bA119F19.1
	Cytomap	17p13.3	10q22.3
	Type of gene	protein-coding	protein-coding
	Description	14-3-3 protein epsilon14-3-3 epsilonepididymis luminal protein 2mitochondrial import stimulation factor L subunitprotein kinase C inhibitor protein-1tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptidetyrosine	NUT family member 2Bfamily with sequence similarity 22, member Bprotein FAM22B
	Modification date	20200327	20200313
	UniProtAcc	P62258	A6NNL0
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000571732, ENST00000264335, ENST00000498643, ENST00000573026, ENST00000575977,	ENST00000372321, ENST00000429828, ENST00000448135,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	28 X 9 X 15=3780	1 X 3 X 2=6
	# samples	42	2
	** MAII score	log2(42/3780*10)=-3.16992500144231 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(2/6*10)=1.73696559416621
Context (manual curation of fusion genes in FusionPDB)	PubMed: YWHAE [Title/Abstract] AND NUTM2B [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	YWHAE(1257505)-NUTM2B(81465797), # samples:1
Anticipated loss of major functional domain due to fusion event.	YWHAE-NUTM2B seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. YWHAE-NUTM2B seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. YWHAE-NUTM2B seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor by not retaining the major functional domain in the partially deleted in-frame ORF. YWHAE-NUTM2B seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. YWHAE-NUTM2B seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF. YWHAE-NUTM2B seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF. YWHAE-NUTM2B seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	YWHAE	GO:0000165	MAPK cascade	12917326
Hgene	YWHAE	GO:0034605	cellular response to heat	12917326
Hgene	YWHAE	GO:0046827	positive regulation of protein export from nucleus	12917326
Hgene	YWHAE	GO:0051480	regulation of cytosolic calcium ion concentration	18029012
Hgene	YWHAE	GO:0060306	regulation of membrane repolarization	11953308
Hgene	YWHAE	GO:1901016	regulation of potassium ion transmembrane transporter activity	11953308
Hgene	YWHAE	GO:1901020	negative regulation of calcium ion transmembrane transporter activity	18029012
Hgene	YWHAE	GO:1902309	negative regulation of peptidyl-serine dephosphorylation	11953308
Hgene	YWHAE	GO:1905913	negative regulation of calcium ion export across plasma membrane	18029012

Fusion gene breakpoints across YWHAE (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across NUTM2B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerKB3	.	.	YWHAE	chr17	1257504	-	NUTM2B	chr10	81465798
ChimerKB3	.	.	YWHAE	chr17	1257504	-	NUTM2B	chr10	81465832
ChiTaRS5.0	N/A	JN999699	YWHAE	chr17	1257505	-	NUTM2B	chr10	81465797	+

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000264335	YWHAE	chr17	1257504	-	ENST00000429828	NUTM2B	chr10	81465798		3504	983	202	3237	1011
ENST00000264335	YWHAE	chr17	1257504	-	ENST00000448135	NUTM2B	chr10	81465798		2491	983	202	2490	763
ENST00000264335	YWHAE	chr17	1257504	-	ENST00000372321	NUTM2B	chr10	81465798		4240	983	202	2490	762
ENST00000264335	YWHAE	chr17	1257504	-	ENST00000429828	NUTM2B	chr10	81465832		3469	983	995	3202	735
ENST00000264335	YWHAE	chr17	1257504	-	ENST00000448135	NUTM2B	chr10	81465832		2456	983	995	2455	487
ENST00000264335	YWHAE	chr17	1257504	-	ENST00000372321	NUTM2B	chr10	81465832		4205	983	995	2455	486
ENST00000264335	YWHAE	chr17	1257505	-	ENST00000429828	NUTM2B	chr10	81465797	+	3504	983	202	3237	1011
ENST00000264335	YWHAE	chr17	1257505	-	ENST00000448135	NUTM2B	chr10	81465797	+	2491	983	202	2490	763
ENST00000264335	YWHAE	chr17	1257505	-	ENST00000372321	NUTM2B	chr10	81465797	+	4240	983	202	2490	762

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000264335	ENST00000429828	YWHAE	chr17	1257505	-	NUTM2B	chr10	81465797	+	0.00224913	0.9977508
ENST00000264335	ENST00000448135	YWHAE	chr17	1257505	-	NUTM2B	chr10	81465797	+	0.012580304	0.98741966
ENST00000264335	ENST00000372321	YWHAE	chr17	1257505	-	NUTM2B	chr10	81465797	+	0.004356688	0.9956434

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>100148_100148_1_YWHAE-NUTM2B_YWHAE_chr17_1257504_ENST00000264335_NUTM2B_chr10_81465798_ENST00000372321_length(amino acids)=762AA_BP=260
MRESETLSASIRRADPAGAAAAMDDREDLVYQAKLAEQAERYDEMVESMKKVAGMDVELTVEERNLLSVAYKNVIGARRASWRIISSIEQ
KEENKGGEDKLKMIREYRQMVETELKLICCDILDVLDKHLIPAANTGESKVFYYKMKGDYHRYLAEFATGNDRKEAAENSLVAYKAASDI
AMTELPPTHPIRLGLALNFSVFYYEILNSPDRACRLAKAAFDDAIAELDTLSEESYKDSTLIMQLLRDNLTLWTSDMQGDAYPVLGPGVT
ANPGTSLSVFTALPFTTPAPGPAHGPLLVTAGAPPGGPLVLSTFPSTPLVTEQDGCGPSGAGASNVFVQMRTEVGPVKAAQAQTLVLTQA
PLVWQAPGALCGGVVCPPPLLLAAAPVVPVMAAQVVGGTQACEGGWSQGLPLPPPPPPAAQLPPIVSQGNAGPWPQGAHGESSLASSQAK
APPDDSCNPRSVYENFRLWQHYKPLARRHLPQSPDTEALSCFLIPVLRSLARRKPTMTLEEGLWRAMREWQHTSNFDRMIFYEMAEKFLE
FEAEEEMQIQKSQWMKGPQCLPPPATPRLEPRGPPAPEVVKQPVYLPSKAGPKAPTACLPPPRPQRPVTKARRPPPRPHRRAETKARLPP
PRPQRPAETKVPEEIPPEVVQEYVDIMEELLGPSLGATGEPEKQREEGKVKQPQEEDWTPPDPGLLSYIDKLCSQKDFVTKVEAVIHPQF

--------------------------------------------------------------

>100148_100148_2_YWHAE-NUTM2B_YWHAE_chr17_1257504_ENST00000264335_NUTM2B_chr10_81465798_ENST00000429828_length(amino acids)=1011AA_BP=260
MRESETLSASIRRADPAGAAAAMDDREDLVYQAKLAEQAERYDEMVESMKKVAGMDVELTVEERNLLSVAYKNVIGARRASWRIISSIEQ
KEENKGGEDKLKMIREYRQMVETELKLICCDILDVLDKHLIPAANTGESKVFYYKMKGDYHRYLAEFATGNDRKEAAENSLVAYKAASDI
AMTELPPTHPIRLGLALNFSVFYYEILNSPDRACRLAKAAFDDAIAELDTLSEESYKDSTLIMQLLRDNLTLWTSDMQGDAYPVLGPGVT
ANPGTSLSVFTALPFTTPAPGPAHGPLLVTAGAPPGGPLVLSTFPSTPLVTEQDGCGPSGAGASNVFVQMRTEVGPVKAAQAQTLVLTQA
PLVWQAPGALCGGVVCPPPLLLAAAPVVPVMAAQVVGGTQACEGGWSQGLPLPPPPPPAAQLPPIVSQGNAGPWPQGAHGESSLASSQAK
APPDDSCNPRSVYENFRLWQHYKPLARRHLPQSPDTEALSCFLIPVLRSLARRKPTMTLEEGLWRAMREWQHTSNFDRMIFYEMAEKFLE
FEAEEEMQIQKSQWMKGPQCLPPPATPRLEPRGPPAPEVVKQPVYLPSKAGPKAPTACLPPPRPQRPVTKARRPPPRPHRRAETKARLPP
PRPQRPAETKVPEEIPPEVVQEYVDIMEELLGPSLGATGEPEKQREEGKVKQPQEEDWTPPDPGLLSYIDKLCSQKDFVTKVEAVIHPQF
LEELLSPDPQMDFLALSQDLEQEEGLTLAQLVEKRLPPLKEKQHARAAPSRGTARLDSSSSKFAAGQGAERDVPDPQQGVGMETCPPQMT
ARDSQGRGRAHTGMARSEDSVVLLGCQDSPGLRAAWPTSPPQDHRPTCPGVGTKDALDLPGGSPVRESHGLAQGSSEEEELPSLAFLLGS
QHKLLPWWLPQSPVPASGLLSPEKWGPQGTHQSPSAERRGLNLAPSPANKAKKRPLFGSLSPAEKTPYPGPGLRVSGEQSLTWGLGGPSQ

--------------------------------------------------------------

>100148_100148_3_YWHAE-NUTM2B_YWHAE_chr17_1257504_ENST00000264335_NUTM2B_chr10_81465798_ENST00000448135_length(amino acids)=763AA_BP=260
MRESETLSASIRRADPAGAAAAMDDREDLVYQAKLAEQAERYDEMVESMKKVAGMDVELTVEERNLLSVAYKNVIGARRASWRIISSIEQ
KEENKGGEDKLKMIREYRQMVETELKLICCDILDVLDKHLIPAANTGESKVFYYKMKGDYHRYLAEFATGNDRKEAAENSLVAYKAASDI
AMTELPPTHPIRLGLALNFSVFYYEILNSPDRACRLAKAAFDDAIAELDTLSEESYKDSTLIMQLLRDNLTLWTSDMQGDAYPVLGPGVT
ANPGTSLSVFTALPFTTPAPGPAHGPLLVTAGAPPGGPLVLSTFPSTPLVTEQDGCGPSGAGASNVFVQMRTEVGPVKAAQAQTLVLTQA
PLVWQAPGALCGGVVCPPPLLLAAAPVVPVMAAQVVGGTQACEGGWSQGLPLPPPPPPAAQLPPIVSQGNAGPWPQGAHGESSLASSQAK
APPDDSCNPRSVYENFRLWQHYKPLARRHLPQSPDTEALSCFLIPVLRSLARRKPTMTLEEGLWRAMREWQHTSNFDRMIFYEMAEKFLE
FEAEEEMQIQKSQWMKGPQCLPPPATPRLEPRGPPAPEVVKQPVYLPSKAGPKAPTACLPPPRPQRPVTKARRPPPRPHRRAETKARLPP
PRPQRPAETKVPEEIPPEVVQEYVDIMEELLGPSLGATGEPEKQREEGKVKQPQEEDWTPPDPGLLSYIDKLCSQKDFVTKVEAVIHPQF

--------------------------------------------------------------

>100148_100148_4_YWHAE-NUTM2B_YWHAE_chr17_1257504_ENST00000264335_NUTM2B_chr10_81465832_ENST00000372321_length(amino acids)=486AA_BP=
MSVFTALPFTTPAPGPAHGPLLVTAGAPPGGPLVLSTFPSTPLVTEQDGCGPSGAGASNVFVQMRTEVGPVKAAQAQTLVLTQAPLVWQA
PGALCGGVVCPPPLLLAAAPVVPVMAAQVVGGTQACEGGWSQGLPLPPPPPPAAQLPPIVSQGNAGPWPQGAHGESSLASSQAKAPPDDS
CNPRSVYENFRLWQHYKPLARRHLPQSPDTEALSCFLIPVLRSLARRKPTMTLEEGLWRAMREWQHTSNFDRMIFYEMAEKFLEFEAEEE
MQIQKSQWMKGPQCLPPPATPRLEPRGPPAPEVVKQPVYLPSKAGPKAPTACLPPPRPQRPVTKARRPPPRPHRRAETKARLPPPRPQRP
AETKVPEEIPPEVVQEYVDIMEELLGPSLGATGEPEKQREEGKVKQPQEEDWTPPDPGLLSYIDKLCSQKDFVTKVEAVIHPQFLEELLS

--------------------------------------------------------------

>100148_100148_5_YWHAE-NUTM2B_YWHAE_chr17_1257504_ENST00000264335_NUTM2B_chr10_81465832_ENST00000429828_length(amino acids)=735AA_BP=
MSVFTALPFTTPAPGPAHGPLLVTAGAPPGGPLVLSTFPSTPLVTEQDGCGPSGAGASNVFVQMRTEVGPVKAAQAQTLVLTQAPLVWQA
PGALCGGVVCPPPLLLAAAPVVPVMAAQVVGGTQACEGGWSQGLPLPPPPPPAAQLPPIVSQGNAGPWPQGAHGESSLASSQAKAPPDDS
CNPRSVYENFRLWQHYKPLARRHLPQSPDTEALSCFLIPVLRSLARRKPTMTLEEGLWRAMREWQHTSNFDRMIFYEMAEKFLEFEAEEE
MQIQKSQWMKGPQCLPPPATPRLEPRGPPAPEVVKQPVYLPSKAGPKAPTACLPPPRPQRPVTKARRPPPRPHRRAETKARLPPPRPQRP
AETKVPEEIPPEVVQEYVDIMEELLGPSLGATGEPEKQREEGKVKQPQEEDWTPPDPGLLSYIDKLCSQKDFVTKVEAVIHPQFLEELLS
PDPQMDFLALSQDLEQEEGLTLAQLVEKRLPPLKEKQHARAAPSRGTARLDSSSSKFAAGQGAERDVPDPQQGVGMETCPPQMTARDSQG
RGRAHTGMARSEDSVVLLGCQDSPGLRAAWPTSPPQDHRPTCPGVGTKDALDLPGGSPVRESHGLAQGSSEEEELPSLAFLLGSQHKLLP
WWLPQSPVPASGLLSPEKWGPQGTHQSPSAERRGLNLAPSPANKAKKRPLFGSLSPAEKTPYPGPGLRVSGEQSLTWGLGGPSQSQKRKG

--------------------------------------------------------------

>100148_100148_6_YWHAE-NUTM2B_YWHAE_chr17_1257504_ENST00000264335_NUTM2B_chr10_81465832_ENST00000448135_length(amino acids)=487AA_BP=
MSVFTALPFTTPAPGPAHGPLLVTAGAPPGGPLVLSTFPSTPLVTEQDGCGPSGAGASNVFVQMRTEVGPVKAAQAQTLVLTQAPLVWQA
PGALCGGVVCPPPLLLAAAPVVPVMAAQVVGGTQACEGGWSQGLPLPPPPPPAAQLPPIVSQGNAGPWPQGAHGESSLASSQAKAPPDDS
CNPRSVYENFRLWQHYKPLARRHLPQSPDTEALSCFLIPVLRSLARRKPTMTLEEGLWRAMREWQHTSNFDRMIFYEMAEKFLEFEAEEE
MQIQKSQWMKGPQCLPPPATPRLEPRGPPAPEVVKQPVYLPSKAGPKAPTACLPPPRPQRPVTKARRPPPRPHRRAETKARLPPPRPQRP
AETKVPEEIPPEVVQEYVDIMEELLGPSLGATGEPEKQREEGKVKQPQEEDWTPPDPGLLSYIDKLCSQKDFVTKVEAVIHPQFLEELLS

--------------------------------------------------------------

>100148_100148_7_YWHAE-NUTM2B_YWHAE_chr17_1257505_ENST00000264335_NUTM2B_chr10_81465797_ENST00000372321_length(amino acids)=762AA_BP=260
MRESETLSASIRRADPAGAAAAMDDREDLVYQAKLAEQAERYDEMVESMKKVAGMDVELTVEERNLLSVAYKNVIGARRASWRIISSIEQ
KEENKGGEDKLKMIREYRQMVETELKLICCDILDVLDKHLIPAANTGESKVFYYKMKGDYHRYLAEFATGNDRKEAAENSLVAYKAASDI
AMTELPPTHPIRLGLALNFSVFYYEILNSPDRACRLAKAAFDDAIAELDTLSEESYKDSTLIMQLLRDNLTLWTSDMQGDAYPVLGPGVT
ANPGTSLSVFTALPFTTPAPGPAHGPLLVTAGAPPGGPLVLSTFPSTPLVTEQDGCGPSGAGASNVFVQMRTEVGPVKAAQAQTLVLTQA
PLVWQAPGALCGGVVCPPPLLLAAAPVVPVMAAQVVGGTQACEGGWSQGLPLPPPPPPAAQLPPIVSQGNAGPWPQGAHGESSLASSQAK
APPDDSCNPRSVYENFRLWQHYKPLARRHLPQSPDTEALSCFLIPVLRSLARRKPTMTLEEGLWRAMREWQHTSNFDRMIFYEMAEKFLE
FEAEEEMQIQKSQWMKGPQCLPPPATPRLEPRGPPAPEVVKQPVYLPSKAGPKAPTACLPPPRPQRPVTKARRPPPRPHRRAETKARLPP
PRPQRPAETKVPEEIPPEVVQEYVDIMEELLGPSLGATGEPEKQREEGKVKQPQEEDWTPPDPGLLSYIDKLCSQKDFVTKVEAVIHPQF

--------------------------------------------------------------

>100148_100148_8_YWHAE-NUTM2B_YWHAE_chr17_1257505_ENST00000264335_NUTM2B_chr10_81465797_ENST00000429828_length(amino acids)=1011AA_BP=260
MRESETLSASIRRADPAGAAAAMDDREDLVYQAKLAEQAERYDEMVESMKKVAGMDVELTVEERNLLSVAYKNVIGARRASWRIISSIEQ
KEENKGGEDKLKMIREYRQMVETELKLICCDILDVLDKHLIPAANTGESKVFYYKMKGDYHRYLAEFATGNDRKEAAENSLVAYKAASDI
AMTELPPTHPIRLGLALNFSVFYYEILNSPDRACRLAKAAFDDAIAELDTLSEESYKDSTLIMQLLRDNLTLWTSDMQGDAYPVLGPGVT
ANPGTSLSVFTALPFTTPAPGPAHGPLLVTAGAPPGGPLVLSTFPSTPLVTEQDGCGPSGAGASNVFVQMRTEVGPVKAAQAQTLVLTQA
PLVWQAPGALCGGVVCPPPLLLAAAPVVPVMAAQVVGGTQACEGGWSQGLPLPPPPPPAAQLPPIVSQGNAGPWPQGAHGESSLASSQAK
APPDDSCNPRSVYENFRLWQHYKPLARRHLPQSPDTEALSCFLIPVLRSLARRKPTMTLEEGLWRAMREWQHTSNFDRMIFYEMAEKFLE
FEAEEEMQIQKSQWMKGPQCLPPPATPRLEPRGPPAPEVVKQPVYLPSKAGPKAPTACLPPPRPQRPVTKARRPPPRPHRRAETKARLPP
PRPQRPAETKVPEEIPPEVVQEYVDIMEELLGPSLGATGEPEKQREEGKVKQPQEEDWTPPDPGLLSYIDKLCSQKDFVTKVEAVIHPQF
LEELLSPDPQMDFLALSQDLEQEEGLTLAQLVEKRLPPLKEKQHARAAPSRGTARLDSSSSKFAAGQGAERDVPDPQQGVGMETCPPQMT
ARDSQGRGRAHTGMARSEDSVVLLGCQDSPGLRAAWPTSPPQDHRPTCPGVGTKDALDLPGGSPVRESHGLAQGSSEEEELPSLAFLLGS
QHKLLPWWLPQSPVPASGLLSPEKWGPQGTHQSPSAERRGLNLAPSPANKAKKRPLFGSLSPAEKTPYPGPGLRVSGEQSLTWGLGGPSQ

--------------------------------------------------------------

>100148_100148_9_YWHAE-NUTM2B_YWHAE_chr17_1257505_ENST00000264335_NUTM2B_chr10_81465797_ENST00000448135_length(amino acids)=763AA_BP=260
MRESETLSASIRRADPAGAAAAMDDREDLVYQAKLAEQAERYDEMVESMKKVAGMDVELTVEERNLLSVAYKNVIGARRASWRIISSIEQ
KEENKGGEDKLKMIREYRQMVETELKLICCDILDVLDKHLIPAANTGESKVFYYKMKGDYHRYLAEFATGNDRKEAAENSLVAYKAASDI
AMTELPPTHPIRLGLALNFSVFYYEILNSPDRACRLAKAAFDDAIAELDTLSEESYKDSTLIMQLLRDNLTLWTSDMQGDAYPVLGPGVT
ANPGTSLSVFTALPFTTPAPGPAHGPLLVTAGAPPGGPLVLSTFPSTPLVTEQDGCGPSGAGASNVFVQMRTEVGPVKAAQAQTLVLTQA
PLVWQAPGALCGGVVCPPPLLLAAAPVVPVMAAQVVGGTQACEGGWSQGLPLPPPPPPAAQLPPIVSQGNAGPWPQGAHGESSLASSQAK
APPDDSCNPRSVYENFRLWQHYKPLARRHLPQSPDTEALSCFLIPVLRSLARRKPTMTLEEGLWRAMREWQHTSNFDRMIFYEMAEKFLE
FEAEEEMQIQKSQWMKGPQCLPPPATPRLEPRGPPAPEVVKQPVYLPSKAGPKAPTACLPPPRPQRPVTKARRPPPRPHRRAETKARLPP
PRPQRPAETKVPEEIPPEVVQEYVDIMEELLGPSLGATGEPEKQREEGKVKQPQEEDWTPPDPGLLSYIDKLCSQKDFVTKVEAVIHPQF

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:1257505/chr10:81465797)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
YWHAE P62258	NUTM2B A6NNL0
FUNCTION: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner (By similarity). Positively regulates phosphorylated protein HSF1 nuclear export to the cytoplasm (PubMed:12917326). {ECO:0000250\|UniProtKB:P62261, ECO:0000269\|PubMed:12917326}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

NUTM2B

chr17:1257504

chr10:81465798

ENST00000429828

276_290

127.33333333333333

879.0

Compositional bias

Pro residues

Tgene

NUTM2B

chr17:1257504

chr10:81465798

ENST00000429828

307_321

127.33333333333333

879.0

Compositional bias

Polar residues

Tgene

NUTM2B

chr17:1257504

chr10:81465798

ENST00000429828

427_448

127.33333333333333

879.0

Compositional bias

Pro residues

Tgene

NUTM2B

chr17:1257504

chr10:81465798

ENST00000429828

461_476

127.33333333333333

879.0

Compositional bias

Pro residues

Tgene

NUTM2B

chr17:1257504

chr10:81465798

ENST00000429828

537_553

127.33333333333333

879.0

Compositional bias

Basic and acidic residues

Tgene

NUTM2B

chr17:1257504

chr10:81465798

ENST00000429828

863_878

127.33333333333333

879.0

Compositional bias

Basic and acidic residues

Tgene

NUTM2B

chr17:1257504

chr10:81465798

ENST00000448135

276_290

127.33333333333333

630.0

Compositional bias

Pro residues

Tgene

NUTM2B

chr17:1257504

chr10:81465798

ENST00000448135

307_321

127.33333333333333

630.0

Compositional bias

Polar residues

Tgene

NUTM2B

chr17:1257504

chr10:81465798

ENST00000448135

427_448

127.33333333333333

630.0

Compositional bias

Pro residues

Tgene

NUTM2B

chr17:1257504

chr10:81465798

ENST00000448135

461_476

127.33333333333333

630.0

Compositional bias

Pro residues

Tgene

NUTM2B

chr17:1257504

chr10:81465798

ENST00000448135

537_553

127.33333333333333

630.0

Compositional bias

Basic and acidic residues

Tgene

NUTM2B

chr17:1257504

chr10:81465798

ENST00000448135

863_878

127.33333333333333

630.0

Compositional bias

Basic and acidic residues

Tgene

NUTM2B

chr17:1257504

chr10:81465832

ENST00000429828

276_290

879.0

Compositional bias

Pro residues

Tgene

NUTM2B

chr17:1257504

chr10:81465832

ENST00000429828

307_321

879.0

Compositional bias

Polar residues

Tgene

NUTM2B

chr17:1257504

chr10:81465832

ENST00000429828

427_448

879.0

Compositional bias

Pro residues

Tgene

NUTM2B

chr17:1257504

chr10:81465832

ENST00000429828

461_476

879.0

Compositional bias

Pro residues

Tgene

NUTM2B

chr17:1257504

chr10:81465832

ENST00000429828

537_553

879.0

Compositional bias

Basic and acidic residues

Tgene

NUTM2B

chr17:1257504

chr10:81465832

ENST00000429828

863_878

879.0

Compositional bias

Basic and acidic residues

Tgene

NUTM2B

chr17:1257504

chr10:81465832

ENST00000448135

276_290

630.0

Compositional bias

Pro residues

Tgene

NUTM2B

chr17:1257504

chr10:81465832

ENST00000448135

307_321

630.0

Compositional bias

Polar residues

Tgene

NUTM2B

chr17:1257504

chr10:81465832

ENST00000448135

427_448

630.0

Compositional bias

Pro residues

Tgene

NUTM2B

chr17:1257504

chr10:81465832

ENST00000448135

461_476

630.0

Compositional bias

Pro residues

Tgene

NUTM2B

chr17:1257504

chr10:81465832

ENST00000448135

537_553

630.0

Compositional bias

Basic and acidic residues

Tgene

NUTM2B

chr17:1257504

chr10:81465832

ENST00000448135

863_878

630.0

Compositional bias

Basic and acidic residues

Tgene

NUTM2B

chr17:1257505

chr10:81465797

ENST00000429828

278_285

127.33333333333333

879.0

Compositional bias

Note=Poly-Pro

Tgene

NUTM2B

chr17:1257505

chr10:81465797

ENST00000429828

425_514

127.33333333333333

879.0

Compositional bias

Note=Pro-rich

Tgene

NUTM2B

chr17:1257505

chr10:81465797

ENST00000448135

278_285

127.33333333333333

630.0

Compositional bias

Note=Poly-Pro

Tgene

NUTM2B

chr17:1257505

chr10:81465797

ENST00000448135

425_514

127.33333333333333

630.0

Compositional bias

Note=Pro-rich

Tgene

NUTM2B

chr17:1257504

chr10:81465798

ENST00000429828

273_324

127.33333333333333

879.0

Region

Disordered

Tgene

NUTM2B

chr17:1257504

chr10:81465798

ENST00000429828

417_512

127.33333333333333

879.0

Region

Disordered

Tgene

NUTM2B

chr17:1257504

chr10:81465798

ENST00000429828

527_560

127.33333333333333

879.0

Region

Disordered

Tgene

NUTM2B

chr17:1257504

chr10:81465798

ENST00000429828

624_693

127.33333333333333

879.0

Region

Disordered

Tgene

NUTM2B

chr17:1257504

chr10:81465798

ENST00000429828

709_757

127.33333333333333

879.0

Region

Disordered

Tgene

NUTM2B

chr17:1257504

chr10:81465798

ENST00000429828

775_878

127.33333333333333

879.0

Region

Disordered

Tgene

NUTM2B

chr17:1257504

chr10:81465798

ENST00000448135

273_324

127.33333333333333

630.0

Region

Disordered

Tgene

NUTM2B

chr17:1257504

chr10:81465798

ENST00000448135

417_512

127.33333333333333

630.0

Region

Disordered

Tgene

NUTM2B

chr17:1257504

chr10:81465798

ENST00000448135

527_560

127.33333333333333

630.0

Region

Disordered

Tgene

NUTM2B

chr17:1257504

chr10:81465798

ENST00000448135

624_693

127.33333333333333

630.0

Region

Disordered

Tgene

NUTM2B

chr17:1257504

chr10:81465798

ENST00000448135

709_757

127.33333333333333

630.0

Region

Disordered

Tgene

NUTM2B

chr17:1257504

chr10:81465798

ENST00000448135

775_878

127.33333333333333

630.0

Region

Disordered

Tgene

NUTM2B

chr17:1257504

chr10:81465832

ENST00000429828

273_324

879.0

Region

Disordered

Tgene

NUTM2B

chr17:1257504

chr10:81465832

ENST00000429828

417_512

879.0

Region

Disordered

Tgene

NUTM2B

chr17:1257504

chr10:81465832

ENST00000429828

527_560

879.0

Region

Disordered

Tgene

NUTM2B

chr17:1257504

chr10:81465832

ENST00000429828

624_693

879.0

Region

Disordered

Tgene

NUTM2B

chr17:1257504

chr10:81465832

ENST00000429828

709_757

879.0

Region

Disordered

Tgene

NUTM2B

chr17:1257504

chr10:81465832

ENST00000429828

775_878

879.0

Region

Disordered

Tgene

NUTM2B

chr17:1257504

chr10:81465832

ENST00000448135

273_324

630.0

Region

Disordered

Tgene

NUTM2B

chr17:1257504

chr10:81465832

ENST00000448135

417_512

630.0

Region

Disordered

Tgene

NUTM2B

chr17:1257504

chr10:81465832

ENST00000448135

527_560

630.0

Region

Disordered

Tgene

NUTM2B

chr17:1257504

chr10:81465832

ENST00000448135

624_693

630.0

Region

Disordered

Tgene

NUTM2B

chr17:1257504

chr10:81465832

ENST00000448135

709_757

630.0

Region

Disordered

Tgene

NUTM2B

chr17:1257504

chr10:81465832

ENST00000448135

775_878

630.0

Region

Disordered

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

YWHAE

chr17:1257504

chr10:81465798

ENST00000264335

238_255

238.33333333333334

256.0

Compositional bias

Basic and acidic residues

Hgene

YWHAE

chr17:1257504

chr10:81465798

ENST00000571732

238_255

216.33333333333334

234.0

Compositional bias

Basic and acidic residues

Hgene

YWHAE

chr17:1257504

chr10:81465832

ENST00000264335

238_255

238.33333333333334

256.0

Compositional bias

Basic and acidic residues

Hgene

YWHAE

chr17:1257504

chr10:81465832

ENST00000571732

238_255

216.33333333333334

234.0

Compositional bias

Basic and acidic residues

Hgene

YWHAE

chr17:1257504

chr10:81465798

ENST00000264335

234_255

238.33333333333334

256.0

Region

Disordered

Hgene

YWHAE

chr17:1257504

chr10:81465798

ENST00000571732

234_255

216.33333333333334

234.0

Region

Disordered

Hgene

YWHAE

chr17:1257504

chr10:81465832

ENST00000264335

234_255

238.33333333333334

256.0

Region

Disordered

Hgene

YWHAE

chr17:1257504

chr10:81465832

ENST00000571732

234_255

216.33333333333334

234.0

Region

Disordered

Top

Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	AA seq	Len(AA seq)

PDB file (276) >>>276.pdbFusion protein BP residue: CIF file (276) >>>276.cif	YWHAE	chr17	1257504	-	NUTM2B	chr10	81465832		MSVFTALPFTTPAPGPAHGPLLVTAGAPPGGPLVLSTFPSTPLVTEQDGC GPSGAGASNVFVQMRTEVGPVKAAQAQTLVLTQAPLVWQAPGALCGGVVC PPPLLLAAAPVVPVMAAQVVGGTQACEGGWSQGLPLPPPPPPAAQLPPIV SQGNAGPWPQGAHGESSLASSQAKAPPDDSCNPRSVYENFRLWQHYKPLA RRHLPQSPDTEALSCFLIPVLRSLARRKPTMTLEEGLWRAMREWQHTSNF DRMIFYEMAEKFLEFEAEEEMQIQKSQWMKGPQCLPPPATPRLEPRGPPA PEVVKQPVYLPSKAGPKAPTACLPPPRPQRPVTKARRPPPRPHRRAETKA RLPPPRPQRPAETKVPEEIPPEVVQEYVDIMEELLGPSLGATGEPEKQRE EGKVKQPQEEDWTPPDPGLLSYIDKLCSQKDFVTKVEAVIHPQFLEELLS	486
3D view using mol* of 276 (AA BP:)


PDB file (277) >>>277.pdbFusion protein BP residue: CIF file (277) >>>277.cif	YWHAE	chr17	1257504	-	NUTM2B	chr10	81465832		MSVFTALPFTTPAPGPAHGPLLVTAGAPPGGPLVLSTFPSTPLVTEQDGC GPSGAGASNVFVQMRTEVGPVKAAQAQTLVLTQAPLVWQAPGALCGGVVC PPPLLLAAAPVVPVMAAQVVGGTQACEGGWSQGLPLPPPPPPAAQLPPIV SQGNAGPWPQGAHGESSLASSQAKAPPDDSCNPRSVYENFRLWQHYKPLA RRHLPQSPDTEALSCFLIPVLRSLARRKPTMTLEEGLWRAMREWQHTSNF DRMIFYEMAEKFLEFEAEEEMQIQKSQWMKGPQCLPPPATPRLEPRGPPA PEVVKQPVYLPSKAGPKAPTACLPPPRPQRPVTKARRPPPRPHRRAETKA RLPPPRPQRPAETKVPEEIPPEVVQEYVDIMEELLGPSLGATGEPEKQRE EGKVKQPQEEDWTPPDPGLLSYIDKLCSQKDFVTKVEAVIHPQFLEELLS	487
3D view using mol* of 277 (AA BP:)


PDB file (598) >>>598.pdbFusion protein BP residue: CIF file (598) >>>598.cif	YWHAE	chr17	1257504	-	NUTM2B	chr10	81465832		MSVFTALPFTTPAPGPAHGPLLVTAGAPPGGPLVLSTFPSTPLVTEQDGC GPSGAGASNVFVQMRTEVGPVKAAQAQTLVLTQAPLVWQAPGALCGGVVC PPPLLLAAAPVVPVMAAQVVGGTQACEGGWSQGLPLPPPPPPAAQLPPIV SQGNAGPWPQGAHGESSLASSQAKAPPDDSCNPRSVYENFRLWQHYKPLA RRHLPQSPDTEALSCFLIPVLRSLARRKPTMTLEEGLWRAMREWQHTSNF DRMIFYEMAEKFLEFEAEEEMQIQKSQWMKGPQCLPPPATPRLEPRGPPA PEVVKQPVYLPSKAGPKAPTACLPPPRPQRPVTKARRPPPRPHRRAETKA RLPPPRPQRPAETKVPEEIPPEVVQEYVDIMEELLGPSLGATGEPEKQRE EGKVKQPQEEDWTPPDPGLLSYIDKLCSQKDFVTKVEAVIHPQFLEELLS PDPQMDFLALSQDLEQEEGLTLAQLVEKRLPPLKEKQHARAAPSRGTARL DSSSSKFAAGQGAERDVPDPQQGVGMETCPPQMTARDSQGRGRAHTGMAR SEDSVVLLGCQDSPGLRAAWPTSPPQDHRPTCPGVGTKDALDLPGGSPVR ESHGLAQGSSEEEELPSLAFLLGSQHKLLPWWLPQSPVPASGLLSPEKWG PQGTHQSPSAERRGLNLAPSPANKAKKRPLFGSLSPAEKTPYPGPGLRVS	735
3D view using mol* of 598 (AA BP:)


PDB file (623) >>>623.pdbFusion protein BP residue: 260 CIF file (623) >>>623.cif	YWHAE	chr17	1257504	-	NUTM2B	chr10	81465798		MRESETLSASIRRADPAGAAAAMDDREDLVYQAKLAEQAERYDEMVESMK KVAGMDVELTVEERNLLSVAYKNVIGARRASWRIISSIEQKEENKGGEDK LKMIREYRQMVETELKLICCDILDVLDKHLIPAANTGESKVFYYKMKGDY HRYLAEFATGNDRKEAAENSLVAYKAASDIAMTELPPTHPIRLGLALNFS VFYYEILNSPDRACRLAKAAFDDAIAELDTLSEESYKDSTLIMQLLRDNL TLWTSDMQGDAYPVLGPGVTANPGTSLSVFTALPFTTPAPGPAHGPLLVT AGAPPGGPLVLSTFPSTPLVTEQDGCGPSGAGASNVFVQMRTEVGPVKAA QAQTLVLTQAPLVWQAPGALCGGVVCPPPLLLAAAPVVPVMAAQVVGGTQ ACEGGWSQGLPLPPPPPPAAQLPPIVSQGNAGPWPQGAHGESSLASSQAK APPDDSCNPRSVYENFRLWQHYKPLARRHLPQSPDTEALSCFLIPVLRSL ARRKPTMTLEEGLWRAMREWQHTSNFDRMIFYEMAEKFLEFEAEEEMQIQ KSQWMKGPQCLPPPATPRLEPRGPPAPEVVKQPVYLPSKAGPKAPTACLP PPRPQRPVTKARRPPPRPHRRAETKARLPPPRPQRPAETKVPEEIPPEVV QEYVDIMEELLGPSLGATGEPEKQREEGKVKQPQEEDWTPPDPGLLSYID KLCSQKDFVTKVEAVIHPQFLEELLSPDPQMDFLALSQDLEQEEGLTLAQ	762
3D view using mol* of 623 (AA BP:260)


PDB file (625)	YWHAE	chr17	1257504	-	NUTM2B	chr10	81465798		MRESETLSASIRRADPAGAAAAMDDREDLVYQAKLAEQAERYDEMVESMK KVAGMDVELTVEERNLLSVAYKNVIGARRASWRIISSIEQKEENKGGEDK LKMIREYRQMVETELKLICCDILDVLDKHLIPAANTGESKVFYYKMKGDY HRYLAEFATGNDRKEAAENSLVAYKAASDIAMTELPPTHPIRLGLALNFS VFYYEILNSPDRACRLAKAAFDDAIAELDTLSEESYKDSTLIMQLLRDNL TLWTSDMQGDAYPVLGPGVTANPGTSLSVFTALPFTTPAPGPAHGPLLVT AGAPPGGPLVLSTFPSTPLVTEQDGCGPSGAGASNVFVQMRTEVGPVKAA QAQTLVLTQAPLVWQAPGALCGGVVCPPPLLLAAAPVVPVMAAQVVGGTQ ACEGGWSQGLPLPPPPPPAAQLPPIVSQGNAGPWPQGAHGESSLASSQAK APPDDSCNPRSVYENFRLWQHYKPLARRHLPQSPDTEALSCFLIPVLRSL ARRKPTMTLEEGLWRAMREWQHTSNFDRMIFYEMAEKFLEFEAEEEMQIQ KSQWMKGPQCLPPPATPRLEPRGPPAPEVVKQPVYLPSKAGPKAPTACLP PPRPQRPVTKARRPPPRPHRRAETKARLPPPRPQRPAETKVPEEIPPEVV QEYVDIMEELLGPSLGATGEPEKQREEGKVKQPQEEDWTPPDPGLLSYID KLCSQKDFVTKVEAVIHPQFLEELLSPDPQMDFLALSQDLEQEEGLTLAQ	763

PDB file (757) >>>757.pdbFusion protein BP residue: 260 CIF file (757) >>>757.cif	YWHAE	chr17	1257504	-	NUTM2B	chr10	81465798		MRESETLSASIRRADPAGAAAAMDDREDLVYQAKLAEQAERYDEMVESMK KVAGMDVELTVEERNLLSVAYKNVIGARRASWRIISSIEQKEENKGGEDK LKMIREYRQMVETELKLICCDILDVLDKHLIPAANTGESKVFYYKMKGDY HRYLAEFATGNDRKEAAENSLVAYKAASDIAMTELPPTHPIRLGLALNFS VFYYEILNSPDRACRLAKAAFDDAIAELDTLSEESYKDSTLIMQLLRDNL TLWTSDMQGDAYPVLGPGVTANPGTSLSVFTALPFTTPAPGPAHGPLLVT AGAPPGGPLVLSTFPSTPLVTEQDGCGPSGAGASNVFVQMRTEVGPVKAA QAQTLVLTQAPLVWQAPGALCGGVVCPPPLLLAAAPVVPVMAAQVVGGTQ ACEGGWSQGLPLPPPPPPAAQLPPIVSQGNAGPWPQGAHGESSLASSQAK APPDDSCNPRSVYENFRLWQHYKPLARRHLPQSPDTEALSCFLIPVLRSL ARRKPTMTLEEGLWRAMREWQHTSNFDRMIFYEMAEKFLEFEAEEEMQIQ KSQWMKGPQCLPPPATPRLEPRGPPAPEVVKQPVYLPSKAGPKAPTACLP PPRPQRPVTKARRPPPRPHRRAETKARLPPPRPQRPAETKVPEEIPPEVV QEYVDIMEELLGPSLGATGEPEKQREEGKVKQPQEEDWTPPDPGLLSYID KLCSQKDFVTKVEAVIHPQFLEELLSPDPQMDFLALSQDLEQEEGLTLAQ LVEKRLPPLKEKQHARAAPSRGTARLDSSSSKFAAGQGAERDVPDPQQGV GMETCPPQMTARDSQGRGRAHTGMARSEDSVVLLGCQDSPGLRAAWPTSP PQDHRPTCPGVGTKDALDLPGGSPVRESHGLAQGSSEEEELPSLAFLLGS QHKLLPWWLPQSPVPASGLLSPEKWGPQGTHQSPSAERRGLNLAPSPANK AKKRPLFGSLSPAEKTPYPGPGLRVSGEQSLTWGLGGPSQSQKRKGDPLV	1011
3D view using mol* of 757 (AA BP:260)

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pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

YWHAE_pLDDT.png

NUTM2B_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

YWHAE_NUTM2B_276_pLDDT.png (AA BP:)

YWHAE_NUTM2B_276_pLDDT_and_active_sites.png (AA BP:)

YWHAE_NUTM2B_276_violinplot.png (AA BP:)

YWHAE_NUTM2B_277_pLDDT.png (AA BP:)

YWHAE_NUTM2B_277_pLDDT_and_active_sites.png (AA BP:)

YWHAE_NUTM2B_277_violinplot.png (AA BP:)

YWHAE_NUTM2B_598_pLDDT.png (AA BP:)

YWHAE_NUTM2B_598_pLDDT_and_active_sites.png (AA BP:)

YWHAE_NUTM2B_598_violinplot.png (AA BP:)

YWHAE_NUTM2B_623_pLDDT.png (AA BP:260)

YWHAE_NUTM2B_623_pLDDT_and_active_sites.png (AA BP:260)

YWHAE_NUTM2B_623_violinplot.png (AA BP:260)

YWHAE_NUTM2B_757_pLDDT.png (AA BP:260)

YWHAE_NUTM2B_757_pLDDT_and_active_sites.png (AA BP:260)

YWHAE_NUTM2B_757_violinplot.png (AA BP:260)

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Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

YWHAE_NUTM2B_276.png

YWHAE_NUTM2B_277.png

YWHAE_NUTM2B_598.png

YWHAE_NUTM2B_623.png

YWHAE_NUTM2B_757.png

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Potential Active Site Information

The potential binding sites of these fusion proteins were identified using SiteMap, a module of the Schrodinger suite.

Fusion AA seq ID in FusionPDB	Site score	Size	D score	Volume	Exposure	Enclosure	Contact	Phobic	Philic	Balance	Don/Acc	Residues
276	1.003	375	1.032	1390.522	0.562	0.683	0.879	0.465	0.974	0.477	1.034	Chain A: 57,58,59,60,61,79,80,81,82,83,84,85,86,87 ,88,89,90,91,176,177,178,179,180,182,184,185,186,1 88,189,216,218,219,220,222,223,224,226,227,228,239 ,242,243,246,247,248,251,258,262,437,438,439,440,4 41,442,444,457,461,464,465,468,469,472
277	1.003	478	1.044	1839.852	0.615	0.662	0.854	0.595	0.9	0.661	0.904	Chain A: 57,58,59,60,61,62,63,64,65,66,75,76,77,78 ,79,80,81,82,83,84,85,86,87,88,89,90,176,177,178,1 79,180,182,184,185,186,188,189,192,216,218,219,220 ,222,223,224,226,227,238,239,242,243,246,247,248,2 51,255,258,261,262,407,408,409,410,411,412,413,414 ,415,416,419,420,423,424,439,444,447,448,450,452,4 53,455,457,458,461,465,468,469,472
598	1.029	211	1.095	932.96	0.745	0.647	0.748	0.732	0.713	1.026	1.238	Chain A: 180,185,186,189,191,192,194,195,196,197,1 98,199,218,219,221,222,223,225,226,231,233,254,257 ,258,261,262,265,266,269,270,273,438,439,440,441,4 44,445,448,460,461,464,465,467,468,475,479,618,620 ,621,622,624,625,626,627,628,629,630,631
623	1.034	775	1.072	2890.118	0.574	0.706	0.883	0.737	0.895	0.824	0.999	Chain A: 34,37,42,60,61,62,64,65,66,68,69,72,73,75 ,76,79,80,81,82,83,84,85,86,87,88,89,90,91,92,94,9 5,100,103,104,107,108,142,145,146,149,150,152,153, 156,157,159,163,189,190,191,194,197,198,201,204,20 5,206,208,210,234,235,237,238,241,242,244,245,248, 249,252,253,256,257,276,277,278,279,280,281,282,28 3,284,285,286,287,308,309,310,311,312,313,314,315, 316,317,318,319,533,536,537,642,643,644,645,646,64 7,649,650,651,653,654,657,658,661
757	1.0314	688	1.0602	2088.87	0.5232	0.7211	0.9067	0.7046	0.9584	0.7352	0.694	Chain A: 68,69,72,73,75,76,79,80,82,83,84,86,87,89 ,90,91,93,108,145,146,149,150,152,153,156,163,194, 197,198,201,204,205,206,208,210,242,245,248,249,25 2,253,256,257,259,260,276,277,278,279,280,281,282, 283,285,453,454,455,456,461,462,464,465,494,495,49 8,502,525,526,529,530,531,533,534,537,538,541,896, 897,899,900,901,902,903,904,905,906,907,908

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Potentially Interacting Small Molecules through Virtual Screening

The FDA-approved small molecule library molecules were subjected to virtual screening using the Glide.

Fusion AA seq ID in FusionPDB

ZINC ID

DrugBank ID

Drug name

Docking score

Glide gscore

Top

Drug information from DrugBank of the top 20 interacting small molecules.

ZINC ID

DrugBank ID

Drug name

Drug type

SMILES

Drug group

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Biochemical Features of Small Molecules

ADME (Absorption, Distribution, Metabolism, and Excretion) of drugs using QikProp(v3.9)

ZINC ID

mol_MW

dipole

SASA

FOSA

FISA

PISA

WPSA

volume

donorHB

accptHB

Human Oral Absorption

Percent Human Oral Absorption

Rule Of Five

Rule Of Three

Top

Drug Toxicity Information

Toxicity information of individual drugs using eToxPred

ZINC ID

Smile

Surface Accessibility

Toxicity

Top

Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

YWHAE

IGF1R, GPRIN2, SORBS2, GRAP2, MAPK7, NDEL1, HDAC4, HDAC5, REM1, BAD, MAP3K10, CDC25C, MAP3K3, MAP3K1, MAP3K2, IRS1, NGFRAP1, SYN2, KCNH2, TNFAIP3, RAF1, CDC25B, TOP2A, TGFB1, CDC25A, Usp8, USP43, POLR3H, HDAC7, MDM4, FOXO3, HIVEP2, LRMP, COX2, MYH10, PNLIP, SSFA2, YWHAB, YWHAZ, YWHAG, ARAF, YWHAH, HDAC9, KIAA0232, TLK1, CHAF1A, CAP2, YWHAQ, RAP1GAP2, SH3BP4, WWTR1, FAM13B, MSL2, ZNF839, RASAL3, WNK1, ENKD1, TBC1D3F, CGNL1, CEP95, ANKHD1-EIF4EBP3, ING1, SRRM2, FAN1, EMD, SAMSN1, EXO1, H2AFX, MYC, PRKAA1, PARD6G, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, DISC1, UBE3A, GAPDH, KAT8, HIST1H3A, HIST1H4A, TCEB3, BRD4, CALM1, FBXO4, CDKN1B, TRAT1, RARRES3, ARRB1, ARRB2, CBL, ACD, POT1, CUL3, CDK2, CUL1, DCUN1D1, NEDD8, PTPN14, MARK3, MARK2, MEX3B, LRRK2, AKT1, ACTA2, CBX3, HNF1A, HSP90AB1, NPM1, ATP5B, ATP5A1, STOML2, CLNS1A, IPO8, KPNB1, RPLP0, RPL6, RPL4, RPS3, RPS8, DNAJA1, EIF4B, EIF3E, EEF1G, EEF1A2, HNRNPA2B1, ILF2, RUVBL2, RCN2, TUBB, TUBB4B, TUBB2B, PRPSAP1, TUBA3E, DDX21, ADH1B, ADH4, AGXT, HIST2H4B, HNRNPA3, HNRNPC, RBMY1A1, SF3B1, PCBP1, RBM10, MAP3K7, TBK1, PPM1B, SPIN1, CDC37, PHB, PRPSAP2, PRPS1, QPCTL, TMPO, C11orf84, HDX, CFAP43, VCP, ATXN1, FN1, VCAM1, BRAF, MAP2K1, PARD3, KIF5B, KLC2, LMO7, TBC1D4, HSPA1A, KLC3, KLC4, KLC1, CLASP2, LIMA1, TSC2, CLASP1, HSPA8, PAK4, RAB11FIP2, MAST3, TBC1D1, KIF1C, OSBPL3, TIAM1, ABLIM1, LARP1, BAIAP2, IRS2, SHROOM2, LSR, KIF1B, RAB11FIP1, MLLT4, MAST2, PFKFB2, CDK18, PKP2, DENND4A, TP53BP2, CGN, ZFP36L2, TUBA1A, KSR1, RABEP1, EIF4E2, CSNK1A1, PDZD11, PRKCI, DCAF7, NADK, USP8, C1QBP, TSC1, REEP1, KIF23, SLC25A6, SRGAP2, FAM53C, TRIP11, BCAR1, CRTC1, RASSF8, CEP250, VAMP8, GRB2, TRIM32, NOS2, IL7R, UBL4A, ITGA4, gag-pol, CBX4, ABL1, MST1R, PAN2, RAD52, BAG3, UL46, GSTA1, FTH1, Wwtr1, Yap1, CDK11B, SRSF1, SRSF6, SRSF4, NOLC1, TRA2B, PLEKHO2, HMHA1, SRSF7, NCBP1, DOK3, VASP, KIAA0930, GAB2, KIAA0226, PIK3R4, SGK223, RCHY1, IGHG1, UVRAG, SRSF2, FBXO6, RASSF2, SAV1, YAP1, PARK2, PAFAH1B2, PPP1R2, PROSC, RAP1GDS1, TMOD3, TNFAIP8, TUBB2A, UBXN1, VCL, XPO1, ALDH7A1, ASNS, ATIC, CAPN2, CAPNS1, EIF5, FERMT2, G6PD, GSS, ISOC1, MCTS1, STK26, OGFOD1, PAK2, PDHB, PDIA4, PTMA, SCPEP1, TBCB, TWF2, UBE2R2, IRS4, SIK3, SIK2, CEP57, TP53, GRB10, DTL, HUWE1, FBXW11, Mdm4, CUL7, OBSL1, CCDC8, MAST1, CDK16, TNK1, BTRC, NKD2, DMTN, TEX33, Numb, EPB41L3, WWC1, HNRNPA1, HSPB1, UNK, ACAT2, CALR, CENPE, MACF1, MAPK14, MCFD2, POLR2D, PSMB2, SHMT2, SNRPD1, ACTR6, HNRNPL, NPM3, PGK1, PSMC1, ZPR1, NTRK1, LCA5, CENPJ, PRICKLE3, MYH11, TSNAX, CCDC88A, CRY1, CRY2, MCM2, Ksr1, CDC5L, ERRFI1, U2AF2, PRDX6, NFATC2, SNF8, ANKZF1, SMAGP, TCEANC, LCP2, METAP2, MAGEB4, CHST11, ZC3HC1, MCM10, DDX54, C8orf59, NAF1, FGF12, GSTM3, STAC, FAM64A, ATP6V0B, FLJ25758, CDC73, WWP2, CDH1, CEP131, PCM1, PPM1H, PTPN3, SSH1, TENC1, SMTNL2, PLEKHG5, SAMD4A, SPATA13, RIN1, TFEB, TESPA1, SAMD4B, FAM163A, CRTC2, FAM189A2, PAK6, RBM3, RAB3IP, CBY1, CEP170, INPP5E, SLC9A1, CYLD, COX15, DLD, DLST, DNM1L, SDHA, SOAT1, VDAC1, TRIM25, BRCA1, BRD1, BRMS1, YLR177W, ACM1, IFNAR1, CFTR, TARDBP, ZNF598, CTNNB1, MEX3C, EGLN3, RIPK4, PTPN4, API5, KRAS, PPP6C, COPE, GRHPR, JUP, PPIE, YAF2, PARD3B, RPA2, NIN, AKAP9, CASK, PRC1, RBM14, UBE2M, RAD18, EFTUD2, AAR2, PIH1D1, TNIP2, RNF31, HAVCR1, BPLF1, ESR2, HEXIM1, MEPCE, PPT1, AGR2, EZH2, RECQL4, KANK1, STUB1, BAP1, PIK3R1, GPC1, Prkaa1, Nav2, KIAA1429, RC3H1, RC3H2, ATG16L1, ACTC1, FAF1, CLIC4, FHL1, FHL2, FHL3, LMO1, LMO2, LMO3, TET2, KCTD15, GBF1, AGRN, BMH1, BMH2, ATXN3, HIBADH, DIABLO, NDUFAB1, ALDH1B1, ALDH2, COQ9, FH, HEXA, HSP90AA1, LDHB, MMP20, RAD23A, TIMM44, UBA1, VBP1, AARS2, ECH1, GRPEL1, IARS2, PAFAH2, PFDN4, SSBP1, DYRK1A, MAPT, CD74, SLC15A3, GEM, DUSP16, MTMR4, PTPDC1, ITFG1, BIRC3, NFX1, nsp7ab, ORF3a, CCDC125, PLEKHA4, PINK1, FANCD2, NGB, ZC3H18, CSK, PDPK1, PRKCE, PRKD1, SHC1, SHOC2, SFN, PHACTR4, MAP3K5, CHAF1B, CAMSAP3, LRCH1, SH2B3, CDK12, TANC2, EPN3, PANK2, MAP3K15, CEP89, FRMD6, THAP11, TTC17, CCNY, ARHGEF19, FAM122B, DAB2IP, FAM110C, LPIN1, PRR5, DNMT1, CDK11A, SRSF10, TBC1D7, NEDD4L, FAM117B, KANK2, DENND4C, RGS12, YWHAE, EMC4, ERC2, APPL2, ANKRD55, ESR1, SNAPIN, EDC3, NEK4, CHMP4C, CCR9, CYSLTR2, RXFP3, KIF14, RMDN3, HNRNPH1, INS, Rnf183, NUPR1, CIC, CCAR2, Apc2, RBM39, LGALS9, ACTN4, BTF3, CAD, CALD1, CDKN2A, COPA, DDB1, DDX6, DHX9, EIF2B1, GOLGA3, HDAC1, JAK1, LTBP1, PPP1R12A, NONO, PA2G4, PAWR, PRPS2, RBBP4, ROCK1, SMARCC2, TRIM21, TAF4, EIF3A, PABPC4, LRRFIP2, MTA2, VPRBP, EIF4A3, MATR3, HDAC6, SAE1, G3BP1, SMC2, IVNS1ABP, SF3B2, FASTKD2, NT5C2, STK38L, MGA, UBR2, CAND1, EFHD2, SHCBP1, SFPQ, TAB3, TAB1, ACAP2, INSIG1, NEDD4, SOD1, IL1B, UFL1, DDRGK1, KRT8, VAPA, FZR1, PAGE4, NUDCD2, LNP1, SNX33, FAM53B, SYNGAP1, CDR2L, GUCA1B, KIAA1211, ARHGEF4, FAM124A, EPB41L1, AFAP1L1, MIIP, PLEKHA3, GAREM, CD28, GPSM3, SIPA1L3, PDE7B, C19orf26, C6orf222, PSD4, MACC1, ZNF395, FAM86C1, SH2D3A, NCKIPSD, KSR2, SPRTN, TRIM26, FBXW7, FGD5, CCNF, HECTD1, NBR1, SQSTM1, MAP1LC3B, SLFN11, RIPK2, PER2,

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
YWHAE
NUTM2B

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs to YWHAE-NUTM2B

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to YWHAE-NUTM2B

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	YWHAE	C0036341	Schizophrenia	4	PSYGENET
Hgene	YWHAE	C0005586	Bipolar Disorder	2	PSYGENET
Hgene	YWHAE	C0206630	Endometrial Stromal Sarcoma	2	ORPHANET
Hgene	YWHAE	C0027627	Neoplasm Metastasis	1	CTD_human
Hgene	YWHAE	C0265219	Miller Dieker syndrome	1	ORPHANET
Hgene	YWHAE	C0334488	Clear cell sarcoma of kidney	1	ORPHANET
Hgene	YWHAE	C2750748	Chromosome 17p13.3 Duplication Syndrome	1	ORPHANET
Hgene	YWHAE	C4707092	Distal 17p13.3 microdeletion syndrome	1	ORPHANET
Tgene	NUTM2B	C0206630	Endometrial Stromal Sarcoma	2	ORPHANET
Tgene	NUTM2B	C0334488	Clear cell sarcoma of kidney	1	ORPHANET