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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Potential Active Site Information
	Potentially Interacting Small Molecules through Virtual Screening
	Biochemical Features of Small Molecules with ADME
	Drug Toxicity Information
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:ZC3H7B-BCOR

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: ZC3H7B-BCOR
	FusionPDB ID: 100589
	FusionGDB2.0 ID: 100589
		Hgene	Tgene
	Gene symbol	ZC3H7B	BCOR
	Gene ID	23264	54880
	Gene name	zinc finger CCCH-type containing 7B	BCL6 corepressor
	Synonyms	ROXAN1\|RoXaN	ANOP2\|MAA2\|MCOPS2
	Cytomap	22q13.2	Xp11.4
	Type of gene	protein-coding	protein-coding
	Description	zinc finger CCCH domain-containing protein 7BRotavirus 'X' associated non-structural proteinrotavirus 'X'-associated non-structural proteinrotavirus X protein associated with NSP3ubiquitous tetratricopeptide containing protein RoXaN	BCL-6 corepressorBCL-6 coreceptorBCL-6 interacting corepressorBCL6 interacting corepressor
	Modification date	20200313	20200328
	UniProtAcc	Q9UGR2	Q5H9F3
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000351589, ENST00000352645,	ENST00000342274, ENST00000378444, ENST00000378455, ENST00000378463, ENST00000397354,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	15 X 12 X 9=1620	6 X 12 X 4=288
	# samples	18	8
	** MAII score	log2(18/1620*10)=-3.16992500144231 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(8/288*10)=-1.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: ZC3H7B [Title/Abstract] AND BCOR [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	BCOR	GO:0035518	histone H2A monoubiquitination	16943429
Tgene	BCOR	GO:0045892	negative regulation of transcription, DNA-templated	10898795

Fusion gene breakpoints across ZC3H7B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across BCOR (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerKB3	.	.	ZC3H7B	chr22	41736141	+	BCOR	chrX	39923103	-
ChimerKB3	.	.	ZC3H7B	chr22	41736141	+	BCOR	chrX	39923205	-
ChimerKB4	.	.	ZC3H7B	chr22	41735819	+	BCOR	chrX	41735819	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000352645	ZC3H7B	chr22	41736141	+	ENST00000378455	BCOR	chrX	39923103	-	3922	1395	254	3058	934
ENST00000352645	ZC3H7B	chr22	41736141	+	ENST00000342274	BCOR	chrX	39923103	-	3920	1395	254	3058	934
ENST00000352645	ZC3H7B	chr22	41736141	+	ENST00000378463	BCOR	chrX	39923103	-	3232	1395	254	3130	958
ENST00000352645	ZC3H7B	chr22	41736141	+	ENST00000397354	BCOR	chrX	39923103	-	3922	1395	254	3058	934
ENST00000352645	ZC3H7B	chr22	41736141	+	ENST00000378444	BCOR	chrX	39923103	-	3920	1395	254	1438	394
ENST00000351589	ZC3H7B	chr22	41736141	+	ENST00000378455	BCOR	chrX	39923103	-	3665	1138	0	2801	933
ENST00000351589	ZC3H7B	chr22	41736141	+	ENST00000342274	BCOR	chrX	39923103	-	3663	1138	0	2801	933
ENST00000351589	ZC3H7B	chr22	41736141	+	ENST00000378463	BCOR	chrX	39923103	-	2975	1138	0	2873	957
ENST00000351589	ZC3H7B	chr22	41736141	+	ENST00000397354	BCOR	chrX	39923103	-	3665	1138	0	2801	933
ENST00000351589	ZC3H7B	chr22	41736141	+	ENST00000378444	BCOR	chrX	39923103	-	3663	1138	0	1181	393

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>100589_100589_1_ZC3H7B-BCOR_ZC3H7B_chr22_41736141_ENST00000351589_BCOR_chrX_39923103_ENST00000342274_length(amino acids)=933AA_BP=379
MERQKRKADIEKGLQFIQSTLPLKQEEYEAFLLKLVQNLFAEGNDLFREKDYKQALVQYMEGLNVADYAASDQVALPRELLCKLHVNRAA
CYFTMGLYEKALEDSEKALGLDSESIRALFRKARALNELGRHKEAYECSSRCSLALPHDESVTQLGQELAQKLGLRVRKAYKRPQELETF
SLLSNGTAAGVADQGTSNGLGSIDDIETDCYVDPRGSPALLPSTPTMPLFPHVLDLLAPLDSSRTLPSTDSLDDFSDGDVFGPELDTLLD
SLSLVQGGLSGSGVPSELPQLIPVFPGGTPLLPPVVGGSIPVSSPLPPASFGLVMDPSKKLAASVLDALDPPGPTLDPLDLLPYSETRLD
ALDSFGSTRGSLDKPDSFMGLHPKKQRHLLHLRERWEQQVSAADGKPGRQSRKEVTQATQPEAIPQGTNITEEKPGRKRAEAKGNRSWSE
ESLKPSDNEQGLPVFSGSPPMKSLSSTSAGGKKQAQPSCAPASRPPAKQQKIKENQKTDVLCADEEEDCQAASLLQKYTDNSEKPSGKRL
CKTKHLIPQESRRGLPLTGEYYVENADGKVTVRRFRKRPEPSSDYDLSPAKQEPKPFDRLQQLLPASQSTQLPCSSSPQETTQSRPMPPE
ARRLIVNKNAGETLLQRAARLGYEEVVLYCLENKICDVNHRDNAGYCALHEACARGWLNIVRHLLEYGADVNCSAQDGTRPLHDAVENDH
LEIVRLLLSYGADPTLATYSGRTIMKMTHSELMEKFLTDYLNDLQGRNDDDASGTWDFYGSSVCEPDDESGYDVLANPPGPEDQDDDDDA
YSDVFEFEFSETPLLPCYNIQVSVAQGPRNWLLLSDVLKKLKMSSRIFRCNFPNVEIVTIAEAEFYRQVSASLLFSCSKDLEAFNPESKE

--------------------------------------------------------------

>100589_100589_2_ZC3H7B-BCOR_ZC3H7B_chr22_41736141_ENST00000351589_BCOR_chrX_39923103_ENST00000378444_length(amino acids)=393AA_BP=
MERQKRKADIEKGLQFIQSTLPLKQEEYEAFLLKLVQNLFAEGNDLFREKDYKQALVQYMEGLNVADYAASDQVALPRELLCKLHVNRAA
CYFTMGLYEKALEDSEKALGLDSESIRALFRKARALNELGRHKEAYECSSRCSLALPHDESVTQLGQELAQKLGLRVRKAYKRPQELETF
SLLSNGTAAGVADQGTSNGLGSIDDIETDCYVDPRGSPALLPSTPTMPLFPHVLDLLAPLDSSRTLPSTDSLDDFSDGDVFGPELDTLLD
SLSLVQGGLSGSGVPSELPQLIPVFPGGTPLLPPVVGGSIPVSSPLPPASFGLVMDPSKKLAASVLDALDPPGPTLDPLDLLPYSETRLD

--------------------------------------------------------------

>100589_100589_3_ZC3H7B-BCOR_ZC3H7B_chr22_41736141_ENST00000351589_BCOR_chrX_39923103_ENST00000378455_length(amino acids)=933AA_BP=379
MERQKRKADIEKGLQFIQSTLPLKQEEYEAFLLKLVQNLFAEGNDLFREKDYKQALVQYMEGLNVADYAASDQVALPRELLCKLHVNRAA
CYFTMGLYEKALEDSEKALGLDSESIRALFRKARALNELGRHKEAYECSSRCSLALPHDESVTQLGQELAQKLGLRVRKAYKRPQELETF
SLLSNGTAAGVADQGTSNGLGSIDDIETDCYVDPRGSPALLPSTPTMPLFPHVLDLLAPLDSSRTLPSTDSLDDFSDGDVFGPELDTLLD
SLSLVQGGLSGSGVPSELPQLIPVFPGGTPLLPPVVGGSIPVSSPLPPASFGLVMDPSKKLAASVLDALDPPGPTLDPLDLLPYSETRLD
ALDSFGSTRGSLDKPDSFMGLHPKKQRHLLHLRERWEQQVSAADGKPGRQSRKEVTQATQPEAIPQGTNITEEKPGRKRAEAKGNRSWSE
ESLKPSDNEQGLPVFSGSPPMKSLSSTSAGGKKQAQPSCAPASRPPAKQQKIKENQKTDVLCADEEEDCQAASLLQKYTDNSEKPSGKRL
CKTKHLIPQESRRGLPLTGEYYVENADGKVTVRRFRKRPEPSSDYDLSPAKQEPKPFDRLQQLLPASQSTQLPCSSSPQETTQSRPMPPE
ARRLIVNKNAGETLLQRAARLGYEEVVLYCLENKICDVNHRDNAGYCALHEACARGWLNIVRHLLEYGADVNCSAQDGTRPLHDAVENDH
LEIVRLLLSYGADPTLATYSGRTIMKMTHSELMEKFLTDYLNDLQGRNDDDASGTWDFYGSSVCEPDDESGYDVLANPPGPEDQDDDDDA
YSDVFEFEFSETPLLPCYNIQVSVAQGPRNWLLLSDVLKKLKMSSRIFRCNFPNVEIVTIAEAEFYRQVSASLLFSCSKDLEAFNPESKE

--------------------------------------------------------------

>100589_100589_4_ZC3H7B-BCOR_ZC3H7B_chr22_41736141_ENST00000351589_BCOR_chrX_39923103_ENST00000378463_length(amino acids)=957AA_BP=379
MERQKRKADIEKGLQFIQSTLPLKQEEYEAFLLKLVQNLFAEGNDLFREKDYKQALVQYMEGLNVADYAASDQVALPRELLCKLHVNRAA
CYFTMGLYEKALEDSEKALGLDSESIRALFRKARALNELGRHKEAYECSSRCSLALPHDESVTQLGQELAQKLGLRVRKAYKRPQELETF
SLLSNGTAAGVADQGTSNGLGSIDDIETDCYVDPRGSPALLPSTPTMPLFPHVLDLLAPLDSSRTLPSTDSLDDFSDGDVFGPELDTLLD
SLSLVQGGLSGSGVPSELPQLIPVFPGGTPLLPPVVGGSIPVSSPLPPASFGLVMDPSKKLAASVLDALDPPGPTLDPLDLLPYSETRLD
ALDSFGSTRGSLDKPDSFMGLHPKKQRHLLHLRERWEQQVSAADGKPGRQSRKEVTQATQPEAIPQGTNITEEKPGRKRAEAKGNRSWSE
ESLKPSDNEQGLPVFSGSPPMKSLSSTSAGGKKQAQPSCAPASRPPAKQQKIKENQKTDVLCADEEEDCQAASLLQKYTDNSEKPSGKRL
CKTKHLIPQESRRGLPLTGEYYVENADGKVTVRRFRKRPEPSSDYDLSPAKQEPKPFDRLQQLLPASQSTQLPCSSSPQETTQSRPMPPE
ARRLIVNKNAGETLLQRAARLGYEEVVLYCLENKICDVNHRDNAGYCALHEACARGWLNIVRHLLEYGADVNCSAQDGTRPLHDAVENDH
LEIVRLLLSYGADPTLATYSGRTIMKMTHSELMEKFLTDYLNDLQGRNDDDASGTWDFYGSSVCEPDDESGYDVLANPPGPEDQDDDDDA
YSDVFEFEFSETPLLPCYNIQVSVAQGPRNWLLLSDVLKKLKMSSRIFRCNFPNVEIVTIAEAEFYRQVSASLLFSCSKDLEAFNPESKE

--------------------------------------------------------------

>100589_100589_5_ZC3H7B-BCOR_ZC3H7B_chr22_41736141_ENST00000351589_BCOR_chrX_39923103_ENST00000397354_length(amino acids)=933AA_BP=379
MERQKRKADIEKGLQFIQSTLPLKQEEYEAFLLKLVQNLFAEGNDLFREKDYKQALVQYMEGLNVADYAASDQVALPRELLCKLHVNRAA
CYFTMGLYEKALEDSEKALGLDSESIRALFRKARALNELGRHKEAYECSSRCSLALPHDESVTQLGQELAQKLGLRVRKAYKRPQELETF
SLLSNGTAAGVADQGTSNGLGSIDDIETDCYVDPRGSPALLPSTPTMPLFPHVLDLLAPLDSSRTLPSTDSLDDFSDGDVFGPELDTLLD
SLSLVQGGLSGSGVPSELPQLIPVFPGGTPLLPPVVGGSIPVSSPLPPASFGLVMDPSKKLAASVLDALDPPGPTLDPLDLLPYSETRLD
ALDSFGSTRGSLDKPDSFMGLHPKKQRHLLHLRERWEQQVSAADGKPGRQSRKEVTQATQPEAIPQGTNITEEKPGRKRAEAKGNRSWSE
ESLKPSDNEQGLPVFSGSPPMKSLSSTSAGGKKQAQPSCAPASRPPAKQQKIKENQKTDVLCADEEEDCQAASLLQKYTDNSEKPSGKRL
CKTKHLIPQESRRGLPLTGEYYVENADGKVTVRRFRKRPEPSSDYDLSPAKQEPKPFDRLQQLLPASQSTQLPCSSSPQETTQSRPMPPE
ARRLIVNKNAGETLLQRAARLGYEEVVLYCLENKICDVNHRDNAGYCALHEACARGWLNIVRHLLEYGADVNCSAQDGTRPLHDAVENDH
LEIVRLLLSYGADPTLATYSGRTIMKMTHSELMEKFLTDYLNDLQGRNDDDASGTWDFYGSSVCEPDDESGYDVLANPPGPEDQDDDDDA
YSDVFEFEFSETPLLPCYNIQVSVAQGPRNWLLLSDVLKKLKMSSRIFRCNFPNVEIVTIAEAEFYRQVSASLLFSCSKDLEAFNPESKE

--------------------------------------------------------------

>100589_100589_6_ZC3H7B-BCOR_ZC3H7B_chr22_41736141_ENST00000352645_BCOR_chrX_39923103_ENST00000342274_length(amino acids)=934AA_BP=380
MMERQKRKADIEKGLQFIQSTLPLKQEEYEAFLLKLVQNLFAEGNDLFREKDYKQALVQYMEGLNVADYAASDQVALPRELLCKLHVNRA
ACYFTMGLYEKALEDSEKALGLDSESIRALFRKARALNELGRHKEAYECSSRCSLALPHDESVTQLGQELAQKLGLRVRKAYKRPQELET
FSLLSNGTAAGVADQGTSNGLGSIDDIETDCYVDPRGSPALLPSTPTMPLFPHVLDLLAPLDSSRTLPSTDSLDDFSDGDVFGPELDTLL
DSLSLVQGGLSGSGVPSELPQLIPVFPGGTPLLPPVVGGSIPVSSPLPPASFGLVMDPSKKLAASVLDALDPPGPTLDPLDLLPYSETRL
DALDSFGSTRGSLDKPDSFMGLHPKKQRHLLHLRERWEQQVSAADGKPGRQSRKEVTQATQPEAIPQGTNITEEKPGRKRAEAKGNRSWS
EESLKPSDNEQGLPVFSGSPPMKSLSSTSAGGKKQAQPSCAPASRPPAKQQKIKENQKTDVLCADEEEDCQAASLLQKYTDNSEKPSGKR
LCKTKHLIPQESRRGLPLTGEYYVENADGKVTVRRFRKRPEPSSDYDLSPAKQEPKPFDRLQQLLPASQSTQLPCSSSPQETTQSRPMPP
EARRLIVNKNAGETLLQRAARLGYEEVVLYCLENKICDVNHRDNAGYCALHEACARGWLNIVRHLLEYGADVNCSAQDGTRPLHDAVEND
HLEIVRLLLSYGADPTLATYSGRTIMKMTHSELMEKFLTDYLNDLQGRNDDDASGTWDFYGSSVCEPDDESGYDVLANPPGPEDQDDDDD
AYSDVFEFEFSETPLLPCYNIQVSVAQGPRNWLLLSDVLKKLKMSSRIFRCNFPNVEIVTIAEAEFYRQVSASLLFSCSKDLEAFNPESK

--------------------------------------------------------------

>100589_100589_7_ZC3H7B-BCOR_ZC3H7B_chr22_41736141_ENST00000352645_BCOR_chrX_39923103_ENST00000378444_length(amino acids)=394AA_BP=
MMERQKRKADIEKGLQFIQSTLPLKQEEYEAFLLKLVQNLFAEGNDLFREKDYKQALVQYMEGLNVADYAASDQVALPRELLCKLHVNRA
ACYFTMGLYEKALEDSEKALGLDSESIRALFRKARALNELGRHKEAYECSSRCSLALPHDESVTQLGQELAQKLGLRVRKAYKRPQELET
FSLLSNGTAAGVADQGTSNGLGSIDDIETDCYVDPRGSPALLPSTPTMPLFPHVLDLLAPLDSSRTLPSTDSLDDFSDGDVFGPELDTLL
DSLSLVQGGLSGSGVPSELPQLIPVFPGGTPLLPPVVGGSIPVSSPLPPASFGLVMDPSKKLAASVLDALDPPGPTLDPLDLLPYSETRL

--------------------------------------------------------------

>100589_100589_8_ZC3H7B-BCOR_ZC3H7B_chr22_41736141_ENST00000352645_BCOR_chrX_39923103_ENST00000378455_length(amino acids)=934AA_BP=380
MMERQKRKADIEKGLQFIQSTLPLKQEEYEAFLLKLVQNLFAEGNDLFREKDYKQALVQYMEGLNVADYAASDQVALPRELLCKLHVNRA
ACYFTMGLYEKALEDSEKALGLDSESIRALFRKARALNELGRHKEAYECSSRCSLALPHDESVTQLGQELAQKLGLRVRKAYKRPQELET
FSLLSNGTAAGVADQGTSNGLGSIDDIETDCYVDPRGSPALLPSTPTMPLFPHVLDLLAPLDSSRTLPSTDSLDDFSDGDVFGPELDTLL
DSLSLVQGGLSGSGVPSELPQLIPVFPGGTPLLPPVVGGSIPVSSPLPPASFGLVMDPSKKLAASVLDALDPPGPTLDPLDLLPYSETRL
DALDSFGSTRGSLDKPDSFMGLHPKKQRHLLHLRERWEQQVSAADGKPGRQSRKEVTQATQPEAIPQGTNITEEKPGRKRAEAKGNRSWS
EESLKPSDNEQGLPVFSGSPPMKSLSSTSAGGKKQAQPSCAPASRPPAKQQKIKENQKTDVLCADEEEDCQAASLLQKYTDNSEKPSGKR
LCKTKHLIPQESRRGLPLTGEYYVENADGKVTVRRFRKRPEPSSDYDLSPAKQEPKPFDRLQQLLPASQSTQLPCSSSPQETTQSRPMPP
EARRLIVNKNAGETLLQRAARLGYEEVVLYCLENKICDVNHRDNAGYCALHEACARGWLNIVRHLLEYGADVNCSAQDGTRPLHDAVEND
HLEIVRLLLSYGADPTLATYSGRTIMKMTHSELMEKFLTDYLNDLQGRNDDDASGTWDFYGSSVCEPDDESGYDVLANPPGPEDQDDDDD
AYSDVFEFEFSETPLLPCYNIQVSVAQGPRNWLLLSDVLKKLKMSSRIFRCNFPNVEIVTIAEAEFYRQVSASLLFSCSKDLEAFNPESK

--------------------------------------------------------------

>100589_100589_9_ZC3H7B-BCOR_ZC3H7B_chr22_41736141_ENST00000352645_BCOR_chrX_39923103_ENST00000378463_length(amino acids)=958AA_BP=380
MMERQKRKADIEKGLQFIQSTLPLKQEEYEAFLLKLVQNLFAEGNDLFREKDYKQALVQYMEGLNVADYAASDQVALPRELLCKLHVNRA
ACYFTMGLYEKALEDSEKALGLDSESIRALFRKARALNELGRHKEAYECSSRCSLALPHDESVTQLGQELAQKLGLRVRKAYKRPQELET
FSLLSNGTAAGVADQGTSNGLGSIDDIETDCYVDPRGSPALLPSTPTMPLFPHVLDLLAPLDSSRTLPSTDSLDDFSDGDVFGPELDTLL
DSLSLVQGGLSGSGVPSELPQLIPVFPGGTPLLPPVVGGSIPVSSPLPPASFGLVMDPSKKLAASVLDALDPPGPTLDPLDLLPYSETRL
DALDSFGSTRGSLDKPDSFMGLHPKKQRHLLHLRERWEQQVSAADGKPGRQSRKEVTQATQPEAIPQGTNITEEKPGRKRAEAKGNRSWS
EESLKPSDNEQGLPVFSGSPPMKSLSSTSAGGKKQAQPSCAPASRPPAKQQKIKENQKTDVLCADEEEDCQAASLLQKYTDNSEKPSGKR
LCKTKHLIPQESRRGLPLTGEYYVENADGKVTVRRFRKRPEPSSDYDLSPAKQEPKPFDRLQQLLPASQSTQLPCSSSPQETTQSRPMPP
EARRLIVNKNAGETLLQRAARLGYEEVVLYCLENKICDVNHRDNAGYCALHEACARGWLNIVRHLLEYGADVNCSAQDGTRPLHDAVEND
HLEIVRLLLSYGADPTLATYSGRTIMKMTHSELMEKFLTDYLNDLQGRNDDDASGTWDFYGSSVCEPDDESGYDVLANPPGPEDQDDDDD
AYSDVFEFEFSETPLLPCYNIQVSVAQGPRNWLLLSDVLKKLKMSSRIFRCNFPNVEIVTIAEAEFYRQVSASLLFSCSKDLEAFNPESK

--------------------------------------------------------------

>100589_100589_10_ZC3H7B-BCOR_ZC3H7B_chr22_41736141_ENST00000352645_BCOR_chrX_39923103_ENST00000397354_length(amino acids)=934AA_BP=380
MMERQKRKADIEKGLQFIQSTLPLKQEEYEAFLLKLVQNLFAEGNDLFREKDYKQALVQYMEGLNVADYAASDQVALPRELLCKLHVNRA
ACYFTMGLYEKALEDSEKALGLDSESIRALFRKARALNELGRHKEAYECSSRCSLALPHDESVTQLGQELAQKLGLRVRKAYKRPQELET
FSLLSNGTAAGVADQGTSNGLGSIDDIETDCYVDPRGSPALLPSTPTMPLFPHVLDLLAPLDSSRTLPSTDSLDDFSDGDVFGPELDTLL
DSLSLVQGGLSGSGVPSELPQLIPVFPGGTPLLPPVVGGSIPVSSPLPPASFGLVMDPSKKLAASVLDALDPPGPTLDPLDLLPYSETRL
DALDSFGSTRGSLDKPDSFMGLHPKKQRHLLHLRERWEQQVSAADGKPGRQSRKEVTQATQPEAIPQGTNITEEKPGRKRAEAKGNRSWS
EESLKPSDNEQGLPVFSGSPPMKSLSSTSAGGKKQAQPSCAPASRPPAKQQKIKENQKTDVLCADEEEDCQAASLLQKYTDNSEKPSGKR
LCKTKHLIPQESRRGLPLTGEYYVENADGKVTVRRFRKRPEPSSDYDLSPAKQEPKPFDRLQQLLPASQSTQLPCSSSPQETTQSRPMPP
EARRLIVNKNAGETLLQRAARLGYEEVVLYCLENKICDVNHRDNAGYCALHEACARGWLNIVRHLLEYGADVNCSAQDGTRPLHDAVEND
HLEIVRLLLSYGADPTLATYSGRTIMKMTHSELMEKFLTDYLNDLQGRNDDDASGTWDFYGSSVCEPDDESGYDVLANPPGPEDQDDDDD
AYSDVFEFEFSETPLLPCYNIQVSVAQGPRNWLLLSDVLKKLKMSSRIFRCNFPNVEIVTIAEAEFYRQVSASLLFSCSKDLEAFNPESK

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr22:/chrX:)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
ZC3H7B Q9UGR2	BCOR Q5H9F3
FUNCTION: May be a specific regulator of miRNA biogenesis. Binds to microRNAs MIR7-1, MIR16-2 and MIR29A hairpins recognizing the 'ATA(A/T)' motif in the apical loop. {ECO:0000269\|PubMed:28431233}.	FUNCTION: Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence-specific DNA-binding proteins such as BCL6. This repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor. {ECO:0000269\|PubMed:17379597}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	AA seq	Len(AA seq)

PDB file (150) >>>150.pdbFusion protein BP residue: CIF file (150) >>>150.cif	ZC3H7B	chr22	41736141	+	BCOR	chrX	39923103	-	MERQKRKADIEKGLQFIQSTLPLKQEEYEAFLLKLVQNLFAEGNDLFREK DYKQALVQYMEGLNVADYAASDQVALPRELLCKLHVNRAACYFTMGLYEK ALEDSEKALGLDSESIRALFRKARALNELGRHKEAYECSSRCSLALPHDE SVTQLGQELAQKLGLRVRKAYKRPQELETFSLLSNGTAAGVADQGTSNGL GSIDDIETDCYVDPRGSPALLPSTPTMPLFPHVLDLLAPLDSSRTLPSTD SLDDFSDGDVFGPELDTLLDSLSLVQGGLSGSGVPSELPQLIPVFPGGTP LLPPVVGGSIPVSSPLPPASFGLVMDPSKKLAASVLDALDPPGPTLDPLD	393
3D view using mol* of 150 (AA BP:)


PDB file (152) >>>152.pdbFusion protein BP residue: CIF file (152) >>>152.cif	ZC3H7B	chr22	41736141	+	BCOR	chrX	39923103	-	MMERQKRKADIEKGLQFIQSTLPLKQEEYEAFLLKLVQNLFAEGNDLFRE KDYKQALVQYMEGLNVADYAASDQVALPRELLCKLHVNRAACYFTMGLYE KALEDSEKALGLDSESIRALFRKARALNELGRHKEAYECSSRCSLALPHD ESVTQLGQELAQKLGLRVRKAYKRPQELETFSLLSNGTAAGVADQGTSNG LGSIDDIETDCYVDPRGSPALLPSTPTMPLFPHVLDLLAPLDSSRTLPST DSLDDFSDGDVFGPELDTLLDSLSLVQGGLSGSGVPSELPQLIPVFPGGT PLLPPVVGGSIPVSSPLPPASFGLVMDPSKKLAASVLDALDPPGPTLDPL	394
3D view using mol* of 152 (AA BP:)


PDB file (715) >>>715.pdbFusion protein BP residue: 379 CIF file (715) >>>715.cif	ZC3H7B	chr22	41736141	+	BCOR	chrX	39923103	-	MERQKRKADIEKGLQFIQSTLPLKQEEYEAFLLKLVQNLFAEGNDLFREK DYKQALVQYMEGLNVADYAASDQVALPRELLCKLHVNRAACYFTMGLYEK ALEDSEKALGLDSESIRALFRKARALNELGRHKEAYECSSRCSLALPHDE SVTQLGQELAQKLGLRVRKAYKRPQELETFSLLSNGTAAGVADQGTSNGL GSIDDIETDCYVDPRGSPALLPSTPTMPLFPHVLDLLAPLDSSRTLPSTD SLDDFSDGDVFGPELDTLLDSLSLVQGGLSGSGVPSELPQLIPVFPGGTP LLPPVVGGSIPVSSPLPPASFGLVMDPSKKLAASVLDALDPPGPTLDPLD LLPYSETRLDALDSFGSTRGSLDKPDSFMGLHPKKQRHLLHLRERWEQQV SAADGKPGRQSRKEVTQATQPEAIPQGTNITEEKPGRKRAEAKGNRSWSE ESLKPSDNEQGLPVFSGSPPMKSLSSTSAGGKKQAQPSCAPASRPPAKQQ KIKENQKTDVLCADEEEDCQAASLLQKYTDNSEKPSGKRLCKTKHLIPQE SRRGLPLTGEYYVENADGKVTVRRFRKRPEPSSDYDLSPAKQEPKPFDRL QQLLPASQSTQLPCSSSPQETTQSRPMPPEARRLIVNKNAGETLLQRAAR LGYEEVVLYCLENKICDVNHRDNAGYCALHEACARGWLNIVRHLLEYGAD VNCSAQDGTRPLHDAVENDHLEIVRLLLSYGADPTLATYSGRTIMKMTHS ELMEKFLTDYLNDLQGRNDDDASGTWDFYGSSVCEPDDESGYDVLANPPG PEDQDDDDDAYSDVFEFEFSETPLLPCYNIQVSVAQGPRNWLLLSDVLKK LKMSSRIFRCNFPNVEIVTIAEAEFYRQVSASLLFSCSKDLEAFNPESKE	933
3D view using mol* of 715 (AA BP:379)


PDB file (716) >>>716.pdbFusion protein BP residue: 380 CIF file (716) >>>716.cif	ZC3H7B	chr22	41736141	+	BCOR	chrX	39923103	-	MMERQKRKADIEKGLQFIQSTLPLKQEEYEAFLLKLVQNLFAEGNDLFRE KDYKQALVQYMEGLNVADYAASDQVALPRELLCKLHVNRAACYFTMGLYE KALEDSEKALGLDSESIRALFRKARALNELGRHKEAYECSSRCSLALPHD ESVTQLGQELAQKLGLRVRKAYKRPQELETFSLLSNGTAAGVADQGTSNG LGSIDDIETDCYVDPRGSPALLPSTPTMPLFPHVLDLLAPLDSSRTLPST DSLDDFSDGDVFGPELDTLLDSLSLVQGGLSGSGVPSELPQLIPVFPGGT PLLPPVVGGSIPVSSPLPPASFGLVMDPSKKLAASVLDALDPPGPTLDPL DLLPYSETRLDALDSFGSTRGSLDKPDSFMGLHPKKQRHLLHLRERWEQQ VSAADGKPGRQSRKEVTQATQPEAIPQGTNITEEKPGRKRAEAKGNRSWS EESLKPSDNEQGLPVFSGSPPMKSLSSTSAGGKKQAQPSCAPASRPPAKQ QKIKENQKTDVLCADEEEDCQAASLLQKYTDNSEKPSGKRLCKTKHLIPQ ESRRGLPLTGEYYVENADGKVTVRRFRKRPEPSSDYDLSPAKQEPKPFDR LQQLLPASQSTQLPCSSSPQETTQSRPMPPEARRLIVNKNAGETLLQRAA RLGYEEVVLYCLENKICDVNHRDNAGYCALHEACARGWLNIVRHLLEYGA DVNCSAQDGTRPLHDAVENDHLEIVRLLLSYGADPTLATYSGRTIMKMTH SELMEKFLTDYLNDLQGRNDDDASGTWDFYGSSVCEPDDESGYDVLANPP GPEDQDDDDDAYSDVFEFEFSETPLLPCYNIQVSVAQGPRNWLLLSDVLK KLKMSSRIFRCNFPNVEIVTIAEAEFYRQVSASLLFSCSKDLEAFNPESK	934
3D view using mol* of 716 (AA BP:380)


PDB file (731) >>>731.pdbFusion protein BP residue: 379 CIF file (731) >>>731.cif	ZC3H7B	chr22	41736141	+	BCOR	chrX	39923103	-	MERQKRKADIEKGLQFIQSTLPLKQEEYEAFLLKLVQNLFAEGNDLFREK DYKQALVQYMEGLNVADYAASDQVALPRELLCKLHVNRAACYFTMGLYEK ALEDSEKALGLDSESIRALFRKARALNELGRHKEAYECSSRCSLALPHDE SVTQLGQELAQKLGLRVRKAYKRPQELETFSLLSNGTAAGVADQGTSNGL GSIDDIETDCYVDPRGSPALLPSTPTMPLFPHVLDLLAPLDSSRTLPSTD SLDDFSDGDVFGPELDTLLDSLSLVQGGLSGSGVPSELPQLIPVFPGGTP LLPPVVGGSIPVSSPLPPASFGLVMDPSKKLAASVLDALDPPGPTLDPLD LLPYSETRLDALDSFGSTRGSLDKPDSFMGLHPKKQRHLLHLRERWEQQV SAADGKPGRQSRKEVTQATQPEAIPQGTNITEEKPGRKRAEAKGNRSWSE ESLKPSDNEQGLPVFSGSPPMKSLSSTSAGGKKQAQPSCAPASRPPAKQQ KIKENQKTDVLCADEEEDCQAASLLQKYTDNSEKPSGKRLCKTKHLIPQE SRRGLPLTGEYYVENADGKVTVRRFRKRPEPSSDYDLSPAKQEPKPFDRL QQLLPASQSTQLPCSSSPQETTQSRPMPPEARRLIVNKNAGETLLQRAAR LGYEEVVLYCLENKICDVNHRDNAGYCALHEACARGWLNIVRHLLEYGAD VNCSAQDGTRPLHDAVENDHLEIVRLLLSYGADPTLATYSGRTIMKMTHS ELMEKFLTDYLNDLQGRNDDDASGTWDFYGSSVCEPDDESGYDVLANPPG PEDQDDDDDAYSDVFEFEFSETPLLPCYNIQVSVAQGPRNWLLLSDVLKK LKMSSRIFRCNFPNVEIVTIAEAEFYRQVSASLLFSCSKDLEAFNPESKE LLDLVEFTNEIQTLLGSSVEWLHPSDLASDNYWKSPQIARGSVEGKKTDD	957
3D view using mol* of 731 (AA BP:379)


PDB file (733) >>>733.pdbFusion protein BP residue: 380 CIF file (733) >>>733.cif	ZC3H7B	chr22	41736141	+	BCOR	chrX	39923103	-	MMERQKRKADIEKGLQFIQSTLPLKQEEYEAFLLKLVQNLFAEGNDLFRE KDYKQALVQYMEGLNVADYAASDQVALPRELLCKLHVNRAACYFTMGLYE KALEDSEKALGLDSESIRALFRKARALNELGRHKEAYECSSRCSLALPHD ESVTQLGQELAQKLGLRVRKAYKRPQELETFSLLSNGTAAGVADQGTSNG LGSIDDIETDCYVDPRGSPALLPSTPTMPLFPHVLDLLAPLDSSRTLPST DSLDDFSDGDVFGPELDTLLDSLSLVQGGLSGSGVPSELPQLIPVFPGGT PLLPPVVGGSIPVSSPLPPASFGLVMDPSKKLAASVLDALDPPGPTLDPL DLLPYSETRLDALDSFGSTRGSLDKPDSFMGLHPKKQRHLLHLRERWEQQ VSAADGKPGRQSRKEVTQATQPEAIPQGTNITEEKPGRKRAEAKGNRSWS EESLKPSDNEQGLPVFSGSPPMKSLSSTSAGGKKQAQPSCAPASRPPAKQ QKIKENQKTDVLCADEEEDCQAASLLQKYTDNSEKPSGKRLCKTKHLIPQ ESRRGLPLTGEYYVENADGKVTVRRFRKRPEPSSDYDLSPAKQEPKPFDR LQQLLPASQSTQLPCSSSPQETTQSRPMPPEARRLIVNKNAGETLLQRAA RLGYEEVVLYCLENKICDVNHRDNAGYCALHEACARGWLNIVRHLLEYGA DVNCSAQDGTRPLHDAVENDHLEIVRLLLSYGADPTLATYSGRTIMKMTH SELMEKFLTDYLNDLQGRNDDDASGTWDFYGSSVCEPDDESGYDVLANPP GPEDQDDDDDAYSDVFEFEFSETPLLPCYNIQVSVAQGPRNWLLLSDVLK KLKMSSRIFRCNFPNVEIVTIAEAEFYRQVSASLLFSCSKDLEAFNPESK ELLDLVEFTNEIQTLLGSSVEWLHPSDLASDNYWKSPQIARGSVEGKKTD	958
3D view using mol* of 733 (AA BP:380)

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pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

ZC3H7B_pLDDT.png

BCOR_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

ZC3H7B_BCOR_150_PAE.png (AA BP:)

ZC3H7B_BCOR_150_pLDDT.png (AA BP:)

ZC3H7B_BCOR_150_pLDDT_and_active_sites.png (AA BP:)

ZC3H7B_BCOR_150_violinplot.png (AA BP:)

ZC3H7B_BCOR_152_PAE.png (AA BP:)

ZC3H7B_BCOR_152_pLDDT.png (AA BP:)

ZC3H7B_BCOR_152_pLDDT_and_active_sites.png (AA BP:)

ZC3H7B_BCOR_152_violinplot.png (AA BP:)

ZC3H7B_BCOR_715_pLDDT.png (AA BP:379)

ZC3H7B_BCOR_715_pLDDT_and_active_sites.png (AA BP:379)

ZC3H7B_BCOR_715_violinplot.png (AA BP:379)

ZC3H7B_BCOR_716_pLDDT.png (AA BP:380)

ZC3H7B_BCOR_716_pLDDT_and_active_sites.png (AA BP:380)

ZC3H7B_BCOR_716_violinplot.png (AA BP:380)

ZC3H7B_BCOR_731_pLDDT.png (AA BP:379)

ZC3H7B_BCOR_731_pLDDT_and_active_sites.png (AA BP:379)

ZC3H7B_BCOR_731_violinplot.png (AA BP:379)

ZC3H7B_BCOR_733_pLDDT.png (AA BP:380)

ZC3H7B_BCOR_733_pLDDT_and_active_sites.png (AA BP:380)

ZC3H7B_BCOR_733_violinplot.png (AA BP:380)

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Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

ZC3H7B_BCOR_150.png

ZC3H7B_BCOR_152.png

ZC3H7B_BCOR_716.png

ZC3H7B_BCOR_731.png

ZC3H7B_BCOR_733.png

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Potential Active Site Information

The potential binding sites of these fusion proteins were identified using SiteMap, a module of the Schrodinger suite.

Fusion AA seq ID in FusionPDB	Site score	Size	D score	Volume	Exposure	Enclosure	Contact	Phobic	Philic	Balance	Don/Acc	Residues
150	1.007	126	1.079	403.368	0.683	0.608	0.761	0.762	0.691	1.103	1.118	Chain A: 7,10,11,14,15,17,18,39,42,46,54,57,58,61, 64,65,68,321,322,323,325,326,327,328,330,331
152	1.023	93	1.083	454.475	0.698	0.673	0.805	1.181	0.697	1.694	0.59	Chain A: 8,9,11,12,15,16,18,19,43,47,55,58,59,62,6 5,66,69,324,325,326,327,328,329,330,331,332,333
715	0.98	282	1.015	748.426	0.618	0.641	0.85	0.576	0.95	0.606	0.546	Chain A: 2,5,6,9,29,30,33,34,37,38,40,41,44,45,47, 48,50,52,74,75,76,77,78,79,80,82,83,89,90,93,94,10 1,112,115,116,117,120,121,124,125,146,198,199,200, 201,203,204,205,206,207,208,209,210,211,212,213,21 4
716	1.03	322	1.067	968.975	0.586	0.705	0.933	0.801	0.909	0.882	1.06	Chain A: 376,378,379,380,381,382,386,389,390,391,3 93,394,396,397,398,400,689,693,696,697,699,700,701 ,702,703,723,726,727,729,730,731,732,733,734,735,7 53,756,757,760,761,763,764,765,767,768,772,773,775 ,777,778,779,780,781,783,784,785
731	1.0174	166	1.0753	737.45	0.6783	0.6485	0.8034	0.8348	0.7785	1.0723	0.6977	Chain A: 114,116,119,133,136,137,139,140,141,142,1 43,144,145,153,156,157,160,165,166,167,168,290,291 ,292,293,294,295,296,297,298,299,300,704,708,710,7 35,736,737,738,739,741,743
733	1.0232	160	1.0752	376.957	0.5322	0.6671	0.8684	0.6185	0.8131	0.7606	1.0831	Chain A: 137,140,141,144,145,148,149,154,157,158,1 61,166,168,171,172,173,286,287,288,289,290,291,292 ,293,294

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Potentially Interacting Small Molecules through Virtual Screening

The FDA-approved small molecule library molecules were subjected to virtual screening using the Glide.

Fusion AA seq ID in FusionPDB

ZINC ID

DrugBank ID

Drug name

Docking score

Glide gscore

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Drug information from DrugBank of the top 20 interacting small molecules.

ZINC ID

DrugBank ID

Drug name

Drug type

SMILES

Drug group

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Biochemical Features of Small Molecules

ADME (Absorption, Distribution, Metabolism, and Excretion) of drugs using QikProp(v3.9)

ZINC ID

mol_MW

dipole

SASA

FOSA

FISA

PISA

WPSA

volume

donorHB

accptHB

Human Oral Absorption

Percent Human Oral Absorption

Rule Of Five

Rule Of Three

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Drug Toxicity Information

Toxicity information of individual drugs using eToxPred

ZINC ID

Smile

Surface Accessibility

Toxicity

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene	PPI interactors
ZC3H7B	ATXN1, ATXN1L, ZYX, UBXN6, RC3H1, HSP90AA1, HECW2, MOV10, NXF1, TRIM25, G3BP1, KIAA1429, ZC3H7A, TRIM28, OBSL1, PLEKHA4, MIR7-1, MIR16-2, MIR29A, MIR205, ZNF638, DDX21, ESR1, FXR1, FXR2, RNF214, FMR1, ZFP36, N, SERBP1, HNRNPCL2, METTL21B,

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
ZC3H7B
BCOR

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs to ZC3H7B-BCOR

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to ZC3H7B-BCOR

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene	Tgene	Disease	Source	PMID
ZC3H7B	BCOR	Lung Adenocarcinoma	MyCancerGenome
ZC3H7B	BCOR	Acute Myeloid Leukemia	MyCancerGenome
ZC3H7B	BCOR	Breast Invasive Lobular Carcinoma	MyCancerGenome
ZC3H7B	BCOR	Cancer Of Unknown Primary	MyCancerGenome
ZC3H7B	BCOR	Colon Adenocarcinoma	MyCancerGenome

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Tgene	BCOR	C1846265	Microphthalmia, syndromic 2	4	CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
Tgene	BCOR	C0023487	Acute Promyelocytic Leukemia	2	ORPHANET
Tgene	BCOR	C0010606	Adenoid Cystic Carcinoma	1	CTD_human
Tgene	BCOR	C0022665	Kidney Neoplasm	1	CTD_human
Tgene	BCOR	C0027708	Nephroblastoma	1	CTD_human
Tgene	BCOR	C0029463	Osteosarcoma	1	CTD_human
Tgene	BCOR	C0206651	Clear Cell Sarcoma of Soft Tissue	1	CTD_human
Tgene	BCOR	C0206656	Embryonal Rhabdomyosarcoma	1	CTD_human
Tgene	BCOR	C0334488	Clear cell sarcoma of kidney	1	ORPHANET
Tgene	BCOR	C0740457	Malignant neoplasm of kidney	1	CTD_human
Tgene	BCOR	C0796016	Microphthalmia, syndromic 1	1	CTD_human;ORPHANET
Tgene	BCOR	C2930471	Bilateral Wilms Tumor	1	CTD_human