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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:ZNF429-RBMS3

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: ZNF429-RBMS3
	FusionPDB ID: 102075
	FusionGDB2.0 ID: 102075
		Hgene	Tgene
	Gene symbol	ZNF429	RBMS3
	Gene ID	353088	27303
	Gene name	zinc finger protein 429	RNA binding motif single stranded interacting protein 3
	Synonyms	-	-
	Cytomap	19p12	3p24.1
	Type of gene	protein-coding	protein-coding
	Description	zinc finger protein 429	RNA-binding motif, single-stranded-interacting protein 3RNA binding motif, single stranded interacting proteinRNA-binding protein
	Modification date	20200313	20200313
	UniProtAcc	.	.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000358491, ENST00000597078, ENST00000594022,	ENST00000473799, ENST00000273139, ENST00000383766, ENST00000383767, ENST00000396583, ENST00000434693, ENST00000445033, ENST00000452462, ENST00000456853,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	20 X 10 X 4=800	10 X 11 X 5=550
	# samples	20	11
	** MAII score	log2(20/800*10)=-2 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(11/550*10)=-2.32192809488736 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: ZNF429 [Title/Abstract] AND RBMS3 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	ZNF429(21688576)-RBMS3(29476233), # samples:1
Anticipated loss of major functional domain due to fusion event.	ZNF429-RBMS3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ZNF429-RBMS3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ZNF429-RBMS3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. ZNF429-RBMS3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across ZNF429 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across RBMS3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	ESCA	TCGA-2H-A9GO	ZNF429	chr19	21688576	+	RBMS3	chr3	29476233	+

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000358491	ZNF429	chr19	21688576	+	ENST00000434693	RBMS3	chr3	29476233	+	7976	211	208	1446	412
ENST00000358491	ZNF429	chr19	21688576	+	ENST00000396583	RBMS3	chr3	29476233	+	7974	211	208	1440	410
ENST00000358491	ZNF429	chr19	21688576	+	ENST00000383767	RBMS3	chr3	29476233	+	1664	211	208	1449	413
ENST00000358491	ZNF429	chr19	21688576	+	ENST00000445033	RBMS3	chr3	29476233	+	945	211	208	930	240
ENST00000358491	ZNF429	chr19	21688576	+	ENST00000273139	RBMS3	chr3	29476233	+	1504	211	208	1398	396
ENST00000358491	ZNF429	chr19	21688576	+	ENST00000383766	RBMS3	chr3	29476233	+	2663	211	208	1395	395
ENST00000358491	ZNF429	chr19	21688576	+	ENST00000452462	RBMS3	chr3	29476233	+	1553	211	208	1401	397
ENST00000358491	ZNF429	chr19	21688576	+	ENST00000456853	RBMS3	chr3	29476233	+	1464	211	208	1437	409
ENST00000597078	ZNF429	chr19	21688576	+	ENST00000434693	RBMS3	chr3	29476233	+	7936	171	168	1406	412
ENST00000597078	ZNF429	chr19	21688576	+	ENST00000396583	RBMS3	chr3	29476233	+	7934	171	168	1400	410
ENST00000597078	ZNF429	chr19	21688576	+	ENST00000383767	RBMS3	chr3	29476233	+	1624	171	168	1409	413
ENST00000597078	ZNF429	chr19	21688576	+	ENST00000445033	RBMS3	chr3	29476233	+	905	171	168	890	240
ENST00000597078	ZNF429	chr19	21688576	+	ENST00000273139	RBMS3	chr3	29476233	+	1464	171	168	1358	396
ENST00000597078	ZNF429	chr19	21688576	+	ENST00000383766	RBMS3	chr3	29476233	+	2623	171	168	1355	395
ENST00000597078	ZNF429	chr19	21688576	+	ENST00000452462	RBMS3	chr3	29476233	+	1513	171	168	1361	397
ENST00000597078	ZNF429	chr19	21688576	+	ENST00000456853	RBMS3	chr3	29476233	+	1424	171	168	1397	409

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000358491	ENST00000434693	ZNF429	chr19	21688576	+	RBMS3	chr3	29476233	+	0.000367793	0.99963224
ENST00000358491	ENST00000396583	ZNF429	chr19	21688576	+	RBMS3	chr3	29476233	+	0.0003081	0.99969196
ENST00000358491	ENST00000383767	ZNF429	chr19	21688576	+	RBMS3	chr3	29476233	+	0.004300572	0.9956994
ENST00000358491	ENST00000445033	ZNF429	chr19	21688576	+	RBMS3	chr3	29476233	+	0.016311787	0.98368824
ENST00000358491	ENST00000273139	ZNF429	chr19	21688576	+	RBMS3	chr3	29476233	+	0.003772551	0.9962275
ENST00000358491	ENST00000383766	ZNF429	chr19	21688576	+	RBMS3	chr3	29476233	+	0.001015093	0.9989849
ENST00000358491	ENST00000452462	ZNF429	chr19	21688576	+	RBMS3	chr3	29476233	+	0.003530948	0.996469
ENST00000358491	ENST00000456853	ZNF429	chr19	21688576	+	RBMS3	chr3	29476233	+	0.005618196	0.99438184
ENST00000597078	ENST00000434693	ZNF429	chr19	21688576	+	RBMS3	chr3	29476233	+	0.000359166	0.9996408
ENST00000597078	ENST00000396583	ZNF429	chr19	21688576	+	RBMS3	chr3	29476233	+	0.000299378	0.99970067
ENST00000597078	ENST00000383767	ZNF429	chr19	21688576	+	RBMS3	chr3	29476233	+	0.004211873	0.99578816
ENST00000597078	ENST00000445033	ZNF429	chr19	21688576	+	RBMS3	chr3	29476233	+	0.015669672	0.98433036
ENST00000597078	ENST00000273139	ZNF429	chr19	21688576	+	RBMS3	chr3	29476233	+	0.003811304	0.9961887
ENST00000597078	ENST00000383766	ZNF429	chr19	21688576	+	RBMS3	chr3	29476233	+	0.0009268	0.99907315
ENST00000597078	ENST00000452462	ZNF429	chr19	21688576	+	RBMS3	chr3	29476233	+	0.003553249	0.9964468
ENST00000597078	ENST00000456853	ZNF429	chr19	21688576	+	RBMS3	chr3	29476233	+	0.005379726	0.9946203

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>102075_102075_1_ZNF429-RBMS3_ZNF429_chr19_21688576_ENST00000358491_RBMS3_chr3_29476233_ENST00000273139_length(amino acids)=396AA_BP=1
MQSYAPAPHPMAPPSPSTNSSSNNSSNNSSGEQLSKTNLYIRGLPPGTTDQDLIKLCQPYGKIVSTKAILDKNTNQCKGYGFVDFDSPAA
AQKAVASLKANGVQAQMAKQQEQDPTNLYISNLPISMDEQELENMLKPFGHVISTRILRDANGVSRGVGFARMESTEKCEVVIQHFNGKY
LKTPPGIPAPSEPLLCKFADGGQKKRQNQSKYTQNGRPWPREGEAGMALTYDPTAAIQNGFYSSPYSIATNRMIPQTSITPFIAASPVST
YQVQSTSWMPHPPYVMQPTGAVITPTMDHPMSMQPANMMGPLTQQMNHLSLGTTGTYMTAAAPMQGTYIPQYTPVPPTAVSIEGVVADTS

--------------------------------------------------------------

>102075_102075_2_ZNF429-RBMS3_ZNF429_chr19_21688576_ENST00000358491_RBMS3_chr3_29476233_ENST00000383766_length(amino acids)=395AA_BP=1
MSYAPAPHPMAPPSPSTNSSSNNSSNNSSGEQLSKTNLYIRGLPPGTTDQDLIKLCQPYGKIVSTKAILDKNTNQCKGYGFVDFDSPAAA
QKAVASLKANGVQAQMAKQQEQDPTNLYISNLPISMDEQELENMLKPFGHVISTRILRDANGVSRGVGFARMESTEKCEVVIQHFNGKYL
KTPPGIPAPSEPLLCKFADGGQKKRQNQSKYTQNGRPWPREGEAGMALTYDPTAAIQNGFYSSPYSIATNRMIPQTSITPFIAASPVSTY
QGAVITPTMDHPMSMQPANMMGPLTQQMNHLSLGTTGTIQSQDRIMILHQLLCQYMTAAAPMQGTYIPQYTPVPPTAVSIEGVVADTSPQ

--------------------------------------------------------------

>102075_102075_3_ZNF429-RBMS3_ZNF429_chr19_21688576_ENST00000358491_RBMS3_chr3_29476233_ENST00000383767_length(amino acids)=413AA_BP=1
MQSYAPAPHPMAPPSPSTNSSSNNSSNNSSGEQLSKTNLYIRGLPPGTTDQDLIKLCQPYGKIVSTKAILDKNTNQCKGYGFVDFDSPAA
AQKAVASLKANGVQAQMAKQQEQDPTNLYISNLPISMDEQELENMLKPFGHVISTRILRDANGVSRGVGFARMESTEKCEVVIQHFNGKY
LKTPPGIPAPSEPLLCKFADGGQKKRQNQSKYTQNGRPWPREGEAGMALTYDPTAAIQNGFYSSPYSIATNRMIPQTSITPFIAASPVST
YQVQSTSWMPHPPYVMQPTGAVITPTMDHPMSMQPANMMGPLTQQMNHLSLGTTGTIQSQDRIMILHQLLCQYMTAAAPMQGTYIPQYTP

--------------------------------------------------------------

>102075_102075_4_ZNF429-RBMS3_ZNF429_chr19_21688576_ENST00000358491_RBMS3_chr3_29476233_ENST00000396583_length(amino acids)=410AA_BP=1
MQSYAPAPHPMAPPSPSTNSSSNNSSNNSSGEQLSKTNLYIRGLPPGTTDQDLIKLCQPYGKIVSTKAILDKNTNQCKGYGFVDFDSPAA
AQKAVASLKANGVQAQMAKQQEQDPTNLYISNLPISMDEQELENMLKPFGHVISTRILRDANGVSRGVGFARMESTEKCEVVIQHFNGKY
LKTPPGIPAPSEPLLCKFADGGQKKRQNQSKYTQNGRPWPREGEVLRGRTVPRQNREAGMALTYDPTAAIQNGFYSSPYSIATNRMIPQT
SITPFIAASPVSTYQVQSTSWMPHPPYVMQPTGAVITPTMDHPMSMQPANMMGPLTQQMNHLSLGTTGTYMTAAAPMQGTYIPQYTPVPP

--------------------------------------------------------------

>102075_102075_5_ZNF429-RBMS3_ZNF429_chr19_21688576_ENST00000358491_RBMS3_chr3_29476233_ENST00000434693_length(amino acids)=412AA_BP=1
MSYAPAPHPMAPPSPSTNSSSNNSSNNSSGEQLSKTNLYIRGLPPGTTDQDLIKLCQPYGKIVSTKAILDKNTNQCKGYGFVDFDSPAAA
QKAVASLKANGVQAQMAKQQEQDPTNLYISNLPISMDEQELENMLKPFGHVISTRILRDANGVSRGVGFARMESTEKCEVVIQHFNGKYL
KTPPGIPAPSEPLLCKFADGGQKKRQNQSKYTQNGRPWPREGEAGMALTYDPTAAIQNGFYSSPYSIATNRMIPQTSITPFIAASPVSTY
QVQSTSWMPHPPYVMQPTGAVITPTMDHPMSMQPANMMGPLTQQMNHLSLGTTGTIQSQDRIMILHQLLCQYMTAAAPMQGTYIPQYTPV

--------------------------------------------------------------

>102075_102075_6_ZNF429-RBMS3_ZNF429_chr19_21688576_ENST00000358491_RBMS3_chr3_29476233_ENST00000445033_length(amino acids)=240AA_BP=1
MQSYAPAPHPMAPPSPSTNSSSNNSSNNSSGEQLSKTNLYIRGLPPGTTDQDLIKLCQPYGKIVSTKAILDKNTNQCKGYGFVDFDSPAA
AQKAVASLKANGVQAQMAKQQEQDPTNLYISNLPISMDEQELENMLKPFGHVISTRILRDANGVSRGVGFARMESTEKCEVVIQHFNGKY

--------------------------------------------------------------

>102075_102075_7_ZNF429-RBMS3_ZNF429_chr19_21688576_ENST00000358491_RBMS3_chr3_29476233_ENST00000452462_length(amino acids)=397AA_BP=1
MQSYAPAPHPMAPPSPSTNSSSNNSSNNSSGEQLSKTNLYIRGLPPGTTDQDLIKLCQPYGKIVSTKAILDKNTNQCKGYGFVDFDSPAA
AQKAVASLKANGVQAQMAKQQEQDPTNLYISNLPISMDEQELENMLKPFGHVISTRILRDANGVSRGVGFARMESTEKCEVVIQHFNGKY
LKTPPGIPAPSEPLLCKFADGGQKKRQNQSKYTQNGRPWPREGEAGMALTYDPTAAIQNGFYSSPYSIATNRMIPQTSITPFIAASPVST
YQVQSTSWMPHPPYVMQPTGAVITPTMDHPMSMQPANMMGPLTQQMNHLSLGTTGTYMTAAAPMQGTYIPQYTPVPPTAVSIEGVVADTS

--------------------------------------------------------------

>102075_102075_8_ZNF429-RBMS3_ZNF429_chr19_21688576_ENST00000358491_RBMS3_chr3_29476233_ENST00000456853_length(amino acids)=409AA_BP=1
MQSYAPAPHPMAPPSPSTNSSSNNSSNNSSGEQLSKTNLYIRGLPPGTTDQDLIKLCQPYGKIVSTKAILDKNTNQCKGYGFVDFDSPAA
AQKAVASLKANGVQAQMAKQQEQDPTNLYISNLPISMDEQELENMLKPFGHVISTRILRDANGVSRGVGFARMESTEKCEVVIQHFNGKY
LKTPPGIPAPSEPLLCKFADGGQKKRQNQSKYTQNGRPWPREGEVLRGRTVPRQNREAGMALTYDPTAAIQNGFYSSPYSIATNRMIPQT
SITPFIAASPVSTYQVQSTSWMPHPPYVMQPTGAVITPTMDHPMSMQPANMMGPLTQQMNHLSLGTTGTYMTAAAPMQGTYIPQYTPVPP

--------------------------------------------------------------

>102075_102075_9_ZNF429-RBMS3_ZNF429_chr19_21688576_ENST00000597078_RBMS3_chr3_29476233_ENST00000273139_length(amino acids)=396AA_BP=1
MQSYAPAPHPMAPPSPSTNSSSNNSSNNSSGEQLSKTNLYIRGLPPGTTDQDLIKLCQPYGKIVSTKAILDKNTNQCKGYGFVDFDSPAA
AQKAVASLKANGVQAQMAKQQEQDPTNLYISNLPISMDEQELENMLKPFGHVISTRILRDANGVSRGVGFARMESTEKCEVVIQHFNGKY
LKTPPGIPAPSEPLLCKFADGGQKKRQNQSKYTQNGRPWPREGEAGMALTYDPTAAIQNGFYSSPYSIATNRMIPQTSITPFIAASPVST
YQVQSTSWMPHPPYVMQPTGAVITPTMDHPMSMQPANMMGPLTQQMNHLSLGTTGTYMTAAAPMQGTYIPQYTPVPPTAVSIEGVVADTS

--------------------------------------------------------------

>102075_102075_10_ZNF429-RBMS3_ZNF429_chr19_21688576_ENST00000597078_RBMS3_chr3_29476233_ENST00000383766_length(amino acids)=395AA_BP=1
MSYAPAPHPMAPPSPSTNSSSNNSSNNSSGEQLSKTNLYIRGLPPGTTDQDLIKLCQPYGKIVSTKAILDKNTNQCKGYGFVDFDSPAAA
QKAVASLKANGVQAQMAKQQEQDPTNLYISNLPISMDEQELENMLKPFGHVISTRILRDANGVSRGVGFARMESTEKCEVVIQHFNGKYL
KTPPGIPAPSEPLLCKFADGGQKKRQNQSKYTQNGRPWPREGEAGMALTYDPTAAIQNGFYSSPYSIATNRMIPQTSITPFIAASPVSTY
QGAVITPTMDHPMSMQPANMMGPLTQQMNHLSLGTTGTIQSQDRIMILHQLLCQYMTAAAPMQGTYIPQYTPVPPTAVSIEGVVADTSPQ

--------------------------------------------------------------

>102075_102075_11_ZNF429-RBMS3_ZNF429_chr19_21688576_ENST00000597078_RBMS3_chr3_29476233_ENST00000383767_length(amino acids)=413AA_BP=1
MQSYAPAPHPMAPPSPSTNSSSNNSSNNSSGEQLSKTNLYIRGLPPGTTDQDLIKLCQPYGKIVSTKAILDKNTNQCKGYGFVDFDSPAA
AQKAVASLKANGVQAQMAKQQEQDPTNLYISNLPISMDEQELENMLKPFGHVISTRILRDANGVSRGVGFARMESTEKCEVVIQHFNGKY
LKTPPGIPAPSEPLLCKFADGGQKKRQNQSKYTQNGRPWPREGEAGMALTYDPTAAIQNGFYSSPYSIATNRMIPQTSITPFIAASPVST
YQVQSTSWMPHPPYVMQPTGAVITPTMDHPMSMQPANMMGPLTQQMNHLSLGTTGTIQSQDRIMILHQLLCQYMTAAAPMQGTYIPQYTP

--------------------------------------------------------------

>102075_102075_12_ZNF429-RBMS3_ZNF429_chr19_21688576_ENST00000597078_RBMS3_chr3_29476233_ENST00000396583_length(amino acids)=410AA_BP=1
MQSYAPAPHPMAPPSPSTNSSSNNSSNNSSGEQLSKTNLYIRGLPPGTTDQDLIKLCQPYGKIVSTKAILDKNTNQCKGYGFVDFDSPAA
AQKAVASLKANGVQAQMAKQQEQDPTNLYISNLPISMDEQELENMLKPFGHVISTRILRDANGVSRGVGFARMESTEKCEVVIQHFNGKY
LKTPPGIPAPSEPLLCKFADGGQKKRQNQSKYTQNGRPWPREGEVLRGRTVPRQNREAGMALTYDPTAAIQNGFYSSPYSIATNRMIPQT
SITPFIAASPVSTYQVQSTSWMPHPPYVMQPTGAVITPTMDHPMSMQPANMMGPLTQQMNHLSLGTTGTYMTAAAPMQGTYIPQYTPVPP

--------------------------------------------------------------

>102075_102075_13_ZNF429-RBMS3_ZNF429_chr19_21688576_ENST00000597078_RBMS3_chr3_29476233_ENST00000434693_length(amino acids)=412AA_BP=1
MSYAPAPHPMAPPSPSTNSSSNNSSNNSSGEQLSKTNLYIRGLPPGTTDQDLIKLCQPYGKIVSTKAILDKNTNQCKGYGFVDFDSPAAA
QKAVASLKANGVQAQMAKQQEQDPTNLYISNLPISMDEQELENMLKPFGHVISTRILRDANGVSRGVGFARMESTEKCEVVIQHFNGKYL
KTPPGIPAPSEPLLCKFADGGQKKRQNQSKYTQNGRPWPREGEAGMALTYDPTAAIQNGFYSSPYSIATNRMIPQTSITPFIAASPVSTY
QVQSTSWMPHPPYVMQPTGAVITPTMDHPMSMQPANMMGPLTQQMNHLSLGTTGTIQSQDRIMILHQLLCQYMTAAAPMQGTYIPQYTPV

--------------------------------------------------------------

>102075_102075_14_ZNF429-RBMS3_ZNF429_chr19_21688576_ENST00000597078_RBMS3_chr3_29476233_ENST00000445033_length(amino acids)=240AA_BP=1
MQSYAPAPHPMAPPSPSTNSSSNNSSNNSSGEQLSKTNLYIRGLPPGTTDQDLIKLCQPYGKIVSTKAILDKNTNQCKGYGFVDFDSPAA
AQKAVASLKANGVQAQMAKQQEQDPTNLYISNLPISMDEQELENMLKPFGHVISTRILRDANGVSRGVGFARMESTEKCEVVIQHFNGKY

--------------------------------------------------------------

>102075_102075_15_ZNF429-RBMS3_ZNF429_chr19_21688576_ENST00000597078_RBMS3_chr3_29476233_ENST00000452462_length(amino acids)=397AA_BP=1
MQSYAPAPHPMAPPSPSTNSSSNNSSNNSSGEQLSKTNLYIRGLPPGTTDQDLIKLCQPYGKIVSTKAILDKNTNQCKGYGFVDFDSPAA
AQKAVASLKANGVQAQMAKQQEQDPTNLYISNLPISMDEQELENMLKPFGHVISTRILRDANGVSRGVGFARMESTEKCEVVIQHFNGKY
LKTPPGIPAPSEPLLCKFADGGQKKRQNQSKYTQNGRPWPREGEAGMALTYDPTAAIQNGFYSSPYSIATNRMIPQTSITPFIAASPVST
YQVQSTSWMPHPPYVMQPTGAVITPTMDHPMSMQPANMMGPLTQQMNHLSLGTTGTYMTAAAPMQGTYIPQYTPVPPTAVSIEGVVADTS

--------------------------------------------------------------

>102075_102075_16_ZNF429-RBMS3_ZNF429_chr19_21688576_ENST00000597078_RBMS3_chr3_29476233_ENST00000456853_length(amino acids)=409AA_BP=1
MQSYAPAPHPMAPPSPSTNSSSNNSSNNSSGEQLSKTNLYIRGLPPGTTDQDLIKLCQPYGKIVSTKAILDKNTNQCKGYGFVDFDSPAA
AQKAVASLKANGVQAQMAKQQEQDPTNLYISNLPISMDEQELENMLKPFGHVISTRILRDANGVSRGVGFARMESTEKCEVVIQHFNGKY
LKTPPGIPAPSEPLLCKFADGGQKKRQNQSKYTQNGRPWPREGEVLRGRTVPRQNREAGMALTYDPTAAIQNGFYSSPYSIATNRMIPQT
SITPFIAASPVSTYQVQSTSWMPHPPYVMQPTGAVITPTMDHPMSMQPANMMGPLTQQMNHLSLGTTGTYMTAAAPMQGTYIPQYTPVPP

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:21688576/chr3:29476233)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

RBMS3

chr19:21688576

chr3:29476233

ENST00000273139

140_225

25.0

421.0

Domain

RRM 2

Tgene

RBMS3

chr19:21688576

chr3:29476233

ENST00000273139

61_134

25.0

421.0

Domain

RRM 1

Tgene

RBMS3

chr19:21688576

chr3:29476233

ENST00000383766

140_225

25.0

420.0

Domain

RRM 2

Tgene

RBMS3

chr19:21688576

chr3:29476233

ENST00000383766

61_134

25.0

420.0

Domain

RRM 1

Tgene

RBMS3

chr19:21688576

chr3:29476233

ENST00000383767

140_225

25.0

438.0

Domain

RRM 2

Tgene

RBMS3

chr19:21688576

chr3:29476233

ENST00000383767

61_134

25.0

438.0

Domain

RRM 1

Tgene

RBMS3

chr19:21688576

chr3:29476233

ENST00000452462

140_225

25.0

422.0

Domain

RRM 2

Tgene

RBMS3

chr19:21688576

chr3:29476233

ENST00000452462

61_134

25.0

422.0

Domain

RRM 1

Tgene

RBMS3

chr19:21688576

chr3:29476233

ENST00000456853

140_225

25.0

434.0

Domain

RRM 2

Tgene

RBMS3

chr19:21688576

chr3:29476233

ENST00000456853

61_134

25.0

434.0

Domain

RRM 1

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ZNF429

chr19:21688576

chr3:29476233

ENST00000358491

4_75

1.0

675.0

Domain

KRAB

Hgene

ZNF429

chr19:21688576

chr3:29476233

ENST00000358491

145_167

1.0

675.0

Zinc finger

C2H2-type 1%3B degenerate

Hgene

ZNF429

chr19:21688576

chr3:29476233

ENST00000358491

173_195

1.0

675.0

Zinc finger

C2H2-type 2

Hgene

ZNF429

chr19:21688576

chr3:29476233

ENST00000358491

201_223

1.0

675.0

Zinc finger

C2H2-type 3%3B degenerate

Hgene

ZNF429

chr19:21688576

chr3:29476233

ENST00000358491

229_251

1.0

675.0

Zinc finger

C2H2-type 4

Hgene

ZNF429

chr19:21688576

chr3:29476233

ENST00000358491

257_279

1.0

675.0

Zinc finger

C2H2-type 5

Hgene

ZNF429

chr19:21688576

chr3:29476233

ENST00000358491

285_307

1.0

675.0

Zinc finger

C2H2-type 6

Hgene

ZNF429

chr19:21688576

chr3:29476233

ENST00000358491

313_335

1.0

675.0

Zinc finger

C2H2-type 7

Hgene

ZNF429

chr19:21688576

chr3:29476233

ENST00000358491

341_363

1.0

675.0

Zinc finger

C2H2-type 8

Hgene

ZNF429

chr19:21688576

chr3:29476233

ENST00000358491

369_391

1.0

675.0

Zinc finger

C2H2-type 9

Hgene

ZNF429

chr19:21688576

chr3:29476233

ENST00000358491

397_419

1.0

675.0

Zinc finger

C2H2-type 10%3B degenerate

Hgene

ZNF429

chr19:21688576

chr3:29476233

ENST00000358491

425_447

1.0

675.0

Zinc finger

C2H2-type 11

Hgene

ZNF429

chr19:21688576

chr3:29476233

ENST00000358491

453_475

1.0

675.0

Zinc finger

C2H2-type 12

Hgene

ZNF429

chr19:21688576

chr3:29476233

ENST00000358491

481_503

1.0

675.0

Zinc finger

C2H2-type 13

Hgene

ZNF429

chr19:21688576

chr3:29476233

ENST00000358491

509_531

1.0

675.0

Zinc finger

C2H2-type 14

Hgene

ZNF429

chr19:21688576

chr3:29476233

ENST00000358491

537_559

1.0

675.0

Zinc finger

C2H2-type 15

Hgene

ZNF429

chr19:21688576

chr3:29476233

ENST00000358491

565_587

1.0

675.0

Zinc finger

C2H2-type 16

Hgene

ZNF429

chr19:21688576

chr3:29476233

ENST00000358491

593_615

1.0

675.0

Zinc finger

C2H2-type 17

Hgene

ZNF429

chr19:21688576

chr3:29476233

ENST00000358491

621_643

1.0

675.0

Zinc finger

C2H2-type 18

Top

Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
ZNF429
RBMS3

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs to ZNF429-RBMS3

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to ZNF429-RBMS3

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source