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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:ZEB1-TAOK3

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: ZEB1-TAOK3
FusionPDB ID: 100861
FusionGDB2.0 ID: 100861
HgeneTgene
Gene symbol

ZEB1

TAOK3

Gene ID

6935

51347

Gene namezinc finger E-box binding homeobox 1TAO kinase 3
SynonymsAREB6|BZP|DELTAEF1|FECD6|NIL2A|PPCD3|TCF8|ZFHEP|ZFHX1ADPK|JIK|MAP3K18|hKFC-A
Cytomap

10p11.22

12q24.23

Type of geneprotein-codingprotein-coding
Descriptionzinc finger E-box-binding homeobox 1delta-crystallin enhancer binding factor 1negative regulator of IL2posterior polymorphous corneal dystrophy 3transcription factor 8 (represses interleukin 2 expression)zinc finger homeodomain enhancer-binding proteserine/threonine-protein kinase TAO3CTCL-associated antigen HD-CL-09JNK/SAPK-inhibitory kinaseSTE20-like kinasecutaneous T-cell lymphoma-associated antigen HD-CL-09dendritic cell-derived protein kinasejun kinase-inhibitory kinasekinase from chicken
Modification date2020032920200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST idsENST00000559858, ENST00000320985, 
ENST00000361642, ENST00000542815, 
ENST00000560721, ENST00000446923, 
ENST00000392533, ENST00000419821, 
ENST00000536979, ENST00000537952, 
ENST00000543709, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score11 X 5 X 8=44013 X 15 X 5=975
# samples 1316
** MAII scorelog2(13/440*10)=-1.7589919004962
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(16/975*10)=-2.60733031374961
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: ZEB1 [Title/Abstract] AND TAOK3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)ZEB1(31608221)-TAOK3(118651915), # samples:1
Anticipated loss of major functional domain due to fusion event.ZEB1-TAOK3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ZEB1-TAOK3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ZEB1-TAOK3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ZEB1-TAOK3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneZEB1

GO:0000122

negative regulation of transcription by RNA polymerase II

23765923|23814079

HgeneZEB1

GO:0045892

negative regulation of transcription, DNA-templated

20418909

TgeneTAOK3

GO:0006468

protein phosphorylation

10559204

TgeneTAOK3

GO:0006974

cellular response to DNA damage stimulus

17396146

TgeneTAOK3

GO:0046329

negative regulation of JNK cascade

10559204

TgeneTAOK3

GO:0046777

protein autophosphorylation

10559204


check buttonFusion gene breakpoints across ZEB1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across TAOK3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-CD-A4MJZEB1chr10

31608221

+TAOK3chr12

118651915

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000320985ZEB1chr1031608221+ENST00000419821TAOK3chr12118651915-34181681102221703
ENST00000320985ZEB1chr1031608221+ENST00000392533TAOK3chr12118651915-34181681102221703
ENST00000361642ZEB1chr1031608221+ENST00000419821TAOK3chr12118651915-3371121632174703
ENST00000361642ZEB1chr1031608221+ENST00000392533TAOK3chr12118651915-3371121632174703
ENST00000560721ZEB1chr1031608221+ENST00000419821TAOK3chr12118651915-333181232134703
ENST00000560721ZEB1chr1031608221+ENST00000392533TAOK3chr12118651915-333181232134703
ENST00000542815ZEB1chr1031608221+ENST00000419821TAOK3chr12118651915-332171132124703
ENST00000542815ZEB1chr1031608221+ENST00000392533TAOK3chr12118651915-332171132124703

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000320985ENST00000419821ZEB1chr1031608221+TAOK3chr12118651915-0.0076965460.9923035
ENST00000320985ENST00000392533ZEB1chr1031608221+TAOK3chr12118651915-0.0076965460.9923035
ENST00000361642ENST00000419821ZEB1chr1031608221+TAOK3chr12118651915-0.0083059730.99169403
ENST00000361642ENST00000392533ZEB1chr1031608221+TAOK3chr12118651915-0.0083059730.99169403
ENST00000560721ENST00000419821ZEB1chr1031608221+TAOK3chr12118651915-0.0085068770.99149317
ENST00000560721ENST00000392533ZEB1chr1031608221+TAOK3chr12118651915-0.0085068770.99149317
ENST00000542815ENST00000419821ZEB1chr1031608221+TAOK3chr12118651915-0.0086107240.99138933
ENST00000542815ENST00000392533ZEB1chr1031608221+TAOK3chr12118651915-0.0086107240.99138933

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>100861_100861_1_ZEB1-TAOK3_ZEB1_chr10_31608221_ENST00000320985_TAOK3_chr12_118651915_ENST00000392533_length(amino acids)=703AA_BP=19
MADGPRCKRRKQANPRRNNAERKPPLFNMNAMSALYHIAQNDSPTLQSNEWTDSFRRFVDYCLQKIPQERPTSAELLRHDFVRRDRPLRV
LIDLIQRTKDAVRELDNLQYRKMKKILFQETRNGPLNESQEDEEDSEHGTSLNREMDSLGSNHSIPSMSVSTGSQSSSVNSMQEVMDESS
SELVMMHDDESTINSSSSVVHKKDHVFIRDEAGHGDPRPEPRPTQSVQSQALHYRNRERFATIKSASLVTRQIHEHEQENELREQMSGYK
RMRRQHQKQLIALENKLKAEMDEHRLKLQKEVETHANNSSIELEKLAKKQVAIIEKEAKVAAADEKKFQQQILAQQKKDLTTFLESQKKQ
YKICKEKIKEEMNEDHSTPKKEKQERISKHKENLQHTQAEEEAHLLTQQRLYYDKNCRFFKRKIMIKRHEVEQQNIREELNKKRTQKEME
HAMLIRHDESTRELEYRQLHTLQKLRMDLIRLQHQTELENQLEYNKRRERELHRKHVMELRQQPKNLKAMEMQIKKQFQDTCKVQTKQYK
ALKNHQLEVTPKNEHKTILKTLKDEQTRKLAILAEQYEQSINEMMASQALRLDEAQEAECQALRLQLQQEMELLNAYQSKIKMQTEAQHE

--------------------------------------------------------------

>100861_100861_2_ZEB1-TAOK3_ZEB1_chr10_31608221_ENST00000320985_TAOK3_chr12_118651915_ENST00000419821_length(amino acids)=703AA_BP=19
MADGPRCKRRKQANPRRNNAERKPPLFNMNAMSALYHIAQNDSPTLQSNEWTDSFRRFVDYCLQKIPQERPTSAELLRHDFVRRDRPLRV
LIDLIQRTKDAVRELDNLQYRKMKKILFQETRNGPLNESQEDEEDSEHGTSLNREMDSLGSNHSIPSMSVSTGSQSSSVNSMQEVMDESS
SELVMMHDDESTINSSSSVVHKKDHVFIRDEAGHGDPRPEPRPTQSVQSQALHYRNRERFATIKSASLVTRQIHEHEQENELREQMSGYK
RMRRQHQKQLIALENKLKAEMDEHRLKLQKEVETHANNSSIELEKLAKKQVAIIEKEAKVAAADEKKFQQQILAQQKKDLTTFLESQKKQ
YKICKEKIKEEMNEDHSTPKKEKQERISKHKENLQHTQAEEEAHLLTQQRLYYDKNCRFFKRKIMIKRHEVEQQNIREELNKKRTQKEME
HAMLIRHDESTRELEYRQLHTLQKLRMDLIRLQHQTELENQLEYNKRRERELHRKHVMELRQQPKNLKAMEMQIKKQFQDTCKVQTKQYK
ALKNHQLEVTPKNEHKTILKTLKDEQTRKLAILAEQYEQSINEMMASQALRLDEAQEAECQALRLQLQQEMELLNAYQSKIKMQTEAQHE

--------------------------------------------------------------

>100861_100861_3_ZEB1-TAOK3_ZEB1_chr10_31608221_ENST00000361642_TAOK3_chr12_118651915_ENST00000392533_length(amino acids)=703AA_BP=19
MADGPRCKRRKQANPRRNNAERKPPLFNMNAMSALYHIAQNDSPTLQSNEWTDSFRRFVDYCLQKIPQERPTSAELLRHDFVRRDRPLRV
LIDLIQRTKDAVRELDNLQYRKMKKILFQETRNGPLNESQEDEEDSEHGTSLNREMDSLGSNHSIPSMSVSTGSQSSSVNSMQEVMDESS
SELVMMHDDESTINSSSSVVHKKDHVFIRDEAGHGDPRPEPRPTQSVQSQALHYRNRERFATIKSASLVTRQIHEHEQENELREQMSGYK
RMRRQHQKQLIALENKLKAEMDEHRLKLQKEVETHANNSSIELEKLAKKQVAIIEKEAKVAAADEKKFQQQILAQQKKDLTTFLESQKKQ
YKICKEKIKEEMNEDHSTPKKEKQERISKHKENLQHTQAEEEAHLLTQQRLYYDKNCRFFKRKIMIKRHEVEQQNIREELNKKRTQKEME
HAMLIRHDESTRELEYRQLHTLQKLRMDLIRLQHQTELENQLEYNKRRERELHRKHVMELRQQPKNLKAMEMQIKKQFQDTCKVQTKQYK
ALKNHQLEVTPKNEHKTILKTLKDEQTRKLAILAEQYEQSINEMMASQALRLDEAQEAECQALRLQLQQEMELLNAYQSKIKMQTEAQHE

--------------------------------------------------------------

>100861_100861_4_ZEB1-TAOK3_ZEB1_chr10_31608221_ENST00000361642_TAOK3_chr12_118651915_ENST00000419821_length(amino acids)=703AA_BP=19
MADGPRCKRRKQANPRRNNAERKPPLFNMNAMSALYHIAQNDSPTLQSNEWTDSFRRFVDYCLQKIPQERPTSAELLRHDFVRRDRPLRV
LIDLIQRTKDAVRELDNLQYRKMKKILFQETRNGPLNESQEDEEDSEHGTSLNREMDSLGSNHSIPSMSVSTGSQSSSVNSMQEVMDESS
SELVMMHDDESTINSSSSVVHKKDHVFIRDEAGHGDPRPEPRPTQSVQSQALHYRNRERFATIKSASLVTRQIHEHEQENELREQMSGYK
RMRRQHQKQLIALENKLKAEMDEHRLKLQKEVETHANNSSIELEKLAKKQVAIIEKEAKVAAADEKKFQQQILAQQKKDLTTFLESQKKQ
YKICKEKIKEEMNEDHSTPKKEKQERISKHKENLQHTQAEEEAHLLTQQRLYYDKNCRFFKRKIMIKRHEVEQQNIREELNKKRTQKEME
HAMLIRHDESTRELEYRQLHTLQKLRMDLIRLQHQTELENQLEYNKRRERELHRKHVMELRQQPKNLKAMEMQIKKQFQDTCKVQTKQYK
ALKNHQLEVTPKNEHKTILKTLKDEQTRKLAILAEQYEQSINEMMASQALRLDEAQEAECQALRLQLQQEMELLNAYQSKIKMQTEAQHE

--------------------------------------------------------------

>100861_100861_5_ZEB1-TAOK3_ZEB1_chr10_31608221_ENST00000542815_TAOK3_chr12_118651915_ENST00000392533_length(amino acids)=703AA_BP=19
MADGPRCKRRKQANPRRNNAERKPPLFNMNAMSALYHIAQNDSPTLQSNEWTDSFRRFVDYCLQKIPQERPTSAELLRHDFVRRDRPLRV
LIDLIQRTKDAVRELDNLQYRKMKKILFQETRNGPLNESQEDEEDSEHGTSLNREMDSLGSNHSIPSMSVSTGSQSSSVNSMQEVMDESS
SELVMMHDDESTINSSSSVVHKKDHVFIRDEAGHGDPRPEPRPTQSVQSQALHYRNRERFATIKSASLVTRQIHEHEQENELREQMSGYK
RMRRQHQKQLIALENKLKAEMDEHRLKLQKEVETHANNSSIELEKLAKKQVAIIEKEAKVAAADEKKFQQQILAQQKKDLTTFLESQKKQ
YKICKEKIKEEMNEDHSTPKKEKQERISKHKENLQHTQAEEEAHLLTQQRLYYDKNCRFFKRKIMIKRHEVEQQNIREELNKKRTQKEME
HAMLIRHDESTRELEYRQLHTLQKLRMDLIRLQHQTELENQLEYNKRRERELHRKHVMELRQQPKNLKAMEMQIKKQFQDTCKVQTKQYK
ALKNHQLEVTPKNEHKTILKTLKDEQTRKLAILAEQYEQSINEMMASQALRLDEAQEAECQALRLQLQQEMELLNAYQSKIKMQTEAQHE

--------------------------------------------------------------

>100861_100861_6_ZEB1-TAOK3_ZEB1_chr10_31608221_ENST00000542815_TAOK3_chr12_118651915_ENST00000419821_length(amino acids)=703AA_BP=19
MADGPRCKRRKQANPRRNNAERKPPLFNMNAMSALYHIAQNDSPTLQSNEWTDSFRRFVDYCLQKIPQERPTSAELLRHDFVRRDRPLRV
LIDLIQRTKDAVRELDNLQYRKMKKILFQETRNGPLNESQEDEEDSEHGTSLNREMDSLGSNHSIPSMSVSTGSQSSSVNSMQEVMDESS
SELVMMHDDESTINSSSSVVHKKDHVFIRDEAGHGDPRPEPRPTQSVQSQALHYRNRERFATIKSASLVTRQIHEHEQENELREQMSGYK
RMRRQHQKQLIALENKLKAEMDEHRLKLQKEVETHANNSSIELEKLAKKQVAIIEKEAKVAAADEKKFQQQILAQQKKDLTTFLESQKKQ
YKICKEKIKEEMNEDHSTPKKEKQERISKHKENLQHTQAEEEAHLLTQQRLYYDKNCRFFKRKIMIKRHEVEQQNIREELNKKRTQKEME
HAMLIRHDESTRELEYRQLHTLQKLRMDLIRLQHQTELENQLEYNKRRERELHRKHVMELRQQPKNLKAMEMQIKKQFQDTCKVQTKQYK
ALKNHQLEVTPKNEHKTILKTLKDEQTRKLAILAEQYEQSINEMMASQALRLDEAQEAECQALRLQLQQEMELLNAYQSKIKMQTEAQHE

--------------------------------------------------------------

>100861_100861_7_ZEB1-TAOK3_ZEB1_chr10_31608221_ENST00000560721_TAOK3_chr12_118651915_ENST00000392533_length(amino acids)=703AA_BP=19
MADGPRCKRRKQANPRRNNAERKPPLFNMNAMSALYHIAQNDSPTLQSNEWTDSFRRFVDYCLQKIPQERPTSAELLRHDFVRRDRPLRV
LIDLIQRTKDAVRELDNLQYRKMKKILFQETRNGPLNESQEDEEDSEHGTSLNREMDSLGSNHSIPSMSVSTGSQSSSVNSMQEVMDESS
SELVMMHDDESTINSSSSVVHKKDHVFIRDEAGHGDPRPEPRPTQSVQSQALHYRNRERFATIKSASLVTRQIHEHEQENELREQMSGYK
RMRRQHQKQLIALENKLKAEMDEHRLKLQKEVETHANNSSIELEKLAKKQVAIIEKEAKVAAADEKKFQQQILAQQKKDLTTFLESQKKQ
YKICKEKIKEEMNEDHSTPKKEKQERISKHKENLQHTQAEEEAHLLTQQRLYYDKNCRFFKRKIMIKRHEVEQQNIREELNKKRTQKEME
HAMLIRHDESTRELEYRQLHTLQKLRMDLIRLQHQTELENQLEYNKRRERELHRKHVMELRQQPKNLKAMEMQIKKQFQDTCKVQTKQYK
ALKNHQLEVTPKNEHKTILKTLKDEQTRKLAILAEQYEQSINEMMASQALRLDEAQEAECQALRLQLQQEMELLNAYQSKIKMQTEAQHE

--------------------------------------------------------------

>100861_100861_8_ZEB1-TAOK3_ZEB1_chr10_31608221_ENST00000560721_TAOK3_chr12_118651915_ENST00000419821_length(amino acids)=703AA_BP=19
MADGPRCKRRKQANPRRNNAERKPPLFNMNAMSALYHIAQNDSPTLQSNEWTDSFRRFVDYCLQKIPQERPTSAELLRHDFVRRDRPLRV
LIDLIQRTKDAVRELDNLQYRKMKKILFQETRNGPLNESQEDEEDSEHGTSLNREMDSLGSNHSIPSMSVSTGSQSSSVNSMQEVMDESS
SELVMMHDDESTINSSSSVVHKKDHVFIRDEAGHGDPRPEPRPTQSVQSQALHYRNRERFATIKSASLVTRQIHEHEQENELREQMSGYK
RMRRQHQKQLIALENKLKAEMDEHRLKLQKEVETHANNSSIELEKLAKKQVAIIEKEAKVAAADEKKFQQQILAQQKKDLTTFLESQKKQ
YKICKEKIKEEMNEDHSTPKKEKQERISKHKENLQHTQAEEEAHLLTQQRLYYDKNCRFFKRKIMIKRHEVEQQNIREELNKKRTQKEME
HAMLIRHDESTRELEYRQLHTLQKLRMDLIRLQHQTELENQLEYNKRRERELHRKHVMELRQQPKNLKAMEMQIKKQFQDTCKVQTKQYK
ALKNHQLEVTPKNEHKTILKTLKDEQTRKLAILAEQYEQSINEMMASQALRLDEAQEAECQALRLQLQQEMELLNAYQSKIKMQTEAQHE

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:31608221/chr12:118651915)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneTAOK3chr10:31608221chr12:118651915ENST00000392533821452_502214.33333333333334899.0Coiled coilOntology_term=ECO:0000255
TgeneTAOK3chr10:31608221chr12:118651915ENST00000392533821548_649214.33333333333334899.0Coiled coilOntology_term=ECO:0000255
TgeneTAOK3chr10:31608221chr12:118651915ENST00000392533821754_879214.33333333333334899.0Coiled coilOntology_term=ECO:0000255
TgeneTAOK3chr10:31608221chr12:118651915ENST00000419821821452_502214.33333333333334899.0Coiled coilOntology_term=ECO:0000255
TgeneTAOK3chr10:31608221chr12:118651915ENST00000419821821548_649214.33333333333334899.0Coiled coilOntology_term=ECO:0000255
TgeneTAOK3chr10:31608221chr12:118651915ENST00000419821821754_879214.33333333333334899.0Coiled coilOntology_term=ECO:0000255
TgeneTAOK3chr10:31608221chr12:118651915ENST00000392533821343_393214.33333333333334899.0Compositional biasNote=Ser-rich
TgeneTAOK3chr10:31608221chr12:118651915ENST00000419821821343_393214.33333333333334899.0Compositional biasNote=Ser-rich

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneZEB1chr10:31608221chr12:118651915ENST00000320985+19989_112419.3333333333333321125.0Compositional biasNote=Glu-rich (acidic)
HgeneZEB1chr10:31608221chr12:118651915ENST00000361642+19989_112419.3333333333333321126.0Compositional biasNote=Glu-rich (acidic)
HgeneZEB1chr10:31608221chr12:118651915ENST00000446923+19989_112401109.0Compositional biasNote=Glu-rich (acidic)
HgeneZEB1chr10:31608221chr12:118651915ENST00000542815+18989_112419.3333333333333321058.0Compositional biasNote=Glu-rich (acidic)
HgeneZEB1chr10:31608221chr12:118651915ENST00000560721+18989_112419.3333333333333321105.0Compositional biasNote=Glu-rich (acidic)
HgeneZEB1chr10:31608221chr12:118651915ENST00000320985+19581_64019.3333333333333321125.0DNA bindingNote=Homeobox%3B atypical
HgeneZEB1chr10:31608221chr12:118651915ENST00000361642+19581_64019.3333333333333321126.0DNA bindingNote=Homeobox%3B atypical
HgeneZEB1chr10:31608221chr12:118651915ENST00000446923+19581_64001109.0DNA bindingNote=Homeobox%3B atypical
HgeneZEB1chr10:31608221chr12:118651915ENST00000542815+18581_64019.3333333333333321058.0DNA bindingNote=Homeobox%3B atypical
HgeneZEB1chr10:31608221chr12:118651915ENST00000560721+18581_64019.3333333333333321105.0DNA bindingNote=Homeobox%3B atypical
HgeneZEB1chr10:31608221chr12:118651915ENST00000320985+19170_19319.3333333333333321125.0Zinc fingerC2H2-type 1
HgeneZEB1chr10:31608221chr12:118651915ENST00000320985+19200_22219.3333333333333321125.0Zinc fingerC2H2-type 2
HgeneZEB1chr10:31608221chr12:118651915ENST00000320985+19240_26219.3333333333333321125.0Zinc fingerC2H2-type 3
HgeneZEB1chr10:31608221chr12:118651915ENST00000320985+19268_29219.3333333333333321125.0Zinc fingerC2H2-type 4%3B atypical
HgeneZEB1chr10:31608221chr12:118651915ENST00000320985+19904_92619.3333333333333321125.0Zinc fingerC2H2-type 5
HgeneZEB1chr10:31608221chr12:118651915ENST00000320985+19932_95419.3333333333333321125.0Zinc fingerC2H2-type 6
HgeneZEB1chr10:31608221chr12:118651915ENST00000320985+19960_98119.3333333333333321125.0Zinc fingerC2H2-type 7%3B atypical
HgeneZEB1chr10:31608221chr12:118651915ENST00000361642+19170_19319.3333333333333321126.0Zinc fingerC2H2-type 1
HgeneZEB1chr10:31608221chr12:118651915ENST00000361642+19200_22219.3333333333333321126.0Zinc fingerC2H2-type 2
HgeneZEB1chr10:31608221chr12:118651915ENST00000361642+19240_26219.3333333333333321126.0Zinc fingerC2H2-type 3
HgeneZEB1chr10:31608221chr12:118651915ENST00000361642+19268_29219.3333333333333321126.0Zinc fingerC2H2-type 4%3B atypical
HgeneZEB1chr10:31608221chr12:118651915ENST00000361642+19904_92619.3333333333333321126.0Zinc fingerC2H2-type 5
HgeneZEB1chr10:31608221chr12:118651915ENST00000361642+19932_95419.3333333333333321126.0Zinc fingerC2H2-type 6
HgeneZEB1chr10:31608221chr12:118651915ENST00000361642+19960_98119.3333333333333321126.0Zinc fingerC2H2-type 7%3B atypical
HgeneZEB1chr10:31608221chr12:118651915ENST00000446923+19170_19301109.0Zinc fingerC2H2-type 1
HgeneZEB1chr10:31608221chr12:118651915ENST00000446923+19200_22201109.0Zinc fingerC2H2-type 2
HgeneZEB1chr10:31608221chr12:118651915ENST00000446923+19240_26201109.0Zinc fingerC2H2-type 3
HgeneZEB1chr10:31608221chr12:118651915ENST00000446923+19268_29201109.0Zinc fingerC2H2-type 4%3B atypical
HgeneZEB1chr10:31608221chr12:118651915ENST00000446923+19904_92601109.0Zinc fingerC2H2-type 5
HgeneZEB1chr10:31608221chr12:118651915ENST00000446923+19932_95401109.0Zinc fingerC2H2-type 6
HgeneZEB1chr10:31608221chr12:118651915ENST00000446923+19960_98101109.0Zinc fingerC2H2-type 7%3B atypical
HgeneZEB1chr10:31608221chr12:118651915ENST00000542815+18170_19319.3333333333333321058.0Zinc fingerC2H2-type 1
HgeneZEB1chr10:31608221chr12:118651915ENST00000542815+18200_22219.3333333333333321058.0Zinc fingerC2H2-type 2
HgeneZEB1chr10:31608221chr12:118651915ENST00000542815+18240_26219.3333333333333321058.0Zinc fingerC2H2-type 3
HgeneZEB1chr10:31608221chr12:118651915ENST00000542815+18268_29219.3333333333333321058.0Zinc fingerC2H2-type 4%3B atypical
HgeneZEB1chr10:31608221chr12:118651915ENST00000542815+18904_92619.3333333333333321058.0Zinc fingerC2H2-type 5
HgeneZEB1chr10:31608221chr12:118651915ENST00000542815+18932_95419.3333333333333321058.0Zinc fingerC2H2-type 6
HgeneZEB1chr10:31608221chr12:118651915ENST00000542815+18960_98119.3333333333333321058.0Zinc fingerC2H2-type 7%3B atypical
HgeneZEB1chr10:31608221chr12:118651915ENST00000560721+18170_19319.3333333333333321105.0Zinc fingerC2H2-type 1
HgeneZEB1chr10:31608221chr12:118651915ENST00000560721+18200_22219.3333333333333321105.0Zinc fingerC2H2-type 2
HgeneZEB1chr10:31608221chr12:118651915ENST00000560721+18240_26219.3333333333333321105.0Zinc fingerC2H2-type 3
HgeneZEB1chr10:31608221chr12:118651915ENST00000560721+18268_29219.3333333333333321105.0Zinc fingerC2H2-type 4%3B atypical
HgeneZEB1chr10:31608221chr12:118651915ENST00000560721+18904_92619.3333333333333321105.0Zinc fingerC2H2-type 5
HgeneZEB1chr10:31608221chr12:118651915ENST00000560721+18932_95419.3333333333333321105.0Zinc fingerC2H2-type 6
HgeneZEB1chr10:31608221chr12:118651915ENST00000560721+18960_98119.3333333333333321105.0Zinc fingerC2H2-type 7%3B atypical
TgeneTAOK3chr10:31608221chr12:118651915ENST0000039253382124_277214.33333333333334899.0DomainProtein kinase
TgeneTAOK3chr10:31608221chr12:118651915ENST0000041982182124_277214.33333333333334899.0DomainProtein kinase
TgeneTAOK3chr10:31608221chr12:118651915ENST0000039253382130_38214.33333333333334899.0Nucleotide bindingATP
TgeneTAOK3chr10:31608221chr12:118651915ENST0000041982182130_38214.33333333333334899.0Nucleotide bindingATP


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
ZEB1
TAOK3


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to ZEB1-TAOK3


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to ZEB1-TAOK3


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource