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Center for Computational Systems Medicine level2
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:ZNF423-CCAR1

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: ZNF423-CCAR1
FusionPDB ID: 102051
FusionGDB2.0 ID: 102051
HgeneTgene
Gene symbol

ZNF423

CCAR1

Gene ID

23090

55749

Gene namezinc finger protein 423cell division cycle and apoptosis regulator 1
SynonymsEbfaz|JBTS19|NPHP14|OAZ|Roaz|ZFP423|Zfp104|hOAZ-
Cytomap

16q12.1

10q21.3

Type of geneprotein-codingprotein-coding
Descriptionzinc finger protein 423OLF-1/EBF associated zinc fingerSmad- and Olf-interacting zinc finger proteinearly B-cell factor associated zinc finger proteinolf1/EBF-associated zinc finger proteincell division cycle and apoptosis regulator protein 1cell cycle and apoptosis regulatory protein 1death inducer with SAP domain
Modification date2020032920200313
UniProtAcc.

Q8IX12

Ensembl transtripts involved in fusion geneENST idsENST00000262383, ENST00000561648, 
ENST00000562520, ENST00000562871, 
ENST00000563137, ENST00000535559, 
ENST00000567169, 		ENST00000483264, 
ENST00000265872, ENST00000535016, 
ENST00000543719, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score5 X 6 X 3=905 X 6 X 3=90
# samples 66
** MAII scorelog2(6/90*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/90*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: ZNF423 [Title/Abstract] AND CCAR1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)ZNF423(49764682)-CCAR1(70545893), # samples:3
Anticipated loss of major functional domain due to fusion event.ZNF423-CCAR1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ZNF423-CCAR1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ZNF423-CCAR1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ZNF423-CCAR1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ZNF423-CCAR1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
ZNF423-CCAR1 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.
ZNF423-CCAR1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
ZNF423-CCAR1 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneZNF423

GO:0045892

negative regulation of transcription, DNA-templated

10660046

HgeneZNF423

GO:0045893

positive regulation of transcription, DNA-templated

10660046

TgeneCCAR1

GO:0043065

positive regulation of apoptotic process

12816952


check buttonFusion gene breakpoints across ZNF423 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CCAR1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4UCSTCGA-N8-A4PQ-01AZNF423chr16

49764682

-CCAR1chr10

70545893

+
ChimerDB4UCSTCGA-N8-A4PQZNF423chr16

49764681

-CCAR1chr10

70545892

+
ChimerDB4UCSTCGA-N8-A4PQZNF423chr16

49764682

-CCAR1chr10

70545893

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000561648ZNF423chr1649764682-ENST00000535016CCAR1chr1070545893+1420331541133359
ENST00000561648ZNF423chr1649764682-ENST00000265872CCAR1chr1070545893+2245331541133359
ENST00000561648ZNF423chr1649764682-ENST00000543719CCAR1chr1070545893+1134331541133359
ENST00000561648ZNF423chr1649764681-ENST00000535016CCAR1chr1070545892+1420331541133359
ENST00000561648ZNF423chr1649764681-ENST00000265872CCAR1chr1070545892+2245331541133359
ENST00000561648ZNF423chr1649764681-ENST00000543719CCAR1chr1070545892+1134331541133359

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000561648ENST00000535016ZNF423chr1649764682-CCAR1chr1070545893+0.0004641760.9995358
ENST00000561648ENST00000265872ZNF423chr1649764682-CCAR1chr1070545893+0.0002627490.9997372
ENST00000561648ENST00000543719ZNF423chr1649764682-CCAR1chr1070545893+0.0013604150.9986395
ENST00000561648ENST00000535016ZNF423chr1649764681-CCAR1chr1070545892+0.0004641760.9995358
ENST00000561648ENST00000265872ZNF423chr1649764681-CCAR1chr1070545892+0.0002627490.9997372
ENST00000561648ENST00000543719ZNF423chr1649764681-CCAR1chr1070545892+0.0013604150.9986395

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>102051_102051_1_ZNF423-CCAR1_ZNF423_chr16_49764681_ENST00000561648_CCAR1_chr10_70545892_ENST00000265872_length(amino acids)=359AA_BP=92
MHKKRVEEGEASDFSLAWDSSVTAAGGLEGEPECDQKTSRALEDRNSVTSQEERNEDDEDMEDESIYTCDHCQQDFESLADLTDHRAHRC
PGDRDEEEMTKRDDKRDINRYCKERPSKDKEKEKTQMITINRDLLMAFVYFDQSHCGYLLEKDLEEILYTLGLHLSRAQVKKLLNKVVLR
ESCFYRKLTDTSKDEENHEESESLQEDMLGNRLLLPTPTVKQESKDVEENVGLIVYNGAMVDVGSLLQKLEKSEKVRAEVEQKLQLLEEK

--------------------------------------------------------------

>102051_102051_2_ZNF423-CCAR1_ZNF423_chr16_49764681_ENST00000561648_CCAR1_chr10_70545892_ENST00000535016_length(amino acids)=359AA_BP=92
MHKKRVEEGEASDFSLAWDSSVTAAGGLEGEPECDQKTSRALEDRNSVTSQEERNEDDEDMEDESIYTCDHCQQDFESLADLTDHRAHRC
PGDRDEEEMTKRDDKRDINRYCKERPSKDKEKEKTQMITINRDLLMAFVYFDQSHCGYLLEKDLEEILYTLGLHLSRAQVKKLLNKVVLR
ESCFYRKLTDTSKDEENHEESESLQEDMLGNRLLLPTPTVKQESKDVEENVGLIVYNGAMVDVGSLLQKLEKSEKVRAEVEQKLQLLEEK

--------------------------------------------------------------

>102051_102051_3_ZNF423-CCAR1_ZNF423_chr16_49764681_ENST00000561648_CCAR1_chr10_70545892_ENST00000543719_length(amino acids)=359AA_BP=92
MHKKRVEEGEASDFSLAWDSSVTAAGGLEGEPECDQKTSRALEDRNSVTSQEERNEDDEDMEDESIYTCDHCQQDFESLADLTDHRAHRC
PGDRDEEEMTKRDDKRDINRYCKERPSKDKEKEKTQMITINRDLLMAFVYFDQSHCGYLLEKDLEEILYTLGLHLSRAQVKKLLNKVVLR
ESCFYRKLTDTSKDEENHEESESLQEDMLGNRLLLPTPTVKQESKDVEENVGLIVYNGAMVDVGSLLQKLEKSEKVRAEVEQKLQLLEEK

--------------------------------------------------------------

>102051_102051_4_ZNF423-CCAR1_ZNF423_chr16_49764682_ENST00000561648_CCAR1_chr10_70545893_ENST00000265872_length(amino acids)=359AA_BP=92
MHKKRVEEGEASDFSLAWDSSVTAAGGLEGEPECDQKTSRALEDRNSVTSQEERNEDDEDMEDESIYTCDHCQQDFESLADLTDHRAHRC
PGDRDEEEMTKRDDKRDINRYCKERPSKDKEKEKTQMITINRDLLMAFVYFDQSHCGYLLEKDLEEILYTLGLHLSRAQVKKLLNKVVLR
ESCFYRKLTDTSKDEENHEESESLQEDMLGNRLLLPTPTVKQESKDVEENVGLIVYNGAMVDVGSLLQKLEKSEKVRAEVEQKLQLLEEK

--------------------------------------------------------------

>102051_102051_5_ZNF423-CCAR1_ZNF423_chr16_49764682_ENST00000561648_CCAR1_chr10_70545893_ENST00000535016_length(amino acids)=359AA_BP=92
MHKKRVEEGEASDFSLAWDSSVTAAGGLEGEPECDQKTSRALEDRNSVTSQEERNEDDEDMEDESIYTCDHCQQDFESLADLTDHRAHRC
PGDRDEEEMTKRDDKRDINRYCKERPSKDKEKEKTQMITINRDLLMAFVYFDQSHCGYLLEKDLEEILYTLGLHLSRAQVKKLLNKVVLR
ESCFYRKLTDTSKDEENHEESESLQEDMLGNRLLLPTPTVKQESKDVEENVGLIVYNGAMVDVGSLLQKLEKSEKVRAEVEQKLQLLEEK

--------------------------------------------------------------

>102051_102051_6_ZNF423-CCAR1_ZNF423_chr16_49764682_ENST00000561648_CCAR1_chr10_70545893_ENST00000543719_length(amino acids)=359AA_BP=92
MHKKRVEEGEASDFSLAWDSSVTAAGGLEGEPECDQKTSRALEDRNSVTSQEERNEDDEDMEDESIYTCDHCQQDFESLADLTDHRAHRC
PGDRDEEEMTKRDDKRDINRYCKERPSKDKEKEKTQMITINRDLLMAFVYFDQSHCGYLLEKDLEEILYTLGLHLSRAQVKKLLNKVVLR
ESCFYRKLTDTSKDEENHEESESLQEDMLGNRLLLPTPTVKQESKDVEENVGLIVYNGAMVDVGSLLQKLEKSEKVRAEVEQKLQLLEEK

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr16:49764682/chr10:70545893)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.CCAR1

Q8IX12

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Associates with components of the Mediator and p160 coactivator complexes that play a role as intermediaries transducing regulatory signals from upstream transcriptional activator proteins to basal transcription machinery at the core promoter. Recruited to endogenous nuclear receptor target genes in response to the appropriate hormone. Also functions as a p53 coactivator. May thus play an important role in transcriptional regulation (By similarity). May be involved in apoptosis signaling in the presence of the reinoid CD437. Apoptosis induction involves sequestration of 14-3-3 protein(s) and mediated altered expression of multiple cell cycle regulatory genes including MYC, CCNB1 and CDKN1A. Plays a role in cell cycle progression and/or cell proliferation (PubMed:12816952). In association with CALCOCO1 enhances GATA1- and MED1-mediated transcriptional activation from the gamma-globin promoter during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781). Can act as a both a coactivator and corepressor of AR-mediated transcription. Contributes to chromatin looping and AR transcription complex assembly by stabilizing AR-GATA2 association on chromatin and facilitating MED1 and RNA polymerase II recruitment to AR-binding sites. May play an important role in the growth and tumorigenesis of prostate cancer cells (PubMed:23887938). {ECO:0000250|UniProtKB:Q8CH18, ECO:0000269|PubMed:12816952, ECO:0000269|PubMed:23887938, ECO:0000269|PubMed:24245781}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneZNF423chr16:49764681chr10:70545892ENST00000262383-4967_9392.333333333333331285.0Zinc fingerC2H2-type 1%3B degenerate
HgeneZNF423chr16:49764681chr10:70545892ENST00000561648-3867_9392.333333333333331285.0Zinc fingerC2H2-type 1%3B degenerate
HgeneZNF423chr16:49764682chr10:70545893ENST00000262383-4967_9392.333333333333331285.0Zinc fingerC2H2-type 1%3B degenerate
HgeneZNF423chr16:49764682chr10:70545893ENST00000561648-3867_9392.333333333333331285.0Zinc fingerC2H2-type 1%3B degenerate
TgeneCCAR1chr16:49764681chr10:70545892ENST0000026587218251033_1114883.33333333333341151.0Coiled coilOntology_term=ECO:0000255
TgeneCCAR1chr16:49764681chr10:70545892ENST0000053501617241033_1114868.33333333333341136.0Coiled coilOntology_term=ECO:0000255
TgeneCCAR1chr16:49764681chr10:70545892ENST0000054371917241033_1114868.33333333333341136.0Coiled coilOntology_term=ECO:0000255
TgeneCCAR1chr16:49764682chr10:70545893ENST0000026587218251033_1114883.33333333333341151.0Coiled coilOntology_term=ECO:0000255
TgeneCCAR1chr16:49764682chr10:70545893ENST0000053501617241033_1114868.33333333333341136.0Coiled coilOntology_term=ECO:0000255
TgeneCCAR1chr16:49764682chr10:70545893ENST0000054371917241033_1114868.33333333333341136.0Coiled coilOntology_term=ECO:0000255

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneZNF423chr16:49764681chr10:70545892ENST00000262383-491020_104292.333333333333331285.0Zinc fingerC2H2-type 24
HgeneZNF423chr16:49764681chr10:70545892ENST00000262383-491064_108292.333333333333331285.0Zinc fingerC2H2-type 25%3B degenerate
HgeneZNF423chr16:49764681chr10:70545892ENST00000262383-491120_114392.333333333333331285.0Zinc fingerC2H2-type 26
HgeneZNF423chr16:49764681chr10:70545892ENST00000262383-491168_119092.333333333333331285.0Zinc fingerC2H2-type 27
HgeneZNF423chr16:49764681chr10:70545892ENST00000262383-491198_122092.333333333333331285.0Zinc fingerC2H2-type 28
HgeneZNF423chr16:49764681chr10:70545892ENST00000262383-491229_125292.333333333333331285.0Zinc fingerC2H2-type 29
HgeneZNF423chr16:49764681chr10:70545892ENST00000262383-491259_128292.333333333333331285.0Zinc fingerC2H2-type 30
HgeneZNF423chr16:49764681chr10:70545892ENST00000262383-49138_16092.333333333333331285.0Zinc fingerC2H2-type 2
HgeneZNF423chr16:49764681chr10:70545892ENST00000262383-49166_18892.333333333333331285.0Zinc fingerC2H2-type 3
HgeneZNF423chr16:49764681chr10:70545892ENST00000262383-49194_21692.333333333333331285.0Zinc fingerC2H2-type 4
HgeneZNF423chr16:49764681chr10:70545892ENST00000262383-49222_24492.333333333333331285.0Zinc fingerC2H2-type 5
HgeneZNF423chr16:49764681chr10:70545892ENST00000262383-49263_28692.333333333333331285.0Zinc fingerC2H2-type 6
HgeneZNF423chr16:49764681chr10:70545892ENST00000262383-49295_31892.333333333333331285.0Zinc fingerC2H2-type 7
HgeneZNF423chr16:49764681chr10:70545892ENST00000262383-49323_34592.333333333333331285.0Zinc fingerC2H2-type 8
HgeneZNF423chr16:49764681chr10:70545892ENST00000262383-49409_43392.333333333333331285.0Zinc fingerC2H2-type 9%3B degenerate
HgeneZNF423chr16:49764681chr10:70545892ENST00000262383-49441_46492.333333333333331285.0Zinc fingerC2H2-type 10
HgeneZNF423chr16:49764681chr10:70545892ENST00000262383-49480_50392.333333333333331285.0Zinc fingerC2H2-type 11
HgeneZNF423chr16:49764681chr10:70545892ENST00000262383-49517_54092.333333333333331285.0Zinc fingerC2H2-type 12
HgeneZNF423chr16:49764681chr10:70545892ENST00000262383-49563_58892.333333333333331285.0Zinc fingerC2H2-type 13%3B atypical
HgeneZNF423chr16:49764681chr10:70545892ENST00000262383-49632_65492.333333333333331285.0Zinc fingerC2H2-type 14
HgeneZNF423chr16:49764681chr10:70545892ENST00000262383-49662_68492.333333333333331285.0Zinc fingerC2H2-type 15
HgeneZNF423chr16:49764681chr10:70545892ENST00000262383-49692_71592.333333333333331285.0Zinc fingerC2H2-type 16
HgeneZNF423chr16:49764681chr10:70545892ENST00000262383-49720_74392.333333333333331285.0Zinc fingerC2H2-type 17
HgeneZNF423chr16:49764681chr10:70545892ENST00000262383-49750_77392.333333333333331285.0Zinc fingerC2H2-type 18
HgeneZNF423chr16:49764681chr10:70545892ENST00000262383-49781_80392.333333333333331285.0Zinc fingerC2H2-type 19
HgeneZNF423chr16:49764681chr10:70545892ENST00000262383-49807_83092.333333333333331285.0Zinc fingerC2H2-type 20
HgeneZNF423chr16:49764681chr10:70545892ENST00000262383-49886_90892.333333333333331285.0Zinc fingerC2H2-type 21%3B degenerate
HgeneZNF423chr16:49764681chr10:70545892ENST00000262383-49930_95292.333333333333331285.0Zinc fingerC2H2-type 22
HgeneZNF423chr16:49764681chr10:70545892ENST00000262383-49959_98192.333333333333331285.0Zinc fingerC2H2-type 23
HgeneZNF423chr16:49764681chr10:70545892ENST00000561648-381020_104292.333333333333331285.0Zinc fingerC2H2-type 24
HgeneZNF423chr16:49764681chr10:70545892ENST00000561648-381064_108292.333333333333331285.0Zinc fingerC2H2-type 25%3B degenerate
HgeneZNF423chr16:49764681chr10:70545892ENST00000561648-381120_114392.333333333333331285.0Zinc fingerC2H2-type 26
HgeneZNF423chr16:49764681chr10:70545892ENST00000561648-381168_119092.333333333333331285.0Zinc fingerC2H2-type 27
HgeneZNF423chr16:49764681chr10:70545892ENST00000561648-381198_122092.333333333333331285.0Zinc fingerC2H2-type 28
HgeneZNF423chr16:49764681chr10:70545892ENST00000561648-381229_125292.333333333333331285.0Zinc fingerC2H2-type 29
HgeneZNF423chr16:49764681chr10:70545892ENST00000561648-381259_128292.333333333333331285.0Zinc fingerC2H2-type 30
HgeneZNF423chr16:49764681chr10:70545892ENST00000561648-38138_16092.333333333333331285.0Zinc fingerC2H2-type 2
HgeneZNF423chr16:49764681chr10:70545892ENST00000561648-38166_18892.333333333333331285.0Zinc fingerC2H2-type 3
HgeneZNF423chr16:49764681chr10:70545892ENST00000561648-38194_21692.333333333333331285.0Zinc fingerC2H2-type 4
HgeneZNF423chr16:49764681chr10:70545892ENST00000561648-38222_24492.333333333333331285.0Zinc fingerC2H2-type 5
HgeneZNF423chr16:49764681chr10:70545892ENST00000561648-38263_28692.333333333333331285.0Zinc fingerC2H2-type 6
HgeneZNF423chr16:49764681chr10:70545892ENST00000561648-38295_31892.333333333333331285.0Zinc fingerC2H2-type 7
HgeneZNF423chr16:49764681chr10:70545892ENST00000561648-38323_34592.333333333333331285.0Zinc fingerC2H2-type 8
HgeneZNF423chr16:49764681chr10:70545892ENST00000561648-38409_43392.333333333333331285.0Zinc fingerC2H2-type 9%3B degenerate
HgeneZNF423chr16:49764681chr10:70545892ENST00000561648-38441_46492.333333333333331285.0Zinc fingerC2H2-type 10
HgeneZNF423chr16:49764681chr10:70545892ENST00000561648-38480_50392.333333333333331285.0Zinc fingerC2H2-type 11
HgeneZNF423chr16:49764681chr10:70545892ENST00000561648-38517_54092.333333333333331285.0Zinc fingerC2H2-type 12
HgeneZNF423chr16:49764681chr10:70545892ENST00000561648-38563_58892.333333333333331285.0Zinc fingerC2H2-type 13%3B atypical
HgeneZNF423chr16:49764681chr10:70545892ENST00000561648-38632_65492.333333333333331285.0Zinc fingerC2H2-type 14
HgeneZNF423chr16:49764681chr10:70545892ENST00000561648-38662_68492.333333333333331285.0Zinc fingerC2H2-type 15
HgeneZNF423chr16:49764681chr10:70545892ENST00000561648-38692_71592.333333333333331285.0Zinc fingerC2H2-type 16
HgeneZNF423chr16:49764681chr10:70545892ENST00000561648-38720_74392.333333333333331285.0Zinc fingerC2H2-type 17
HgeneZNF423chr16:49764681chr10:70545892ENST00000561648-38750_77392.333333333333331285.0Zinc fingerC2H2-type 18
HgeneZNF423chr16:49764681chr10:70545892ENST00000561648-38781_80392.333333333333331285.0Zinc fingerC2H2-type 19
HgeneZNF423chr16:49764681chr10:70545892ENST00000561648-38807_83092.333333333333331285.0Zinc fingerC2H2-type 20
HgeneZNF423chr16:49764681chr10:70545892ENST00000561648-38886_90892.333333333333331285.0Zinc fingerC2H2-type 21%3B degenerate
HgeneZNF423chr16:49764681chr10:70545892ENST00000561648-38930_95292.333333333333331285.0Zinc fingerC2H2-type 22
HgeneZNF423chr16:49764681chr10:70545892ENST00000561648-38959_98192.333333333333331285.0Zinc fingerC2H2-type 23
HgeneZNF423chr16:49764681chr10:70545892ENST00000562520-381020_104232.3333333333333361225.0Zinc fingerC2H2-type 24
HgeneZNF423chr16:49764681chr10:70545892ENST00000562520-381064_108232.3333333333333361225.0Zinc fingerC2H2-type 25%3B degenerate
HgeneZNF423chr16:49764681chr10:70545892ENST00000562520-381120_114332.3333333333333361225.0Zinc fingerC2H2-type 26
HgeneZNF423chr16:49764681chr10:70545892ENST00000562520-381168_119032.3333333333333361225.0Zinc fingerC2H2-type 27
HgeneZNF423chr16:49764681chr10:70545892ENST00000562520-381198_122032.3333333333333361225.0Zinc fingerC2H2-type 28
HgeneZNF423chr16:49764681chr10:70545892ENST00000562520-381229_125232.3333333333333361225.0Zinc fingerC2H2-type 29
HgeneZNF423chr16:49764681chr10:70545892ENST00000562520-381259_128232.3333333333333361225.0Zinc fingerC2H2-type 30
HgeneZNF423chr16:49764681chr10:70545892ENST00000562520-38138_16032.3333333333333361225.0Zinc fingerC2H2-type 2
HgeneZNF423chr16:49764681chr10:70545892ENST00000562520-38166_18832.3333333333333361225.0Zinc fingerC2H2-type 3
HgeneZNF423chr16:49764681chr10:70545892ENST00000562520-38194_21632.3333333333333361225.0Zinc fingerC2H2-type 4
HgeneZNF423chr16:49764681chr10:70545892ENST00000562520-38222_24432.3333333333333361225.0Zinc fingerC2H2-type 5
HgeneZNF423chr16:49764681chr10:70545892ENST00000562520-38263_28632.3333333333333361225.0Zinc fingerC2H2-type 6
HgeneZNF423chr16:49764681chr10:70545892ENST00000562520-38295_31832.3333333333333361225.0Zinc fingerC2H2-type 7
HgeneZNF423chr16:49764681chr10:70545892ENST00000562520-38323_34532.3333333333333361225.0Zinc fingerC2H2-type 8
HgeneZNF423chr16:49764681chr10:70545892ENST00000562520-38409_43332.3333333333333361225.0Zinc fingerC2H2-type 9%3B degenerate
HgeneZNF423chr16:49764681chr10:70545892ENST00000562520-38441_46432.3333333333333361225.0Zinc fingerC2H2-type 10
HgeneZNF423chr16:49764681chr10:70545892ENST00000562520-38480_50332.3333333333333361225.0Zinc fingerC2H2-type 11
HgeneZNF423chr16:49764681chr10:70545892ENST00000562520-38517_54032.3333333333333361225.0Zinc fingerC2H2-type 12
HgeneZNF423chr16:49764681chr10:70545892ENST00000562520-38563_58832.3333333333333361225.0Zinc fingerC2H2-type 13%3B atypical
HgeneZNF423chr16:49764681chr10:70545892ENST00000562520-38632_65432.3333333333333361225.0Zinc fingerC2H2-type 14
HgeneZNF423chr16:49764681chr10:70545892ENST00000562520-38662_68432.3333333333333361225.0Zinc fingerC2H2-type 15
HgeneZNF423chr16:49764681chr10:70545892ENST00000562520-3867_9332.3333333333333361225.0Zinc fingerC2H2-type 1%3B degenerate
HgeneZNF423chr16:49764681chr10:70545892ENST00000562520-38692_71532.3333333333333361225.0Zinc fingerC2H2-type 16
HgeneZNF423chr16:49764681chr10:70545892ENST00000562520-38720_74332.3333333333333361225.0Zinc fingerC2H2-type 17
HgeneZNF423chr16:49764681chr10:70545892ENST00000562520-38750_77332.3333333333333361225.0Zinc fingerC2H2-type 18
HgeneZNF423chr16:49764681chr10:70545892ENST00000562520-38781_80332.3333333333333361225.0Zinc fingerC2H2-type 19
HgeneZNF423chr16:49764681chr10:70545892ENST00000562520-38807_83032.3333333333333361225.0Zinc fingerC2H2-type 20
HgeneZNF423chr16:49764681chr10:70545892ENST00000562520-38886_90832.3333333333333361225.0Zinc fingerC2H2-type 21%3B degenerate
HgeneZNF423chr16:49764681chr10:70545892ENST00000562520-38930_95232.3333333333333361225.0Zinc fingerC2H2-type 22
HgeneZNF423chr16:49764681chr10:70545892ENST00000562520-38959_98132.3333333333333361225.0Zinc fingerC2H2-type 23
HgeneZNF423chr16:49764681chr10:70545892ENST00000562871-271020_104232.3333333333333361225.0Zinc fingerC2H2-type 24
HgeneZNF423chr16:49764681chr10:70545892ENST00000562871-271064_108232.3333333333333361225.0Zinc fingerC2H2-type 25%3B degenerate
HgeneZNF423chr16:49764681chr10:70545892ENST00000562871-271120_114332.3333333333333361225.0Zinc fingerC2H2-type 26
HgeneZNF423chr16:49764681chr10:70545892ENST00000562871-271168_119032.3333333333333361225.0Zinc fingerC2H2-type 27
HgeneZNF423chr16:49764681chr10:70545892ENST00000562871-271198_122032.3333333333333361225.0Zinc fingerC2H2-type 28
HgeneZNF423chr16:49764681chr10:70545892ENST00000562871-271229_125232.3333333333333361225.0Zinc fingerC2H2-type 29
HgeneZNF423chr16:49764681chr10:70545892ENST00000562871-271259_128232.3333333333333361225.0Zinc fingerC2H2-type 30
HgeneZNF423chr16:49764681chr10:70545892ENST00000562871-27138_16032.3333333333333361225.0Zinc fingerC2H2-type 2
HgeneZNF423chr16:49764681chr10:70545892ENST00000562871-27166_18832.3333333333333361225.0Zinc fingerC2H2-type 3
HgeneZNF423chr16:49764681chr10:70545892ENST00000562871-27194_21632.3333333333333361225.0Zinc fingerC2H2-type 4
HgeneZNF423chr16:49764681chr10:70545892ENST00000562871-27222_24432.3333333333333361225.0Zinc fingerC2H2-type 5
HgeneZNF423chr16:49764681chr10:70545892ENST00000562871-27263_28632.3333333333333361225.0Zinc fingerC2H2-type 6
HgeneZNF423chr16:49764681chr10:70545892ENST00000562871-27295_31832.3333333333333361225.0Zinc fingerC2H2-type 7
HgeneZNF423chr16:49764681chr10:70545892ENST00000562871-27323_34532.3333333333333361225.0Zinc fingerC2H2-type 8
HgeneZNF423chr16:49764681chr10:70545892ENST00000562871-27409_43332.3333333333333361225.0Zinc fingerC2H2-type 9%3B degenerate
HgeneZNF423chr16:49764681chr10:70545892ENST00000562871-27441_46432.3333333333333361225.0Zinc fingerC2H2-type 10
HgeneZNF423chr16:49764681chr10:70545892ENST00000562871-27480_50332.3333333333333361225.0Zinc fingerC2H2-type 11
HgeneZNF423chr16:49764681chr10:70545892ENST00000562871-27517_54032.3333333333333361225.0Zinc fingerC2H2-type 12
HgeneZNF423chr16:49764681chr10:70545892ENST00000562871-27563_58832.3333333333333361225.0Zinc fingerC2H2-type 13%3B atypical
HgeneZNF423chr16:49764681chr10:70545892ENST00000562871-27632_65432.3333333333333361225.0Zinc fingerC2H2-type 14
HgeneZNF423chr16:49764681chr10:70545892ENST00000562871-27662_68432.3333333333333361225.0Zinc fingerC2H2-type 15
HgeneZNF423chr16:49764681chr10:70545892ENST00000562871-2767_9332.3333333333333361225.0Zinc fingerC2H2-type 1%3B degenerate
HgeneZNF423chr16:49764681chr10:70545892ENST00000562871-27692_71532.3333333333333361225.0Zinc fingerC2H2-type 16
HgeneZNF423chr16:49764681chr10:70545892ENST00000562871-27720_74332.3333333333333361225.0Zinc fingerC2H2-type 17
HgeneZNF423chr16:49764681chr10:70545892ENST00000562871-27750_77332.3333333333333361225.0Zinc fingerC2H2-type 18
HgeneZNF423chr16:49764681chr10:70545892ENST00000562871-27781_80332.3333333333333361225.0Zinc fingerC2H2-type 19
HgeneZNF423chr16:49764681chr10:70545892ENST00000562871-27807_83032.3333333333333361225.0Zinc fingerC2H2-type 20
HgeneZNF423chr16:49764681chr10:70545892ENST00000562871-27886_90832.3333333333333361225.0Zinc fingerC2H2-type 21%3B degenerate
HgeneZNF423chr16:49764681chr10:70545892ENST00000562871-27930_95232.3333333333333361225.0Zinc fingerC2H2-type 22
HgeneZNF423chr16:49764681chr10:70545892ENST00000562871-27959_98132.3333333333333361225.0Zinc fingerC2H2-type 23
HgeneZNF423chr16:49764681chr10:70545892ENST00000563137-381020_104232.3333333333333361225.0Zinc fingerC2H2-type 24
HgeneZNF423chr16:49764681chr10:70545892ENST00000563137-381064_108232.3333333333333361225.0Zinc fingerC2H2-type 25%3B degenerate
HgeneZNF423chr16:49764681chr10:70545892ENST00000563137-381120_114332.3333333333333361225.0Zinc fingerC2H2-type 26
HgeneZNF423chr16:49764681chr10:70545892ENST00000563137-381168_119032.3333333333333361225.0Zinc fingerC2H2-type 27
HgeneZNF423chr16:49764681chr10:70545892ENST00000563137-381198_122032.3333333333333361225.0Zinc fingerC2H2-type 28
HgeneZNF423chr16:49764681chr10:70545892ENST00000563137-381229_125232.3333333333333361225.0Zinc fingerC2H2-type 29
HgeneZNF423chr16:49764681chr10:70545892ENST00000563137-381259_128232.3333333333333361225.0Zinc fingerC2H2-type 30
HgeneZNF423chr16:49764681chr10:70545892ENST00000563137-38138_16032.3333333333333361225.0Zinc fingerC2H2-type 2
HgeneZNF423chr16:49764681chr10:70545892ENST00000563137-38166_18832.3333333333333361225.0Zinc fingerC2H2-type 3
HgeneZNF423chr16:49764681chr10:70545892ENST00000563137-38194_21632.3333333333333361225.0Zinc fingerC2H2-type 4
HgeneZNF423chr16:49764681chr10:70545892ENST00000563137-38222_24432.3333333333333361225.0Zinc fingerC2H2-type 5
HgeneZNF423chr16:49764681chr10:70545892ENST00000563137-38263_28632.3333333333333361225.0Zinc fingerC2H2-type 6
HgeneZNF423chr16:49764681chr10:70545892ENST00000563137-38295_31832.3333333333333361225.0Zinc fingerC2H2-type 7
HgeneZNF423chr16:49764681chr10:70545892ENST00000563137-38323_34532.3333333333333361225.0Zinc fingerC2H2-type 8
HgeneZNF423chr16:49764681chr10:70545892ENST00000563137-38409_43332.3333333333333361225.0Zinc fingerC2H2-type 9%3B degenerate
HgeneZNF423chr16:49764681chr10:70545892ENST00000563137-38441_46432.3333333333333361225.0Zinc fingerC2H2-type 10
HgeneZNF423chr16:49764681chr10:70545892ENST00000563137-38480_50332.3333333333333361225.0Zinc fingerC2H2-type 11
HgeneZNF423chr16:49764681chr10:70545892ENST00000563137-38517_54032.3333333333333361225.0Zinc fingerC2H2-type 12
HgeneZNF423chr16:49764681chr10:70545892ENST00000563137-38563_58832.3333333333333361225.0Zinc fingerC2H2-type 13%3B atypical
HgeneZNF423chr16:49764681chr10:70545892ENST00000563137-38632_65432.3333333333333361225.0Zinc fingerC2H2-type 14
HgeneZNF423chr16:49764681chr10:70545892ENST00000563137-38662_68432.3333333333333361225.0Zinc fingerC2H2-type 15
HgeneZNF423chr16:49764681chr10:70545892ENST00000563137-3867_9332.3333333333333361225.0Zinc fingerC2H2-type 1%3B degenerate
HgeneZNF423chr16:49764681chr10:70545892ENST00000563137-38692_71532.3333333333333361225.0Zinc fingerC2H2-type 16
HgeneZNF423chr16:49764681chr10:70545892ENST00000563137-38720_74332.3333333333333361225.0Zinc fingerC2H2-type 17
HgeneZNF423chr16:49764681chr10:70545892ENST00000563137-38750_77332.3333333333333361225.0Zinc fingerC2H2-type 18
HgeneZNF423chr16:49764681chr10:70545892ENST00000563137-38781_80332.3333333333333361225.0Zinc fingerC2H2-type 19
HgeneZNF423chr16:49764681chr10:70545892ENST00000563137-38807_83032.3333333333333361225.0Zinc fingerC2H2-type 20
HgeneZNF423chr16:49764681chr10:70545892ENST00000563137-38886_90832.3333333333333361225.0Zinc fingerC2H2-type 21%3B degenerate
HgeneZNF423chr16:49764681chr10:70545892ENST00000563137-38930_95232.3333333333333361225.0Zinc fingerC2H2-type 22
HgeneZNF423chr16:49764681chr10:70545892ENST00000563137-38959_98132.3333333333333361225.0Zinc fingerC2H2-type 23
HgeneZNF423chr16:49764682chr10:70545893ENST00000262383-491020_104292.333333333333331285.0Zinc fingerC2H2-type 24
HgeneZNF423chr16:49764682chr10:70545893ENST00000262383-491064_108292.333333333333331285.0Zinc fingerC2H2-type 25%3B degenerate
HgeneZNF423chr16:49764682chr10:70545893ENST00000262383-491120_114392.333333333333331285.0Zinc fingerC2H2-type 26
HgeneZNF423chr16:49764682chr10:70545893ENST00000262383-491168_119092.333333333333331285.0Zinc fingerC2H2-type 27
HgeneZNF423chr16:49764682chr10:70545893ENST00000262383-491198_122092.333333333333331285.0Zinc fingerC2H2-type 28
HgeneZNF423chr16:49764682chr10:70545893ENST00000262383-491229_125292.333333333333331285.0Zinc fingerC2H2-type 29
HgeneZNF423chr16:49764682chr10:70545893ENST00000262383-491259_128292.333333333333331285.0Zinc fingerC2H2-type 30
HgeneZNF423chr16:49764682chr10:70545893ENST00000262383-49138_16092.333333333333331285.0Zinc fingerC2H2-type 2
HgeneZNF423chr16:49764682chr10:70545893ENST00000262383-49166_18892.333333333333331285.0Zinc fingerC2H2-type 3
HgeneZNF423chr16:49764682chr10:70545893ENST00000262383-49194_21692.333333333333331285.0Zinc fingerC2H2-type 4
HgeneZNF423chr16:49764682chr10:70545893ENST00000262383-49222_24492.333333333333331285.0Zinc fingerC2H2-type 5
HgeneZNF423chr16:49764682chr10:70545893ENST00000262383-49263_28692.333333333333331285.0Zinc fingerC2H2-type 6
HgeneZNF423chr16:49764682chr10:70545893ENST00000262383-49295_31892.333333333333331285.0Zinc fingerC2H2-type 7
HgeneZNF423chr16:49764682chr10:70545893ENST00000262383-49323_34592.333333333333331285.0Zinc fingerC2H2-type 8
HgeneZNF423chr16:49764682chr10:70545893ENST00000262383-49409_43392.333333333333331285.0Zinc fingerC2H2-type 9%3B degenerate
HgeneZNF423chr16:49764682chr10:70545893ENST00000262383-49441_46492.333333333333331285.0Zinc fingerC2H2-type 10
HgeneZNF423chr16:49764682chr10:70545893ENST00000262383-49480_50392.333333333333331285.0Zinc fingerC2H2-type 11
HgeneZNF423chr16:49764682chr10:70545893ENST00000262383-49517_54092.333333333333331285.0Zinc fingerC2H2-type 12
HgeneZNF423chr16:49764682chr10:70545893ENST00000262383-49563_58892.333333333333331285.0Zinc fingerC2H2-type 13%3B atypical
HgeneZNF423chr16:49764682chr10:70545893ENST00000262383-49632_65492.333333333333331285.0Zinc fingerC2H2-type 14
HgeneZNF423chr16:49764682chr10:70545893ENST00000262383-49662_68492.333333333333331285.0Zinc fingerC2H2-type 15
HgeneZNF423chr16:49764682chr10:70545893ENST00000262383-49692_71592.333333333333331285.0Zinc fingerC2H2-type 16
HgeneZNF423chr16:49764682chr10:70545893ENST00000262383-49720_74392.333333333333331285.0Zinc fingerC2H2-type 17
HgeneZNF423chr16:49764682chr10:70545893ENST00000262383-49750_77392.333333333333331285.0Zinc fingerC2H2-type 18
HgeneZNF423chr16:49764682chr10:70545893ENST00000262383-49781_80392.333333333333331285.0Zinc fingerC2H2-type 19
HgeneZNF423chr16:49764682chr10:70545893ENST00000262383-49807_83092.333333333333331285.0Zinc fingerC2H2-type 20
HgeneZNF423chr16:49764682chr10:70545893ENST00000262383-49886_90892.333333333333331285.0Zinc fingerC2H2-type 21%3B degenerate
HgeneZNF423chr16:49764682chr10:70545893ENST00000262383-49930_95292.333333333333331285.0Zinc fingerC2H2-type 22
HgeneZNF423chr16:49764682chr10:70545893ENST00000262383-49959_98192.333333333333331285.0Zinc fingerC2H2-type 23
HgeneZNF423chr16:49764682chr10:70545893ENST00000561648-381020_104292.333333333333331285.0Zinc fingerC2H2-type 24
HgeneZNF423chr16:49764682chr10:70545893ENST00000561648-381064_108292.333333333333331285.0Zinc fingerC2H2-type 25%3B degenerate
HgeneZNF423chr16:49764682chr10:70545893ENST00000561648-381120_114392.333333333333331285.0Zinc fingerC2H2-type 26
HgeneZNF423chr16:49764682chr10:70545893ENST00000561648-381168_119092.333333333333331285.0Zinc fingerC2H2-type 27
HgeneZNF423chr16:49764682chr10:70545893ENST00000561648-381198_122092.333333333333331285.0Zinc fingerC2H2-type 28
HgeneZNF423chr16:49764682chr10:70545893ENST00000561648-381229_125292.333333333333331285.0Zinc fingerC2H2-type 29
HgeneZNF423chr16:49764682chr10:70545893ENST00000561648-381259_128292.333333333333331285.0Zinc fingerC2H2-type 30
HgeneZNF423chr16:49764682chr10:70545893ENST00000561648-38138_16092.333333333333331285.0Zinc fingerC2H2-type 2
HgeneZNF423chr16:49764682chr10:70545893ENST00000561648-38166_18892.333333333333331285.0Zinc fingerC2H2-type 3
HgeneZNF423chr16:49764682chr10:70545893ENST00000561648-38194_21692.333333333333331285.0Zinc fingerC2H2-type 4
HgeneZNF423chr16:49764682chr10:70545893ENST00000561648-38222_24492.333333333333331285.0Zinc fingerC2H2-type 5
HgeneZNF423chr16:49764682chr10:70545893ENST00000561648-38263_28692.333333333333331285.0Zinc fingerC2H2-type 6
HgeneZNF423chr16:49764682chr10:70545893ENST00000561648-38295_31892.333333333333331285.0Zinc fingerC2H2-type 7
HgeneZNF423chr16:49764682chr10:70545893ENST00000561648-38323_34592.333333333333331285.0Zinc fingerC2H2-type 8
HgeneZNF423chr16:49764682chr10:70545893ENST00000561648-38409_43392.333333333333331285.0Zinc fingerC2H2-type 9%3B degenerate
HgeneZNF423chr16:49764682chr10:70545893ENST00000561648-38441_46492.333333333333331285.0Zinc fingerC2H2-type 10
HgeneZNF423chr16:49764682chr10:70545893ENST00000561648-38480_50392.333333333333331285.0Zinc fingerC2H2-type 11
HgeneZNF423chr16:49764682chr10:70545893ENST00000561648-38517_54092.333333333333331285.0Zinc fingerC2H2-type 12
HgeneZNF423chr16:49764682chr10:70545893ENST00000561648-38563_58892.333333333333331285.0Zinc fingerC2H2-type 13%3B atypical
HgeneZNF423chr16:49764682chr10:70545893ENST00000561648-38632_65492.333333333333331285.0Zinc fingerC2H2-type 14
HgeneZNF423chr16:49764682chr10:70545893ENST00000561648-38662_68492.333333333333331285.0Zinc fingerC2H2-type 15
HgeneZNF423chr16:49764682chr10:70545893ENST00000561648-38692_71592.333333333333331285.0Zinc fingerC2H2-type 16
HgeneZNF423chr16:49764682chr10:70545893ENST00000561648-38720_74392.333333333333331285.0Zinc fingerC2H2-type 17
HgeneZNF423chr16:49764682chr10:70545893ENST00000561648-38750_77392.333333333333331285.0Zinc fingerC2H2-type 18
HgeneZNF423chr16:49764682chr10:70545893ENST00000561648-38781_80392.333333333333331285.0Zinc fingerC2H2-type 19
HgeneZNF423chr16:49764682chr10:70545893ENST00000561648-38807_83092.333333333333331285.0Zinc fingerC2H2-type 20
HgeneZNF423chr16:49764682chr10:70545893ENST00000561648-38886_90892.333333333333331285.0Zinc fingerC2H2-type 21%3B degenerate
HgeneZNF423chr16:49764682chr10:70545893ENST00000561648-38930_95292.333333333333331285.0Zinc fingerC2H2-type 22
HgeneZNF423chr16:49764682chr10:70545893ENST00000561648-38959_98192.333333333333331285.0Zinc fingerC2H2-type 23
HgeneZNF423chr16:49764682chr10:70545893ENST00000562520-381020_104232.3333333333333361225.0Zinc fingerC2H2-type 24
HgeneZNF423chr16:49764682chr10:70545893ENST00000562520-381064_108232.3333333333333361225.0Zinc fingerC2H2-type 25%3B degenerate
HgeneZNF423chr16:49764682chr10:70545893ENST00000562520-381120_114332.3333333333333361225.0Zinc fingerC2H2-type 26
HgeneZNF423chr16:49764682chr10:70545893ENST00000562520-381168_119032.3333333333333361225.0Zinc fingerC2H2-type 27
HgeneZNF423chr16:49764682chr10:70545893ENST00000562520-381198_122032.3333333333333361225.0Zinc fingerC2H2-type 28
HgeneZNF423chr16:49764682chr10:70545893ENST00000562520-381229_125232.3333333333333361225.0Zinc fingerC2H2-type 29
HgeneZNF423chr16:49764682chr10:70545893ENST00000562520-381259_128232.3333333333333361225.0Zinc fingerC2H2-type 30
HgeneZNF423chr16:49764682chr10:70545893ENST00000562520-38138_16032.3333333333333361225.0Zinc fingerC2H2-type 2
HgeneZNF423chr16:49764682chr10:70545893ENST00000562520-38166_18832.3333333333333361225.0Zinc fingerC2H2-type 3
HgeneZNF423chr16:49764682chr10:70545893ENST00000562520-38194_21632.3333333333333361225.0Zinc fingerC2H2-type 4
HgeneZNF423chr16:49764682chr10:70545893ENST00000562520-38222_24432.3333333333333361225.0Zinc fingerC2H2-type 5
HgeneZNF423chr16:49764682chr10:70545893ENST00000562520-38263_28632.3333333333333361225.0Zinc fingerC2H2-type 6
HgeneZNF423chr16:49764682chr10:70545893ENST00000562520-38295_31832.3333333333333361225.0Zinc fingerC2H2-type 7
HgeneZNF423chr16:49764682chr10:70545893ENST00000562520-38323_34532.3333333333333361225.0Zinc fingerC2H2-type 8
HgeneZNF423chr16:49764682chr10:70545893ENST00000562520-38409_43332.3333333333333361225.0Zinc fingerC2H2-type 9%3B degenerate
HgeneZNF423chr16:49764682chr10:70545893ENST00000562520-38441_46432.3333333333333361225.0Zinc fingerC2H2-type 10
HgeneZNF423chr16:49764682chr10:70545893ENST00000562520-38480_50332.3333333333333361225.0Zinc fingerC2H2-type 11
HgeneZNF423chr16:49764682chr10:70545893ENST00000562520-38517_54032.3333333333333361225.0Zinc fingerC2H2-type 12
HgeneZNF423chr16:49764682chr10:70545893ENST00000562520-38563_58832.3333333333333361225.0Zinc fingerC2H2-type 13%3B atypical
HgeneZNF423chr16:49764682chr10:70545893ENST00000562520-38632_65432.3333333333333361225.0Zinc fingerC2H2-type 14
HgeneZNF423chr16:49764682chr10:70545893ENST00000562520-38662_68432.3333333333333361225.0Zinc fingerC2H2-type 15
HgeneZNF423chr16:49764682chr10:70545893ENST00000562520-3867_9332.3333333333333361225.0Zinc fingerC2H2-type 1%3B degenerate
HgeneZNF423chr16:49764682chr10:70545893ENST00000562520-38692_71532.3333333333333361225.0Zinc fingerC2H2-type 16
HgeneZNF423chr16:49764682chr10:70545893ENST00000562520-38720_74332.3333333333333361225.0Zinc fingerC2H2-type 17
HgeneZNF423chr16:49764682chr10:70545893ENST00000562520-38750_77332.3333333333333361225.0Zinc fingerC2H2-type 18
HgeneZNF423chr16:49764682chr10:70545893ENST00000562520-38781_80332.3333333333333361225.0Zinc fingerC2H2-type 19
HgeneZNF423chr16:49764682chr10:70545893ENST00000562520-38807_83032.3333333333333361225.0Zinc fingerC2H2-type 20
HgeneZNF423chr16:49764682chr10:70545893ENST00000562520-38886_90832.3333333333333361225.0Zinc fingerC2H2-type 21%3B degenerate
HgeneZNF423chr16:49764682chr10:70545893ENST00000562520-38930_95232.3333333333333361225.0Zinc fingerC2H2-type 22
HgeneZNF423chr16:49764682chr10:70545893ENST00000562520-38959_98132.3333333333333361225.0Zinc fingerC2H2-type 23
HgeneZNF423chr16:49764682chr10:70545893ENST00000562871-271020_104232.3333333333333361225.0Zinc fingerC2H2-type 24
HgeneZNF423chr16:49764682chr10:70545893ENST00000562871-271064_108232.3333333333333361225.0Zinc fingerC2H2-type 25%3B degenerate
HgeneZNF423chr16:49764682chr10:70545893ENST00000562871-271120_114332.3333333333333361225.0Zinc fingerC2H2-type 26
HgeneZNF423chr16:49764682chr10:70545893ENST00000562871-271168_119032.3333333333333361225.0Zinc fingerC2H2-type 27
HgeneZNF423chr16:49764682chr10:70545893ENST00000562871-271198_122032.3333333333333361225.0Zinc fingerC2H2-type 28
HgeneZNF423chr16:49764682chr10:70545893ENST00000562871-271229_125232.3333333333333361225.0Zinc fingerC2H2-type 29
HgeneZNF423chr16:49764682chr10:70545893ENST00000562871-271259_128232.3333333333333361225.0Zinc fingerC2H2-type 30
HgeneZNF423chr16:49764682chr10:70545893ENST00000562871-27138_16032.3333333333333361225.0Zinc fingerC2H2-type 2
HgeneZNF423chr16:49764682chr10:70545893ENST00000562871-27166_18832.3333333333333361225.0Zinc fingerC2H2-type 3
HgeneZNF423chr16:49764682chr10:70545893ENST00000562871-27194_21632.3333333333333361225.0Zinc fingerC2H2-type 4
HgeneZNF423chr16:49764682chr10:70545893ENST00000562871-27222_24432.3333333333333361225.0Zinc fingerC2H2-type 5
HgeneZNF423chr16:49764682chr10:70545893ENST00000562871-27263_28632.3333333333333361225.0Zinc fingerC2H2-type 6
HgeneZNF423chr16:49764682chr10:70545893ENST00000562871-27295_31832.3333333333333361225.0Zinc fingerC2H2-type 7
HgeneZNF423chr16:49764682chr10:70545893ENST00000562871-27323_34532.3333333333333361225.0Zinc fingerC2H2-type 8
HgeneZNF423chr16:49764682chr10:70545893ENST00000562871-27409_43332.3333333333333361225.0Zinc fingerC2H2-type 9%3B degenerate
HgeneZNF423chr16:49764682chr10:70545893ENST00000562871-27441_46432.3333333333333361225.0Zinc fingerC2H2-type 10
HgeneZNF423chr16:49764682chr10:70545893ENST00000562871-27480_50332.3333333333333361225.0Zinc fingerC2H2-type 11
HgeneZNF423chr16:49764682chr10:70545893ENST00000562871-27517_54032.3333333333333361225.0Zinc fingerC2H2-type 12
HgeneZNF423chr16:49764682chr10:70545893ENST00000562871-27563_58832.3333333333333361225.0Zinc fingerC2H2-type 13%3B atypical
HgeneZNF423chr16:49764682chr10:70545893ENST00000562871-27632_65432.3333333333333361225.0Zinc fingerC2H2-type 14
HgeneZNF423chr16:49764682chr10:70545893ENST00000562871-27662_68432.3333333333333361225.0Zinc fingerC2H2-type 15
HgeneZNF423chr16:49764682chr10:70545893ENST00000562871-2767_9332.3333333333333361225.0Zinc fingerC2H2-type 1%3B degenerate
HgeneZNF423chr16:49764682chr10:70545893ENST00000562871-27692_71532.3333333333333361225.0Zinc fingerC2H2-type 16
HgeneZNF423chr16:49764682chr10:70545893ENST00000562871-27720_74332.3333333333333361225.0Zinc fingerC2H2-type 17
HgeneZNF423chr16:49764682chr10:70545893ENST00000562871-27750_77332.3333333333333361225.0Zinc fingerC2H2-type 18
HgeneZNF423chr16:49764682chr10:70545893ENST00000562871-27781_80332.3333333333333361225.0Zinc fingerC2H2-type 19
HgeneZNF423chr16:49764682chr10:70545893ENST00000562871-27807_83032.3333333333333361225.0Zinc fingerC2H2-type 20
HgeneZNF423chr16:49764682chr10:70545893ENST00000562871-27886_90832.3333333333333361225.0Zinc fingerC2H2-type 21%3B degenerate
HgeneZNF423chr16:49764682chr10:70545893ENST00000562871-27930_95232.3333333333333361225.0Zinc fingerC2H2-type 22
HgeneZNF423chr16:49764682chr10:70545893ENST00000562871-27959_98132.3333333333333361225.0Zinc fingerC2H2-type 23
HgeneZNF423chr16:49764682chr10:70545893ENST00000563137-381020_104232.3333333333333361225.0Zinc fingerC2H2-type 24
HgeneZNF423chr16:49764682chr10:70545893ENST00000563137-381064_108232.3333333333333361225.0Zinc fingerC2H2-type 25%3B degenerate
HgeneZNF423chr16:49764682chr10:70545893ENST00000563137-381120_114332.3333333333333361225.0Zinc fingerC2H2-type 26
HgeneZNF423chr16:49764682chr10:70545893ENST00000563137-381168_119032.3333333333333361225.0Zinc fingerC2H2-type 27
HgeneZNF423chr16:49764682chr10:70545893ENST00000563137-381198_122032.3333333333333361225.0Zinc fingerC2H2-type 28
HgeneZNF423chr16:49764682chr10:70545893ENST00000563137-381229_125232.3333333333333361225.0Zinc fingerC2H2-type 29
HgeneZNF423chr16:49764682chr10:70545893ENST00000563137-381259_128232.3333333333333361225.0Zinc fingerC2H2-type 30
HgeneZNF423chr16:49764682chr10:70545893ENST00000563137-38138_16032.3333333333333361225.0Zinc fingerC2H2-type 2
HgeneZNF423chr16:49764682chr10:70545893ENST00000563137-38166_18832.3333333333333361225.0Zinc fingerC2H2-type 3
HgeneZNF423chr16:49764682chr10:70545893ENST00000563137-38194_21632.3333333333333361225.0Zinc fingerC2H2-type 4
HgeneZNF423chr16:49764682chr10:70545893ENST00000563137-38222_24432.3333333333333361225.0Zinc fingerC2H2-type 5
HgeneZNF423chr16:49764682chr10:70545893ENST00000563137-38263_28632.3333333333333361225.0Zinc fingerC2H2-type 6
HgeneZNF423chr16:49764682chr10:70545893ENST00000563137-38295_31832.3333333333333361225.0Zinc fingerC2H2-type 7
HgeneZNF423chr16:49764682chr10:70545893ENST00000563137-38323_34532.3333333333333361225.0Zinc fingerC2H2-type 8
HgeneZNF423chr16:49764682chr10:70545893ENST00000563137-38409_43332.3333333333333361225.0Zinc fingerC2H2-type 9%3B degenerate
HgeneZNF423chr16:49764682chr10:70545893ENST00000563137-38441_46432.3333333333333361225.0Zinc fingerC2H2-type 10
HgeneZNF423chr16:49764682chr10:70545893ENST00000563137-38480_50332.3333333333333361225.0Zinc fingerC2H2-type 11
HgeneZNF423chr16:49764682chr10:70545893ENST00000563137-38517_54032.3333333333333361225.0Zinc fingerC2H2-type 12
HgeneZNF423chr16:49764682chr10:70545893ENST00000563137-38563_58832.3333333333333361225.0Zinc fingerC2H2-type 13%3B atypical
HgeneZNF423chr16:49764682chr10:70545893ENST00000563137-38632_65432.3333333333333361225.0Zinc fingerC2H2-type 14
HgeneZNF423chr16:49764682chr10:70545893ENST00000563137-38662_68432.3333333333333361225.0Zinc fingerC2H2-type 15
HgeneZNF423chr16:49764682chr10:70545893ENST00000563137-3867_9332.3333333333333361225.0Zinc fingerC2H2-type 1%3B degenerate
HgeneZNF423chr16:49764682chr10:70545893ENST00000563137-38692_71532.3333333333333361225.0Zinc fingerC2H2-type 16
HgeneZNF423chr16:49764682chr10:70545893ENST00000563137-38720_74332.3333333333333361225.0Zinc fingerC2H2-type 17
HgeneZNF423chr16:49764682chr10:70545893ENST00000563137-38750_77332.3333333333333361225.0Zinc fingerC2H2-type 18
HgeneZNF423chr16:49764682chr10:70545893ENST00000563137-38781_80332.3333333333333361225.0Zinc fingerC2H2-type 19
HgeneZNF423chr16:49764682chr10:70545893ENST00000563137-38807_83032.3333333333333361225.0Zinc fingerC2H2-type 20
HgeneZNF423chr16:49764682chr10:70545893ENST00000563137-38886_90832.3333333333333361225.0Zinc fingerC2H2-type 21%3B degenerate
HgeneZNF423chr16:49764682chr10:70545893ENST00000563137-38930_95232.3333333333333361225.0Zinc fingerC2H2-type 22
HgeneZNF423chr16:49764682chr10:70545893ENST00000563137-38959_98132.3333333333333361225.0Zinc fingerC2H2-type 23
TgeneCCAR1chr16:49764681chr10:70545892ENST000002658721825594_618883.33333333333341151.0Coiled coilOntology_term=ECO:0000255
TgeneCCAR1chr16:49764681chr10:70545892ENST000005350161724594_618868.33333333333341136.0Coiled coilOntology_term=ECO:0000255
TgeneCCAR1chr16:49764681chr10:70545892ENST000005437191724594_618868.33333333333341136.0Coiled coilOntology_term=ECO:0000255
TgeneCCAR1chr16:49764682chr10:70545893ENST000002658721825594_618883.33333333333341151.0Coiled coilOntology_term=ECO:0000255
TgeneCCAR1chr16:49764682chr10:70545893ENST000005350161724594_618868.33333333333341136.0Coiled coilOntology_term=ECO:0000255
TgeneCCAR1chr16:49764682chr10:70545893ENST000005437191724594_618868.33333333333341136.0Coiled coilOntology_term=ECO:0000255
TgeneCCAR1chr16:49764681chr10:70545892ENST000002658721825293_361883.33333333333341151.0Compositional biasNote=Arg-rich
TgeneCCAR1chr16:49764681chr10:70545892ENST000002658721825673_889883.33333333333341151.0Compositional biasNote=Glu-rich
TgeneCCAR1chr16:49764681chr10:70545892ENST00000265872182573_79883.33333333333341151.0Compositional biasNote=Poly-Ala
TgeneCCAR1chr16:49764681chr10:70545892ENST000005350161724293_361868.33333333333341136.0Compositional biasNote=Arg-rich
TgeneCCAR1chr16:49764681chr10:70545892ENST000005350161724673_889868.33333333333341136.0Compositional biasNote=Glu-rich
TgeneCCAR1chr16:49764681chr10:70545892ENST00000535016172473_79868.33333333333341136.0Compositional biasNote=Poly-Ala
TgeneCCAR1chr16:49764681chr10:70545892ENST000005437191724293_361868.33333333333341136.0Compositional biasNote=Arg-rich
TgeneCCAR1chr16:49764681chr10:70545892ENST000005437191724673_889868.33333333333341136.0Compositional biasNote=Glu-rich
TgeneCCAR1chr16:49764681chr10:70545892ENST00000543719172473_79868.33333333333341136.0Compositional biasNote=Poly-Ala
TgeneCCAR1chr16:49764682chr10:70545893ENST000002658721825293_361883.33333333333341151.0Compositional biasNote=Arg-rich
TgeneCCAR1chr16:49764682chr10:70545893ENST000002658721825673_889883.33333333333341151.0Compositional biasNote=Glu-rich
TgeneCCAR1chr16:49764682chr10:70545893ENST00000265872182573_79883.33333333333341151.0Compositional biasNote=Poly-Ala
TgeneCCAR1chr16:49764682chr10:70545893ENST000005350161724293_361868.33333333333341136.0Compositional biasNote=Arg-rich
TgeneCCAR1chr16:49764682chr10:70545893ENST000005350161724673_889868.33333333333341136.0Compositional biasNote=Glu-rich
TgeneCCAR1chr16:49764682chr10:70545893ENST00000535016172473_79868.33333333333341136.0Compositional biasNote=Poly-Ala
TgeneCCAR1chr16:49764682chr10:70545893ENST000005437191724293_361868.33333333333341136.0Compositional biasNote=Arg-rich
TgeneCCAR1chr16:49764682chr10:70545893ENST000005437191724673_889868.33333333333341136.0Compositional biasNote=Glu-rich
TgeneCCAR1chr16:49764682chr10:70545893ENST00000543719172473_79868.33333333333341136.0Compositional biasNote=Poly-Ala
TgeneCCAR1chr16:49764681chr10:70545892ENST000002658721825636_670883.33333333333341151.0DomainSAP
TgeneCCAR1chr16:49764681chr10:70545892ENST000005350161724636_670868.33333333333341136.0DomainSAP
TgeneCCAR1chr16:49764681chr10:70545892ENST000005437191724636_670868.33333333333341136.0DomainSAP
TgeneCCAR1chr16:49764682chr10:70545893ENST000002658721825636_670883.33333333333341151.0DomainSAP
TgeneCCAR1chr16:49764682chr10:70545893ENST000005350161724636_670868.33333333333341136.0DomainSAP
TgeneCCAR1chr16:49764682chr10:70545893ENST000005437191724636_670868.33333333333341136.0DomainSAP


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file >>>703_ZNF423_49764682_CCAR1_70545893_ranked_0.pdbZNF4234976468149764682ENST00000543719CCAR1chr1070545893+
MHKKRVEEGEASDFSLAWDSSVTAAGGLEGEPECDQKTSRALEDRNSVTSQEERNEDDEDMEDESIYTCDHCQQDFESLADLTDHRAHRC
PGDRDEEEMTKRDDKRDINRYCKERPSKDKEKEKTQMITINRDLLMAFVYFDQSHCGYLLEKDLEEILYTLGLHLSRAQVKKLLNKVVLR
ESCFYRKLTDTSKDEENHEESESLQEDMLGNRLLLPTPTVKQESKDVEENVGLIVYNGAMVDVGSLLQKLEKSEKVRAEVEQKLQLLEEK
359


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
ZNF423_pLDDT.png
all structure
all structure
CCAR1_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
all structure


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
ZNF423
CCAR1


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneCCAR1chr16:49764681chr10:70545892ENST0000026587218251_249883.33333333333341151.0AR
TgeneCCAR1chr16:49764681chr10:70545892ENST0000053501617241_249868.33333333333341136.0AR
TgeneCCAR1chr16:49764681chr10:70545892ENST0000054371917241_249868.33333333333341136.0AR
TgeneCCAR1chr16:49764682chr10:70545893ENST0000026587218251_249883.33333333333341151.0AR
TgeneCCAR1chr16:49764682chr10:70545893ENST0000053501617241_249868.33333333333341136.0AR
TgeneCCAR1chr16:49764682chr10:70545893ENST0000054371917241_249868.33333333333341136.0AR
TgeneCCAR1chr16:49764681chr10:70545892ENST000002658721825643_1150883.33333333333341151.0GATA1
TgeneCCAR1chr16:49764681chr10:70545892ENST000005350161724643_1150868.33333333333341136.0GATA1
TgeneCCAR1chr16:49764681chr10:70545892ENST000005437191724643_1150868.33333333333341136.0GATA1
TgeneCCAR1chr16:49764682chr10:70545893ENST000002658721825643_1150883.33333333333341151.0GATA1
TgeneCCAR1chr16:49764682chr10:70545893ENST000005350161724643_1150868.33333333333341136.0GATA1
TgeneCCAR1chr16:49764682chr10:70545893ENST000005437191724643_1150868.33333333333341136.0GATA1
TgeneCCAR1chr16:49764681chr10:70545892ENST000002658721825203_660883.33333333333341151.0GATA2
TgeneCCAR1chr16:49764681chr10:70545892ENST000005350161724203_660868.33333333333341136.0GATA2
TgeneCCAR1chr16:49764681chr10:70545892ENST000005437191724203_660868.33333333333341136.0GATA2
TgeneCCAR1chr16:49764682chr10:70545893ENST000002658721825203_660883.33333333333341151.0GATA2
TgeneCCAR1chr16:49764682chr10:70545893ENST000005350161724203_660868.33333333333341136.0GATA2
TgeneCCAR1chr16:49764682chr10:70545893ENST000005437191724203_660868.33333333333341136.0GATA2


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Related Drugs to ZNF423-CCAR1


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to ZNF423-CCAR1


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource