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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:ZNF420-DPF1

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: ZNF420-DPF1
	FusionPDB ID: 102043
	FusionGDB2.0 ID: 102043
		Hgene	Tgene
	Gene symbol	ZNF420	DPF1
	Gene ID	147923	8193
	Gene name	zinc finger protein 420	double PHD fingers 1
	Synonyms	APAK	BAF45b\|NEUD4\|neuro-d4
	Cytomap	19q13.12	19q13.2
	Type of gene	protein-coding	protein-coding
	Description	zinc finger protein 420ATM and p53-associated KZNF protein	zinc finger protein neuro-d4BRG1-associated factor 45BD4, zinc and double PHD fingers family 1neuro-d4 homolog
	Modification date	20200313	20200313
	UniProtAcc	.	Q92782
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000304239, ENST00000337995, ENST00000586540,	ENST00000355526, ENST00000412732, ENST00000414789, ENST00000416611, ENST00000420980, ENST00000456296,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	8 X 6 X 7=336	9 X 4 X 7=252
	# samples	10	10
	** MAII score	log2(10/336*10)=-1.74846123300404 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(10/252*10)=-1.33342373372519 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: ZNF420 [Title/Abstract] AND DPF1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	ZNF420(37582023)-DPF1(38704396), # samples:5
Anticipated loss of major functional domain due to fusion event.	ZNF420-DPF1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ZNF420-DPF1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ZNF420-DPF1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. ZNF420-DPF1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across ZNF420 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across DPF1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	ESCA	TCGA-XP-A8T6-01A	ZNF420	chr19	37582023	-	DPF1	chr19	38704396	-
ChimerDB4	ESCA	TCGA-XP-A8T6-01A	ZNF420	chr19	37582023	+	DPF1	chr19	38704396	-
ChimerDB4	ESCA	TCGA-XP-A8T6	ZNF420	chr19	37582023	+	DPF1	chr19	38704396	-
ChimerDB4	ESCA	TCGA-XP-A8T6	ZNF420	chr19	37587017	+	DPF1	chr19	38704396	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000304239	ZNF420	chr19	37582023	+	ENST00000420980	DPF1	chr19	38704396	-	1749	396	1604	684	306
ENST00000304239	ZNF420	chr19	37582023	+	ENST00000412732	DPF1	chr19	38704396	-	1716	396	1574	654	306
ENST00000304239	ZNF420	chr19	37582023	+	ENST00000416611	DPF1	chr19	38704396	-	1712	396	1604	684	306
ENST00000304239	ZNF420	chr19	37582023	+	ENST00000414789	DPF1	chr19	38704396	-	1023	396	532	1020	163
ENST00000304239	ZNF420	chr19	37582023	+	ENST00000355526	DPF1	chr19	38704396	-	1022	396	532	1020	163
ENST00000304239	ZNF420	chr19	37582023	+	ENST00000456296	DPF1	chr19	38704396	-	970	396	532	969	146
ENST00000337995	ZNF420	chr19	37582023	+	ENST00000420980	DPF1	chr19	38704396	-	1704	351	1559	639	306
ENST00000337995	ZNF420	chr19	37582023	+	ENST00000412732	DPF1	chr19	38704396	-	1671	351	1529	609	306
ENST00000337995	ZNF420	chr19	37582023	+	ENST00000416611	DPF1	chr19	38704396	-	1667	351	1559	639	306
ENST00000337995	ZNF420	chr19	37582023	+	ENST00000414789	DPF1	chr19	38704396	-	978	351	487	975	163
ENST00000337995	ZNF420	chr19	37582023	+	ENST00000355526	DPF1	chr19	38704396	-	977	351	487	975	163
ENST00000337995	ZNF420	chr19	37582023	+	ENST00000456296	DPF1	chr19	38704396	-	925	351	487	924	146

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000304239	ENST00000420980	ZNF420	chr19	37582023	+	DPF1	chr19	38704396	-	0.28791964	0.7120803
ENST00000304239	ENST00000412732	ZNF420	chr19	37582023	+	DPF1	chr19	38704396	-	0.15809943	0.8419006
ENST00000304239	ENST00000416611	ZNF420	chr19	37582023	+	DPF1	chr19	38704396	-	0.2562389	0.74376106
ENST00000304239	ENST00000414789	ZNF420	chr19	37582023	+	DPF1	chr19	38704396	-	0.068632804	0.93136716
ENST00000304239	ENST00000355526	ZNF420	chr19	37582023	+	DPF1	chr19	38704396	-	0.06753929	0.9324607
ENST00000304239	ENST00000456296	ZNF420	chr19	37582023	+	DPF1	chr19	38704396	-	0.060132477	0.9398675
ENST00000337995	ENST00000420980	ZNF420	chr19	37582023	+	DPF1	chr19	38704396	-	0.27704802	0.72295195
ENST00000337995	ENST00000412732	ZNF420	chr19	37582023	+	DPF1	chr19	38704396	-	0.09364145	0.9063586
ENST00000337995	ENST00000416611	ZNF420	chr19	37582023	+	DPF1	chr19	38704396	-	0.2409298	0.7590702
ENST00000337995	ENST00000414789	ZNF420	chr19	37582023	+	DPF1	chr19	38704396	-	0.06318357	0.9368164
ENST00000337995	ENST00000355526	ZNF420	chr19	37582023	+	DPF1	chr19	38704396	-	0.061973587	0.9380264
ENST00000337995	ENST00000456296	ZNF420	chr19	37582023	+	DPF1	chr19	38704396	-	0.04875519	0.9512448

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>102043_102043_1_ZNF420-DPF1_ZNF420_chr19_37582023_ENST00000304239_DPF1_chr19_38704396_ENST00000355526_length(amino acids)=163AA_BP=
MRSGLPHVLPESPHGGAPGRELELSPLSPAPEGKGFCLHHPHLGRLGSPRLWGGARLPASPSSSILPHPEHPAGGGGEGEAERGLGHPLP

--------------------------------------------------------------

>102043_102043_2_ZNF420-DPF1_ZNF420_chr19_37582023_ENST00000304239_DPF1_chr19_38704396_ENST00000412732_length(amino acids)=306AA_BP=
MQSQFPFFKTRTTNTHNHKKQPRPLTPPKWPARGAGAARPGGAGGGREKESVAESVLLIPAGAGRGPTRPHHRHPPATAGTGRAQAGAVG
EGQEQSSKPRFTSCSIHRGHQEGRVDTTPTALGTRGEGAHLGWGAGRLQLQKLGLGRPAGGRQRRVPGGHSQQRPSTQPGLGGLFVYINF
FSFLLFFFFNFLSFSLEKGSVHAPGWHPPPPMPAQRRGMALRGEAPGVHLPRDREGGREGEALAGPTHPQGRHSTCTEGRGWPSPLSASP

--------------------------------------------------------------

>102043_102043_3_ZNF420-DPF1_ZNF420_chr19_37582023_ENST00000304239_DPF1_chr19_38704396_ENST00000414789_length(amino acids)=163AA_BP=
MRSGLPHVLPESPHGGAPGRELELSPLSPAPEGKGFCLHHPHLGRLGSPRLWGGARLPASPSSSILPHPEHPAGGGGEGEAERGLGHPLP

--------------------------------------------------------------

>102043_102043_4_ZNF420-DPF1_ZNF420_chr19_37582023_ENST00000304239_DPF1_chr19_38704396_ENST00000416611_length(amino acids)=306AA_BP=
MQSQFPFFKTRTTNTHNHKKQPRPLTPPKWPARGAGAARPGGAGGGREKESVAESVLLIPAGAGRGPTRPHHRHPPATAGTGRAQAGAVG
EGQEQSSKPRFTSCSIHRGHQEGRVDTTPTALGTRGEGAHLGWGAGRLQLQKLGLGRPAGGRQRRVPGGHSQQRPSTQPGLGGLFVYINF
FSFLLFFFFNFLSFSLEKGSVHAPGWHPPPPMPAQRRGMALRGEAPGVHLPRDREGGREGEALAGPTHPQGRHSTCTEGRGWPSPLSASP

--------------------------------------------------------------

>102043_102043_5_ZNF420-DPF1_ZNF420_chr19_37582023_ENST00000304239_DPF1_chr19_38704396_ENST00000420980_length(amino acids)=306AA_BP=
MQSQFPFFKTRTTNTHNHKKQPRPLTPPKWPARGAGAARPGGAGGGREKESVAESVLLIPAGAGRGPTRPHHRHPPATAGTGRAQAGAVG
EGQEQSSKPRFTSCSIHRGHQEGRVDTTPTALGTRGEGAHLGWGAGRLQLQKLGLGRPAGGRQRRVPGGHSQQRPSTQPGLGGLFVYINF
FSFLLFFFFNFLSFSLEKGSVHAPGWHPPPPMPAQRRGMALRGEAPGVHLPRDREGGREGEALAGPTHPQGRHSTCTEGRGWPSPLSASP

--------------------------------------------------------------

>102043_102043_6_ZNF420-DPF1_ZNF420_chr19_37582023_ENST00000304239_DPF1_chr19_38704396_ENST00000456296_length(amino acids)=146AA_BP=
MRSGLPHVLPESPHGGAPGRELELSPLSPAPEGKGFCLHHPHLGRLGSPRLWGGARLPASPSSSILPHPEHPAGGGGEGEAERGLGHPLP

--------------------------------------------------------------

>102043_102043_7_ZNF420-DPF1_ZNF420_chr19_37582023_ENST00000337995_DPF1_chr19_38704396_ENST00000355526_length(amino acids)=163AA_BP=
MRSGLPHVLPESPHGGAPGRELELSPLSPAPEGKGFCLHHPHLGRLGSPRLWGGARLPASPSSSILPHPEHPAGGGGEGEAERGLGHPLP

--------------------------------------------------------------

>102043_102043_8_ZNF420-DPF1_ZNF420_chr19_37582023_ENST00000337995_DPF1_chr19_38704396_ENST00000412732_length(amino acids)=306AA_BP=
MQSQFPFFKTRTTNTHNHKKQPRPLTPPKWPARGAGAARPGGAGGGREKESVAESVLLIPAGAGRGPTRPHHRHPPATAGTGRAQAGAVG
EGQEQSSKPRFTSCSIHRGHQEGRVDTTPTALGTRGEGAHLGWGAGRLQLQKLGLGRPAGGRQRRVPGGHSQQRPSTQPGLGGLFVYINF
FSFLLFFFFNFLSFSLEKGSVHAPGWHPPPPMPAQRRGMALRGEAPGVHLPRDREGGREGEALAGPTHPQGRHSTCTEGRGWPSPLSASP

--------------------------------------------------------------

>102043_102043_9_ZNF420-DPF1_ZNF420_chr19_37582023_ENST00000337995_DPF1_chr19_38704396_ENST00000414789_length(amino acids)=163AA_BP=
MRSGLPHVLPESPHGGAPGRELELSPLSPAPEGKGFCLHHPHLGRLGSPRLWGGARLPASPSSSILPHPEHPAGGGGEGEAERGLGHPLP

--------------------------------------------------------------

>102043_102043_10_ZNF420-DPF1_ZNF420_chr19_37582023_ENST00000337995_DPF1_chr19_38704396_ENST00000416611_length(amino acids)=306AA_BP=
MQSQFPFFKTRTTNTHNHKKQPRPLTPPKWPARGAGAARPGGAGGGREKESVAESVLLIPAGAGRGPTRPHHRHPPATAGTGRAQAGAVG
EGQEQSSKPRFTSCSIHRGHQEGRVDTTPTALGTRGEGAHLGWGAGRLQLQKLGLGRPAGGRQRRVPGGHSQQRPSTQPGLGGLFVYINF
FSFLLFFFFNFLSFSLEKGSVHAPGWHPPPPMPAQRRGMALRGEAPGVHLPRDREGGREGEALAGPTHPQGRHSTCTEGRGWPSPLSASP

--------------------------------------------------------------

>102043_102043_11_ZNF420-DPF1_ZNF420_chr19_37582023_ENST00000337995_DPF1_chr19_38704396_ENST00000420980_length(amino acids)=306AA_BP=
MQSQFPFFKTRTTNTHNHKKQPRPLTPPKWPARGAGAARPGGAGGGREKESVAESVLLIPAGAGRGPTRPHHRHPPATAGTGRAQAGAVG
EGQEQSSKPRFTSCSIHRGHQEGRVDTTPTALGTRGEGAHLGWGAGRLQLQKLGLGRPAGGRQRRVPGGHSQQRPSTQPGLGGLFVYINF
FSFLLFFFFNFLSFSLEKGSVHAPGWHPPPPMPAQRRGMALRGEAPGVHLPRDREGGREGEALAGPTHPQGRHSTCTEGRGWPSPLSASP

--------------------------------------------------------------

>102043_102043_12_ZNF420-DPF1_ZNF420_chr19_37582023_ENST00000337995_DPF1_chr19_38704396_ENST00000456296_length(amino acids)=146AA_BP=
MRSGLPHVLPESPHGGAPGRELELSPLSPAPEGKGFCLHHPHLGRLGSPRLWGGARLPASPSSSILPHPEHPAGGGGEGEAERGLGHPLP

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:37582023/chr19:38704396)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	DPF1 Q92782
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.	FUNCTION: May have an important role in developing neurons by participating in regulation of cell survival, possibly as a neurospecific transcription factor. Belongs to the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

DPF1

chr19:37582023

chr19:38704396

ENST00000412732

254_311

244.33333333333334

333.0

Zinc finger

PHD-type 1

Tgene

DPF1

chr19:37582023

chr19:38704396

ENST00000412732

308_368

244.33333333333334

333.0

Zinc finger

PHD-type 2

Tgene

DPF1

chr19:37582023

chr19:38704396

ENST00000414789

254_311

244.33333333333334

333.0

Zinc finger

PHD-type 1

Tgene

DPF1

chr19:37582023

chr19:38704396

ENST00000414789

308_368

244.33333333333334

333.0

Zinc finger

PHD-type 2

Tgene

DPF1

chr19:37582023

chr19:38704396

ENST00000420980

308_368

282.3333333333333

381.0

Zinc finger

PHD-type 2

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ZNF420

chr19:37582023

chr19:38704396

ENST00000337995

6_86

45.333333333333336

689.0

Domain

KRAB

Hgene

ZNF420

chr19:37582023

chr19:38704396

ENST00000337995

139_161

45.333333333333336

689.0

Zinc finger

C2H2-type 1

Hgene

ZNF420

chr19:37582023

chr19:38704396

ENST00000337995

167_189

45.333333333333336

689.0

Zinc finger

C2H2-type 2

Hgene

ZNF420

chr19:37582023

chr19:38704396

ENST00000337995

195_217

45.333333333333336

689.0

Zinc finger

C2H2-type 3

Hgene

ZNF420

chr19:37582023

chr19:38704396

ENST00000337995

223_245

45.333333333333336

689.0

Zinc finger

C2H2-type 4

Hgene

ZNF420

chr19:37582023

chr19:38704396

ENST00000337995

251_273

45.333333333333336

689.0

Zinc finger

C2H2-type 5

Hgene

ZNF420

chr19:37582023

chr19:38704396

ENST00000337995

279_301

45.333333333333336

689.0

Zinc finger

C2H2-type 6

Hgene

ZNF420

chr19:37582023

chr19:38704396

ENST00000337995

307_329

45.333333333333336

689.0

Zinc finger

C2H2-type 7

Hgene

ZNF420

chr19:37582023

chr19:38704396

ENST00000337995

335_357

45.333333333333336

689.0

Zinc finger

C2H2-type 8

Hgene

ZNF420

chr19:37582023

chr19:38704396

ENST00000337995

363_385

45.333333333333336

689.0

Zinc finger

C2H2-type 9

Hgene

ZNF420

chr19:37582023

chr19:38704396

ENST00000337995

391_413

45.333333333333336

689.0

Zinc finger

C2H2-type 10

Hgene

ZNF420

chr19:37582023

chr19:38704396

ENST00000337995

419_441

45.333333333333336

689.0

Zinc finger

C2H2-type 11

Hgene

ZNF420

chr19:37582023

chr19:38704396

ENST00000337995

447_469

45.333333333333336

689.0

Zinc finger

C2H2-type 12

Hgene

ZNF420

chr19:37582023

chr19:38704396

ENST00000337995

475_497

45.333333333333336

689.0

Zinc finger

C2H2-type 13

Hgene

ZNF420

chr19:37582023

chr19:38704396

ENST00000337995

503_525

45.333333333333336

689.0

Zinc finger

C2H2-type 14

Hgene

ZNF420

chr19:37582023

chr19:38704396

ENST00000337995

531_553

45.333333333333336

689.0

Zinc finger

C2H2-type 15

Hgene

ZNF420

chr19:37582023

chr19:38704396

ENST00000337995

559_581

45.333333333333336

689.0

Zinc finger

C2H2-type 16

Hgene

ZNF420

chr19:37582023

chr19:38704396

ENST00000337995

587_609

45.333333333333336

689.0

Zinc finger

C2H2-type 17

Hgene

ZNF420

chr19:37582023

chr19:38704396

ENST00000337995

615_637

45.333333333333336

689.0

Zinc finger

C2H2-type 18

Hgene

ZNF420

chr19:37582023

chr19:38704396

ENST00000337995

643_665

45.333333333333336

689.0

Zinc finger

C2H2-type 19

Tgene

DPF1

chr19:37582023

chr19:38704396

ENST00000355526

254_311

326.3333333333333

415.0

Zinc finger

PHD-type 1

Tgene

DPF1

chr19:37582023

chr19:38704396

ENST00000355526

308_368

326.3333333333333

415.0

Zinc finger

PHD-type 2

Tgene

DPF1

chr19:37582023

chr19:38704396

ENST00000420980

254_311

282.3333333333333

381.0

Zinc finger

PHD-type 1

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Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	AA seq	Len(AA seq)
PDB file >>>556_ZNF420_37582023_DPF1_38704396_ranked_0.pdb	ZNF420	37582023	37582023	ENST00000456296	DPF1	chr19	38704396	-	MQSQFPFFKTRTTNTHNHKKQPRPLTPPKWPARGAGAARPGGAGGGREKESVAESVLLIPAGAGRGPTRPHHRHPPATAGTGRAQAGAVG EGQEQSSKPRFTSCSIHRGHQEGRVDTTPTALGTRGEGAHLGWGAGRLQLQKLGLGRPAGGRQRRVPGGHSQQRPSTQPGLGGLFVYINF FSFLLFFFFNFLSFSLEKGSVHAPGWHPPPPMPAQRRGMALRGEAPGVHLPRDREGGREGEALAGPTHPQGRHSTCTEGRGWPSPLSASP	306

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pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

ZNF420_pLDDT.png

DPF1_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

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Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
ZNF420
DPF1

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs to ZNF420-DPF1

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to ZNF420-DPF1

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source