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Center for Computational Systems Medicine level2
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:ZMYND8-GTPBP1

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: ZMYND8-GTPBP1
FusionPDB ID: 101404
FusionGDB2.0 ID: 101404
HgeneTgene
Gene symbol

ZMYND8

GTPBP1

Gene ID

23613

9567

Gene namezinc finger MYND-type containing 8GTP binding protein 1
SynonymsPRKCBP1|PRO2893|RACK7GP-1|GP1|HSPC018
Cytomap

20q13.12

22q13.1

Type of geneprotein-codingprotein-coding
Descriptionprotein kinase C-binding protein 1CTCL tumor antigen se14-3cutaneous T-cell lymphoma-associated antigen se14-3predicted protein of HQ2893zinc finger MYND domain-containing protein 8GTP-binding protein 1G-protein 1
Modification date2020031320200313
UniProtAcc.

A4D1E9

Ensembl transtripts involved in fusion geneENST idsENST00000262975, ENST00000311275, 
ENST00000352431, ENST00000355972, 
ENST00000360911, ENST00000372023, 
ENST00000396281, ENST00000446994, 
ENST00000458360, ENST00000461685, 
ENST00000471951, ENST00000536340, 
ENST00000540497, ENST00000468376, 
ENST00000460605, ENST00000216044, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score25 X 23 X 10=575010 X 10 X 5=500
# samples 3412
** MAII scorelog2(34/5750*10)=-4.0799553045814
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(12/500*10)=-2.05889368905357
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: ZMYND8 [Title/Abstract] AND GTPBP1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)ZMYND8(45848909)-GTPBP1(39111912), # samples:3
Anticipated loss of major functional domain due to fusion event.ZMYND8-GTPBP1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ZMYND8-GTPBP1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ZMYND8-GTPBP1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ZMYND8-GTPBP1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ZMYND8-GTPBP1 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
ZMYND8-GTPBP1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
ZMYND8-GTPBP1 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
ZMYND8-GTPBP1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across ZMYND8 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across GTPBP1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-EW-A1PF-01AZMYND8chr20

45848908

-GTPBP1chr22

39111911

+
ChimerDB4BRCATCGA-EW-A1PF-01AZMYND8chr20

45848909

-GTPBP1chr22

39111912

+
ChimerDB4BRCATCGA-EW-A1PFZMYND8chr20

45848908

-GTPBP1chr22

39111911

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000360911ZMYND8chr2045848909-ENST00000216044GTPBP1chr2239111912+789633073650121658
ENST00000458360ZMYND8chr2045848909-ENST00000216044GTPBP1chr2239111912+766730785047831577
ENST00000471951ZMYND8chr2045848909-ENST00000216044GTPBP1chr2239111912+810035112752161729
ENST00000352431ZMYND8chr2045848909-ENST00000216044GTPBP1chr2239111912+796433752950801683
ENST00000396281ZMYND8chr2045848909-ENST00000216044GTPBP1chr2239111912+8226363721353421709
ENST00000536340ZMYND8chr2045848909-ENST00000216044GTPBP1chr2239111912+817635873152921753
ENST00000540497ZMYND8chr2045848909-ENST00000216044GTPBP1chr2239111912+78573268049731657
ENST00000461685ZMYND8chr2045848909-ENST00000216044GTPBP1chr2239111912+79353346050511683
ENST00000372023ZMYND8chr2045848909-ENST00000216044GTPBP1chr2239111912+77793190048951631
ENST00000360911ZMYND8chr2045848908-ENST00000216044GTPBP1chr2239111911+789633073650121658
ENST00000458360ZMYND8chr2045848908-ENST00000216044GTPBP1chr2239111911+766730785047831577
ENST00000471951ZMYND8chr2045848908-ENST00000216044GTPBP1chr2239111911+810035112752161729
ENST00000352431ZMYND8chr2045848908-ENST00000216044GTPBP1chr2239111911+796433752950801683
ENST00000396281ZMYND8chr2045848908-ENST00000216044GTPBP1chr2239111911+8226363721353421709
ENST00000536340ZMYND8chr2045848908-ENST00000216044GTPBP1chr2239111911+817635873152921753
ENST00000540497ZMYND8chr2045848908-ENST00000216044GTPBP1chr2239111911+78573268049731657
ENST00000461685ZMYND8chr2045848908-ENST00000216044GTPBP1chr2239111911+79353346050511683
ENST00000372023ZMYND8chr2045848908-ENST00000216044GTPBP1chr2239111911+77793190048951631

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000360911ENST00000216044ZMYND8chr2045848909-GTPBP1chr2239111912+0.0015822680.99841774
ENST00000458360ENST00000216044ZMYND8chr2045848909-GTPBP1chr2239111912+0.0010841130.9989159
ENST00000471951ENST00000216044ZMYND8chr2045848909-GTPBP1chr2239111912+0.0011142480.9988858
ENST00000352431ENST00000216044ZMYND8chr2045848909-GTPBP1chr2239111912+0.0016074420.9983925
ENST00000396281ENST00000216044ZMYND8chr2045848909-GTPBP1chr2239111912+0.0013496480.9986504
ENST00000536340ENST00000216044ZMYND8chr2045848909-GTPBP1chr2239111912+0.0012699340.99873
ENST00000540497ENST00000216044ZMYND8chr2045848909-GTPBP1chr2239111912+0.0010446390.99895537
ENST00000461685ENST00000216044ZMYND8chr2045848909-GTPBP1chr2239111912+0.0016331580.9983669
ENST00000372023ENST00000216044ZMYND8chr2045848909-GTPBP1chr2239111912+0.001211220.9987888
ENST00000360911ENST00000216044ZMYND8chr2045848908-GTPBP1chr2239111911+0.0015822680.99841774
ENST00000458360ENST00000216044ZMYND8chr2045848908-GTPBP1chr2239111911+0.0010841130.9989159
ENST00000471951ENST00000216044ZMYND8chr2045848908-GTPBP1chr2239111911+0.0011142480.9988858
ENST00000352431ENST00000216044ZMYND8chr2045848908-GTPBP1chr2239111911+0.0016074420.9983925
ENST00000396281ENST00000216044ZMYND8chr2045848908-GTPBP1chr2239111911+0.0013496480.9986504
ENST00000536340ENST00000216044ZMYND8chr2045848908-GTPBP1chr2239111911+0.0012699340.99873
ENST00000540497ENST00000216044ZMYND8chr2045848908-GTPBP1chr2239111911+0.0010446390.99895537
ENST00000461685ENST00000216044ZMYND8chr2045848908-GTPBP1chr2239111911+0.0016331580.9983669
ENST00000372023ENST00000216044ZMYND8chr2045848908-GTPBP1chr2239111911+0.001211220.9987888

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>101404_101404_1_ZMYND8-GTPBP1_ZMYND8_chr20_45848908_ENST00000352431_GTPBP1_chr22_39111911_ENST00000216044_length(amino acids)=1683AA_BP=1115
MHPQSLAEEEIKTEQEVVEGMDISTRSKDPGSAERTAQKRKFPSPPHSSNGHSPQDTSTSPIKKKKKPGLLNSNNKEQSELRHGPFYYMK
QPLTTDPVDVVPQDGRNDFYCWVCHREGQVLCCELCPRVYHAKCLRLTSEPEGDWFCPECEKITVAECIETQSKAMTMLTIEQLSYLLKF
AIQKMKQPGTDAFQKPVPLEQHPDYAEYIFHPMDLCTLEKNAKKKMYGCTEAFLADAKWILHNCIIYNGGNHKLTQIAKVVIKICEHEMN
EIEVCPECYLAACQKRDNWFCEPCSNPHPLVWAKLKGFPFWPAKALRDKDGQVDARFFGQHDRAWVPINNCYLMSKEIPFSVKKTKSIFN
SAMQEMEVYVENIRRKFGVFNYSPFRTPYTPNSQYQMLLDPTNPSAGTAKIDKQEKVKLNFDMTASPKILMSKPVLSGGTGRRISLSDMP
RSPMSTNSSVHTGSDVEQDAEKKATSSHFSASEESMDFLDKSTASPASTKTGQAGSLSGSPKPFSPQLSAPITTKTDKTSTTGSILNLNL
DRSKAEMDLKELSESVQQQSTPVPLISPKRQIRSRFQLNLDKTIESCKAQLGINEISEDVYTAVEHSDSEDSEKSDSSDSEYISDDEQKS
KNEPEDTEDKEGCQMDKEPSAVKKKPKPTNPVEIKEELKSTSPASEKADPGAVKDKASPEPEKDFSEKAKPSPHPIKDKLKGKDETDSPT
VHLGLDSDSESELVIDLGEDHSGREGRKNKKEPKEPSPKQDVVGKTPPSTTVGSHSPPETPVLTRSSAQTSAAGATATTSTSSTVTVTAP
APAATGSPVKKQRPLLPKETAPAVQRVVWNSSTVQQKEITQSPSTSTITLVTSTQSSPLVTSSGSMSTLVSSVNADLPIATASADVAADI
AKYTSKMMDAIKGTMTEIYNDLSKNTTGSTIAEIRRLRIEIEKLQWLHQQELSEMKHNLELTMAEMRQSLEQERDRLIAEVKKQLELEKQ
QAVDETKKKQWCANCKKEAIFYCCWNTSYCDYPCQQAHWPEHMKSCTQSATAPQQEADAEVNTETLNKSSQGSSSSTQSAPSETASASKE
KETSAEKSKESGSTLDLSGSRETPSSILLGSNQGSDGTEYGLSEADMEASYATVKSMAEQIEADVILLRERQEAGGRVRDYLVRKRVGDN
DFLEVRVAVVGNVDAGKSTLLGVLTHGELDNGRGFARQKLFRHKHEIESGRTSSVGNDILGFDSEGNVVNKPDSHGGSLEWTKICEKSTK
VITFIDLAGHEKYLKTTVFGMTGHLPDFCMLMVGSNAGIVGMTKEHLGLALALNVPVFVVVTKIDMCPANILQETLKLLQRLLKSPGCRK
IPVLVQSKDDVIVTASNFSSERMCPIFQISNVTGENLDLLKMFLNLLSPRTSYREEEPAEFQIDDTYSVPGVGTVVSGTTLRGLIKLNDT
LLLGPDPLGNFLSIAVKSIHRKRMPVKEVRGGQTASFALKKIKRSSIRKGMVMVSPRLNPQASWEFEAEILVLHHPTTISPRYQAMVHCG
SIRQTATILSMDKDCLRTGDKATVHFRFIKTPEYLHIDQRLVFREGRTKAVGTITKLLQTTNNSPMNSKPQQIKMQSTKKGPLTKRDEGG

--------------------------------------------------------------

>101404_101404_2_ZMYND8-GTPBP1_ZMYND8_chr20_45848908_ENST00000360911_GTPBP1_chr22_39111911_ENST00000216044_length(amino acids)=1658AA_BP=1090
MHPQSLAEEEIKTEQEVVEGMDISTRSKDPGSAERTAQKRKFPSPPHSSNGHSPQDTSTSPIKKKKKPGLLNSNNKEQDGRNDFYCWVCH
REGQVLCCELCPRVYHAKCLRLTSEPEGDWFCPECEKITVAECIETQSKAMTMLTIEQLSYLLKFAIQKMKQPGTDAFQKPVPLEQHPDY
AEYIFHPMDLCTLEKNAKKKMYGCTEAFLADAKWILHNCIIYNGGNHKLTQIAKVVIKICEHEMNEIEVCPECYLAACQKRDNWFCEPCS
NPHPLVWAKLKGFPFWPAKALRDKDGQVDARFFGQHDRAWVPINNCYLMSKEIPFSVKKTKSIFNSAMQEMEVYVENIRRKFGVFNYSPF
RTPYTPNSQYQMLLDPTNPSAGTAKIDKQEKVKLNFDMTASPKILMSKPVLSGGTGRRISLSDMPRSPMSTNSSVHTGSDVEQDAEKKAT
SSHFSASEESMDFLDKSTASPASTKTGQAGSLSGSPKPFSPQLSAPITTKTDKTSTTGSILNLNLDRSKAEMDLKELSESVQQQSTPVPL
ISPKRQIRSRFQLNLDKTIESCKAQLGINEISEDVYTAVEHSDSEDSEKSDSSDSEYISDDEQKSKNEPEDTEDKEGCQMDKEPSAVKKK
PKPTNPVEIKEELKSTSPASEKADPGAVKDKASPEPEKDFSEKAKPSPHPIKDKLKGKDETDSPTVHLGLDSDSESELVIDLGEDHSGRE
GRKNKKEPKEPSPKQDVVGKTPPSTTVGSHSPPETPVLTRSSAQTSAAGATATTSTSSTVTVTAPAPAATGSPVKKQRPLLPKETAPAVQ
RVVWNSSTVQQKEITQSPSTSTITLVTSTQSSPLVTSSGSMSTLVSSVNADLPIATASADVAADIAKYTSKMMDAIKGTMTEIYNDLSKN
TTGSTIAEIRRLRIEIEKLQWLHQQELSEMKHNLELTMAEMRQSLEQERDRLIAEVKKQLELEKQQAVDETKKKQWCANCKKEAIFYCCW
NTSYCDYPCQQAHWPEHMKSCTQSATAPQQEADAEVNTETLNKSSQGSSSSTQSAPSETASASKEKETSAEKSKESGSTLDLSGSRETPS
SILLGSNQGSDGTEYGLSEADMEASYATVKSMAEQIEADVILLRERQEAGGRVRDYLVRKRVGDNDFLEVRVAVVGNVDAGKSTLLGVLT
HGELDNGRGFARQKLFRHKHEIESGRTSSVGNDILGFDSEGNVVNKPDSHGGSLEWTKICEKSTKVITFIDLAGHEKYLKTTVFGMTGHL
PDFCMLMVGSNAGIVGMTKEHLGLALALNVPVFVVVTKIDMCPANILQETLKLLQRLLKSPGCRKIPVLVQSKDDVIVTASNFSSERMCP
IFQISNVTGENLDLLKMFLNLLSPRTSYREEEPAEFQIDDTYSVPGVGTVVSGTTLRGLIKLNDTLLLGPDPLGNFLSIAVKSIHRKRMP
VKEVRGGQTASFALKKIKRSSIRKGMVMVSPRLNPQASWEFEAEILVLHHPTTISPRYQAMVHCGSIRQTATILSMDKDCLRTGDKATVH
FRFIKTPEYLHIDQRLVFREGRTKAVGTITKLLQTTNNSPMNSKPQQIKMQSTKKGPLTKRDEGGPSGGPAVGAPPPGDEASSVGAGQPA

--------------------------------------------------------------

>101404_101404_3_ZMYND8-GTPBP1_ZMYND8_chr20_45848908_ENST00000372023_GTPBP1_chr22_39111911_ENST00000216044_length(amino acids)=1631AA_BP=1063
MHPQSLAEEEIKTEQEVVEGMDISTRSKDPGSAERTAQKRKFPSPPHSSNGHSPQDTSTSPIKKKKKPGLLNSNNKEQDGRNDFYCWVCH
REGQVLCCELCPRVYHAKCLRLTSEPEGDWFCPECEKITVAECIETQSKAMTMLTIEQLSYLLKFAIQKMKQPGTDAFQKPVPLEQHPDY
AEYIFHPMDLCTLEKNAKKKMYGCTEAFLADAKWILHNCIIYNGGNHKLTQIAKVVIKICEHEMNEIEVCPECYLAACQKRDNWFCEPCS
NPHPLVWAKLKGFPFWPAKALRDKDGQVDARFFGQHDRAWVPINNCYLMSKEIPFSVKKTKSIFNSAMQEMEVYVENIRRKFGVFNYSPF
RTPYTPNSQYQMLLDPTNPSAGTAKIDKQEKVKLNFDMTASPKILMSKPVLSGGTGRRISLSDMPRSPMSTNSSVHTGSDVEQDAEKKAT
SSHFSASEESMDFLDKSTASPASTKTGQAGSLSGSPKPFSPQLSAPITTKTDKTSTTGSILNLNLDRSKAEMDLKELSESVQQQSTPVPL
ISPKRQIRSRFQLNLDKTIESCKAQLGINEISEDVYTAVEHSDSEDSEKSDSSDSEYISDDEQKSKNEPEDTEDKEGCQMDKEPSAVKKK
PKPTNPVEIKEELKSTSPASEKADPGAVKDKASPEPEKDFSEKAKPSPHPIKDKLKGKDETDSPTVHLGLDSDSESELVIDLGEDHSGRE
GRKNKKEPKEPSPKQDVVGKTPPSTTVGSHSPPETPVLTRSSAQTSAAGATATTSTSSTVTVTAPAPAATGSPVKKQRPLLPKETAPAVQ
RVVWNSSTVQQKEITQSPSTSTITLVTSTQSSPLVTSSGSMSTLVSSVNADLPIATASADVAADIAKYTSKIRRLRIEIEKLQWLHQQEL
SEMKHNLELTMAEMRQSLEQERDRLIAEVKKQLELEKQQAVDETKKKQWCANCKKEAIFYCCWNTSYCDYPCQQAHWPEHMKSCTQSATA
PQQEADAEVNTETLNKSSQGSSSSTQSAPSETASASKEKETSAEKSKESGSTLDLSGSRETPSSILLGSNQGSDGTEYGLSEADMEASYA
TVKSMAEQIEADVILLRERQEAGGRVRDYLVRKRVGDNDFLEVRVAVVGNVDAGKSTLLGVLTHGELDNGRGFARQKLFRHKHEIESGRT
SSVGNDILGFDSEGNVVNKPDSHGGSLEWTKICEKSTKVITFIDLAGHEKYLKTTVFGMTGHLPDFCMLMVGSNAGIVGMTKEHLGLALA
LNVPVFVVVTKIDMCPANILQETLKLLQRLLKSPGCRKIPVLVQSKDDVIVTASNFSSERMCPIFQISNVTGENLDLLKMFLNLLSPRTS
YREEEPAEFQIDDTYSVPGVGTVVSGTTLRGLIKLNDTLLLGPDPLGNFLSIAVKSIHRKRMPVKEVRGGQTASFALKKIKRSSIRKGMV
MVSPRLNPQASWEFEAEILVLHHPTTISPRYQAMVHCGSIRQTATILSMDKDCLRTGDKATVHFRFIKTPEYLHIDQRLVFREGRTKAVG
TITKLLQTTNNSPMNSKPQQIKMQSTKKGPLTKRDEGGPSGGPAVGAPPPGDEASSVGAGQPAASSNLQPQPKPSSGGRRRGGQRHKVKS

--------------------------------------------------------------

>101404_101404_4_ZMYND8-GTPBP1_ZMYND8_chr20_45848908_ENST00000396281_GTPBP1_chr22_39111911_ENST00000216044_length(amino acids)=1709AA_BP=1141
MFSSLQKSFNLAEEEIKTEQEVVEGMDISTRSKDPGSAERTAQKRKFPSPPHSSNGHSPQDTSTSPIKKKKKPGLLNSNNKEQDGRNDFY
CWVCHREGQVLCCELCPRVYHAKCLRLTSEPEGDWFCPECEKITVAECIETQSKAMTMLTIEQLSYLLKFAIQKMKQPGTDAFQKPVPLE
QHPDYAEYIFHPMDLCTLEKNAKKKMYGCTEAFLADAKWILHNCIIYNGGNHKLTQIAKVVIKICEHEMNEIEVCPECYLAACQKRDNWF
CEPCSNPHPLVWAKLKGFPFWPAKALRDKDGQVDARFFGQHDRAWVPINNCYLMSKEIPFSVKKTKSIFNSAMQEMEVYVENIRRKFGVF
NYSPFRTPYTPNSQYQMLLDPTNPSAGTAKIDKQEKVKLNFDMTASPKILMSKPVLSGGTGRRISLSDMPRSPMSTNSSVHTGSDVEQDA
EKKATSSHFSASEESMDFLDKSTASPASTKTGQAGSLSGSPKPFSPQLSAPITTKTDKTSTTGSILNLNLDRSKAEMDLKELSESVQQQS
TPVPLISPKRQIRSRFQLNLDKTIESCKAQLGINEISEDVYTAVEHSDSEDSEKSDSSDSEYISDDEQKSKNEPEDTEDKEGCQMDKEPS
AVKKKPKPTNPVEIKEELKSTSPASEKADPGAVKDKASPEPEKDFSEKAKPSPHPIKDKLKGKDETDSPTVHLGLDSDSESELVIDLGED
HSGREGRKNKKEPKEPSPKQDVVGKTPPSTTVGSHSPPETPVLTRSSAQTSAAGATATTSTSSTVTVTAPAPAATGSPVKKQRPLLPKET
APAVQRVVWNSSSKFQTSSQKWHMQKMQRQQQQQQQQNQQQQPQSSQGTRYQTRQAVKAVQQKEITQSPSTSTITLVTSTQSSPLVTSSG
SMSTLVSSVNADLPIATASADVAADIAKYTSKMMDAIKGTMTEIYNDLSKNTTGSTIAEIRRLRIEIEKLQWLHQQELSEMKHNLELTMA
EMRQSLEQERDRLIAEVKKQLELEKQQAVDETKKKQWCANCKKEAIFYCCWNTSYCDYPCQQAHWPEHMKSCTQSATAPQQEADAEVNTE
TLNKSSQGSSSSTQSAPSETASASKEKETSAEKSKESGSTLDLSGSRETPSSILLGSNQGSDGTEYGLSEADMEASYATVKSMAEQIEAD
VILLRERQEAGGRVRDYLVRKRVGDNDFLEVRVAVVGNVDAGKSTLLGVLTHGELDNGRGFARQKLFRHKHEIESGRTSSVGNDILGFDS
EGNVVNKPDSHGGSLEWTKICEKSTKVITFIDLAGHEKYLKTTVFGMTGHLPDFCMLMVGSNAGIVGMTKEHLGLALALNVPVFVVVTKI
DMCPANILQETLKLLQRLLKSPGCRKIPVLVQSKDDVIVTASNFSSERMCPIFQISNVTGENLDLLKMFLNLLSPRTSYREEEPAEFQID
DTYSVPGVGTVVSGTTLRGLIKLNDTLLLGPDPLGNFLSIAVKSIHRKRMPVKEVRGGQTASFALKKIKRSSIRKGMVMVSPRLNPQASW
EFEAEILVLHHPTTISPRYQAMVHCGSIRQTATILSMDKDCLRTGDKATVHFRFIKTPEYLHIDQRLVFREGRTKAVGTITKLLQTTNNS

--------------------------------------------------------------

>101404_101404_5_ZMYND8-GTPBP1_ZMYND8_chr20_45848908_ENST00000458360_GTPBP1_chr22_39111911_ENST00000216044_length(amino acids)=1577AA_BP=1009
MHPQSLAEEEIKTEQEVVEGMDISTRSKDPGSAERTAQKRKFPSPPHSSNGHSPQDTSTSPIKKKKKPGLLNSNNKEQDGRNDFYCWVCH
REGQVLCCELCPRVYHAKCLRLTSEPEGDWFCPECEKITVAECIETQSKAMTMLTIEQLSYLLKFAIQKMKQPGTDAFQKPVPLEQHPDY
AEYIFHPMDLCTLEKNAKKKMYGCTEAFLADAKWILHNCIIYNGGNHKLTQIAKVVIKICEHEMNEIEVCPECYLAACQKRDNWFCEPCS
NPHPLVWAKLKGFPFWPAKALRDKDGQVDARFFGQHDRAWVPINNCYLMSKEIPFSVKKTKSIFNSAMQEMEVYVENIRRKFGVFNYSPF
RTPYTPNSQYQMLLDPTNPSAGTAKIDKQEKVKLNFDMTASPKILMSKPVLSGGTGRRISLSDMPRSPMSTNSSVHTGSDVEQDAEKKAT
SSHFSASEESMDFLDKSTASPASTKTGQAGSLSGSPKPFSPQLSAPITTKTDKTSTTGSILNLNLDRSKAEMDLKELSESVQQQSTPVPL
ISPKRQIRSRFQLNLDKTIESCKAQLGINEISEDVYTAVEHSDSEDSEKSDSSDSEYISDDEQKSKNEPEDTEDKEGCQMDKEPSAVKKK
PKPTNPVEIKEELKSTSPASEKADPGAVKDKASPEPEKDFSEKAKPSPHPIKDKLKGKDETDSPTVHLGLDSDSESELVIDLGEDHSGRE
GRKNKKEPKEPSPKQDAVQQKEITQSPSTSTITLVTSTQSSPLVTSSGSMSTLVSSVNADLPIATASADVAADIAKYTSKMMDAIKGTMT
EIYNDLSKNTTGSTIAEIRRLRIEIEKLQWLHQQELSEMKHNLELTMAEMRQSLEQERDRLIAEVKKQLELEKQQAVDETKKKQWCANCK
KEAIFYCCWNTSYCDYPCQQAHWPEHMKSCTQSATAPQQEADAEVNTETLNKSSQGSSSSTQSAPSETASASKEKETSAEKSKESGSTLD
LSGSRETPSSILLGSNQGSDGTEYGLSEADMEASYATVKSMAEQIEADVILLRERQEAGGRVRDYLVRKRVGDNDFLEVRVAVVGNVDAG
KSTLLGVLTHGELDNGRGFARQKLFRHKHEIESGRTSSVGNDILGFDSEGNVVNKPDSHGGSLEWTKICEKSTKVITFIDLAGHEKYLKT
TVFGMTGHLPDFCMLMVGSNAGIVGMTKEHLGLALALNVPVFVVVTKIDMCPANILQETLKLLQRLLKSPGCRKIPVLVQSKDDVIVTAS
NFSSERMCPIFQISNVTGENLDLLKMFLNLLSPRTSYREEEPAEFQIDDTYSVPGVGTVVSGTTLRGLIKLNDTLLLGPDPLGNFLSIAV
KSIHRKRMPVKEVRGGQTASFALKKIKRSSIRKGMVMVSPRLNPQASWEFEAEILVLHHPTTISPRYQAMVHCGSIRQTATILSMDKDCL
RTGDKATVHFRFIKTPEYLHIDQRLVFREGRTKAVGTITKLLQTTNNSPMNSKPQQIKMQSTKKGPLTKRDEGGPSGGPAVGAPPPGDEA

--------------------------------------------------------------

>101404_101404_6_ZMYND8-GTPBP1_ZMYND8_chr20_45848908_ENST00000461685_GTPBP1_chr22_39111911_ENST00000216044_length(amino acids)=1683AA_BP=1115
MHPQSLAEEEIKTEQEVVEGMDISTRSKDPGSAERTAQKRKFPSPPHSSNGHSPQDTSTSPIKKKKKPGLLNSNNKEQSELRHGPFYYMK
QPLTTDPVDVVPQDGRNDFYCWVCHREGQVLCCELCPRVYHAKCLRLTSEPEGDWFCPECEKITVAECIETQSKAMTMLTIEQLSYLLKF
AIQKMKQPGTDAFQKPVPLEQHPDYAEYIFHPMDLCTLEKNAKKKMYGCTEAFLADAKWILHNCIIYNGGNHKLTQIAKVVIKICEHEMN
EIEVCPECYLAACQKRDNWFCEPCSNPHPLVWAKLKGFPFWPAKALRDKDGQVDARFFGQHDRAWVPINNCYLMSKEIPFSVKKTKSIFN
SAMQEMEVYVENIRRKFGVFNYSPFRTPYTPNSQYQMLLDPTNPSAGTAKIDKQEKVKLNFDMTASPKILMSKPVLSGGTGRRISLSDMP
RSPMSTNSSVHTGSDVEQDAEKKATSSHFSASEESMDFLDKSTASPASTKTGQAGSLSGSPKPFSPQLSAPITTKTDKTSTTGSILNLNL
DRSKAEMDLKELSESVQQQSTPVPLISPKRQIRSRFQLNLDKTIESCKAQLGINEISEDVYTAVEHSDSEDSEKSDSSDSEYISDDEQKS
KNEPEDTEDKEGCQMDKEPSAVKKKPKPTNPVEIKEELKSTSPASEKADPGAVKDKASPEPEKDFSEKAKPSPHPIKDKLKGKDETDSPT
VHLGLDSDSESELVIDLGEDHSGREGRKNKKEPKEPSPKQDVVGKTPPSTTVGSHSPPETPVLTRSSAQTSAAGATATTSTSSTVTVTAP
APAATGSPVKKQRPLLPKETAPAVQRVVWNSSTVQQKEITQSPSTSTITLVTSTQSSPLVTSSGSMSTLVSSVNADLPIATASADVAADI
AKYTSKMMDAIKGTMTEIYNDLSKNTTGSTIAEIRRLRIEIEKLQWLHQQELSEMKHNLELTMAEMRQSLEQERDRLIAEVKKQLELEKQ
QAVDETKKKQWCANCKKEAIFYCCWNTSYCDYPCQQAHWPEHMKSCTQSATAPQQEADAEVNTETLNKSSQGSSSSTQSAPSETASASKE
KETSAEKSKESGSTLDLSGSRETPSSILLGSNQGSDGTEYGLSEADMEASYATVKSMAEQIEADVILLRERQEAGGRVRDYLVRKRVGDN
DFLEVRVAVVGNVDAGKSTLLGVLTHGELDNGRGFARQKLFRHKHEIESGRTSSVGNDILGFDSEGNVVNKPDSHGGSLEWTKICEKSTK
VITFIDLAGHEKYLKTTVFGMTGHLPDFCMLMVGSNAGIVGMTKEHLGLALALNVPVFVVVTKIDMCPANILQETLKLLQRLLKSPGCRK
IPVLVQSKDDVIVTASNFSSERMCPIFQISNVTGENLDLLKMFLNLLSPRTSYREEEPAEFQIDDTYSVPGVGTVVSGTTLRGLIKLNDT
LLLGPDPLGNFLSIAVKSIHRKRMPVKEVRGGQTASFALKKIKRSSIRKGMVMVSPRLNPQASWEFEAEILVLHHPTTISPRYQAMVHCG
SIRQTATILSMDKDCLRTGDKATVHFRFIKTPEYLHIDQRLVFREGRTKAVGTITKLLQTTNNSPMNSKPQQIKMQSTKKGPLTKRDEGG

--------------------------------------------------------------

>101404_101404_7_ZMYND8-GTPBP1_ZMYND8_chr20_45848908_ENST00000471951_GTPBP1_chr22_39111911_ENST00000216044_length(amino acids)=1729AA_BP=1161
MHPQSLAEEEIKTEQEVVEGMDISTRSKDPGSAERTAQKRKFPSPPHSSNGHSPQDTSTSPIKKKKKPGLLNSNNKEQSELRHGPFYYMK
QPLTTDPVDVVPQDGRNDFYCWVCHREGQVLCCELCPRVYHAKCLRLTSEPEGDWFCPECEKITVAECIETQSKAMTMLTIEQLSYLLKF
AIQKMKQPGTDAFQKPVPLEQHPDYAEYIFHPMDLCTLEKNAKKKMYGCTEAFLADAKWILHNCIIYNGGNHKLTQIAKVVIKICEHEMN
EIEVCPECYLAACQKRDNWFCEPCSNPHPLVWAKLKGFPFWPAKALRDKDGQVDARFFGQHDRAWVPINNCYLMSKEIPFSVKKTKSIFN
SAMQEMEVYVENIRRKFGVFNYSPFRTPYTPNSQYQMLLDPTNPSAGTAKIDKQEKVKLNFDMTASPKILMSKPVLSGGTGRRISLSDMP
RSPMSTNSSVHTGSDVEQDAEKKATSSHFSASEESMDFLDKSTASPASTKTGQAGSLSGSPKPFSPQLSAPITTKTDKTSTTGSILNLNL
DRSKAEMDLKELSESVQQQSTPVPLISPKRQIRSRFQLNLDKTIESCKAQLGINEISEDVYTAVEHSDSEDSEKSDSSDSEYISDDEQKS
KNEPEDTEDKEGCQMDKEPSAVKKKPKPTNPVEIKEELKSTSPASEKADPGAVKDKASPEPEKDFSEKAKPSPHPIKDKLKGKDETDSPT
VHLGLDSDSESELVIDLGEDHSGREGRKNKKEPKEPSPKQDVVGKTPPSTTVGSHSPPETPVLTRSSAQTSAAGATATTSTSSTVTVTAP
APAATGSPVKKQRPLLPKETAPAVQRVVWNSSSKFQTSSQKWHMQKMQRQQQQQQQQNQQQQPQSSQGTRYQTRQAVKAVQQKEITQSPS
TSTITLVTSTQSSPLVTSSGSMSTLVSSVNADLPIATASADVAADIAKYTSKMMDAIKGTMTEIYNDLSKNTTGSTIAEIRRLRIEIEKL
QWLHQQELSEMKHNLELTMAEMRQSLEQERDRLIAEVKKQLELEKQQAVDETKKKQWCANCKKEAIFYCCWNTSYCDYPCQQAHWPEHMK
SCTQSATAPQQEADAEVNTETLNKSSQGSSSSTQSAPSETASASKEKETSAEKSKESGSTLDLSGSRETPSSILLGSNQGSDGTEYGLSE
ADMEASYATVKSMAEQIEADVILLRERQEAGGRVRDYLVRKRVGDNDFLEVRVAVVGNVDAGKSTLLGVLTHGELDNGRGFARQKLFRHK
HEIESGRTSSVGNDILGFDSEGNVVNKPDSHGGSLEWTKICEKSTKVITFIDLAGHEKYLKTTVFGMTGHLPDFCMLMVGSNAGIVGMTK
EHLGLALALNVPVFVVVTKIDMCPANILQETLKLLQRLLKSPGCRKIPVLVQSKDDVIVTASNFSSERMCPIFQISNVTGENLDLLKMFL
NLLSPRTSYREEEPAEFQIDDTYSVPGVGTVVSGTTLRGLIKLNDTLLLGPDPLGNFLSIAVKSIHRKRMPVKEVRGGQTASFALKKIKR
SSIRKGMVMVSPRLNPQASWEFEAEILVLHHPTTISPRYQAMVHCGSIRQTATILSMDKDCLRTGDKATVHFRFIKTPEYLHIDQRLVFR
EGRTKAVGTITKLLQTTNNSPMNSKPQQIKMQSTKKGPLTKRDEGGPSGGPAVGAPPPGDEASSVGAGQPAASSNLQPQPKPSSGGRRRG

--------------------------------------------------------------

>101404_101404_8_ZMYND8-GTPBP1_ZMYND8_chr20_45848908_ENST00000536340_GTPBP1_chr22_39111911_ENST00000216044_length(amino acids)=1753AA_BP=1185
MILQTGKGLAHLSFHQGMVFLEEFEARSCLAEEEIKTEQEVVEGMDISTRSKDPGSAERTAQKRKFPSPPHSSNGHSPQDTSTSPIKKKK
KPGLLNSNNKEQSELRHGPFYYMKQPLTTDPVDVVPQDGRNDFYCWVCHREGQVLCCELCPRVYHAKCLRLTSEPEGDWFCPECEKITVA
ECIETQSKAMTMLTIEQLSYLLKFAIQKMKQPGTDAFQKPVPLEQHPDYAEYIFHPMDLCTLEKNAKKKMYGCTEAFLADAKWILHNCII
YNGGNHKLTQIAKVVIKICEHEMNEIEVCPECYLAACQKRDNWFCEPCSNPHPLVWAKLKGFPFWPAKALRDKDGQVDARFFGQHDRAWV
PINNCYLMSKEIPFSVKKTKSIFNSAMQEMEVYVENIRRKFGVFNYSPFRTPYTPNSQYQMLLDPTNPSAGTAKIDKQEKVKLNFDMTAS
PKILMSKPVLSGGTGRRISLSDMPRSPMSTNSSVHTGSDVEQDAEKKATSSHFSASEESMDFLDKSTASPASTKTGQAGSLSGSPKPFSP
QLSAPITTKTDKTSTTGSILNLNLDRSKAEMDLKELSESVQQQSTPVPLISPKRQIRSRFQLNLDKTIESCKAQLGINEISEDVYTAVEH
SDSEDSEKSDSSDSEYISDDEQKSKNEPEDTEDKEGCQMDKEPSAVKKKPKPTNPVEIKEELKSTSPASEKADPGAVKDKASPEPEKDFS
EKAKPSPHPIKDKLKGKDETDSPTVHLGLDSDSESELVIDLGEDHSGREGRKNKKEPKEPSPKQDVVGKTPPSTTVGSHSPPETPVLTRS
SAQTSAAGATATTSTSSTVTVTAPAPAATGSPVKKQRPLLPKETAPAVQRVVWNSSSKFQTSSQKWHMQKMQRQQQQQQQQNQQQQPQSS
QGTRYQTRQAVKAVQQKEITQSPSTSTITLVTSTQSSPLVTSSGSMSTLVSSVNADLPIATASADVAADIAKYTSKMMDAIKGTMTEIYN
DLSKNTTGSTIAEIRRLRIEIEKLQWLHQQELSEMKHNLELTMAEMRQSLEQERDRLIAEVKKQLELEKQQAVDETKKKQWCANCKKEAI
FYCCWNTSYCDYPCQQAHWPEHMKSCTQSATAPQQEADAEVNTETLNKSSQGSSSSTQSAPSETASASKEKETSAEKSKESGSTLDLSGS
RETPSSILLGSNQGSDGTEYGLSEADMEASYATVKSMAEQIEADVILLRERQEAGGRVRDYLVRKRVGDNDFLEVRVAVVGNVDAGKSTL
LGVLTHGELDNGRGFARQKLFRHKHEIESGRTSSVGNDILGFDSEGNVVNKPDSHGGSLEWTKICEKSTKVITFIDLAGHEKYLKTTVFG
MTGHLPDFCMLMVGSNAGIVGMTKEHLGLALALNVPVFVVVTKIDMCPANILQETLKLLQRLLKSPGCRKIPVLVQSKDDVIVTASNFSS
ERMCPIFQISNVTGENLDLLKMFLNLLSPRTSYREEEPAEFQIDDTYSVPGVGTVVSGTTLRGLIKLNDTLLLGPDPLGNFLSIAVKSIH
RKRMPVKEVRGGQTASFALKKIKRSSIRKGMVMVSPRLNPQASWEFEAEILVLHHPTTISPRYQAMVHCGSIRQTATILSMDKDCLRTGD
KATVHFRFIKTPEYLHIDQRLVFREGRTKAVGTITKLLQTTNNSPMNSKPQQIKMQSTKKGPLTKRDEGGPSGGPAVGAPPPGDEASSVG

--------------------------------------------------------------

>101404_101404_9_ZMYND8-GTPBP1_ZMYND8_chr20_45848908_ENST00000540497_GTPBP1_chr22_39111911_ENST00000216044_length(amino acids)=1657AA_BP=1089
MHPQSLAEEEIKTEQEVVEGMDISTRSKDPGSAERTAQKRKFPSPPHSSNGHSPQDTSTSPIKKKKKPGLLNSNNKEQDGRNDFYCWVCH
REGQVLCCELCPRVYHAKCLRLTSEPEGDWFCPECEKITVAECIETQSKAMTMLTIEQLSYLLKFAIQKMKQPGTDAFQKPVPLEQHPDY
AEYIFHPMDLCTLEKNAKKKMYGCTEAFLADAKWILHNCIIYNGGNHKLTQIAKVVIKICEHEMNEIEVCPECYLAACQKRDNWFCEPCS
NPHPLVWAKLKGFPFWPAKALRDKDGQVDARFFGQHDRAWVPINNCYLMSKEIPFSVKKTKSIFNSAMQEMEVYVENIRRKFGVFNYSPF
RTPYTPNSQYQMLLDPTNPSAGTAKIDKQEKVKLNFDMTASPKILMSKPVLSGGTGRRISLSDMPRSPMSTNSSVHTGSDVEQDAEKKAT
SSHFSASEESMDFLDKSTDRSKAEMDLKELSESVQQQSTPVPLISPKRQIRSRFQLNLDKTIESCKAQLGINEISEDVYTAVEHSDSEDS
EKSDSSDSEYISDDEQKSKNEPEDTEDKEGCQMDKEPSAVKKKPKPTNPVEIKEELKSTSPASEKADPGAVKDKASPEPEKDFSEKAKPS
PHPIKDKLKGKDETDSPTVHLGLDSDSESELVIDLGEDHSGREGRKNKKEPKEPSPKQDVVGKTPPSTTVGSHSPPETPVLTRSSAQTSA
AGATATTSTSSTVTVTAPAPAATGSPVKKQRPLLPKETAPAVQRVVWNSSSKFQTSSQKWHMQKMQRQQQQQQQQNQQQQPQSSQGTRYQ
TRQAVKAVQQKEITQSPSTSTITLVTSTQSSPLVTSSGSMSTLVSSVNADLPIATASADVAADIAKYTSKMMDAIKGTMTEIYNDLSKNT
TGSTIAEIRRLRIEIEKLQWLHQQELSEMKHNLELTMAEMRQSLEQERDRLIAEVKKQLELEKQQAVDETKKKQWCANCKKEAIFYCCWN
TSYCDYPCQQAHWPEHMKSCTQSATAPQQEADAEVNTETLNKSSQGSSSSTQSAPSETASASKEKETSAEKSKESGSTLDLSGSRETPSS
ILLGSNQGSDGTEYGLSEADMEASYATVKSMAEQIEADVILLRERQEAGGRVRDYLVRKRVGDNDFLEVRVAVVGNVDAGKSTLLGVLTH
GELDNGRGFARQKLFRHKHEIESGRTSSVGNDILGFDSEGNVVNKPDSHGGSLEWTKICEKSTKVITFIDLAGHEKYLKTTVFGMTGHLP
DFCMLMVGSNAGIVGMTKEHLGLALALNVPVFVVVTKIDMCPANILQETLKLLQRLLKSPGCRKIPVLVQSKDDVIVTASNFSSERMCPI
FQISNVTGENLDLLKMFLNLLSPRTSYREEEPAEFQIDDTYSVPGVGTVVSGTTLRGLIKLNDTLLLGPDPLGNFLSIAVKSIHRKRMPV
KEVRGGQTASFALKKIKRSSIRKGMVMVSPRLNPQASWEFEAEILVLHHPTTISPRYQAMVHCGSIRQTATILSMDKDCLRTGDKATVHF
RFIKTPEYLHIDQRLVFREGRTKAVGTITKLLQTTNNSPMNSKPQQIKMQSTKKGPLTKRDEGGPSGGPAVGAPPPGDEASSVGAGQPAA

--------------------------------------------------------------

>101404_101404_10_ZMYND8-GTPBP1_ZMYND8_chr20_45848909_ENST00000352431_GTPBP1_chr22_39111912_ENST00000216044_length(amino acids)=1683AA_BP=1115
MHPQSLAEEEIKTEQEVVEGMDISTRSKDPGSAERTAQKRKFPSPPHSSNGHSPQDTSTSPIKKKKKPGLLNSNNKEQSELRHGPFYYMK
QPLTTDPVDVVPQDGRNDFYCWVCHREGQVLCCELCPRVYHAKCLRLTSEPEGDWFCPECEKITVAECIETQSKAMTMLTIEQLSYLLKF
AIQKMKQPGTDAFQKPVPLEQHPDYAEYIFHPMDLCTLEKNAKKKMYGCTEAFLADAKWILHNCIIYNGGNHKLTQIAKVVIKICEHEMN
EIEVCPECYLAACQKRDNWFCEPCSNPHPLVWAKLKGFPFWPAKALRDKDGQVDARFFGQHDRAWVPINNCYLMSKEIPFSVKKTKSIFN
SAMQEMEVYVENIRRKFGVFNYSPFRTPYTPNSQYQMLLDPTNPSAGTAKIDKQEKVKLNFDMTASPKILMSKPVLSGGTGRRISLSDMP
RSPMSTNSSVHTGSDVEQDAEKKATSSHFSASEESMDFLDKSTASPASTKTGQAGSLSGSPKPFSPQLSAPITTKTDKTSTTGSILNLNL
DRSKAEMDLKELSESVQQQSTPVPLISPKRQIRSRFQLNLDKTIESCKAQLGINEISEDVYTAVEHSDSEDSEKSDSSDSEYISDDEQKS
KNEPEDTEDKEGCQMDKEPSAVKKKPKPTNPVEIKEELKSTSPASEKADPGAVKDKASPEPEKDFSEKAKPSPHPIKDKLKGKDETDSPT
VHLGLDSDSESELVIDLGEDHSGREGRKNKKEPKEPSPKQDVVGKTPPSTTVGSHSPPETPVLTRSSAQTSAAGATATTSTSSTVTVTAP
APAATGSPVKKQRPLLPKETAPAVQRVVWNSSTVQQKEITQSPSTSTITLVTSTQSSPLVTSSGSMSTLVSSVNADLPIATASADVAADI
AKYTSKMMDAIKGTMTEIYNDLSKNTTGSTIAEIRRLRIEIEKLQWLHQQELSEMKHNLELTMAEMRQSLEQERDRLIAEVKKQLELEKQ
QAVDETKKKQWCANCKKEAIFYCCWNTSYCDYPCQQAHWPEHMKSCTQSATAPQQEADAEVNTETLNKSSQGSSSSTQSAPSETASASKE
KETSAEKSKESGSTLDLSGSRETPSSILLGSNQGSDGTEYGLSEADMEASYATVKSMAEQIEADVILLRERQEAGGRVRDYLVRKRVGDN
DFLEVRVAVVGNVDAGKSTLLGVLTHGELDNGRGFARQKLFRHKHEIESGRTSSVGNDILGFDSEGNVVNKPDSHGGSLEWTKICEKSTK
VITFIDLAGHEKYLKTTVFGMTGHLPDFCMLMVGSNAGIVGMTKEHLGLALALNVPVFVVVTKIDMCPANILQETLKLLQRLLKSPGCRK
IPVLVQSKDDVIVTASNFSSERMCPIFQISNVTGENLDLLKMFLNLLSPRTSYREEEPAEFQIDDTYSVPGVGTVVSGTTLRGLIKLNDT
LLLGPDPLGNFLSIAVKSIHRKRMPVKEVRGGQTASFALKKIKRSSIRKGMVMVSPRLNPQASWEFEAEILVLHHPTTISPRYQAMVHCG
SIRQTATILSMDKDCLRTGDKATVHFRFIKTPEYLHIDQRLVFREGRTKAVGTITKLLQTTNNSPMNSKPQQIKMQSTKKGPLTKRDEGG

--------------------------------------------------------------

>101404_101404_11_ZMYND8-GTPBP1_ZMYND8_chr20_45848909_ENST00000360911_GTPBP1_chr22_39111912_ENST00000216044_length(amino acids)=1658AA_BP=1090
MHPQSLAEEEIKTEQEVVEGMDISTRSKDPGSAERTAQKRKFPSPPHSSNGHSPQDTSTSPIKKKKKPGLLNSNNKEQDGRNDFYCWVCH
REGQVLCCELCPRVYHAKCLRLTSEPEGDWFCPECEKITVAECIETQSKAMTMLTIEQLSYLLKFAIQKMKQPGTDAFQKPVPLEQHPDY
AEYIFHPMDLCTLEKNAKKKMYGCTEAFLADAKWILHNCIIYNGGNHKLTQIAKVVIKICEHEMNEIEVCPECYLAACQKRDNWFCEPCS
NPHPLVWAKLKGFPFWPAKALRDKDGQVDARFFGQHDRAWVPINNCYLMSKEIPFSVKKTKSIFNSAMQEMEVYVENIRRKFGVFNYSPF
RTPYTPNSQYQMLLDPTNPSAGTAKIDKQEKVKLNFDMTASPKILMSKPVLSGGTGRRISLSDMPRSPMSTNSSVHTGSDVEQDAEKKAT
SSHFSASEESMDFLDKSTASPASTKTGQAGSLSGSPKPFSPQLSAPITTKTDKTSTTGSILNLNLDRSKAEMDLKELSESVQQQSTPVPL
ISPKRQIRSRFQLNLDKTIESCKAQLGINEISEDVYTAVEHSDSEDSEKSDSSDSEYISDDEQKSKNEPEDTEDKEGCQMDKEPSAVKKK
PKPTNPVEIKEELKSTSPASEKADPGAVKDKASPEPEKDFSEKAKPSPHPIKDKLKGKDETDSPTVHLGLDSDSESELVIDLGEDHSGRE
GRKNKKEPKEPSPKQDVVGKTPPSTTVGSHSPPETPVLTRSSAQTSAAGATATTSTSSTVTVTAPAPAATGSPVKKQRPLLPKETAPAVQ
RVVWNSSTVQQKEITQSPSTSTITLVTSTQSSPLVTSSGSMSTLVSSVNADLPIATASADVAADIAKYTSKMMDAIKGTMTEIYNDLSKN
TTGSTIAEIRRLRIEIEKLQWLHQQELSEMKHNLELTMAEMRQSLEQERDRLIAEVKKQLELEKQQAVDETKKKQWCANCKKEAIFYCCW
NTSYCDYPCQQAHWPEHMKSCTQSATAPQQEADAEVNTETLNKSSQGSSSSTQSAPSETASASKEKETSAEKSKESGSTLDLSGSRETPS
SILLGSNQGSDGTEYGLSEADMEASYATVKSMAEQIEADVILLRERQEAGGRVRDYLVRKRVGDNDFLEVRVAVVGNVDAGKSTLLGVLT
HGELDNGRGFARQKLFRHKHEIESGRTSSVGNDILGFDSEGNVVNKPDSHGGSLEWTKICEKSTKVITFIDLAGHEKYLKTTVFGMTGHL
PDFCMLMVGSNAGIVGMTKEHLGLALALNVPVFVVVTKIDMCPANILQETLKLLQRLLKSPGCRKIPVLVQSKDDVIVTASNFSSERMCP
IFQISNVTGENLDLLKMFLNLLSPRTSYREEEPAEFQIDDTYSVPGVGTVVSGTTLRGLIKLNDTLLLGPDPLGNFLSIAVKSIHRKRMP
VKEVRGGQTASFALKKIKRSSIRKGMVMVSPRLNPQASWEFEAEILVLHHPTTISPRYQAMVHCGSIRQTATILSMDKDCLRTGDKATVH
FRFIKTPEYLHIDQRLVFREGRTKAVGTITKLLQTTNNSPMNSKPQQIKMQSTKKGPLTKRDEGGPSGGPAVGAPPPGDEASSVGAGQPA

--------------------------------------------------------------

>101404_101404_12_ZMYND8-GTPBP1_ZMYND8_chr20_45848909_ENST00000372023_GTPBP1_chr22_39111912_ENST00000216044_length(amino acids)=1631AA_BP=1063
MHPQSLAEEEIKTEQEVVEGMDISTRSKDPGSAERTAQKRKFPSPPHSSNGHSPQDTSTSPIKKKKKPGLLNSNNKEQDGRNDFYCWVCH
REGQVLCCELCPRVYHAKCLRLTSEPEGDWFCPECEKITVAECIETQSKAMTMLTIEQLSYLLKFAIQKMKQPGTDAFQKPVPLEQHPDY
AEYIFHPMDLCTLEKNAKKKMYGCTEAFLADAKWILHNCIIYNGGNHKLTQIAKVVIKICEHEMNEIEVCPECYLAACQKRDNWFCEPCS
NPHPLVWAKLKGFPFWPAKALRDKDGQVDARFFGQHDRAWVPINNCYLMSKEIPFSVKKTKSIFNSAMQEMEVYVENIRRKFGVFNYSPF
RTPYTPNSQYQMLLDPTNPSAGTAKIDKQEKVKLNFDMTASPKILMSKPVLSGGTGRRISLSDMPRSPMSTNSSVHTGSDVEQDAEKKAT
SSHFSASEESMDFLDKSTASPASTKTGQAGSLSGSPKPFSPQLSAPITTKTDKTSTTGSILNLNLDRSKAEMDLKELSESVQQQSTPVPL
ISPKRQIRSRFQLNLDKTIESCKAQLGINEISEDVYTAVEHSDSEDSEKSDSSDSEYISDDEQKSKNEPEDTEDKEGCQMDKEPSAVKKK
PKPTNPVEIKEELKSTSPASEKADPGAVKDKASPEPEKDFSEKAKPSPHPIKDKLKGKDETDSPTVHLGLDSDSESELVIDLGEDHSGRE
GRKNKKEPKEPSPKQDVVGKTPPSTTVGSHSPPETPVLTRSSAQTSAAGATATTSTSSTVTVTAPAPAATGSPVKKQRPLLPKETAPAVQ
RVVWNSSTVQQKEITQSPSTSTITLVTSTQSSPLVTSSGSMSTLVSSVNADLPIATASADVAADIAKYTSKIRRLRIEIEKLQWLHQQEL
SEMKHNLELTMAEMRQSLEQERDRLIAEVKKQLELEKQQAVDETKKKQWCANCKKEAIFYCCWNTSYCDYPCQQAHWPEHMKSCTQSATA
PQQEADAEVNTETLNKSSQGSSSSTQSAPSETASASKEKETSAEKSKESGSTLDLSGSRETPSSILLGSNQGSDGTEYGLSEADMEASYA
TVKSMAEQIEADVILLRERQEAGGRVRDYLVRKRVGDNDFLEVRVAVVGNVDAGKSTLLGVLTHGELDNGRGFARQKLFRHKHEIESGRT
SSVGNDILGFDSEGNVVNKPDSHGGSLEWTKICEKSTKVITFIDLAGHEKYLKTTVFGMTGHLPDFCMLMVGSNAGIVGMTKEHLGLALA
LNVPVFVVVTKIDMCPANILQETLKLLQRLLKSPGCRKIPVLVQSKDDVIVTASNFSSERMCPIFQISNVTGENLDLLKMFLNLLSPRTS
YREEEPAEFQIDDTYSVPGVGTVVSGTTLRGLIKLNDTLLLGPDPLGNFLSIAVKSIHRKRMPVKEVRGGQTASFALKKIKRSSIRKGMV
MVSPRLNPQASWEFEAEILVLHHPTTISPRYQAMVHCGSIRQTATILSMDKDCLRTGDKATVHFRFIKTPEYLHIDQRLVFREGRTKAVG
TITKLLQTTNNSPMNSKPQQIKMQSTKKGPLTKRDEGGPSGGPAVGAPPPGDEASSVGAGQPAASSNLQPQPKPSSGGRRRGGQRHKVKS

--------------------------------------------------------------

>101404_101404_13_ZMYND8-GTPBP1_ZMYND8_chr20_45848909_ENST00000396281_GTPBP1_chr22_39111912_ENST00000216044_length(amino acids)=1709AA_BP=1141
MFSSLQKSFNLAEEEIKTEQEVVEGMDISTRSKDPGSAERTAQKRKFPSPPHSSNGHSPQDTSTSPIKKKKKPGLLNSNNKEQDGRNDFY
CWVCHREGQVLCCELCPRVYHAKCLRLTSEPEGDWFCPECEKITVAECIETQSKAMTMLTIEQLSYLLKFAIQKMKQPGTDAFQKPVPLE
QHPDYAEYIFHPMDLCTLEKNAKKKMYGCTEAFLADAKWILHNCIIYNGGNHKLTQIAKVVIKICEHEMNEIEVCPECYLAACQKRDNWF
CEPCSNPHPLVWAKLKGFPFWPAKALRDKDGQVDARFFGQHDRAWVPINNCYLMSKEIPFSVKKTKSIFNSAMQEMEVYVENIRRKFGVF
NYSPFRTPYTPNSQYQMLLDPTNPSAGTAKIDKQEKVKLNFDMTASPKILMSKPVLSGGTGRRISLSDMPRSPMSTNSSVHTGSDVEQDA
EKKATSSHFSASEESMDFLDKSTASPASTKTGQAGSLSGSPKPFSPQLSAPITTKTDKTSTTGSILNLNLDRSKAEMDLKELSESVQQQS
TPVPLISPKRQIRSRFQLNLDKTIESCKAQLGINEISEDVYTAVEHSDSEDSEKSDSSDSEYISDDEQKSKNEPEDTEDKEGCQMDKEPS
AVKKKPKPTNPVEIKEELKSTSPASEKADPGAVKDKASPEPEKDFSEKAKPSPHPIKDKLKGKDETDSPTVHLGLDSDSESELVIDLGED
HSGREGRKNKKEPKEPSPKQDVVGKTPPSTTVGSHSPPETPVLTRSSAQTSAAGATATTSTSSTVTVTAPAPAATGSPVKKQRPLLPKET
APAVQRVVWNSSSKFQTSSQKWHMQKMQRQQQQQQQQNQQQQPQSSQGTRYQTRQAVKAVQQKEITQSPSTSTITLVTSTQSSPLVTSSG
SMSTLVSSVNADLPIATASADVAADIAKYTSKMMDAIKGTMTEIYNDLSKNTTGSTIAEIRRLRIEIEKLQWLHQQELSEMKHNLELTMA
EMRQSLEQERDRLIAEVKKQLELEKQQAVDETKKKQWCANCKKEAIFYCCWNTSYCDYPCQQAHWPEHMKSCTQSATAPQQEADAEVNTE
TLNKSSQGSSSSTQSAPSETASASKEKETSAEKSKESGSTLDLSGSRETPSSILLGSNQGSDGTEYGLSEADMEASYATVKSMAEQIEAD
VILLRERQEAGGRVRDYLVRKRVGDNDFLEVRVAVVGNVDAGKSTLLGVLTHGELDNGRGFARQKLFRHKHEIESGRTSSVGNDILGFDS
EGNVVNKPDSHGGSLEWTKICEKSTKVITFIDLAGHEKYLKTTVFGMTGHLPDFCMLMVGSNAGIVGMTKEHLGLALALNVPVFVVVTKI
DMCPANILQETLKLLQRLLKSPGCRKIPVLVQSKDDVIVTASNFSSERMCPIFQISNVTGENLDLLKMFLNLLSPRTSYREEEPAEFQID
DTYSVPGVGTVVSGTTLRGLIKLNDTLLLGPDPLGNFLSIAVKSIHRKRMPVKEVRGGQTASFALKKIKRSSIRKGMVMVSPRLNPQASW
EFEAEILVLHHPTTISPRYQAMVHCGSIRQTATILSMDKDCLRTGDKATVHFRFIKTPEYLHIDQRLVFREGRTKAVGTITKLLQTTNNS

--------------------------------------------------------------

>101404_101404_14_ZMYND8-GTPBP1_ZMYND8_chr20_45848909_ENST00000458360_GTPBP1_chr22_39111912_ENST00000216044_length(amino acids)=1577AA_BP=1009
MHPQSLAEEEIKTEQEVVEGMDISTRSKDPGSAERTAQKRKFPSPPHSSNGHSPQDTSTSPIKKKKKPGLLNSNNKEQDGRNDFYCWVCH
REGQVLCCELCPRVYHAKCLRLTSEPEGDWFCPECEKITVAECIETQSKAMTMLTIEQLSYLLKFAIQKMKQPGTDAFQKPVPLEQHPDY
AEYIFHPMDLCTLEKNAKKKMYGCTEAFLADAKWILHNCIIYNGGNHKLTQIAKVVIKICEHEMNEIEVCPECYLAACQKRDNWFCEPCS
NPHPLVWAKLKGFPFWPAKALRDKDGQVDARFFGQHDRAWVPINNCYLMSKEIPFSVKKTKSIFNSAMQEMEVYVENIRRKFGVFNYSPF
RTPYTPNSQYQMLLDPTNPSAGTAKIDKQEKVKLNFDMTASPKILMSKPVLSGGTGRRISLSDMPRSPMSTNSSVHTGSDVEQDAEKKAT
SSHFSASEESMDFLDKSTASPASTKTGQAGSLSGSPKPFSPQLSAPITTKTDKTSTTGSILNLNLDRSKAEMDLKELSESVQQQSTPVPL
ISPKRQIRSRFQLNLDKTIESCKAQLGINEISEDVYTAVEHSDSEDSEKSDSSDSEYISDDEQKSKNEPEDTEDKEGCQMDKEPSAVKKK
PKPTNPVEIKEELKSTSPASEKADPGAVKDKASPEPEKDFSEKAKPSPHPIKDKLKGKDETDSPTVHLGLDSDSESELVIDLGEDHSGRE
GRKNKKEPKEPSPKQDAVQQKEITQSPSTSTITLVTSTQSSPLVTSSGSMSTLVSSVNADLPIATASADVAADIAKYTSKMMDAIKGTMT
EIYNDLSKNTTGSTIAEIRRLRIEIEKLQWLHQQELSEMKHNLELTMAEMRQSLEQERDRLIAEVKKQLELEKQQAVDETKKKQWCANCK
KEAIFYCCWNTSYCDYPCQQAHWPEHMKSCTQSATAPQQEADAEVNTETLNKSSQGSSSSTQSAPSETASASKEKETSAEKSKESGSTLD
LSGSRETPSSILLGSNQGSDGTEYGLSEADMEASYATVKSMAEQIEADVILLRERQEAGGRVRDYLVRKRVGDNDFLEVRVAVVGNVDAG
KSTLLGVLTHGELDNGRGFARQKLFRHKHEIESGRTSSVGNDILGFDSEGNVVNKPDSHGGSLEWTKICEKSTKVITFIDLAGHEKYLKT
TVFGMTGHLPDFCMLMVGSNAGIVGMTKEHLGLALALNVPVFVVVTKIDMCPANILQETLKLLQRLLKSPGCRKIPVLVQSKDDVIVTAS
NFSSERMCPIFQISNVTGENLDLLKMFLNLLSPRTSYREEEPAEFQIDDTYSVPGVGTVVSGTTLRGLIKLNDTLLLGPDPLGNFLSIAV
KSIHRKRMPVKEVRGGQTASFALKKIKRSSIRKGMVMVSPRLNPQASWEFEAEILVLHHPTTISPRYQAMVHCGSIRQTATILSMDKDCL
RTGDKATVHFRFIKTPEYLHIDQRLVFREGRTKAVGTITKLLQTTNNSPMNSKPQQIKMQSTKKGPLTKRDEGGPSGGPAVGAPPPGDEA

--------------------------------------------------------------

>101404_101404_15_ZMYND8-GTPBP1_ZMYND8_chr20_45848909_ENST00000461685_GTPBP1_chr22_39111912_ENST00000216044_length(amino acids)=1683AA_BP=1115
MHPQSLAEEEIKTEQEVVEGMDISTRSKDPGSAERTAQKRKFPSPPHSSNGHSPQDTSTSPIKKKKKPGLLNSNNKEQSELRHGPFYYMK
QPLTTDPVDVVPQDGRNDFYCWVCHREGQVLCCELCPRVYHAKCLRLTSEPEGDWFCPECEKITVAECIETQSKAMTMLTIEQLSYLLKF
AIQKMKQPGTDAFQKPVPLEQHPDYAEYIFHPMDLCTLEKNAKKKMYGCTEAFLADAKWILHNCIIYNGGNHKLTQIAKVVIKICEHEMN
EIEVCPECYLAACQKRDNWFCEPCSNPHPLVWAKLKGFPFWPAKALRDKDGQVDARFFGQHDRAWVPINNCYLMSKEIPFSVKKTKSIFN
SAMQEMEVYVENIRRKFGVFNYSPFRTPYTPNSQYQMLLDPTNPSAGTAKIDKQEKVKLNFDMTASPKILMSKPVLSGGTGRRISLSDMP
RSPMSTNSSVHTGSDVEQDAEKKATSSHFSASEESMDFLDKSTASPASTKTGQAGSLSGSPKPFSPQLSAPITTKTDKTSTTGSILNLNL
DRSKAEMDLKELSESVQQQSTPVPLISPKRQIRSRFQLNLDKTIESCKAQLGINEISEDVYTAVEHSDSEDSEKSDSSDSEYISDDEQKS
KNEPEDTEDKEGCQMDKEPSAVKKKPKPTNPVEIKEELKSTSPASEKADPGAVKDKASPEPEKDFSEKAKPSPHPIKDKLKGKDETDSPT
VHLGLDSDSESELVIDLGEDHSGREGRKNKKEPKEPSPKQDVVGKTPPSTTVGSHSPPETPVLTRSSAQTSAAGATATTSTSSTVTVTAP
APAATGSPVKKQRPLLPKETAPAVQRVVWNSSTVQQKEITQSPSTSTITLVTSTQSSPLVTSSGSMSTLVSSVNADLPIATASADVAADI
AKYTSKMMDAIKGTMTEIYNDLSKNTTGSTIAEIRRLRIEIEKLQWLHQQELSEMKHNLELTMAEMRQSLEQERDRLIAEVKKQLELEKQ
QAVDETKKKQWCANCKKEAIFYCCWNTSYCDYPCQQAHWPEHMKSCTQSATAPQQEADAEVNTETLNKSSQGSSSSTQSAPSETASASKE
KETSAEKSKESGSTLDLSGSRETPSSILLGSNQGSDGTEYGLSEADMEASYATVKSMAEQIEADVILLRERQEAGGRVRDYLVRKRVGDN
DFLEVRVAVVGNVDAGKSTLLGVLTHGELDNGRGFARQKLFRHKHEIESGRTSSVGNDILGFDSEGNVVNKPDSHGGSLEWTKICEKSTK
VITFIDLAGHEKYLKTTVFGMTGHLPDFCMLMVGSNAGIVGMTKEHLGLALALNVPVFVVVTKIDMCPANILQETLKLLQRLLKSPGCRK
IPVLVQSKDDVIVTASNFSSERMCPIFQISNVTGENLDLLKMFLNLLSPRTSYREEEPAEFQIDDTYSVPGVGTVVSGTTLRGLIKLNDT
LLLGPDPLGNFLSIAVKSIHRKRMPVKEVRGGQTASFALKKIKRSSIRKGMVMVSPRLNPQASWEFEAEILVLHHPTTISPRYQAMVHCG
SIRQTATILSMDKDCLRTGDKATVHFRFIKTPEYLHIDQRLVFREGRTKAVGTITKLLQTTNNSPMNSKPQQIKMQSTKKGPLTKRDEGG

--------------------------------------------------------------

>101404_101404_16_ZMYND8-GTPBP1_ZMYND8_chr20_45848909_ENST00000471951_GTPBP1_chr22_39111912_ENST00000216044_length(amino acids)=1729AA_BP=1161
MHPQSLAEEEIKTEQEVVEGMDISTRSKDPGSAERTAQKRKFPSPPHSSNGHSPQDTSTSPIKKKKKPGLLNSNNKEQSELRHGPFYYMK
QPLTTDPVDVVPQDGRNDFYCWVCHREGQVLCCELCPRVYHAKCLRLTSEPEGDWFCPECEKITVAECIETQSKAMTMLTIEQLSYLLKF
AIQKMKQPGTDAFQKPVPLEQHPDYAEYIFHPMDLCTLEKNAKKKMYGCTEAFLADAKWILHNCIIYNGGNHKLTQIAKVVIKICEHEMN
EIEVCPECYLAACQKRDNWFCEPCSNPHPLVWAKLKGFPFWPAKALRDKDGQVDARFFGQHDRAWVPINNCYLMSKEIPFSVKKTKSIFN
SAMQEMEVYVENIRRKFGVFNYSPFRTPYTPNSQYQMLLDPTNPSAGTAKIDKQEKVKLNFDMTASPKILMSKPVLSGGTGRRISLSDMP
RSPMSTNSSVHTGSDVEQDAEKKATSSHFSASEESMDFLDKSTASPASTKTGQAGSLSGSPKPFSPQLSAPITTKTDKTSTTGSILNLNL
DRSKAEMDLKELSESVQQQSTPVPLISPKRQIRSRFQLNLDKTIESCKAQLGINEISEDVYTAVEHSDSEDSEKSDSSDSEYISDDEQKS
KNEPEDTEDKEGCQMDKEPSAVKKKPKPTNPVEIKEELKSTSPASEKADPGAVKDKASPEPEKDFSEKAKPSPHPIKDKLKGKDETDSPT
VHLGLDSDSESELVIDLGEDHSGREGRKNKKEPKEPSPKQDVVGKTPPSTTVGSHSPPETPVLTRSSAQTSAAGATATTSTSSTVTVTAP
APAATGSPVKKQRPLLPKETAPAVQRVVWNSSSKFQTSSQKWHMQKMQRQQQQQQQQNQQQQPQSSQGTRYQTRQAVKAVQQKEITQSPS
TSTITLVTSTQSSPLVTSSGSMSTLVSSVNADLPIATASADVAADIAKYTSKMMDAIKGTMTEIYNDLSKNTTGSTIAEIRRLRIEIEKL
QWLHQQELSEMKHNLELTMAEMRQSLEQERDRLIAEVKKQLELEKQQAVDETKKKQWCANCKKEAIFYCCWNTSYCDYPCQQAHWPEHMK
SCTQSATAPQQEADAEVNTETLNKSSQGSSSSTQSAPSETASASKEKETSAEKSKESGSTLDLSGSRETPSSILLGSNQGSDGTEYGLSE
ADMEASYATVKSMAEQIEADVILLRERQEAGGRVRDYLVRKRVGDNDFLEVRVAVVGNVDAGKSTLLGVLTHGELDNGRGFARQKLFRHK
HEIESGRTSSVGNDILGFDSEGNVVNKPDSHGGSLEWTKICEKSTKVITFIDLAGHEKYLKTTVFGMTGHLPDFCMLMVGSNAGIVGMTK
EHLGLALALNVPVFVVVTKIDMCPANILQETLKLLQRLLKSPGCRKIPVLVQSKDDVIVTASNFSSERMCPIFQISNVTGENLDLLKMFL
NLLSPRTSYREEEPAEFQIDDTYSVPGVGTVVSGTTLRGLIKLNDTLLLGPDPLGNFLSIAVKSIHRKRMPVKEVRGGQTASFALKKIKR
SSIRKGMVMVSPRLNPQASWEFEAEILVLHHPTTISPRYQAMVHCGSIRQTATILSMDKDCLRTGDKATVHFRFIKTPEYLHIDQRLVFR
EGRTKAVGTITKLLQTTNNSPMNSKPQQIKMQSTKKGPLTKRDEGGPSGGPAVGAPPPGDEASSVGAGQPAASSNLQPQPKPSSGGRRRG

--------------------------------------------------------------

>101404_101404_17_ZMYND8-GTPBP1_ZMYND8_chr20_45848909_ENST00000536340_GTPBP1_chr22_39111912_ENST00000216044_length(amino acids)=1753AA_BP=1185
MILQTGKGLAHLSFHQGMVFLEEFEARSCLAEEEIKTEQEVVEGMDISTRSKDPGSAERTAQKRKFPSPPHSSNGHSPQDTSTSPIKKKK
KPGLLNSNNKEQSELRHGPFYYMKQPLTTDPVDVVPQDGRNDFYCWVCHREGQVLCCELCPRVYHAKCLRLTSEPEGDWFCPECEKITVA
ECIETQSKAMTMLTIEQLSYLLKFAIQKMKQPGTDAFQKPVPLEQHPDYAEYIFHPMDLCTLEKNAKKKMYGCTEAFLADAKWILHNCII
YNGGNHKLTQIAKVVIKICEHEMNEIEVCPECYLAACQKRDNWFCEPCSNPHPLVWAKLKGFPFWPAKALRDKDGQVDARFFGQHDRAWV
PINNCYLMSKEIPFSVKKTKSIFNSAMQEMEVYVENIRRKFGVFNYSPFRTPYTPNSQYQMLLDPTNPSAGTAKIDKQEKVKLNFDMTAS
PKILMSKPVLSGGTGRRISLSDMPRSPMSTNSSVHTGSDVEQDAEKKATSSHFSASEESMDFLDKSTASPASTKTGQAGSLSGSPKPFSP
QLSAPITTKTDKTSTTGSILNLNLDRSKAEMDLKELSESVQQQSTPVPLISPKRQIRSRFQLNLDKTIESCKAQLGINEISEDVYTAVEH
SDSEDSEKSDSSDSEYISDDEQKSKNEPEDTEDKEGCQMDKEPSAVKKKPKPTNPVEIKEELKSTSPASEKADPGAVKDKASPEPEKDFS
EKAKPSPHPIKDKLKGKDETDSPTVHLGLDSDSESELVIDLGEDHSGREGRKNKKEPKEPSPKQDVVGKTPPSTTVGSHSPPETPVLTRS
SAQTSAAGATATTSTSSTVTVTAPAPAATGSPVKKQRPLLPKETAPAVQRVVWNSSSKFQTSSQKWHMQKMQRQQQQQQQQNQQQQPQSS
QGTRYQTRQAVKAVQQKEITQSPSTSTITLVTSTQSSPLVTSSGSMSTLVSSVNADLPIATASADVAADIAKYTSKMMDAIKGTMTEIYN
DLSKNTTGSTIAEIRRLRIEIEKLQWLHQQELSEMKHNLELTMAEMRQSLEQERDRLIAEVKKQLELEKQQAVDETKKKQWCANCKKEAI
FYCCWNTSYCDYPCQQAHWPEHMKSCTQSATAPQQEADAEVNTETLNKSSQGSSSSTQSAPSETASASKEKETSAEKSKESGSTLDLSGS
RETPSSILLGSNQGSDGTEYGLSEADMEASYATVKSMAEQIEADVILLRERQEAGGRVRDYLVRKRVGDNDFLEVRVAVVGNVDAGKSTL
LGVLTHGELDNGRGFARQKLFRHKHEIESGRTSSVGNDILGFDSEGNVVNKPDSHGGSLEWTKICEKSTKVITFIDLAGHEKYLKTTVFG
MTGHLPDFCMLMVGSNAGIVGMTKEHLGLALALNVPVFVVVTKIDMCPANILQETLKLLQRLLKSPGCRKIPVLVQSKDDVIVTASNFSS
ERMCPIFQISNVTGENLDLLKMFLNLLSPRTSYREEEPAEFQIDDTYSVPGVGTVVSGTTLRGLIKLNDTLLLGPDPLGNFLSIAVKSIH
RKRMPVKEVRGGQTASFALKKIKRSSIRKGMVMVSPRLNPQASWEFEAEILVLHHPTTISPRYQAMVHCGSIRQTATILSMDKDCLRTGD
KATVHFRFIKTPEYLHIDQRLVFREGRTKAVGTITKLLQTTNNSPMNSKPQQIKMQSTKKGPLTKRDEGGPSGGPAVGAPPPGDEASSVG

--------------------------------------------------------------

>101404_101404_18_ZMYND8-GTPBP1_ZMYND8_chr20_45848909_ENST00000540497_GTPBP1_chr22_39111912_ENST00000216044_length(amino acids)=1657AA_BP=1089
MHPQSLAEEEIKTEQEVVEGMDISTRSKDPGSAERTAQKRKFPSPPHSSNGHSPQDTSTSPIKKKKKPGLLNSNNKEQDGRNDFYCWVCH
REGQVLCCELCPRVYHAKCLRLTSEPEGDWFCPECEKITVAECIETQSKAMTMLTIEQLSYLLKFAIQKMKQPGTDAFQKPVPLEQHPDY
AEYIFHPMDLCTLEKNAKKKMYGCTEAFLADAKWILHNCIIYNGGNHKLTQIAKVVIKICEHEMNEIEVCPECYLAACQKRDNWFCEPCS
NPHPLVWAKLKGFPFWPAKALRDKDGQVDARFFGQHDRAWVPINNCYLMSKEIPFSVKKTKSIFNSAMQEMEVYVENIRRKFGVFNYSPF
RTPYTPNSQYQMLLDPTNPSAGTAKIDKQEKVKLNFDMTASPKILMSKPVLSGGTGRRISLSDMPRSPMSTNSSVHTGSDVEQDAEKKAT
SSHFSASEESMDFLDKSTDRSKAEMDLKELSESVQQQSTPVPLISPKRQIRSRFQLNLDKTIESCKAQLGINEISEDVYTAVEHSDSEDS
EKSDSSDSEYISDDEQKSKNEPEDTEDKEGCQMDKEPSAVKKKPKPTNPVEIKEELKSTSPASEKADPGAVKDKASPEPEKDFSEKAKPS
PHPIKDKLKGKDETDSPTVHLGLDSDSESELVIDLGEDHSGREGRKNKKEPKEPSPKQDVVGKTPPSTTVGSHSPPETPVLTRSSAQTSA
AGATATTSTSSTVTVTAPAPAATGSPVKKQRPLLPKETAPAVQRVVWNSSSKFQTSSQKWHMQKMQRQQQQQQQQNQQQQPQSSQGTRYQ
TRQAVKAVQQKEITQSPSTSTITLVTSTQSSPLVTSSGSMSTLVSSVNADLPIATASADVAADIAKYTSKMMDAIKGTMTEIYNDLSKNT
TGSTIAEIRRLRIEIEKLQWLHQQELSEMKHNLELTMAEMRQSLEQERDRLIAEVKKQLELEKQQAVDETKKKQWCANCKKEAIFYCCWN
TSYCDYPCQQAHWPEHMKSCTQSATAPQQEADAEVNTETLNKSSQGSSSSTQSAPSETASASKEKETSAEKSKESGSTLDLSGSRETPSS
ILLGSNQGSDGTEYGLSEADMEASYATVKSMAEQIEADVILLRERQEAGGRVRDYLVRKRVGDNDFLEVRVAVVGNVDAGKSTLLGVLTH
GELDNGRGFARQKLFRHKHEIESGRTSSVGNDILGFDSEGNVVNKPDSHGGSLEWTKICEKSTKVITFIDLAGHEKYLKTTVFGMTGHLP
DFCMLMVGSNAGIVGMTKEHLGLALALNVPVFVVVTKIDMCPANILQETLKLLQRLLKSPGCRKIPVLVQSKDDVIVTASNFSSERMCPI
FQISNVTGENLDLLKMFLNLLSPRTSYREEEPAEFQIDDTYSVPGVGTVVSGTTLRGLIKLNDTLLLGPDPLGNFLSIAVKSIHRKRMPV
KEVRGGQTASFALKKIKRSSIRKGMVMVSPRLNPQASWEFEAEILVLHHPTTISPRYQAMVHCGSIRQTATILSMDKDCLRTGDKATVHF
RFIKTPEYLHIDQRLVFREGRTKAVGTITKLLQTTNNSPMNSKPQQIKMQSTKKGPLTKRDEGGPSGGPAVGAPPPGDEASSVGAGQPAA

--------------------------------------------------------------

Top

Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr20:45848909/chr22:39111912)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.GTPBP1

A4D1E9

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: May be involved in the ribosome maturation process. Complements an ObgE(CgtA) function in E.coli ribosome maturation. Plays a role of GTPase in vitro. When missing, disorganization of the nucleolar architecture is observed. {ECO:0000269|PubMed:17054726}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneZMYND8chr20:45848908chr22:39111911ENST00000262975-22241089_10921095.33333333333331169.0Compositional biasNote=Poly-Ser
HgeneZMYND8chr20:45848908chr22:39111911ENST00000262975-222443_471095.33333333333331169.0Compositional biasNote=Poly-Lys
HgeneZMYND8chr20:45848908chr22:39111911ENST00000262975-2224838_8541095.33333333333331169.0Compositional biasNote=Poly-Gln
HgeneZMYND8chr20:45848908chr22:39111911ENST00000311275-21221089_10921141.33333333333331187.0Compositional biasNote=Poly-Ser
HgeneZMYND8chr20:45848908chr22:39111911ENST00000311275-212243_471141.33333333333331187.0Compositional biasNote=Poly-Lys
HgeneZMYND8chr20:45848908chr22:39111911ENST00000311275-2122838_8541141.33333333333331187.0Compositional biasNote=Poly-Gln
HgeneZMYND8chr20:45848908chr22:39111911ENST00000352431-21221089_10921115.33333333333331161.0Compositional biasNote=Poly-Ser
HgeneZMYND8chr20:45848908chr22:39111911ENST00000352431-212243_471115.33333333333331161.0Compositional biasNote=Poly-Lys
HgeneZMYND8chr20:45848908chr22:39111911ENST00000352431-2122838_8541115.33333333333331161.0Compositional biasNote=Poly-Gln
HgeneZMYND8chr20:45848908chr22:39111911ENST00000355972-22241089_10921141.33333333333331215.0Compositional biasNote=Poly-Ser
HgeneZMYND8chr20:45848908chr22:39111911ENST00000355972-222443_471141.33333333333331215.0Compositional biasNote=Poly-Lys
HgeneZMYND8chr20:45848908chr22:39111911ENST00000355972-2224838_8541141.33333333333331215.0Compositional biasNote=Poly-Gln
HgeneZMYND8chr20:45848908chr22:39111911ENST00000360911-21221089_10921090.33333333333331136.0Compositional biasNote=Poly-Ser
HgeneZMYND8chr20:45848908chr22:39111911ENST00000360911-212243_471090.33333333333331136.0Compositional biasNote=Poly-Lys
HgeneZMYND8chr20:45848908chr22:39111911ENST00000360911-2122838_8541090.33333333333331136.0Compositional biasNote=Poly-Gln
HgeneZMYND8chr20:45848908chr22:39111911ENST00000461685-21231089_10921115.33333333333331189.0Compositional biasNote=Poly-Ser
HgeneZMYND8chr20:45848908chr22:39111911ENST00000461685-212343_471115.33333333333331189.0Compositional biasNote=Poly-Lys
HgeneZMYND8chr20:45848908chr22:39111911ENST00000461685-2123838_8541115.33333333333331189.0Compositional biasNote=Poly-Gln
HgeneZMYND8chr20:45848908chr22:39111911ENST00000471951-21231089_10921161.33333333333331235.0Compositional biasNote=Poly-Ser
HgeneZMYND8chr20:45848908chr22:39111911ENST00000471951-212343_471161.33333333333331235.0Compositional biasNote=Poly-Lys
HgeneZMYND8chr20:45848908chr22:39111911ENST00000471951-2123838_8541161.33333333333331235.0Compositional biasNote=Poly-Gln
HgeneZMYND8chr20:45848909chr22:39111912ENST00000262975-22241089_10921095.33333333333331169.0Compositional biasNote=Poly-Ser
HgeneZMYND8chr20:45848909chr22:39111912ENST00000262975-222443_471095.33333333333331169.0Compositional biasNote=Poly-Lys
HgeneZMYND8chr20:45848909chr22:39111912ENST00000262975-2224838_8541095.33333333333331169.0Compositional biasNote=Poly-Gln
HgeneZMYND8chr20:45848909chr22:39111912ENST00000311275-21221089_10921141.33333333333331187.0Compositional biasNote=Poly-Ser
HgeneZMYND8chr20:45848909chr22:39111912ENST00000311275-212243_471141.33333333333331187.0Compositional biasNote=Poly-Lys
HgeneZMYND8chr20:45848909chr22:39111912ENST00000311275-2122838_8541141.33333333333331187.0Compositional biasNote=Poly-Gln
HgeneZMYND8chr20:45848909chr22:39111912ENST00000352431-21221089_10921115.33333333333331161.0Compositional biasNote=Poly-Ser
HgeneZMYND8chr20:45848909chr22:39111912ENST00000352431-212243_471115.33333333333331161.0Compositional biasNote=Poly-Lys
HgeneZMYND8chr20:45848909chr22:39111912ENST00000352431-2122838_8541115.33333333333331161.0Compositional biasNote=Poly-Gln
HgeneZMYND8chr20:45848909chr22:39111912ENST00000355972-22241089_10921141.33333333333331215.0Compositional biasNote=Poly-Ser
HgeneZMYND8chr20:45848909chr22:39111912ENST00000355972-222443_471141.33333333333331215.0Compositional biasNote=Poly-Lys
HgeneZMYND8chr20:45848909chr22:39111912ENST00000355972-2224838_8541141.33333333333331215.0Compositional biasNote=Poly-Gln
HgeneZMYND8chr20:45848909chr22:39111912ENST00000360911-21221089_10921090.33333333333331136.0Compositional biasNote=Poly-Ser
HgeneZMYND8chr20:45848909chr22:39111912ENST00000360911-212243_471090.33333333333331136.0Compositional biasNote=Poly-Lys
HgeneZMYND8chr20:45848909chr22:39111912ENST00000360911-2122838_8541090.33333333333331136.0Compositional biasNote=Poly-Gln
HgeneZMYND8chr20:45848909chr22:39111912ENST00000461685-21231089_10921115.33333333333331189.0Compositional biasNote=Poly-Ser
HgeneZMYND8chr20:45848909chr22:39111912ENST00000461685-212343_471115.33333333333331189.0Compositional biasNote=Poly-Lys
HgeneZMYND8chr20:45848909chr22:39111912ENST00000461685-2123838_8541115.33333333333331189.0Compositional biasNote=Poly-Gln
HgeneZMYND8chr20:45848909chr22:39111912ENST00000471951-21231089_10921161.33333333333331235.0Compositional biasNote=Poly-Ser
HgeneZMYND8chr20:45848909chr22:39111912ENST00000471951-212343_471161.33333333333331235.0Compositional biasNote=Poly-Lys
HgeneZMYND8chr20:45848909chr22:39111912ENST00000471951-2123838_8541161.33333333333331235.0Compositional biasNote=Poly-Gln
HgeneZMYND8chr20:45848908chr22:39111911ENST00000262975-2224165_2351095.33333333333331169.0DomainBromo
HgeneZMYND8chr20:45848908chr22:39111911ENST00000262975-2224277_3271095.33333333333331169.0DomainPWWP
HgeneZMYND8chr20:45848908chr22:39111911ENST00000311275-2122165_2351141.33333333333331187.0DomainBromo
HgeneZMYND8chr20:45848908chr22:39111911ENST00000311275-2122277_3271141.33333333333331187.0DomainPWWP
HgeneZMYND8chr20:45848908chr22:39111911ENST00000352431-2122165_2351115.33333333333331161.0DomainBromo
HgeneZMYND8chr20:45848908chr22:39111911ENST00000352431-2122277_3271115.33333333333331161.0DomainPWWP
HgeneZMYND8chr20:45848908chr22:39111911ENST00000355972-2224165_2351141.33333333333331215.0DomainBromo
HgeneZMYND8chr20:45848908chr22:39111911ENST00000355972-2224277_3271141.33333333333331215.0DomainPWWP
HgeneZMYND8chr20:45848908chr22:39111911ENST00000360911-2122165_2351090.33333333333331136.0DomainBromo
HgeneZMYND8chr20:45848908chr22:39111911ENST00000360911-2122277_3271090.33333333333331136.0DomainPWWP
HgeneZMYND8chr20:45848908chr22:39111911ENST00000461685-2123165_2351115.33333333333331189.0DomainBromo
HgeneZMYND8chr20:45848908chr22:39111911ENST00000461685-2123277_3271115.33333333333331189.0DomainPWWP
HgeneZMYND8chr20:45848908chr22:39111911ENST00000471951-2123165_2351161.33333333333331235.0DomainBromo
HgeneZMYND8chr20:45848908chr22:39111911ENST00000471951-2123277_3271161.33333333333331235.0DomainPWWP
HgeneZMYND8chr20:45848909chr22:39111912ENST00000262975-2224165_2351095.33333333333331169.0DomainBromo
HgeneZMYND8chr20:45848909chr22:39111912ENST00000262975-2224277_3271095.33333333333331169.0DomainPWWP
HgeneZMYND8chr20:45848909chr22:39111912ENST00000311275-2122165_2351141.33333333333331187.0DomainBromo
HgeneZMYND8chr20:45848909chr22:39111912ENST00000311275-2122277_3271141.33333333333331187.0DomainPWWP
HgeneZMYND8chr20:45848909chr22:39111912ENST00000352431-2122165_2351115.33333333333331161.0DomainBromo
HgeneZMYND8chr20:45848909chr22:39111912ENST00000352431-2122277_3271115.33333333333331161.0DomainPWWP
HgeneZMYND8chr20:45848909chr22:39111912ENST00000355972-2224165_2351141.33333333333331215.0DomainBromo
HgeneZMYND8chr20:45848909chr22:39111912ENST00000355972-2224277_3271141.33333333333331215.0DomainPWWP
HgeneZMYND8chr20:45848909chr22:39111912ENST00000360911-2122165_2351090.33333333333331136.0DomainBromo
HgeneZMYND8chr20:45848909chr22:39111912ENST00000360911-2122277_3271090.33333333333331136.0DomainPWWP
HgeneZMYND8chr20:45848909chr22:39111912ENST00000461685-2123165_2351115.33333333333331189.0DomainBromo
HgeneZMYND8chr20:45848909chr22:39111912ENST00000461685-2123277_3271115.33333333333331189.0DomainPWWP
HgeneZMYND8chr20:45848909chr22:39111912ENST00000471951-2123165_2351161.33333333333331235.0DomainBromo
HgeneZMYND8chr20:45848909chr22:39111912ENST00000471951-2123277_3271161.33333333333331235.0DomainPWWP
HgeneZMYND8chr20:45848908chr22:39111911ENST00000262975-22241028_10621095.33333333333331169.0Zinc fingerMYND-type
HgeneZMYND8chr20:45848908chr22:39111911ENST00000262975-222488_1331095.33333333333331169.0Zinc fingerPHD-type
HgeneZMYND8chr20:45848908chr22:39111911ENST00000311275-21221028_10621141.33333333333331187.0Zinc fingerMYND-type
HgeneZMYND8chr20:45848908chr22:39111911ENST00000311275-212288_1331141.33333333333331187.0Zinc fingerPHD-type
HgeneZMYND8chr20:45848908chr22:39111911ENST00000352431-21221028_10621115.33333333333331161.0Zinc fingerMYND-type
HgeneZMYND8chr20:45848908chr22:39111911ENST00000352431-212288_1331115.33333333333331161.0Zinc fingerPHD-type
HgeneZMYND8chr20:45848908chr22:39111911ENST00000355972-22241028_10621141.33333333333331215.0Zinc fingerMYND-type
HgeneZMYND8chr20:45848908chr22:39111911ENST00000355972-222488_1331141.33333333333331215.0Zinc fingerPHD-type
HgeneZMYND8chr20:45848908chr22:39111911ENST00000360911-21221028_10621090.33333333333331136.0Zinc fingerMYND-type
HgeneZMYND8chr20:45848908chr22:39111911ENST00000360911-212288_1331090.33333333333331136.0Zinc fingerPHD-type
HgeneZMYND8chr20:45848908chr22:39111911ENST00000461685-21231028_10621115.33333333333331189.0Zinc fingerMYND-type
HgeneZMYND8chr20:45848908chr22:39111911ENST00000461685-212388_1331115.33333333333331189.0Zinc fingerPHD-type
HgeneZMYND8chr20:45848908chr22:39111911ENST00000471951-21231028_10621161.33333333333331235.0Zinc fingerMYND-type
HgeneZMYND8chr20:45848908chr22:39111911ENST00000471951-212388_1331161.33333333333331235.0Zinc fingerPHD-type
HgeneZMYND8chr20:45848909chr22:39111912ENST00000262975-22241028_10621095.33333333333331169.0Zinc fingerMYND-type
HgeneZMYND8chr20:45848909chr22:39111912ENST00000262975-222488_1331095.33333333333331169.0Zinc fingerPHD-type
HgeneZMYND8chr20:45848909chr22:39111912ENST00000311275-21221028_10621141.33333333333331187.0Zinc fingerMYND-type
HgeneZMYND8chr20:45848909chr22:39111912ENST00000311275-212288_1331141.33333333333331187.0Zinc fingerPHD-type
HgeneZMYND8chr20:45848909chr22:39111912ENST00000352431-21221028_10621115.33333333333331161.0Zinc fingerMYND-type
HgeneZMYND8chr20:45848909chr22:39111912ENST00000352431-212288_1331115.33333333333331161.0Zinc fingerPHD-type
HgeneZMYND8chr20:45848909chr22:39111912ENST00000355972-22241028_10621141.33333333333331215.0Zinc fingerMYND-type
HgeneZMYND8chr20:45848909chr22:39111912ENST00000355972-222488_1331141.33333333333331215.0Zinc fingerPHD-type
HgeneZMYND8chr20:45848909chr22:39111912ENST00000360911-21221028_10621090.33333333333331136.0Zinc fingerMYND-type
HgeneZMYND8chr20:45848909chr22:39111912ENST00000360911-212288_1331090.33333333333331136.0Zinc fingerPHD-type
HgeneZMYND8chr20:45848909chr22:39111912ENST00000461685-21231028_10621115.33333333333331189.0Zinc fingerMYND-type
HgeneZMYND8chr20:45848909chr22:39111912ENST00000461685-212388_1331115.33333333333331189.0Zinc fingerPHD-type
HgeneZMYND8chr20:45848909chr22:39111912ENST00000471951-21231028_10621161.33333333333331235.0Zinc fingerMYND-type
HgeneZMYND8chr20:45848909chr22:39111912ENST00000471951-212388_1331161.33333333333331235.0Zinc fingerPHD-type
TgeneGTPBP1chr20:45848908chr22:39111911ENST00000216044112158_389101.33333333333333670.0Domaintr-type G
TgeneGTPBP1chr20:45848909chr22:39111912ENST00000216044112158_389101.33333333333333670.0Domaintr-type G
TgeneGTPBP1chr20:45848908chr22:39111911ENST00000216044112252_256101.33333333333333670.0Nucleotide bindingGTP
TgeneGTPBP1chr20:45848909chr22:39111912ENST00000216044112252_256101.33333333333333670.0Nucleotide bindingGTP
TgeneGTPBP1chr20:45848908chr22:39111911ENST00000216044112167_174101.33333333333333670.0RegionG1
TgeneGTPBP1chr20:45848908chr22:39111911ENST00000216044112206_210101.33333333333333670.0RegionG2
TgeneGTPBP1chr20:45848908chr22:39111911ENST00000216044112252_255101.33333333333333670.0RegionG3
TgeneGTPBP1chr20:45848908chr22:39111911ENST00000216044112308_311101.33333333333333670.0RegionG4
TgeneGTPBP1chr20:45848908chr22:39111911ENST00000216044112366_368101.33333333333333670.0RegionG5
TgeneGTPBP1chr20:45848909chr22:39111912ENST00000216044112167_174101.33333333333333670.0RegionG1
TgeneGTPBP1chr20:45848909chr22:39111912ENST00000216044112206_210101.33333333333333670.0RegionG2
TgeneGTPBP1chr20:45848909chr22:39111912ENST00000216044112252_255101.33333333333333670.0RegionG3
TgeneGTPBP1chr20:45848909chr22:39111912ENST00000216044112308_311101.33333333333333670.0RegionG4
TgeneGTPBP1chr20:45848909chr22:39111912ENST00000216044112366_368101.33333333333333670.0RegionG5

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneGTPBP1chr20:45848908chr22:39111911ENST0000021604411228_36101.33333333333333670.0Compositional biasNote=Poly-Ala
TgeneGTPBP1chr20:45848909chr22:39111912ENST0000021604411228_36101.33333333333333670.0Compositional biasNote=Poly-Ala


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
ZMYND8_pLDDT.png
all structure
all structure
GTPBP1_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
ZMYND8
GTPBP1


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneZMYND8chr20:45848908chr22:39111911ENST00000262975-22241147_11861095.33333333333331169.0PRKCB1
HgeneZMYND8chr20:45848908chr22:39111911ENST00000311275-21221147_11861141.33333333333331187.0PRKCB1
HgeneZMYND8chr20:45848908chr22:39111911ENST00000352431-21221147_11861115.33333333333331161.0PRKCB1
HgeneZMYND8chr20:45848908chr22:39111911ENST00000355972-22241147_11861141.33333333333331215.0PRKCB1
HgeneZMYND8chr20:45848908chr22:39111911ENST00000360911-21221147_11861090.33333333333331136.0PRKCB1
HgeneZMYND8chr20:45848908chr22:39111911ENST00000461685-21231147_11861115.33333333333331189.0PRKCB1
HgeneZMYND8chr20:45848908chr22:39111911ENST00000471951-21231147_11861161.33333333333331235.0PRKCB1
HgeneZMYND8chr20:45848909chr22:39111912ENST00000262975-22241147_11861095.33333333333331169.0PRKCB1
HgeneZMYND8chr20:45848909chr22:39111912ENST00000311275-21221147_11861141.33333333333331187.0PRKCB1
HgeneZMYND8chr20:45848909chr22:39111912ENST00000352431-21221147_11861115.33333333333331161.0PRKCB1
HgeneZMYND8chr20:45848909chr22:39111912ENST00000355972-22241147_11861141.33333333333331215.0PRKCB1
HgeneZMYND8chr20:45848909chr22:39111912ENST00000360911-21221147_11861090.33333333333331136.0PRKCB1
HgeneZMYND8chr20:45848909chr22:39111912ENST00000461685-21231147_11861115.33333333333331189.0PRKCB1
HgeneZMYND8chr20:45848909chr22:39111912ENST00000471951-21231147_11861161.33333333333331235.0PRKCB1


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Related Drugs to ZMYND8-GTPBP1


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to ZMYND8-GTPBP1


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource