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Center for Computational Systems Medicine level2
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:ZFHX3-ZMAT4

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: ZFHX3-ZMAT4
FusionPDB ID: 101001
FusionGDB2.0 ID: 101001
HgeneTgene
Gene symbol

ZFHX3

ZMAT4

Gene ID

463

79698

Gene namezinc finger homeobox 3zinc finger matrin-type 4
SynonymsATBF1|ATBT|C16orf47|ZFH-3|ZNF927-
Cytomap

16q22.2-q22.3

8p11.21

Type of geneprotein-codingprotein-coding
Descriptionzinc finger homeobox protein 3AT motif-binding factor 1AT-binding transcription factor 1alpha-fetoprotein enhancer binding proteinzinc finger homeodomain protein 3zinc finger matrin-type protein 4
Modification date2020031320200313
UniProtAcc

Q15911

.
Ensembl transtripts involved in fusion geneENST idsENST00000268489, ENST00000397992, 
ENST00000558842, 		ENST00000523823, 
ENST00000297737, ENST00000315769, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score13 X 13 X 7=118315 X 12 X 7=1260
# samples 1917
** MAII scorelog2(19/1183*10)=-2.63837875000884
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(17/1260*10)=-2.88981708224958
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: ZFHX3 [Title/Abstract] AND ZMAT4 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)ZFHX3(72845476)-ZMAT4(40438780), # samples:3
Anticipated loss of major functional domain due to fusion event.ZFHX3-ZMAT4 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ZFHX3-ZMAT4 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ZFHX3-ZMAT4 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ZFHX3-ZMAT4 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneZFHX3

GO:0000122

negative regulation of transcription by RNA polymerase II

11314020

HgeneZFHX3

GO:0045893

positive regulation of transcription, DNA-templated

20599712

HgeneZFHX3

GO:0071559

response to transforming growth factor beta

20599712


check buttonFusion gene breakpoints across ZFHX3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ZMAT4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-G9-7522-01AZFHX3chr16

72845476

-ZMAT4chr8

40438780

-
ChimerDB4PRADTCGA-G9-7522ZFHX3chr16

72845476

-ZMAT4chr8

40438780

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000268489ZFHX3chr1672845476-ENST00000315769ZMAT4chr840438780-6283453767345421289
ENST00000268489ZFHX3chr1672845476-ENST00000297737ZMAT4chr840438780-6279453767345421289
ENST00000397992ZFHX3chr1672845476-ENST00000315769ZMAT4chr840438780-4060231411382319393
ENST00000397992ZFHX3chr1672845476-ENST00000297737ZMAT4chr840438780-4056231411382319393

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000268489ENST00000315769ZFHX3chr1672845476-ZMAT4chr840438780-0.0034011950.9965988
ENST00000268489ENST00000297737ZFHX3chr1672845476-ZMAT4chr840438780-0.0034144010.9965856
ENST00000397992ENST00000315769ZFHX3chr1672845476-ZMAT4chr840438780-0.0041413750.9958586
ENST00000397992ENST00000297737ZFHX3chr1672845476-ZMAT4chr840438780-0.0041780620.99582195

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>101001_101001_1_ZFHX3-ZMAT4_ZFHX3_chr16_72845476_ENST00000268489_ZMAT4_chr8_40438780_ENST00000297737_length(amino acids)=1289AA_BP=
MEGCDSPVVSGKDNGCGIPQHQQWTELNSTHLPDKPSSMEQSTGESHGPLDSLRAPFNERLAESTASAGPPSEPASKEVTCNECSASFAS
LQTYMEHHCPSARPPPPLREESASDTGEEGDEESDVENLAGEIVYQPDGSAYIVESLSQLTQGGGACGSGSGSGPLPSLFLNSLPGAGGK
QGDPSCAAPVYPQIINTFHIASSFGKWFEGPDQAFPNTSALAGLSPVLHSFRVFDVRHKSNKDYLNSDGSAKSSCVSKDVPNNVDLSKFD
GFVLYGKRKPILMCFLCKLSFGYVRSFVTHAVHDHRMTLSEDERKILSNKNISAIIQGIGKDKEPLVSFLEPKNKNFQHPLVSTANLIGP
GHSFYGKFSGIRMEGEEALPAGSAAGPEQPQAGLLTPSTLLNLGGLTSSVLKTPITSVPLGPLASSPTKSSEGKDSGAAEGEKQEVGDGD
CFSEKVEPAEEEAEEEEEEEEAEEEEEEEEEEEEEEEDEGCKGLFPSELDEELEDRPHEEPGAAAGSSSKKDLALSNQSISNSPLMPNVL
QTLSRGTASTSSNSASSFVVFDGANRRNRLSFNSEGVRANVAEGGRRLDFADESANKDNATAPEPNESTEGDDGGFVPHHQHAGSLCELG
VGECPSGSGVECPKCDTVLGSSRSLGGHMTMMHSRNSCKTLKCPKCNWHYKYQQTLEAHMKEKHPEPGGSCVYCKSGQPHPRLARGESYT
CGYKPFRCEVCNYSTTTKGNLSIHMQSDKHLNNMQNLQNGGGEQVFSHTAGAAAAAVAAAAAAANISSSCGAPSPTKPKTKPTWRCEVCD
YETNVARNLRIHMTSEKHMHNMMLLQQNMTQIQHNRHLGLGSLPSPAEAELYQYYLAQNMNLPNLKMDSAASDAQFMMSGFQLDPAGPMA
AMTPALVGGEIPLDMRLGGGQLVSEELMNLGESFIQTNDPSLKLFQCAVCNKFTTDNLDMLGLHMNVERSLSEDEWKAVMGDSYQCKLCR
YNTQLKANFQLHCKTDKHVQKYQLVAHIKEGGKANEWRLKCVAIGNPVHLKCNACDYYTNSLEKLRLHTVNSRHEASLKLYKHLQQHESG
VEGESCYYHCVLCNYSTKAKLNLIQHVRSMKHQRSESLRKLQRLQKGLPEEDEDLGQIFTIRRCPSTDPEEAIEDVEGPSETAADPEELA
KDQEGGASSSQAEKELTDSPATSKRISFPGSSESPLSSKRPKTAEEIKPEQMYQCPYCKYSNADVNRLRVHAMTQHSVQPMLRCPLCQDM

--------------------------------------------------------------

>101001_101001_2_ZFHX3-ZMAT4_ZFHX3_chr16_72845476_ENST00000268489_ZMAT4_chr8_40438780_ENST00000315769_length(amino acids)=1289AA_BP=
MEGCDSPVVSGKDNGCGIPQHQQWTELNSTHLPDKPSSMEQSTGESHGPLDSLRAPFNERLAESTASAGPPSEPASKEVTCNECSASFAS
LQTYMEHHCPSARPPPPLREESASDTGEEGDEESDVENLAGEIVYQPDGSAYIVESLSQLTQGGGACGSGSGSGPLPSLFLNSLPGAGGK
QGDPSCAAPVYPQIINTFHIASSFGKWFEGPDQAFPNTSALAGLSPVLHSFRVFDVRHKSNKDYLNSDGSAKSSCVSKDVPNNVDLSKFD
GFVLYGKRKPILMCFLCKLSFGYVRSFVTHAVHDHRMTLSEDERKILSNKNISAIIQGIGKDKEPLVSFLEPKNKNFQHPLVSTANLIGP
GHSFYGKFSGIRMEGEEALPAGSAAGPEQPQAGLLTPSTLLNLGGLTSSVLKTPITSVPLGPLASSPTKSSEGKDSGAAEGEKQEVGDGD
CFSEKVEPAEEEAEEEEEEEEAEEEEEEEEEEEEEEEDEGCKGLFPSELDEELEDRPHEEPGAAAGSSSKKDLALSNQSISNSPLMPNVL
QTLSRGTASTSSNSASSFVVFDGANRRNRLSFNSEGVRANVAEGGRRLDFADESANKDNATAPEPNESTEGDDGGFVPHHQHAGSLCELG
VGECPSGSGVECPKCDTVLGSSRSLGGHMTMMHSRNSCKTLKCPKCNWHYKYQQTLEAHMKEKHPEPGGSCVYCKSGQPHPRLARGESYT
CGYKPFRCEVCNYSTTTKGNLSIHMQSDKHLNNMQNLQNGGGEQVFSHTAGAAAAAVAAAAAAANISSSCGAPSPTKPKTKPTWRCEVCD
YETNVARNLRIHMTSEKHMHNMMLLQQNMTQIQHNRHLGLGSLPSPAEAELYQYYLAQNMNLPNLKMDSAASDAQFMMSGFQLDPAGPMA
AMTPALVGGEIPLDMRLGGGQLVSEELMNLGESFIQTNDPSLKLFQCAVCNKFTTDNLDMLGLHMNVERSLSEDEWKAVMGDSYQCKLCR
YNTQLKANFQLHCKTDKHVQKYQLVAHIKEGGKANEWRLKCVAIGNPVHLKCNACDYYTNSLEKLRLHTVNSRHEASLKLYKHLQQHESG
VEGESCYYHCVLCNYSTKAKLNLIQHVRSMKHQRSESLRKLQRLQKGLPEEDEDLGQIFTIRRCPSTDPEEAIEDVEGPSETAADPEELA
KDQEGGASSSQAEKELTDSPATSKRISFPGSSESPLSSKRPKTAEEIKPEQMYQCPYCKYSNADVNRLRVHAMTQHSVQPMLRCPLCQDM

--------------------------------------------------------------

>101001_101001_3_ZFHX3-ZMAT4_ZFHX3_chr16_72845476_ENST00000397992_ZMAT4_chr8_40438780_ENST00000297737_length(amino acids)=393AA_BP=
MQPPPPEKQPLGGEIPLDMRLGGGQLVSEELMNLGESFIQTNDPSLKLFQCAVCNKFTTDNLDMLGLHMNVERSLSEDEWKAVMGDSYQC
KLCRYNTQLKANFQLHCKTDKHVQKYQLVAHIKEGGKANEWRLKCVAIGNPVHLKCNACDYYTNSLEKLRLHTVNSRHEASLKLYKHLQQ
HESGVEGESCYYHCVLCNYSTKAKLNLIQHVRSMKHQRSESLRKLQRLQKGLPEEDEDLGQIFTIRRCPSTDPEEAIEDVEGPSETAADP
EELAKDQEGGASSSQAEKELTDSPATSKRISFPGSSESPLSSKRPKTAEEIKPEQMYQCPYCKYSNADVNRLRVHAMTQHSVQPMLRCPL

--------------------------------------------------------------

>101001_101001_4_ZFHX3-ZMAT4_ZFHX3_chr16_72845476_ENST00000397992_ZMAT4_chr8_40438780_ENST00000315769_length(amino acids)=393AA_BP=
MQPPPPEKQPLGGEIPLDMRLGGGQLVSEELMNLGESFIQTNDPSLKLFQCAVCNKFTTDNLDMLGLHMNVERSLSEDEWKAVMGDSYQC
KLCRYNTQLKANFQLHCKTDKHVQKYQLVAHIKEGGKANEWRLKCVAIGNPVHLKCNACDYYTNSLEKLRLHTVNSRHEASLKLYKHLQQ
HESGVEGESCYYHCVLCNYSTKAKLNLIQHVRSMKHQRSESLRKLQRLQKGLPEEDEDLGQIFTIRRCPSTDPEEAIEDVEGPSETAADP
EELAKDQEGGASSSQAEKELTDSPATSKRISFPGSSESPLSSKRPKTAEEIKPEQMYQCPYCKYSNADVNRLRVHAMTQHSVQPMLRCPL

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr16:72845476/chr8:40438780)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ZFHX3

Q15911

.
FUNCTION: Transcriptional regulator which can act as an activator or a repressor. Inhibits the enhancer element of the AFP gene by binding to its AT-rich core sequence. In concert with SMAD-dependent TGF-beta signaling can repress the transcription of AFP via its interaction with SMAD2/3 (PubMed:25105025). Regulates the circadian locomotor rhythms via transcriptional activation of neuropeptidergic genes which are essential for intercellular synchrony and rhythm amplitude in the suprachiasmatic nucleus (SCN) of the brain (By similarity). Regulator of myoblasts differentiation through the binding to the AT-rich sequence of MYF6 promoter and promoter repression (PubMed:11312261). Down-regulates the MUC5AC promoter in gastric cancer (PubMed:17330845). In association with RUNX3, upregulates CDKN1A promoter activity following TGF-beta stimulation (PubMed:20599712). Inhibits estrogen receptor (ESR1) function by selectively competing with coactivator NCOA3 for binding to ESR1 in ESR1-positive breast cancer cells (PubMed:20720010). {ECO:0000250|UniProtKB:Q61329, ECO:0000269|PubMed:11312261, ECO:0000269|PubMed:17330845, ECO:0000269|PubMed:20599712, ECO:0000269|PubMed:20720010, ECO:0000269|PubMed:25105025}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneZFHX3chr16:72845476chr8:40438780ENST00000268489-710104_1071288.03704.0Compositional biasNote=Poly-Pro
HgeneZFHX3chr16:72845476chr8:40438780ENST00000268489-710460_4891288.03704.0Compositional biasNote=Poly-Glu
HgeneZFHX3chr16:72845476chr8:40438780ENST00000268489-710770_7841288.03704.0Compositional biasNote=Poly-Ala
HgeneZFHX3chr16:72845476chr8:40438780ENST00000397992-69104_107374.02790.0Compositional biasNote=Poly-Pro
HgeneZFHX3chr16:72845476chr8:40438780ENST00000268489-7101040_10641288.03704.0Zinc fingerC2H2-type 9%3B atypical
HgeneZFHX3chr16:72845476chr8:40438780ENST00000268489-7101088_11121288.03704.0Zinc fingerC2H2-type 10%3B atypical
HgeneZFHX3chr16:72845476chr8:40438780ENST00000268489-7101223_12461288.03704.0Zinc fingerC2H2-type 11%3B atypical
HgeneZFHX3chr16:72845476chr8:40438780ENST00000268489-7101252_12751288.03704.0Zinc fingerC2H2-type 12
HgeneZFHX3chr16:72845476chr8:40438780ENST00000268489-710282_3051288.03704.0Zinc fingerC2H2-type 2
HgeneZFHX3chr16:72845476chr8:40438780ENST00000268489-710640_6631288.03704.0Zinc fingerC2H2-type 3
HgeneZFHX3chr16:72845476chr8:40438780ENST00000268489-710671_6941288.03704.0Zinc fingerC2H2-type 4
HgeneZFHX3chr16:72845476chr8:40438780ENST00000268489-710726_7501288.03704.0Zinc fingerC2H2-type 5
HgeneZFHX3chr16:72845476chr8:40438780ENST00000268489-71079_1011288.03704.0Zinc fingerC2H2-type 1%3B degenerate
HgeneZFHX3chr16:72845476chr8:40438780ENST00000268489-710804_8281288.03704.0Zinc fingerC2H2-type 6%3B atypical
HgeneZFHX3chr16:72845476chr8:40438780ENST00000268489-710945_9681288.03704.0Zinc fingerC2H2-type 7%3B degenerate
HgeneZFHX3chr16:72845476chr8:40438780ENST00000268489-710984_10081288.03704.0Zinc fingerC2H2-type 8%3B atypical
HgeneZFHX3chr16:72845476chr8:40438780ENST00000397992-69282_305374.02790.0Zinc fingerC2H2-type 2
HgeneZFHX3chr16:72845476chr8:40438780ENST00000397992-6979_101374.02790.0Zinc fingerC2H2-type 1%3B degenerate
TgeneZMAT4chr16:72845476chr8:40438780ENST0000029773747198_228192.33333333333334230.0Zinc fingerNote=Matrin-type 4
TgeneZMAT4chr16:72845476chr8:40438780ENST0000031576936145_175116.33333333333333154.0Zinc fingerNote=Matrin-type 3
TgeneZMAT4chr16:72845476chr8:40438780ENST0000031576936198_228116.33333333333333154.0Zinc fingerNote=Matrin-type 4

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneZFHX3chr16:72845476chr8:40438780ENST00000268489-7101723_17431288.03704.0Compositional biasNote=Poly-Gln
HgeneZFHX3chr16:72845476chr8:40438780ENST00000268489-7101789_17941288.03704.0Compositional biasNote=Poly-Gln
HgeneZFHX3chr16:72845476chr8:40438780ENST00000268489-7101852_18571288.03704.0Compositional biasNote=Poly-Gln
HgeneZFHX3chr16:72845476chr8:40438780ENST00000268489-7102037_20521288.03704.0Compositional biasNote=Poly-Pro
HgeneZFHX3chr16:72845476chr8:40438780ENST00000268489-7103197_32091288.03704.0Compositional biasNote=Poly-Gln
HgeneZFHX3chr16:72845476chr8:40438780ENST00000268489-7103210_32141288.03704.0Compositional biasNote=Poly-Pro
HgeneZFHX3chr16:72845476chr8:40438780ENST00000268489-7103227_32311288.03704.0Compositional biasNote=Poly-Gln
HgeneZFHX3chr16:72845476chr8:40438780ENST00000268489-7103376_33891288.03704.0Compositional biasNote=Poly-Gln
HgeneZFHX3chr16:72845476chr8:40438780ENST00000268489-7103392_33951288.03704.0Compositional biasNote=Poly-Gln
HgeneZFHX3chr16:72845476chr8:40438780ENST00000268489-7103507_35271288.03704.0Compositional biasNote=Poly-Gly
HgeneZFHX3chr16:72845476chr8:40438780ENST00000268489-7103597_36001288.03704.0Compositional biasNote=Poly-Pro
HgeneZFHX3chr16:72845476chr8:40438780ENST00000268489-7103636_36391288.03704.0Compositional biasNote=Poly-Ser
HgeneZFHX3chr16:72845476chr8:40438780ENST00000397992-691723_1743374.02790.0Compositional biasNote=Poly-Gln
HgeneZFHX3chr16:72845476chr8:40438780ENST00000397992-691789_1794374.02790.0Compositional biasNote=Poly-Gln
HgeneZFHX3chr16:72845476chr8:40438780ENST00000397992-691852_1857374.02790.0Compositional biasNote=Poly-Gln
HgeneZFHX3chr16:72845476chr8:40438780ENST00000397992-692037_2052374.02790.0Compositional biasNote=Poly-Pro
HgeneZFHX3chr16:72845476chr8:40438780ENST00000397992-693197_3209374.02790.0Compositional biasNote=Poly-Gln
HgeneZFHX3chr16:72845476chr8:40438780ENST00000397992-693210_3214374.02790.0Compositional biasNote=Poly-Pro
HgeneZFHX3chr16:72845476chr8:40438780ENST00000397992-693227_3231374.02790.0Compositional biasNote=Poly-Gln
HgeneZFHX3chr16:72845476chr8:40438780ENST00000397992-693376_3389374.02790.0Compositional biasNote=Poly-Gln
HgeneZFHX3chr16:72845476chr8:40438780ENST00000397992-693392_3395374.02790.0Compositional biasNote=Poly-Gln
HgeneZFHX3chr16:72845476chr8:40438780ENST00000397992-693507_3527374.02790.0Compositional biasNote=Poly-Gly
HgeneZFHX3chr16:72845476chr8:40438780ENST00000397992-693597_3600374.02790.0Compositional biasNote=Poly-Pro
HgeneZFHX3chr16:72845476chr8:40438780ENST00000397992-693636_3639374.02790.0Compositional biasNote=Poly-Ser
HgeneZFHX3chr16:72845476chr8:40438780ENST00000397992-69460_489374.02790.0Compositional biasNote=Poly-Glu
HgeneZFHX3chr16:72845476chr8:40438780ENST00000397992-69770_784374.02790.0Compositional biasNote=Poly-Ala
HgeneZFHX3chr16:72845476chr8:40438780ENST00000268489-7102145_22041288.03704.0DNA bindingHomeobox 1
HgeneZFHX3chr16:72845476chr8:40438780ENST00000268489-7102242_23011288.03704.0DNA bindingHomeobox 2
HgeneZFHX3chr16:72845476chr8:40438780ENST00000268489-7102641_27001288.03704.0DNA bindingHomeobox 3
HgeneZFHX3chr16:72845476chr8:40438780ENST00000268489-7102944_30031288.03704.0DNA bindingHomeobox 4
HgeneZFHX3chr16:72845476chr8:40438780ENST00000397992-692145_2204374.02790.0DNA bindingHomeobox 1
HgeneZFHX3chr16:72845476chr8:40438780ENST00000397992-692242_2301374.02790.0DNA bindingHomeobox 2
HgeneZFHX3chr16:72845476chr8:40438780ENST00000397992-692641_2700374.02790.0DNA bindingHomeobox 3
HgeneZFHX3chr16:72845476chr8:40438780ENST00000397992-692944_3003374.02790.0DNA bindingHomeobox 4
HgeneZFHX3chr16:72845476chr8:40438780ENST00000268489-7101360_13851288.03704.0Zinc fingerC2H2-type 13
HgeneZFHX3chr16:72845476chr8:40438780ENST00000268489-7101401_14231288.03704.0Zinc fingerC2H2-type 14
HgeneZFHX3chr16:72845476chr8:40438780ENST00000268489-7101429_14521288.03704.0Zinc fingerC2H2-type 15
HgeneZFHX3chr16:72845476chr8:40438780ENST00000268489-7101545_15691288.03704.0Zinc fingerC2H2-type 16
HgeneZFHX3chr16:72845476chr8:40438780ENST00000268489-7101596_16201288.03704.0Zinc fingerC2H2-type 17
HgeneZFHX3chr16:72845476chr8:40438780ENST00000268489-7101983_20061288.03704.0Zinc fingerC2H2-type 18
HgeneZFHX3chr16:72845476chr8:40438780ENST00000268489-7102328_23511288.03704.0Zinc fingerC2H2-type 19%3B atypical
HgeneZFHX3chr16:72845476chr8:40438780ENST00000268489-7102530_25521288.03704.0Zinc fingerC2H2-type 20
HgeneZFHX3chr16:72845476chr8:40438780ENST00000268489-7102711_27341288.03704.0Zinc fingerC2H2-type 21
HgeneZFHX3chr16:72845476chr8:40438780ENST00000268489-7103024_30481288.03704.0Zinc fingerC2H2-type 22
HgeneZFHX3chr16:72845476chr8:40438780ENST00000268489-7103529_35531288.03704.0Zinc fingerC2H2-type 23
HgeneZFHX3chr16:72845476chr8:40438780ENST00000397992-691040_1064374.02790.0Zinc fingerC2H2-type 9%3B atypical
HgeneZFHX3chr16:72845476chr8:40438780ENST00000397992-691088_1112374.02790.0Zinc fingerC2H2-type 10%3B atypical
HgeneZFHX3chr16:72845476chr8:40438780ENST00000397992-691223_1246374.02790.0Zinc fingerC2H2-type 11%3B atypical
HgeneZFHX3chr16:72845476chr8:40438780ENST00000397992-691252_1275374.02790.0Zinc fingerC2H2-type 12
HgeneZFHX3chr16:72845476chr8:40438780ENST00000397992-691360_1385374.02790.0Zinc fingerC2H2-type 13
HgeneZFHX3chr16:72845476chr8:40438780ENST00000397992-691401_1423374.02790.0Zinc fingerC2H2-type 14
HgeneZFHX3chr16:72845476chr8:40438780ENST00000397992-691429_1452374.02790.0Zinc fingerC2H2-type 15
HgeneZFHX3chr16:72845476chr8:40438780ENST00000397992-691545_1569374.02790.0Zinc fingerC2H2-type 16
HgeneZFHX3chr16:72845476chr8:40438780ENST00000397992-691596_1620374.02790.0Zinc fingerC2H2-type 17
HgeneZFHX3chr16:72845476chr8:40438780ENST00000397992-691983_2006374.02790.0Zinc fingerC2H2-type 18
HgeneZFHX3chr16:72845476chr8:40438780ENST00000397992-692328_2351374.02790.0Zinc fingerC2H2-type 19%3B atypical
HgeneZFHX3chr16:72845476chr8:40438780ENST00000397992-692530_2552374.02790.0Zinc fingerC2H2-type 20
HgeneZFHX3chr16:72845476chr8:40438780ENST00000397992-692711_2734374.02790.0Zinc fingerC2H2-type 21
HgeneZFHX3chr16:72845476chr8:40438780ENST00000397992-693024_3048374.02790.0Zinc fingerC2H2-type 22
HgeneZFHX3chr16:72845476chr8:40438780ENST00000397992-693529_3553374.02790.0Zinc fingerC2H2-type 23
HgeneZFHX3chr16:72845476chr8:40438780ENST00000397992-69640_663374.02790.0Zinc fingerC2H2-type 3
HgeneZFHX3chr16:72845476chr8:40438780ENST00000397992-69671_694374.02790.0Zinc fingerC2H2-type 4
HgeneZFHX3chr16:72845476chr8:40438780ENST00000397992-69726_750374.02790.0Zinc fingerC2H2-type 5
HgeneZFHX3chr16:72845476chr8:40438780ENST00000397992-69804_828374.02790.0Zinc fingerC2H2-type 6%3B atypical
HgeneZFHX3chr16:72845476chr8:40438780ENST00000397992-69945_968374.02790.0Zinc fingerC2H2-type 7%3B degenerate
HgeneZFHX3chr16:72845476chr8:40438780ENST00000397992-69984_1008374.02790.0Zinc fingerC2H2-type 8%3B atypical
TgeneZMAT4chr16:72845476chr8:40438780ENST0000029773747145_175192.33333333333334230.0Zinc fingerNote=Matrin-type 3
TgeneZMAT4chr16:72845476chr8:40438780ENST000002977374714_44192.33333333333334230.0Zinc fingerNote=Matrin-type 1
TgeneZMAT4chr16:72845476chr8:40438780ENST000002977374772_106192.33333333333334230.0Zinc fingerNote=Matrin-type 2
TgeneZMAT4chr16:72845476chr8:40438780ENST000003157693614_44116.33333333333333154.0Zinc fingerNote=Matrin-type 1
TgeneZMAT4chr16:72845476chr8:40438780ENST000003157693672_106116.33333333333333154.0Zinc fingerNote=Matrin-type 2


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
ZFHX3_pLDDT.png
all structure
all structure
ZMAT4_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
ZFHX3
ZMAT4


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to ZFHX3-ZMAT4


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to ZFHX3-ZMAT4


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource