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Center for Computational Systems Medicine level2
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:ZNF419-SNRPD2

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: ZNF419-SNRPD2
FusionPDB ID: 102040
FusionGDB2.0 ID: 102040
HgeneTgene
Gene symbol

ZNF419

SNRPD2

Gene ID

79744

6633

Gene namezinc finger protein 419small nuclear ribonucleoprotein D2 polypeptide
SynonymsZAPHIR|ZNF419ASMD2|SNRPD1|Sm-D2
Cytomap

19q13.43

19q13.32

Type of geneprotein-codingprotein-coding
Descriptionzinc finger protein 419zinc finger protein 419Asmall nuclear ribonucleoprotein Sm D2small nuclear ribonucleoprotein D2 polypeptide 16.5kDasnRNP core protein D2
Modification date2020031320200322
UniProtAcc..
Ensembl transtripts involved in fusion geneENST idsENST00000221735, ENST00000347466, 
ENST00000354197, ENST00000415379, 
ENST00000424930, ENST00000426954, 
ENST00000442920, ENST00000518999, 
ENST00000520540, 		ENST00000391932, 
ENST00000585392, ENST00000587367, 
ENST00000588301, ENST00000588599, 
ENST00000590212, ENST00000587579, 
ENST00000342669, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score3 X 2 X 3=1811 X 10 X 4=440
# samples 312
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(12/440*10)=-1.87446911791614
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: ZNF419 [Title/Abstract] AND SNRPD2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)ZNF419(58002965)-SNRPD2(46190985), # samples:2
Anticipated loss of major functional domain due to fusion event.ZNF419-SNRPD2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ZNF419-SNRPD2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneSNRPD2

GO:0000387

spliceosomal snRNP assembly

18984161

TgeneSNRPD2

GO:0000398

mRNA splicing, via spliceosome

28076346


check buttonFusion gene breakpoints across ZNF419 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across SNRPD2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4GBMTCGA-32-1970-01AZNF419chr19

58002965

+SNRPD2chr19

46190985

-
ChimerDB4GBMTCGA-32-1970ZNF419chr19

58002965

+SNRPD2chr19

46190985

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000354197ZNF419chr1958002965+ENST00000342669SNRPD2chr1946190985-67740313243199
ENST00000426954ZNF419chr1958002965+ENST00000342669SNRPD2chr1946190985-67740313243199
ENST00000520540ZNF419chr1958002965+ENST00000342669SNRPD2chr1946190985-67039612542499
ENST00000442920ZNF419chr1958002965+ENST00000342669SNRPD2chr1946190985-66739312542198
ENST00000424930ZNF419chr1958002965+ENST00000342669SNRPD2chr1946190985-705431121459112
ENST00000347466ZNF419chr1958002965+ENST00000342669SNRPD2chr1946190985-686412102440112
ENST00000415379ZNF419chr1958002965+ENST00000342669SNRPD2chr1946190985-6353619338998
ENST00000221735ZNF419chr1958002965+ENST00000342669SNRPD2chr1946190985-65938578413111
ENST00000518999ZNF419chr1958002965+ENST00000342669SNRPD2chr1946190985-65638272410112

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000354197ENST00000342669ZNF419chr1958002965+SNRPD2chr1946190985-0.12852260.8714774
ENST00000426954ENST00000342669ZNF419chr1958002965+SNRPD2chr1946190985-0.12852260.8714774
ENST00000520540ENST00000342669ZNF419chr1958002965+SNRPD2chr1946190985-0.12794710.87205285
ENST00000442920ENST00000342669ZNF419chr1958002965+SNRPD2chr1946190985-0.190862250.80913776
ENST00000424930ENST00000342669ZNF419chr1958002965+SNRPD2chr1946190985-0.0513353830.94866467
ENST00000347466ENST00000342669ZNF419chr1958002965+SNRPD2chr1946190985-0.077715670.92228436
ENST00000415379ENST00000342669ZNF419chr1958002965+SNRPD2chr1946190985-0.154127120.84587294
ENST00000221735ENST00000342669ZNF419chr1958002965+SNRPD2chr1946190985-0.0459728130.9540271
ENST00000518999ENST00000342669ZNF419chr1958002965+SNRPD2chr1946190985-0.0450855270.9549145

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>102040_102040_1_ZNF419-SNRPD2_ZNF419_chr19_58002965_ENST00000221735_SNRPD2_chr19_46190985_ENST00000342669_length(amino acids)=111AA_BP=
MFSPLRGGSEARWRRPGWPGPFPRSLSPLQLYSQAPMAAAALRDPAQVPVAADLLTDHEEGYVTFEDVAVYFSQEEWRLLDDAQRLLYRN

--------------------------------------------------------------

>102040_102040_2_ZNF419-SNRPD2_ZNF419_chr19_58002965_ENST00000347466_SNRPD2_chr19_46190985_ENST00000342669_length(amino acids)=112AA_BP=
MFSPLRGGSEARWRRPGWPGPFPRSLSPLQLYSQAPMAAAALRDPAQVPVAADLLTDHEEQGYVTFEDVAVYFSQEEWRLLDDAQRLLYR

--------------------------------------------------------------

>102040_102040_3_ZNF419-SNRPD2_ZNF419_chr19_58002965_ENST00000354197_SNRPD2_chr19_46190985_ENST00000342669_length(amino acids)=99AA_BP=
MFSPLRGGSEARWRRPGWPGPFPRSLSPLQLYSQAPMAAAALRDPAQQGYVTFEDVAVYFSQEEWRLLDDAQRLLYRNVMLENFTLLASL

--------------------------------------------------------------

>102040_102040_4_ZNF419-SNRPD2_ZNF419_chr19_58002965_ENST00000415379_SNRPD2_chr19_46190985_ENST00000342669_length(amino acids)=98AA_BP=
MFSPLRGGSEARWRRPGWPGPFPRSLSPLQLYSQAPMAAAALRDPAQGYVTFEDVAVYFSQEEWRLLDDAQRLLYRNVMLENFTLLASLG

--------------------------------------------------------------

>102040_102040_5_ZNF419-SNRPD2_ZNF419_chr19_58002965_ENST00000424930_SNRPD2_chr19_46190985_ENST00000342669_length(amino acids)=112AA_BP=
MFSPLRGGSEARWRRPGWPGPFPRSLSPLQLYSQAPMAAAALRDPAQVPVAADLLTDHEEQGYVTFEDVAVYFSQEEWRLLDDAQRLLYR

--------------------------------------------------------------

>102040_102040_6_ZNF419-SNRPD2_ZNF419_chr19_58002965_ENST00000426954_SNRPD2_chr19_46190985_ENST00000342669_length(amino acids)=99AA_BP=
MFSPLRGGSEARWRRPGWPGPFPRSLSPLQLYSQAPMAAAALRDPAQQGYVTFEDVAVYFSQEEWRLLDDAQRLLYRNVMLENFTLLASL

--------------------------------------------------------------

>102040_102040_7_ZNF419-SNRPD2_ZNF419_chr19_58002965_ENST00000442920_SNRPD2_chr19_46190985_ENST00000342669_length(amino acids)=98AA_BP=
MFSPLRGGSEARWRRPGWPGPFPRSLSPLQLYSQAPMAAAALRDPAQGYVTFEDVAVYFSQEEWRLLDDAQRLLYRNVMLENFTLLASLG

--------------------------------------------------------------

>102040_102040_8_ZNF419-SNRPD2_ZNF419_chr19_58002965_ENST00000518999_SNRPD2_chr19_46190985_ENST00000342669_length(amino acids)=112AA_BP=
MFSPLRGGSEARWRRPGWPGPFPRSLSPLQLYSQAPMAAAALRDPAQVPVAADLLTDHEEQGYVTFEDVAVYFSQEEWRLLDDAQRLLYR

--------------------------------------------------------------

>102040_102040_9_ZNF419-SNRPD2_ZNF419_chr19_58002965_ENST00000520540_SNRPD2_chr19_46190985_ENST00000342669_length(amino acids)=99AA_BP=
MFSPLRGGSEARWRRPGWPGPFPRSLSPLQLYSQAPMAAAALRDPAQQGYVTFEDVAVYFSQEEWRLLDDAQRLLYRNVMLENFTLLASL

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:58002965/chr19:46190985)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneZNF419chr19:58002965chr19:46190985ENST00000221735+3527_9866.33333333333333511.0DomainKRAB
HgeneZNF419chr19:58002965chr19:46190985ENST00000347466+3427_9867.33333333333333479.0DomainKRAB
HgeneZNF419chr19:58002965chr19:46190985ENST00000415379+2327_9853.333333333333336465.0DomainKRAB
HgeneZNF419chr19:58002965chr19:46190985ENST00000424930+3527_9867.33333333333333512.0DomainKRAB
HgeneZNF419chr19:58002965chr19:46190985ENST00000426954+2427_9854.333333333333336499.0DomainKRAB
HgeneZNF419chr19:58002965chr19:46190985ENST00000442920+2427_9853.333333333333336498.0DomainKRAB
HgeneZNF419chr19:58002965chr19:46190985ENST00000221735+35203_22566.33333333333333511.0Zinc fingerC2H2-type 1
HgeneZNF419chr19:58002965chr19:46190985ENST00000221735+35231_25366.33333333333333511.0Zinc fingerC2H2-type 2
HgeneZNF419chr19:58002965chr19:46190985ENST00000221735+35259_28166.33333333333333511.0Zinc fingerC2H2-type 3
HgeneZNF419chr19:58002965chr19:46190985ENST00000221735+35287_30966.33333333333333511.0Zinc fingerC2H2-type 4
HgeneZNF419chr19:58002965chr19:46190985ENST00000221735+35315_33766.33333333333333511.0Zinc fingerC2H2-type 5
HgeneZNF419chr19:58002965chr19:46190985ENST00000221735+35343_36566.33333333333333511.0Zinc fingerC2H2-type 6
HgeneZNF419chr19:58002965chr19:46190985ENST00000221735+35371_39366.33333333333333511.0Zinc fingerC2H2-type 7
HgeneZNF419chr19:58002965chr19:46190985ENST00000221735+35399_42166.33333333333333511.0Zinc fingerC2H2-type 8
HgeneZNF419chr19:58002965chr19:46190985ENST00000221735+35427_44966.33333333333333511.0Zinc fingerC2H2-type 9
HgeneZNF419chr19:58002965chr19:46190985ENST00000221735+35455_47766.33333333333333511.0Zinc fingerC2H2-type 10
HgeneZNF419chr19:58002965chr19:46190985ENST00000221735+35483_50566.33333333333333511.0Zinc fingerC2H2-type 11
HgeneZNF419chr19:58002965chr19:46190985ENST00000347466+34203_22567.33333333333333479.0Zinc fingerC2H2-type 1
HgeneZNF419chr19:58002965chr19:46190985ENST00000347466+34231_25367.33333333333333479.0Zinc fingerC2H2-type 2
HgeneZNF419chr19:58002965chr19:46190985ENST00000347466+34259_28167.33333333333333479.0Zinc fingerC2H2-type 3
HgeneZNF419chr19:58002965chr19:46190985ENST00000347466+34287_30967.33333333333333479.0Zinc fingerC2H2-type 4
HgeneZNF419chr19:58002965chr19:46190985ENST00000347466+34315_33767.33333333333333479.0Zinc fingerC2H2-type 5
HgeneZNF419chr19:58002965chr19:46190985ENST00000347466+34343_36567.33333333333333479.0Zinc fingerC2H2-type 6
HgeneZNF419chr19:58002965chr19:46190985ENST00000347466+34371_39367.33333333333333479.0Zinc fingerC2H2-type 7
HgeneZNF419chr19:58002965chr19:46190985ENST00000347466+34399_42167.33333333333333479.0Zinc fingerC2H2-type 8
HgeneZNF419chr19:58002965chr19:46190985ENST00000347466+34427_44967.33333333333333479.0Zinc fingerC2H2-type 9
HgeneZNF419chr19:58002965chr19:46190985ENST00000347466+34455_47767.33333333333333479.0Zinc fingerC2H2-type 10
HgeneZNF419chr19:58002965chr19:46190985ENST00000347466+34483_50567.33333333333333479.0Zinc fingerC2H2-type 11
HgeneZNF419chr19:58002965chr19:46190985ENST00000415379+23203_22553.333333333333336465.0Zinc fingerC2H2-type 1
HgeneZNF419chr19:58002965chr19:46190985ENST00000415379+23231_25353.333333333333336465.0Zinc fingerC2H2-type 2
HgeneZNF419chr19:58002965chr19:46190985ENST00000415379+23259_28153.333333333333336465.0Zinc fingerC2H2-type 3
HgeneZNF419chr19:58002965chr19:46190985ENST00000415379+23287_30953.333333333333336465.0Zinc fingerC2H2-type 4
HgeneZNF419chr19:58002965chr19:46190985ENST00000415379+23315_33753.333333333333336465.0Zinc fingerC2H2-type 5
HgeneZNF419chr19:58002965chr19:46190985ENST00000415379+23343_36553.333333333333336465.0Zinc fingerC2H2-type 6
HgeneZNF419chr19:58002965chr19:46190985ENST00000415379+23371_39353.333333333333336465.0Zinc fingerC2H2-type 7
HgeneZNF419chr19:58002965chr19:46190985ENST00000415379+23399_42153.333333333333336465.0Zinc fingerC2H2-type 8
HgeneZNF419chr19:58002965chr19:46190985ENST00000415379+23427_44953.333333333333336465.0Zinc fingerC2H2-type 9
HgeneZNF419chr19:58002965chr19:46190985ENST00000415379+23455_47753.333333333333336465.0Zinc fingerC2H2-type 10
HgeneZNF419chr19:58002965chr19:46190985ENST00000415379+23483_50553.333333333333336465.0Zinc fingerC2H2-type 11
HgeneZNF419chr19:58002965chr19:46190985ENST00000424930+35203_22567.33333333333333512.0Zinc fingerC2H2-type 1
HgeneZNF419chr19:58002965chr19:46190985ENST00000424930+35231_25367.33333333333333512.0Zinc fingerC2H2-type 2
HgeneZNF419chr19:58002965chr19:46190985ENST00000424930+35259_28167.33333333333333512.0Zinc fingerC2H2-type 3
HgeneZNF419chr19:58002965chr19:46190985ENST00000424930+35287_30967.33333333333333512.0Zinc fingerC2H2-type 4
HgeneZNF419chr19:58002965chr19:46190985ENST00000424930+35315_33767.33333333333333512.0Zinc fingerC2H2-type 5
HgeneZNF419chr19:58002965chr19:46190985ENST00000424930+35343_36567.33333333333333512.0Zinc fingerC2H2-type 6
HgeneZNF419chr19:58002965chr19:46190985ENST00000424930+35371_39367.33333333333333512.0Zinc fingerC2H2-type 7
HgeneZNF419chr19:58002965chr19:46190985ENST00000424930+35399_42167.33333333333333512.0Zinc fingerC2H2-type 8
HgeneZNF419chr19:58002965chr19:46190985ENST00000424930+35427_44967.33333333333333512.0Zinc fingerC2H2-type 9
HgeneZNF419chr19:58002965chr19:46190985ENST00000424930+35455_47767.33333333333333512.0Zinc fingerC2H2-type 10
HgeneZNF419chr19:58002965chr19:46190985ENST00000424930+35483_50567.33333333333333512.0Zinc fingerC2H2-type 11
HgeneZNF419chr19:58002965chr19:46190985ENST00000426954+24203_22554.333333333333336499.0Zinc fingerC2H2-type 1
HgeneZNF419chr19:58002965chr19:46190985ENST00000426954+24231_25354.333333333333336499.0Zinc fingerC2H2-type 2
HgeneZNF419chr19:58002965chr19:46190985ENST00000426954+24259_28154.333333333333336499.0Zinc fingerC2H2-type 3
HgeneZNF419chr19:58002965chr19:46190985ENST00000426954+24287_30954.333333333333336499.0Zinc fingerC2H2-type 4
HgeneZNF419chr19:58002965chr19:46190985ENST00000426954+24315_33754.333333333333336499.0Zinc fingerC2H2-type 5
HgeneZNF419chr19:58002965chr19:46190985ENST00000426954+24343_36554.333333333333336499.0Zinc fingerC2H2-type 6
HgeneZNF419chr19:58002965chr19:46190985ENST00000426954+24371_39354.333333333333336499.0Zinc fingerC2H2-type 7
HgeneZNF419chr19:58002965chr19:46190985ENST00000426954+24399_42154.333333333333336499.0Zinc fingerC2H2-type 8
HgeneZNF419chr19:58002965chr19:46190985ENST00000426954+24427_44954.333333333333336499.0Zinc fingerC2H2-type 9
HgeneZNF419chr19:58002965chr19:46190985ENST00000426954+24455_47754.333333333333336499.0Zinc fingerC2H2-type 10
HgeneZNF419chr19:58002965chr19:46190985ENST00000426954+24483_50554.333333333333336499.0Zinc fingerC2H2-type 11
HgeneZNF419chr19:58002965chr19:46190985ENST00000442920+24203_22553.333333333333336498.0Zinc fingerC2H2-type 1
HgeneZNF419chr19:58002965chr19:46190985ENST00000442920+24231_25353.333333333333336498.0Zinc fingerC2H2-type 2
HgeneZNF419chr19:58002965chr19:46190985ENST00000442920+24259_28153.333333333333336498.0Zinc fingerC2H2-type 3
HgeneZNF419chr19:58002965chr19:46190985ENST00000442920+24287_30953.333333333333336498.0Zinc fingerC2H2-type 4
HgeneZNF419chr19:58002965chr19:46190985ENST00000442920+24315_33753.333333333333336498.0Zinc fingerC2H2-type 5
HgeneZNF419chr19:58002965chr19:46190985ENST00000442920+24343_36553.333333333333336498.0Zinc fingerC2H2-type 6
HgeneZNF419chr19:58002965chr19:46190985ENST00000442920+24371_39353.333333333333336498.0Zinc fingerC2H2-type 7
HgeneZNF419chr19:58002965chr19:46190985ENST00000442920+24399_42153.333333333333336498.0Zinc fingerC2H2-type 8
HgeneZNF419chr19:58002965chr19:46190985ENST00000442920+24427_44953.333333333333336498.0Zinc fingerC2H2-type 9
HgeneZNF419chr19:58002965chr19:46190985ENST00000442920+24455_47753.333333333333336498.0Zinc fingerC2H2-type 10
HgeneZNF419chr19:58002965chr19:46190985ENST00000442920+24483_50553.333333333333336498.0Zinc fingerC2H2-type 11


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file >>>40_ZNF419_58002965_SNRPD2_46190985_ranked_0.pdbZNF4195800296558002965ENST00000342669SNRPD2chr1946190985-
MFSPLRGGSEARWRRPGWPGPFPRSLSPLQLYSQAPMAAAALRDPAQVPVAADLLTDHEEQGYVTFEDVAVYFSQEEWRLLDDAQRLLYR
112


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
ZNF419_pLDDT.png
all structure
all structure
SNRPD2_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
all structure


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
ZNF419
SNRPD2


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to ZNF419-SNRPD2


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to ZNF419-SNRPD2


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource