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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:ZMYM4-ACACA

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: ZMYM4-ACACA
FusionPDB ID: 101356
FusionGDB2.0 ID: 101356
HgeneTgene
Gene symbol

ZMYM4

ACACA

Gene ID

9202

31

Gene namezinc finger MYM-type containing 4acetyl-CoA carboxylase alpha
SynonymsCDIR|MYM|ZNF198L3|ZNF262ACAC|ACACAD|ACC|ACC1|ACCA
Cytomap

1p34.3

17q12

Type of geneprotein-codingprotein-coding
Descriptionzinc finger MYM-type protein 4cell death inhibiting RNAzinc finger protein 262zinc finger, MYM-type 4acetyl-CoA carboxylase 1ACC-alphaacetyl-Coenzyme A carboxylase alpha
Modification date2020031320200313
UniProtAcc.

Q13085

Ensembl transtripts involved in fusion geneENST idsENST00000314607, ENST00000373297, 
ENST00000482131, 		ENST00000361253, 
ENST00000416895, ENST00000588142, 
ENST00000589665, ENST00000335166, 
ENST00000353139, ENST00000360679, 
ENST00000394406, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score14 X 8 X 10=112020 X 22 X 7=3080
# samples 1521
** MAII scorelog2(15/1120*10)=-2.90046432644909
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(21/3080*10)=-3.87446911791614
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: ZMYM4 [Title/Abstract] AND ACACA [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)ZMYM4(35734686)-ACACA(35538297), # samples:1
Anticipated loss of major functional domain due to fusion event.ZMYM4-ACACA seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ZMYM4-ACACA seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ZMYM4-ACACA seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ZMYM4-ACACA seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across ZMYM4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ACACA (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-CG-5721-01AZMYM4chr1

35734686

+ACACAchr17

35538297

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000373297ZMYM4chr135734686+ENST00000353139ACACAchr1735538297-4823119802494804
ENST00000373297ZMYM4chr135734686+ENST00000360679ACACAchr1735538297-4817119802494804
ENST00000373297ZMYM4chr135734686+ENST00000394406ACACAchr1735538297-4817119802494804
ENST00000373297ZMYM4chr135734686+ENST00000335166ACACAchr1735538297-2994119802494804
ENST00000314607ZMYM4chr135734686+ENST00000353139ACACAchr1735538297-4823119802494804
ENST00000314607ZMYM4chr135734686+ENST00000360679ACACAchr1735538297-4817119802494804
ENST00000314607ZMYM4chr135734686+ENST00000394406ACACAchr1735538297-4817119802494804
ENST00000314607ZMYM4chr135734686+ENST00000335166ACACAchr1735538297-2994119802494804

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000373297ENST00000353139ZMYM4chr135734686+ACACAchr1735538297-0.0020218890.99797815
ENST00000373297ENST00000360679ZMYM4chr135734686+ACACAchr1735538297-0.0020363210.99796367
ENST00000373297ENST00000394406ZMYM4chr135734686+ACACAchr1735538297-0.0020363210.99796367
ENST00000373297ENST00000335166ZMYM4chr135734686+ACACAchr1735538297-0.0024062810.9975937
ENST00000314607ENST00000353139ZMYM4chr135734686+ACACAchr1735538297-0.0020218890.99797815
ENST00000314607ENST00000360679ZMYM4chr135734686+ACACAchr1735538297-0.0020363210.99796367
ENST00000314607ENST00000394406ZMYM4chr135734686+ACACAchr1735538297-0.0020363210.99796367
ENST00000314607ENST00000335166ZMYM4chr135734686+ACACAchr1735538297-0.0024062810.9975937

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>101356_101356_1_ZMYM4-ACACA_ZMYM4_chr1_35734686_ENST00000314607_ACACA_chr17_35538297_ENST00000335166_length(amino acids)=804AA_BP=13
MAEREVESGPRKRIMFQAYGDKQGPLHGMLINTPYVTKDLLQSKRFQAQSLGTTYIYDIPEMFRQSLIKLWESMSTQAFLPSPPLPSDML
TYTELVLDDQGQLVHMNRLPGGNEIGMVAWKMTFKSPEYPEGRDIIVIGNDITYRIGSFGPQEDLLFLRASELARAEGIPRIYVSANSGA
RIGLAEEIRHMFHVAWVDPEDPYKGYRYLYLTPQDYKRVSALNSVHCEHVEDEGESRYKITDIIGKEEGIGPENLRGSGMIAGESSLAYN
EIITISLVTCRAIGIGAYLVRLGQRTIQVENSHLILTGAGALNKVLGREVYTSNNQLGGIQIMHNNGVTHCTVCDDFEGVFTVLHWLSYM
PKSVHSSVPLLNSKDPIDRIIEFVPTKTPYDPRWMLAGRPHPTQKGQWLSGFFDYGSFSEIMQPWAQTVVVGRARLGGIPVGVVAVETRT
VELSIPADPANLDSEAKIIQQAGQVWFPDSAFKTYQAIKDFNREGLPLMVFANWRGFSGGMKDMYDQVLKFGAYIVDGLRECCQPVLVYI
PPQAELRGGSWVVIDSSINPRHMEMYADRESRGSVLEPEGTVEIKFRRKDLVKTMRRVDPVYIHLAERLGTPELSTAERKELENKLKERE
EFLIPIYHQVAVQFADLHDTPGRMQEKGVISDILDWKTSRTFFYWRLRRLLLEDLVKKKIHNANPELTDGQIQAMLRRWFVEVEGTVKAY

--------------------------------------------------------------

>101356_101356_2_ZMYM4-ACACA_ZMYM4_chr1_35734686_ENST00000314607_ACACA_chr17_35538297_ENST00000353139_length(amino acids)=804AA_BP=13
MAEREVESGPRKRIMFQAYGDKQGPLHGMLINTPYVTKDLLQSKRFQAQSLGTTYIYDIPEMFRQSLIKLWESMSTQAFLPSPPLPSDML
TYTELVLDDQGQLVHMNRLPGGNEIGMVAWKMTFKSPEYPEGRDIIVIGNDITYRIGSFGPQEDLLFLRASELARAEGIPRIYVSANSGA
RIGLAEEIRHMFHVAWVDPEDPYKGYRYLYLTPQDYKRVSALNSVHCEHVEDEGESRYKITDIIGKEEGIGPENLRGSGMIAGESSLAYN
EIITISLVTCRAIGIGAYLVRLGQRTIQVENSHLILTGAGALNKVLGREVYTSNNQLGGIQIMHNNGVTHCTVCDDFEGVFTVLHWLSYM
PKSVHSSVPLLNSKDPIDRIIEFVPTKTPYDPRWMLAGRPHPTQKGQWLSGFFDYGSFSEIMQPWAQTVVVGRARLGGIPVGVVAVETRT
VELSIPADPANLDSEAKIIQQAGQVWFPDSAFKTYQAIKDFNREGLPLMVFANWRGFSGGMKDMYDQVLKFGAYIVDGLRECCQPVLVYI
PPQAELRGGSWVVIDSSINPRHMEMYADRESRGSVLEPEGTVEIKFRRKDLVKTMRRVDPVYIHLAERLGTPELSTAERKELENKLKERE
EFLIPIYHQVAVQFADLHDTPGRMQEKGVISDILDWKTSRTFFYWRLRRLLLEDLVKKKIHNANPELTDGQIQAMLRRWFVEVEGTVKAY

--------------------------------------------------------------

>101356_101356_3_ZMYM4-ACACA_ZMYM4_chr1_35734686_ENST00000314607_ACACA_chr17_35538297_ENST00000360679_length(amino acids)=804AA_BP=13
MAEREVESGPRKRIMFQAYGDKQGPLHGMLINTPYVTKDLLQSKRFQAQSLGTTYIYDIPEMFRQSLIKLWESMSTQAFLPSPPLPSDML
TYTELVLDDQGQLVHMNRLPGGNEIGMVAWKMTFKSPEYPEGRDIIVIGNDITYRIGSFGPQEDLLFLRASELARAEGIPRIYVSANSGA
RIGLAEEIRHMFHVAWVDPEDPYKGYRYLYLTPQDYKRVSALNSVHCEHVEDEGESRYKITDIIGKEEGIGPENLRGSGMIAGESSLAYN
EIITISLVTCRAIGIGAYLVRLGQRTIQVENSHLILTGAGALNKVLGREVYTSNNQLGGIQIMHNNGVTHCTVCDDFEGVFTVLHWLSYM
PKSVHSSVPLLNSKDPIDRIIEFVPTKTPYDPRWMLAGRPHPTQKGQWLSGFFDYGSFSEIMQPWAQTVVVGRARLGGIPVGVVAVETRT
VELSIPADPANLDSEAKIIQQAGQVWFPDSAFKTYQAIKDFNREGLPLMVFANWRGFSGGMKDMYDQVLKFGAYIVDGLRECCQPVLVYI
PPQAELRGGSWVVIDSSINPRHMEMYADRESRGSVLEPEGTVEIKFRRKDLVKTMRRVDPVYIHLAERLGTPELSTAERKELENKLKERE
EFLIPIYHQVAVQFADLHDTPGRMQEKGVISDILDWKTSRTFFYWRLRRLLLEDLVKKKIHNANPELTDGQIQAMLRRWFVEVEGTVKAY

--------------------------------------------------------------

>101356_101356_4_ZMYM4-ACACA_ZMYM4_chr1_35734686_ENST00000314607_ACACA_chr17_35538297_ENST00000394406_length(amino acids)=804AA_BP=13
MAEREVESGPRKRIMFQAYGDKQGPLHGMLINTPYVTKDLLQSKRFQAQSLGTTYIYDIPEMFRQSLIKLWESMSTQAFLPSPPLPSDML
TYTELVLDDQGQLVHMNRLPGGNEIGMVAWKMTFKSPEYPEGRDIIVIGNDITYRIGSFGPQEDLLFLRASELARAEGIPRIYVSANSGA
RIGLAEEIRHMFHVAWVDPEDPYKGYRYLYLTPQDYKRVSALNSVHCEHVEDEGESRYKITDIIGKEEGIGPENLRGSGMIAGESSLAYN
EIITISLVTCRAIGIGAYLVRLGQRTIQVENSHLILTGAGALNKVLGREVYTSNNQLGGIQIMHNNGVTHCTVCDDFEGVFTVLHWLSYM
PKSVHSSVPLLNSKDPIDRIIEFVPTKTPYDPRWMLAGRPHPTQKGQWLSGFFDYGSFSEIMQPWAQTVVVGRARLGGIPVGVVAVETRT
VELSIPADPANLDSEAKIIQQAGQVWFPDSAFKTYQAIKDFNREGLPLMVFANWRGFSGGMKDMYDQVLKFGAYIVDGLRECCQPVLVYI
PPQAELRGGSWVVIDSSINPRHMEMYADRESRGSVLEPEGTVEIKFRRKDLVKTMRRVDPVYIHLAERLGTPELSTAERKELENKLKERE
EFLIPIYHQVAVQFADLHDTPGRMQEKGVISDILDWKTSRTFFYWRLRRLLLEDLVKKKIHNANPELTDGQIQAMLRRWFVEVEGTVKAY

--------------------------------------------------------------

>101356_101356_5_ZMYM4-ACACA_ZMYM4_chr1_35734686_ENST00000373297_ACACA_chr17_35538297_ENST00000335166_length(amino acids)=804AA_BP=13
MAEREVESGPRKRIMFQAYGDKQGPLHGMLINTPYVTKDLLQSKRFQAQSLGTTYIYDIPEMFRQSLIKLWESMSTQAFLPSPPLPSDML
TYTELVLDDQGQLVHMNRLPGGNEIGMVAWKMTFKSPEYPEGRDIIVIGNDITYRIGSFGPQEDLLFLRASELARAEGIPRIYVSANSGA
RIGLAEEIRHMFHVAWVDPEDPYKGYRYLYLTPQDYKRVSALNSVHCEHVEDEGESRYKITDIIGKEEGIGPENLRGSGMIAGESSLAYN
EIITISLVTCRAIGIGAYLVRLGQRTIQVENSHLILTGAGALNKVLGREVYTSNNQLGGIQIMHNNGVTHCTVCDDFEGVFTVLHWLSYM
PKSVHSSVPLLNSKDPIDRIIEFVPTKTPYDPRWMLAGRPHPTQKGQWLSGFFDYGSFSEIMQPWAQTVVVGRARLGGIPVGVVAVETRT
VELSIPADPANLDSEAKIIQQAGQVWFPDSAFKTYQAIKDFNREGLPLMVFANWRGFSGGMKDMYDQVLKFGAYIVDGLRECCQPVLVYI
PPQAELRGGSWVVIDSSINPRHMEMYADRESRGSVLEPEGTVEIKFRRKDLVKTMRRVDPVYIHLAERLGTPELSTAERKELENKLKERE
EFLIPIYHQVAVQFADLHDTPGRMQEKGVISDILDWKTSRTFFYWRLRRLLLEDLVKKKIHNANPELTDGQIQAMLRRWFVEVEGTVKAY

--------------------------------------------------------------

>101356_101356_6_ZMYM4-ACACA_ZMYM4_chr1_35734686_ENST00000373297_ACACA_chr17_35538297_ENST00000353139_length(amino acids)=804AA_BP=13
MAEREVESGPRKRIMFQAYGDKQGPLHGMLINTPYVTKDLLQSKRFQAQSLGTTYIYDIPEMFRQSLIKLWESMSTQAFLPSPPLPSDML
TYTELVLDDQGQLVHMNRLPGGNEIGMVAWKMTFKSPEYPEGRDIIVIGNDITYRIGSFGPQEDLLFLRASELARAEGIPRIYVSANSGA
RIGLAEEIRHMFHVAWVDPEDPYKGYRYLYLTPQDYKRVSALNSVHCEHVEDEGESRYKITDIIGKEEGIGPENLRGSGMIAGESSLAYN
EIITISLVTCRAIGIGAYLVRLGQRTIQVENSHLILTGAGALNKVLGREVYTSNNQLGGIQIMHNNGVTHCTVCDDFEGVFTVLHWLSYM
PKSVHSSVPLLNSKDPIDRIIEFVPTKTPYDPRWMLAGRPHPTQKGQWLSGFFDYGSFSEIMQPWAQTVVVGRARLGGIPVGVVAVETRT
VELSIPADPANLDSEAKIIQQAGQVWFPDSAFKTYQAIKDFNREGLPLMVFANWRGFSGGMKDMYDQVLKFGAYIVDGLRECCQPVLVYI
PPQAELRGGSWVVIDSSINPRHMEMYADRESRGSVLEPEGTVEIKFRRKDLVKTMRRVDPVYIHLAERLGTPELSTAERKELENKLKERE
EFLIPIYHQVAVQFADLHDTPGRMQEKGVISDILDWKTSRTFFYWRLRRLLLEDLVKKKIHNANPELTDGQIQAMLRRWFVEVEGTVKAY

--------------------------------------------------------------

>101356_101356_7_ZMYM4-ACACA_ZMYM4_chr1_35734686_ENST00000373297_ACACA_chr17_35538297_ENST00000360679_length(amino acids)=804AA_BP=13
MAEREVESGPRKRIMFQAYGDKQGPLHGMLINTPYVTKDLLQSKRFQAQSLGTTYIYDIPEMFRQSLIKLWESMSTQAFLPSPPLPSDML
TYTELVLDDQGQLVHMNRLPGGNEIGMVAWKMTFKSPEYPEGRDIIVIGNDITYRIGSFGPQEDLLFLRASELARAEGIPRIYVSANSGA
RIGLAEEIRHMFHVAWVDPEDPYKGYRYLYLTPQDYKRVSALNSVHCEHVEDEGESRYKITDIIGKEEGIGPENLRGSGMIAGESSLAYN
EIITISLVTCRAIGIGAYLVRLGQRTIQVENSHLILTGAGALNKVLGREVYTSNNQLGGIQIMHNNGVTHCTVCDDFEGVFTVLHWLSYM
PKSVHSSVPLLNSKDPIDRIIEFVPTKTPYDPRWMLAGRPHPTQKGQWLSGFFDYGSFSEIMQPWAQTVVVGRARLGGIPVGVVAVETRT
VELSIPADPANLDSEAKIIQQAGQVWFPDSAFKTYQAIKDFNREGLPLMVFANWRGFSGGMKDMYDQVLKFGAYIVDGLRECCQPVLVYI
PPQAELRGGSWVVIDSSINPRHMEMYADRESRGSVLEPEGTVEIKFRRKDLVKTMRRVDPVYIHLAERLGTPELSTAERKELENKLKERE
EFLIPIYHQVAVQFADLHDTPGRMQEKGVISDILDWKTSRTFFYWRLRRLLLEDLVKKKIHNANPELTDGQIQAMLRRWFVEVEGTVKAY

--------------------------------------------------------------

>101356_101356_8_ZMYM4-ACACA_ZMYM4_chr1_35734686_ENST00000373297_ACACA_chr17_35538297_ENST00000394406_length(amino acids)=804AA_BP=13
MAEREVESGPRKRIMFQAYGDKQGPLHGMLINTPYVTKDLLQSKRFQAQSLGTTYIYDIPEMFRQSLIKLWESMSTQAFLPSPPLPSDML
TYTELVLDDQGQLVHMNRLPGGNEIGMVAWKMTFKSPEYPEGRDIIVIGNDITYRIGSFGPQEDLLFLRASELARAEGIPRIYVSANSGA
RIGLAEEIRHMFHVAWVDPEDPYKGYRYLYLTPQDYKRVSALNSVHCEHVEDEGESRYKITDIIGKEEGIGPENLRGSGMIAGESSLAYN
EIITISLVTCRAIGIGAYLVRLGQRTIQVENSHLILTGAGALNKVLGREVYTSNNQLGGIQIMHNNGVTHCTVCDDFEGVFTVLHWLSYM
PKSVHSSVPLLNSKDPIDRIIEFVPTKTPYDPRWMLAGRPHPTQKGQWLSGFFDYGSFSEIMQPWAQTVVVGRARLGGIPVGVVAVETRT
VELSIPADPANLDSEAKIIQQAGQVWFPDSAFKTYQAIKDFNREGLPLMVFANWRGFSGGMKDMYDQVLKFGAYIVDGLRECCQPVLVYI
PPQAELRGGSWVVIDSSINPRHMEMYADRESRGSVLEPEGTVEIKFRRKDLVKTMRRVDPVYIHLAERLGTPELSTAERKELENKLKERE
EFLIPIYHQVAVQFADLHDTPGRMQEKGVISDILDWKTSRTFFYWRLRRLLLEDLVKKKIHNANPELTDGQIQAMLRRWFVEVEGTVKAY

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:35734686/chr17:35538297)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.ACACA

Q13085

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Cytosolic enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the first and rate-limiting step of de novo fatty acid biosynthesis (PubMed:20952656, PubMed:20457939, PubMed:29899443). This is a 2 steps reaction starting with the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain followed by the transfer of the carboxyl group from carboxylated biotin to acetyl-CoA (PubMed:20952656, PubMed:20457939, PubMed:29899443). {ECO:0000269|PubMed:20457939, ECO:0000269|PubMed:20952656, ECO:0000269|PubMed:29899443}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneACACAchr1:35734686chr17:35538297ENST0000033516637551576_19141477.02269.0DomainCoA carboxyltransferase N-terminal
TgeneACACAchr1:35734686chr17:35538297ENST0000033516637551918_22341477.02269.0DomainCoA carboxyltransferase C-terminal
TgeneACACAchr1:35734686chr17:35538297ENST0000035313938561918_22341592.02384.0DomainCoA carboxyltransferase C-terminal
TgeneACACAchr1:35734686chr17:35538297ENST0000036067936541576_19141497.02289.0DomainCoA carboxyltransferase N-terminal
TgeneACACAchr1:35734686chr17:35538297ENST0000036067936541918_22341497.02289.0DomainCoA carboxyltransferase C-terminal
TgeneACACAchr1:35734686chr17:35538297ENST0000039440638561576_19141555.02347.0DomainCoA carboxyltransferase N-terminal
TgeneACACAchr1:35734686chr17:35538297ENST0000039440638561918_22341555.02347.0DomainCoA carboxyltransferase C-terminal
TgeneACACAchr1:35734686chr17:35538297ENST0000033516637551576_22341477.02269.0RegionCarboxyltransferase
TgeneACACAchr1:35734686chr17:35538297ENST0000036067936541576_22341497.02289.0RegionCarboxyltransferase
TgeneACACAchr1:35734686chr17:35538297ENST0000039440638561576_22341555.02347.0RegionCarboxyltransferase

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneZMYM4chr1:35734686chr17:35538297ENST00000314607+130362_40213.01549.0Zinc fingerNote=MYM-type 1
HgeneZMYM4chr1:35734686chr17:35538297ENST00000314607+130414_45713.01549.0Zinc fingerNote=MYM-type 2
HgeneZMYM4chr1:35734686chr17:35538297ENST00000314607+130464_49913.01549.0Zinc fingerNote=MYM-type 3
HgeneZMYM4chr1:35734686chr17:35538297ENST00000314607+130510_54413.01549.0Zinc fingerNote=MYM-type 4
HgeneZMYM4chr1:35734686chr17:35538297ENST00000314607+130554_59213.01549.0Zinc fingerNote=MYM-type 5
HgeneZMYM4chr1:35734686chr17:35538297ENST00000314607+130600_63113.01549.0Zinc fingerNote=MYM-type 6
HgeneZMYM4chr1:35734686chr17:35538297ENST00000314607+130708_74213.01549.0Zinc fingerNote=MYM-type 7
HgeneZMYM4chr1:35734686chr17:35538297ENST00000314607+130749_78813.01549.0Zinc fingerNote=MYM-type 8
HgeneZMYM4chr1:35734686chr17:35538297ENST00000314607+130795_82913.01549.0Zinc fingerNote=MYM-type 9
HgeneZMYM4chr1:35734686chr17:35538297ENST00000373297+128362_40213.01460.0Zinc fingerNote=MYM-type 1
HgeneZMYM4chr1:35734686chr17:35538297ENST00000373297+128414_45713.01460.0Zinc fingerNote=MYM-type 2
HgeneZMYM4chr1:35734686chr17:35538297ENST00000373297+128464_49913.01460.0Zinc fingerNote=MYM-type 3
HgeneZMYM4chr1:35734686chr17:35538297ENST00000373297+128510_54413.01460.0Zinc fingerNote=MYM-type 4
HgeneZMYM4chr1:35734686chr17:35538297ENST00000373297+128554_59213.01460.0Zinc fingerNote=MYM-type 5
HgeneZMYM4chr1:35734686chr17:35538297ENST00000373297+128600_63113.01460.0Zinc fingerNote=MYM-type 6
HgeneZMYM4chr1:35734686chr17:35538297ENST00000373297+128708_74213.01460.0Zinc fingerNote=MYM-type 7
HgeneZMYM4chr1:35734686chr17:35538297ENST00000373297+128749_78813.01460.0Zinc fingerNote=MYM-type 8
HgeneZMYM4chr1:35734686chr17:35538297ENST00000373297+128795_82913.01460.0Zinc fingerNote=MYM-type 9
TgeneACACAchr1:35734686chr17:35538297ENST000003351663755117_6181477.02269.0DomainBiotin carboxylation
TgeneACACAchr1:35734686chr17:35538297ENST000003351663755275_4661477.02269.0DomainATP-grasp
TgeneACACAchr1:35734686chr17:35538297ENST000003351663755745_8191477.02269.0DomainBiotinyl-binding
TgeneACACAchr1:35734686chr17:35538297ENST000003531393856117_6181592.02384.0DomainBiotin carboxylation
TgeneACACAchr1:35734686chr17:35538297ENST0000035313938561576_19141592.02384.0DomainCoA carboxyltransferase N-terminal
TgeneACACAchr1:35734686chr17:35538297ENST000003531393856275_4661592.02384.0DomainATP-grasp
TgeneACACAchr1:35734686chr17:35538297ENST000003531393856745_8191592.02384.0DomainBiotinyl-binding
TgeneACACAchr1:35734686chr17:35538297ENST000003606793654117_6181497.02289.0DomainBiotin carboxylation
TgeneACACAchr1:35734686chr17:35538297ENST000003606793654275_4661497.02289.0DomainATP-grasp
TgeneACACAchr1:35734686chr17:35538297ENST000003606793654745_8191497.02289.0DomainBiotinyl-binding
TgeneACACAchr1:35734686chr17:35538297ENST000003944063856117_6181555.02347.0DomainBiotin carboxylation
TgeneACACAchr1:35734686chr17:35538297ENST000003944063856275_4661555.02347.0DomainATP-grasp
TgeneACACAchr1:35734686chr17:35538297ENST000003944063856745_8191555.02347.0DomainBiotinyl-binding
TgeneACACAchr1:35734686chr17:35538297ENST000003351663755315_3201477.02269.0Nucleotide bindingATP
TgeneACACAchr1:35734686chr17:35538297ENST000003531393856315_3201592.02384.0Nucleotide bindingATP
TgeneACACAchr1:35734686chr17:35538297ENST000003606793654315_3201497.02289.0Nucleotide bindingATP
TgeneACACAchr1:35734686chr17:35538297ENST000003944063856315_3201555.02347.0Nucleotide bindingATP
TgeneACACAchr1:35734686chr17:35538297ENST0000035313938561576_22341592.02384.0RegionCarboxyltransferase


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
ZMYM4
ACACA


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to ZMYM4-ACACA


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to ZMYM4-ACACA


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource