UTHEALTH HOME    ABOUT SBMI    A-Z    WEBMAIL    INSIDE THE UNIVERSITY
FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Terms of Use
Center for Computational Systems Medicine level1
leaf

Fusion Gene Summary

leaf

Fusion Gene Sample Information

leaf

Fusion ORF Analysis

leaf

Fusion Amino Acid Sequences

leaf

Fusion Protein Functional Features

leaf

Fusion Protein-Protein Interaction

leaf

Related drugs with this fusion protein

leaf

Related disease with this fusion protein

Fusion Protein:ZMYND8-TFE3

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: ZMYND8-TFE3
FusionPDB ID: 101420
FusionGDB2.0 ID: 101420
HgeneTgene
Gene symbol

ZMYND8

TFE3

Gene ID

23613

7030

Gene namezinc finger MYND-type containing 8transcription factor binding to IGHM enhancer 3
SynonymsPRKCBP1|PRO2893|RACK7RCCP2|RCCX1|TFEA|bHLHe33
Cytomap

20q13.12

Xp11.23

Type of geneprotein-codingprotein-coding
Descriptionprotein kinase C-binding protein 1CTCL tumor antigen se14-3cutaneous T-cell lymphoma-associated antigen se14-3predicted protein of HQ2893zinc finger MYND domain-containing protein 8transcription factor E3class E basic helix-loop-helix protein 33transcription factor E family, member Atranscription factor for IgH enhancertranscription factor for immunoglobulin heavy-chain enhancer 3
Modification date2020031320200327
UniProtAcc.

P19532

Ensembl transtripts involved in fusion geneENST idsENST00000262975, ENST00000311275, 
ENST00000352431, ENST00000355972, 
ENST00000360911, ENST00000372023, 
ENST00000396281, ENST00000446994, 
ENST00000458360, ENST00000461685, 
ENST00000471951, ENST00000536340, 
ENST00000540497, ENST00000468376, 
ENST00000487451, ENST00000315869, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score25 X 23 X 10=575014 X 15 X 6=1260
# samples 3415
** MAII scorelog2(34/5750*10)=-4.0799553045814
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(15/1260*10)=-3.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: ZMYND8 [Title/Abstract] AND TFE3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)ZMYND8(45849965)-TFE3(48896935), # samples:2
Anticipated loss of major functional domain due to fusion event.ZMYND8-TFE3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ZMYND8-TFE3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ZMYND8-TFE3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ZMYND8-TFE3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ZMYND8-TFE3 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
ZMYND8-TFE3 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
ZMYND8-TFE3 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
ZMYND8-TFE3 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
ZMYND8-TFE3 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
ZMYND8-TFE3 seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across ZMYND8 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across TFE3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


Top

Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4UCECTCGA-B5-A3FB-01AZMYND8chr20

45849965

-TFE3chrX

48896935

-


Top

Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000262975ZMYND8chr2045849965-ENST00000315869TFE3chrX48896935-6428350323936671142
ENST00000446994ZMYND8chr2045849965-ENST00000315869TFE3chrX48896935-604431194432831079
ENST00000355972ZMYND8chr2045849965-ENST00000315869TFE3chrX48896935-6442351711536811188

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000262975ENST00000315869ZMYND8chr2045849965-TFE3chrX48896935-0.0035321430.9964678
ENST00000446994ENST00000315869ZMYND8chr2045849965-TFE3chrX48896935-0.0029775210.99702245
ENST00000355972ENST00000315869ZMYND8chr2045849965-TFE3chrX48896935-0.0040380850.99596196

Top

Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>101420_101420_1_ZMYND8-TFE3_ZMYND8_chr20_45849965_ENST00000262975_TFE3_chrX_48896935_ENST00000315869_length(amino acids)=1142AA_BP=1088
MAEEEIKTEQEVVEGMDISTRSKDPGSAERTAQKRKFPSPPHSSNGHSPQDTSTSPIKKKKKPGLLNSNNKEQSELRHGPFYYMKQPLTT
DPVDVVPQDGRNDFYCWVCHREGQVLCCELCPRVYHAKCLRLTSEPEGDWFCPECEKITVAECIETQSKAMTMLTIEQLSYLLKFAIQKM
KQPGTDAFQKPVPLEQHPDYAEYIFHPMDLCTLEKNAKKKMYGCTEAFLADAKWILHNCIIYNGGNHKLTQIAKVVIKICEHEMNEIEVC
PECYLAACQKRDNWFCEPCSNPHPLVWAKLKGFPFWPAKALRDKDGQVDARFFGQHDRAWVPINNCYLMSKEIPFSVKKTKSIFNSAMQE
MEVYVENIRRKFGVFNYSPFRTPYTPNSQYQMLLDPTNPSAGTAKIDKQEKVKLNFDMTASPKILMSKPVLSGGTGRRISLSDMPRSPMS
TNSSVHTGSDVEQDAEKKATSSHFSASEESMDFLDKSTASPASTKTGQAGSLSGSPKPFSPQLSAPITTKTDKTSTTGSILNLNLDRSKA
EMDLKELSESVQQQSTPVPLISPKRQIRSRFQLNLDKTIESCKAQLGINEISEDVYTAVEHSDSEDSEKSDSSDSEYISDDEQKSKNEPE
DTEDKEGCQMDKEPSAVKKKPKPTNPVEIKEELKSTSPASEKADPGAVKDKASPEPEKDFSEKAKPSPHPIKDKLKGKDETDSPTVHLGL
DSDSESELVIDLGEDHSGREGRKNKKEPKEPSPKQDVVGKTPPSTTVGSHSPPETPVLTRSSAQTSAAGATATTSTSSTVTVTAPAPAAT
GSPVKKQRPLLPKETAPAVQRVVWNSSTVQQKEITQSPSTSTITLVTSTQSSPLVTSSGSMSTLVSSVNADLPIATASADVAADIAKYTS
KMMDAIKGTMTEIYNDLSKNTTGSTIAEIRRLRIEIEKLQWLHQQELSEMKHNLELTMAEMRQSLEQERDRLIAEVKKQLELEKQQAVDE
TKKKQWCANCKKEAIFYCCWNTSYCDYPCQQAHWPEHMKSCTQSATAPQQEADAEVNTETLNKSSQGSSSSTQSAPSETASASKEKETSA

--------------------------------------------------------------

>101420_101420_2_ZMYND8-TFE3_ZMYND8_chr20_45849965_ENST00000355972_TFE3_chrX_48896935_ENST00000315869_length(amino acids)=1188AA_BP=1134
MAEEEIKTEQEVVEGMDISTRSKDPGSAERTAQKRKFPSPPHSSNGHSPQDTSTSPIKKKKKPGLLNSNNKEQSELRHGPFYYMKQPLTT
DPVDVVPQDGRNDFYCWVCHREGQVLCCELCPRVYHAKCLRLTSEPEGDWFCPECEKITVAECIETQSKAMTMLTIEQLSYLLKFAIQKM
KQPGTDAFQKPVPLEQHPDYAEYIFHPMDLCTLEKNAKKKMYGCTEAFLADAKWILHNCIIYNGGNHKLTQIAKVVIKICEHEMNEIEVC
PECYLAACQKRDNWFCEPCSNPHPLVWAKLKGFPFWPAKALRDKDGQVDARFFGQHDRAWVPINNCYLMSKEIPFSVKKTKSIFNSAMQE
MEVYVENIRRKFGVFNYSPFRTPYTPNSQYQMLLDPTNPSAGTAKIDKQEKVKLNFDMTASPKILMSKPVLSGGTGRRISLSDMPRSPMS
TNSSVHTGSDVEQDAEKKATSSHFSASEESMDFLDKSTASPASTKTGQAGSLSGSPKPFSPQLSAPITTKTDKTSTTGSILNLNLDRSKA
EMDLKELSESVQQQSTPVPLISPKRQIRSRFQLNLDKTIESCKAQLGINEISEDVYTAVEHSDSEDSEKSDSSDSEYISDDEQKSKNEPE
DTEDKEGCQMDKEPSAVKKKPKPTNPVEIKEELKSTSPASEKADPGAVKDKASPEPEKDFSEKAKPSPHPIKDKLKGKDETDSPTVHLGL
DSDSESELVIDLGEDHSGREGRKNKKEPKEPSPKQDVVGKTPPSTTVGSHSPPETPVLTRSSAQTSAAGATATTSTSSTVTVTAPAPAAT
GSPVKKQRPLLPKETAPAVQRVVWNSSSKFQTSSQKWHMQKMQRQQQQQQQQNQQQQPQSSQGTRYQTRQAVKAVQQKEITQSPSTSTIT
LVTSTQSSPLVTSSGSMSTLVSSVNADLPIATASADVAADIAKYTSKMMDAIKGTMTEIYNDLSKNTTGSTIAEIRRLRIEIEKLQWLHQ
QELSEMKHNLELTMAEMRQSLEQERDRLIAEVKKQLELEKQQAVDETKKKQWCANCKKEAIFYCCWNTSYCDYPCQQAHWPEHMKSCTQS
ATAPQQEADAEVNTETLNKSSQGSSSSTQSAPSETASASKEKETSAEKSKESGSPPNITAGHTSHPSYTLCIVFCRGLQDPCHVVIFFIE

--------------------------------------------------------------

>101420_101420_3_ZMYND8-TFE3_ZMYND8_chr20_45849965_ENST00000446994_TFE3_chrX_48896935_ENST00000315869_length(amino acids)=1079AA_BP=1025
MAEEEIKTEQEVVEGMDISTRSKDPGSAERTAQKRKFPSPPHSSNGHSPQDTSTSPIKKKKKPGLLNSNNKEQDGRNDFYCWVCHREGQV
LCCELCPRVYHAKCLRLTSEPEGDWFCPECETDAFQKPVPLEQHPDYAEYIFHPMDLCTLEKNAKKKMYGCTEAFLADAKWILHNCIIYN
GGNHKLTQIAKVVIKICEHEMNEIEVCPECYLAACQKRDNWFCEPCSNPHPLVWAKLKGFPFWPAKALRDKDGQVDARFFGQHDRAWVPI
NNCYLMSKEIPFSVKKTKSIFNSAMQEMEVYVENIRRKFGVFNYSPFRTPYTPNSQYQMLLDPTNPSAGTAKIDKQEKVKLNFDMTASPK
ILMSKPVLSGGTGRRISLSDMPRSPMSTNSSVHTGSDVEQDAEKKATSSHFSASEESMDFLDKSTASPASTKTGQAGSLSGSPKPFSPQL
SAPITTKTDKTSTTGSILNLNLDRSKAEMDLKELSESVQQQSTPVPLISPKRQIRSRFQLNLDKTIESCKAQLGINEISEDVYTAVEHSD
SEDSEKSDSSDSEYISDDEQKSKNEPEDTEDKEGCQMDKEPSAVKKKPKPTNPVEIKEELKSTSPASEKADPGAVKDKASPEPEKDFSEK
AKPSPHPIKDKLKGKDETDSPTVHLGLDSDSESELVIDLGEDHSGREGRKNKKEPKEPSPKQDVVGKTPPSTTVGSHSPPETPVLTRSSA
QTSAAGATATTSTSSTVTVTAPAPAATGSPVKKQRPLLPKETAPAVQRVVWNSSTVQQKEITQSPSTSTITLVTSTQSSPLVTSSGSMST
LVSSVNADLPIATASADVAADIAKYTSKMMDAIKGTMTEIYNDLSKNTTGSTIAEIRRLRIEIEKLQWLHQQELSEMKHNLELTMAEMRQ
SLEQERDRLIAEVKKQLELEKQQAVDETKKKQWCANCKKEAIFYCCWNTSYCDYPCQQAHWPEHMKSCTQSATAPQQEADAEVNTETLNK

--------------------------------------------------------------

Top

Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr20:45849965/chrX:48896935)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.TFE3

P19532

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Transcription factor that acts as a master regulator of lysosomal biogenesis and immune response (PubMed:2338243, PubMed:29146937, PubMed:30733432, PubMed:31672913). Specifically recognizes and binds E-box sequences (5'-CANNTG-3'); efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFEB or MITF (By similarity). Involved in the cellular response to amino acid availability by acting downstream of MTOR: in the presence of nutrients, TFE3 phosphorylation by MTOR promotes its cytosolic retention and subsequent inactivation (PubMed:31672913). Upon starvation or lysosomal stress, inhibition of MTOR induces TFE3 dephosphorylation, resulting in nuclear localization and transcription factor activity (PubMed:31672913). In association with TFEB, activates the expression of CD40L in T-cells, thereby playing a role in T-cell-dependent antibody responses in activated CD4(+) T-cells and thymus-dependent humoral immunity (By similarity). Specifically recognizes the MUE3 box, a subset of E-boxes, present in the immunoglobulin enhancer (PubMed:2338243). It also binds very well to a USF/MLTF site (PubMed:2338243). May regulate lysosomal positioning in response to nutrient deprivation by promoting the expression of PIP4P1 (PubMed:29146937). Acts as a positive regulator of browning of adipose tissue by promoting expression of target genes; mTOR-dependent phosphorylation promotes cytoplasmic retention of TFE3 and inhibits browning of adipose tissue (By similarity). Maintains the pluripotent state of embryonic stem cells by promoting the expression of genes such as ESRRB; mTOR-dependent nuclear exclusion promotes exit from pluripotency (By similarity). Required to maintain the naive pluripotent state of hematopoietic stem cell; mTOR-dependent cytoplasmic retention of TFE3 promotes the exit of hematopoietic stem cell from pluripotency (PubMed:30733432). {ECO:0000250|UniProtKB:Q64092, ECO:0000269|PubMed:2338243, ECO:0000269|PubMed:29146937, ECO:0000269|PubMed:30733432, ECO:0000269|PubMed:31672913}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneZMYND8chr20:45849965chrX:48896935ENST00000262975-212443_471073.01169.0Compositional biasNote=Poly-Lys
HgeneZMYND8chr20:45849965chrX:48896935ENST00000262975-2124838_8541073.01169.0Compositional biasNote=Poly-Gln
HgeneZMYND8chr20:45849965chrX:48896935ENST00000311275-20221089_10921119.01187.0Compositional biasNote=Poly-Ser
HgeneZMYND8chr20:45849965chrX:48896935ENST00000311275-202243_471119.01187.0Compositional biasNote=Poly-Lys
HgeneZMYND8chr20:45849965chrX:48896935ENST00000311275-2022838_8541119.01187.0Compositional biasNote=Poly-Gln
HgeneZMYND8chr20:45849965chrX:48896935ENST00000352431-20221089_10921093.01161.0Compositional biasNote=Poly-Ser
HgeneZMYND8chr20:45849965chrX:48896935ENST00000352431-202243_471093.01161.0Compositional biasNote=Poly-Lys
HgeneZMYND8chr20:45849965chrX:48896935ENST00000352431-2022838_8541093.01161.0Compositional biasNote=Poly-Gln
HgeneZMYND8chr20:45849965chrX:48896935ENST00000355972-21241089_10921119.01215.0Compositional biasNote=Poly-Ser
HgeneZMYND8chr20:45849965chrX:48896935ENST00000355972-212443_471119.01215.0Compositional biasNote=Poly-Lys
HgeneZMYND8chr20:45849965chrX:48896935ENST00000355972-2124838_8541119.01215.0Compositional biasNote=Poly-Gln
HgeneZMYND8chr20:45849965chrX:48896935ENST00000360911-202243_471068.01136.0Compositional biasNote=Poly-Lys
HgeneZMYND8chr20:45849965chrX:48896935ENST00000360911-2022838_8541068.01136.0Compositional biasNote=Poly-Gln
HgeneZMYND8chr20:45849965chrX:48896935ENST00000461685-20231089_10921093.01189.0Compositional biasNote=Poly-Ser
HgeneZMYND8chr20:45849965chrX:48896935ENST00000461685-202343_471093.01189.0Compositional biasNote=Poly-Lys
HgeneZMYND8chr20:45849965chrX:48896935ENST00000461685-2023838_8541093.01189.0Compositional biasNote=Poly-Gln
HgeneZMYND8chr20:45849965chrX:48896935ENST00000471951-20231089_10921139.01235.0Compositional biasNote=Poly-Ser
HgeneZMYND8chr20:45849965chrX:48896935ENST00000471951-202343_471139.01235.0Compositional biasNote=Poly-Lys
HgeneZMYND8chr20:45849965chrX:48896935ENST00000471951-2023838_8541139.01235.0Compositional biasNote=Poly-Gln
HgeneZMYND8chr20:45849965chrX:48896935ENST00000262975-2124165_2351073.01169.0DomainBromo
HgeneZMYND8chr20:45849965chrX:48896935ENST00000262975-2124277_3271073.01169.0DomainPWWP
HgeneZMYND8chr20:45849965chrX:48896935ENST00000311275-2022165_2351119.01187.0DomainBromo
HgeneZMYND8chr20:45849965chrX:48896935ENST00000311275-2022277_3271119.01187.0DomainPWWP
HgeneZMYND8chr20:45849965chrX:48896935ENST00000352431-2022165_2351093.01161.0DomainBromo
HgeneZMYND8chr20:45849965chrX:48896935ENST00000352431-2022277_3271093.01161.0DomainPWWP
HgeneZMYND8chr20:45849965chrX:48896935ENST00000355972-2124165_2351119.01215.0DomainBromo
HgeneZMYND8chr20:45849965chrX:48896935ENST00000355972-2124277_3271119.01215.0DomainPWWP
HgeneZMYND8chr20:45849965chrX:48896935ENST00000360911-2022165_2351068.01136.0DomainBromo
HgeneZMYND8chr20:45849965chrX:48896935ENST00000360911-2022277_3271068.01136.0DomainPWWP
HgeneZMYND8chr20:45849965chrX:48896935ENST00000461685-2023165_2351093.01189.0DomainBromo
HgeneZMYND8chr20:45849965chrX:48896935ENST00000461685-2023277_3271093.01189.0DomainPWWP
HgeneZMYND8chr20:45849965chrX:48896935ENST00000471951-2023165_2351139.01235.0DomainBromo
HgeneZMYND8chr20:45849965chrX:48896935ENST00000471951-2023277_3271139.01235.0DomainPWWP
HgeneZMYND8chr20:45849965chrX:48896935ENST00000262975-21241028_10621073.01169.0Zinc fingerMYND-type
HgeneZMYND8chr20:45849965chrX:48896935ENST00000262975-212488_1331073.01169.0Zinc fingerPHD-type
HgeneZMYND8chr20:45849965chrX:48896935ENST00000311275-20221028_10621119.01187.0Zinc fingerMYND-type
HgeneZMYND8chr20:45849965chrX:48896935ENST00000311275-202288_1331119.01187.0Zinc fingerPHD-type
HgeneZMYND8chr20:45849965chrX:48896935ENST00000352431-20221028_10621093.01161.0Zinc fingerMYND-type
HgeneZMYND8chr20:45849965chrX:48896935ENST00000352431-202288_1331093.01161.0Zinc fingerPHD-type
HgeneZMYND8chr20:45849965chrX:48896935ENST00000355972-21241028_10621119.01215.0Zinc fingerMYND-type
HgeneZMYND8chr20:45849965chrX:48896935ENST00000355972-212488_1331119.01215.0Zinc fingerPHD-type
HgeneZMYND8chr20:45849965chrX:48896935ENST00000360911-20221028_10621068.01136.0Zinc fingerMYND-type
HgeneZMYND8chr20:45849965chrX:48896935ENST00000360911-202288_1331068.01136.0Zinc fingerPHD-type
HgeneZMYND8chr20:45849965chrX:48896935ENST00000461685-20231028_10621093.01189.0Zinc fingerMYND-type
HgeneZMYND8chr20:45849965chrX:48896935ENST00000461685-202388_1331093.01189.0Zinc fingerPHD-type
HgeneZMYND8chr20:45849965chrX:48896935ENST00000471951-20231028_10621139.01235.0Zinc fingerMYND-type
HgeneZMYND8chr20:45849965chrX:48896935ENST00000471951-202388_1331139.01235.0Zinc fingerPHD-type
TgeneTFE3chr20:45849965chrX:48896935ENST00000315869110346_39976.66666666666667576.0DomainbHLH
TgeneTFE3chr20:45849965chrX:48896935ENST00000315869110260_27176.66666666666667576.0RegionStrong transcription activation domain
TgeneTFE3chr20:45849965chrX:48896935ENST00000315869110409_43076.66666666666667576.0RegionNote=Leucine-zipper

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneZMYND8chr20:45849965chrX:48896935ENST00000262975-21241089_10921073.01169.0Compositional biasNote=Poly-Ser
HgeneZMYND8chr20:45849965chrX:48896935ENST00000360911-20221089_10921068.01136.0Compositional biasNote=Poly-Ser


Top

Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors
TFE3AKR1B1, CLTC, PHB2, ACLY, CUL2, EPRS, PFAS, VARS, NEDD8, RPL38, TRIM28, EIF3A, RPA3, E2F3, SMARCE1, MITF, TFE3, SMAD3, SMAD4, TFEC, EWSR1, XPO1, TFEB, Arrb2, TARDBP, HIST1H4A, LAMTOR3, nsp2, nsp7, AIM2, NR3C1, DDX58, YWHAG, YWHAQ, HDAC5, BTF3, nsp16, IRF8, KLF12, KLF16, KLF3, KLF5, KLF8, SOX2, TLX3, VSX1,


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
ZMYND8
TFE3all structure


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneZMYND8chr20:45849965chrX:48896935ENST00000262975-21241147_11861073.01169.0PRKCB1
HgeneZMYND8chr20:45849965chrX:48896935ENST00000311275-20221147_11861119.01187.0PRKCB1
HgeneZMYND8chr20:45849965chrX:48896935ENST00000352431-20221147_11861093.01161.0PRKCB1
HgeneZMYND8chr20:45849965chrX:48896935ENST00000355972-21241147_11861119.01215.0PRKCB1
HgeneZMYND8chr20:45849965chrX:48896935ENST00000360911-20221147_11861068.01136.0PRKCB1
HgeneZMYND8chr20:45849965chrX:48896935ENST00000461685-20231147_11861093.01189.0PRKCB1
HgeneZMYND8chr20:45849965chrX:48896935ENST00000471951-20231147_11861139.01235.0PRKCB1


Top

Related Drugs to ZMYND8-TFE3


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

Top

Related Diseases to ZMYND8-TFE3


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneTFE3C4518356MiT family translocation renal cell carcinoma2ORPHANET
TgeneTFE3C0206657Alveolar Soft Part Sarcoma1ORPHANET
TgeneTFE3C0206732Epithelioid hemangioendothelioma1ORPHANET