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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:YWHAE-SLC43A2

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: YWHAE-SLC43A2
FusionPDB ID: 100157
FusionGDB2.0 ID: 100157
HgeneTgene
Gene symbol

YWHAE

SLC43A2

Gene ID

7531

124935

Gene nametyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilonsolute carrier family 43 member 2
Synonyms14-3-3E|HEL2|KCIP-1|MDCR|MDSLAT4
Cytomap

17p13.3

17p13.3

Type of geneprotein-codingprotein-coding
Description14-3-3 protein epsilon14-3-3 epsilonepididymis luminal protein 2mitochondrial import stimulation factor L subunitprotein kinase C inhibitor protein-1tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptidetyrosine large neutral amino acids transporter small subunit 4L-type amino acid transporter 4solute carrier family 43 (amino acid system L transporter), member 2
Modification date2020032720200313
UniProtAcc

P62258

.
Ensembl transtripts involved in fusion geneENST idsENST00000264335, ENST00000571732, 
ENST00000573026, ENST00000575977, 
ENST00000498643, 		ENST00000574274, 
ENST00000301335, ENST00000382147, 
ENST00000412517, ENST00000571650, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score28 X 9 X 15=378010 X 10 X 6=600
# samples 4216
** MAII scorelog2(42/3780*10)=-3.16992500144231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(16/600*10)=-1.90689059560852
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: YWHAE [Title/Abstract] AND SLC43A2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)YWHAE(1257505)-SLC43A2(1489345), # samples:2
Anticipated loss of major functional domain due to fusion event.YWHAE-SLC43A2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
YWHAE-SLC43A2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
YWHAE-SLC43A2 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
YWHAE-SLC43A2 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
YWHAE-SLC43A2 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneYWHAE

GO:0000165

MAPK cascade

12917326

HgeneYWHAE

GO:0034605

cellular response to heat

12917326

HgeneYWHAE

GO:0046827

positive regulation of protein export from nucleus

12917326

HgeneYWHAE

GO:0051480

regulation of cytosolic calcium ion concentration

18029012

HgeneYWHAE

GO:0060306

regulation of membrane repolarization

11953308

HgeneYWHAE

GO:1901016

regulation of potassium ion transmembrane transporter activity

11953308

HgeneYWHAE

GO:1901020

negative regulation of calcium ion transmembrane transporter activity

18029012

HgeneYWHAE

GO:1902309

negative regulation of peptidyl-serine dephosphorylation

11953308

HgeneYWHAE

GO:1905913

negative regulation of calcium ion export across plasma membrane

18029012


check buttonFusion gene breakpoints across YWHAE (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across SLC43A2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUADTCGA-55-8094-01AYWHAEchr17

1257505

-SLC43A2chr17

1489345

-
ChimerDB4LUADTCGA-55-8094YWHAEchr17

1257504

-SLC43A2chr17

1489345

-
ChimerDB4OVTCGA-23-1030-01AYWHAEchr17

1303341

-SLC43A2chr17

1496573

-
ChimerDB4OVTCGA-23-1030YWHAEchr17

1303340

-SLC43A2chr17

1496573

-
ChimerDB4OVTCGA-29-1774-01AYWHAEchr17

1257505

-SLC43A2chr17

1496573

-
ChimerDB4OVTCGA-29-1774YWHAEchr17

1257504

-SLC43A2chr17

1496573

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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000264335YWHAEchr171257504-ENST00000301335SLC43A2chr171489345-79529832021614470
ENST00000264335YWHAEchr171257504-ENST00000571650SLC43A2chr171489345-28409832021614470
ENST00000264335YWHAEchr171257504-ENST00000382147SLC43A2chr171489345-28159832021092296
ENST00000264335YWHAEchr171257504-ENST00000412517SLC43A2chr171489345-17189832021614470
ENST00000264335YWHAEchr171303340-ENST00000301335SLC43A2chr171496573-78783322008266580
ENST00000264335YWHAEchr171303340-ENST00000571650SLC43A2chr171496573-27783322020266584
ENST00000264335YWHAEchr171303340-ENST00000382147SLC43A2chr171496573-27533322020266584
ENST00000264335YWHAEchr171303340-ENST00000412517SLC43A2chr171496573-16443321609266447
ENST00000573026YWHAEchr171303340-ENST00000301335SLC43A2chr171496573-7681135181169580
ENST00000573026YWHAEchr171303340-ENST00000571650SLC43A2chr171496573-2581135182369584
ENST00000573026YWHAEchr171303340-ENST00000382147SLC43A2chr171496573-2556135182369584
ENST00000573026YWHAEchr171303340-ENST00000412517SLC43A2chr171496573-1447135141269447
ENST00000575977YWHAEchr171303340-ENST00000301335SLC43A2chr171496573-77141681844102580
ENST00000575977YWHAEchr171303340-ENST00000571650SLC43A2chr171496573-26141681856102584
ENST00000575977YWHAEchr171303340-ENST00000382147SLC43A2chr171496573-25891681856102584
ENST00000575977YWHAEchr171303340-ENST00000412517SLC43A2chr171496573-14801681445102447
ENST00000264335YWHAEchr171257505-ENST00000301335SLC43A2chr171489345-79529832021614470
ENST00000264335YWHAEchr171257505-ENST00000571650SLC43A2chr171489345-28409832021614470
ENST00000264335YWHAEchr171257505-ENST00000382147SLC43A2chr171489345-28159832021092296
ENST00000264335YWHAEchr171257505-ENST00000412517SLC43A2chr171489345-17189832021614470
ENST00000264335YWHAEchr171303341-ENST00000301335SLC43A2chr171496573-78783322008266580
ENST00000264335YWHAEchr171303341-ENST00000571650SLC43A2chr171496573-27783322020266584
ENST00000264335YWHAEchr171303341-ENST00000382147SLC43A2chr171496573-27533322020266584
ENST00000264335YWHAEchr171303341-ENST00000412517SLC43A2chr171496573-16443321609266447
ENST00000573026YWHAEchr171303341-ENST00000301335SLC43A2chr171496573-7681135181169580
ENST00000573026YWHAEchr171303341-ENST00000571650SLC43A2chr171496573-2581135182369584
ENST00000573026YWHAEchr171303341-ENST00000382147SLC43A2chr171496573-2556135182369584
ENST00000573026YWHAEchr171303341-ENST00000412517SLC43A2chr171496573-1447135141269447
ENST00000575977YWHAEchr171303341-ENST00000301335SLC43A2chr171496573-77141681844102580
ENST00000575977YWHAEchr171303341-ENST00000571650SLC43A2chr171496573-26141681856102584
ENST00000575977YWHAEchr171303341-ENST00000382147SLC43A2chr171496573-25891681856102584
ENST00000575977YWHAEchr171303341-ENST00000412517SLC43A2chr171496573-14801681445102447

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000264335ENST00000301335YWHAEchr171257504-SLC43A2chr171489345-0.0031574590.9968425
ENST00000264335ENST00000571650YWHAEchr171257504-SLC43A2chr171489345-0.0042988450.99570113
ENST00000264335ENST00000382147YWHAEchr171257504-SLC43A2chr171489345-0.0016845590.99831545
ENST00000264335ENST00000412517YWHAEchr171257504-SLC43A2chr171489345-0.00368840.9963116
ENST00000264335ENST00000301335YWHAEchr171303340-SLC43A2chr171496573-0.0290818810.97091806
ENST00000264335ENST00000571650YWHAEchr171303340-SLC43A2chr171496573-0.039046180.96095383
ENST00000264335ENST00000382147YWHAEchr171303340-SLC43A2chr171496573-0.0455442440.9544558
ENST00000264335ENST00000412517YWHAEchr171303340-SLC43A2chr171496573-0.041616740.95838326
ENST00000573026ENST00000301335YWHAEchr171303340-SLC43A2chr171496573-0.027945280.9720548
ENST00000573026ENST00000571650YWHAEchr171303340-SLC43A2chr171496573-0.037969880.9620301
ENST00000573026ENST00000382147YWHAEchr171303340-SLC43A2chr171496573-0.044842010.955158
ENST00000573026ENST00000412517YWHAEchr171303340-SLC43A2chr171496573-0.042249760.95775026
ENST00000575977ENST00000301335YWHAEchr171303340-SLC43A2chr171496573-0.0283152760.97168475
ENST00000575977ENST00000571650YWHAEchr171303340-SLC43A2chr171496573-0.03783810.96216184
ENST00000575977ENST00000382147YWHAEchr171303340-SLC43A2chr171496573-0.0448513250.9551487
ENST00000575977ENST00000412517YWHAEchr171303340-SLC43A2chr171496573-0.0410899220.9589101
ENST00000264335ENST00000301335YWHAEchr171257505-SLC43A2chr171489345-0.0031574590.9968425
ENST00000264335ENST00000571650YWHAEchr171257505-SLC43A2chr171489345-0.0042988450.99570113
ENST00000264335ENST00000382147YWHAEchr171257505-SLC43A2chr171489345-0.0016845590.99831545
ENST00000264335ENST00000412517YWHAEchr171257505-SLC43A2chr171489345-0.00368840.9963116
ENST00000264335ENST00000301335YWHAEchr171303341-SLC43A2chr171496573-0.0290818810.97091806
ENST00000264335ENST00000571650YWHAEchr171303341-SLC43A2chr171496573-0.039046180.96095383
ENST00000264335ENST00000382147YWHAEchr171303341-SLC43A2chr171496573-0.0455442440.9544558
ENST00000264335ENST00000412517YWHAEchr171303341-SLC43A2chr171496573-0.041616740.95838326
ENST00000573026ENST00000301335YWHAEchr171303341-SLC43A2chr171496573-0.027945280.9720548
ENST00000573026ENST00000571650YWHAEchr171303341-SLC43A2chr171496573-0.037969880.9620301
ENST00000573026ENST00000382147YWHAEchr171303341-SLC43A2chr171496573-0.044842010.955158
ENST00000573026ENST00000412517YWHAEchr171303341-SLC43A2chr171496573-0.042249760.95775026
ENST00000575977ENST00000301335YWHAEchr171303341-SLC43A2chr171496573-0.0283152760.97168475
ENST00000575977ENST00000571650YWHAEchr171303341-SLC43A2chr171496573-0.03783810.96216184
ENST00000575977ENST00000382147YWHAEchr171303341-SLC43A2chr171496573-0.0448513250.9551487
ENST00000575977ENST00000412517YWHAEchr171303341-SLC43A2chr171496573-0.0410899220.9589101

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>100157_100157_1_YWHAE-SLC43A2_YWHAE_chr17_1257504_ENST00000264335_SLC43A2_chr17_1489345_ENST00000301335_length(amino acids)=470AA_BP=260
MRESETLSASIRRADPAGAAAAMDDREDLVYQAKLAEQAERYDEMVESMKKVAGMDVELTVEERNLLSVAYKNVIGARRASWRIISSIEQ
KEENKGGEDKLKMIREYRQMVETELKLICCDILDVLDKHLIPAANTGESKVFYYKMKGDYHRYLAEFATGNDRKEAAENSLVAYKAASDI
AMTELPPTHPIRLGLALNFSVFYYEILNSPDRACRLAKAAFDDAIAELDTLSEESYKDSTLIMQLLRDNLTLWTSDMQGDVGLYTSIFGV
LQLLCLLTAPVIGYIMDWRLKECEDASEEPEEKDANQGEKKKKKRDRQIQKITNAMRAFAFTNLLLVGFGVTCLIPNLPLQILSFILHTI
VRGFIHSAVGGLYAAVYPSTQFGSLTGLQSLISALFALLQQPLFLAMMGPLQGDPLWVNVGLLLLSLLGFCLPLYLICYRRQLERQLQQR

--------------------------------------------------------------

>100157_100157_2_YWHAE-SLC43A2_YWHAE_chr17_1257504_ENST00000264335_SLC43A2_chr17_1489345_ENST00000382147_length(amino acids)=296AA_BP=
MRESETLSASIRRADPAGAAAAMDDREDLVYQAKLAEQAERYDEMVESMKKVAGMDVELTVEERNLLSVAYKNVIGARRASWRIISSIEQ
KEENKGGEDKLKMIREYRQMVETELKLICCDILDVLDKHLIPAANTGESKVFYYKMKGDYHRYLAEFATGNDRKEAAENSLVAYKAASDI
AMTELPPTHPIRLGLALNFSVFYYEILNSPDRACRLAKAAFDDAIAELDTLSEESYKDSTLIMQLLRDNLTLWTSDMQGDGERGAAPSQP

--------------------------------------------------------------

>100157_100157_3_YWHAE-SLC43A2_YWHAE_chr17_1257504_ENST00000264335_SLC43A2_chr17_1489345_ENST00000412517_length(amino acids)=470AA_BP=260
MRESETLSASIRRADPAGAAAAMDDREDLVYQAKLAEQAERYDEMVESMKKVAGMDVELTVEERNLLSVAYKNVIGARRASWRIISSIEQ
KEENKGGEDKLKMIREYRQMVETELKLICCDILDVLDKHLIPAANTGESKVFYYKMKGDYHRYLAEFATGNDRKEAAENSLVAYKAASDI
AMTELPPTHPIRLGLALNFSVFYYEILNSPDRACRLAKAAFDDAIAELDTLSEESYKDSTLIMQLLRDNLTLWTSDMQGDVGLYTSIFGV
LQLLCLLTAPVIGYIMDWRLKECEDASEEPEEKDANQGEKKKKKRDRQIQKITNAMRAFAFTNLLLVGFGVTCLIPNLPLQILSFILHTI
VRGFIHSAVGGLYAAVYPSTQFGSLTGLQSLISALFALLQQPLFLAMMGPLQGDPLWVNVGLLLLSLLGFCLPLYLICYRRQLERQLQQR

--------------------------------------------------------------

>100157_100157_4_YWHAE-SLC43A2_YWHAE_chr17_1257504_ENST00000264335_SLC43A2_chr17_1489345_ENST00000571650_length(amino acids)=470AA_BP=260
MRESETLSASIRRADPAGAAAAMDDREDLVYQAKLAEQAERYDEMVESMKKVAGMDVELTVEERNLLSVAYKNVIGARRASWRIISSIEQ
KEENKGGEDKLKMIREYRQMVETELKLICCDILDVLDKHLIPAANTGESKVFYYKMKGDYHRYLAEFATGNDRKEAAENSLVAYKAASDI
AMTELPPTHPIRLGLALNFSVFYYEILNSPDRACRLAKAAFDDAIAELDTLSEESYKDSTLIMQLLRDNLTLWTSDMQGDVGLYTSIFGV
LQLLCLLTAPVIGYIMDWRLKECEDASEEPEEKDANQGEKKKKKRDRQIQKITNAMRAFAFTNLLLVGFGVTCLIPNLPLQILSFILHTI
VRGFIHSAVGGLYAAVYPSTQFGSLTGLQSLISALFALLQQPLFLAMMGPLQGDPLWVNVGLLLLSLLGFCLPLYLICYRRQLERQLQQR

--------------------------------------------------------------

>100157_100157_5_YWHAE-SLC43A2_YWHAE_chr17_1257505_ENST00000264335_SLC43A2_chr17_1489345_ENST00000301335_length(amino acids)=470AA_BP=260
MRESETLSASIRRADPAGAAAAMDDREDLVYQAKLAEQAERYDEMVESMKKVAGMDVELTVEERNLLSVAYKNVIGARRASWRIISSIEQ
KEENKGGEDKLKMIREYRQMVETELKLICCDILDVLDKHLIPAANTGESKVFYYKMKGDYHRYLAEFATGNDRKEAAENSLVAYKAASDI
AMTELPPTHPIRLGLALNFSVFYYEILNSPDRACRLAKAAFDDAIAELDTLSEESYKDSTLIMQLLRDNLTLWTSDMQGDVGLYTSIFGV
LQLLCLLTAPVIGYIMDWRLKECEDASEEPEEKDANQGEKKKKKRDRQIQKITNAMRAFAFTNLLLVGFGVTCLIPNLPLQILSFILHTI
VRGFIHSAVGGLYAAVYPSTQFGSLTGLQSLISALFALLQQPLFLAMMGPLQGDPLWVNVGLLLLSLLGFCLPLYLICYRRQLERQLQQR

--------------------------------------------------------------

>100157_100157_6_YWHAE-SLC43A2_YWHAE_chr17_1257505_ENST00000264335_SLC43A2_chr17_1489345_ENST00000382147_length(amino acids)=296AA_BP=
MRESETLSASIRRADPAGAAAAMDDREDLVYQAKLAEQAERYDEMVESMKKVAGMDVELTVEERNLLSVAYKNVIGARRASWRIISSIEQ
KEENKGGEDKLKMIREYRQMVETELKLICCDILDVLDKHLIPAANTGESKVFYYKMKGDYHRYLAEFATGNDRKEAAENSLVAYKAASDI
AMTELPPTHPIRLGLALNFSVFYYEILNSPDRACRLAKAAFDDAIAELDTLSEESYKDSTLIMQLLRDNLTLWTSDMQGDGERGAAPSQP

--------------------------------------------------------------

>100157_100157_7_YWHAE-SLC43A2_YWHAE_chr17_1257505_ENST00000264335_SLC43A2_chr17_1489345_ENST00000412517_length(amino acids)=470AA_BP=260
MRESETLSASIRRADPAGAAAAMDDREDLVYQAKLAEQAERYDEMVESMKKVAGMDVELTVEERNLLSVAYKNVIGARRASWRIISSIEQ
KEENKGGEDKLKMIREYRQMVETELKLICCDILDVLDKHLIPAANTGESKVFYYKMKGDYHRYLAEFATGNDRKEAAENSLVAYKAASDI
AMTELPPTHPIRLGLALNFSVFYYEILNSPDRACRLAKAAFDDAIAELDTLSEESYKDSTLIMQLLRDNLTLWTSDMQGDVGLYTSIFGV
LQLLCLLTAPVIGYIMDWRLKECEDASEEPEEKDANQGEKKKKKRDRQIQKITNAMRAFAFTNLLLVGFGVTCLIPNLPLQILSFILHTI
VRGFIHSAVGGLYAAVYPSTQFGSLTGLQSLISALFALLQQPLFLAMMGPLQGDPLWVNVGLLLLSLLGFCLPLYLICYRRQLERQLQQR

--------------------------------------------------------------

>100157_100157_8_YWHAE-SLC43A2_YWHAE_chr17_1257505_ENST00000264335_SLC43A2_chr17_1489345_ENST00000571650_length(amino acids)=470AA_BP=260
MRESETLSASIRRADPAGAAAAMDDREDLVYQAKLAEQAERYDEMVESMKKVAGMDVELTVEERNLLSVAYKNVIGARRASWRIISSIEQ
KEENKGGEDKLKMIREYRQMVETELKLICCDILDVLDKHLIPAANTGESKVFYYKMKGDYHRYLAEFATGNDRKEAAENSLVAYKAASDI
AMTELPPTHPIRLGLALNFSVFYYEILNSPDRACRLAKAAFDDAIAELDTLSEESYKDSTLIMQLLRDNLTLWTSDMQGDVGLYTSIFGV
LQLLCLLTAPVIGYIMDWRLKECEDASEEPEEKDANQGEKKKKKRDRQIQKITNAMRAFAFTNLLLVGFGVTCLIPNLPLQILSFILHTI
VRGFIHSAVGGLYAAVYPSTQFGSLTGLQSLISALFALLQQPLFLAMMGPLQGDPLWVNVGLLLLSLLGFCLPLYLICYRRQLERQLQQR

--------------------------------------------------------------

>100157_100157_9_YWHAE-SLC43A2_YWHAE_chr17_1303340_ENST00000264335_SLC43A2_chr17_1496573_ENST00000301335_length(amino acids)=580AA_BP=1
MAGEGVGARRGRDSASLCPQAGTAVGMQPRGRWQAGDGSPLCFGKRQNPDTGGRAPACRAFLAPAAGTTETPGPGSPGGGRAKSGQPLRS
AGENARVRGPLPSFHHRAPRQGPGRERERWHGDGEGPGGAWGTLEGQDRGQSLKHRQETAVPRRQPLHEGLLVGRAVDFEEEFVILLPLL
QLPLQLAPVADQVEREAEAQQAEKEQPHVHPQRVSLERTHHGQKQRLLQKGEERADQRLQSREAAELGGGVHGSVQAPDSGVDESSHDCV
QDEGEDLERQVGNEAGHPKAHEQQVGEGEGPHGISDLLDLPVPLLLFLLALVGVFLLGLLGGVFTLLQPPVHDVANDGGRQQAQQLEHAE
DGGVEANCLLVAADQELEDVVHSPHVEDEPQLRDAHGDQAEQQDGAEHAVHEGGGHCGIRLALHLQVDGGQAQLVALLQRHLLLGTPHGA
AHTQAPAHRGHLLVELLPCDLVVKAQPAELDLHRVVHVLRPREGLKGPVKEAVEENQPGAAGPDHEDDDEGDTSIIDELDSWKGDCRGGV

--------------------------------------------------------------

>100157_100157_10_YWHAE-SLC43A2_YWHAE_chr17_1303340_ENST00000264335_SLC43A2_chr17_1496573_ENST00000382147_length(amino acids)=584AA_BP=1
MAGEGVGARRGRDSASLCPQAGTAVGMQPRGRWQAGDGSPLCFGKRQNPDTGGRAPACRAFLAPAAGTTETPGPGSPGGGRAKSGQPLRS
AGENARVRGPLPSFHHRAPRQGPGRERERWHGDGEGPGGAWGTLEGQDRGQSLKHRQETAVPRRQPLHEGLLVGRAVDFEEEFVILLPLL
QLPLQLAPVADQVEREAEAQQAEKEQPHVHPQRVSLERTHHGQKQRLLQKGEERADQRLQSREAAELGGGVHGSVQAPDSGVDESSHDCV
QDEGEDLERQVGNEAGHPKAHEQQVGEGEGPHGISDLLDLPVPLLLFLLALVGVFLLGLLGGVFTLLQPPVHDVANDGGRQQAQQLEHAE
DGGVEANCGGSCLLVAADQELEDVVHSPHVEDEPQLRDAHGDQAEQQDGAEHAVHEGGGHCGIRLALHLQVDGGQAQLVALLQRHLLLGT
PHGAAHTQAPAHRGHLLVELLPCDLVVKAQPAELDLHRVVHVLRPREGLKGPVKEAVEENQPGAAGPDHEDDDEGDTSIIDELDSWKGDC

--------------------------------------------------------------

>100157_100157_11_YWHAE-SLC43A2_YWHAE_chr17_1303340_ENST00000264335_SLC43A2_chr17_1496573_ENST00000412517_length(amino acids)=447AA_BP=1
MEGQDRGQSLKHRQETAVPRRQPLHEGLLVGRAVDFEEEFVILLPLLQLPLQLAPVADQVEREAEAQQAEKEQPHVHPQRVSLERTHHGQ
KQRLLQKGEERADQRLQSREAAELGGGVHGSVQAPDSGVDESSHDCVQDEGEDLERQVGNEAGHPKAHEQQVGEGEGPHGISDLLDLPVP
LLLFLLALVGVFLLGLLGGVFTLLQPPVHDVANDGGRQQAQQLEHAEDGGVEANCLLVAADQELEDVVHSPHVEDEPQLRDAHGDQAEQQ
DGAEHAVHEGGGHCGIRLALHLQVDGGQAQLVALLQRHLLLGTPHGAAHTQAPAHRGHLLVELLPCDLVVKAQPAELDLHRVVHVLRPRE

--------------------------------------------------------------

>100157_100157_12_YWHAE-SLC43A2_YWHAE_chr17_1303340_ENST00000264335_SLC43A2_chr17_1496573_ENST00000571650_length(amino acids)=584AA_BP=1
MAGEGVGARRGRDSASLCPQAGTAVGMQPRGRWQAGDGSPLCFGKRQNPDTGGRAPACRAFLAPAAGTTETPGPGSPGGGRAKSGQPLRS
AGENARVRGPLPSFHHRAPRQGPGRERERWHGDGEGPGGAWGTLEGQDRGQSLKHRQETAVPRRQPLHEGLLVGRAVDFEEEFVILLPLL
QLPLQLAPVADQVEREAEAQQAEKEQPHVHPQRVSLERTHHGQKQRLLQKGEERADQRLQSREAAELGGGVHGSVQAPDSGVDESSHDCV
QDEGEDLERQVGNEAGHPKAHEQQVGEGEGPHGISDLLDLPVPLLLFLLALVGVFLLGLLGGVFTLLQPPVHDVANDGGRQQAQQLEHAE
DGGVEANRGHHCLLVAADQELEDVVHSPHVEDEPQLRDAHGDQAEQQDGAEHAVHEGGGHCGIRLALHLQVDGGQAQLVALLQRHLLLGT
PHGAAHTQAPAHRGHLLVELLPCDLVVKAQPAELDLHRVVHVLRPREGLKGPVKEAVEENQPGAAGPDHEDDDEGDTSIIDELDSWKGDC

--------------------------------------------------------------

>100157_100157_13_YWHAE-SLC43A2_YWHAE_chr17_1303340_ENST00000573026_SLC43A2_chr17_1496573_ENST00000301335_length(amino acids)=580AA_BP=1
MAGEGVGARRGRDSASLCPQAGTAVGMQPRGRWQAGDGSPLCFGKRQNPDTGGRAPACRAFLAPAAGTTETPGPGSPGGGRAKSGQPLRS
AGENARVRGPLPSFHHRAPRQGPGRERERWHGDGEGPGGAWGTLEGQDRGQSLKHRQETAVPRRQPLHEGLLVGRAVDFEEEFVILLPLL
QLPLQLAPVADQVEREAEAQQAEKEQPHVHPQRVSLERTHHGQKQRLLQKGEERADQRLQSREAAELGGGVHGSVQAPDSGVDESSHDCV
QDEGEDLERQVGNEAGHPKAHEQQVGEGEGPHGISDLLDLPVPLLLFLLALVGVFLLGLLGGVFTLLQPPVHDVANDGGRQQAQQLEHAE
DGGVEANCLLVAADQELEDVVHSPHVEDEPQLRDAHGDQAEQQDGAEHAVHEGGGHCGIRLALHLQVDGGQAQLVALLQRHLLLGTPHGA
AHTQAPAHRGHLLVELLPCDLVVKAQPAELDLHRVVHVLRPREGLKGPVKEAVEENQPGAAGPDHEDDDEGDTSIIDELDSWKGDCRGGV

--------------------------------------------------------------

>100157_100157_14_YWHAE-SLC43A2_YWHAE_chr17_1303340_ENST00000573026_SLC43A2_chr17_1496573_ENST00000382147_length(amino acids)=584AA_BP=1
MAGEGVGARRGRDSASLCPQAGTAVGMQPRGRWQAGDGSPLCFGKRQNPDTGGRAPACRAFLAPAAGTTETPGPGSPGGGRAKSGQPLRS
AGENARVRGPLPSFHHRAPRQGPGRERERWHGDGEGPGGAWGTLEGQDRGQSLKHRQETAVPRRQPLHEGLLVGRAVDFEEEFVILLPLL
QLPLQLAPVADQVEREAEAQQAEKEQPHVHPQRVSLERTHHGQKQRLLQKGEERADQRLQSREAAELGGGVHGSVQAPDSGVDESSHDCV
QDEGEDLERQVGNEAGHPKAHEQQVGEGEGPHGISDLLDLPVPLLLFLLALVGVFLLGLLGGVFTLLQPPVHDVANDGGRQQAQQLEHAE
DGGVEANCGGSCLLVAADQELEDVVHSPHVEDEPQLRDAHGDQAEQQDGAEHAVHEGGGHCGIRLALHLQVDGGQAQLVALLQRHLLLGT
PHGAAHTQAPAHRGHLLVELLPCDLVVKAQPAELDLHRVVHVLRPREGLKGPVKEAVEENQPGAAGPDHEDDDEGDTSIIDELDSWKGDC

--------------------------------------------------------------

>100157_100157_15_YWHAE-SLC43A2_YWHAE_chr17_1303340_ENST00000573026_SLC43A2_chr17_1496573_ENST00000412517_length(amino acids)=447AA_BP=1
MEGQDRGQSLKHRQETAVPRRQPLHEGLLVGRAVDFEEEFVILLPLLQLPLQLAPVADQVEREAEAQQAEKEQPHVHPQRVSLERTHHGQ
KQRLLQKGEERADQRLQSREAAELGGGVHGSVQAPDSGVDESSHDCVQDEGEDLERQVGNEAGHPKAHEQQVGEGEGPHGISDLLDLPVP
LLLFLLALVGVFLLGLLGGVFTLLQPPVHDVANDGGRQQAQQLEHAEDGGVEANCLLVAADQELEDVVHSPHVEDEPQLRDAHGDQAEQQ
DGAEHAVHEGGGHCGIRLALHLQVDGGQAQLVALLQRHLLLGTPHGAAHTQAPAHRGHLLVELLPCDLVVKAQPAELDLHRVVHVLRPRE

--------------------------------------------------------------

>100157_100157_16_YWHAE-SLC43A2_YWHAE_chr17_1303340_ENST00000573026_SLC43A2_chr17_1496573_ENST00000571650_length(amino acids)=584AA_BP=1
MAGEGVGARRGRDSASLCPQAGTAVGMQPRGRWQAGDGSPLCFGKRQNPDTGGRAPACRAFLAPAAGTTETPGPGSPGGGRAKSGQPLRS
AGENARVRGPLPSFHHRAPRQGPGRERERWHGDGEGPGGAWGTLEGQDRGQSLKHRQETAVPRRQPLHEGLLVGRAVDFEEEFVILLPLL
QLPLQLAPVADQVEREAEAQQAEKEQPHVHPQRVSLERTHHGQKQRLLQKGEERADQRLQSREAAELGGGVHGSVQAPDSGVDESSHDCV
QDEGEDLERQVGNEAGHPKAHEQQVGEGEGPHGISDLLDLPVPLLLFLLALVGVFLLGLLGGVFTLLQPPVHDVANDGGRQQAQQLEHAE
DGGVEANRGHHCLLVAADQELEDVVHSPHVEDEPQLRDAHGDQAEQQDGAEHAVHEGGGHCGIRLALHLQVDGGQAQLVALLQRHLLLGT
PHGAAHTQAPAHRGHLLVELLPCDLVVKAQPAELDLHRVVHVLRPREGLKGPVKEAVEENQPGAAGPDHEDDDEGDTSIIDELDSWKGDC

--------------------------------------------------------------

>100157_100157_17_YWHAE-SLC43A2_YWHAE_chr17_1303340_ENST00000575977_SLC43A2_chr17_1496573_ENST00000301335_length(amino acids)=580AA_BP=1
MAGEGVGARRGRDSASLCPQAGTAVGMQPRGRWQAGDGSPLCFGKRQNPDTGGRAPACRAFLAPAAGTTETPGPGSPGGGRAKSGQPLRS
AGENARVRGPLPSFHHRAPRQGPGRERERWHGDGEGPGGAWGTLEGQDRGQSLKHRQETAVPRRQPLHEGLLVGRAVDFEEEFVILLPLL
QLPLQLAPVADQVEREAEAQQAEKEQPHVHPQRVSLERTHHGQKQRLLQKGEERADQRLQSREAAELGGGVHGSVQAPDSGVDESSHDCV
QDEGEDLERQVGNEAGHPKAHEQQVGEGEGPHGISDLLDLPVPLLLFLLALVGVFLLGLLGGVFTLLQPPVHDVANDGGRQQAQQLEHAE
DGGVEANCLLVAADQELEDVVHSPHVEDEPQLRDAHGDQAEQQDGAEHAVHEGGGHCGIRLALHLQVDGGQAQLVALLQRHLLLGTPHGA
AHTQAPAHRGHLLVELLPCDLVVKAQPAELDLHRVVHVLRPREGLKGPVKEAVEENQPGAAGPDHEDDDEGDTSIIDELDSWKGDCRGGV

--------------------------------------------------------------

>100157_100157_18_YWHAE-SLC43A2_YWHAE_chr17_1303340_ENST00000575977_SLC43A2_chr17_1496573_ENST00000382147_length(amino acids)=584AA_BP=1
MAGEGVGARRGRDSASLCPQAGTAVGMQPRGRWQAGDGSPLCFGKRQNPDTGGRAPACRAFLAPAAGTTETPGPGSPGGGRAKSGQPLRS
AGENARVRGPLPSFHHRAPRQGPGRERERWHGDGEGPGGAWGTLEGQDRGQSLKHRQETAVPRRQPLHEGLLVGRAVDFEEEFVILLPLL
QLPLQLAPVADQVEREAEAQQAEKEQPHVHPQRVSLERTHHGQKQRLLQKGEERADQRLQSREAAELGGGVHGSVQAPDSGVDESSHDCV
QDEGEDLERQVGNEAGHPKAHEQQVGEGEGPHGISDLLDLPVPLLLFLLALVGVFLLGLLGGVFTLLQPPVHDVANDGGRQQAQQLEHAE
DGGVEANCGGSCLLVAADQELEDVVHSPHVEDEPQLRDAHGDQAEQQDGAEHAVHEGGGHCGIRLALHLQVDGGQAQLVALLQRHLLLGT
PHGAAHTQAPAHRGHLLVELLPCDLVVKAQPAELDLHRVVHVLRPREGLKGPVKEAVEENQPGAAGPDHEDDDEGDTSIIDELDSWKGDC

--------------------------------------------------------------

>100157_100157_19_YWHAE-SLC43A2_YWHAE_chr17_1303340_ENST00000575977_SLC43A2_chr17_1496573_ENST00000412517_length(amino acids)=447AA_BP=1
MEGQDRGQSLKHRQETAVPRRQPLHEGLLVGRAVDFEEEFVILLPLLQLPLQLAPVADQVEREAEAQQAEKEQPHVHPQRVSLERTHHGQ
KQRLLQKGEERADQRLQSREAAELGGGVHGSVQAPDSGVDESSHDCVQDEGEDLERQVGNEAGHPKAHEQQVGEGEGPHGISDLLDLPVP
LLLFLLALVGVFLLGLLGGVFTLLQPPVHDVANDGGRQQAQQLEHAEDGGVEANCLLVAADQELEDVVHSPHVEDEPQLRDAHGDQAEQQ
DGAEHAVHEGGGHCGIRLALHLQVDGGQAQLVALLQRHLLLGTPHGAAHTQAPAHRGHLLVELLPCDLVVKAQPAELDLHRVVHVLRPRE

--------------------------------------------------------------

>100157_100157_20_YWHAE-SLC43A2_YWHAE_chr17_1303340_ENST00000575977_SLC43A2_chr17_1496573_ENST00000571650_length(amino acids)=584AA_BP=1
MAGEGVGARRGRDSASLCPQAGTAVGMQPRGRWQAGDGSPLCFGKRQNPDTGGRAPACRAFLAPAAGTTETPGPGSPGGGRAKSGQPLRS
AGENARVRGPLPSFHHRAPRQGPGRERERWHGDGEGPGGAWGTLEGQDRGQSLKHRQETAVPRRQPLHEGLLVGRAVDFEEEFVILLPLL
QLPLQLAPVADQVEREAEAQQAEKEQPHVHPQRVSLERTHHGQKQRLLQKGEERADQRLQSREAAELGGGVHGSVQAPDSGVDESSHDCV
QDEGEDLERQVGNEAGHPKAHEQQVGEGEGPHGISDLLDLPVPLLLFLLALVGVFLLGLLGGVFTLLQPPVHDVANDGGRQQAQQLEHAE
DGGVEANRGHHCLLVAADQELEDVVHSPHVEDEPQLRDAHGDQAEQQDGAEHAVHEGGGHCGIRLALHLQVDGGQAQLVALLQRHLLLGT
PHGAAHTQAPAHRGHLLVELLPCDLVVKAQPAELDLHRVVHVLRPREGLKGPVKEAVEENQPGAAGPDHEDDDEGDTSIIDELDSWKGDC

--------------------------------------------------------------

>100157_100157_21_YWHAE-SLC43A2_YWHAE_chr17_1303341_ENST00000264335_SLC43A2_chr17_1496573_ENST00000301335_length(amino acids)=580AA_BP=1
MAGEGVGARRGRDSASLCPQAGTAVGMQPRGRWQAGDGSPLCFGKRQNPDTGGRAPACRAFLAPAAGTTETPGPGSPGGGRAKSGQPLRS
AGENARVRGPLPSFHHRAPRQGPGRERERWHGDGEGPGGAWGTLEGQDRGQSLKHRQETAVPRRQPLHEGLLVGRAVDFEEEFVILLPLL
QLPLQLAPVADQVEREAEAQQAEKEQPHVHPQRVSLERTHHGQKQRLLQKGEERADQRLQSREAAELGGGVHGSVQAPDSGVDESSHDCV
QDEGEDLERQVGNEAGHPKAHEQQVGEGEGPHGISDLLDLPVPLLLFLLALVGVFLLGLLGGVFTLLQPPVHDVANDGGRQQAQQLEHAE
DGGVEANCLLVAADQELEDVVHSPHVEDEPQLRDAHGDQAEQQDGAEHAVHEGGGHCGIRLALHLQVDGGQAQLVALLQRHLLLGTPHGA
AHTQAPAHRGHLLVELLPCDLVVKAQPAELDLHRVVHVLRPREGLKGPVKEAVEENQPGAAGPDHEDDDEGDTSIIDELDSWKGDCRGGV

--------------------------------------------------------------

>100157_100157_22_YWHAE-SLC43A2_YWHAE_chr17_1303341_ENST00000264335_SLC43A2_chr17_1496573_ENST00000382147_length(amino acids)=584AA_BP=1
MAGEGVGARRGRDSASLCPQAGTAVGMQPRGRWQAGDGSPLCFGKRQNPDTGGRAPACRAFLAPAAGTTETPGPGSPGGGRAKSGQPLRS
AGENARVRGPLPSFHHRAPRQGPGRERERWHGDGEGPGGAWGTLEGQDRGQSLKHRQETAVPRRQPLHEGLLVGRAVDFEEEFVILLPLL
QLPLQLAPVADQVEREAEAQQAEKEQPHVHPQRVSLERTHHGQKQRLLQKGEERADQRLQSREAAELGGGVHGSVQAPDSGVDESSHDCV
QDEGEDLERQVGNEAGHPKAHEQQVGEGEGPHGISDLLDLPVPLLLFLLALVGVFLLGLLGGVFTLLQPPVHDVANDGGRQQAQQLEHAE
DGGVEANCGGSCLLVAADQELEDVVHSPHVEDEPQLRDAHGDQAEQQDGAEHAVHEGGGHCGIRLALHLQVDGGQAQLVALLQRHLLLGT
PHGAAHTQAPAHRGHLLVELLPCDLVVKAQPAELDLHRVVHVLRPREGLKGPVKEAVEENQPGAAGPDHEDDDEGDTSIIDELDSWKGDC

--------------------------------------------------------------

>100157_100157_23_YWHAE-SLC43A2_YWHAE_chr17_1303341_ENST00000264335_SLC43A2_chr17_1496573_ENST00000412517_length(amino acids)=447AA_BP=1
MEGQDRGQSLKHRQETAVPRRQPLHEGLLVGRAVDFEEEFVILLPLLQLPLQLAPVADQVEREAEAQQAEKEQPHVHPQRVSLERTHHGQ
KQRLLQKGEERADQRLQSREAAELGGGVHGSVQAPDSGVDESSHDCVQDEGEDLERQVGNEAGHPKAHEQQVGEGEGPHGISDLLDLPVP
LLLFLLALVGVFLLGLLGGVFTLLQPPVHDVANDGGRQQAQQLEHAEDGGVEANCLLVAADQELEDVVHSPHVEDEPQLRDAHGDQAEQQ
DGAEHAVHEGGGHCGIRLALHLQVDGGQAQLVALLQRHLLLGTPHGAAHTQAPAHRGHLLVELLPCDLVVKAQPAELDLHRVVHVLRPRE

--------------------------------------------------------------

>100157_100157_24_YWHAE-SLC43A2_YWHAE_chr17_1303341_ENST00000264335_SLC43A2_chr17_1496573_ENST00000571650_length(amino acids)=584AA_BP=1
MAGEGVGARRGRDSASLCPQAGTAVGMQPRGRWQAGDGSPLCFGKRQNPDTGGRAPACRAFLAPAAGTTETPGPGSPGGGRAKSGQPLRS
AGENARVRGPLPSFHHRAPRQGPGRERERWHGDGEGPGGAWGTLEGQDRGQSLKHRQETAVPRRQPLHEGLLVGRAVDFEEEFVILLPLL
QLPLQLAPVADQVEREAEAQQAEKEQPHVHPQRVSLERTHHGQKQRLLQKGEERADQRLQSREAAELGGGVHGSVQAPDSGVDESSHDCV
QDEGEDLERQVGNEAGHPKAHEQQVGEGEGPHGISDLLDLPVPLLLFLLALVGVFLLGLLGGVFTLLQPPVHDVANDGGRQQAQQLEHAE
DGGVEANRGHHCLLVAADQELEDVVHSPHVEDEPQLRDAHGDQAEQQDGAEHAVHEGGGHCGIRLALHLQVDGGQAQLVALLQRHLLLGT
PHGAAHTQAPAHRGHLLVELLPCDLVVKAQPAELDLHRVVHVLRPREGLKGPVKEAVEENQPGAAGPDHEDDDEGDTSIIDELDSWKGDC

--------------------------------------------------------------

>100157_100157_25_YWHAE-SLC43A2_YWHAE_chr17_1303341_ENST00000573026_SLC43A2_chr17_1496573_ENST00000301335_length(amino acids)=580AA_BP=1
MAGEGVGARRGRDSASLCPQAGTAVGMQPRGRWQAGDGSPLCFGKRQNPDTGGRAPACRAFLAPAAGTTETPGPGSPGGGRAKSGQPLRS
AGENARVRGPLPSFHHRAPRQGPGRERERWHGDGEGPGGAWGTLEGQDRGQSLKHRQETAVPRRQPLHEGLLVGRAVDFEEEFVILLPLL
QLPLQLAPVADQVEREAEAQQAEKEQPHVHPQRVSLERTHHGQKQRLLQKGEERADQRLQSREAAELGGGVHGSVQAPDSGVDESSHDCV
QDEGEDLERQVGNEAGHPKAHEQQVGEGEGPHGISDLLDLPVPLLLFLLALVGVFLLGLLGGVFTLLQPPVHDVANDGGRQQAQQLEHAE
DGGVEANCLLVAADQELEDVVHSPHVEDEPQLRDAHGDQAEQQDGAEHAVHEGGGHCGIRLALHLQVDGGQAQLVALLQRHLLLGTPHGA
AHTQAPAHRGHLLVELLPCDLVVKAQPAELDLHRVVHVLRPREGLKGPVKEAVEENQPGAAGPDHEDDDEGDTSIIDELDSWKGDCRGGV

--------------------------------------------------------------

>100157_100157_26_YWHAE-SLC43A2_YWHAE_chr17_1303341_ENST00000573026_SLC43A2_chr17_1496573_ENST00000382147_length(amino acids)=584AA_BP=1
MAGEGVGARRGRDSASLCPQAGTAVGMQPRGRWQAGDGSPLCFGKRQNPDTGGRAPACRAFLAPAAGTTETPGPGSPGGGRAKSGQPLRS
AGENARVRGPLPSFHHRAPRQGPGRERERWHGDGEGPGGAWGTLEGQDRGQSLKHRQETAVPRRQPLHEGLLVGRAVDFEEEFVILLPLL
QLPLQLAPVADQVEREAEAQQAEKEQPHVHPQRVSLERTHHGQKQRLLQKGEERADQRLQSREAAELGGGVHGSVQAPDSGVDESSHDCV
QDEGEDLERQVGNEAGHPKAHEQQVGEGEGPHGISDLLDLPVPLLLFLLALVGVFLLGLLGGVFTLLQPPVHDVANDGGRQQAQQLEHAE
DGGVEANCGGSCLLVAADQELEDVVHSPHVEDEPQLRDAHGDQAEQQDGAEHAVHEGGGHCGIRLALHLQVDGGQAQLVALLQRHLLLGT
PHGAAHTQAPAHRGHLLVELLPCDLVVKAQPAELDLHRVVHVLRPREGLKGPVKEAVEENQPGAAGPDHEDDDEGDTSIIDELDSWKGDC

--------------------------------------------------------------

>100157_100157_27_YWHAE-SLC43A2_YWHAE_chr17_1303341_ENST00000573026_SLC43A2_chr17_1496573_ENST00000412517_length(amino acids)=447AA_BP=1
MEGQDRGQSLKHRQETAVPRRQPLHEGLLVGRAVDFEEEFVILLPLLQLPLQLAPVADQVEREAEAQQAEKEQPHVHPQRVSLERTHHGQ
KQRLLQKGEERADQRLQSREAAELGGGVHGSVQAPDSGVDESSHDCVQDEGEDLERQVGNEAGHPKAHEQQVGEGEGPHGISDLLDLPVP
LLLFLLALVGVFLLGLLGGVFTLLQPPVHDVANDGGRQQAQQLEHAEDGGVEANCLLVAADQELEDVVHSPHVEDEPQLRDAHGDQAEQQ
DGAEHAVHEGGGHCGIRLALHLQVDGGQAQLVALLQRHLLLGTPHGAAHTQAPAHRGHLLVELLPCDLVVKAQPAELDLHRVVHVLRPRE

--------------------------------------------------------------

>100157_100157_28_YWHAE-SLC43A2_YWHAE_chr17_1303341_ENST00000573026_SLC43A2_chr17_1496573_ENST00000571650_length(amino acids)=584AA_BP=1
MAGEGVGARRGRDSASLCPQAGTAVGMQPRGRWQAGDGSPLCFGKRQNPDTGGRAPACRAFLAPAAGTTETPGPGSPGGGRAKSGQPLRS
AGENARVRGPLPSFHHRAPRQGPGRERERWHGDGEGPGGAWGTLEGQDRGQSLKHRQETAVPRRQPLHEGLLVGRAVDFEEEFVILLPLL
QLPLQLAPVADQVEREAEAQQAEKEQPHVHPQRVSLERTHHGQKQRLLQKGEERADQRLQSREAAELGGGVHGSVQAPDSGVDESSHDCV
QDEGEDLERQVGNEAGHPKAHEQQVGEGEGPHGISDLLDLPVPLLLFLLALVGVFLLGLLGGVFTLLQPPVHDVANDGGRQQAQQLEHAE
DGGVEANRGHHCLLVAADQELEDVVHSPHVEDEPQLRDAHGDQAEQQDGAEHAVHEGGGHCGIRLALHLQVDGGQAQLVALLQRHLLLGT
PHGAAHTQAPAHRGHLLVELLPCDLVVKAQPAELDLHRVVHVLRPREGLKGPVKEAVEENQPGAAGPDHEDDDEGDTSIIDELDSWKGDC

--------------------------------------------------------------

>100157_100157_29_YWHAE-SLC43A2_YWHAE_chr17_1303341_ENST00000575977_SLC43A2_chr17_1496573_ENST00000301335_length(amino acids)=580AA_BP=1
MAGEGVGARRGRDSASLCPQAGTAVGMQPRGRWQAGDGSPLCFGKRQNPDTGGRAPACRAFLAPAAGTTETPGPGSPGGGRAKSGQPLRS
AGENARVRGPLPSFHHRAPRQGPGRERERWHGDGEGPGGAWGTLEGQDRGQSLKHRQETAVPRRQPLHEGLLVGRAVDFEEEFVILLPLL
QLPLQLAPVADQVEREAEAQQAEKEQPHVHPQRVSLERTHHGQKQRLLQKGEERADQRLQSREAAELGGGVHGSVQAPDSGVDESSHDCV
QDEGEDLERQVGNEAGHPKAHEQQVGEGEGPHGISDLLDLPVPLLLFLLALVGVFLLGLLGGVFTLLQPPVHDVANDGGRQQAQQLEHAE
DGGVEANCLLVAADQELEDVVHSPHVEDEPQLRDAHGDQAEQQDGAEHAVHEGGGHCGIRLALHLQVDGGQAQLVALLQRHLLLGTPHGA
AHTQAPAHRGHLLVELLPCDLVVKAQPAELDLHRVVHVLRPREGLKGPVKEAVEENQPGAAGPDHEDDDEGDTSIIDELDSWKGDCRGGV

--------------------------------------------------------------

>100157_100157_30_YWHAE-SLC43A2_YWHAE_chr17_1303341_ENST00000575977_SLC43A2_chr17_1496573_ENST00000382147_length(amino acids)=584AA_BP=1
MAGEGVGARRGRDSASLCPQAGTAVGMQPRGRWQAGDGSPLCFGKRQNPDTGGRAPACRAFLAPAAGTTETPGPGSPGGGRAKSGQPLRS
AGENARVRGPLPSFHHRAPRQGPGRERERWHGDGEGPGGAWGTLEGQDRGQSLKHRQETAVPRRQPLHEGLLVGRAVDFEEEFVILLPLL
QLPLQLAPVADQVEREAEAQQAEKEQPHVHPQRVSLERTHHGQKQRLLQKGEERADQRLQSREAAELGGGVHGSVQAPDSGVDESSHDCV
QDEGEDLERQVGNEAGHPKAHEQQVGEGEGPHGISDLLDLPVPLLLFLLALVGVFLLGLLGGVFTLLQPPVHDVANDGGRQQAQQLEHAE
DGGVEANCGGSCLLVAADQELEDVVHSPHVEDEPQLRDAHGDQAEQQDGAEHAVHEGGGHCGIRLALHLQVDGGQAQLVALLQRHLLLGT
PHGAAHTQAPAHRGHLLVELLPCDLVVKAQPAELDLHRVVHVLRPREGLKGPVKEAVEENQPGAAGPDHEDDDEGDTSIIDELDSWKGDC

--------------------------------------------------------------

>100157_100157_31_YWHAE-SLC43A2_YWHAE_chr17_1303341_ENST00000575977_SLC43A2_chr17_1496573_ENST00000412517_length(amino acids)=447AA_BP=1
MEGQDRGQSLKHRQETAVPRRQPLHEGLLVGRAVDFEEEFVILLPLLQLPLQLAPVADQVEREAEAQQAEKEQPHVHPQRVSLERTHHGQ
KQRLLQKGEERADQRLQSREAAELGGGVHGSVQAPDSGVDESSHDCVQDEGEDLERQVGNEAGHPKAHEQQVGEGEGPHGISDLLDLPVP
LLLFLLALVGVFLLGLLGGVFTLLQPPVHDVANDGGRQQAQQLEHAEDGGVEANCLLVAADQELEDVVHSPHVEDEPQLRDAHGDQAEQQ
DGAEHAVHEGGGHCGIRLALHLQVDGGQAQLVALLQRHLLLGTPHGAAHTQAPAHRGHLLVELLPCDLVVKAQPAELDLHRVVHVLRPRE

--------------------------------------------------------------

>100157_100157_32_YWHAE-SLC43A2_YWHAE_chr17_1303341_ENST00000575977_SLC43A2_chr17_1496573_ENST00000571650_length(amino acids)=584AA_BP=1
MAGEGVGARRGRDSASLCPQAGTAVGMQPRGRWQAGDGSPLCFGKRQNPDTGGRAPACRAFLAPAAGTTETPGPGSPGGGRAKSGQPLRS
AGENARVRGPLPSFHHRAPRQGPGRERERWHGDGEGPGGAWGTLEGQDRGQSLKHRQETAVPRRQPLHEGLLVGRAVDFEEEFVILLPLL
QLPLQLAPVADQVEREAEAQQAEKEQPHVHPQRVSLERTHHGQKQRLLQKGEERADQRLQSREAAELGGGVHGSVQAPDSGVDESSHDCV
QDEGEDLERQVGNEAGHPKAHEQQVGEGEGPHGISDLLDLPVPLLLFLLALVGVFLLGLLGGVFTLLQPPVHDVANDGGRQQAQQLEHAE
DGGVEANRGHHCLLVAADQELEDVVHSPHVEDEPQLRDAHGDQAEQQDGAEHAVHEGGGHCGIRLALHLQVDGGQAQLVALLQRHLLLGT
PHGAAHTQAPAHRGHLLVELLPCDLVVKAQPAELDLHRVVHVLRPREGLKGPVKEAVEENQPGAAGPDHEDDDEGDTSIIDELDSWKGDC

--------------------------------------------------------------

Top

Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:1257505/chr17:1489345)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
YWHAE

P62258

.
FUNCTION: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner (By similarity). Positively regulates phosphorylated protein HSF1 nuclear export to the cytoplasm (PubMed:12917326). {ECO:0000250|UniProtKB:P62261, ECO:0000269|PubMed:12917326}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSLC43A2chr17:1257504chr17:1489345ENST00000301335814409_413359.3333333333333570.0Compositional biasNote=Poly-Lys
TgeneSLC43A2chr17:1257504chr17:1489345ENST00000571650915409_413363.3333333333333574.0Compositional biasNote=Poly-Lys
TgeneSLC43A2chr17:1257505chr17:1489345ENST00000301335814409_413359.3333333333333570.0Compositional biasNote=Poly-Lys
TgeneSLC43A2chr17:1257505chr17:1489345ENST00000571650915409_413363.3333333333333574.0Compositional biasNote=Poly-Lys
TgeneSLC43A2chr17:1303340chr17:1496573ENST00000301335414409_413167.0570.0Compositional biasNote=Poly-Lys
TgeneSLC43A2chr17:1303340chr17:1496573ENST00000571650415409_413167.0574.0Compositional biasNote=Poly-Lys
TgeneSLC43A2chr17:1303341chr17:1496573ENST00000301335414409_413167.0570.0Compositional biasNote=Poly-Lys
TgeneSLC43A2chr17:1303341chr17:1496573ENST00000571650415409_413167.0574.0Compositional biasNote=Poly-Lys
TgeneSLC43A2chr17:1257504chr17:1489345ENST00000301335814365_385359.3333333333333570.0TransmembraneHelical
TgeneSLC43A2chr17:1257504chr17:1489345ENST00000301335814435_455359.3333333333333570.0TransmembraneHelical
TgeneSLC43A2chr17:1257504chr17:1489345ENST00000301335814462_482359.3333333333333570.0TransmembraneHelical
TgeneSLC43A2chr17:1257504chr17:1489345ENST00000301335814490_510359.3333333333333570.0TransmembraneHelical
TgeneSLC43A2chr17:1257504chr17:1489345ENST00000301335814516_536359.3333333333333570.0TransmembraneHelical
TgeneSLC43A2chr17:1257504chr17:1489345ENST00000571650915365_385363.3333333333333574.0TransmembraneHelical
TgeneSLC43A2chr17:1257504chr17:1489345ENST00000571650915435_455363.3333333333333574.0TransmembraneHelical
TgeneSLC43A2chr17:1257504chr17:1489345ENST00000571650915462_482363.3333333333333574.0TransmembraneHelical
TgeneSLC43A2chr17:1257504chr17:1489345ENST00000571650915490_510363.3333333333333574.0TransmembraneHelical
TgeneSLC43A2chr17:1257504chr17:1489345ENST00000571650915516_536363.3333333333333574.0TransmembraneHelical
TgeneSLC43A2chr17:1257505chr17:1489345ENST00000301335814365_385359.3333333333333570.0TransmembraneHelical
TgeneSLC43A2chr17:1257505chr17:1489345ENST00000301335814435_455359.3333333333333570.0TransmembraneHelical
TgeneSLC43A2chr17:1257505chr17:1489345ENST00000301335814462_482359.3333333333333570.0TransmembraneHelical
TgeneSLC43A2chr17:1257505chr17:1489345ENST00000301335814490_510359.3333333333333570.0TransmembraneHelical
TgeneSLC43A2chr17:1257505chr17:1489345ENST00000301335814516_536359.3333333333333570.0TransmembraneHelical
TgeneSLC43A2chr17:1257505chr17:1489345ENST00000571650915365_385363.3333333333333574.0TransmembraneHelical
TgeneSLC43A2chr17:1257505chr17:1489345ENST00000571650915435_455363.3333333333333574.0TransmembraneHelical
TgeneSLC43A2chr17:1257505chr17:1489345ENST00000571650915462_482363.3333333333333574.0TransmembraneHelical
TgeneSLC43A2chr17:1257505chr17:1489345ENST00000571650915490_510363.3333333333333574.0TransmembraneHelical
TgeneSLC43A2chr17:1257505chr17:1489345ENST00000571650915516_536363.3333333333333574.0TransmembraneHelical
TgeneSLC43A2chr17:1303340chr17:1496573ENST00000301335414177_197167.0570.0TransmembraneHelical
TgeneSLC43A2chr17:1303340chr17:1496573ENST00000301335414203_223167.0570.0TransmembraneHelical
TgeneSLC43A2chr17:1303340chr17:1496573ENST00000301335414323_345167.0570.0TransmembraneHelical
TgeneSLC43A2chr17:1303340chr17:1496573ENST00000301335414365_385167.0570.0TransmembraneHelical
TgeneSLC43A2chr17:1303340chr17:1496573ENST00000301335414435_455167.0570.0TransmembraneHelical
TgeneSLC43A2chr17:1303340chr17:1496573ENST00000301335414462_482167.0570.0TransmembraneHelical
TgeneSLC43A2chr17:1303340chr17:1496573ENST00000301335414490_510167.0570.0TransmembraneHelical
TgeneSLC43A2chr17:1303340chr17:1496573ENST00000301335414516_536167.0570.0TransmembraneHelical
TgeneSLC43A2chr17:1303340chr17:1496573ENST00000571650415177_197167.0574.0TransmembraneHelical
TgeneSLC43A2chr17:1303340chr17:1496573ENST00000571650415203_223167.0574.0TransmembraneHelical
TgeneSLC43A2chr17:1303340chr17:1496573ENST00000571650415323_345167.0574.0TransmembraneHelical
TgeneSLC43A2chr17:1303340chr17:1496573ENST00000571650415365_385167.0574.0TransmembraneHelical
TgeneSLC43A2chr17:1303340chr17:1496573ENST00000571650415435_455167.0574.0TransmembraneHelical
TgeneSLC43A2chr17:1303340chr17:1496573ENST00000571650415462_482167.0574.0TransmembraneHelical
TgeneSLC43A2chr17:1303340chr17:1496573ENST00000571650415490_510167.0574.0TransmembraneHelical
TgeneSLC43A2chr17:1303340chr17:1496573ENST00000571650415516_536167.0574.0TransmembraneHelical
TgeneSLC43A2chr17:1303341chr17:1496573ENST00000301335414177_197167.0570.0TransmembraneHelical
TgeneSLC43A2chr17:1303341chr17:1496573ENST00000301335414203_223167.0570.0TransmembraneHelical
TgeneSLC43A2chr17:1303341chr17:1496573ENST00000301335414323_345167.0570.0TransmembraneHelical
TgeneSLC43A2chr17:1303341chr17:1496573ENST00000301335414365_385167.0570.0TransmembraneHelical
TgeneSLC43A2chr17:1303341chr17:1496573ENST00000301335414435_455167.0570.0TransmembraneHelical
TgeneSLC43A2chr17:1303341chr17:1496573ENST00000301335414462_482167.0570.0TransmembraneHelical
TgeneSLC43A2chr17:1303341chr17:1496573ENST00000301335414490_510167.0570.0TransmembraneHelical
TgeneSLC43A2chr17:1303341chr17:1496573ENST00000301335414516_536167.0570.0TransmembraneHelical
TgeneSLC43A2chr17:1303341chr17:1496573ENST00000571650415177_197167.0574.0TransmembraneHelical
TgeneSLC43A2chr17:1303341chr17:1496573ENST00000571650415203_223167.0574.0TransmembraneHelical
TgeneSLC43A2chr17:1303341chr17:1496573ENST00000571650415323_345167.0574.0TransmembraneHelical
TgeneSLC43A2chr17:1303341chr17:1496573ENST00000571650415365_385167.0574.0TransmembraneHelical
TgeneSLC43A2chr17:1303341chr17:1496573ENST00000571650415435_455167.0574.0TransmembraneHelical
TgeneSLC43A2chr17:1303341chr17:1496573ENST00000571650415462_482167.0574.0TransmembraneHelical
TgeneSLC43A2chr17:1303341chr17:1496573ENST00000571650415490_510167.0574.0TransmembraneHelical
TgeneSLC43A2chr17:1303341chr17:1496573ENST00000571650415516_536167.0574.0TransmembraneHelical

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSLC43A2chr17:1257504chr17:1489345ENST00000301335814120_140359.3333333333333570.0TransmembraneHelical
TgeneSLC43A2chr17:1257504chr17:1489345ENST00000301335814143_163359.3333333333333570.0TransmembraneHelical
TgeneSLC43A2chr17:1257504chr17:1489345ENST00000301335814177_197359.3333333333333570.0TransmembraneHelical
TgeneSLC43A2chr17:1257504chr17:1489345ENST00000301335814203_223359.3333333333333570.0TransmembraneHelical
TgeneSLC43A2chr17:1257504chr17:1489345ENST0000030133581420_40359.3333333333333570.0TransmembraneHelical
TgeneSLC43A2chr17:1257504chr17:1489345ENST00000301335814323_345359.3333333333333570.0TransmembraneHelical
TgeneSLC43A2chr17:1257504chr17:1489345ENST0000030133581490_110359.3333333333333570.0TransmembraneHelical
TgeneSLC43A2chr17:1257504chr17:1489345ENST00000571650915120_140363.3333333333333574.0TransmembraneHelical
TgeneSLC43A2chr17:1257504chr17:1489345ENST00000571650915143_163363.3333333333333574.0TransmembraneHelical
TgeneSLC43A2chr17:1257504chr17:1489345ENST00000571650915177_197363.3333333333333574.0TransmembraneHelical
TgeneSLC43A2chr17:1257504chr17:1489345ENST00000571650915203_223363.3333333333333574.0TransmembraneHelical
TgeneSLC43A2chr17:1257504chr17:1489345ENST0000057165091520_40363.3333333333333574.0TransmembraneHelical
TgeneSLC43A2chr17:1257504chr17:1489345ENST00000571650915323_345363.3333333333333574.0TransmembraneHelical
TgeneSLC43A2chr17:1257504chr17:1489345ENST0000057165091590_110363.3333333333333574.0TransmembraneHelical
TgeneSLC43A2chr17:1257505chr17:1489345ENST00000301335814120_140359.3333333333333570.0TransmembraneHelical
TgeneSLC43A2chr17:1257505chr17:1489345ENST00000301335814143_163359.3333333333333570.0TransmembraneHelical
TgeneSLC43A2chr17:1257505chr17:1489345ENST00000301335814177_197359.3333333333333570.0TransmembraneHelical
TgeneSLC43A2chr17:1257505chr17:1489345ENST00000301335814203_223359.3333333333333570.0TransmembraneHelical
TgeneSLC43A2chr17:1257505chr17:1489345ENST0000030133581420_40359.3333333333333570.0TransmembraneHelical
TgeneSLC43A2chr17:1257505chr17:1489345ENST00000301335814323_345359.3333333333333570.0TransmembraneHelical
TgeneSLC43A2chr17:1257505chr17:1489345ENST0000030133581490_110359.3333333333333570.0TransmembraneHelical
TgeneSLC43A2chr17:1257505chr17:1489345ENST00000571650915120_140363.3333333333333574.0TransmembraneHelical
TgeneSLC43A2chr17:1257505chr17:1489345ENST00000571650915143_163363.3333333333333574.0TransmembraneHelical
TgeneSLC43A2chr17:1257505chr17:1489345ENST00000571650915177_197363.3333333333333574.0TransmembraneHelical
TgeneSLC43A2chr17:1257505chr17:1489345ENST00000571650915203_223363.3333333333333574.0TransmembraneHelical
TgeneSLC43A2chr17:1257505chr17:1489345ENST0000057165091520_40363.3333333333333574.0TransmembraneHelical
TgeneSLC43A2chr17:1257505chr17:1489345ENST00000571650915323_345363.3333333333333574.0TransmembraneHelical
TgeneSLC43A2chr17:1257505chr17:1489345ENST0000057165091590_110363.3333333333333574.0TransmembraneHelical
TgeneSLC43A2chr17:1303340chr17:1496573ENST00000301335414120_140167.0570.0TransmembraneHelical
TgeneSLC43A2chr17:1303340chr17:1496573ENST00000301335414143_163167.0570.0TransmembraneHelical
TgeneSLC43A2chr17:1303340chr17:1496573ENST0000030133541420_40167.0570.0TransmembraneHelical
TgeneSLC43A2chr17:1303340chr17:1496573ENST0000030133541490_110167.0570.0TransmembraneHelical
TgeneSLC43A2chr17:1303340chr17:1496573ENST00000571650415120_140167.0574.0TransmembraneHelical
TgeneSLC43A2chr17:1303340chr17:1496573ENST00000571650415143_163167.0574.0TransmembraneHelical
TgeneSLC43A2chr17:1303340chr17:1496573ENST0000057165041520_40167.0574.0TransmembraneHelical
TgeneSLC43A2chr17:1303340chr17:1496573ENST0000057165041590_110167.0574.0TransmembraneHelical
TgeneSLC43A2chr17:1303341chr17:1496573ENST00000301335414120_140167.0570.0TransmembraneHelical
TgeneSLC43A2chr17:1303341chr17:1496573ENST00000301335414143_163167.0570.0TransmembraneHelical
TgeneSLC43A2chr17:1303341chr17:1496573ENST0000030133541420_40167.0570.0TransmembraneHelical
TgeneSLC43A2chr17:1303341chr17:1496573ENST0000030133541490_110167.0570.0TransmembraneHelical
TgeneSLC43A2chr17:1303341chr17:1496573ENST00000571650415120_140167.0574.0TransmembraneHelical
TgeneSLC43A2chr17:1303341chr17:1496573ENST00000571650415143_163167.0574.0TransmembraneHelical
TgeneSLC43A2chr17:1303341chr17:1496573ENST0000057165041520_40167.0574.0TransmembraneHelical
TgeneSLC43A2chr17:1303341chr17:1496573ENST0000057165041590_110167.0574.0TransmembraneHelical


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors
YWHAEIGF1R, GPRIN2, SORBS2, GRAP2, MAPK7, NDEL1, HDAC4, HDAC5, REM1, BAD, MAP3K10, CDC25C, MAP3K3, MAP3K1, MAP3K2, IRS1, NGFRAP1, SYN2, KCNH2, TNFAIP3, RAF1, CDC25B, TOP2A, TGFB1, CDC25A, Usp8, USP43, POLR3H, HDAC7, MDM4, FOXO3, HIVEP2, LRMP, COX2, MYH10, PNLIP, SSFA2, YWHAB, YWHAZ, YWHAG, ARAF, YWHAH, HDAC9, KIAA0232, TLK1, CHAF1A, CAP2, YWHAQ, RAP1GAP2, SH3BP4, WWTR1, FAM13B, MSL2, ZNF839, RASAL3, WNK1, ENKD1, TBC1D3F, CGNL1, CEP95, ANKHD1-EIF4EBP3, ING1, SRRM2, FAN1, EMD, SAMSN1, EXO1, H2AFX, MYC, PRKAA1, PARD6G, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, DISC1, UBE3A, GAPDH, KAT8, HIST1H3A, HIST1H4A, TCEB3, BRD4, CALM1, FBXO4, CDKN1B, TRAT1, RARRES3, ARRB1, ARRB2, CBL, ACD, POT1, CUL3, CDK2, CUL1, DCUN1D1, NEDD8, PTPN14, MARK3, MARK2, MEX3B, LRRK2, AKT1, ACTA2, CBX3, HNF1A, HSP90AB1, NPM1, ATP5B, ATP5A1, STOML2, CLNS1A, IPO8, KPNB1, RPLP0, RPL6, RPL4, RPS3, RPS8, DNAJA1, EIF4B, EIF3E, EEF1G, EEF1A2, HNRNPA2B1, ILF2, RUVBL2, RCN2, TUBB, TUBB4B, TUBB2B, PRPSAP1, TUBA3E, DDX21, ADH1B, ADH4, AGXT, HIST2H4B, HNRNPA3, HNRNPC, RBMY1A1, SF3B1, PCBP1, RBM10, MAP3K7, TBK1, PPM1B, SPIN1, CDC37, PHB, PRPSAP2, PRPS1, QPCTL, TMPO, C11orf84, HDX, CFAP43, VCP, ATXN1, FN1, VCAM1, BRAF, MAP2K1, PARD3, KIF5B, KLC2, LMO7, TBC1D4, HSPA1A, KLC3, KLC4, KLC1, CLASP2, LIMA1, TSC2, CLASP1, HSPA8, PAK4, RAB11FIP2, MAST3, TBC1D1, KIF1C, OSBPL3, TIAM1, ABLIM1, LARP1, BAIAP2, IRS2, SHROOM2, LSR, KIF1B, RAB11FIP1, MLLT4, MAST2, PFKFB2, CDK18, PKP2, DENND4A, TP53BP2, CGN, ZFP36L2, TUBA1A, KSR1, RABEP1, EIF4E2, CSNK1A1, PDZD11, PRKCI, DCAF7, NADK, USP8, C1QBP, TSC1, REEP1, KIF23, SLC25A6, SRGAP2, FAM53C, TRIP11, BCAR1, CRTC1, RASSF8, CEP250, VAMP8, GRB2, TRIM32, NOS2, IL7R, UBL4A, ITGA4, gag-pol, CBX4, ABL1, MST1R, PAN2, RAD52, BAG3, UL46, GSTA1, FTH1, Wwtr1, Yap1, CDK11B, SRSF1, SRSF6, SRSF4, NOLC1, TRA2B, PLEKHO2, HMHA1, SRSF7, NCBP1, DOK3, VASP, KIAA0930, GAB2, KIAA0226, PIK3R4, SGK223, RCHY1, IGHG1, UVRAG, SRSF2, FBXO6, RASSF2, SAV1, YAP1, PARK2, PAFAH1B2, PPP1R2, PROSC, RAP1GDS1, TMOD3, TNFAIP8, TUBB2A, UBXN1, VCL, XPO1, ALDH7A1, ASNS, ATIC, CAPN2, CAPNS1, EIF5, FERMT2, G6PD, GSS, ISOC1, MCTS1, STK26, OGFOD1, PAK2, PDHB, PDIA4, PTMA, SCPEP1, TBCB, TWF2, UBE2R2, IRS4, SIK3, SIK2, CEP57, TP53, GRB10, DTL, HUWE1, FBXW11, Mdm4, CUL7, OBSL1, CCDC8, MAST1, CDK16, TNK1, BTRC, NKD2, DMTN, TEX33, Numb, EPB41L3, WWC1, HNRNPA1, HSPB1, UNK, ACAT2, CALR, CENPE, MACF1, MAPK14, MCFD2, POLR2D, PSMB2, SHMT2, SNRPD1, ACTR6, HNRNPL, NPM3, PGK1, PSMC1, ZPR1, NTRK1, LCA5, CENPJ, PRICKLE3, MYH11, TSNAX, CCDC88A, CRY1, CRY2, MCM2, Ksr1, CDC5L, ERRFI1, U2AF2, PRDX6, NFATC2, SNF8, ANKZF1, SMAGP, TCEANC, LCP2, METAP2, MAGEB4, CHST11, ZC3HC1, MCM10, DDX54, C8orf59, NAF1, FGF12, GSTM3, STAC, FAM64A, ATP6V0B, FLJ25758, CDC73, WWP2, CDH1, CEP131, PCM1, PPM1H, PTPN3, SSH1, TENC1, SMTNL2, PLEKHG5, SAMD4A, SPATA13, RIN1, TFEB, TESPA1, SAMD4B, FAM163A, CRTC2, FAM189A2, PAK6, RBM3, RAB3IP, CBY1, CEP170, INPP5E, SLC9A1, CYLD, COX15, DLD, DLST, DNM1L, SDHA, SOAT1, VDAC1, TRIM25, BRCA1, BRD1, BRMS1, YLR177W, ACM1, IFNAR1, CFTR, TARDBP, ZNF598, CTNNB1, MEX3C, EGLN3, RIPK4, PTPN4, API5, KRAS, PPP6C, COPE, GRHPR, JUP, PPIE, YAF2, PARD3B, RPA2, NIN, AKAP9, CASK, PRC1, RBM14, UBE2M, RAD18, EFTUD2, AAR2, PIH1D1, TNIP2, RNF31, HAVCR1, BPLF1, ESR2, HEXIM1, MEPCE, PPT1, AGR2, EZH2, RECQL4, KANK1, STUB1, BAP1, PIK3R1, GPC1, Prkaa1, Nav2, KIAA1429, RC3H1, RC3H2, ATG16L1, ACTC1, FAF1, CLIC4, FHL1, FHL2, FHL3, LMO1, LMO2, LMO3, TET2, KCTD15, GBF1, AGRN, BMH1, BMH2, ATXN3, HIBADH, DIABLO, NDUFAB1, ALDH1B1, ALDH2, COQ9, FH, HEXA, HSP90AA1, LDHB, MMP20, RAD23A, TIMM44, UBA1, VBP1, AARS2, ECH1, GRPEL1, IARS2, PAFAH2, PFDN4, SSBP1, DYRK1A, MAPT, CD74, SLC15A3, GEM, DUSP16, MTMR4, PTPDC1, ITFG1, BIRC3, NFX1, nsp7ab, ORF3a, CCDC125, PLEKHA4, PINK1, FANCD2, NGB, ZC3H18, CSK, PDPK1, PRKCE, PRKD1, SHC1, SHOC2, SFN, PHACTR4, MAP3K5, CHAF1B, CAMSAP3, LRCH1, SH2B3, CDK12, TANC2, EPN3, PANK2, MAP3K15, CEP89, FRMD6, THAP11, TTC17, CCNY, ARHGEF19, FAM122B, DAB2IP, FAM110C, LPIN1, PRR5, DNMT1, CDK11A, SRSF10, TBC1D7, NEDD4L, FAM117B, KANK2, DENND4C, RGS12, YWHAE, EMC4, ERC2, APPL2, ANKRD55, ESR1, SNAPIN, EDC3, NEK4, CHMP4C, CCR9, CYSLTR2, RXFP3, KIF14, RMDN3, HNRNPH1, INS, Rnf183, NUPR1, CIC, CCAR2, Apc2, RBM39, LGALS9, ACTN4, BTF3, CAD, CALD1, CDKN2A, COPA, DDB1, DDX6, DHX9, EIF2B1, GOLGA3, HDAC1, JAK1, LTBP1, PPP1R12A, NONO, PA2G4, PAWR, PRPS2, RBBP4, ROCK1, SMARCC2, TRIM21, TAF4, EIF3A, PABPC4, LRRFIP2, MTA2, VPRBP, EIF4A3, MATR3, HDAC6, SAE1, G3BP1, SMC2, IVNS1ABP, SF3B2, FASTKD2, NT5C2, STK38L, MGA, UBR2, CAND1, EFHD2, SHCBP1, SFPQ, TAB3, TAB1, ACAP2, INSIG1, NEDD4, SOD1, IL1B, UFL1, DDRGK1, KRT8, VAPA, FZR1, PAGE4, NUDCD2, LNP1, SNX33, FAM53B, SYNGAP1, CDR2L, GUCA1B, KIAA1211, ARHGEF4, FAM124A, EPB41L1, AFAP1L1, MIIP, PLEKHA3, GAREM, CD28, GPSM3, SIPA1L3, PDE7B, C19orf26, C6orf222, PSD4, MACC1, ZNF395, FAM86C1, SH2D3A, NCKIPSD, KSR2, SPRTN, TRIM26, FBXW7, FGD5, CCNF, HECTD1, NBR1, SQSTM1, MAP1LC3B, SLFN11, RIPK2, PER2,


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
YWHAEall structure
SLC43A2


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to YWHAE-SLC43A2


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to YWHAE-SLC43A2


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneYWHAEC0036341Schizophrenia4PSYGENET
HgeneYWHAEC0005586Bipolar Disorder2PSYGENET
HgeneYWHAEC0206630Endometrial Stromal Sarcoma2ORPHANET
HgeneYWHAEC0027627Neoplasm Metastasis1CTD_human
HgeneYWHAEC0265219Miller Dieker syndrome1ORPHANET
HgeneYWHAEC0334488Clear cell sarcoma of kidney1ORPHANET
HgeneYWHAEC2750748Chromosome 17p13.3 Duplication Syndrome1ORPHANET
HgeneYWHAEC4707092Distal 17p13.3 microdeletion syndrome1ORPHANET